gentiana

Summary

Summary: A plant genus of the family Gentianaceae whose members contain SECOIRIDOIDS and have been used in TRADITIONAL MEDICINE for suppressing INFLAMMATION.

Top Publications

  1. Wang Y, Wang Y, Liu J, Yan S, Sun C, Xu S. [Preparative separation of gentiopicrin from Gentiana scabra bunge by high speed counter current chromatography]. Zhong Yao Cai. 2007;30:789-91 pubmed
    ..speed counter current chromatography was successfully applied to the preparative separation of the component of Gentiana scabra Bunge...
  2. Ozturk N, Baser K, Aydin S, Ozturk Y, Calis I. Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice. Phytother Res. 2002;16:627-31 pubmed
    A methanolic extact of Gentiana lutea ssp. symphyandra roots has been investigated for its possible effects on the central nervous system of mice. At doses of 250 and 500 mg/kg (i.p...
  3. Sezik E, Aslan M, Yesilada E, Ito S. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci. 2005;76:1223-38 pubmed
    Hypoglycemic effect of Gentiana olivieri Griseb. (Gentianaceae) flowering herbs on oral administration were studied using in vivo models in normal, glucose-hyperglycemic and streptozotocin-induced diabetic rats...
  4. Mikula A, Tykarska T, Kuras M. Ultrastructure of Gentiana tibetica proembryogenic cells before and after cooling treatments. Cryo Letters. 2005;26:367-78 pubmed
    ..M sorbitol, DMSO and vitrification solution (PVS2) on the ultrastructure of non-frozen and frozen suspensions of Gentiana tibetica King ex Hook. F.tissue cells was investigated...
  5. Tiwari R, Trivedi M, Guang Z, Guo G, Zheng G. Genetic transformation of Gentiana macrophylla with Agrobacterium rhizogenes: growth and production of secoiridoid glucoside gentiopicroside in transformed hairy root cultures. Plant Cell Rep. 2007;26:199-210 pubmed
    Hairy root cultures of Gentiana macrophylla were established by infecting the different explants four Agrobacterium rhizogenes strains namely A(4)GUS, R1000, LBA 9402 and ATCC11325, and hairy root lines were established with A...
  6. Mikula A, Olas M, Sliwinska E, Rybczynski J. Cryopreservation by encapsulation of Gentiana spp cell suspensions maintains regrowth, embryogenic competence and DNA content. Cryo Letters. 2008;29:409-18 pubmed
    ..technique for cryopreservation by encapsulation was developed for two suspension cultures of gentian species (Gentiana tibetica and G. cruciata) of different ages and embryogenic potential...
  7. Savikin K, Menkovic N, Zdunic G, Stević T, Radanović D, Jankovic T. Antimicrobial activity of Gentiana lutea L. extracts. Z Naturforsch C. 2009;64:339-42 pubmed
    Methanolic extracts of flowers and leaves of Gentiana lutea L., together with the isolated compounds mangiferin, isogentisin and gentiopicrin, were used to investigate the antimicrobial activity of the plant...
  8. Pathirana R, Frew T, Hedderley D, Timmerman Vaughan G, Morgan E. Haploid and doubled haploid plants from developing male and female gametes of Gentiana triflora. Plant Cell Rep. 2011;30:1055-65 pubmed publisher
    ..were developed for the generation of haploid or doubled haploid plants from developing microspores and ovules of Gentiana triflora...
  9. Hudecova A, Kusznierewicz B, Rundén Pran E, Magdolenova Z, Hasplova K, Rinna A, et al. Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea. Mutagenesis. 2012;27:759-69 pubmed publisher
    ..Oxidised DNA base lesions and strand breaks caused by AgNPs were diminished by aqueous and methanolic extracts from both haulm and flower of Gentiana asclepiadea.

More Information

Publications105 found, 100 shown here

  1. Orhan D, Aslan M, Aktay G, Ergun E, Yesilada E, Ergun F. Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle. Life Sci. 2003;72:2273-83 pubmed
    Hepatoprotective effect of Gentiana olivieri Griseb. (Gentianaceae) flowering herbs on subacute administration were studied using in vivo models in rats...
  2. Ozturk N, Korkmaz S, Ozturk Y, Baser K. Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Planta Med. 2006;72:289-94 pubmed
    Wound healing properties of Gentian (Gentiana lutea ssp...
  3. Aberham A, Schwaiger S, Stuppner H, Ganzera M. Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS. J Pharm Biomed Anal. 2007;45:437-42 pubmed
    ..46-9.53%), followed by loganic acid (0.10-0.76%), swertiamarin (0.21-0.45%) and the xanthone glycosides. Gentisin and isogentisin were found in much lower concentrations between 0.02 and 0.11%, respectively...
