vinca

Summary

Summary: A plant genus of the family Apocynaceae.

Top Publications

  1. Mori S, Kobayashi H, Hoshi Y, Kondo M, Nakano M. Heterologous expression of the flavonoid 3',5'-hydroxylase gene of Vinca major alters flower color in transgenic Petunia hybrida. Plant Cell Rep. 2004;22:415-21 pubmed
    ..A full-length cDNA for the F3'5'H gene was cloned from petals of Vinca major, and its genomic clone, designated VmFH1 (accession number AB078781 in the GenBank/EMBL/DDBJ databases), was ..
  2. Aldaghi M, Massart S, Roussel S, Steyer S, Lateur M, Jijakli M. Comparison of different techniques for inoculation of "Candidatus Phytoplasma mali" on apple and periwinkle in biological indexing procedure. Commun Agric Appl Biol Sci. 2007;72:779-84 pubmed
    ..Moreover, the latency period before symptom observation was longer. Finally, we perceived the apple trees are more convenient and rapid than periwinkle plants for biological indexing of apple materials. ..
  3. Yin H, Sun Y. Vincamine-producing endophytic fungus isolated from Vinca minor. Phytomedicine. 2011;18:802-5 pubmed publisher
    b>Vinca minor is a plant containing the alkaloid vincamine, which is used in the pharmaceutical industry as a cerebral stimulant and vasodilator. The objective of this study was to determine whether endophytic fungi isolated from V...
  4. Hasa D, Perissutti B, Dalĺ Acqua S, Chierotti M, Gobetto R, Grabnar I, et al. Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer. Eur J Pharm Biopharm. 2013;84:138-44 pubmed publisher
    ..In this paper, the oral bioavailability of vincamine when administered as a standardised Vinca minor L. leaf dry extract rather than pure indole alkaloid is demonstrated to be higher...
  5. Neuss M, Gilmore T, Belderson K, Billett A, Conti Kalchik T, Harvey B, et al. 2016 Updated American Society of Clinical Oncology/Oncology Nursing Society Chemotherapy Administration Safety Standards, Including Standards for Pediatric Oncology. J Oncol Pract. 2016;12:1262-1271 pubmed
    ..new standards: most notably, two-person verification of chemotherapy preparation processes, administration of vinca alkaloids via minibags in facilities in which intrathecal medications are administered, and labeling of ..
  6. Sriussadaporn C, Yamamoto K, Fukushi K, Simazaki D. Comparison of DNA damage detected by plant comet assay in roadside and non-roadside environments. Mutat Res. 2003;541:31-44 pubmed
    ..in selected plant biomonitors, which were ginkgo (Ginkgo biloba), pohtos (Epipremnum aureum), and periwinkle (Vinca rosea), setting in roadside and non-roadside environments...
  7. Boiko N, Medrano G, Montano E, Jiang N, Williams C, Madungwe N, et al. TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids. PLoS ONE. 2017;12:e0186888 pubmed publisher
    Chemotherapy induced peripheral neuropathy (CIPN), a side effect of many anti-cancer drugs including the vinca alkaloids, is characterized by a severe pain syndrome that compromises treatment in many patients...
  8. Levrier C, Sadowski M, Rockstroh A, Gabrielli B, Kavallaris M, Lehman M, et al. 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells. Mol Cancer Ther. 2017;16:3-15 pubmed publisher
    ..Yet, microtubule alterations that are associated with resistance to microtubule-destabilizing drugs like vinca alkaloids (vinblastine/vincristine) or 2-methoxyestradiol did not confer resistance to 6-AA, suggesting a ..
  9. Kong P, Richardson P, Hong C. Direct colony PCR-SSCP for detection of multiple pythiaceous oomycetes in environmental samples. J Microbiol Methods. 2005;61:25-32 pubmed
    ..Application of this technique for disease diagnosis and monitoring pathogen sources was explored, and the potential for studying diversity and population dynamics of other cultivated microbial communities in the environment is discussed...

More Information

Publications62

  1. Pandya P, Gupta S, Pandav K, Barthwal R, Jayaram B, KUMAR S. DNA binding studies of Vinca alkaloids: experimental and computational evidence. Nat Prod Commun. 2012;7:305-9 pubmed
    ..The proton resonances of a DNA decamer duplex were assigned. The models of the drug:DNA complexes were analyzed for DNA binding features. The effect of temperature on the DNA binding was also evaluated. ..
  2. Dumontet C. [Antitubulin agents]. Bull Cancer. 2011;98:1275-85 pubmed publisher
    ..There are currently a variety of available vinca alkaloids and taxanes and other agents, such as ixabepilone and eribulin, have also been approved...
  3. Haque N, Salma U, Nurunnabi T, Uddin M, Jahangir M, Islam S, et al. Management of type 2 diabetes mellitus by lifestyle, diet and medicinal plants. Pak J Biol Sci. 2011;14:13-24 pubmed
    ..In this article we have tried to describe how diet and lifestyle with using medicinal plants may help to prevent or maintain diabetes and help to reduce the mortality and morbidity due to diabetes or complication related to it. ..
  4. Chen J, Pu X, Deng X, Liu S, Li H, Civerolo E. A phytoplasma related to 'Candidatus phytoplasma asteri' detected in citrus showing Huanglongbing (yellow shoot disease) symptoms in Guangdong, P. R. China. Phytopathology. 2009;99:236-42 pubmed publisher
    ..In contrast, walled bacteria were at low titer. This study showed that in addition to 'Ca. L. asiaticus', a phytoplasma related to 'Ca. P. asteri' could also be detected in citrus showing HLB symptoms in Guangdong...
  5. Sáez Calvo G, Sharma A, Balaguer F, Barasoain I, Rodríguez Salarichs J, Olieric N, et al. Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Cell Chem Biol. 2017;24:737-750.e6 pubmed publisher
    ..Our results establish TPs as vinca-site microtubule-stabilizing agents that promote longitudinal tubulin contacts in microtubules, in contrast to ..
  6. Mercado Matos J, Clark J, Piper A, Janusis J, Shaw L. Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells. J Biol Chem. 2017;292:7806-7816 pubmed publisher
    ..sensitizes breast carcinoma cells to apoptosis in response to treatment with microtubule-disrupting drugs, identifying IRS-2 as a potential biomarker for the response of breast cancer patients to Vinca alkaloid drug treatment.
  7. Cioroiu C, Weimer L. Update on Chemotherapy-Induced Peripheral Neuropathy. Curr Neurol Neurosci Rep. 2017;17:47 pubmed publisher
    ..Advances regarding established classes including taxanes, platins, and vinca alkaloids are also reviewed. CIPN is an important often dose-limiting toxicity...
  8. Khan W, Ahmad S, Yasin N, Ali A, Ahmad A, Akram W. Application of Bacillus megaterium MCR-8 improved phytoextraction and stress alleviation of nickel in Vinca rosea. Int J Phytoremediation. 2017;19:813-824 pubmed publisher
    ..research was performed to evaluate the effect of Bacillus megaterium MCR-8 on mitigation of nickel (Ni) stress in Vinca rosea grown on Ni-contaminated soil (50, 100, and 200 mg Ni kg-1 soil)...
  9. De O, Chatterji B. Marine Derived Anticancer Drugs Targeting Microtubule. Recent Pat Anticancer Drug Discov. 2017;12:102-127 pubmed publisher
    ..Microtubule targeting agents (MTAs) such as the vinca alkaloids or taxanes, although are effective for cancer therapy, have adverse side effects...
  10. Aldaghi M, Massart S, Roussel S, Jijakli M. Establishment of a new method for rapid and precise estimation of apple proliferation phytoplasma concentration in periwinkle. Commun Agric Appl Biol Sci. 2006;71:853-7 pubmed
    ..This work is a preliminary step to study the interaction of phytoplasmas with their hosts in relation to symptoms expression. ..
