Summary: A plant genus of the family APOCYNACEAE. It is a very poisonous plant that contains cardioactive agents.

Top Publications

  1. Adome R, Gachihi J, Onegi B, Tamale J, Apio S. The cardiotonic effect of the crude ethanolic extract of Nerium oleander in the isolated guinea pig hearts. Afr Health Sci. 2003;3:77-82 pubmed
    ..One such herb of interest is Nerium oleander...
  2. Turan N, Akgun Dar K, Kuruca S, Kılıcaslan Ayna T, Seyhan V, Atasever B, et al. Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect. J Exp Ther Oncol. 2006;6:31-8 pubmed
    b>Nerium oleander (No), is a toxic plant. In recent studies, it was determined that the extracts of this plant are effective to treat some types of cancer, but these studies are limited and do not include human leukemia...
  3. Sharma P, Mohan L, Srivastava C. Larvicidal potential of Nerium indicum and Thuja oriertelis extracts against malaria and Japanese encephalitis vector. J Environ Biol. 2005;26:657-60 pubmed
    Ethanolic and acetone extracts of Nerium indicum and Thuja orientelis have been studied against III instar larvae of Anopheles stephensi and Culex quinquefasciatus. Ethanolic extract of N...
  4. Smith P, Aldridge B, Kittleson M. Oleander toxicosis in a donkey. J Vet Intern Med. 2003;17:111-4 pubmed
  5. Aslani M, Movassaghi A, Mohri M, Abbasian A, Zarehpour M. Clinical and pathological aspects of experimental oleander (Nerium oleander) toxicosis in sheep. Vet Res Commun. 2004;28:609-16 pubmed
    Dried Nerium oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to six native male sheep...
  6. Rashan L, Franke K, Khine M, Kelter G, Fiebig H, Neumann J, et al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011;134:781-8 pubmed publisher
    ..Asclepiadaceae) and from Nerium oleander L. (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin...
  7. Bandara V, Weinstein S, White J, Eddleston M. A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning. Toxicon. 2010;56:273-81 pubmed publisher
    b>Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) are potentially lethal plants after ingestion...
  8. Bai L, Zhao M, Toki A, Sakai J, Yang X, Bai Y, et al. Three new cardenolides from methanol extract of stems and twigs of Nerium oleander. Chem Pharm Bull (Tokyo). 2010;58:1088-92 pubmed
    Two new cardenolide monoglycosides, cardenolides B-1 (1) and B-2 (2) were isolated from Nerium oleander, together with oleagenin (3) which is the first isolated compound from natural sources...
  9. Ibrahim A, Khalifa S, Khafagi I, Youssef D, Khan S, Mesbah M, et al. Microbial metabolism of biologically active secondary metabolites from Nerium oleander L. Chem Pharm Bull (Tokyo). 2008;56:1253-8 pubmed
    Ursolic acid (1) and kaempferol (3) are two major constituents of the Mediterranean plant Nerium oleander L...

More Information


  1. Wang H, Cai W, Wang W, Yang J. Molluscicidal activity of Nerium indicum Mill, Pterocarya stenoptera DC, and Rumex japonicum houtt on Oncomelania hupensis. Biomed Environ Sci. 2006;19:245-8 pubmed
    ..To evaluate the molluscicidal activities of three Chinese plants N. indicum Mill, R stenoptera DC, and R. japonicum Houtt, and to clarify the molluscicidal mechanism...
  2. Zhao M, Bai L, Wang L, Toki A, Hasegawa T, Kikuchi M, et al. Bioactive cardenolides from the stems and twigs of Nerium oleander. J Nat Prod. 2007;70:1098-103 pubmed
    Four new cardenolide monoglycosides, cardenolides N-1 (1), N-2 (2), N-3 (3), and N-4 (4), were isolated from Nerium oleander, together with two known cardenolides, 5 and 12, and seven cardenolide monoglycosides, 6-11 and 13...
  3. Calderón Montaño J, Burgos Morón E, Orta M, Mateos S, López Lázaro M. A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells. Planta Med. 2013;79:1017-23 pubmed publisher
    Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional medicine for treating several disorders including cancer, and extracts from the ..
  4. Hughes K, Dart A, Hodgson D. Suspected Nerium oleander (Oleander) poisoning in a horse. Aust Vet J. 2002;80:412-5 pubmed
  5. Bai L, Wang L, Zhao M, Toki A, Hasegawa T, Ogura H, et al. Bioactive pregnanes from Nerium oleander. J Nat Prod. 2007;70:14-8 pubmed
    ..2), and 16beta,17beta-epoxy-12beta-hydroxypregna-4,6-diene-3,20-dione (3), were isolated from Nerium oleander, together with two known compounds, 12beta-hydroxypregna-4,6,16-triene-3,20-dione (neridienone A, 4) and ..