  4. Nakatsuka T, Sato K, Takahashi H, Yamamura S, Nishihara M. Cloning and characterization of the UDP-glucose:anthocyanin 5-O-glucosyltransferase gene from blue-flowered gentian. J Exp Bot. 2008;59:1241-52 pubmed publisher
    Blue-flowered gentian (Gentiana triflora) is known to accumulate gentiodelphin, a unique polyacylated delphinidin-type anthocyanin, in the petals...
  5. Akileshwari C, Muthenna P, Nastasijevic B, Joksic G, Petrash J, Reddy G. Inhibition of aldose reductase by Gentiana lutea extracts. Exp Diabetes Res. 2012;2012:147965 pubmed publisher
    ..b>Gentiana lutea grows naturally in the central and southern areas of Europe...
  6. Wani B, Ramamoorthy D, Rather M, Arumugam N, Qazi A, Majeed R, et al. Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (??m) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. Phytomedicine. 2013;20:723-33 pubmed publisher
    The objective of the current study was to evaluate the methanolic root extract of Gentiana kurroo for antioxidant and antiproliferative activities as well as to study the effect of the extract on the induction of apoptosis in human ..
  7. Toriumi Y, Kakuda R, Kikuchi M, Yaoita Y, Kikuchi M. New triterpenoids from Gentiana lutea. Chem Pharm Bull (Tokyo). 2003;51:89-91 pubmed
    ..acid, and betulin 3-O-palmitate, have been isolated from the rhizomes and roots of Gentiana lutea, together with five known ones...
  8. Wu Q, Li Y, Shi Y. Antioxidant phenolic glucosides from Gentiana piasezkii. J Asian Nat Prod Res. 2006;8:391-6 pubmed
    An extract of Gentiana piasezkii afforded a new arbutin derivative 6'-O-vanilloylarbutin (1) and a new flavone-C-glucoside 7-O-feruloylorientin (2), together with four known flavonoids lutonarin (3), saponarin (4), isoorient (5) and ..
  9. Nastasijevic B, Lazarevic Pasti T, Dimitrijević Branković S, Pasti I, Vujacić A, Joksic G, et al. Inhibition of myeloperoxidase and antioxidative activity of Gentiana lutea extracts. J Pharm Biomed Anal. 2012;66:191-6 pubmed publisher
    The aim of this study was to investigate the inhibitory activity of Gentiana lutea extracts on the enzyme myeloperoxidase (MPO), as well as the antioxidant activity of these extracts and their correlation with the total polyphenol content...
  10. Hudecova A, Kusznierewicz B, Hasplova K, Huk A, Magdolenova Z, Miadokova E, et al. Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage. Food Chem Toxicol. 2012;50:3352-9 pubmed publisher
    ..In our study we have focused on quantitative analysis of Gentiana asclepiadea aqueous or methanolic extracts obtained from flower and haulm, their antioxidant potency in ABTS post-..
  11. Wang S, Xu Y, Jiang W, Zhang Y. Isolation and identification of constituents with activity of inhibiting nitric oxide production in RAW 264.7 macrophages from Gentiana triflora. Planta Med. 2013;79:680-6 pubmed publisher
    b>Gentiana triflora is widely used to treat inflammation, jaundice, hepatitis, and rheumatism...
  12. Imamura T, Higuchi A, Takahashi H. Dehydrins are highly expressed in overwintering buds and enhance drought and freezing tolerance in Gentiana triflora. Plant Sci. 2013;213:55-66 pubmed publisher
    ..Accumulation of GtDHNs may be part of the strategy for winter survival of gentian OWBs. ..
  13. Mishiba K, Nishihara M, Nakatsuka T, Abe Y, Hirano H, Yokoi T, et al. Consistent transcriptional silencing of 35S-driven transgenes in gentian. Plant J. 2005;44:541-56 pubmed
    In this study, no transgenic gentian (Gentiana triflora x Gentiana scabra) plants produced via Agrobacterium-mediated transformation exhibited transgene (GtMADS, gentian-derived MADS-box genes or sGFP, green fluorescent protein) ..
  14. Nakatsuka T, Nishihara M, Mishiba K, Hirano H, Yamamura S. Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. Mol Genet Genomics. 2006;275:231-41 pubmed
    Pink-flowered gentian plants (Gentiana scabra) have been bred from spontaneous mutations of blue-flowered gentian plants, but the formation mechanism(s) is unknown so far...
  15. Schmieder A, Schwaiger S, Csordas A, Backovic A, Messner B, Wick G, et al. Isogentisin--a novel compound for the prevention of smoking-caused endothelial injury. Atherosclerosis. 2007;194:317-25 pubmed
    ..Extracts from Gentiana lutea (Yellow Gentian) proved to be effective, and were therefore subjected to bio-guided fractionation...
  16. Kusar A, Zupancic A, Sentjurc M, Baricevic D. Free radical scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin resonance. Hum Exp Toxicol. 2006;25:599-604 pubmed
    Yellow gentian (Gentiana lutea L.) is a herbal species with a long-term use in traditional medicine due to its digestive and stomachic properties...
