strychnos

Summary

Summary: A plant genus of the family LOGANIACEAE (classified by some botanists as Strychnaceae).

Top Publications

  1. Itoh A, Tanaka Y, Nagakura N, Akita T, Nishi T, Tanahashi T. Phenolic and iridoid glycosides from Strychnos axillaris. Phytochemistry. 2008;69:1208-14 pubmed publisher
    ..Their structures were determined by application of spectroscopic (NMR, MS) and chemical methodologies...
  2. Belem Pinheiro M, Couceiro P, Da Rocha A, Monte F, Villar J. A new strychnobrasiline base of Strychnos mattogrossensis. Nat Prod Lett. 2002;16:229-33 pubmed
    ..derivative, 12-hydroxy-10,11-dimethoxystrychnobrasiline 1, has been isolated from the stem barks of Strychnos mattogrossensis...
  3. Dounay A, Humphreys P, Overman L, Wrobleski A. Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization. J Am Chem Soc. 2008;130:5368-77 pubmed publisher
    A 1,2,3,4-tetrahydro-9a,4a-(iminoethano)-9H-carbazole (4) is a central structural feature of the Strychnos alkaloid minfiensine (1) and akuammiline alkaloids such as vincorine (5) and echitamine (6)...
  4. Frederich M, Choi Y, Angenot L, Harnischfeger G, Lefeber A, Verpoorte R. Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by 1H nuclear magnetic resonance spectrometry and multivariate analysis techniques. Phytochemistry. 2004;65:1993-2001 pubmed
    ..resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species: Strychnos nux-vomica (seeds, stem bark, root bark), Strychnos ignatii (seeds), and Strychnos icaja (..
  5. Itoh A, Oya N, Kawaguchi E, Nishio S, Tanaka Y, Kawachi E, et al. Secoiridoid glucosides from Strychnos spinosa. J Nat Prod. 2005;68:1434-6 pubmed
    ..glucosides, stryspinoside (1) and strychosides A (2) and B (3), were isolated, together with 23 known compounds, from the dried branches of Strychnos spinosa. The structures of the new compounds were determined by spectroscopic means.
  6. Hoet S, Pieters L, Muccioli G, Habib Jiwan J, Opperdoes F, Quetin Leclercq J. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J Nat Prod. 2007;70:1360-3 pubmed
    Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time...
  7. Philippe G, De Mol P, Zèches Hanrot M, Nuzillard J, Tits M, Angenot L, et al. Indolomonoterpenic alkaloids from Strychnos icaja roots. Phytochemistry. 2003;62:623-9 pubmed
    In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, ..
  8. Philippe G, Angenot L, Tits M, Frederich M. About the toxicity of some Strychnos species and their alkaloids. Toxicon. 2004;44:405-16 pubmed
    ..Owing to their poisonous properties, some species of Strychnos genus have been employed mainly in hunting and fishing, as an adjunct to weapons used not only in the search of ..
  9. Thongphasuk P, Suttisri R, Bavovada R, Verpoorte R. Antioxidant lignan glucosides from Strychnos vanprukii. Fitoterapia. 2004;75:623-8 pubmed
    From the stem of Strychnos vanprukii, two new lignan glucosides, vanprukoside (1) and strychnoside (2), were isolated together with the known lignan glucoside, (+)-lyoniresinol-3 alpha-O-beta-glucopyranoside (3)...

More Information

Publications102 found, 100 shown here

  1. Philippe G, Angenot L, De Mol P, Goffin E, Hayette M, Tits M, et al. In vitro screening of some Strychnos species for antiplasmodial activity. J Ethnopharmacol. 2005;97:535-9 pubmed
    The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum...
  2. Santos F, Colus I, Silva M, Vilegas W, Varanda E. Assessment of DNA damage by extracts and fractions of Strychnos pseudoquina, a Brazilian medicinal plant with antiulcerogenic activity. Food Chem Toxicol. 2006;44:1585-9 pubmed
    b>Strychnos pseudoquina St. Hil. is a native plant of the Brazilian Savannah, used in popular medicine to treat a number of conditions...
  3. Sanmugapriya E, Venkataraman S. Antiulcerogenic potential of Strychnos potatorum Linn seeds on aspirin plus pyloric ligation-induced ulcers in experimental rats. Phytomedicine. 2007;14:360-5 pubmed
    b>Strychnos potatorum (Fam: Loganiaceae) Linn seeds are useful in the treatment of gastropathy in Indian traditional system of medicine. The present study describes the antiulcerogenic potential of S...
