oldenlandia

Summary

Summary: A plant genus of the family RUBIACEAE. Some species are used as an ingredient in Chinese and African traditional medicines. Members contain kalata B1, a macrocyclic peptide.

Top Publications

  1. Plan M, Goransson U, Clark R, Daly N, Colgrave M, Craik D. The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides. Chembiochem. 2007;8:1001-11 pubmed
    The complete suite of cyclotides present in Oldenlandia affinis (Rubiaceae), the plant that was originally found to contain this unique family of circular proteins, has been characterised...
  2. Noiarsa P, Ruchirawat S, Otsuka H, Kanchanapoom T. Chemical constituents from Oldenlandia corymbosa L. of Thai origin. J Nat Med. 2008;62:249-50 pubmed publisher
    From the whole plants of Oldenlandia corymbosa of Thai origin, ten compounds have been isolated and elucidated as geniposide, 6 alpha-hydroxygeniposide, scandoside methyl ester (6 beta-hydroxygeniposide), asperulosidic acid, ..
  3. Colgrave M, Kotze A, Huang Y, O Grady J, Simonsen S, Craik D. Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry. 2008;47:5581-9 pubmed publisher
    ..These results demonstrate that the cyclotides show potential for use in the control of gastrointestinal nematode parasites...
  4. Mylne J, Craik D. 15N cyclotides by whole plant labeling. Biopolymers. 2008;90:575-80 pubmed publisher
    ..We have developed an approach to overcome this limitation by growing the cyclotide-bearing plant Oldenlandia affinis on nitrogen-free agar media supplemented with 15N salts and obtaining complete labeling at no detriment ..
  5. Ramamoorthy S, Mudgal G, Rajesh D, Nawaz Khan F, Vijayakumar V, Rajasekaran C. Characterisation of novel pH indicator of natural dye Oldenlandia umbellata L. Nat Prod Res. 2009;23:1210-7 pubmed publisher
    b>Oldenlandia umbellata L., commonly known as 'chay root', belongs to the family Rubiaceae and is one of the unexplored dye-yielding plants. The roots from this plant are the sources of red dye...
  6. Ganbold M, Barker J, Ma R, Jones L, Carew M. Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. J Ethnopharmacol. 2010;131:396-403 pubmed publisher
    b>Oldenlandia diffusa is a traditional Chinese herbal remedy with known cytotoxic activity in vitro and in vivo...
  7. Li N, Liu C, Mi S, Wang N, Zheng X, Li Y, et al. Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of Oldenlandia diffusa extract in rats. J Chromatogr Sci. 2012;50:885-92 pubmed publisher
    ..66 to 14.74% and 1.9 to 14.55%. No substantial endogenous interference from blank plasma was observed. The method has been successfully applied to a pharmacokinetic study of Oldenlandia diffusa extract after oral administration in rats.
  8. Gupta S, Zhang D, Yi J, Shao J. Anticancer activities of Oldenlandia diffusa. J Herb Pharmacother. 2004;4:21-33 pubmed
    To investigate the anticancer activities of a Chinese herb, Oldenlandia diffusa (Bai Hua She She Cao).
  9. Daly N, Clark R, Plan M, Craik D. Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J. 2006;393:619-26 pubmed
    ..In the present study, we have isolated a new cyclotide from Oldenlandia affinis, kalata B8, which appears to be a hybrid of the two major subfamilies (Möbius and bracelet) of ..

More Information

Publications72

  1. Gillon A, Saska I, Jennings C, Guarino R, Craik D, Anderson M. Biosynthesis of circular proteins in plants. Plant J. 2008;53:505-15 pubmed
    ..we investigate production of the prototypic cyclotide kalata B1 from the precursor Oak1 from the African plant Oldenlandia affinis. Immunoprecipitation experiments and MALDI-TOF mass spectrometry analysis showed that O...
  2. Willimott S, Barker J, Jones L, Opara E. Apoptotic effect of Oldenlandia diffusa on the leukaemic cell line HL60 and human lymphocytes. J Ethnopharmacol. 2007;114:290-9 pubmed
    b>Oldenlandia diffusa is traditionally prescribed in the treatment of a number of cancers and studies suggest that it exerts a cytotoxic action specific to cancer cells...
  3. Seydel P, Gruber C, Craik D, Dörnenburg H. Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures. Appl Microbiol Biotechnol. 2007;77:275-84 pubmed
    ..during a batch process involving plant cell cultures has been performed, using the native African medical herb, Oldenlandia affinis, as a model plant. The results demonstrated the biosynthesis of kalata B1, the main cyclotide in O...
