swertia

Summary

Summary: A plant genus of the family GENTIANACEAE. It is a source of swertiapuniside and IRIDOID GLYCOSIDES.

Top Publications

  1. Bhat G, Surolia N. In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. Am J Trop Med Hyg. 2001;65:304-8 pubmed
    ..Aqueous and organic solvent extracts obtained from specific parts of the plants Swertia chirata, Carica papaya, and Citrus sinensis were tested on malaria strain Plasmodium falciparum FCK 2 in vitro...
  2. Yang H, Ding C, Duan Y, Liu J. Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. J Ethnopharmacol. 2005;98:31-5 pubmed
    ..1,8-dihydroxy-3,7-dimethoxyxanthone and 1,8-dihydroxy-3,5-dimethoxyxanthone) of "ZangYinChen" (Swertia mussotii, a herb used in Tibetan folk medicine) were determined and compared in plants collected from naturally ..
  3. Rana V, Rawat M. A new xanthone glycoside and antioxidant constituents from the rhizomes of Swertia speciosa. Chem Biodivers. 2005;2:1310-5 pubmed
    From the rhizomes of Swertia speciosa, a traditional medicinal plant from the Himalayan region of Uttaranchal (North India), a new constituent, 6-hydroxy-3,5-dimethoxy-1-[(6-O-beta-D-xylopyranosyl-beta-D-glucopyranosyl)oxy]-9H-xanthen-9-..
  4. Brahmachari G, Mondal S, Gangopadhyay A, Gorai D, Mukhopadhyay B, Saha S, et al. Swertia (Gentianaceae): chemical and pharmacological aspects. Chem Biodivers. 2004;1:1627-51 pubmed
    A compilation of the constituents isolated from Swertia species covering the literature up to December 2003 is presented...
  5. Zhang X, Huang F, Chen J, Liu Y. [Determination of three glycosides from herbs of Swertia punicea by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2007;32:1184-6 pubmed
    To develop a RP-HPLC method for determination of three glycosides in Swertia punicea. Chromatographic column: Alltimal C18 (4.6 mm x 250 mm, 5 microm). Mobile phase: methanol-water (including 0.05% H3PO4), and gradient elution...
  6. Negi J, Singh P, Pant G, Rawat M. RP-HPLC analysis and antidiabetic activity of Swertia paniculata. Nat Prod Commun. 2010;5:907-10 pubmed
    ..SR2) have been qualitatively and quantitatively determined in leaves and rhizomes of Swertia paniculata...
  7. Kumar I, Paul B, Asthana R, Saxena A, Mehrotra S, Rajan G. Swertia chirayita mediated modulation of interleukin-1beta, interleukin-6, interleukin-10, interferon-gamma, and tumor necrosis factor-alpha in arthritic mice. Immunopharmacol Immunotoxicol. 2003;25:573-83 pubmed
    The effect of aqueous extract of Swertia chirayita stem on the pro- and anti-inflammatory cytokines balance in primary joint synovium of adjuvant-induced arthritic mice has been studied...
  8. Wang J, Liu Y, Cai Y, Zhang F, Xia G, Xiang F. Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch. Biosci Biotechnol Biochem. 2010;74:1583-90 pubmed
    b>Swertia mussotii Franch has anti-hepatitis activity and contains a high level of iridoid monoterpenoids...
  9. Nagalekshmi R, Menon A, Chandrasekharan D, Nair C. Hepatoprotective activity of Andrographis paniculata and Swertia chirayita. Food Chem Toxicol. 2011;49:3367-73 pubmed publisher
    Andrographis paniculata (Family: Acanthaceae) and Swertia chirayita (Family: Gentianaceae) are two controversial medicinal plants used as Kiriyattu, having similar therapeutic action and are used as a hepatoprotective and ..

More Information

Publications114 found, 100 shown here

  1. Wan L, Chen C, Xiao Z, Wang Y, Min Q, Yue Y, et al. In vitro and in vivo anti-diabetic activity of Swertia kouitchensis extract. J Ethnopharmacol. 2013;147:622-30 pubmed publisher
    b>Swertia kouitchensis has long been used as a folk medicine to treat hepatitis and diabetes in central-western China. Therefore, this study was aimed to evaluate the anti-diabetic activity of the plant ethanol extract.
  2. Saha P, Mandal S, Das A, Das P, Das S. Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model. Phytother Res. 2004;18:373-8 pubmed
    ..The present study reports the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant...
  3. Wang Z, Ma C, Tang S, Xiao H, Kakiuchi N, Kida H, et al. Qualitative and quantitative analysis of Swertia herbs by high performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS). Chem Pharm Bull (Tokyo). 2008;56:485-90 pubmed
    We evaluated the composition of Swertia herbs using high performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS)...
