hedyotis

Summary

Summary: A plant genus of the family RUBIACEAE. Members contain anthraquinones and iridoids. H. diffusa is used in DRUGS, CHINESE HERBAL.

Top Publications

  1. Liu X, Gao S, Li X, Li H. [Identification on Herba Hedyotidis by HPLC fingerprint pattern method]. Zhong Yao Cai. 2005;28:91-4 pubmed
    ..To establish a new identification and analysis method of Herba Hedyotidis...
  2. Li C, Xue X, Zhou D, Zhang F, Xu Q, Ren L, et al. Analysis of iridoid glucosides in Hedyotis diffusa by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2008;48:205-11 pubmed publisher
    An HPLC-DAD-ESI-MS/MS method was developed for analysis of iridoid glucosides (IGs) from Hedyotis diffusa Willd...
  3. Lin J, Wei L, Xu W, Hong Z, Liu X, Peng J. Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis. Mol Med Rep. 2011;4:1283-8 pubmed publisher
    ..b>Hedyotis Diffusa Willd (EEHDW) has long been used as an important component in several TCM formulas to treat various types ..
  4. Mishra K, Dash A, Swain B, Dey N. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar J. 2009;8:26 pubmed publisher
    Herbal extracts of Andrographis paniculata (AP) and Hedyotis corymbosa (HC) are known as hepato-protective and fever-reducing drugs since ancient time and they have been used regularly by the people in the south Asian sub-continent...
  5. Ahmad R, Shaari K, Lajis N, Hamzah A, Ismail N, Kitajima M. Anthraquinones from Hedyotis capitellata. Phytochemistry. 2005;66:1141-7 pubmed
    ..ether, alizarin 1-methyl ether and digiferruginol, together with scopoletin were isolated from the stems of Hedyotis capitellata Wall (Rubiaceae). Lucidin-3-O-beta-glucoside was isolated from the roots of the plant...
  6. Wong C, Taichi M, Nishio H, Nishiuchi Y, Tam J. Optimal oxidative folding of the novel antimicrobial cyclotide from Hedyotis biflora requires high alcohol concentrations. Biochemistry. 2011;50:7275-83 pubmed publisher
    Hedyotide B1, a novel cyclotide isolated from the medicinal plant Hedyotis biflora, contains a cystine knot commonly found in toxins and plant defense peptides...
  7. Niu Y, Meng Q. Chemical and preclinical studies on Hedyotis diffusa with anticancer potential. J Asian Nat Prod Res. 2013;15:550-65 pubmed publisher
    This paper presents the chemical and preclinical anticancer research on Hedyotis diffusa Willd. in detail, one of the most renowned herbs often prescribed in the polyherbal formulas for cancer treatment in traditional Chinese medicine...
  8. Yuan N, Sun Y, Nakamura K, Qiu Y. Development of microsatellite markers in heterostylous Hedyotis chrysotricha (Rubiaceae). Am J Bot. 2012;99:e43-5 pubmed publisher
    Microsatellite primers were developed for a heterostylous herb, Hedyotis chrysotricha to investigate the effect of habitat fragmentation on its genetic diversity and population structure.
  9. Sadasivan S, Latha P, Sasikumar J, Rajashekaran S, Shyamal S, Shine V. Hepatoprotective studies on Hedyotis corymbosa (L.) Lam. J Ethnopharmacol. 2006;106:245-9 pubmed
    b>Hedyotis corymbosa is used in traditional medicine of India and China to treat various hepatic disorders...

More Information

Publications87

  1. Lin C, Kuo C, Lee M, Hsu S, Huang A, Tang N, et al. Extract of Hedyotis diffusa Willd influences murine leukemia WEHI-3 cells in vivo as well as promoting T- and B-cell proliferation in leukemic mice. In Vivo. 2011;25:633-40 pubmed
    ..b>Hedyotis diffusa Willd (HDW) has been known as a traditional Chinese medicine for a long time, and possesses various ..
  2. Lee H, Bau D, Kuo C, Tsai R, Chen Y, Chang Y. Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. Am J Chin Med. 2011;39:201-13 pubmed
    b>Hedyotis diffusa Willd. (Rubiaceae) is an important folk herb used to prevent and cure hepatitis and liver cancer in Taiwan. For differentiation of H. diffusa from counterfeits, macroscopic and microscopic characters of H. diffusa, H...