  4. Nair S, Romanuka J, Billeter M, Skjeldal L, Emmett M, Nilsson C, et al. Structural characterization of an unusually stable cyclic peptide, kalata B2 from Oldenlandia affinis. Biochim Biophys Acta. 2006;1764:1568-76 pubmed
    Kalata peptides are isolated from an African medicinal plant, Oldenlandia affinis, an aqueous decoction of which can be ingested to accelerate uterine contraction during childbirth...
  5. Gruber C, Cemazar M, Clark R, Horibe T, Renda R, Anderson M, et al. A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins. J Biol Chem. 2007;282:20435-46 pubmed
    We have isolated a protein-disulfide isomerase (PDI) from Oldenlandia affinis (OaPDI), a coffee family (Rubiaceae) plant that accumulates knotted circular proteins called cyclotides...
  6. Mylne J, Wang C, van der Weerden N, Craik D. Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers. 2010;94:635-46 pubmed publisher
    ..Long-term growth of the Rubiaceae family plant Oldenlandia affinis under different conditions reveals a diverse cyclotide gene and peptide expression profile, including ..
  7. Kim S, Chung W, Kim S, Ko S, Um J. Antiinflammatory effect of Oldenlandia diffusa and its constituent, hentriacontane, through suppression of caspase-1 activation in mouse peritoneal macrophages. Phytother Res. 2011;25:1537-46 pubmed publisher
    b>Oldenlandia diffusa (OD) has been used as a natural drug for the treatment of cancer in Asia and specifically in Korea. However, the antiinflammatory mechanisms employed by OD have yet to be completely understood...
  8. Gu G, Barone I, Gelsomino L, Giordano C, Bonofiglio D, Statti G, et al. Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ER?/Sp1-mediated p53 activation. J Cell Physiol. 2012;227:3363-72 pubmed publisher
    ..b>Oldenlandia diffusa (OD) is a well-known medicinal plant used to prevent and treat many disorders, especially cancers...
  9. Gran L, Sletten K, Skjeldal L. Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties. Chem Biodivers. 2008;5:2014-22 pubmed publisher
    A new isolation procedure for Kalata polypeptides from the tropical plant Oldenlandia affinis DC is described...
  10. Liang Z, Jiang Z, Leung K, Peng Y, Zhao Z. Distinguishing the medicinal herb Oldenlandia diffusa from similar species of the same genus using fluorescence microscopy. Microsc Res Tech. 2006;69:277-82 pubmed
    ..According to the Chinese Pharmacopoeia, its source is the species Oldenlandia diffusa (Willd.) Roxb. Two other species of the same genus, namely O. corymbosa (L.) Lam and O. tenelliflora Bl...
  11. Kim D, Lee H, Oh Y, Kim M, Kim S, Jeong T, et al. Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation. Arch Pharm Res. 2005;28:1156-60 pubmed
    ..oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb...
  12. Bonofiglio D, Giordano C, De Amicis F, Lanzino M, Andò S. Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets. Mini Rev Med Chem. 2016;16:596-604 pubmed
    ..and Epigallocatechin Gallate, a polyphenolic compound found in green tea, or purified from medicinal plant (Oldenlandia Diffusa) and fruits (Ziziphus Jujube) highlighting their potential use in breast cancer treatment...
  13. Mikula K, Krumwiede L, Plückthun A, Iwai H. Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation. J Biomol NMR. 2018;71:225-235 pubmed publisher
    ..Here, we report an enzymatic approach using bacterially produced asparagine endopeptidase from Oldenlandia affinis for segmental isotopic labeling of a protein with repetitive sequences, a designed armadillo repeat ..
  14. Lu P, Chen M, Ji C, Li W, Wei M, Wu M. Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. Oncotarget. 2016;7:45889-45900 pubmed publisher
    Here we evaluated the anti-cancer activity of aqueous Oldenlandia diffusa (OD) extracts (ODE) in colorectal cancer (CRC) cells...
  15. Grage S, Sani M, Cheneval O, Henriques S, Schalck C, Heinzmann R, et al. Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR. Biophys J. 2017;112:630-642 pubmed publisher
    ..interactions, specifically with regard to the spatial orientation of the cyclotide kalata B1 from Oldenlandia affinis when embedded in a lipid bilayer...