  6. Smesrud J, Benson C, Albright W, Richards J, Wright S, Israel T, et al. Using pilot test data to refine an alternative cover design in northern California. Int J Phytoremediation. 2012;14 Suppl 1:76-93 pubmed
    ..This finding underscores the importance of establishing and maintaining the appropriate vegetation on ET covers in this climate...
  7. Domínguez Fuentes B, Romero Palacios A, García Gil D, López Alvaro J. [Nerium oleander poisoning]. Rev Clin Esp. 2007;207:537 pubmed
  8. Alaimo M, Colombo P, Firetto A, Trapani S, Vizzì D, Melati M. Stress-induced injuries and trace element concentrations in vascular leaf plants from an urban environment (Palermo, Italy). J Trace Elem Med Biol. 2003;17 Suppl 1:65-74 pubmed
    ..Samples were collected at various sites in different periods. ..
  9. Botelho A, Santos Miranda A, Joca H, Mattoso C, de Oliveira M, Pierezan F, et al. Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity. J Ethnopharmacol. 2017;206:170-177 pubmed publisher
    b>Nerium oleander L. (OLE) has been used medicinally and is reported to possess a wide range of pharmacological activities. OLE effects are caused by different cardiac glycosides (CG), primarily oleandrin, found within the plant...
  10. Blua M, Redak R, Morgan D, Costa H. Seasonal flight activity of two Homalodisca species (Homoptera: Cicadellidae) that spread Xylella fastidiosa in southern California. J Econ Entomol. 2001;94:1506-10 pubmed
    ..Likewise, H. lacerta in Riverside was more associated with citrus than oleander, yet H. lacerta in Palm Desert was trapped in greater numbers in oleander than citrus. ..
  11. Dasgupta A, Kang E, Datta P. The new enzyme-linked immunosorbent digoxin assay on the ADVIA Integrated Modular System is virtually free from oleander interference. Ther Drug Monit. 2006;28:282-5 pubmed
    ..However, we observed no statistically significant change in digoxin concentration when ECLIA digoxin assay was used, indicating that this assay is virtually free from oleander interference. ..
  12. Marín Casino M, Arce Casas A, Martinez Roig A, Mateu de Antonio J. [Diagnosis of Nerium oleander poisoning: is a single analytical method enough?]. Farm Hosp. 2007;31:257-8; author reply 259 pubmed
  13. Dong Q, Liu X, Yao J, Dong X, Ma C, Xu Y, et al. Structural characterization of a pectic polysaccharide from Nerium indicum flowers. Phytochemistry. 2010;71:1430-7 pubmed publisher
    A polysaccharide fraction, J6, was isolated from the hot-water extract of flowers of oleander Nerium indicum Mill...
  14. Rossini Oliva S, Mingorance M. Assessment of airborne heavy metal pollution by aboveground plant parts. Chemosphere. 2006;65:177-82 pubmed
    Italian stone pine (Pinus pinea L.) and oleander (Nerium oleander L...
  15. Zhao M, Zhang S, Fu L, Li N, Bai J, Sakai J, et al. Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities. J Nat Prod. 2006;69:1164-7 pubmed
    ..1) and 20beta,28-epoxytaraxaster-21-en-3beta-ol (2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type triterpenes, 28-nor-urs-12-ene-3beta,17beta-diol (3) and 3beta-hydroxyurs-12-..
  16. Tiwari S, Singh A. Control of common freshwater predatory fish, Channa punctatus, through Nerium indicum leaf extracts. Chemosphere. 2003;53:865-75 pubmed
    The diethyl ether, chloroform, acetone and methanol extract of Nerium indicum leaf were evaluated for their piscicidal activity against common freshwater air breathing predatory fish Channa punctatus...
  17. Downer J, Craigmill A, Holstege D. Toxic potential of oleander derived compost and vegetables grown with oleander soil amendments. Vet Hum Toxicol. 2003;45:219-21 pubmed
    ..Soil from oleander mulched and amended plots contained low levels of oleandrin at the time of harvest. ..
  18. Arao T, Fuke C, Takaesu H, Nakamoto M, Morinaga Y, Miyazaki T. Simultaneous determination of cardenolides by sonic spray ionization liquid chromatography-ion trap mass spectrometry--a fatal case of oleander poisoning. J Anal Toxicol. 2002;26:222-7 pubmed
    ..In order to make identification of oleandrin reliable, LC-MS-MS analysis was performed. The concentrations of oleandrin found in the heart blood and cerebrospinal fluid were 9.8 and 10.1 ng/mL, respectively. ..