  17. Citová I, Ganzera M, Stuppner H, Solich P. Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis. J Sep Sci. 2008;31:195-200 pubmed
    ..electrophoresis method has been developed for the analysis of gentisin, isogentisin, and amarogentin in roots of Gentiana lutea (yellow gentian), an herb traditionally used as gastric stimulant...
  18. Wang A, Lian L, Jiang Y, Wu Y, Nan J. Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway. World J Gastroenterol. 2010;16:384-91 pubmed
    To investigate the in vivo hepatoprotective effects and mechanisms of Gentiana manshurica Kitagawa (GM) in acetaminophen (APAP)-induced liver injury in mice.
  19. Yang J, Liu L, Shi Y. Phytochemicals and biological activities of Gentiana species. Nat Prod Commun. 2010;5:649-64 pubmed
    b>Gentiana, a cosmopolitan and important genus of the Gentianaceae family, comprises over 300 species distributed among the world...
  20. Imamura T, Nakatsuka T, Higuchi A, Nishihara M, Takahashi H. The gentian orthologs of the FT/TFL1 gene family control floral initiation in Gentiana. Plant Cell Physiol. 2011;52:1031-41 pubmed publisher
    ..Thus, the negligible expression of GtTFL1 in early-flowering lines may be due to this insertion, resulting in a shortened vegetative stage...
  21. Kesavan R, Potunuru U, Nastasijevic B, T A, Joksic G, Dixit M. Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. PLoS ONE. 2013;8:e61393 pubmed publisher
    b>Gentiana lutea belonging to the Gentianaceae family of flowering plants are routinely used in traditional Serbian medicine for their beneficial gastro-intestinal and anti-inflammatory properties...
  22. Xu M, Wang D, Zhang Y, Yang C. Dammarane triterpenoids from the roots of Gentiana rigescens. J Nat Prod. 2007;70:880-3 pubmed
    Six new minor dammarane triterpenoids were isolated from the roots of Gentiana rigescens. These include one aglycone, gentirigenic acid (1), and five glycosides, gentirigeosides A-E (2-6)...
  23. Nakatsuka T, Haruta K, Pitaksutheepong C, Abe Y, Kakizaki Y, Yamamoto K, et al. Identification and characterization of R2R3-MYB and bHLH transcription factors regulating anthocyanin biosynthesis in gentian flowers. Plant Cell Physiol. 2008;49:1818-29 pubmed publisher
    ..These results strongly suggested that GtMYB3 and GtbHLH1 are involved in the regulation of gentiodelphin biosynthesis in gentian flowers...
  24. Menkovic N, Juranic Z, Stanojkovic T, Raonic Stevanovic T, Savikin K, Zdunic G, et al. Radioprotective activity of Gentiana lutea extract and mangiferin. Phytother Res. 2010;24:1693-6 pubmed publisher
    Radioprotective/sensitizing actions of Gentiana lutea aqueous-ethanol extract and mangiferin on radiation-induced effects on different types of cells were investigated...
  25. Mihailović V, Mihailovic M, Uskoković A, Arambasić J, Misić D, Stanković V, et al. Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol. 2013;52:83-90 pubmed publisher
    This study is an attempt to evaluate the hepatoprotective activity of Gentiana asclepiadea L. against carbon tetrachloride-induced liver injury in rats. Methanol extracts of aerial parts (GAA) and roots (GAR) of G...
  26. Wang Y, Xu M, Wang D, Yang C, Zeng Y, Zhang Y. Anti-inflammatory compounds of "Qin-Jiao", the roots of Gentiana dahurica (Gentianaceae). J Ethnopharmacol. 2013;147:341-8 pubmed publisher
    ..The root of Gentiana dahurica Fisch (Gentianaceae) is one of the four officially validated "Qin-Jiao" as listed in the ..
  27. Isakovic A, Jankovic T, Harhaji L, Kostic Rajacic S, Nikolic Z, Vajs V, et al. Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. Bioorg Med Chem. 2008;16:5683-94 pubmed publisher
    ..active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana...
  28. Fang Q, Zhan X, Mo J, Sun M. [Study rat nephrotoxicity of Longdan Xiegan Tang]. Zhongguo Zhong Yao Za Zhi. 2004;29:785-8 pubmed
    ..Longdan Xiegan Tang will result in injury of kidney function. ..
  29. Hou Q, Guo M, Zhang F, Zhou J, Liu L. [Callus cultivation and determination of gentiopicroside from Gentiana macrophylla]. Zhong Yao Cai. 2012;35:675-8 pubmed
    To explore and improve the utilization efficiency of Gentiana macrophylla resources...
  30. Yang H, Liu J, Chen S, Hu F, Zhou D. Spatial variation profiling of four phytochemical constituents in Gentiana straminea (Gentianaceae). J Nat Med. 2014;68:38-45 pubmed publisher
    b>Gentiana straminea is the famous Tibetan folk medicine thought to cure various diseases...
