cephaelis

Summary

Summary: A plant genus of the family RUBIACEAE, order Rubiales, subclass Asteridae. Cephaelis ipecacuanha is the source of IPECAC.

Top Publications

  1. Chaves Valadão A, Abreu C, Dias J, Arantes P, Verli H, Tanuri A, et al. Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity. Molecules. 2015;20:11474-89 pubmed publisher
    ..Taken together, our findings provide additional pharmacological information on the potential therapeutic effects of emetine. ..
  2. Tanahashi T. [Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts]. Yakugaku Zasshi. 2017;137:1443-1482 pubmed publisher
    ..Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids...
  3. Itoh A, Baba Y, Tanahashi T, Nagakura N. Tetrahydroisoquinoline-monoterpene glycosides from Cephaelis acuminata. Phytochemistry. 2002;59:91-7 pubmed
    From the dried roots of Cephaelis acuminata, five tetrahydroisoquinoline-monoterpene glycosides, 2-O-beta-D-glucopyranosyldemethylalangiside, demethylisoalangiside, 6"-O-beta-D-glucopyranosylipecoside, 6"-O-alpha-D-..
  4. Souza M, Martins E, Pereira T, Oliveira L. Reproductive studies on ipecac (Cephaelis ipecacuanha (Brot.) A. Rich; Rubiaceae): meiotic behavior and pollen viability. Braz J Biol. 2006;66:151-9 pubmed
    Reproductive studies were carried out on Brazilian accessions of ipecac, Cephaelis ipecacuanha. Meiotic behavior was studied using the squashing technique...
  5. Möller M, Wink M. Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines. Planta Med. 2007;73:1389-96 pubmed
    ..A new protein spot was apparent after treatment with emetine: It could be identified as the N-terminal fragment lamin B1, which is released after cleavage by caspase-6...
  6. Nomura T, Kutchan T. Three new O-methyltransferases are sufficient for all O-methylation reactions of ipecac alkaloid biosynthesis in root culture of Psychotria ipecacuanha. J Biol Chem. 2010;285:7722-38 pubmed publisher
    ..ipecacuanha could be explained by the enzymatic activities of IpeOMT1-IpeOMT3, indicating that they are sufficient for all O-methylation reactions of ipecac alkaloid biosynthesis...
  7. Berger A, Fasshuber H, Schinnerl J, Robien W, Brecker L, Valant Vetschera K. Iridoids as chemical markers of false ipecac (Ronabea emetica), a previously confused medicinal plant. J Ethnopharmacol. 2011;138:756-61 pubmed publisher
    ..Psychotria emetica). Besides its previous use as substitute of ipecac, the latter species is applied in traditional medicine of Panama and fruits of its relative Ronabea latifolia are reported as curare additives from Colombia...
  8. Manzali de Sá I, Elisabetsky E. Medical knowledge exchanges between Brazil and Portugal: an ethnopharmacological perspective. J Ethnopharmacol. 2012;142:762-8 pubmed publisher
    ..This "Brazilian folk medicine" is usually described as a rich mixture of African, European, and Indigenous medical traditions...
  9. Yoshimatsu K, Shimomura K, Yamazaki M, Saito K, Kiuchi F. Transformation of ipecac (Cephaelis ipecacuanha) with Agrobacterium rhizogenes. Planta Med. 2003;69:1018-23 pubmed
    Transformed root cultures of ipecac (Cephaelis ipecacuanha A...

More Information

Publications11

  1. Rossi A, de Oliveira L, Venturini B, dos Santos Silva R. Genetic diversity and geographic differentiation of disjunct Atlantic and Amazonian populations of Psychotria ipecacuanha (Rubiaceae). Genetica. 2009;136:57-67 pubmed publisher
    ..Conservation implications are discussed...
  2. Nomura T, Quesada A, Kutchan T. The new beta-D-glucosidase in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha. J Biol Chem. 2008;283:34650-9 pubmed publisher
    ..These facts have significant implications for distinct physiological roles of 1 alpha(S)- and 1 beta(R)-epimers and for the involvement of IpeGlu1 in the metabolic fate of both of them...