  19. Arriola Martínez P, Montero Aparicio E, Martinez Odriozola P, Miguel de la Villa F. [Toxicity due to oleander (Nerium oleander) ingestion]. Med Clin (Barc). 2006;127:759 pubmed
  20. Harrison J, Mondor E. Evidence for an invasive aphid "superclone": extremely low genetic diversity in Oleander aphid (Aphis nerii) populations in the southern United States. PLoS ONE. 2011;6:e17524 pubmed publisher
    ..Feeding primarily on Oleander (Nerium oleander) and Milkweed (Asclepias spp...
  21. Badet F, Hennequin A, Khouatra C, Soulier V, Fournier G, Costedoat Chalumeau N. [We don't beat around the bush anymore]]. Rev Med Interne. 2005;26 Suppl 2:S197-9 pubmed
  22. Cochis A, Fracchia L, Martinotti M, Rimondini L. Biosurfactants prevent in vitro Candida albicans biofilm formation on resins and silicon materials for prosthetic devices. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:755-61 pubmed publisher
    ..concentrations of biosurfactants obtained from endophyte biofilms selected from Robinia pseudoacacia and from Nerium oleander, and afterward infected with C. albicans cells...
  23. Soto Blanco B, Fontenele Neto J, Silva D, Reis P, Nóbrega J. Acute cattle intoxication from Nerium oleander pods. Trop Anim Health Prod. 2006;38:451-4 pubmed
    Seven outbreaks of acute intoxication from oleander (Nerium oleander) in cattle were reported in Northeast of Brazil. A total of 92 cattle were poisoned by oleander in 7 different herds; 57 animals died (67% of affected cattle)...
  24. Dongarrà G, Sabatino G, Triscari M, Varrica D. The effects of anthropogenic particulate emissions on roadway dust and Nerium oleander leaves in Messina (Sicily, Italy). J Environ Monit. 2003;5:766-73 pubmed
    Complementary studies on the inorganic chemical composition of Nerium oleander leaves collected in the town of Messina (Sicily, Italy) and seven grain-size fractions of local roadway dust have been carried out...
  25. Shinde P, Vidyasagar N, Dhulap S, Dhulap A, Hirwani R. Natural Products based P-glycoprotein Activators for Improved ?-amyloid Clearance in Alzheimer's Disease: An in silico Approach. Cent Nerv Syst Agents Med Chem. 2015;16:50-9 pubmed
    ..Since ancient time medicinal plants such as Withania somnifera, Bacopa monieri, Nerium indicum have been used to prevent neurological disorders including Alzheimer's disease...
  26. Gayathri V, Ananthi S, Chandronitha C, Sangeetha M, Vasanthi H. Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats. Nat Prod Res. 2011;25:1110-4 pubmed publisher
    b>Nerium oleander Linn. (NO), an evergreen shrub, is used in folklore medicine as a cardiotonic and exhibits a wide spectrum of bioactivities...
  27. Raichand R, Kaur I, Singh N, Mayilraj S. Pontibacter rhizosphera sp. nov., isolated from rhizosphere soil of an Indian medicinal plant Nerium indicum. Antonie Van Leeuwenhoek. 2011;100:129-35 pubmed publisher
    ..pigmented bacterium was isolated from a soil sample collected from the rhizosphere of an Indian medicinal plant, Nerium indicum (Chuvanna arali) and subjected to a detailed polyphasic taxonomic study...
  28. Ten Bosch L, Kohler R, Ortmann R, Wieneke S, Viöl W. Insecticidal Effects of Plasma Treated Water. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..Mealybugs growing on Nerium oleander have been treated using PTW after being transferred to Petri dishes, thus avoiding possible buffering ..
  29. Huang Q. Specific detection and identification of Xylella fastidiosa strains causing oleander leaf scorch using polymerase chain reaction. Curr Microbiol. 2009;58:393-8 pubmed publisher
    ..fastidiosa, especially in locations where mixed natural infections by oleander and other strains of X. fastidiosa occur. ..
  30. Lo Gullo M, Glatzel G, Devkota M, Raimondo F, Trifilò P, Richter H. Mistletoes and mutant albino shoots on woody plants as mineral nutrient traps. Ann Bot. 2012;109:1101-9 pubmed publisher
    ..Here it is hypothesized that mutant albino shoots on otherwise green plants should behave similarly, because they lack photosynthesis and thus cannot recycle elements involved in sugar loading...