  31. Nakatsuka T, Saito M, Nishihara M. Functional characterization of duplicated B-class MADS-box genes in Japanese gentian. Plant Cell Rep. 2016;35:895-904 pubmed publisher
    ..isolated six B-class MADS-box genes (GsAP3a, GsAP3b, GsTM6, GsPI1, GsPI2, and GsPI3) from Japanese gentian (Gentiana scabra)...
  32. Wang C, Wang Z, Wang W, Peng X. [Advances in chemical components and pharmacology of genus Gentiana]. Zhongguo Zhong Yao Za Zhi. 2009;34:2987-94 pubmed
    The recent progresses on chemical components and pharmacological activities of the genus Gentiana were summarized. The main chemical constituents of this genus are iridoids, xanthone and flavone...
  33. Ni L, Zhao Z, Xu H, Chen S, Dorje G. The complete chloroplast genome of Gentiana straminea (Gentianaceae), an endemic species to the Sino-Himalayan subregion. Gene. 2016;577:281-8 pubmed publisher
    Endemic to the Sino-Himalayan subregion, the medicinal alpine plant Gentiana straminea is a threatened species. The genetic and molecular data about it is deficient. Here we report the complete chloroplast (cp) genome sequence of G...
  34. Yang Y, Wang Z, Zhang L, Yin B, Lv L, He J, et al. Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol-induced gastric mucosal injury in mice. Phytother Res. 2018;32:259-266 pubmed publisher
    Gentiopicroside isolated from gentiana macrophylla Pall. belongs to iridoid glycosides. This study aimed to evaluate the protective effect of gentiopicroside against ethanol-induced gastric mucosal injury in mice...
  35. Song B, Zhu J, Wang W, Hu G, Song X, Wang Z. [Quickly investigating the absorption ingredients of Gentianae Radix et Rhizoma by SEMAC]. Zhongguo Zhong Yao Za Zhi. 2012;37:969-73 pubmed
    ..SEMAC could be used as a tool to investigate the absorption ingredients of Gentianae Radix et Rhizoma. Drug in intestine sac was selective, and the absorption part of intestine was also different. ..
  36. Liu L, Zhang X, Wang L, Zhang Y. [Studies on plantlet regeneration and propagation of Gentiana stramines]. Zhongguo Zhong Yao Za Zhi. 2006;31:797-800 pubmed
    To provide scientific basis for large scale production by studying the technique of tissue culture of Gentiana stramines. Callus was induced from germ-free stem segment of G. stramines on a MS medium supplemented with different hormones...
  37. Suh H, Lee K, Kim K, Yang H, Choi E, Shin M, et al. A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse. J Ethnopharmacol. 2015;172:219-26 pubmed publisher
    b>Gentiana scabra root extract (GS) is frequently prescribed as an internal remedy in traditional Korean medicine for treatment of diabetes mellitus...
  38. Huang S, Agrawal D, Wu F, Tsay H. In vitro propagation of Gentiana scabra Bunge - an important medicinal plant in the Chinese system of medicines. Bot Stud. 2014;55:56 pubmed publisher
    b>Gentiana scabra Bunge commonly known as 'Long dan cao' in China has been used in traditional Chinese medicines for more than 2000 years...
  39. Wu Z, Zhao Y, Zhang J, Wang Y. Quality Assessment of Gentiana rigescens from Different Geographical Origins Using FT-IR Spectroscopy Combined with HPLC. Molecules. 2017;22: pubmed publisher
    i>Gentiana rigescens is a precious herbal medicine in China because of its liver-protective and choleretic effects. A method for the qualitative identification and quantitative evaluation of G...
  40. Balijagić J, Jankovic T, Zdunic G, Boskovic J, Savikin K, Godevac D, et al. Chemical profile, radical scavenging and cytotoxic activity of yellow gentian leaves (Genitaneae luteaefolium) grown in northern regions of Montenegro. Nat Prod Commun. 2012;7:1487-90 pubmed
    ..7 to 8.8 microg/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents. ..
  41. Olennikov D, Kashchenko N, Chirikova N, Tankhaeva L. Iridoids and Flavonoids of Four Siberian Gentians: Chemical Profile and Gastric Stimulatory Effect. Molecules. 2015;20:19172-88 pubmed publisher
    Some Gentiana species have been used by the nomadic people of Siberia as bitter teas or appetizers to eliminate digestive disorders (dyspepsia, heartburn, nausea, etc.). We studied the most frequently used gentians: Gentiana algida, G...
  42. Chu B, Zhang J, Li Z, Zhao Y, Zuo Z, Wang Y, et al. Evaluation and quantitative analysis of different growth periods of herb-arbor intercropping systems using HPLC and UV-vis methods coupled with chemometrics. J Nat Med. 2016;70:803-10 pubmed publisher
    ..with chemometrics for determination and qualitative evaluation of several kinds of intercropping system with Gentiana rigescens Franch. ex Hemsl. (GR), which is used as an hepatic protector in local communities in China...