  3. Lin J, Chen Y, Wei L, Chen X, Xu W, Hong Z, et al. Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. Int J Oncol. 2010;37:1331-8 pubmed
    b>Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer...
  4. Ahmad R, Ali A, Israf D, Ismail N, Shaari K, Lajis N. Antioxidant, radical-scavenging, anti-inflammatory, cytotoxic and antibacterial activities of methanolic extracts of some Hedyotis species. Life Sci. 2005;76:1953-64 pubmed
    ..subtilis B28, MRSA and P. aeruginosa only. The roots of H. dichotoma showed strong antibacterial activity against all 4 bacteria. All other extracts did not exhibit any antibacterial activity...
  5. Wu X, Li A, Zhang D. Cryptic self-incompatibility and distyly in Hedyotis acutangula Champ. (Rubiaceae). Plant Biol (Stuttg). 2010;12:484-94 pubmed publisher
    ..we report an unusual kind of distyly associated with self- and/or intramorph compatibility in a perennial herb, Hedyotis acutangula. Floral morphology, ancillary dimorphisms and compatibility of the two morphs were studied. H...
  6. Tu X, Deng Y, Chen J, Hu Q, He C, Jordan J, et al. Screening study on the anti-angiogenic effects of Traditional Chinese Medicine - Part I: Heat-clearing and detoxicating TCM. J Ethnopharmacol. 2016;194:280-287 pubmed publisher
    ..TCM (Philippine Violet Herb, Wild Chrysanthemum, Heartleaf Houttuynia Herb, Chinese Lobelia Herb, Spreading Hedyotis Herb and Uniflower Swisscentaury Root) were decocted, concentrated, sieved and desiccated to attain the water ..
  7. Zhang L, Zhang J, Qi B, Jiang G, Liu J, Zhang P, et al. The anti-tumor effect and bioactive phytochemicals of Hedyotis diffusa willd on ovarian cancer cells. J Ethnopharmacol. 2016;192:132-139 pubmed publisher
    b>Hedyotis diffusa willd (HDW) is a widely used medicinal herb in China. It processed various medicinal properties including antioxidative, anti-inflamatory and anti-cancer effects...
  8. Martins D, Nunez C. Secondary metabolites from Rubiaceae species. Molecules. 2015;20:13422-95 pubmed publisher
    ..These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda...
  9. He J, Li J, Liu H, Yang Z, Zhou F, Wei T, et al. Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-?B and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher
    The iridoids of Hedyotis diffusa Willd play an important role in the anti-inflammatory process, but the specific iridoid with anti-inflammatory effect and its mechanism has not be thoroughly studied...
  10. Yan Z, Feng J, Peng J, Lai Z, Zhang L, Jin Y, et al. Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways. Oncol Lett. 2017;14:7923-7930 pubmed publisher
    i>Hedyotis diffusa Willd (HDW) is a widely used traditional Chinese medicine in clinical therapy to treat various types of cancer, including colorectal cancer (CRC), but its effective polar fractions and functional mechanisms remain ..
  11. Kuo Y, Lin J, Hsiao Y, Chou G, Tsai Y, Chiang S, et al. Ethanol Extract of Hedyotis diffusa Willd Affects Immune Responses in Normal Balb/c Mice In Vivo. In Vivo. 2015;29:453-60 pubmed
    Numerous clinical anticancer drugs are obtained from natural plants and Hedyotis diffusa Willd (EEHDW) has been used as a major component in Traditional Chinese medicine formulas since a long time...
  12. Tao G, Balunas M. Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research. J Ethnopharmacol. 2016;182:170-80 pubmed publisher
    ..barbata more often than Nanjing practitioners (p<0.05). Hedyotis diffusa was found to be the most commonly cited herb to pair with S. barbata for cancer treatment (p<0.05)...
  13. Neupane S, Lewis P, Dessein S, Shanks H, Paudyal S, Lens F. Evolution of woody life form on tropical mountains in the tribe Spermacoceae (Rubiaceae). Am J Bot. 2017;104:419-438 pubmed publisher
    ..Three of the largest woody lineages (Arcytophyllum, Hedyotis, and Kadua) are characterized by their distribution in the moist tropical mountains and have disjunct ..