  11. Siampour M, Izadpanah K, Marzachì C, Salehi Abarkoohi M. Identification and characterization of conserved and variable regions of lime witches' broom phytoplasma genome. Microbiology. 2015;161:1741-51 pubmed publisher
    ..Some of these genes are expected to have been involved in the development of features specific to LWB phytoplasma. ..
  12. Herrmann J, Yang E, Iliescu C, Cilingiroglu M, Charitakis K, Hakeem A, et al. Vascular Toxicities of Cancer Therapies: The Old and the New--An Evolving Avenue. Circulation. 2016;133:1272-89 pubmed publisher
    ..Classical chemotherapeutic agents such as cisplatin, often used in combination with bleomycin and vinca alkaloids, can lead to vascular events including acute coronary thrombosis and may be associated with an increased ..
  13. Levac D, Cázares P, Yu F, De Luca V. A Picrinine N-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids. Plant Physiol. 2016;170:1935-44 pubmed publisher
    ..similarity to γ-tocopherol C-methyltransferases was used in a bioinformatic screen of transcriptomes from Vinca minor, Rauvolfia serpentina, and C...
  14. Waight A, Bargsten K, Doronina S, Steinmetz M, Sussman D, Prota A. Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. PLoS ONE. 2016;11:e0160890 pubmed publisher
    ..Moreover, we illustrate how peptidic vinca-site agents carrying terminal carboxylate residues may exploit an observed extended hydrogen bond network with the ..
  15. Mohamed S, Jantan I, Haque M. Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action. Int Immunopharmacol. 2017;50:291-304 pubmed publisher
    ..action of various immunomodulators such as polyphenolic compounds, flavonoids, organosulfur compounds, capsaicin, vinca alkaloids, bromelain, betulinic acid and zerumbone, the affected cancerous cell lines in addition to the targeted ..
  16. Borowiak M, Nahaboo W, Reynders M, Nekolla K, Jalinot P, Hasserodt J, et al. Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death. Cell. 2015;162:403-411 pubmed publisher
    Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca alkaloids, are widely used in cell biology research and as clinical anticancer drugs...
  17. Li H, Sun L, Li H, Lv X, Semukunzi H, Li R, et al. DT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small-cell lung cancer cells. Cell Death Dis. 2017;8:e2810 pubmed publisher
    ..Vinorelbine (NVB), a semi-synthetic vinca alkaloid, is used for advanced and metastatic NSCLC by destabilizing microtubule formation to induce mitotic ..
  18. Ghosh D, Roy I, Chanda S, Gupta Bhattacharya S. Allergy to periwinkle pollen (Catharanthus roseus G. Don.). Ann Agric Environ Med. 2007;14:39-43 pubmed
    ..It can be concluded that CR pollen can trigger IgEmediated respiratory allergy in the people living in close proximity. ..
  19. Szaflarski W, Fay M, Kedersha N, Zabel M, Anderson P, Ivanov P. Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation. Oncotarget. 2016;7:30307-22 pubmed publisher
    ..We show that the vinca alkaloid (VA) class of anti-neoplastic agents potently activates a SG-mediated stress response program...
  20. Saba N, Seal A. Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5. J Mol Model. 2018;24:82 pubmed publisher
    b>Vinca alkaloids are chemotherapeutic agents used in the treatment of both pediatric and adult cancer patients. Cytochrome P450 3A5 (CYP3A5) is 9- to 14-fold more efficient at clearing vincristine than cytochrome P450 3A4 (CYP3A4) is...
  21. de Souza A, Takita M, Coletta Filho H, Caldana C, Goldman G, Yanai G, et al. Analysis of gene expression in two growth states of Xylella fastidiosa and its relationship with pathogenicity. Mol Plant Microbe Interact. 2003;16:867-75 pubmed
    ..This report represents the first study of the transcriptome of this pathogen, which has recently gained more importance, since the genome of several strains has been either partially or entirely sequenced. ..
  22. Yurkovetskiy A, Yin M, Bodyak N, Stevenson C, Thomas J, Hammond C, et al. A Polymer-Based Antibody-Vinca Drug Conjugate Platform: Characterization and Preclinical Efficacy. Cancer Res. 2015;75:3365-72 pubmed publisher
    ..Using trastuzumab and a vinca drug derivative to demonstrate the utility of this platform, a novel Fleximer-based ADC was prepared and ..