  43. Mishiba K, Yamasaki S, Nakatsuka T, Abe Y, Daimon H, Oda M, et al. Strict de novo methylation of the 35S enhancer sequence in gentian. PLoS ONE. 2010;5:e9670 pubmed publisher
    A novel transgene silencing phenomenon was found in the ornamental plant, gentian (Gentiana triflora x G...
  44. Caetano Wyler S, Naciri Y. Evolutionary histories determine DNA barcoding success in vascular plants: seven case studies using intraspecific broad sampling of closely related species. BMC Evol Biol. 2016;16:103 pubmed publisher
    ..For Salix, Adenostyles, and Gentiana, the best results were obtained with the combination of matK, rpoB, and trnH-psbA...
  45. Shen T, Zhang J, Yang W, Yang M, Zhao Z, Zhang Z, et al. [Correlation and path analysis on agronomic traits of Gentiana rigescens]. Zhongguo Zhong Yao Za Zhi. 2011;36:1568-71 pubmed
    The interrelation of yield and agronomic traits of Gentiana rigescens was studied for the germplasm and breeding variety of this species...
  46. Pan Y, Zhang J, Shen T, Zhao Y, Zuo Z, Wang Y, et al. Investigation of chemical diversity in different parts and origins of ethnomedicine Gentiana rigescens Franch using targeted metabolite profiling and multivariate statistical analysis. Biomed Chromatogr. 2016;30:232-40 pubmed publisher
    b>Gentiana rigescens, an ethnomedicine, is widely cultivated in Yunnan province of China...
  47. Bianco A, Ramunno A, Melchioni C. Iridoids from seeds of Gentiana lutea. Nat Prod Res. 2003;17:221-4 pubmed
    In the seeds of Gentiana lutea L. there were also detected, in addition to the known sweroside and getiopicroside, loganic acid 3 and trifloroside 4 that is present as main glycosidic component...
  48. Du Z, Du T, Wang Z, Li G. [Study on extraction process of zhanjin ruji]. Zhongguo Zhong Yao Za Zhi. 2003;28:32-4 pubmed
    ..To select the optimum extraction process of Zhanjin Ruji...
  49. Mu Z, Yu Y, Gao H, Jiao W, Yao X. [Chemical and pharmacological research for Sect. Aptera (gentiana)]. Zhongguo Zhong Yao Za Zhi. 2009;34:2012-7 pubmed
    Sect. Aptera (Gentiana L.) is the plant origin of Traditional Chinese Medicine (TCM) "Qinjiao", which is used to treat rheumatism and pains with a long history. The plants of Sect...
  50. Wang L, Liu L, Wu D, An F. [Karyotype analysis of Gentiana straminea]. Zhong Yao Cai. 2010;33:171-3 pubmed
    Study on chromosome number, karyotype of Gentiana straminea for the first time. Compare karyotypes of Gentiana straminea, Gentiana macrophylla and Gentiana dahurica...
  51. Wei S, Chen G, He W, Chi H, Abe H, Yamashita K, et al. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. Phytother Res. 2012;26:168-73 pubmed publisher
    b>Gentiana straminea Maxim. has been used widely as a traditional Chinese medicine for the treatment of rheumarthritis, icterepatitis, constipation, pain and hypertension...
  52. Hudecova A, Hasplova K, Miadokova E, Magdolenova Z, Rinna A, Collins A, et al. Gentiana asclepiadea protects human cells against oxidation DNA lesions. Cell Biochem Funct. 2012;30:101-7 pubmed publisher
    ..objectives of this study were to examine whether the methanolic and aqueous extracts from the haulm and flower of Gentiana asclepiadea exhibited free radical scavenging and protective (antigenotoxic) effect against DNA oxidation induced ..
  53. Chen Q, Shi Z, Zhang Y, Zheng J. [Study on the chemical constituents in roots of Gentiana dahurica]. Zhong Yao Cai. 2011;34:1214-6 pubmed
    To systematically study the chemical constituents in the roots of Gentiana dahurica. Various column chromatographic techniques were used for isolation and purification...
  54. Jund R, Mondigler M, Steindl H, Stammer H, Stierna P, Bachert C. Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis. Rhinology. 2012;50:417-26 pubmed publisher
    ..A herbal drug combination (Dry Extract BNO 1016) has been assessed for efficacy and tolerability in patients with acute viral rhinosinusitis...
  55. Patenkovic A, Stamenkovic Radak M, Nikolić D, Marković T, Anđelković M. Synergistic effect of Gentiana lutea L. on methyl methanesulfonate genotoxicity in the Drosophila wing spot test. J Ethnopharmacol. 2013;146:632-6 pubmed publisher
    b>Gentiana lutea L...