  14. Chen M, May B, Zhou I, Xue C, Zhang A. Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer: Contributions of Specific Plants to Tumor Response. Integr Cancer Ther. 2016;15:40-59 pubmed publisher
    ..Specific combinations of TMs appeared to produce higher contributions to TRR than the TMs individually. Notable among these was the combination of Hedyotis, Astragalus, and Scutellaria.
  15. Hoang Anh N, Tam K, Tuan N, Thien D, Quan T, Tam N, et al. Chemical constituents of Oldenlandia pinifolia and their antiproliferative activities. Nat Prod Res. 2017;:1-7 pubmed publisher
    This study describes the chemical constituents of Oldenlandia pinifolia (Wall. Ex G. Don) Kuntze (synonym Hedyotis pinifolia Wall. Ex G. Don) and discusses their anti-proliferative activities...
  16. Li S, Lin Z, Jiang H, Tong L, Wang H, Chen S. Rapid Identification and Assignation of the Active Ingredients in Fufang Banbianlian Injection Using HPLC-DAD-ESI-IT-TOF-MS. J Chromatogr Sci. 2016;54:1225-37 pubmed publisher
    ..Don and 38 compounds were from Hedyotis diffusa Willd...
  17. Li J, Zhou G, Li C, Wen P, Ying P, Yu J, et al. [Determination of scandoside methyl ester in Hedyotis chrysotricha by HPLC]. Zhongguo Zhong Yao Za Zhi. 2009;34:2619-21 pubmed
    To develop an HPLC method for determination of scandoside methyl ester in Hedyotis chrysotricha...
  18. Jiang J, Wang B, Li J, Ye B, Lin S, Qian W, et al. Total coumarins of Hedyotis diffusa induces apoptosis of myelodysplastic syndrome SKM-1 cells by activation of caspases and inhibition of PI3K/Akt pathway proteins. J Ethnopharmacol. 2017;196:253-260 pubmed publisher
    b>Hedyotis diffusa is an ethno-medicine used for anti-cancer treatment in the clinic of traditional Chinese medicine (TCM)...
  19. Li D, Zheng X, Duan L, Deng S, Ye W, Wang A, et al. Ethnobotanical survey of herbal tea plants from the traditional markets in Chaoshan, China. J Ethnopharmacol. 2017;205:195-206 pubmed publisher
    ..The most cited species were Hedyotis corymbosa (L.) Lam. (47 times mentioned), Hedyotis diffusa Willd. (46), Plantago asiatica L...
  20. Zhou Y, Weng X, Dou R, Tan X, Zhang T, Fang J, et al. Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice. Acta Pharmacol Sin. 2017;38:201-210 pubmed publisher
    b>Hedyotis hedyotidea has been used in traditional Chinese medicine for the treatment of autoimmune diseases. However, the mechanisms underlying for the effect remain unknown...
  21. Wang C, Xin P, Wang Y, Zhou X, Wei D, Deng C, et al. Iridoids and sfingolipids from Hedyotis diffusa. Fitoterapia. 2018;124:152-159 pubmed publisher
    Seven new compounds were isolated from the aerial part of Hedyotis diffusa, including three iridoid glycosides, hedyoiridoidside A - C (1-3), two cerebrosides, hedyocerenoside F (4) and G (5), and two new ceramides, hedyoceramide A (6) ..
  22. Lin C, Ng L, Yang J, Hsu Y. Anti-inflammatory and hepatoprotective activity of peh-hue-juwa-chi-cao in male rats. Am J Chin Med. 2002;30:225-34 pubmed
    Peh-hue-juwa-chi-cao (PHJCC) is a common commercial name for the herbal extract of either Hedyotis diffusa (HD), H. corymbosa (HC), or Mollugo pentaphylla (MP)...
  23. Xu G, Kim Y, Chi S, Choo S, Ryoo I, Ahn J, et al. Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Bioorg Med Chem Lett. 2010;20:513-5 pubmed publisher
    Five iridoid glycosides were isolated from the MeOH extract of Hedyotis diffusa, and their structures were elucidated as E-6-O-p-methoxycinnamoyl scandoside methyl ester (1), Z-6-O-p-methoxycinnamoyl scandoside methyl ester (2), E-6-O-p-..
  24. Xu H, Xu H. Analysis of trace elements in Chinese therapeutic foods and herbs. Am J Chin Med. 2009;37:625-38 pubmed
    ..Further studies should also be considered in relation to Sr, Zn and blood regulating herbs, which could prove to be beneficial. ..