  23. Takara K, Sakaeda T, Yagami T, Kobayashi H, Ohmoto N, Horinouchi M, et al. Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines. Biol Pharm Bull. 2002;25:771-8 pubmed
    ..The relative resistance to vinca-alkaloids was 300- to 600,000-fold, and HvrlOO-6 cells showed the highest relative resistance to vinorelbine...
  24. Yadav A, Sharma S, Yadav V. Non-covalent carriage of anticancer agents by humanized antibody trastuzumab. J Mol Model. 2016;22:112 pubmed publisher
    This article explores the internalization and non-covalent carriage of small molecule anticancer agents like vinca alkaloids by humanized monoclonal antibody trastuzumab...
  25. Wang Y, Xing Y, Chen L, Meng T, Li Y, Xie J, et al. Fluconazole versus mould-active triazoles for primary antifungal prophylaxis in adult patients with acute lymphoblastic leukemia: clinical outcome and cost-effectiveness analysis. Int J Hematol. 2018;107:235-243 pubmed publisher
    ..to fluconazole as the first-line prophylactic for adult patients with ALL accompanied by uncommon severe vinca alkaloid-induced neurotoxicity...
  26. Van den Broeck H, De Wolf H, Backeljau T, Blust R. Effect of metal accumulation on metallothionein level and condition of the periwinkle Littorina littorea along the Scheldt estuary (the Netherlands). Environ Pollut. 2010;158:1791-9 pubmed publisher
    ..Cd, Cu and Zn) and fitness indicators (i.e. MT and condition data) was examined using a canonical correlation analysis. Periwinkles with a high metal load (i.e. Cd and Zn) also had high MT levels but were in a relatively poor condition. ..
  27. Wei X, Khan A, Song D, Dai Z, Liu Y, Yu H, et al. Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan. Nat Prod Bioprospect. 2017;7:323-327 pubmed publisher
    ..vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data...
  28. Perry E, Howes M. Medicinal plants and dementia therapy: herbal hopes for brain aging?. CNS Neurosci Ther. 2011;17:683-98 pubmed publisher
  29. Banach M, Juranek J, Zygulska A. Chemotherapy-induced neuropathies-a growing problem for patients and health care providers. Brain Behav. 2017;7:e00558 pubmed publisher
    ..The three most neurotoxic classes of anti-cancer drugs are: platinum-based drugs, taxanes, and thalidomide and its analogs; other, less neurotoxic but also commonly used drugs are: bortezomib, ixabepilone, and vinca alkaloids.
  30. Monfort S, Pan X, Patrick R, Ramaswamy B, Wesolowski R, Naughton M, et al. Gait, balance, and patient-reported outcomes during taxane-based chemotherapy in early-stage breast cancer patients. Breast Cancer Res Treat. 2017;164:69-77 pubmed publisher
    ..neuropathy (CIPN) is a dose-limiting toxicity of several commonly used chemotherapy drugs including taxanes, vinca alkaloids, and platinum compounds...
  31. Streckmann F, Balke M, Lehmann H, Rustler V, Koliamitra C, Elter T, et al. The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP. BMC Cancer. 2018;18:62 pubmed publisher
    ..controlled clinical trial involving 236 oncological patients receiving either oxaliplatin (N?=?118) or vinca-alkaloid (N?=?118) who are randomized to one of two interventions (SMT or WBV) or a treatment as usual (TAU) group...
  32. Abouzeid S, Beutling U, Surup F, Abdel Bar F, Amer M, Badria F, et al. Treatment of Vinca minor Leaves with Methyl Jasmonate Extensively Alters the Pattern and Composition of Indole Alkaloids. J Nat Prod. 2017;80:2905-2909 pubmed publisher
    Alkaloids extracted from mature Vinca minor leaves were fractionated by preparative HPLC. By means of HRMS and NMR data, the main alkaloids were identified as vincamine, strictamine, 10-hydroxycathofoline, and vincadifformine...