  56. Wang C, Cheng X, Bligh S, White K, Branford White C, Wang Z. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. J Pharm Biomed Anal. 2007;44:1113-7 pubmed
    ..0+/-13.9 microgh/ml (DG), 32.7+/-12.9 microgh/ml (GPS) and 19.1+/-5.9 microgh/ml (LXT). The study demonstrates the marked variability in pharmacokinetics and bioavailability of an active component from different herbal preparations. ..
  57. Jankovic T, Krstić Milosević D, Aljancić I, Savikin K, Menkovic N, Radanović D, et al. Phytochemical re-investigation of Gentiana utriculosa. Nat Prod Res. 2009;23:466-9 pubmed publisher
    ..with 1,3,7,8-oxidation pattern and flavone isoorientin-3'-O-glucoside were isolated from the aerial parts of Gentiana utriculosa. Xanthone-C-glucoside lancerin was detected in Gentiana species for the first time...
  58. Hikage T, Kogusuri K, Tanaka Saito C, Watanabe S, Chiba S, Kume K, et al. W14/15 esterase gene haplotype can be a genetic landmark of cultivars and species of the genus Gentiana L. Mol Genet Genomics. 2011;285:47-56 pubmed publisher
    ..This gene encodes closely related but not identical proteins W14 and W15 that accumulate in overwinter buds of Gentiana triflora (Takahashi et al. in Breed Sci 56:39-46, 2006; Hikage et al. in Mol Genet Genomics 278:95-104, 2007)...
  59. Hudecova A, Hasplova K, Miadokova E, Magdolenova Z, Rinna A, Galova E, et al. Cytotoxic and genotoxic effect of methanolic flower extract from Gentiana asclepiadea on COS 1 cells. Neuro Endocrinol Lett. 2010;31 Suppl 2:21-5 pubmed
    The purpose of this study was to assess whether a methanol extract isolated from the flower of Gentiana asclepiadea had potential cytotoxic or genotoxic effect on COS 1 (monkey kidney) cell line...
  60. Jin L, Liu J, Zhang Y, Zhu T, Chen H. [Cryopreservation and plantlet regeneration of dormant buds of Gentiana straminea by vitrification]. Zhong Yao Cai. 2012;35:1374-7 pubmed
    To investigate the detailed techniques for cryopreservation of Gentiana straminea dormant buds by vitrification. Dormant buds as an experimental material,the influence of the different size of dormant buds,preculture and PVS etc...
  61. Mirzaee F, Hosseini A, Jouybari H, Davoodi A, Azadbakht M. Medicinal, biological and phytochemical properties of Gentiana species. J Tradit Complement Med. 2017;7:400-408 pubmed publisher
    b>Gentiana, a cosmopolitan and important genus of the Gentianaceae family, comprises 400 species distributed among the world...
  62. Wang X, Sun H, Sun H, Wu X. [Influence of gentian leaf blight on the output and quality of Chinese gentian]. Zhongguo Zhong Yao Za Zhi. 2004;29:734-6 pubmed
    ..The loss of output and the drop of quality are relatively heavy when the disease is serious. The loss of income is not obvious when the index of disease is under 60. ..
  63. Nie Y, Lin P. [Determination of five active constituents in aerial part of Tibetan medicine Gentiana straminea by HPLC]. Zhongguo Zhong Yao Za Zhi. 2010;35:1276-9 pubmed
    ..constituents, including loganic acid, swertiamarin, gentiopicroside, sweroside, isoorientin in aerial part of Gentiana straminea. Analysis was achieved on a Hypersil ODS analytical column (4...
  64. Jiang Z, Liu H, Liu X, Shang J, Zhao J, Yuan C. Chemical constituents of Gentiana macrophylla Pall. Nat Prod Res. 2010;24:1365-9 pubmed publisher
    ..dimeric secoiridoid glucoside, gentimacroside (1), and six known compounds (2-7) were isolated from the roots of Gentiana macrophylla Pall...
  65. Aberham A, Pieri V, Croom E, Ellmerer E, Stuppner H. Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC-MS and RP-HPLC. J Pharm Biomed Anal. 2011;54:517-25 pubmed publisher
    ..for the simultaneous determination of bioactive compounds in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea...
  66. García V, Bermejo J, Rubio S, Quintana J, Estevez F. Pregnane steroidal glycosides and their cytostatic activities. Glycobiology. 2011;21:619-24 pubmed publisher
    ..With respect to the compounds containing only the steroid ring (6-8), the presence of a charged O-amino-benzoyl but not a tigloyl group improved the cytotoxicity. ..
  67. Yamasaki S, Oda M, Daimon H, Mitsukuri K, Johkan M, Nakatsuka T, et al. Epigenetic modifications of the 35S promoter in cultured gentian cells. Plant Sci. 2011;180:612-9 pubmed publisher
    ..The de novo methylation status was also resistant to 5-aza-2'-deoxycytidine treatment. These results suggest that de novo methylation of the enhancer region is a primitive process of 35S silencing that triggers histone H3 deacetylation. ..