  25. Wang Z, Gao K, Xu C, Gao J, Yan Y, Wang Y, et al. Metabolic effects of Hedyotis diffusa on rats bearing Walker 256 tumor revealed by NMR-based metabolomics. Magn Reson Chem. 2018;56:5-17 pubmed publisher
    b>Hedyotis diffusa, a traditional Chinese herbal medicine, is widely used for oncotherapy and shows a positive effect in the clinical treatment. But its mechanism of anticancer activities is complicated and unclear...
  26. Van Long L, Nga V, Dam N, Hung M, Dung T, Quang T, et al. Three new iridoid glucoside salts from Hedyotis tenelliflora Growing in Vietnam. Nat Prod Commun. 2013;8:1507-8 pubmed
    ..deacetylasperulosidic acid sodium salt (1), teneoside D (2), and teneoside E (3) were isolated from the leaves of Hedyotis tenelliflora Blume (Rubiaceae), together with seven known iridoids, 6alpha-hydroxygeniposide (4), 6beta-..
  27. Huang K, Yen H, Chiang J, Su Y, Sun M, Chang H, et al. Chinese Herbal Medicine as an Adjunctive Therapy Ameliorated the Incidence of Chronic Hepatitis in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study. Evid Based Complement Alternat Med. 2017;2017:1052976 pubmed publisher
    ..single herbs and formulas were effective in protecting liver function in patients with breast cancer, where Hedyotis diffusa and Jia-Wei-Xiao-Yao-San were the most commonly used herbal agents...
  28. Li Q, Lai Z, Yan Z, Peng J, Jin Y, Wei L, et al. Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5?FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. Mol Med Rep. 2017;: pubmed publisher
    b>Hedyotis diffusa Willd (HDW) is a major component frequently used in Traditional Chinese Medicine for the clinical treatment of colorectal cancer (CRC) and its associated drug resistance...
  29. Wang C, Zhou X, Wang Y, Wei D, Deng C, Xu X, et al. The Antitumor Constituents from Hedyotis Diffusa Willd. Molecules. 2017;22: pubmed publisher
    As a TCM, Hedyotis diffusa Willd. has been using to treat malignant tumors, and many studies also showed that the extracts from Hedyotis diffusa Willd. possessed evident antitumor activities...
  30. Wang N, Li D, Niu H, Zhang Y, He P, Wang J. 2-hydroxy-3-methylanthraquinone from Hedyotis diffusa Willd induces apoptosis in human leukemic U937 cells through modulation of MAPK pathways. Arch Pharm Res. 2013;36:752-8 pubmed publisher
    The herb of Hedyotis diffusa Willd (H. diffusa Willd), an annual herb distributed in northeastern Asia, has been known as a traditional oriental medicine for the treatment of cancer...
  31. Zhang C, Guo X, Bao L, Qin F, Li F. [Determination of p-coumaric acid in Hedyotis diffusa Willd. from different sources by reversed-phase high performance liquid chromatography]. Se Pu. 2005;23:180-2 pubmed
    A method for the determination of p-coumaric acid in Hedyotis diffusa Willd. from different sources by reversed-phase high performance liquid chromatography (RP-HPLC) has been developed...
  32. Liu Z, Liu M, Liu M, Li J. Methylanthraquinone from Hedyotis diffusa WILLD induces Ca(2+)-mediated apoptosis in human breast cancer cells. Toxicol In Vitro. 2010;24:142-7 pubmed publisher
    Methylanthraquinone from Hedyotis diffusa WILLD exhibited potent anticancer activity in many kinds of cancer cells...
  33. Joseph J, Sowndhararajan K, Manian S. Evaluation of analgesic and anti-inflammatory potential of Hedyotis puberula (G. Don) R. Br. ex Arn. in experimental animal models. Food Chem Toxicol. 2010;48:1876-80 pubmed publisher
    b>Hedyotis puberula (G. Don) R. Br. ex Arn. is used for the treatment of several ailments in the traditional system of medicine...
  34. Liu X, Li H, Xu H, Qian J. [Identification on Herba Hedyotidis by X-ray diffraction Fourier fingerprint pattern method]. Zhong Yao Cai. 2003;26:488-90 pubmed
    ..To establish a new identification and analysis method of Herba Hedyotidis...