  4. Verma H, Patil P, Kolhapure R, Gopalkrishna V. Antiviral activity of the Indian medicinal plant extract Swertia chirata against herpes simplex viruses: a study by in-vitro and molecular approach. Indian J Med Microbiol. 2008;26:322-6 pubmed
    The antiviral activity of Indian Medicinal plant extract Swertia chirata was tested against Herpes simplex virus (HSV) type-1, using multiple approaches both at cellular and molecular level.
  5. Tian L, Bai X, Chen X, Fang J, Liu S, Chen J. Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism. Phytomedicine. 2010;17:533-9 pubmed publisher
    In this study, we continued to investigate the hypoglycemic activity of Swertia punicea Helmsl...
  6. Phoboo S, Pinto M, Barbosa A, Sarkar D, Bhowmik P, Jha P, et al. Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst. Phytother Res. 2013;27:227-35 pubmed publisher
    The crude extract of Swertia chirayita, an important medicinal plant of Nepal, is locally used for many diseases including type 2 diabetes. In this study, crude aqueous and 12% ethanol solution extracts of S...
  7. Hajimehdipoor H, Dijoux Franca M, Mariotte A, Amanzadeh Y, Sadat Ebrahimi S, Ghazi Khansari M. Two new xanthone diglycosides from Swertia longifolia Boiss. Nat Prod Res. 2006;20:1251-7 pubmed
    From aerial parts of Swertia longifolia Boiss., which grows in the north of Iran, five xanthones, two of which in diglycosidic form, were isolated...
  8. Chen Y, Huang B, He J, Han L, Zhan Y, Wang Y. In vitro and in vivo antioxidant effects of the ethanolic extract of Swertia chirayita. J Ethnopharmacol. 2011;136:309-15 pubmed publisher
    b>Swertia chirayita, a medicinal herb endemic to the Tibetan region, is used as a special remedy for liver disorders. The hepatoprotective activity of its plant extracts has been associated with its antioxidant activity...
  9. Zhang Y, Zhao H, Li H, Cao W, Wang F, Zhang T, et al. Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Molecules. 2017;22: pubmed publisher
    Amarogentin, a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots, has been suggested to exhibit many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities...
  10. Ahluwalia V, Elumalai S, Kumar V, Kumar S, Sangwan R. Nano silver particle synthesis using Swertia paniculata herbal extract and its antimicrobial activity. Microb Pathog. 2018;114:402-408 pubmed publisher
    In the present study, green synthesis of silver nanoparticles (AgNPs) is demonstrated using medicinal herb Swertia paniculata extract...
  11. Tan G, Xu K, Li F, Xu P, Hu G, Jiang D, et al. [Daviditin B from Swertia davidi Franch]. Yao Xue Xue Bao. 2003;38:931-3 pubmed
    To study the active constituents of Swertia davidi Franch. Chemical components were isolated by column chromatography and their structures were established mainly by spectroscopic means (UV, IR, NMR, 2D-NMR, MS)...
  12. Takei H, Nakauchi K, Yoshizaki F. Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis. Anal Sci. 2001;17:885-8 pubmed
    b>Swertia herb (florescent whole plantof Swertia japonica, Gentianaceae) has long been utilized as a folk medicine in Japan. It is often blended in general gastroenteric drugs as a bitter stomachic...
  13. Wang H, Geng C, Ma Y, Zhang X, Chen J. Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma. Fitoterapia. 2013;89:183-7 pubmed publisher
    Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR)...
  14. Shi G, Wang G, Chen X. Screening of radical-scavenging natural neuroprotective antioxidants from Swertia chirayita. Acta Biol Hung. 2013;64:267-78 pubmed publisher
    To detect and identify natural antioxidants in Swertia chirayita with protective effect against cerebral infarction, a screening method, using column chromatography and cerebral ischemia-reperfusion injury in rat, was developed...
  15. Chen T, Li H, Chen C, Wei L, Li Y. Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its α-Glucosidase Inhibitory Activity. J Chromatogr Sci. 2017;55:638-644 pubmed publisher
    Large-scale preparation and α-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study...
  16. Moon K, Lee B, Cho W, Lee B, Kim C, Ma J. Swertiajaponin as an anti-browning and antioxidant flavonoid. Food Chem. 2018;252:207-214 pubmed publisher
    ..Although swertiajaponin is a flavonoid rich in the whole herb of Swertia japonica that has been clinically used, its biological functions and applicat?ion in the foods have not been ..
  17. Luo C, Mao S, Liu F, Yang M, Chen H, Kurihara H, et al. Antioxidant xanthones from Swertia mussotii, a high altitude plant. Fitoterapia. 2013;91:140-147 pubmed publisher
    ..4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses...