  68. Ruan J, Zheng C, Liu Y, Qu L, Yu H, Han L, et al. Chemical and Biological Research on Herbal Medicines Rich in Xanthones. Molecules. 2017;22: pubmed publisher
    ..Among them, Calophyllum, Cratoxylum, Cudrania, Garcinia, Gentiana, Hypericum and Swertia genera are plant resources with great development prospect...
  69. Jia M, Sun W, Guo Z. [Power X-ray diffraction analysis of Chinese medicinal materials Radix Gentianae macrophyllae]. Zhong Yao Cai. 2003;26:168-70 pubmed
    ..And X-ray diffraction figure may be used as one fingerprint method for Chinese herbal medicine...
  70. Urbain A, Marston A, Queiroz E, Ndjoko K, Hostettmann K. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004;70:1011-4 pubmed
    ..The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity...
  71. Kropf M, Comes H, Kadereit J. Long-distance dispersal vs vicariance: the origin and genetic diversity of alpine plants in the Spanish Sierra Nevada. New Phytol. 2006;172:169-84 pubmed
    ..In Kernera saxatilis, Silene rupestris and Gentiana alpina we found intraspecific phylogroups corresponding to mountain regions as predicted by the vicariance ..
  72. Liu H, Liu H, Xue J, Zheng Y, Chen F, Zhang B. [Study on safe use of 10% difenoconazole in GAP of Gentiana scabra]. Zhongguo Zhong Yao Za Zhi. 2008;33:2096-8 pubmed
    To investigate the safe use of 10% difenoconazole in planting Gentiana scabra.
  73. Fürst M, Nash D. Host ant independent oviposition in the parasitic butterfly Maculinea alcon. Biol Lett. 2010;6:174-6 pubmed publisher
    ..alcon. Matched potted Gentiana plants were set out close to host-ant nests and non-host-ant nests, and the number and position of eggs attached ..
  74. Glatthaar Saalmüller B, Rauchhaus U, Rode S, Haunschild J, Saalmuller A. Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections. Phytomedicine. 2011;19:1-7 pubmed publisher
    ..Our results demonstrate that Sinupret(®) shows a broad spectrum of antiviral activity in vitro against viruses commonly known to cause respiratory infections...
  75. Tang Z, Peng M, Zhan C. [Screening 20 Chinese herbs often used for clearing heat and dissipating toxin with nude mice model of hepatitis C viral infection]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23:447-8 pubmed
    ..To seek effective drugs for anti-hepatitis C virus by screening 20 Chinese herbs often used for clearing heat and dissipating toxin with nude mice model of hepatitis C viral (HCV) infection...
  76. Kumar V, Chand R, Auzi A, Ikeshiro Y, Sarker S. 2'-(2,3-Dihydroxybenzoyloxy)-7-ketologanin: a novel iridoid glucoside from the leaves of Gentiana kurroo. Pharmazie. 2003;58:668-70 pubmed
    ..acylated iridoid glucoside, 2'-(2,3-dihydroxybenzoyloxy)-7-ketologanin (1), has been isolated from the leaves of Gentiana kurroo...
  77. Wang C, Wang Z, Bligh S, White K, White C. Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. Eur J Drug Metab Pharmacokinet. 2004;29:199-203 pubmed
    The pharmacokinetics and tissue distribution of Gentiopicroside (GPS), one of the major active components of the Gentiana species of medicinal plants, was studied following oral and intravenous administration in mice...
  78. Matsukawa K, Ogata M, Hikage T, Minami H, Shimotai Y, Saitoh Y, et al. Antiproliferative activity of root extract from gentian plant (Gentiana triflora) on cultured and implanted tumor cells. Biosci Biotechnol Biochem. 2006;70:1046-8 pubmed
    ..Root extract from Gentiana triflora triggered cell death of human Daudi cells in culture...
  79. Zhou D, Hou Q, Si Q, Liu J, Yang H. Concentrations of the active constituents of the Tibetan folk medicine Qinjiao (Gentiana sect. Cruciata) within and between taxonomic species across the Qinghai-Tibetan Plateau. Chem Biodivers. 2010;7:2088-94 pubmed publisher
    ..The traditional crude medicine Qinjiao is derived from the dried roots of three species belonging to Gentiana sect. Cruciata (Gentianaceae) growing in the Qinghai-Tibetan Plateau (QTP)...
  80. Liang X, Tian Q, Wei Z, Liu F, Chen J, Zhao Y, et al. Effect of Feining on bleomycin-induced pulmonary injuries in rats. J Ethnopharmacol. 2011;134:971-6 pubmed publisher
    The flowers of Gentiana veitchiorum has been widely used in decoction form in the traditional medicine of Tibet against tussis, tracheitis, angina for their anti-inflammatory, antimicrobial and alexipharmic properties.