  35. Xie Z, Zhang Y, Lu R. [Identification of herba hedyotis diffusae and its confused material Herba Hedyotis pinifoliae]. Zhong Yao Cai. 1997;20:287-90 pubmed
    This article has reported the results of the study on the outer properties, inter organization and TLC of Herba Hedyotis Diffuse and its confused material Herba Hedyotis Pinifoliae...
  36. Chen Y, Chang F, Wu C, Yen M, Liaw C, Huang H, et al. New cytotoxic 6-oxygenated 8,9-dihydrofurocoumarins, hedyotiscone A - C, from Hedyotis biflora. Planta Med. 2006;72:75-8 pubmed
    ..8,9-dihydrofurocoumarin-type compounds, hedyotiscones A, B, and C were isolated from the methanol extract of Hedyotis biflora together with seven known compounds...
  37. Jiang Z, Xu H, Zhao Y, Yu M. Determination of 3,4-Dihydroxy Methyl Benzoate in Rat Plasma by HPLC and Its Pharmacokinetics. J Chromatogr Sci. 2016;54:144-7 pubmed publisher
    ..32 ± 0.04) L and CL (5.79 ± 0.82) mL min(-1). The method is proven to be suitable for the pharmacokinetic study of 3,4-dihydroxy methyl benzoate, which offers the advantage of simplicity, sensitivity and accuracy. ..
  38. Shi Y, Wang C, Gong X. Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD. Biol Pharm Bull. 2008;31:1075-8 pubmed
    Two anthraquinones which inhibit activity of the Src tyrosine kinase were isolated from a water extract of Hedyotis diffusa WILLD...
  39. Zhang H, Chen Y, Huang R. [Study on flavonoids from Hedyotis diffusa Willd]. Zhong Yao Cai. 2005;28:385-7 pubmed
    Five flavonoids were isolated from Hedyotis diffusa Willd...
  40. Liu Z, Hao M, Wang J. [Application of allele-specific primer in the identificatin of Hedyotis diffusa]. Zhong Yao Cai. 2004;27:484-7 pubmed
    To develop a convenient and effective method for the identification of Hedyotis diffusa.
  41. Xie Y, Hang T, Cheng Z, Zhang Z, An D. [HPLC determination of oleanolic acid and llrolic acid in Chinese medicinal herbs]. Zhongguo Zhong Yao Za Zhi. 2001;26:615-6 pubmed
    ..To develop a new method for simultaneous determination of oleanolic acid and llrolic acid in Chinese medicinal herbs at the same time...
  42. Huang W, Li Y, Jiang J. [Chemical constituents from Hedyotis diffusa]. Zhongguo Zhong Yao Za Zhi. 2009;34:712-4 pubmed
    To investigate the chemical constituents from Hedyotis diffusa.
  43. Wang J, Shu L, Yang L, Zhang M, He P. 2-Hydroxy-3-methylanthraquinone from Hedyotis diffusa WILLD induces apoptosis via alteration of Fas/FasL and activation of caspase-8 in human leukemic THP-1 cells. Arch Med Res. 2011;42:577-83 pubmed publisher
    Numerous studies have shown that Hedyotis diffusa WILLD (H. diffusa) could promote apoptosis in several cancer cell lines. However, the cellular and molecular mechanisms responsible for this phenomenon are still poorly understood...
  44. Wang X, Cheng W, Yao X, Guo X. Qualitative analysis of the chemical constituents in Hedyotis diffusa by HPLC-TOF-MS. Nat Prod Res. 2012;26:167-72 pubmed publisher
    ..spectrometry (HPLC-TOF-MS) method was developed for analysing the chemical constituents in Hedyotis diffusa, which is widely used as a traditional Chinese medicine (TCM) in the field of cancer treatment...
  45. Zhang Y, Luo J. [Analysis of the chemical constituents of Hedyotis diffusa]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28:127-8 pubmed
    To analyze the chemical constituents of Hedyotis diffusa.
  46. Yuan N, Comes H, Mao Y, Qi X, Qiu Y. Genetic effects of recent habitat fragmentation in the Thousand-Island Lake region of southeast China on the distylous herb Hedyotis chrysotricha (Rubiaceae). Am J Bot. 2012;99:1715-25 pubmed publisher
    ..Here, we studied a distylous herb, Hedyotis chrysotricha (Rubiaceae), in the artificially created Thousand-Island Lake (TIL) region of southeast China to ..