  18. Tamhankar S, Ghate V, Raut A, Rajput B. Molecular profiling of "Chirayat" complex using Inter Simple Sequence Repeat (ISSR) markers. Planta Med. 2009;75:1266-70 pubmed publisher
    quot;Chirayat" represents a group in which different species of Swertia and some other non-Swertia species are used as local substitutes/adulterants for the Swertia chirayita...
  19. Wu X, Gu Y, Li L. The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats. Toxicol Lett. 2017;265:9-16 pubmed publisher
    Qing Ye Dan (QYD) is the whole plant of Swertia mileensis and used in Chinese folk medicine for the treatment of prostatitis, benign prostatic hyperplasia (BPH) and so on...
  20. Xiang B, Li X, Wang Y, Tian X, Yang Z, Ma L, et al. Cloning and Characterization of Two Iridoid Synthase Homologs from Swertia Mussotii. Molecules. 2017;22: pubmed publisher
    i>Swertia mussotii is an important medicinal plant found on the Qinghai Tibetan Plateau that has great economic and medicinal value. This plant has enjoyed a long history of use as a curative for hepatitis...
  21. Negi J, Singh P, Nee Pant G, Rawat M. Study on the variations of mineral elements in Swertia speciosa (G. Don). Biol Trace Elem Res. 2010;138:300-6 pubmed publisher
    Variations of micro- and macrominerals concentration in Swertia speciosa were determined by atomic absorption spectroscopy. The mineral elements showed significant changes in roots and leaves collected from different altitudes...
  22. Patro B, Chintalwar G, Chattopadhyay S. Antioxidant activities of Swertia decussata xanthones. Nat Prod Res. 2005;19:347-54 pubmed
    The lipid peroxidation inhibitory activities of four hydroxyxanthones, isolated from the whole plant Swertia decussata, were evaluated for the first time...
  23. Jayasundar R, Ghatak S, Makhdoomi M, Luthra K, Singh A, Velpandian T. Challenges in integrating component level technology and system level information from Ayurveda: Insights from NMR phytometabolomics and anti-HIV potential of select Ayurvedic medicinal plants. J Ayurveda Integr Med. 2018;: pubmed publisher
    ..Six medicinal plants (Azadirachta indica, Tinospora cordifolia, Swertia chirata, Terminalia bellerica, Zingiber officinale and Symplocos racemosa) were studied using high resolution ..
  24. Kimura Y, Sumiyoshi M. Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice. Fitoterapia. 2011;82:827-33 pubmed publisher
    The Swertia japonica is used clinically as a remedy for gastrointestinal symptoms in Japan. We examined the effects of a S...
  25. Xu G, Li H, He J, Feng E, Shi P, Liu Y, et al. Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid. J Ethnopharmacol. 2013;149:49-54 pubmed publisher
    ..05) among the three types of swertiamarin administration. The data indicate that oleanolic acid and the other ingredients present in QYDT could affect the pharmacokinetic behaviour of swertiamarin in rats. ..
  26. Lee H, Jeon S, Ryu B, Park S, Ko S, Lee Y, et al. Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. Behav Brain Res. 2016;306:137-45 pubmed publisher
    Swertisin, a C-glucosylflavone isolated from Swertia japonica, has been known to have anti-inflammatory or antidiabetic activities. Until yet, however, its cognitive function is not investigated...
  27. Wang J, Zhao C, Liu C, Xia G, Xiang F. Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization. BMC Plant Biol. 2011;11:71 pubmed publisher
    The wild herb Swertia mussotii is a source of the anti-hepatitis compounds swertiamarin, mangiferin and gentiopicroside. Its over-exploitation has raised the priority of producing these compounds heterologously...
  28. Zhu B, Zhe W, Duan Y, Wang M, Gao Y, Wei G, et al. Two new xanthones from Swertia angustifolia. J Asian Nat Prod Res. 2012;14:154-8 pubmed publisher
    Two new xanthones, angustins A and B (1 and 2), were isolated from the aerial parts of Swertia angustifolia together with six known compounds (3-8)...
  29. Pal T, Padhan J, Kumar P, Sood H, Chauhan R. Comparative transcriptomics uncovers differences in photoautotrophic versus photoheterotrophic modes of nutrition in relation to secondary metabolites biosynthesis in Swertia chirayita. Mol Biol Rep. 2018;45:77-98 pubmed publisher
    b>Swertia chirayita is a high-value medicinal herb exhibiting antidiabetic, hepatoprotective, anticancer, antiediematogenic and antipyretic properties...
  30. Jiang D, Jiang J, Zhu H, Tan G, Liu S, Xu K, et al. Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. J Ethnopharmacol. 2004;93:295-306 pubmed
    ..the anti-oxidation and protective effects of demethylbellidifolin (DMB), a xanthone compound extracted from swertia davidi Franch, on endothelium...
  31. Cao Y, Wang Y, Ye J. Differentiation of Swertia Mussotii Franch from Artemisiae Capillaris Herba by capillary electrophoresis with electrochemical detection. J Pharm Biomed Anal. 2005;39:60-5 pubmed
    ..capillary electrophoresis (CE) with electrochemical detection (ED) method is developed for differentiation of Swertia Mussotii Franch from Artemisiae Capillaris Herba in this work...
  32. Jiang D, Jiang J, Tan G, Du Y, Xu K, Li Y. Protective effects of daviditin A against endothelial damage induced by lysophosphatidylcholine. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:600-6 pubmed
    ..The present results suggest that daviditin A preserves endothelial dysfunction elicited by LPC, and the protective effect of daviditin A on the endothelium is related to reduction of ADMA concentration. ..
  33. Yu M, Wong K, Zong Y, Shaw P, Che C. Identification of Swertia mussotii and its adulterant Swertia species by 5S rRNA gene spacer. Zhongguo Zhong Yao Za Zhi. 2008;33:502-4 pubmed
    This research focused on analyzing the differences of 5S rRNA gene spacer sequences on Swertia mussotii and its commonly used adulterants, including S. franchetiana, S. wolfangiana and S. chirayita...
  34. Shi R, Li X, Jia S, Fu Q, Chen Y, Chen J, et al. Demethylbellidifolin prevents nitroglycerin tolerance via improved aldehyde dehydrogenase 2 activity. Planta Med. 2009;75:1476-81 pubmed publisher
    The aim of this study was to investigate the effect of demethylbellidifolin (DMB), a major xanthone compound of Swertia davidi franch, on nitroglycerin (NTG) tolerance...
  35. Li J, Zhao Y, Huang H, Wang Y. Phytochemistry and Pharmacological Activities of the Genus Swertia (Gentianaceae): A Review. Am J Chin Med. 2017;45:667-736 pubmed publisher
    b>Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries...
  36. You R, Chen X, He D, Huang C, Jin Y, Qian S, et al. [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong Yao Za Zhi. 2017;42:3764-3769 pubmed publisher
    The present work is to study the chemical constituents from petroleum ether fraction of Tibetan medicine Swertia chirayita by column chromatography and recrystallization...
  37. Saha P, Das S. Highlighting the anti-carcinogenic potential of an ayurvedic medicinal plant, Swertia Chirata. Asian Pac J Cancer Prev. 2010;11:1445-9 pubmed
    b>Swertia chirata is a plant with bitter taste used since an early date in traditional medical systems of our country for treatment of varied human ailments...
  38. Wang H, He K, Geng C, Zhang X, Ma Y, Luo J, et al. Gentiocrucines A-E, five unusual lactonic enamino Ketones from Swertia macrosperma and Swertia angustifolia. Planta Med. 2012;78:1867-72 pubmed publisher
    Five unusual lactonic enamino ketones, gentiocrucines A-E (1-5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR)...
  39. Li Y, Shang M, Chen J, Cai S. Application of microscopy for discrimination of eight Swertia species utilized in the traditional Chinese medicine "Qingyedan". Microsc Res Tech. 2013;76:296-310 pubmed publisher
    Many Swertia species are utilized as a traditional medicine under the name "Qingyedan" in China, but are easily confused with one another. To distinguish eight Swertia species (S. mileensis, S. cincta, S. patens, S. punicea, S...
  40. Xu L, Sheng T, Liu X, Zhang T, Wang Z, Han H. Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes. J Ethnopharmacol. 2017;209:91-99 pubmed publisher
    b>Swertia cincta Burkill was traditionally used for treating jaundice and various types of chronic and acute hepatitis in Yunnan and Tibet in China for hundreds of years. This study aims to investigate the protective effect of S...
  41. Kumar P, Paul B, Kumar S, Ali M, Sexana A. Correlation of cytokine and mobility in mice with arthritis and during therapy with Swertia chirayita. J Herb Pharmacother. 2004;4:33-45 pubmed
    ..derive a correlation between pro-inflammatory cytokines and mobility in arthritic mice and after treatment with Swertia chirayita plant extract...
  42. Xue C, Li D, Lu J, Yang J, Liu J. Molecular authentication of the traditional Tibetan medicinal plant Swertia mussotii. Planta Med. 2006;72:1223-6 pubmed
    b>Swertia mussotii is an important species in Tibetan folk medicine...