  33. Huang S, Tang R, Poon R. BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death. Oncotarget. 2016;7:38718-38730 pubmed publisher
    Microtubule inhibitors including taxanes and vinca alkaloids are among the most widely used anticancer agents. Disrupting the microtubules activates the spindle-assembly checkpoint and traps cells in mitosis...
  34. Yang Y, Guo Y, Tan X, He H, Zhang Y, Yin T, et al. Vincristine-loaded liposomes prepared by ion-paring techniques: Effect of lipid, pH and antioxidant on chemical stability. Eur J Pharm Sci. 2018;111:104-112 pubmed publisher
    ..by ion-pairing techniques and the model could be applied to investigate the effect of lipids on the degradation of vinca alkaloids, and how to weaken their influence by adjusting pH and adding antioxidants...
  35. Mavroeidis L, Sheldon H, Briasoulis E, Marselos M, Pappas P, Harris A. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Int J Oncol. 2015;47:455-64 pubmed publisher
    ..Vinorelbine is an orally bioavailable vinca alkaloid shown to be useable for metronomic administration...
  36. Kashiwagi S, Fukushima W, Asano Y, Goto W, Takada K, Noda S, et al. Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer. BMC Cancer. 2017;17:604 pubmed publisher
    ..eribulin), is a microtubule dynamics inhibitor with a mechanism of action that differs from those of taxanes and vinca alkaloids...
  37. Berho N, Duret S, Danet J, Renaudin J. Plasmid pSci6 from Spiroplasma citri GII-3 confers insect transmissibility to the non-transmissible strain S. citri 44. Microbiology. 2006;152:2703-16 pubmed
    ..citri strain 44. This is believed to be the first report of a phenotypic change associated with transformation of S. citri by natural plasmids...
  38. D Acquarica I, Ghirga F, Quaglio D, Cerreto A, Ingallina C, Tafi A, et al. Molecular Recognition of Natural Products by Resorc[4]arene Receptors. Curr Pharm Des. 2016;22:1715-29 pubmed
    ..towards a series of natural products, namely amino acids, amphetamine, ethanolamine neurotransmitters, dipeptides, vinca alkaloids and nucleosides...
  39. Berho N, Duret S, Renaudin J. Absence of plasmids encoding adhesion-related proteins in non-insect-transmissible strains of Spiroplasma citri. Microbiology. 2006;152:873-86 pubmed
    ..Whether plasmid-encoded genes are involved in transmission of S. citri by its leafhopper vector remains to be determined...
  40. Chakrabarti R, Patankar S. Combination Assays and Molecular Docking can Identify Binding sites of Anti-Microtubule Drugs on Plasmodium falciparum Tubulin. Infect Disord Drug Targets. 2016;16:204-216 pubmed
    ..It is important to define the binding sites of these molecules on the tubulin dimer: Taxol, Vinca domains or novel binding pockets; however, extraction of native parasite tubulin is difficult...
  41. Corbitt N, Malick L, Nishioka J, Rigdon A, Szoch S, Torr P. Instituting Vincristine Minibag Administration: An Innovative Strategy Using Simulation to Enhance Chemotherapy Safety. J Infus Nurs. 2017;40:346-352 pubmed publisher
    The first fatal incident of wrong-route administration of vinca alkaloids occurred in 1968. Initial recommendations for practice change occurred in 2005. In 2012, 54% of oncology treatment sites had changed their practice...
  42. Valluri J. Bioreactor production of secondary metabolites from cell cultures of periwinkle and sandalwood. Methods Mol Biol. 2009;547:325-35 pubmed publisher
    ..The exploitation of variant cell strains and biotransformation of added precursors can certainly improve the use of periwinkle and sandalwood cell cultures for the bioproduction of desired compounds...
  43. Nanjappa S, Snyder M, Greene J. Vancomycin Infiltrate-Induced Dermatitis Mimicking Bullous Cellulitis. J Drugs Dermatol. 2017;16:1160-1163 pubmed
    ..Well-known vesicants like anthracyclines, vinca alkaloids, and vasopressors are usually administered with proper caution...