  47. Zhang P, Zhang B, Gu J, Hao L, Hu F, Han C. The Study of the Effect of Hedyotis diffusa on the Proliferation and the Apoptosis of the Cervical Tumor in Nude Mouse Model. Cell Biochem Biophys. 2015;72:783-9 pubmed publisher
    To study the inhibitory effect of Hedyotis diffusa on cervical cancer and its underlining biomolecular mechanism...
  48. Yang Y, Wei M, Chiu H, Huang T. Development and validation of a modified ultrasound-assisted extraction method and a HPLC method for the quantitative determination of two triterpenic acids in Hedyotis diffusa. Nat Prod Commun. 2013;8:1683-6 pubmed
    ..This report is valuable for the application of H. diffusa and H. corymbosa obtained from different regions in clinical research and pharmacology...
  49. Joseph J, Sowndhararajan K, Manian S. Protective effects of methanolic extract of Hedyotis puberula (G. Don) R. Br. ex Arn. against experimentally induced gastric ulcers in rat. J Ethnopharmacol. 2010;131:216-9 pubmed publisher
    This study was aimed to evaluate the antiulcer activity of the whole plants of Hedyotis puberula (G. Don) R. Br. ex Arn.
  50. Li M, Wong Y, Jiang L, Wong K, Wong Y, Lau C, et al. Application of novel loop-mediated isothermal amplification (LAMP) for rapid authentication of the herbal tea ingredient Hedyotis diffusa Willd. Food Chem. 2013;141:2522-5 pubmed publisher
    b>Hedyotis diffusa Willd. (Baihuasheshecao) is an ingredient of herbal teas commonly consumed in the Orient and tropical Asia for cancer treatment and health maintenance...
  51. Nimal Christhudas I, Praveen Kumar P, Sunil C, Vajravijayan S, Lakshmi Sundaram R, Jenifer Siril S, et al. In vitro studies on ?-glucosidase inhibition, antioxidant and free radical scavenging activities of Hedyotis biflora L. Food Chem. 2013;138:1689-95 pubmed publisher
    ..the in vitro ?-glucosidase inhibition and antioxidant activity of hexane, ethyl acetate and methanol extracts of Hedyotis biflora L. (Rubiaceae)...
  52. Ji S, Fattahi A, Raffel N, Hoffmann I, Beckmann M, Dittrich R, et al. Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria. Eur J Med Res. 2017;22:50 pubmed publisher
    ..The aqueous extracts of Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria rhizome were prepared and then their effects on copper-induced low-density ..
  53. Kang X, Li X, Zhao C, Mao Y. Two new anthraquinones from Hedyotis diffusa W. J Asian Nat Prod Res. 2008;10:193-7 pubmed publisher
    Two new anthraquinones, 2,6-dihydroxy-3-methyl-4-methoxyanthraquinone (1) and 2-hydroxy-7-hydroxymethyl-3-methoxyanthraquinone (2), were isolated from Hedyotis diffusa W. Their structures were elucidated by means of spectroscopic evidence.
  54. Zhang F, Guo Z, Zhang F, Xue X, Liang X. [Selective enrichment of iridoid glucosides in Hedyotis diffusa Willd. by tandem solid phase extraction]. Se Pu. 2009;27:436-41 pubmed
    A method for selective enrichment of iridoid glucosides in Hedyotis diffusa Willd. by tandem solid phase extraction (SPE) was developed. Oligo(ethylene glycol) (OEG) is a novel type of separation material made in this laboratory...
  55. You B, Wu Y, Wu C, Bao B, Chen M, Chang Y, et al. Proteomics displays cytoskeletal proteins and chaperones involvement in Hedyotis corymbosa-induced photokilling in skin cancer cells. Exp Dermatol. 2011;20:653-8 pubmed publisher
    ..This study demonstrated that 80 ?g/ml Hedyotis corymbosa extracts with 0.8 J/cm(2) fluence dose caused M21 skin cancer cell death. Photoactivated H...