  43. Huang W, Xu C, Zhou D, Tong L, Ye Z. [Determination of iridoids and triterpenes in herb of Swertia pseudochinesis by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2007;32:2494-6 pubmed
    ..method for the determination of swertiamarin, sweroside, gentiopicrin and oleanolic acid in different parts of Swertia pseudochinesis. A Zorbax SB-C18 (4...
  44. Zhang J, Wang X, Dong X, Yang H, Li G. [Studies on chemical constituents of Swertia mussotii]. Zhong Yao Cai. 2009;32:511-4 pubmed
    To study the chemical constituents of Swertia mussotii. The constituents were isolated by various column chromatography methods, and their structures were identified by physico-chemical properties and spectral analysis...
  45. Geng C, Zhang X, Ma Y, Jiang Z, Liu J, Zhou J, et al. Three new secoiridoid glycoside dimers from Swertia mileensis. J Asian Nat Prod Res. 2010;12:542-8 pubmed publisher
    Three new secoiridoid glycoside dimers named swerilactosides A-C (1-3) were isolated from Swertia mileensis. Their structures were elucidated based on extensive spectral analyses (1D and 2D NMR, MS, and IR spectroscopic means).
  46. Jiang F, Zhang X, Ma Y, Geng C, Jiang Z, Chen J. [Chemical constituents of Swertia hispidicalyx]. Zhongguo Zhong Yao Za Zhi. 2011;36:2215-8 pubmed
    To study the chemical constituents of Swertia hispidicalyx. The EtOAc part of S...
  47. Liu L, Xu G, Ma X, Khan A, Tan W, Yang Z, et al. Sweritranslactones A-C, Unusual Skeleton Secoiridoid Dimers via [4+2] Cycloaddition from Swertiamarin. J Org Chem. 2017;: pubmed publisher
    ..hexacyclic skeleton and were obtained from swertiamarin, one of the major constituents of the genus Swertia, via a [4+2] cycloaddition and intramolecular nucleophilic addition in aqueous conditions...
  48. Bao Y, Ji W, Ma Y, Ji L. [Simultaneous determination of six main constituents in Swertia of Qinghai Province and Sichuan Province by HPLC]. Zhongguo Zhong Yao Za Zhi. 2006;31:2036-8 pubmed
    ..of swertiamarin, gentiopicroside, mangiferin, swertianolin, isoorientin, 1,8-drihydroxy-3-methoxy-xthanone in Swertia from Qinghai province and Sichuan province by HPLC. The samples were separated on the column of Kromasil C18 (4...
  49. Singh P, Ambika -, Chauhan S. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Nat Prod Res. 2012;26:1682-6 pubmed publisher
    ..process was used to identify the DPPH (l,l-diphenyl-2-picrylhydrazyl) radical-scavenging components of Swertia chirayita. A dry, whole plant of S...
  50. Beniwal P, Gaur N, Singh S, Raveendran N, Malhotra V. How Harmful Can Herbal Remedies Be? A Case of Severe Acute Tubulointerstitial Nephritis. Indian J Nephrol. 2017;27:459-461 pubmed publisher
    ..Hyponidd is an ayurvedic drug containing Momordica charantia, Gymnema sylvestre, Swertia chirata, etc...
  51. Kikuchi M, Kikuchi M. Studies on the constituents of Swertia japonica MAKINO I. On the structures of new secoiridoid diglycosides. Chem Pharm Bull (Tokyo). 2004;52:1210-4 pubmed
    ..12), were isolated, together with five known compounds from the whole plants of Swertia japonica MAKINO...
  52. Liu Y, Xu Q, Xue X, Zhang F, Liang X. Two-dimensional LC-MS analysis of components in Swertia franchetiana Smith. J Sep Sci. 2008;31:935-44 pubmed publisher
    An off-line 2-D-LC approach was developed for the separation and identification of components in extracts of Swertia franchetiana Smith, which is a traditional Chinese medicine...
  53. Li T, Wang Y, Yu H, Cao Y, Zhang J, Liu Q. [Determination of eight trace elements in the Swertia davidii Franch by flame atomic absorption spectrometry]. Guang Pu Xue Yu Guang Pu Fen Xi. 2007;27:2598-600 pubmed
    The effects of different sample digestives on the determination of Swertia davidii Franch are compared. Eight trace elements in the Swertia davidii Franch were determined by flame atomic absorption spectrometry...
  54. Du X, Wang W, Zhang S, Pu X, Zhang Q, Ye M, et al. Neuroprotective xanthone glycosides from Swertia punicea. J Nat Prod. 2010;73:1422-6 pubmed publisher
    ..puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1-5 were determined by HRESIMS and NMR spectroscopic methods...