  31. Franco A, Rufo L, Zuluaga J, de la Fuente V. Metal uptake and distribution in cultured seedlings of Nerium oleander L. (Apocynaceae) from the Río Tinto (Huelva, Spain). Biol Trace Elem Res. 2013;155:82-92 pubmed publisher
    b>Nerium oleander L. (Apocynaceae) is a micro-nano phanerophyte that grows in the riverbanks of the Río Tinto basin (Southwest Iberian Peninsula)...
  32. Yamauchi K, Yasuda S, Hamada K, Tsutsumi Y, Fukushima K. Multiform biosynthetic pathway of syringyl lignin in angiosperms. Planta. 2003;216:496-501 pubmed
    ..oleander ( Nerium indicum Mill.), magnolia ( Magnolia kobus DC.) and Arabidopsis thaliana (L.) Heynh...
  33. Bai Y, Huo Y, Liao K, Qu J. Influence of microbial community diversity and function on pollutant removal in ecological wastewater treatment. Appl Microbiol Biotechnol. 2017;101:7293-7302 pubmed publisher
    ..of microbes aggregate in the plant rhizosphere and the sludge under plant roots, we selected two plant species (Nerium oleander and Arundo donax) to study the characteristics of rhizosphere and sludge microbes...
  34. Benitez E, Paredes D, Rodriguez E, Aldana D, Gonzalez M, Nogales R, et al. Bottom-up effects on herbivore-induced plant defences: a case study based on compositional patterns of rhizosphere microbial communities. Sci Rep. 2017;7:6251 pubmed publisher
    ..We implemented a regulated system comprising Nerium oleander plants grown in soil initially containing a sterile/non sterile inoculum, herbivore Aphis nerii and ..
  35. Cerboneschi M, Decorosi F, Biancalani C, Ortenzi M, Macconi S, Giovannetti L, et al. Indole-3-acetic acid in plant-pathogen interactions: a key molecule for in planta bacterial virulence and fitness. Res Microbiol. 2016;167:774-787 pubmed publisher
    ..savastanoi pv. nerii were produced. Pathogenicity tests using the host plant Nerium oleander showed that ?iaaL and ?iaaM were hypervirulent and hypovirulent, respectively and these features appeared ..
  36. Dyer S. Plant exposures: wilderness medicine. Emerg Med Clin North Am. 2004;22:299-313, vii pubmed
    ..This article discusses poisonous plants, the symptoms that might arise if they are ingested, and the treatments that should be administered to patients...
  37. Renier A, Kass P, Magdesian K, Madigan J, Aleman M, Pusterla N. Oleander toxicosis in equids: 30 cases (1995-2010). J Am Vet Med Assoc. 2013;242:540-9 pubmed publisher
    ..To determine clinical, laboratory analysis, and necropsy findings for equids with oleander toxicosis and to identify factors associated with outcome...
  38. Banerjee A, Vasu K, Pancholi H, Rajani M, Nivsarkar M. Detoxification of Nerium indicum roots based on Indian system of medicine: phytochemical and toxicity evaluations. Acta Pol Pharm. 2011;68:905-11 pubmed
    ..b>Nerium indicum is traditionally used as a medicine though known to cause severe allergic symptoms, tachycardia and ..
  39. Juurlink D, Sivilotti M. Multidose activated charcoal for yellow oleander poisoning. Lancet. 2003;362:581; author reply 581 pubmed
  40. Chondrogiannis C, Grammatikopoulos G. Photosynthesis in developing leaf of juveniles and adults of three Mediterranean species with different growth forms. Photosynth Res. 2016;130:427-444 pubmed
    ..prereproductive individuals) and adults (fully reproductive individuals) of an evergreen sclerophyllous shrub (Nerium oleander), a semi-deciduous dimorphic shrub (Phlomis fruticosa), and a winter deciduous tree with pre-leafing ..
  41. Abdolzadeh A, Shima K, Lambers H, Chiba K. Change in uptake, transport and accumulation of ions in Nerium oleander (rosebay) as affected by different nitrogen sources and salinity. Ann Bot. 2008;102:735-46 pubmed publisher
    ..In this study, the effects of NaCl on net uptake, accumulation and transport of ions were investigated in Nerium oleander with ammonium or nitrate as the nitrogen source in order to analyse differences in uptake and cycling of ..
  42. Siddiqui B, Khatoon N, Begum S, Durrani S. Two new triterpenoid isomers from Nerium oleander leaves. Nat Prod Res. 2009;23:1603-8 pubmed publisher
    ..isomers alpha-neriursate (1) and beta-neriursate (2) have been isolated from the fresh, uncrushed leaves of Nerium oleander and their structures elucidated as 3alpha-acetophenoxy-urs-12-en-28-oic acid and 3beta-acetophenoxy-urs-..