  16. Chung T, Choi H, Lee J, Ha S, Kwak C, Abekura F, et al. Oldenlandia diffusa suppresses metastatic potential through inhibiting matrix metalloproteinase-9 and intercellular adhesion molecule-1 expression via p38 and ERK1/2 MAPK pathways and induces apoptosis in human breast cancer MCF-7 cells. J Ethnopharmacol. 2017;195:309-317 pubmed publisher
    b>Oldenlandia diffusa (OD) has long been known as an apoptotic inducer in breast tumors in ethnomedicine. To scientifically confirm the anti-breast cancer effects of water, methanol (MeOH) and butanol (BuOH) extracts of O...
  17. Ting C, Kuo C, Hu H, Lee Y, Tsai T. Prescription frequency and patterns of Chinese herbal medicine for liver cancer patients in Taiwan: a cross-sectional analysis of the National Health Insurance Research Database. BMC Complement Altern Med. 2017;17:118 pubmed publisher
    ..Among them, we concluded that, Oldenlandia diffusa (Chinese herbal name: Bai-Hua-She-She-Cao), Radix et Rhizoma Rhei (Da Huang) and the herbal preparation ..
  18. Conlan B, Colgrave M, Gillon A, Guarino R, Craik D, Anderson M. Insights into processing and cyclization events associated with biosynthesis of the cyclic Peptide kalata B1. J Biol Chem. 2012;287:28037-46 pubmed publisher
    ..Substitution of the P2' Leu with Ala leads to hydroxylation of the neighboring proline. Through mutational analysis this novel proline hydroxylation motif was determined to be Gly-Ala-Pro-Ser. ..
  19. Hoang Anh N, Tam K, Tuan N, Thien D, Quan T, Tam N, et al. Chemical constituents of Oldenlandia pinifolia and their antiproliferative activities. Nat Prod Res. 2017;:1-7 pubmed publisher
    This study describes the chemical constituents of Oldenlandia pinifolia (Wall. Ex G. Don) Kuntze (synonym Hedyotis pinifolia Wall. Ex G. Don) and discusses their anti-proliferative activities...
  20. Behera S, Rajasekaran C, Payas S, Fulzele D, Doss C, Siva R. In vitro flowering in Oldenlandia umbellata L. J Ayurveda Integr Med. 2018;9:99-103 pubmed publisher
    b>Oldenlandia umbellata L. (Indian madder) is an antique Ayurvedic Indian herb and a source of various anthraquinone derivatives. The red dye from its roots has been used in diverse applications since ancient times...
  21. Nworu C, Ejikeme T, Ezike A, Ndu O, Akunne T, Onyeto C, et al. Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) D.C. (Rubiaceae). Afr Health Sci. 2017;17:827-843 pubmed publisher
    i>Oldenlandia affinis, commonly called 'kalata-kalata', a versatile plant used locally to treat malaria fever in some parts of sub-Saharan Africa was investigated for anti-plasmodial and anti-inflammatory activities.
  22. Dörnenburg H, Frickinger P, Seydel P. Plant cell-based processes for cyclotides production. J Biotechnol. 2008;135:123-6 pubmed publisher
    ..Callus, suspension cultures and hydroponic plants of Oldenlandia affinis were established and have been evaluated for effective cyclotides production processes...
  23. Mikula K, Tascón I, Tommila J, Iwai H. Segmental isotopic labeling of a single-domain globular protein without any refolding step by an asparaginyl endopeptidase. FEBS Lett. 2017;591:1285-1294 pubmed publisher
    ..This simple protein ligation approach using an AEP could be applied for incorporation of various biophysical probes into proteins as well as post-translational production of full-length proteins. ..
  24. Zhou Y, Wu K, Zeng G, Tan J, Xu K, Li F, et al. [Studies on constituents of Oldenlandia diffusa]. Zhongguo Zhong Yao Za Zhi. 2007;32:590-3 pubmed
    To investigate the chemical constituents of Oldenlandia diffusa.
  25. Qin Q, McCallum E, Kaas Q, Suda J, Saska I, Craik D, et al. Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics. 2010;11:111 pubmed publisher
    ..Their high stability has motivated their development as scaffolds for the stabilisation of peptide drugs. Oldenlandia affinis is a member of the Rubiaceae (coffee) family from which 18 cyclotides have been sequenced to date, but ..