  55. Khan A, Rahim A, Iqbal Z, Gilani A. Insights into mechanisms underlying the gut and airways modulatory effects of Swertia chirata. J Nat Med. 2012;66:140-8 pubmed publisher
    b>Swertia chirata is used in folk medicine for the treatment of constipation, colic, diarrhea, and asthma...
  56. Kakiuchi N, Iwaki N, Mikage M, Xiao H, Wang Z, Hattori M. Phylogenetic examination of crude drugs derived from Yunnanese Swertia plants. J Nat Med. 2014;68:206-10 pubmed publisher
    Aiming to examine whether the genetic background of the crude drugs derived from four Yunnanese Swertia plants and their chemical constituent profiles correlate, we analyzed the nucleotide sequences of their nuclear ribosomal DNA regions ..
  57. Jauhari N, Bharadvaja N, Sharma N. Swertia chirata: A comprehensive review with recent advances. Curr Pharm Biotechnol. 2017;: pubmed publisher
    b>Swertia chirata, an ethnomedicinal plant, is renowned for its diverse medicinal properties...
  58. Jiang D, Tan G, Ye F, Du Y, Xu K, Li Y. Protective effects of xanthones against myocardial ischemia-reperfusion injury in rats. Acta Pharmacol Sin. 2003;24:175-80 pubmed
    ..To investigate the protective effect of xanthones against myocardial ischemia-reperfusion injury in rats...
  59. Zeng G, Tan G, Xu K, Xu X, Li F, Tan J, et al. [Water-soluble chemical constituents of Swertia davidi Franch]. Yao Xue Xue Bao. 2004;39:351-3 pubmed
    To study the active constituents of Swertia davidi Franch.
  60. Suryawanshi S, Asthana R, Gupta R. Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;858:211-9 pubmed
    Extracts from Swertia chirata (family Gentianaceae) have antidiabetics and antioxidant activity, largely attributed to the flavonoids and secoiridoids, which are a major class of functional components in methanolic extracts from aerial ..
  61. Negi J, Singh P, Rawat M, Geeta J. Study on the trace elements in Swertia chirayita (Roxb.) H. Karsten. Biol Trace Elem Res. 2010;133:350-6 pubmed publisher
    ..made to analyze some trace elements and electrolytes like Zn, Cu, Mn, Fe, Co, Na, K, Ca, and Li present in the Swertia chirayita roots and leaves. The concentration of Ca in all the samples was more than 1,346...
  62. Misra A, Shasany A, Shukla A, Darokar M, Singh S, Sundaresan V, et al. AFLP markers for identification of Swertia species (Gentianaceae). Genet Mol Res. 2010;9:1535-44 pubmed publisher
    The genus Swertia is well known for its medicinal properties, as described in the Indian pharmacopoeia...
  63. Zhang S, Du X, Pu X. 3-O-demethylswertipunicoside protects against oxidative toxicity in PC12 cells. Biol Pharm Bull. 2010;33:1529-33 pubmed
    ..The xanthone compound 3-O-demethylswertipunicoside (3-ODS), extracted from Swertia punicea HEMSL, has not previously been demonstrated to have clear neuroprotective effects...
  64. Li J, Feng L, Sun B, Ikeda T, Nohara T. Hepatoprotective activity of the constituents in Swertia pseudochinensis. Biol Pharm Bull. 2005;28:534-7 pubmed
    A new xanthone derivative was isolated together with other 13 known constituents from a Chinese natural medicine, Swertia pseudochinensis HARA. Their structures were determined based on the spectral and chemical evidences...
  65. Ji W, Lu X, Chen G, Ji L. [Study on HPLC fingerprint of Swertia mussotii var. mussotii from north-west area of Sichuan Province I]. Zhongguo Zhong Yao Za Zhi. 2005;30:977-9 pubmed
    To constitute HPLC fingerprint of the methanol extract from Swertia mussotii grown in Sichuan Province.
  66. Chintalwar G, Chattopadhyay S. Structural confirmation of decussatin, a Swertia decussata xanthone. Nat Prod Res. 2006;20:53-6 pubmed
    Reinvestigation of the plant, Swertia decussata resulted in the isolation of four antioxidant xanthones, which were characterized as 1-hydroxy-3,7,8-trimethoxy, 1,8-dihydroxy-3,7-dimethoxy, 1,7-dihydroxy-3,8-dimethoxy and 1,7,8-..
  67. Suryawanshi S, Mehrotra N, Asthana R, Gupta R. Liquid chromatography/tandem mass spectrometric study and analysis of xanthone and secoiridoid glycoside composition of Swertia chirata, a potent antidiabetic. Rapid Commun Mass Spectrom. 2006;20:3761-8 pubmed
    b>Swertia chirata is a bitter plant, used in the Indian system of medicine (Ayurveda) for various human ailments...
