tylophora

Summary

Summary: A plant genus of the family ASCLEPIADACEAE. Members contain phenanthro-indolizidine alkaloids.

Top Publications

  1. Cui L, Abliz Z, Xia M, Zhao L, Gao S, He W, et al. On-line identification of phenanthroindolizidine alkaloids in a crude extract from Tylophora atrofolliculata by liquid chromatography combined with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18:184-90 pubmed
    ..LC/MS(n)) were applied to identify trace-level phenanthroindolizidine alkaloids in crude extracts from Tylophora atrofolliculata...
  2. Huang X, Gao S, Fan L, Yu S, Liang X. Cytotoxic alkaloids from the roots of Tylophora atrofolliculata. Planta Med. 2004;70:441-5 pubmed
    ..three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence...
  3. Saraswati S, Kanaujia P, Kumar S, Kumar R, Alhaider A. Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis. Mol Cancer. 2013;12:82 pubmed publisher
    ..Tylophorine exerts anti-angiogenesis effects via VEGFR2 signaling pathway thus, may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies. ..
  4. Yang C, Lee Y, Hsu H, Wu C, Chang H, Chao Y, et al. c-Jun-mediated anticancer mechanisms of tylophorine. Carcinogenesis. 2013;34:1304-14 pubmed publisher
    Tylophorine, a phenanthroindolizidine alkaloid, is the major medicinal constituent of herb Tylophora indica. Tylophorine treatment increased the accumulation of c-Jun protein, a component of activator protein 1 (AP1), in carcinoma cells...
  5. Stoye A, Peez T, Opatz T. Left, right, or both? On the configuration of the phenanthroindolizidine alkaloid tylophorine from Tylophora indica. J Nat Prod. 2013;76:275-8 pubmed publisher
    The alkaloid (-)-tylophorine was isolated from a sample of Tylophora indica, and the crude extract was analyzed by HPLC/MS(n) and chiral HPLC/MS...
  6. Lee Y, Huang C, Yang C, Hsu H, Kang I, Chao Y, et al. Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the Formosan Tylophora ovata. Planta Med. 2011;77:1932-8 pubmed publisher
    An investigation of alkaloids present in the leaves and stems of Tylophora ovata led to the isolation of two new septicine alkaloids and one new phenanthroindolizidine alkaloid, tylophovatines A, B, C (1, 2, and 5), respectively, ..
  7. Yao S, Tang C, Ye Y. Secoiridoids and xanthones from Tylophora secamonoides Tsiang. J Asian Nat Prod Res. 2008;10:591-6 pubmed publisher
    ..glycoside, secamonoide B (2), together with nine known compounds, were isolated from the aerial parts of Tylophora secamonoides Tsiang. Their structures were elucidated on the basis of spectroscopic methods...
  8. Ganguly T, Khar A. Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome c and activation of caspase 3. Phytomedicine. 2002;9:288-95 pubmed
    b>Tylophora alkaloids are plant products known for their antiasthamatic and antiproliferative activities. The underlying cellular changes resulting from inhibition of proliferation were investigated...
  9. Gantait S, Kundu S. Neoteric trends in tissue culture-mediated biotechnology of Indian ipecac [Tylophora indica (Burm. f.) Merrill]. 3 Biotech. 2017;7:231 pubmed publisher
    b>Tylophora indica (Burm. f.) Merrill, an ethno-pharmacologically important perennial climber of Asclepiadaceae, is commonly known as Antamul or Indian ipecac...