  26. Lu W, Zhu Z, Guo Q, Ning Z, Feng S, Cao Y. [Seed quality test methods of Oldenlandia diffusa]. Zhongguo Zhong Yao Za Zhi. 2012;37:1366-71 pubmed
    To optimize the testing methods for seed quality, and provide basis for establishing seed testing rules and seed quality standard of Oldenlandia diffusa.
  27. Guo X, Wang R, Simmons M, But P, Yu J. Phylogeny of the Asian Hedyotis-Oldenlandia complex (Spermacoceae, Rubiaceae): evidence for high levels of polyphyly and the parallel evolution of diplophragmous capsules. Mol Phylogenet Evol. 2013;67:110-22 pubmed publisher
    Generic delimitation in the Hedyotis-Oldenlandia complex has a long taxonomically confused history because of the controversy of lumping or splitting these two taxa...
  28. Lau C, Mooiman K, Maas Bakker R, Beijnen J, Schellens J, Meijerman I. Effect of Chinese herbs on CYP3A4 activity and expression in vitro. J Ethnopharmacol. 2013;149:543-9 pubmed publisher
    ..Currently, only a few possible PK interactions between Chinese herbs and conventional Western drugs have been documented...
  29. Koehbach J, O Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott A, et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A. 2013;110:21183-8 pubmed publisher
    ..They were originally discovered in Oldenlandia affinis based on their use in traditional African medicine to accelerate labor...
  30. Goransson U, Craik D. Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. J Biol Chem. 2003;278:48188-96 pubmed
    ..This is the first direct chemical determination of disulfides in native cyclotides and unambiguously confirms the unique cyclic cystine knot motif...
  31. Wu P, Chi Shing Tai W, Liang Z, Zhao Z, Hsiao W. Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. Life Sci. 2009;85:113-21 pubmed publisher
    b>Oldenlandia diffusa (Willd.) Roxb. (O. diffusa) is a commonly used traditional Chinese medicine for treating cancer. Its pharmacological activities and anti-cancer effects have been the focus of intense research in recent years...
  32. Dörnenburg H. Progress in kalata peptide production via plant cell bioprocessing. Biotechnol J. 2009;4:632-45 pubmed publisher
    ..It is conceivable that plant-based production systems may ultimately prove to be the preferred route for the production of native or designed cyclotides, and will contribute towards the development of target-specific drugs...
  33. Dörnenburg H. Cyclotide synthesis and supply: from plant to bioprocess. Biopolymers. 2010;94:602-10 pubmed publisher
    ..This review highlights current research aimed at production routes of cyclotides in Oldenlandia affinis plantlets and cell cultures, and summarizes recent advances in bioprocessing aspects, with particular ..
  34. Henriques S, Huang Y, Rosengren K, Franquelim H, Carvalho F, Johnson A, et al. Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. J Biol Chem. 2011;286:24231-41 pubmed publisher
    ..We further show that the anti-HIV activity of kB1 is the result of its ability to target and disrupt the membranes of HIV particles, which are raft-like membranes very rich in PE-phospholipids...
  35. Sewani Rusike C, Gundidza M. Antifertility effects of Oldenlandia affinis in male rats - a preliminary study. Afr J Tradit Complement Altern Med. 2011;8:425-8 pubmed
    Antifertility effects of an aqueous leaf extract of Oldenlandia affinis on male rats were investigated...
  36. Kim S, Kim Y, Kim D, Jeon Y, Kim M, Kim H, et al. Oldenlandia diffusa Ameliorates Dextran Sulphate Sodium-Induced Colitis Through Inhibition of NF-?B Activation. Am J Chin Med. 2011;39:957-69 pubmed publisher
    Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Oldenlandia diffusa (OD) has been used as a traditional oriental medicine for inflammation...
  37. Ovesen R, Goransson U, Hansen S, Nielsen J, Hansen H. A liquid chromatography-electrospray ionization-mass spectrometry method for quantification of cyclotides in plants avoiding sorption during sample preparation. J Chromatogr A. 2011;1218:7964-70 pubmed publisher
    ..Cyclotides were extracted from candied violets, violet tea, and the plants Oldenlandia affinis and Viola odorata using 70% methanol containing 0.1% formic acid (v/v)...
  38. Gründemann C, Koehbach J, Huber R, Gruber C. Do plant cyclotides have potential as immunosuppressant peptides?. J Nat Prod. 2012;75:167-74 pubmed publisher
    ..Therefore, we chemically analyzed the crude extract of the coffee-family plant Oldenlandia affinis using a rapid peptidomics workflow utilizing nano-LC-MS, peptide reconstruct with database ..