  68. Zhang L, Xia C, Liu G. [Investigation on medicinal plant resources of Swertia in Yunnan province]. Zhongguo Zhong Yao Za Zhi. 2009;34:674-6 pubmed
    To explore the species and distribution of medicinal plants Swertia in Yunnan province, and provide scientific basis for sustainable utilization.
  69. Xu K, Shen J, Li F, Liu J, Liu G, Tan J, et al. [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection]. Zhongguo Zhong Yao Za Zhi. 2009;34:1384-9 pubmed
    To develop an HPLC method for the quantification of six active components in three species (Swertia davidi, S. nervosa and S. mussotii) .
  70. Jiang L, Cai Y, Xia G, Xiang F. Introgression of the heterologous nuclear DNAs and efficacious compositions from Swertia tetraptera Maxim. into Bupleurum scorzonerifolium Willd. via somatic hybridization. Protoplasma. 2012;249:737-45 pubmed publisher
    b>Swertia tetraptera Maxim. is an important source of secoiridoid glucosides. To produce these pharmacologically valuable compounds heterologously in somatic hybrid cell lines, S...
  71. Menkovic N, Savikin Fodulović K, Bulatović V, Aljancić I, Juranic N, Macura S, et al. Xanthones from Swertia punctata. Phytochemistry. 2002;61:415-20 pubmed
    ..methylbellidifolin, isoswertianin, methylswertianin and norswertianin-1-O-beta-D-glucoside, from the roots of Swertia punctata is reported...
  72. Wang S, Han X, Xu Q, Xiao H, Liu X, Du Y, et al. Xanthone glycosides from Swertia franchetiana. J Asian Nat Prod Res. 2005;7:175-9 pubmed
    A new xanthone glycoside (1) has been isolated from Swertia franchetiana together with five known xanthone glycosides...
  73. Hajimehdipoor H, Sadeghi Z, Elmi S, Elmi A, Ghazi Khansari M, Amanzadeh Y, et al. Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice. J Pharm Pharmacol. 2006;58:277-80 pubmed
    Aerial parts of Swertia longifolia Boiss. (Gentianaceae), which grows in the north of Iran, were screened for hepatoprotective activity against paracetamol (acetaminophen)-induced hepatotoxicity in Swiss mice...
  74. Saha P, Mandal S, Das A, Das S. Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model. Cancer Lett. 2006;244:252-9 pubmed
    b>Swertia chirata, is a bitter plant, used in the Indian system of medicine (Ayurveda) for various human ailments. Our laboratory was the first to report the chemopreventive effect of this plant...
  75. Iqbal Z, Lateef M, Khan M, Jabbar A, Akhtar M. Anthelmintic activity of Swertia chirata against gastrointestinal nematodes of sheep. Fitoterapia. 2006;77:463-5 pubmed
    This paper describes in vitro and in vivo anthelmintic activities of Swertia chirata. In vitro studies revealed that at 25 mg/ml (P>/=0.05) the crude aqueous (CAE) and methanolic extracts (CME) of S...
  76. Zhang D, Chen S, Chen S, Zhang D, Gao Q. Patterns of genetic variation in Swertia przewalskii, an endangered endemic species of the Qinghai-Tibet Plateau. Biochem Genet. 2007;45:33-50 pubmed
    b>Swertia przewalskii Pissjauk. (Gentianaceae) is a critically endangered and endemic plant of the Qinghai-Tibet Plateau in China...
  77. Uvarani C, Chandraprakash K, Sankaran M, Ata A, Mohan P. Antioxidant and structure-activity relationships of five tetraoxygenated xanthones from Swertia minor (Griscb.) Knobl. Nat Prod Res. 2012;26:1265-70 pubmed publisher
    Antioxidant activity-guided fractionations of chloroform extract of Swertia minor yielded five known tetraoxygenated xanthones (1-5), of which compound 3 was isolated for the first time from plant sources...
  78. Cao T, Geng C, Jiang F, Ma Y, He K, Zhou N, et al. Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity. Fitoterapia. 2013;89:175-82 pubmed publisher
    ..A (1), sweriyunnanosides A (2), B (3) and C (4), along with nineteen known compounds (5-23) were isolated from Swertia yunnanensis...
  79. Wan L, Min Q, Wang Y, Yue Y, Chen J. Xanthone glycoside constituents of Swertia kouitchensis with ?-glucosidase inhibitory activity. J Nat Prod. 2013;76:1248-53 pubmed publisher
    ..glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis...