  56. Huang W, Yu S, Li Y, Jiang J. Four anthraquinones from Hedyotis diffusa. J Asian Nat Prod Res. 2008;10:887-9 pubmed publisher
    A new anthraquinone has been isolated from the 95% EtOH extract of Hedyotis diffusa and characterized as 2-hydroxy-3-methoxy-6-methyl-9,10-anthraquinone (1) by extensive spectral analysis...
  57. Lin J, Wei L, Shen A, Cai Q, Xu W, Li H, et al. Hedyotis diffusa Willd extract suppresses Sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis. Int J Oncol. 2013;42:651-6 pubmed publisher
    ..b>Hedyotis diffusa Willd (HDW), as a well-known traditional Chinese herbal medicine, has long been used in China for the ..
  58. Ye M, Su J, Liu S, Cao L, Xiong J, Zhao Y, et al. (24S)-ergostane-3?,5?,6?-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells. Nat Prod Res. 2013;27:1136-40 pubmed publisher
    The methanol extract of the whole plant of Hedyotis chrysotricha demonstrated cytotoxicity against SK-HEP-1 human hepatocarcinoma cells in a primary screening for novel antitumour agents...
  59. Yan L, Wang Y, Yu Q. [HPLC-TOF-MS analysis of metabolites of Diffusa effective extracts in rats]. Zhongguo Zhong Yao Za Zhi. 2011;36:1301-4 pubmed
    ..To analyze p-coumaril acid, trans-6-O-p-coumaroyl scandoside methyl ester and its metabolites in rat plasma after intragastric administration of exocarpium Diffusa effective extracts...
  60. Yue G, Kin Ming Lee J, Cheng L, Chung Lap Chan B, Jiang L, Fung K, et al. Reversal of P-glycoprotein-mediated multidrug resistance in human hepatoma cells by hedyotiscone A, a compound isolated from Hedyotis corymbosa. Xenobiotica. 2012;42:562-70 pubmed publisher
    ..Hedyotiscone A, a compound isolated from Chinese herbal medicine Hedyotis corymbosa (HC, family Rubiaceae), was used as the chemical marker to distinguish between HC and an anticancer ..
  61. Li C, Zhang X, Xue X, Zhang F, Xu Q, Liang X. Structural characterization of iridoid glucosides by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008;22:1941-54 pubmed publisher
    ..Based on the fragmentation patterns of these standard IGs, twelve IGs have been characterized in an extract of Hedyotis diffusa Willd...
  62. Lau C, Cheng L, Cheng B, Yue G, Wong E, Lau C, et al. Development of a simple chromatographic method for distinguishing between two easily confused species, Hedyotis diffusa and Hedyotis corymbosa. Nat Prod Res. 2012;26:1446-50 pubmed publisher
    b>Hedyotis diffusa Willd. and Hedyotis corymbosa (L.) Lam. are closely related species of Rubiaceae family and they can be easily confused...
  63. Guo Q, Wu C, Du X. [Observation on biological characteristics of Hedyotis diffusa]. Zhong Yao Cai. 2001;24:705-6 pubmed
    The present work enunciats the phenophase and plant organ development of Hedyotis diffusa Willd, at Nanjing region. These results can give a reference for the plant growing practice.
  64. Zhang H, Zhang H, Li Y, Guo X. [Simultaneous determination of four components in Hedyotis diffusa oral solution by reversed-phase HPLC]. Zhongguo Zhong Yao Za Zhi. 2008;33:2329-31 pubmed
    ..simultaneous determination of four methyl-3, 4-dihydroxybenzoate ( I ), P-coumaric acid (II), ferulaic acid (III) and E-6-O-P-coumaroyl scandoside methyl ester (IV) in Hedyotis diffusa oral solution by reversed-phase HPLC was developed.
  65. Chen Y, Xiong J, Huang M, Gu D. [Diversity and stability of arthropod assemblage in tea orchard]. Ying Yong Sheng Tai Xue Bao. 2004;15:875-8 pubmed
    ..simplex tea orchard with weeds removed manually or by herbicides (STO) and complex tea orchard with the weed Hedyotis uncinella (CTO), each with an area of 0...
  66. Nguyen G, Zhang S, Wang W, Wong C, Nguyen N, Tam J. Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. J Biol Chem. 2011;286:44833-44 pubmed publisher
    ..study, we report the discovery of two novel cyclotides, hedyotide B1 and hedyotide B2, from the aerial parts of Hedyotis biflora. Hedyotide B1 has a cyclic cystine knot structure typical of cyclotides...