  4. Dhalwal K, Shinde V, Namdeo A, Mahadik K, Kadam S. Development and validation of a TLC-densitometric method for the simultaneous quantitation of strychnine and brucine from Strychnos spp. and its formulations. J Chromatogr Sci. 2007;45:706-9 pubmed
    ..These two marker compounds are quantitated in the seeds of Strychnos nux-vomica, Strychnos ignatii, and its formulations...
  5. Honorio França A, Marins C, Boldrini F, França E. Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL). Acta Cir Bras. 2008;23:504-10 pubmed
    Evaluation the hypoglycemic and healing effects of the Strychnos pseudoquina.
  6. Yang G, Tu X, Liu L, Pan Y. Two new bisindole alkaloids from the seeds of Strychnos nux-vomica. Fitoterapia. 2010;81:932-6 pubmed publisher
    The reinvestigation of Strychnos nux-vomica resulted in the isolation of two colorless monoquaternary bisindole alkaloids from the seeds...
  7. Frederich M, Jacquier M, Thépenier P, De Mol P, Tits M, Philippe G, et al. Antiplasmodial activity of alkaloids from various strychnos species. J Nat Prod. 2002;65:1381-6 pubmed
    The in vitro antiplasmodial activities of 69 alkaloids from various Strychnos species were evaluated against chloroquine-resistant and chloroquine-sensitive lines of Plasmodium falciparum...
  8. Thongphasuk P, Suttisri R, Bavovada R, Verpoorte R. Alkaloids and a pimarane diterpenoid from Strychnos vanprukii. Phytochemistry. 2003;64:897-901 pubmed
    From the stem of Strychnos vanprukii, a gluco-indole alkaloid, 3,4-dehydropalicoside, and a pimarane diterpenoid, 7 beta-hydroxypimara-8,15-dien-14-one, were isolated together with four known alkaloids: palicoside, 3,4,5,6-..
  9. Frederich M, Cristino A, Choi Y, Verpoorte R, Tits M, Angenot L, et al. Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves. Planta Med. 2004;70:72-6 pubmed
    A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR)...
  10. Frederich M, Tits M, Goffin E, Philippe G, Grellier P, De Mol P, et al. In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis. Planta Med. 2004;70:520-5 pubmed
    Isostrychnopentamine (ISP) is an asymmetric indolomonoterpenic alkaloid isolated from the leaves of Strychnos usambarensis...
  11. Sanmugapriya E, Venkataraman S. Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats. J Ethnopharmacol. 2006;105:154-60 pubmed
    b>Strychnos potatorum Linn...
  12. Hoet S, Stévigny C, Herent M, Quetin Leclercq J. Antitrypanosomal compounds from the leaf essential oil of Strychnos spinosa. Planta Med. 2006;72:480-2 pubmed
    The composition of the essential oil obtained by hydrodistillation of the leaves of Strychnos spinosa (Loganiaceae) was analysed by GC-FID and GC-MS...
  13. Ekambaram S, Perumal S, Subramanian V. Evaluation of antiarthritic activity of Strychnos potatorum Linn seeds in Freund's adjuvant induced arthritic rat model. BMC Complement Altern Med. 2010;10:56 pubmed publisher
    b>Strychnos potatorum Linn (Loganiaceae) is a moderate sized tree found in southern and central parts of India, Sri Lanka and Burma...
  14. Cao M, Muganga R, Tits M, Angenot L, Frederich M. 17-O-acetyl,10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves. Planta Med. 2011;77:2050-3 pubmed publisher
    In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: ..
  15. Savalia R, Chatterjee S. Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor. Biosens Bioelectron. 2017;98:371-377 pubmed publisher
    ..The analytical utility was further assessed by the selective determination of brucine in Strychnos nux-vomica seeds exhibiting considerable potential as a diagnostic tool.
  16. Yazbek P, Tezoto J, Cassas F, Rodrigues E. Plants used during maternity, menstrual cycle and other women's health conditions among Brazilian cultures. J Ethnopharmacol. 2016;179:310-31 pubmed publisher
    ..The most cited family was Fabaceae (13.5%), and the species were Ruta graveolens L. (1.76%) and Strychnos pseudoquina A. St.-Hil (1.76%)...
  17. Gan C, Etoh T, Hayashi M, Komiyama K, Kam T. Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis. J Nat Prod. 2010;73:1107-11 pubmed publisher
    Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii...
  18. Yu Q, Guo P, Jian J, Chen Y, Xu J. Nine-step total synthesis of (-)-strychnofoline. Chem Commun (Camb). 2018;54:1125-1128 pubmed publisher
    Strychnofoline is a Strychnos alkaloid that has unique spirooxindole architecture and possesses important anticancer activity...