  39. Lu W, Zhu Z, Guo Q, Feng S, Ning Z, Cao Y. [Quality classification criteria of Oldenlandia diffusa seeds]. Zhongguo Zhong Yao Za Zhi. 2012;37:1743-6 pubmed
    To establish the quality classification criteria of Oldenlandia diffusa seeds.
  40. Gruber C, Cemazar M, Mechler A, Martin L, Craik D. Biochemical and biophysical characterization of a novel plant protein disulfide isomerase. Biopolymers. 2009;92:35-43 pubmed publisher
    We recently isolated a protein disulfide isomerase (PDI) from the Rubiaceae (coffee family) plant Oldenlandia affinis (OaPDI) and demonstrated that it facilitates the production of disulfide-knotted defense proteins called cyclotides...
  41. Liang Z, He M, Fong W, Jiang Z, Zhao Z. A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential. Phytomedicine. 2008;15:259-67 pubmed publisher
    The herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of O. corymbosa (L...
  42. Ireland D, Wang C, Wilson J, Gustafson K, Craik D. Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90:51-60 pubmed
  43. Yadav S, Lee S. Evidence for Oldenlandia diffusa-evoked cancer cell apoptosis through superoxide burst and caspase activation. Zhong Xi Yi Jie He Xue Bao. 2006;4:485-9 pubmed
    b>Oldenlandia diffusa (Bai Hua She She Cao) is one of the herbs most commonly used in traditional Chinese medicine for treating cancer...
  44. Liang Z, Jiang Z, Leung K, Zhao Z. Determination of iridoid glucosides for quality assessment of Herba Oldenlandiae by high-performance liquid chromatography. Chem Pharm Bull (Tokyo). 2006;54:1131-7 pubmed
    Herba Oldenlandiae, the dried herb of Oldenlandia diffusa (WILLD.) ROXB. (Family Rubiaceae), is officially listed in the Chinese Pharmacopoeia. In the herbal market, two substitutes originated from O. corymbosa (L.) LAM and O...
  45. Mulvenna J, Sando L, Craik D. Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A. Structure. 2005;13:691-701 pubmed
    ..The 22 kDa precursor protein of tricyclon A was identified and provides clues to the processing of these fascinating miniproteins...
  46. Daly N, Clark R, Craik D. Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. J Biol Chem. 2003;278:6314-22 pubmed
  47. Singaravelu P, Shrishailappa B, Subban R. In vitro antioxidant activity of Oldenlandia herbacea and isolation of 9,9-dimethyl hexacosane and 23-ethyl-cholest-23-en-3beta-ol. Nat Prod Res. 2008;22:1510-5 pubmed publisher
    The petroleum ether, chloroform, ethyl acetate and methanol extracts of the whole plant of Oldenlandia herbacea were screened for in vitro antioxidant activity by using ABTS, DPPH, nitric oxide and hydrogen peroxide assay methods...
  48. Conlan B, Gillon A, Barbeta B, Anderson M. Subcellular targeting and biosynthesis of cyclotides in plant cells. Am J Bot. 2011;98:2018-26 pubmed publisher
    The cyclotide kalata B1 is found in the leaves of Oldenlandia affinis and is a potent insecticidal and nematocidal molecule...
  49. Plan M, Rosengren K, Sando L, Daly N, Craik D. Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. Biopolymers. 2010;94:647-58 pubmed publisher
    ..three-dimensional structure, and hemolytic activity of the cyclotide kalata B5 from the African plant Oldenlandia affinis...
  50. Craik D, Mylne J, Daly N. Cyclotides: macrocyclic peptides with applications in drug design and agriculture. Cell Mol Life Sci. 2010;67:9-16 pubmed publisher
    ..This article identifies gaps in current knowledge on cyclotides and suggests future directions for research into this fascinating family of ultra-stable mini-proteins...
  51. Chung H, Jeong H, Hong S, Kim M, Kim S, Song B, et al. Induction of nitric oxide synthase by Oldenlandia diffusa in mouse peritoneal macrophages. Biol Pharm Bull. 2002;25:1142-6 pubmed
    b>Oldenlandia diffusa (OD) has been used to treat malignant tumors. In this study using mouse peritoneal macrophages, we have examined the mechanism by which OD regulates nitric oxide (NO) production...
  52. Wang C, Wacklin H, Craik D. Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. J Biol Chem. 2012;287:43884-98 pubmed publisher
    ..At higher concentrations of cyclotides, destabilization of membranes occurs. Our results provide significant mechanistic insight into how cyclotides exert their bioactivities...