  67. Cao L, Yu D, Wang X, Ke Y, Jin Y, Liang X. The development of an evaluation method for capture columns used in two-dimensional liquid chromatography. Anal Chim Acta. 2011;706:184-90 pubmed publisher
  68. Cui J, Wang S, Shi S, Wang Z. Structural characterization of a glucan isolated from Hedyotis diffusa Willd. Zhong Yao Cai. 2006;29:912-5 pubmed
    ..To isolate a homogeneous polysaccharide RP from RDP (a crude polysaccharide from Dioscorea opposita Thunb.), and study its preliminary com-position and structure...
  69. Chen X, Cao Z, Chen T, Zhang Y, Liu Z, Su Y, et al. Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway. Oncol Rep. 2012;28:742-8 pubmed publisher
    b>Hedyotis Diffusa Willd (HDW), a Chinese herbal medicine, has been widely used as an adjuvant therapy against various cancers, including hepatocellular carcinoma (HCC)...
  70. Yang T, Yang Y, Yang J, Chen B, Duan J, Yu S, et al. Fingerprint of Hedyotis diffusa Willd. by HPLC-MS. Phytochem Anal. 2008;19:487-92 pubmed publisher
    ..developed based on the consistent chromatographic features of the major chemical constituents among 10 batches of Hedyotis diffusa Willd...
  71. Wang G, Li T, Deng F, Li Y, Ye W. Five new phenolic glycosides from Hedyotis scandens. Bioorg Med Chem Lett. 2013;23:1379-82 pubmed publisher
    ..a new cyanogenic glycoside (1), along with 10 known compounds (6-15) were isolated from the whole plants of Hedyotis scandens...
  72. Guo X, Wang R, Simmons M, But P, Yu J. Phylogeny of the Asian Hedyotis-Oldenlandia complex (Spermacoceae, Rubiaceae): evidence for high levels of polyphyly and the parallel evolution of diplophragmous capsules. Mol Phylogenet Evol. 2013;67:110-22 pubmed publisher
    Generic delimitation in the Hedyotis-Oldenlandia complex has a long taxonomically confused history because of the controversy of lumping or splitting these two taxa...
  73. Zhang X, Ye B, Lin S. [Effects of Hedyotis diffusa Willd injection on the proliferation of RPMI 8226 cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32:1658-62 pubmed
    To explore the inhibition of Hedyotis diffusa Willd Injection (HDI) on the proliferation of RPMI 8226 cells and its mechanisms.
  74. Cheung H, Cheung S, Law M, Lai W. Simultaneous determination of key bioactive components in Hedyotis diffusa by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;834:195-8 pubmed
    ..important bioactive components (geniposidic acid, ursolic acid, quercetin and p-coumaric acid) in the extract of Hedyotis diffusa (HD). Separations were carried out in a fused-silica capillary tube with peak detection at 214 nm...
  75. Huang W, Li Y, Jiang J. [Chemical constituents from Hedyotis diffusa]. Zhongguo Zhong Yao Za Zhi. 2008;33:524-6 pubmed
    To investigate the chemical constituents from Hedyotis diffusa.
  76. Zhang Y, Luo J. [Studies on the chemical constituents in herb of Hedyotis diffusa]. Zhong Yao Cai. 2008;31:522-4 pubmed
    To study the chemical constituents of Hedyotis diffusa.
  77. Fan Y, Wen C, Xie Z. [Effects of three Chinese herbal antidotes (Herba artemisiae annuae, Herba hedyotis diffusae and Rhizoma cimicifugae) and their different combinations on regulated on activation normal T cell expressed and secreated expression in MRL/lpr mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:1306-9 pubmed
    To explore the effects of three Chinese herbal antidotes, i.e. Herba Artemisiae annuae (A), Herba Hedyotis diffusae (H) and Rhizoma Cimicifugae (C), all were ingredients of Jiedu Quyu Ziyin Recipe, for adjusting the regulated on ..
  78. Zhang Y, Chen Y, Fan C, Ye W, Luo J. Two new iridoid glucosides from Hedyotis diffusa. Fitoterapia. 2010;81:515-7 pubmed publisher
    Two new iridoid glucosides, named diffusosides A and B, were isolated from the aerial part of Hedyotis diffusa Willd. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis and HRESIMS...