  19. Wang B, Dai Z, Liu L, Wei X, Zhu P, Yu H, et al. Indole Glycosides from Aqueous Fraction of Strychnos nitida. Nat Prod Bioprospect. 2016;6:285-290 pubmed
    ..3), together with four known analogues were isolated from aqueous fraction of Strychnos nitida. Their structures were elucidated on the basis of extensive analysis of spectroscopic data...
  20. Sarandy M, Novaes R, Xavier A, Vital C, Leite J, Melo F, et al. Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes. Biomed Res Int. 2017;2017:9538351 pubmed publisher
    The effect of topical application of ointment based on Strychnos pseudoquina hydroethanolic extract in the cutaneous wounds healing in diabetic rats was evaluated. Samples of S...
  21. Kokkonda P, Brown K, Seguin T, Wheeler S, Vaddypally S, Zdilla M, et al. Biomimetic Total Syntheses of (-)-Leucoridines A and C through the Dimerization of (-)-Dihydrovalparicine. Angew Chem Int Ed Engl. 2015;54:12632-5 pubmed publisher
    Concise biomimetic syntheses of the Strychnos-Strychnos-type bis-indole alkaloids (-)-leucoridine A (1) and C (2) were accomplished through the biomimetic dimerization of (-)-dihydrovalparicine (3)...
  22. Maertens G, Canesi S. Synthesis of the Strychnos Alkaloid (-)-Strychnopivotine and Confirmation of its Absolute Configuration. Chemistry. 2016;22:7090-3 pubmed publisher
    ..The absolute configuration of the natural compound, which, to date, has been uncertain, was confirmed by using circular dichroism (CD) spectroscopy and X-ray analyses. ..
  23. Randrianarivony T, Ramarosandratana A, Andriamihajarivo T, Rakotoarivony F, Jeannoda V, Randrianasolo A, et al. The most used medicinal plants by communities in Mahaboboka, Amboronabo, Mikoboka, Southwestern Madagascar. J Ethnobiol Ethnomed. 2017;13:19 pubmed publisher
    ..48), Henonia scoparia (UV?=?0.43) are mostly used species. Leonotis nepetifolia (FL?=?96%) and Strychnos henningsii (FL?=?92%) are plant species claimed by high percentage of informants to treat the Digestive System ..
  24. Wu P, Liang Q, Feng P, Li C, Yang C, Liang H, et al. A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities. Int J Mol Sci. 2017;18: pubmed publisher
    The seeds of Strychnosnux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities...
  25. Giovannini P, Howes M. Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence. J Ethnopharmacol. 2017;199:240-256 pubmed publisher
    ..Piper amalago L., Aristolochia trilobata L., Sansevieria hyacinthoides (L.) Druce, Strychnos panamensis Seem., Dorstenia contrajerva L., Scoparia dulcis L., Hamelia patens Jacq., and Simaba cedron Planch...
  26. Madzimure J, Nyahangare E, Hamudikuwanda H, Hove T, Belmain S, Stevenson P, et al. Efficacy of Strychnos spinosa (Lam.) and Solanum incanum L. aqueous fruit extracts against cattle ticks. Trop Anim Health Prod. 2013;45:1341-7 pubmed publisher
    The efficacy of Solanum incanum and Strychnos spinosa aqueous fruit extracts was evaluated against cattle ticks in on-station experiments and laboratory tick bioassays...
  27. Li W, Tang G, Chen L, Tang Y, Xu Y, Liu B, et al. New pyridocarbazole alkaloids from Strychnos nitida. Nat Prod Res. 2017;:1-5 pubmed publisher
    Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6)...
  28. Zhao S, Teijaro C, Chen H, Sirasani G, Vaddypally S, Zdilla M, et al. Concise Syntheses of bis-Strychnos Alkaloids (-)-Sungucine, (-)-Isosungucine, and (-)-Strychnogucine B from (-)-Strychnine. Chemistry. 2016;22:11593-6 pubmed publisher
    The first chemical syntheses of complex, bis-Strychnos alkaloids (-)-sungucine (1), (-)-isosungucine (2), and (-)-strychnogucine B (3) from (-)-strychnine (4) is reported...
  29. Heureux N, Wouters J, Marko I. Sequential acid/base-catalyzed polycyclization of tryptamine derivatives. A rapid access to Büchi's ketone. Org Lett. 2005;7:5245-8 pubmed
    ..methodology that allows the rapid construction of the tetracyclic core of the Aspidosperma and Strychnos alkaloid families is described...