  43. Wang X, Li G, Zheng L, Ji K, Lu H, Liu F, et al. Nematicidal cardenolides from Nerium indicum Mill. Chem Biodivers. 2009;6:431-6 pubmed publisher
    Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation...
  44. SantaCruz Calvo L, Gonzalez Lopez J, Manzanera M. Arthrobacter siccitolerans sp. nov., a highly desiccation-tolerant, xeroprotectant-producing strain isolated from dry soil. Int J Syst Evol Microbiol. 2013;63:4174-80 pubmed publisher
    A novel desiccation-tolerant, xeroprotectant-producing bacterium, designated strain 4J27(T), was isolated from a Nerium oleander rhizosphere subjected to seasonal drought in Granada, Spain...
  45. Saravanan K, Senthilkumar S, Elayaraja M, Suresh B. Toxicity of Nerium indicum Miller seed extract on bandicoot rat, Bandicota bengalensis Gray. Indian J Exp Biol. 2004;42:1003-6 pubmed
    ..Crude extract (12.5 ml/kg) of N. indicum seed gave 100% mortality of B. bengalensis. Humanness assessment study revealed that this plant orgin chemical caused low pain and sufferings to the target pests. ..
  46. Karageorgou P, Tziortzis I, Manetas Y. Are saturating pulses indeed saturating? Evidence for considerable PSII yield underestimation in leaves adapted to high levels of natural light. J Plant Physiol. 2007;164:1331-6 pubmed
    ..The possible reasons for the apparent inability of "saturating" pulses to close all PSII centers at high actinic light and the practical implications, especially in field work, are discussed. ..
  47. Dey P, Dutta S, Biswas Raha A, Sarkar M, Chaudhuri T. Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study. BMC Complement Altern Med. 2016;16:280 pubmed publisher
    b>Nerium oleander L. (syn. Nerium indicum Mill, Nerium odorum Aiton) belongs to the family Apocynaceae. It is used for its anti-inflammatory, anti-diabetic, anti-cancer and hepatoprotective activities in traditional medicine...
  48. Papi L, Luciani A, Forni D, Giusiani M. Unexpected double lethal oleander poisoning. Am J Forensic Med Pathol. 2012;33:93-7 pubmed publisher
    b>Nerium oleander is a very popular urban ornamental plant in Europe, but it is also extremely dangerous because it contains several types of glycosides, accidental ingestion of which can cause cardiac arrhythmias and even deaths...
  49. Omidi A, Razavizadeh A, Movassaghi A, Aslani M. Experimental oleander (Nerium oleander) intoxication in broiler chickens (Gallus gallus). Hum Exp Toxicol. 2012;31:853-8 pubmed publisher
    ..The lack of information about the toxicity of oleanders in poultry was the main cause for this study. The results suggest that chickens appear to respond to oleander poisoning in a manner similar to other species. ..
  50. Poindexter B, Feng W, Dasgupta A, Bick R. Oleandrin produces changes in intracellular calcium levels in isolated cardiomyocytes: a real-time fluorescence imaging study comparing adult to neonatal cardiomyocytes. J Toxicol Environ Health A. 2007;70:568-74 pubmed
    ..6.1.3], and/or dysfunction of sarcolemmal calcium release channels. ..
  51. Zhao M, Bai L, Toki A, Hasegawa R, Sakai J, Hasegawa T, et al. The structure of a new cardenolide diglycoside and the biological activities of eleven cardenolide diglycosides from Nerium oleander. Chem Pharm Bull (Tokyo). 2011;59:371-7 pubmed
    A new cardenolide diglycoside (1) was isolated from Nerium oleander together with ten known cardenolide diglycosides 2-11. The structure of compound 1 was established on the basis of their spectroscopic data...
  52. Wojtyna W, Enseleit F. A rare cause of complete heart block after transdermal botanical treatment for psoriasis. Pacing Clin Electrophysiol. 2004;27:1686-8 pubmed
    ..implantation of a definitive DDDR pacemaker, the patient reported a transdermal self-medication with an extract of Nerium oleander for the treatment of his psoriasis...
  53. Mwafy S, Yassin M. Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model. Pak J Biol Sci. 2011;14:984-90 pubmed
    The present study is aimed to assess the therapeutic potential of sulfonylurea drug glimepiride in comparison with Nerium oleander plant extract on insulin, glucose levels and some liver enzymes activities in streptozotocin-induced ..