  44. Wang Y, Melzer R, Theissen G. A double-flowered variety of lesser periwinkle (Vinca minor fl. pl.) that has persisted in the wild for more than 160 years. Ann Bot. 2011;107:1445-52 pubmed publisher
    ..We therefore investigated a double-flowered variety of lesser periwinkle, Vinca minor flore pleno (fl. pl.), that is reported to have existed in the wild for at least 160 years...
  45. Bianco A, Guiso M, Nicoletti M, Foddai S, Piccin A, Serafini M, et al. A comparative chemotaxonomic study on Vinca sardoa steam and Vinca difformis pourret. Nat Prod Res. 2005;19:615-7 pubmed
    The phytochemical analysis of iridoidic fraction of the aerial parts of Vinca sardoa and Vinca difformis, gave the identification of loganic acid in V. difformis as unique iridoid glucoside, while loganin is also present in V. sardoa...
  46. Vaidyanathan G, Zalutsky M. Imaging drug resistance with radiolabeled molecules. Curr Pharm Des. 2004;10:2965-79 pubmed
    ..Multidrug resistance (MDR) is often seen with chemotherapeutic agents such as anthracycline derivatives, vinca alkaloids and taxanes. Multiple aspects of cellular biochemistry have been implicated in the MDR process...
  47. Caserta R, Takita M, Targon M, Rosselli Murai L, de Souza A, Peroni L, et al. Expression of Xylella fastidiosa fimbrial and afimbrial proteins during biofilm formation. Appl Environ Microbiol. 2010;76:4250-9 pubmed publisher
    ..The proteins were also detected in bacteria colonizing the xylem vessels of infected plants...
  48. Chiu L, Hsin I, Yang T, Sung W, Chi J, Chang J, et al. The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Oncogene. 2017;36:242-253 pubmed publisher
    ..data indicate that pemetrexed resistance could be relieved by non-cross-resistant chemotherapeutic drugs such as vinca alkaloids and might be independent to TP53 status...
  49. Mills C, Kolb E, Sampson V. Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer. Cancer Res. 2017;77:6489-6498 pubmed publisher
    ..abemaciclib), aurora kinases (AT9283 and MLN8237), Wee1 kinase (MK-1775), KSP (ispinesib), and tubulin (taxanes, vinca alkaloids), are presented...
  50. Kulkarni R, Baskaran K. From herkogamy to cleistogamy--development of cleistogamy in periwinkle. J Hered. 2013;104:140-8 pubmed publisher
    ..This appears to be the first report on the development of cleistogamous plants in an allogamous species. ..
  51. Bhagat J, Kaur A, Kaur R, Yadav A, Sharma V, Chadha B. Cholinesterase inhibitor (Altenuene) from an endophytic fungus Alternaria alternata: optimization, purification and characterization. J Appl Microbiol. 2016;121:1015-25 pubmed publisher
    The aim of this study was to screen endophytic fungi isolated from Vinca rosea for their potential to produce acetylcholinesterase (AChE) inhibitors. Endophytic fungi isolated from V...
  52. Pierro J, Krick E, Flory A, Regan R, DeRegis C, Boudreaux B, et al. Febrile neutropenia in cats treated with chemotherapy. Vet Comp Oncol. 2017;15:550-556 pubmed publisher
    ..A total of 22 FN events in 20 cats were evaluated. Lymphoma was the most common cancer diagnosis; lomustine and vinca alkaloids were the most frequently implicated causative agents...
  53. Liu Z, Wu H, Li Y, Gu H, Yin X, Xie L, et al. Rapid and simultaneous determination of five vinca alkaloids in Catharanthus roseus and human serum using trilinear component modeling of liquid chromatography-diode array detection data. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1026:114-123 pubmed publisher
    ..The average recoveries of five vinca alkaloids ranged from 97.1% to 101.9% and 98.8% to 103.0% in C. roseus and human serum samples, respectively...