  30. Pontes A. Seed cleaning of Strychnos ramentifera (Loganiaceae) by ants in Maracá Island, Brazilian Amazonia. Braz J Biol. 2005;65:551-3 pubmed
  31. Nistor I, Cao M, Debrus B, Lebrun P, Lecomte F, Rozet E, et al. Application of a new optimization strategy for the separation of tertiary alkaloids extracted from Strychnos usambarensis leaves. J Pharm Biomed Anal. 2011;56:30-7 pubmed publisher
    The HPLC separation of six alkaloids extracted from Strychnos usambarensis leaves has been developed and optimized by means of a powerful methodology for modelling chromatographic responses, based on three steps, i.e...
  32. Philippe G, Nguyen L, Angenot L, Frederich M, Moonen G, Tits M, et al. Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor. Eur J Pharmacol. 2006;530:15-22 pubmed
    b>Strychnos icaja Baill. (Loganiaceae) is a liana found in Central Africa known to be an arrow and ordeal poison but also used by traditional medicine to treat malaria...
  33. Pereira J, Barlier M, Guillou C. Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization. Org Lett. 2007;9:3101-3 pubmed
    ..From these compounds, tetracyclic ketones can be synthesized to provide useful intermediates for the synthesis of indole alkaloids. ..
  34. Marzotto M, Conforti A, Magnani P, Zanolin M, Bellavite P. Effects of Ignatia amara in mouse behavioural models. Homeopathy. 2012;101:57-67 pubmed publisher
    Ignatia amara (Ignatia), a remedy made from the Strychnos ignatii seeds, is used for anxiety-related symptoms, but consistent evidence of its activity in reproducible experimental models is lacking...
  35. Rakotomalala E, Rakotondraparany F, Perofsky A, Lewis R. Characterization of the Tree Holes Used by Lepilemur ruficaudatus in the Dry, Deciduous Forest of Kirindy Mitea National Park. Folia Primatol (Basel). 2017;88:28-41 pubmed publisher
    ..ruficaudatus sleeping sites. Intact and alive trees, particularly Strychnos madagascariensis, were preferred by L. ruficaudatus...
  36. Wang C, Li C, Zang X, Han D, Liu Z, Wang Z. Hollow fiber-based liquid-phase microextraction combined with on-line sweeping for trace analysis of Strychnos alkaloids in urine by micellar electrokinetic chromatography. J Chromatogr A. 2007;1143:270-5 pubmed
    A new method for the enrichment of Strychnos alkaloids in biological samples via liquid-phase microextraction (LPME) based on porous polypropylene hollow fibers combined with on-line sweeping in micellar electrokinetic chromatography (..
  37. Lee S, Kwon J, Choi Y, Eom H, Chi G. Induction of G2/M arrest and apoptosis by water extract of Strychni Semen in human gastric carcinoma AGS cells. Phytother Res. 2008;22:752-8 pubmed publisher
    The seed of Strychnos nux-vomica (Loganiaceae) has been used in traditional Oriental medicine as a folk remedy for the treatment of cancer...
  38. Chen J, Luo Y, Hwang T, Sung P, Wang T, Chen I. A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis. Chem Biodivers. 2008;5:1345-52 pubmed publisher
    A new indole alkaloid, 11,12-dimethoxyhenningsamine, was isolated from the roots of Strychnos cathayensis, together with 19 known compounds...
  39. Wins P, Margineanu I, Penelle J, Angenot L, Grisar T, Bettendorff L. Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:253-9 pubmed
    Several mono- and bisindole quaternary alkaloids isolated from the stem bark of Strychnos guianensis have recently been shown to be effective blockers of neuromuscular transmission in mice...
  40. Nguyen Q, Nguyen V, Santarsiero B, Mesecar A, Nguyen M, Soejarto D, et al. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. J Nat Prod. 2004;67:994-8 pubmed
    ..3beta-O-trans-coumaroylbetulinic acid (3) and ursolic acid (6) were isolated from the leaves and twigs of Strychnos vanprukiiCraib...
  41. Wang X, He C, Chen Y, Chen J, Cai B. [Determination and comparison of plasma protein binding rate of alkaloids from seed of Strychnou nux-vomica]. Zhongguo Zhong Yao Za Zhi. 2011;36:185-8 pubmed
    ..In comparison with the single component of the same concentration, the protein binding rate of brucine in total alkaloids shows little difference, while there seems to be an obvious decrease for strychnine. ..
  42. Chen J, Xiao H, Hu R, Hu W, Chen Z, Cai H, et al. Pharmacokinetics of brucine after intravenous and oral administration to rats. Fitoterapia. 2011;82:1302-8 pubmed publisher
    ..The results of dose-dependent pharmacokinetic behavior under different administration routes may account for the significantly different toxicities of brucine between intravenous and oral administration. ..