More Information

Publications23

  1. Liu Z, Lv H, Li H, Zhang Y, Zhang H, Su F, et al. Interaction studies of an anticancer alkaloid, (+)-(13aS)-deoxytylophorinine, with calf thymus DNA and four repeated double-helical DNAs. Chemotherapy. 2011;57:310-20 pubmed publisher
    ..13aS)-deoxytylophorinine is a new phenanthroindolizidine alkaloid originally extracted from the roots of Tylophora atrofolliculata and Tylophora ovata in our institute...
  2. Chaudhuri K, Das S, Bandyopadhyay M, Zalar A, Kollmann A, Jha S, et al. Transgenic mimicry of pathogen attack stimulates growth and secondary metabolite accumulation. Transgenic Res. 2009;18:121-34 pubmed publisher
    ..sepium, W. somnifera and Tylophora tanakae...
  3. Chaudhuri K, Ghosh B, Tepfer D, Jha S. Genetic transformation of Tylophora indica with Agrobacterium rhizogenes A4: growth and tylophorine productivity in different transformed root clones. Plant Cell Rep. 2005;24:25-35 pubmed
    We have developed an efficient transformation system for Tylophora indica, an important medicinal plant in India, using Agrobacterium rhizogenes strains LBA9402 and A4 to infect excised leaf and stem explants and intact shoots at ..
  4. Sharafkhaneh A, Velamuri S, Badmaev V, Lan C, Hanania N. The potential role of natural agents in treatment of airway inflammation. Ther Adv Respir Dis. 2007;1:105-20 pubmed publisher
    ..This review provides an overview of the literature related to the anti-inflammatory effects of some of the natural agents which have potential value in the treatment of inflammatory lung diseases...
  5. Thomas D. [Effect of sugars, gibberellic acid and abscisic acid on somatic embryogenesis in Tylophora indica (Burm. f.) Merrill]. Sheng Wu Gong Cheng Xue Bao. 2006;22:465-71 pubmed
    ..acid (GA3) and abscisic acid (ABA) on somatic embryogenesis from internodal explant-derived callus of Tylophora indica (Burm. f.) Merrill has been investigated...
  6. Dhiman M, Parab R, Manju S, Desai D, Mahajan G. Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine. Nat Prod Commun. 2012;7:1171-2 pubmed
    ..alkaloids, tylophorinidine hydrochloride (TdnH) and tylophorinine hydrochloride (TnnH), isolated from the plant Tylophora indica (local name, Antamul) was evaluated...
  7. Ali N. Brine shrimp cytotoxicity of crude methanol extract and antispasmodic activity of ?-amyrin acetate from Tylophora hirsuta wall. BMC Complement Altern Med. 2013;13:135 pubmed publisher
    We have previously reported that aerial parts of Tylophora hirsuta have antispasmodic profile. The current work is an attempt for isolation of pharmacologically active compound(s) that contribute for its antispasmodic activity...
  8. Chaudhuri K, Ghosh B, Jha S. The root: a potential new source of competent cells for high-frequency regeneration in Tylophora indica. Plant Cell Rep. 2004;22:731-40 pubmed
    The purpose of this study was to develop a new micropropagation system for Tylophora indica, an important medicinal plant in India, using root explants as starting material...
  9. Teixeira da Silva J, Jha S. Micropropagation and genetic transformation of Tylophora indica (Burm. f.) Merr.: a review. Plant Cell Rep. 2016;35:2207-2225 pubmed
    This review provides an in-depth and comprehensive overview of the in vitro culture of Tylophora species, which have medicinal properties. Tylophora indica (Burm. f.) Merr. is a climbing perennial vine with medicinal properties...
  10. Huang X, Yu S, Liang X, Li N. A novel steroid from Tylophora atrofolliculata Metc. J Asian Nat Prod Res. 2002;4:197-200 pubmed
    A novel steroid, tylophoriside A, was isolated from Tylophora atrofolliculata Metc. The structure was elucidated on the basis of spectroscopic methods and X-ray diffraction.
  11. Yang C, Lee Y, Kang I, Barnard D, Jan J, Lin D, et al. Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus. Antiviral Res. 2010;88:160-8 pubmed publisher
    ..7%) in rats. Thus, our results suggest that tylophorine compounds are novel and potent anti-coronavirus agents that may be developed into therapeutic agents for treating TGEV or SARS CoV infection. ..
  12. Liu Z, Lv H, Li H, Zhang Y, Zhang H, Su F, et al. Anticancer effect and neurotoxicity of S-(+)-deoxytylophorinidine, a new phenanthroindolizidine alkaloid that interacts with nucleic acids. J Asian Nat Prod Res. 2011;13:400-8 pubmed publisher
    ..CAT) is a new phenanthroindolizidine alkaloid, originally extracted from the roots of Tylophora atrofolliculata and Tylophora ovata. Potent anticancer activity was observed in vitro and in vivo...
  13. Gao W, Chen A, Leung C, Gullen E, Fürstner A, Shi Q, et al. Structural analogs of tylophora alkaloids may not be functional analogs. Bioorg Med Chem Lett. 2008;18:704-9 pubmed
    Phenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity...
  14. Chaudhuri K, Ghosh B, Tepfer D, Jha S. Spontaneous plant regeneration in transformed roots and calli from Tylophora indica: Changes in morphological phenotype and tylophorine accumulation associated with transformation by Agrobacterium rhizogenes. Plant Cell Rep. 2006;25:1059-66 pubmed
    ..rhizogenes on the production of tylophorine, a phenanthroindolizidine alkaloid, in the Indian medicinal plant, Tylophora indica...