  53. Lu H. [Origin confirmation of a new natural product from Oldenlandia diffusa]. Zhong Yao Cai. 1998;21:299-301 pubmed
    A new natural product, 4,4'-dihydroxy-a-truxillic acid (I) was isolated from Oldenlandia diffusa (Willd) Roxb. I is a derivate of cyclobutane, which were obtained chemically by photochemical reaction...
  54. Kang S, Yoon S, Roh D, Jeon M, Seo H, Uh D, et al. The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. J Pharm Pharmacol. 2008;60:1347-54 pubmed publisher
    ..In this study, we examined the possible suppressive effect of UA extracted from Oldenlandia diffusa on zymosan-induced acute inflammation in mice and complete Freund's adjuvant (CFA)-induced arthritis in ..
  55. Senthilkumar B, Kumar P, Rajasekaran R. In-Silico Template Selection of In-Vitro Evolved Kalata B1 of Oldenlandia Affinis for Scaffolding Peptide-Based Drug Design. J Cell Biochem. 2016;117:66-73 pubmed publisher
    Structural stability of Oldenlandia affinis cyclotide, kalata B1 of native (1NB1) and two mutants 2F2I ([P20D, V21K] kB1) and 2F2J ([W19K, P20N, V21K] kB1) was investigated...
  56. Zhu T, Row K. Preparation of amino-modified active carbon cartridges and their use in the extraction of quercetin from Oldenlandia diffusa. J Pharm Biomed Anal. 2011;56:713-20 pubmed publisher
    ..as modifiers were bonded on active carbon (AC) surface for specific selective extraction of quercetin from Oldenlandia diffusa...
  57. Huang Y, Colgrave M, Daly N, Keleshian A, Martinac B, Craik D. The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores. J Biol Chem. 2009;284:20699-707 pubmed publisher
    ..Collectively, the findings provide a mechanistic explanation for the diversity of biological functions ascribed to this fascinating family of ultrastable macrocyclic peptides...
  58. Liu W, Shen D, Song P, Xu X. Clinical observation in 86 cases of acne vulgaris treated with Compound Oldenlandis Mixture. J Tradit Chin Med. 2003;23:255-6 pubmed
    ..01), and also in the total effective rate between the two groups significant (P < 0.05). It may be concluded that the Compound Oldenlandis Mixture is a better agent for the illness...
  59. Liang Z, Jiang Z, Ho H, Zhao Z. Comparative analysis of Oldenlandia diffusa and its substitutes by high performance liquid chromatographic fingerprint and mass spectrometric analysis. Planta Med. 2007;73:1502-8 pubmed
    Herba Oldenlandiae is the dried whole herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) recorded in the Chinese pharmacopoeia. However, the herbs of O. corymbosa (L.) Lam and O. tenelliflora Bl...
  60. Shan B, Zhang J, Du X. [Immunomodulatory activity and anti-tumor activity of Oldenlandia diffusa in vitro]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21:370-4 pubmed
    To study the effect of Oldenlandia diffusa (OD) on lymphocytes and tumor cells in vitro.
  61. Pan R, Guo F, Lu H, Feng W, Liang Y. Development of the chromatographic ?ngerprint of Scutellaria barbata D. Don by GC-MS combined with Chemometrics methods. J Pharm Biomed Anal. 2011;55:391-6 pubmed publisher
    ..The constituents of essential oil of Scutellaria barbata D. Don (SB) and its two adulterants Oldenlandia diffusa (OD) and Lobelia chinensis Lour (LCL) were analyzed and compared, 50, 36 and 38 components were ..
  62. Chen Y, Yao Z, Dai Y, Cheng H, Wen L, Zhou G, et al. [Study on HPLC fingerprint of Oldenlandia diffusa]. Zhong Yao Cai. 2012;35:886-92 pubmed
    To establish the HPLC fingerprint chromatogram of Oldenlandia diffusa coupled with chemometrics means for the quality control of multi-batches of medicinal material.
  63. Song Y, Jeong S, Kwon H, Kim B, Kim S, Yoo D. Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. Biol Pharm Bull. 2012;35:1022-8 pubmed
    Although ursolic acid isolated from Oldenlandia diffusa (Rubiaceae) was known to have anticancer activities in prostate, breast and liver cancers, the underlying mechanism of ursolic acid in ovarian cancer cells was not investigated so ..