  43. Reekie T, Banwell M, Willis A. A Raney-cobalt-mediated tandem reductive cyclization route to the 1,5-methanoazocino[4,3-b]indole framework of the uleine and Strychnos alkaloids. J Org Chem. 2012;77:10773-81 pubmed publisher
    ..These products embody the ABCD-ring system associated with the title alkaloids, and compound 11 can be converted, over four steps and in 33% yield, into congener 24 incorporating the ABCDE-ring system of the Strychnos alkaloids.
  44. Gaisberger H, Kindt R, Loo J, Schmidt M, Bognounou F, Da S, et al. Spatially explicit multi-threat assessment of food tree species in Burkina Faso: A fine-scale approach. PLoS ONE. 2017;12:e0184457 pubmed publisher
    ..costatum, Boscia senegalensis, Detarium microcarpum, Lannea microcarpa, Parkia biglobosa, Sclerocarya birrea, Strychnos spinosa, Tamarindus indica, Vitellaria paradoxa, Ximenia americana, Ziziphus mauritiana) and six key threats to ..
  45. Maddisetty P, Doss V, S M, V S, T M. HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves. Pak J Pharm Sci. 2017;30:2369-2373 pubmed
    ..Twenty one medicinal bio active compounds were identified from the Strychnos nux-vomica leaf ethanolic extract. Strychnine is showing 28...
  46. Frederich M, Bentires Alj M, Tits M, Angenot L, Greimers R, Gielen J, et al. Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. J Pharmacol Exp Ther. 2003;304:1103-10 pubmed
    Isostrychnopentamine (ISP) is an indolomonoterpenic alkaloid that is present in the leaves of Strychnos usambarensis, a well known African shrub or little tree...
  47. Wright C. Recent developments in research on terrestrial plants used for the treatment of malaria. Nat Prod Rep. 2010;27:961-8 pubmed publisher
  48. Mitra S, Shukla V, Acharya R. Effect of purificatory measures through cow's urine and milk on strychnine and brucine content of Kupeelu (Strychnos nuxvomica Linn.) seeds. Afr J Tradit Complement Altern Med. 2012;9:105-11 pubmed
    b>Strychnos nux vomica Linn.(Loganaceae) commonly known as Nux vomica (Kupeelu), is a poisonous plant and its seeds are used widely in Ayurvedic system of medicine since time immemorial...
  49. Sirasani G, Andrade R. Sequential one-pot cyclizations: concise access to the ABCE tetracyclic framework of strychnos alkaloids. Org Lett. 2009;11:2085-8 pubmed publisher
    A sequential one-pot biscyclization route to the ABCE tetracyclic framework of Strychnos alkaloids has been developed...
  50. Tatsis E, Carqueijeiro I, Dugé de Bernonville T, Franke J, Dang T, Oudin A, et al. A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate. Nat Commun. 2017;8:316 pubmed publisher
    ..The tetrahydro-?-carboline of strictosidine aglycone is converted into akuammicine, a Strychnos alkaloid, an elusive biosynthetic transformation that has been investigated for decades...
  51. Wang Y, Lin J, Wang X, Wang G, Zhang X, Yao B, et al. Brønsted Acid-Catalyzed Tandem Cyclizations of Tryptamine-Ynamides Yielding 1H-Pyrrolo[2,3-d]carbazole Derivatives. Chemistry. 2017;: pubmed publisher
    ..The 1H-pyrrolo[2,3-d]carbazole was a core scaffold of a series of monoterpene indole alkaloids such as Kopsia, Strychnos and Aspidosperma...
  52. Lynch S, Bur S, Padwa A. Intramolecular amidofuran cycloadditions across an indole pi-bond: an efficient approach to the aspidosperma and strychnos ABCE core. Org Lett. 2002;4:4643-5 pubmed
    ..moiety tethered onto an indole component was examined as a strategy for the synthesis of Aspidosperma and Strychnos alkaloids. Furanyl carbamate 13 was acylated using the mixed anhydride 16 to provide amidofuran 12 in 68% yield...
  53. Dausmann K, Glos J, Linsenmair K, Ganzhorn J. Improved recruitment of a lemur-dispersed tree in Malagasy dry forests after the demise of vertebrates in forest fragments. Oecologia. 2008;157:307-16 pubmed publisher
    ..where the usual seed dispersers and vertebrate seed predators were absent, using a lemur-dispersed tree species (Strychnos madagascariensis; Loganiaceae) as an example...
  54. Yan J, Liu Z, Yan C, Xing J, Liu S. Analysis of strychnos alkaloids using electrospray ionization Fourier transform ion cyclotron resonance multi-stage tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20:1335-44 pubmed
    The fragmentations of four strychnos alkaloids have been investigated by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) in the positive ion mode...
  55. Boonsombat J, Zhang H, Chughtai M, Hartung J, Padwa A. A general synthetic entry to the pentacyclic strychnos alkaloid family, using a [4 + 2]-cycloaddition/rearrangement cascade sequence. J Org Chem. 2008;73:3539-50 pubmed publisher
    ..an indolyl-substituted amidofuran that delivers an aza-tetracyclic substructure containing the ABCE-rings of the Strychnos alkaloid family...
  56. Han Q, Li S, Qiao C, Song J, Cai Z, Pui Hay But P, et al. A simple method to identify the unprocessed Strychnos seeds used in herbal medicinal products. Planta Med. 2008;74:458-63 pubmed publisher
    The seeds of Strychnos nux-vomica are popularly used in the treatment of arthritis. Being extremely toxic, the raw seeds are forbidden and must be processed before clinical use...
  57. Bonamin F, Moraes T, Kushima H, Silva M, Rozza A, Pellizzon C, et al. Can a Strychnos species be used as antiulcer agent? Ulcer healing action from alkaloid fraction of Strychnos pseudoquina St. Hil. (Loganiaceae). J Ethnopharmacol. 2011;138:47-52 pubmed publisher
    b>Strychnos pseudoquina St. Hil. (Loganiaceae) is one Brazilian native medicinal species described in the first edition of the Brazilian Official Pharmacopoeia in 1929...
  58. Liu P, Wang J, Zhang J, Qiu F. A concise total synthesis of (±)-minfiensine. Org Lett. 2011;13:6426-8 pubmed publisher
    ..The synthesis features a Fischer indole synthesis, a Heck alkylation of an intermediate ketone enolate, conversion of a ketone carbonyl into an epoxide, and transformation of the latter into an allylic alcohol...
  59. Zlotos D. iso-caracurine V, a novel unexpected decomposition product of caracurine V. J Nat Prod. 2003;66:119-20 pubmed
    The structure of iso-caracurine V (3), an unexpected decomposition product of the Strychnos alkaloid caracurine V (1), was determined by NMR spectroscopy...
  60. Frederich M, Bentires Ali M, Tits M, Angenot L, Heinen E, De Pauw Gillet M. Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:260-5 pubmed
    ..alkaloids characterized by a 5'-23 link between the two parts of the compounds, which are till now specific to Strychnos icaja...
  61. Babu R, Chaudhuri M. Home water treatment by direct filtration with natural coagulant. J Water Health. 2005;3:27-30 pubmed
    Seeds of the plant species Strychnos potatorum and Moringa oleifera contain natural polyelectrolytes which can be used as coagulants to clarify turbid waters...
  62. Philippe G, De Mol P, Angenot L, Tits M, Frederich M. In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja. Planta Med. 2007;73:478-9 pubmed
    Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined...
  63. Martin D, Vanderwal C. Efficient access to the core of the Strychnos, Aspidosperma and Iboga alkaloids. A short synthesis of norfluorocurarine. J Am Chem Soc. 2009;131:3472-3 pubmed publisher
    ..tryptamine-derived Zincke aldehydes forms the basis for a three-step route to the tetracyclic ABCE core of many Strychnos, Aspidosperma, and Iboga alkaloids...
  64. Sunghwa F, Koketsu M. Phenolic and bis-iridoid glycosides from Strychnos cocculoides. Nat Prod Res. 2009;23:1408-15 pubmed publisher
    A new bis-iridoid glucoside, cocculoside (1), has been isolated, together with five known compounds from Strychnos cocculoides (Loganiaceae), collected in Tanzania...
  65. Koolen H, Soares E, Silva F, Souza A, Medeiros L, Filho E, et al. An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera. Nat Prod Res. 2012;26:2013-9 pubmed
    From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf...
  66. Ahn K, Yi K, Park H, Shin J, Hur J, Kim S, et al. Anti-proliferative effect of Klimaktoplan® on human breast cancer cells. Arch Gynecol Obstet. 2013;288:833-8 pubmed publisher
    ..The study investigated the safety of Klimaktoplan® through its effect on the proliferation of breast cancer (MCF-7) and non-malignant mammary epithelial cells (MCF-10A)...
  67. Feng T, Li X, Zhang B, Li Y, Cai X, Liu Y, et al. Gardovatine, a novel Strychnos-Strychnos bisindole alkaloid with cytotoxicity from Gardneria oveta. Bioorg Med Chem Lett. 2013;23:5563-5 pubmed publisher
    Gardovatine (1), the first Strychnos-Strychnos alkaloid with a C3/C7 cleaved backbone, was isolated from twigs and leaves of Gardneria ovate, together with an analogue divarine (2)...
  68. Tchinda A, Jansen O, Nyemb J, Tits M, Dive G, Angenot L, et al. Strychnobaillonine, an unsymmetrical bisindole alkaloid with an unprecedented skeleton from Strychnos icaja roots. J Nat Prod. 2014;77:1078-82 pubmed publisher
    A reinvestigation of the roots of Strychnos icaja resulted in the isolation of a new bisindole alkaloid named strychnobaillonine (1) with original C-17-N-1' and C-23-C-17' junctions, in addition to sungucine, bisnordihydrotoxiferine, and ..
  69. Fentahun S, Makonnen E, Awas T, Giday M. In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice. BMC Complement Altern Med. 2017;17:13 pubmed publisher
    ..The present study aimed to evaluate antiplasmodial activity and acute toxicity of the plant Strychnos mitis in Plasmodium berghei infected mice...
  70. Chan T. Herbal medicine causing likely strychnine poisoning. Hum Exp Toxicol. 2002;21:467-8 pubmed
    Maqianzi' (the dried ripe seed of Strychnos nux-vomica L.) contains 1.0-1.4% each of strychnine and brucine...
  71. Lerchner A, Carreira E. First total synthesis of (+/-)-strychnofoline via a highly selective ring-expansion reaction. J Am Chem Soc. 2002;124:14826-7 pubmed
    ..The ability to conduct annulation reactions of spirocyclopropyloxindoles with functionalized cyclic imines provides new avenues for the preparation of this important class of biologically active structures...
  72. Sitrit Y, Loison S, Ninio R, Dishon E, Bar E, Lewinsohn E, et al. Characterization of monkey orange (Strychnos spinosa Lam.), a potential new crop for arid regions. J Agric Food Chem. 2003;51:6256-60 pubmed
    The green monkey orange (Strychnos spinosa Lam., Loganiaceae), a tree indigenous to tropical and subtropical Africa, produces juicy, sweet-sour, yellow fruits containing numerous hard brown seeds...
  73. da Silva M, Rafacho B, Hiruma Lima C, da Rocha L, dos Santos L, Sannomiya M, et al. Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice. Chem Pharm Bull (Tokyo). 2005;53:881-5 pubmed
    b>Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice...
  74. Jayaram K, Murthy I, Lalhruaitluanga H, Prasad M. Biosorption of lead from aqueous solution by seed powder of Strychnos potatorum L. Colloids Surf B Biointerfaces. 2009;71:248-54 pubmed publisher
    In the present study, Pb(II) removal efficiency of Strychnos potatorum seed powder (SPSP) from aqueous solution has been investigated...
  75. Saidou Balde E, Megalizzi V, Cao M, Angenot L, Kiss R, Van Damme M, et al. Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells. Int J Oncol. 2010;36:961-5 pubmed
    Isostrychnopentamine (ISP) is an indolomonoter-penic alkaloid that is present in the leaves of Strychnos usambarensis, an East African small tree...
  76. Shi C, Chien C, Ojima I. Synthesis of chiral biphenol-based diphosphonite ligands and their application in palladium-catalyzed intermolecular asymmetric allylic amination reactions. Chem Asian J. 2011;6:674-80 pubmed publisher
    ..ligands have exhibited excellent efficiency in a palladium-catalyzed intermolecular allylic amination reaction, which provides a key intermediate for the total synthesis of Strychnos indole alkaloids with enantiopurities of up to 96% ee.
  77. Kariuki A, Njoroge G. Ethnobotanical and antimicrobial studies of some plants used in Kibwezi (Kenya) for management of lower respiratory tract infections. Afr J Tradit Complement Altern Med. 2011;8:144-9 pubmed
    ..Water and methanolic extracts of the three most popular plants, Acacia nilotica, Strychnos heninngsii and Microglossa densiflora were tested against three test organism: Staphylococcus aureus, ..
  78. Biswas A, Chatterjee S, Chowdhury R, Sen S, SARKAR D, Chatterjee M, et al. Antidiabetic effect of seeds of Strychnos potatorum Linn. in a streptozotocin-induced model of diabetes. Acta Pol Pharm. 2012;69:939-43 pubmed
    The antidiabetic effect of seeds of Strychnos potatorum Linn. was evaluated in a model of diabetes mellitus using streptozotocin (40 mg/kg b.w., i.p.)...
  79. Wang Q, Liu L, Huang G. [Study of toxicology of strychnos]. Fa Yi Xue Za Zhi. 2004;20:183-4 pubmed
    Because of its officinal value, strychnos is widely used by clinic and individual. Since toxic dose and therapeutic dose are very close, strychnos poisoning cases are frequently reported...
  80. Bennasar M, Roca T, García Díaz D. A new acyl radical-based route to the 1,5-methanoazocino[4,3-b]indole framework of uleine and Strychnos alkaloids. J Org Chem. 2008;73:9033-9 pubmed publisher
    ..which constitute the tetracyclic framework of uleine alkaloids as well as the ABDE substructure of the Strychnos alkaloid family, have been synthesized by novel 6-exo and 6-endo cyclizations of selenoester-derived 2-..
  81. Sunghwa F, Sakurai H, Saiki I, Koketsu M. Iodine-catalyzed etherification of morroniside. Chem Pharm Bull (Tokyo). 2009;57:112-5 pubmed
    ..Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 microM...
  82. Zhang M, Huang X, Shen L, Qin Y. Total synthesis of the akuammiline alkaloid (+/-)-vincorine. J Am Chem Soc. 2009;131:6013-20 pubmed publisher
    ..1,2-disubstituted 1,2,3,4-tetrahydro-4a,9a-iminoethanocarbazole (1), a distinctive feature of akuammiline and strychnos alkaloids, was developed via a three-step one-pot cascade reaction consisting of copper-catalyzed intramolecular ..
  83. Sirasani G, Andrade R. Total synthesis of (-)-leuconicine A and B. Org Lett. 2011;13:4736-7 pubmed publisher
    Concise asymmetric total syntheses of Strychnos alkaloids (-)-leuconicine A (14 steps, 9% overall yield) and B (13 steps, 10% overall yield) have been accomplished...
  84. Tchinda A, Ngono A, Tamze V, Jonville M, Cao M, Angenot L, et al. Antiplasmodial alkaloids from the stem bark of Strychnos malacoclados. Planta Med. 2012;78:377-82 pubmed publisher
    From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), ..
  85. Edwankar R, Edwankar C, Namjoshi O, Deschamps J, Cook J. Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids. J Nat Prod. 2012;75:181-8 pubmed publisher
    ..of an efficient diastereoselective method that permits rapid construction of the tetracyclic core 17 of the Strychnos-Aspidosperma alkaloids is described...
  86. Sun M, Guo Y, Dai B, Wang C, He L. High-expression EGFR/cell membrane chromatography-online-high-performance liquid chromatography/mass spectrometry: rapid screening of EGFR antagonists from Semen Strychni. Rapid Commun Mass Spectrom. 2012;26:2027-32 pubmed publisher
    ..In order to improve this situation, we established an online analytical method for screening, separation and identification EGFR antagonists from traditional Chinese medicines, which is described in this study...
  87. Tian J, Peng C, Xu L, Tian Y, Zhang Z. In vitro metabolism study of Strychnos alkaloids using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. Biomed Chromatogr. 2013;27:775-83 pubmed publisher
    In this report, the in vitro metabolism of Strychnos alkaloids was investigated using liquid chromatography/high-resolution mass spectrometry for the first time...
  88. Dounay A, Overman L, Wrobleski A. Sequential catalytic asymmetric Heck-iminium ion cyclization: enantioselective total synthesis of the Strychnos alkaloid minfiensine. J Am Chem Soc. 2005;127:10186-7 pubmed
    ..In eight additional steps, this latter intermediate is transformed to (+)-minfiensine (4)...
  89. Aponte J, Vaisberg A, Rojas R, Caviedes L, Lewis W, Lamas G, et al. Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants. J Nat Prod. 2008;71:102-5 pubmed publisher
    ..bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their ..
  90. Gong Z, Sun L, Cao X, Li S, Zhu X, Gao T. [Strychnos alkaloids inhibit the proliferation of adult rat neuroprogenitor cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28:2121-5 pubmed
    To study the effects of strychnos alkaloids on the proliferation of adult rat neuroprogenitor cells.
  91. Wang W, Chen J, Cai B, Fang Y. [Influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients]. Zhong Yao Cai. 2008;31:1410-2 pubmed
    ..To study the influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients...
  92. Li J, Wang D, Cai B. [A comparative study on HPLC fingerprint of Semen Strychni and the processed]. Zhong Yao Cai. 2009;32:1816-9 pubmed
    ..To establish the fingerprint of Semen Strychni and the processed by HPLC...