  80. Tan G, Xu K, Xu P, Hu G, Li Y. [Studies of the chemical constituents of Swertia davida Franch]. Yao Xue Xue Bao. 2002;37:630-2 pubmed
    To study the active constituents of Swertia davidi Franch..
  81. Qing Z, Jiachun C, Yanwen L. [Study on chemical constituents from Swertia kauitchensis Franch]. Zhong Yao Cai. 2004;27:908-10 pubmed
    To study the major chemical constituents from the whole herb of Swertia kauitchensis Franch.
  82. Lei Y, Gao M, Wang L, Xiao H. [Preparation of gentiopicroside from the extract of Swertia mussotii Franch by preparative high performance liquid chromatography]. Se Pu. 2010;28:902-4 pubmed
    A new method for isolation of gentiopicroside (GPS) from Swertia mussotii Franch with reversed phase preparative high performance liquid chromatography (Pre-HPLC) is described...
  83. Wang H, Geng C, Zhang X, Ma Y, Jiang Z, Chen J. [Chemical constituents of Swertia macrosperma]. Zhongguo Zhong Yao Za Zhi. 2010;35:3161-4 pubmed
    To study the chemical constituents of Swertia macrosperma.
  84. He K, Ma Y, Cao T, Wang H, Jiang F, Geng C, et al. Seven new secoiridoids with anti-hepatitis B virus activity from Swertia angustifolia. Planta Med. 2012;78:814-20 pubmed publisher
    ..1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia...
  85. Wang Y, Xiao Z, Liu S, Wan L, Yue Y, Zhang Y, et al. Antidiabetic effects of Swertia macrosperma extracts in diabetic rats. J Ethnopharmacol. 2013;150:536-44 pubmed publisher
    b>Swertia macrosperma is a traditional folk medicine used for its anti-hepatitis, antipyretic and antidotal effects as "Dida" or "Zangyinchen" in Tibet, Yunnan and Guizhou province for a long time, and it has been ..
  86. Geng C, Chen X, Zhou N, Chen H, Ma Y, Huang X, et al. LC-MS guided isolation of (±)-sweriledugenin A, a pair of enantiomeric lactones, from Swertia leducii. Org Lett. 2014;16:370-3 pubmed publisher
    Sweriledugenin A, a pair of novel enantiomeric lactones, were isolated from Swertia leducii under the guidance of LC-MS investigation. The enantiomeric separation was achieved by HPLC on a chiral column...
  87. Jiang D, Jiang J, Tan G, Huang Z, Deng H, Li Y. Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level. Planta Med. 2003;69:1150-2 pubmed
    The effect of demethylbellidifolin (DMB), a major compound of Swertia davidi Franch, on the adhesion of monocytes to endothelial cells induced by oxidized low-density lipoprotein (ox-LDL) was studied...
  88. Longxing W, LeFeng Z, Shisheng W, Hongbin X, Xinmiao L. Discriminating the xanthones in an extract of Swertia franchetiana by retention parameters. Phytochem Anal. 2005;16:34-8 pubmed
    ..this paper, retention parameters of components were used to discriminate the xanthones in a methanol extract of Swertia franchetiana The extract was analysed by HPLC under two different multistage linear gradient conditions and the ..
  89. Song Y, Hu F, Lin P, Lu Y, Shi Z. [Determination of xanthones in Swertia mussotii and Swertia franchetiana by high performance liquid chromatography]. Se Pu. 2004;22:51-3 pubmed
    A simple and rapid method for simultaneous separation and determination of xanthones in Swertia mussotii and Swertia franchetiana by high performance liquid chromatography has been established...
  90. Xia C, Liu G, Zhang H. [Chemical constituents from herbs of Swertia delavayi]. Zhongguo Zhong Yao Za Zhi. 2008;33:1988-90 pubmed
    To isolate and identify the chemical constituents of 95% alcohol extract from Swertia delavayi.
  91. Alam K, Ali M, Parvin S, Mahjabeen S, Akbar M, Ahamed R. In vitro antimicrobial activities of different fractions of Swertia chirata ethanolic extract. Pak J Biol Sci. 2009;12:1334-7 pubmed
    ..study was to evaluate the in vitro antimicrobial activity of pet-ether, dichloromethane and methanol fractions of Swertia chirata (Family: Gentianaceae) ethanolic extract...
  92. Li G, Zhang X, You J, Song C, Sun Z, Xia L, et al. Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extracti. Anal Chim Acta. 2011;688:208-18 pubmed publisher
    ..as an efficient tool was employed to optimize the ultrasonic-assisted extraction of triterpenic acids from Swertia plants and the pre-column derivatization reaction, respectively, which ensured the highest triterpenic acids ..