  81. Zhang J, Yuan T, Wang Y, Zhao Y, Zhang J, Jin H. Determination of mineral elements in Gentiana rigescens from different zones of Yunnan, China. Biol Trace Elem Res. 2012;147:329-33 pubmed publisher
    The concentrations of nine mineral elements were determined by atomic absorption spectroscopy in Gentiana rigescens from three zones (middle, southeast, and northwest zones) of Yunnan province in China...
  82. Zhang Y, Zhang G, Xu X, Zhang M, Qu D, Niu H, et al. Suppression of growth of A549 lung cancer cells by waltonitone and its mechanisms of action. Oncol Rep. 2012;28:1029-35 pubmed publisher
    ..Waltonitone can be applied to lung carcinoma as a chemotherapeutic candidate...
  83. Zhu C, Yamamura S, Nishihara M, Koiwa H, Sandmann G. cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development. Biochim Biophys Acta. 2003;1625:305-8 pubmed
    ..epsilon -cyclase, lycopene beta-cyclase, beta-carotene hydroxylase and zeaxanthin epoxidase were isolated from a Gentiana lutea petal cDNA library. The function of all cDNAs was analyzed by complementation in Escherichia coli...
  84. Xue C, Li D, Wang Q. Identification and quantification of the traditional Chinese medicinal plant Gentiana macrophylla using Taqman real-time PCR. Planta Med. 2008;74:1842-5 pubmed publisher
    b>Gentiana macrophylla Pall. is a commonly used antirheumatic herb. There are four species of Gentiana recorded as herbal drugs in the Chinese Pharmacopoeia. The other species are often marketed as G...
  85. Chen L, Chen Q, Xu D, Hao J, Schlappi M, Xu Z. Changes of gentiopicroside synthesis during somatic embryogenesis in Gentiana macrophylla. Planta Med. 2009;75:1618-24 pubmed publisher
    IN VITRO plant regeneration of Gentiana macrophylla Pall. and determination of gentiopicroside content during somatic embryogenesis are described in the present work...
  86. Luo K, Ma P, Yao H, Xin T, Hu Y, Zheng S, et al. [Identification of gentianae macrophyllae radix using the ITS2 barcodes]. Yao Xue Xue Bao. 2012;47:1710-7 pubmed
    ..Based on the established method, we successfully identified two samples of Gentianae Macrophyllae Radix bought in pharmacy to the original species...
  87. Nakatsuka T, Yamada E, Saito M, Fujita K, Nishihara M. Heterologous expression of gentian MYB1R transcription factors suppresses anthocyanin pigmentation in tobacco flowers. Plant Cell Rep. 2013;32:1925-37 pubmed publisher
    ..These genes should consequently be useful for manipulating anthocyanin accumulation via genetic engineering in flowers of other floricultural plant species...
  88. Mel nyk V, Spiridonova K, Andrieiev I, Strashniuk N, Kunakh V. [The investigation of genomes of some species of the genus Gentiana in nature and in vitro cell culture]. Tsitol Genet. 2002;36:28-34 pubmed
    The comparative study of the genomes of intact plants-representatives of some species of the genus Gentiana L. as well as cultured cells of G. lutea and G. punctata was performed using restriction analysis...
  89. Kakuda R, Machida K, Yaoita Y, Kikuchi M, Kikuchi M. Studies on the constituents of Gentiana species. II. A new triterpenoid, and (S)-(+)- and (R)-(-)-gentiolactones from Gentiana lutea. Chem Pharm Bull (Tokyo). 2003;51:885-7 pubmed
    ..triterpenoid, 12-ursene-3beta, 11alpha-diol 3-O-palmitate (1), has been isolated from the rhizomes and roots of Gentiana lutea, together with the artificial diene derivative, 9 (11), 12-ursadien-3beta-ol 3-O-palmitate (1a) and five ..
  90. Vinckier S, Smets E. Morphological and ultrastructural diversity of orbicules in Gentianaceae. Ann Bot. 2003;92:657-72 pubmed
    ..l.; however, they seem not to be useful for tribal delimitation in Gentianaceae. In the tribes Potalieae and Gentianeae orbicule data may be useful at subtribal level...
  91. Xu Z, Gao H, Ou Yang K, Cai S, Hu Y. Establishment of a cell-based assay to screen regulators for Klotho gene promoter. Acta Pharmacol Sin. 2004;25:1165-70 pubmed
    ..Recombinant Klotho protein improves age-associated diseases in animal models. It has been proposed that up-regulation of Klotho gene expression may have anti-aging effects...
  92. Haraguchi H, Tanaka Y, Kabbash A, Fujioka T, Ishizu T, Yagi A. Monoamine oxidase inhibitors from Gentiana lutea. Phytochemistry. 2004;65:2255-60 pubmed
    Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea...