catharanthus

Summary

Summary: A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.

Top Publications

  1. Dutta A, Batra J, Pandey Rai S, Singh D, Kumar S, Sen J. Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don. Planta. 2005;220:376-83 pubmed
    Madagascar periwinkle, Catharanthus roseus (L.) G...
  2. Levac D, Murata J, Kim W, De Luca V. Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase. Plant J. 2008;53:225-36 pubmed
    The Madagascar periwinkle (Catharanthus roseus) produces the well-known and remarkably complex anti-cancer dimeric alkaloids vinblastine and vincristine that are derived from the coupling of vindoline and catharanthine monomers...
  3. Liscombe D, O Connor S. A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus. Phytochemistry. 2011;72:1969-77 pubmed publisher
    ..vindoline and catharanthine, monoterpenoid indole alkaloids produced exclusively by the Madagascar periwinkle (Catharanthus roseus). Industrial production of vinblastine and vincristine currently relies on isolation from C...
  4. Lacava P, Li W, Araujo W, Azevedo J, Hartung J. The endophyte Curtobacterium flaccumfaciens reduces symptoms caused by Xylella fastidiosa in Catharanthus roseus. J Microbiol. 2007;45:388-93 pubmed
    ..fastidiosa. Periwinkle is considered to be an excellent experimental system by which the interaction of C. flaccumfaciens and other endophytic bacteria with X. fastidiosa can be studied...
  5. Guirimand G, Burlat V, Oudin A, Lanoue A, St Pierre B, Courdavault V. Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase. Plant Cell Rep. 2009;28:1215-34 pubmed publisher
    The monoterpene indole alkaloids (MIA) synthesized in Catharanthus roseus are highly valuable metabolites due to their pharmacological properties...
  6. Yang S, Kim S, Kim Y, Kim H, Chun Y, Choi H. Metabolic discrimination of Catharanthus roseus calli according to their relative locations using (1)H-NMR and principal component analysis. Biosci Biotechnol Biochem. 2009;73:2032-6 pubmed
    ..In this study, inner and outer cells of Catharanthus roseus with various elicitors in solid-state cultures were differentiated by (1)H NMR (nuclear magnetic ..
  7. Montiel G, Zarei A, Körbes A, Memelink J. The jasmonate-responsive element from the ORCA3 promoter from Catharanthus roseus is active in Arabidopsis and is controlled by the transcription factor AtMYC2. Plant Cell Physiol. 2011;52:578-87 pubmed publisher
    ..In Catharanthus roseus, the ethylene response factor (ERF) transcription factor ORCA3 controls the jasmonate-responsive ..
  8. Tikhomiroff C, Jolicoeur M. Screening of Catharanthus roseus secondary metabolites by high-performance liquid chromatography. J Chromatogr A. 2002;955:87-93 pubmed
    Two direct HPLC analytical methods for the screening of the major indole alkaloids of Catharanthus roseus hairy roots and their iridoid precursors have been developed. Photodiode array and fluorescence detection were performed...
  9. Su Y, Chen J, Lin C. Phytoplasma-induced floral abnormalities in Catharanthus roseus are associated with phytoplasma accumulation and transcript repression of floral organ identity genes. Mol Plant Microbe Interact. 2011;24:1502-12 pubmed publisher
    ..Many plant pathogens manipulate host plant development to their advantage. It is intriguing to see whether phytoplasmas alter floral development to increase their population...

More Information

Publications62

  1. Runguphan W, O Connor S. Metabolic reprogramming of periwinkle plant culture. Nat Chem Biol. 2009;5:151-3 pubmed publisher
    We transformed an alkaloid biosynthetic gene with reengineered substrate specificity into Catharanthus roseus...
  2. Peebles C, Sander G, Hughes E, Peacock R, Shanks J, San K. The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metab Eng. 2011;13:234-40 pubmed publisher
    The terpenoid indole alkaloid (TIA) pathway in Catharanthus roseus produces two important anticancer drugs, vinblastine and vincristine, in very low yields...
  3. Nayak B, Pinto Pereira L. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats. BMC Complement Altern Med. 2006;6:41 pubmed
    b>Catharanthus roseus L (C. roseus) has been used to treat a wide assortment of diseases including diabetes...
  4. Kumar S, Dutta A, Sinha A, Sen J. Cloning, characterization and localization of a novel basic peroxidase gene from Catharanthus roseus. FEBS J. 2007;274:1290-303 pubmed
    b>Catharanthus roseus (L.) G. Don produces a number of biologically active terpenoid indole alkaloids via a complex terpenoid indole alkaloid biosynthetic pathway...
  5. Courdavault V, Thiersault M, Courtois M, Gantet P, Oudin A, Doireau P, et al. CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. Plant Mol Biol. 2005;57:855-70 pubmed
    ..established RNA interference cell lines targeting the beta subunits of PFT and PGGT-I, respectively, in the Catharanthus roseus C20D cell line, which synthesizes monoterpenoid indole alkaloids in response to auxin depletion from the ..
  6. Ohadoma S, Michael H. Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats. Asian Pac J Trop Med. 2011;4:475-7 pubmed publisher
    To investigate the interacting effects of co-administration of methanol leaf extract of Catharanthus roseus (C. roseus) on the hypoglycemic activity of metformin as well as glibenclamide using experimental rats...
  7. Hughes E, Hong S, Shanks J, San K, Gibson S. Characterization of an inducible promoter system in Catharanthus roseus hairy roots. Biotechnol Prog. 2002;18:1183-6 pubmed
    Transgenic hairy root cultures of Catharanthus roseus were established with a glucocorticoid-inducible promoter controlling the expression of green fluorescent protein (GFP), and GFP expression was characterized...
  8. McCoy E, O Connor S. Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus. J Am Chem Soc. 2006;128:14276-7 pubmed
    ..This work demonstrates that the TIA biosynthetic machinery can be used to produce novel alkaloid structures and also highlights the potential of this pathway for future metabolic engineering efforts. ..
  9. Yu F, De Luca V. ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus. Proc Natl Acad Sci U S A. 2013;110:15830-5 pubmed publisher
    The Madagascar periwinkle (Catharanthus roseus) is highly specialized for the biosynthesis of many different monoterpenoid indole alkaloids (MIAs), many of which have powerful biological activities...
  10. Choi Y, Tapias E, Kim H, Lefeber A, Erkelens C, Verhoeven J, et al. Metabolic discrimination of Catharanthus roseus leaves infected by phytoplasma using 1H-NMR spectroscopy and multivariate data analysis. Plant Physiol. 2004;135:2398-410 pubmed
    A comprehensive metabolomic profiling of Catharanthus roseus L. G...
  11. Hughes E, Hong S, Gibson S, Shanks J, San K. Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels. Biotechnol Bioeng. 2004;86:718-27 pubmed
    ..To test this relationship, transgenic hairy root cultures of Catharanthus roseus were established with a glucocorticoid-inducible promoter controlling the expression of an Arabidopsis ..
  12. Hong S, Hughes E, Shanks J, San K, Gibson S. Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. Biotechnol Prog. 2003;19:1105-8 pubmed
    ..considerably inhibited the accumulation of the alkaloids ajmalicine, tabersonine, and lochnericine by Catharanthus roseus hairy root cultures in the exponential growth phase...
  13. Murata J, De Luca V. Localization of tabersonine 16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus. Plant J. 2005;44:581-94 pubmed
    The Madagascar periwinkle (Catharanthus roseus) produces the well known and remarkably complex anticancer dimeric alkaloids vinblastine and vincristine, which are derived by the coupling of vindoline and catharanthine monomers...
  14. Mahroug S, Courdavault V, Thiersault M, St Pierre B, Burlat V. Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs. Planta. 2006;223:1191-200 pubmed
    b>Catharanthus roseus produces a wide range of secondary metabolites, some of which present high therapeutic values such as antitumoral monoterpenoid indole alkaloids (MIAs), vinblastine and vincristine, and the hypotensive MIA, ajmalicine...
  15. Bernhardt P, McCoy E, O Connor S. Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle. Chem Biol. 2007;14:888-97 pubmed
    Monoterpene indole alkaloids from Catharanthus roseus (Madagascar periwinkle), such as the anticancer agents vinblastine and vincristine, have important pharmacological activities...
  16. Shokeen B, Choudhary S, Sethy N, Bhatia S. Development of SSR and gene-targeted markers for construction of a framework linkage map of Catharanthus roseus. Ann Bot. 2011;108:321-36 pubmed publisher
    b>Catharanthus roseus is a plant of great medicinal importance, yet inadequate knowledge of its genome structure and the unavailability of genomic resources have been major impediments in the development of improved varieties...
  17. Pan Q, Wang Q, Yuan F, Xing S, Zhao J, Choi Y, et al. Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. PLoS ONE. 2012;7:e43038 pubmed publisher
    ..In this study, the ORCA3 (Octadecanoid-derivative Responsive Catharanthus AP2-domain) gene alone or integrated with the G10H (geraniol 10-hydroxylase) gene were first introduced into C...
  18. Burlat V, Oudin A, Courtois M, Rideau M, St Pierre B. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-d. Plant J. 2004;38:131-41 pubmed
    ..Many secondary metabolites, such as monoterpene indole alkaloids (MIAs) in Catharanthus roseus, are also synthesised from this source of IPP...
  19. Wang Q, Yuan F, Pan Q, Li M, Wang G, Zhao J, et al. Isolation and functional analysis of the Catharanthus roseus deacetylvindoline-4-O-acetyltransferase gene promoter. Plant Cell Rep. 2010;29:185-92 pubmed publisher
    Madagascar periwinkle (Catharanthus roseus) produces many therapeutically valuable terpenoid indole alkaloids (TIAs), such as vinblastine and vincristine derived from the monomers vindoline and catharanthine...
  20. Lacava P, Araujo W, Azevedo J. Evaluation of endophytic colonization of Citrus sinensis and Catharanthus roseus seedlings by endophytic bacteria. J Microbiol. 2007;45:11-4 pubmed
    ..This bacterium may also colonize some model plants, such as Catharanthus roseus and Nicotiana clevelandii...
  21. Verma P, Mathur A. Agrobacterium tumefaciens-mediated transgenic plant production via direct shoot bud organogenesis from pre-plasmolyzed leaf explants of Catharanthus roseus. Biotechnol Lett. 2011;33:1053-60 pubmed publisher
    ..of Agrobacterium tumefaciens-mediated transgenic plants, via direct shoot bud organogenesis from leaves of Catharanthus roseus, is reported. A...
  22. Wang C, Liu H, Gao X, Zhang H. Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production. Plant Cell Rep. 2010;29:887-94 pubmed publisher
    ..of genes that function in the terpenoid indole alkaloids (TIAs) biosynthesis pathway have been identified in Catharanthus roseus...
  23. Laffer S, Hamdi S, Lupinek C, Sperr W, Valent P, Verdino P, et al. Molecular characterization of recombinant T1, a non-allergenic periwinkle (Catharanthus roseus) protein, with sequence similarity to the Bet v 1 plant allergen family. Biochem J. 2003;373:261-9 pubmed
    ..T1, a cytokinin-inducible cytoplasmic periwinkle ( Catharanthus roseus ) protein, with significant sequence similarity to members of the Bet v 1 plant allergen family, was ..
  24. Pauw B, van Duijn B, Kijne J, Memelink J. Activation of the oxidative burst by yeast elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis. Plant Mol Biol. 2004;55:797-805 pubmed
    In Catharanthus roseus cell suspensions, expression of several terpenoid indole alkaloid (TIA) biosynthetic genes, including those encoding strictosidine synthase and tryptophan decarboxylase, is coordinately induced by fungal elicitors ..
  25. Shimano F, Ashihara H. Effect of long-term phosphate starvation on the levels and metabolism of purine nucleotides in suspension-cultured Catharanthus roseus cells. Phytochemistry. 2006;67:132-41 pubmed
    ..up to 3 weeks on the levels of purine nucleotides and related compounds was examined using suspension-cultured Catharanthus roseus cells...
  26. Lee Parsons C, Ertürk S, Tengtrakool J. Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation. Biotechnol Lett. 2004;26:1595-9 pubmed
    The optimum growth stage for enhancing ajmalicine production in Catharanthus roseus cultures with methyl jasmonate (MJ) was after 6 d growth. MJ added at 10 or 100 microm on day 6 gave a maximum ajmalicine production of 10...
  27. Pauw B, Hilliou F, Martin V, Chatel G, de Wolf C, Champion A, et al. Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus. J Biol Chem. 2004;279:52940-8 pubmed
    In Catharanthus roseus cell suspensions, the expression of several terpenoid indole alkaloid biosynthetic genes, including two genes encoding strictosidine synthase (STR) and tryptophan decarboxylase (TDC), is coordinately induced by ..
  28. De Pinho P, Gonçalves R, Valentão P, Pereira D, Seabra R, Andrade P, et al. Volatile composition of Catharanthus roseus (L.) G. Don using solid-phase microextraction and gas chromatography/mass spectrometry. J Pharm Biomed Anal. 2009;49:674-85 pubmed publisher
    ..volatile and semi-volatile components were formally or tentatively identified in flowers, leaves and stems of Catharanthus roseus (L.) G. Don (cv...
  29. Raina S, Wankhede D, Jaggi M, Singh P, Jalmi S, Raghuram B, et al. CrMPK3, a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids. BMC Plant Biol. 2012;12:134 pubmed publisher
    ..The biologically active monoterpenoid indole alkaloids (MIA) produced in Catharanthus roseus are known to be induced under several abiotic stress conditions such as wounding, UV-B etc...
  30. Guirimand G, Guihur A, Poutrain P, Héricourt F, Mahroug S, St Pierre B, et al. Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus. J Plant Physiol. 2011;168:549-57 pubmed publisher
    Vindoline constitutes the main terpenoid indole alkaloid accumulated in leaves of Catharanthus roseus, and four genes involved in its biosynthesis have been identified...
  31. Pomahacová B, Dusek J, Dusková J, Yazaki K, Roytrakul S, Verpoorte R. Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter. J Plant Physiol. 2009;166:1405-12 pubmed publisher
    The biosynthetic pathway of monoterpenoid indole alkaloids in Catharanthus roseus is located throughout various membranes at both the cellular and intercellular levels...
  32. van der Heijden R, Jacobs D, Snoeijer W, Hallard D, Verpoorte R. The Catharanthus alkaloids: pharmacognosy and biotechnology. Curr Med Chem. 2004;11:607-28 pubmed
    The Catharanthus (or Vinca) alkaloids comprise a group of about 130 terpenoid indole alkaloids. Vinblastine is now marketed for more than 40 years as an anticancer drug and became a true lead compound for drug development...
  33. Vázquez Flota F, Carrillo Pech M, Minero García Y, de Lourdes Miranda Ham M. Alkaloid metabolism in wounded Catharanthus roseus seedlings. Plant Physiol Biochem. 2004;42:623-8 pubmed
    The effect of mechanical wounding on alkaloid metabolism was analyzed in Catharanthus roseus seedlings. Wounding induced an increase in ajmalicine accumulation, whereas catharanthine remained unaffected...
  34. Giddings L, Liscombe D, Hamilton J, Childs K, DellaPenna D, Buell C, et al. A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus. J Biol Chem. 2011;286:16751-7 pubmed publisher
    ..Co-expression analysis of putative cytochrome P450 genes in the Catharanthus roseus transcriptome identified candidate genes with expression profiles similar to known terpene indole ..
  35. Ruiz May E, De la Peña C, Galaz Avalos R, Lei Z, Watson B, Sumner L, et al. Methyl jasmonate induces ATP biosynthesis deficiency and accumulation of proteins related to secondary metabolism in Catharanthus roseus (L.) G. hairy roots. Plant Cell Physiol. 2011;52:1401-21 pubmed publisher
    ..Using Catharanthus roseus hairy roots, we were able to observe the effect of MeJA on growth inhibition, cell disorganization and ..
  36. Yokoshima S, Ueda T, Kobayashi S, Sato A, Kuboyama T, Tokuyama H, et al. Stereocontrolled total synthesis of (+)-vinblastine. J Am Chem Soc. 2002;124:2137-9 pubmed
  37. Suttipanta N, Pattanaik S, Gunjan S, Xie C, Littleton J, Yuan L. Promoter analysis of the Catharanthus roseus geraniol 10-hydroxylase gene involved in terpenoid indole alkaloid biosynthesis. Biochim Biophys Acta. 2007;1769:139-48 pubmed
    ..The Catharanthus roseus G10H controls the first committed step in biosynthesis of terpenoid indole alkaloids (TIA). The C...
  38. Montiel G, Breton C, Thiersault M, Burlat V, Jay Allemand C, Gantet P. Transcription factor Agamous-like 12 from Arabidopsis promotes tissue-like organization and alkaloid biosynthesis in Catharanthus roseus suspension cells. Metab Eng. 2007;9:125-32 pubmed
    In Catharanthus roseus, monomeric terpenoid indole alkaloids (TIAs) are biosynthesized in specific tissues, particularly in roots, but failed to be produced by in vitro undifferentiated suspension cells...
  39. Leménager D, Ouelhazi L, Mahroug S, Veau B, St Pierre B, Rideau M, et al. Purification, molecular cloning, and cell-specific gene expression of the alkaloid-accumulation associated protein CrPS in Catharanthus roseus. J Exp Bot. 2005;56:1221-8 pubmed
    ..of monoterpenoid indole alkaloid (MIA) accumulation in cell-suspension cultures of Madagascar periwinkle (Catharanthus roseus (L.) G. Don) was performed by two-dimensional polyacrylamide gel electrophoresis...
  40. Musetti R, Grisan S, Polizzotto R, Martini M, Paduano C, Osler R. Interactions between 'Candidatus Phytoplasma mali' and the apple endophyte Epicoccum nigrum in Catharanthus roseus plants. J Appl Microbiol. 2011;110:746-56 pubmed publisher
    ..molecular interactions between 'Candidatus Phytoplasma mali' and the apple endophyte Epicoccum nigrum in the experimental host Catharanthus roseus to determine whether inoculation of endophyte could trigger defence reactions in the host.
  41. Taneja J, Jaggi M, Wankhede D, Sinha A. Effect of loss of T-DNA genes on MIA biosynthetic pathway gene regulation and alkaloid accumulation in Catharanthus roseus hairy roots. Plant Cell Rep. 2010;29:1119-29 pubmed publisher
    ..In Catharanthus roseus, hairy roots are known to show different morphologies, growth patterns, and alkaloid contents...
  42. Peebles C, Hughes E, Shanks J, San K. Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time. Metab Eng. 2009;11:76-86 pubmed publisher
    ..regulator ORCA3, which has a role in regulating the terpenoid indole alkaloid (TIA) pathway within Catharanthus roseus. The TIA pathway leads to the production of the anticancer drugs vinblastine and vincristine...
  43. Jacobs D, van Rijssen M, van der Heijden R, Verpoorte R. Sequential solubilization of proteins precipitated with trichloroacetic acid in acetone from cultured Catharanthus roseus cells yields 52% more spots after two-dimensional electrophoresis. Proteomics. 2001;1:1345-50 pubmed
    ..To analyze the proteome of the medicinal plant Catharanthus roseus, we developed and evaluated a sequential solubilization procedure for the solubilization of proteins ..
  44. Zhang H, Hedhili S, Montiel G, Zhang Y, Chatel G, Pré M, et al. The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. Plant J. 2011;67:61-71 pubmed publisher
    ..In Catharanthus roseus, the AP2/ERF-domain transcription factor ORCA3 controls the jasmonate-responsive expression of several ..
  45. Jaleel C, Manivannan P, Sankar B, Kishorekumar A, Panneerselvam R. Calcium chloride effects on salinity-induced oxidative stress, proline metabolism and indole alkaloid accumulation in Catharanthus roseus. C R Biol. 2007;330:674-83 pubmed
    b>Catharanthus roseus (L.) G. Don...
  46. Singh S, Vats P, Suri S, Shyam R, Kumria M, Ranganathan S, et al. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J Ethnopharmacol. 2001;76:269-77 pubmed
    Hypoglycemic activity was detected in dichloromethane:methanol extract (1:1) of leaves and twigs of Catharanthus roseus (family Apocynaceae), a traditionally used medicinal plant, using streptozotocin (STZ) induced diabetic rat model...
  47. Zhou H, Tai Y, Sun C, Pan Y. Rapid identification of vinca alkaloids by direct-injection electrospray ionisation tandem mass spectrometry and confirmation by high-performance liquid chromatography-mass spectrometry. Phytochem Anal. 2005;16:328-33 pubmed
    A simple and rapid method for the identification of Vinca alkaloids from a crude extract of Catharanthus roseus G. Don (Apocynaceae) by direct-injection electrospray ionisation (ESI) and tandem mass spectrometry (MS/MS) has been developed...
  48. Rischer H, Oresic M, Seppanen Laakso T, Katajamaa M, Lammertyn F, Ardiles Diaz W, et al. Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc Natl Acad Sci U S A. 2006;103:5614-9 pubmed
    ..We report here a comprehensive profiling analysis of the Madagascar periwinkle (Catharanthus roseus), a source of the anticancer drugs vinblastine and vincristine...
  49. Tikhomiroff C, Allais S, Klvana M, Hisiger S, Jolicoeur M. Continuous selective extraction of secondary metabolites from Catharanthus roseus hairy roots with silicon oil in a two-liquid-phase bioreactor. Biotechnol Prog. 2002;18:1003-9 pubmed
    A two-liquid-phase bioreactor was designed to extract indole alkaloids from Catharanthus roseus hairy roots with silicon oil...
  50. Dutta A, Singh D, Kumar S, Sen J. Transcript profiling of terpenoid indole alkaloid pathway genes and regulators reveals strong expression of repressors in Catharanthus roseus cell cultures. Plant Cell Rep. 2007;26:907-15 pubmed
    ..alkaloid (TIA) metabolism is known to a certain extent in cell cultures of an important TIA yielding plant, Catharanthus roseus, though it is not yet complete...
  51. Jaggi M, Kumar S, Sinha A. Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus. Appl Microbiol Biotechnol. 2011;90:1005-16 pubmed publisher
    ..However, very little information is available concerning their role in Catharanthus roseus...
  52. Costa M, Hilliou F, Duarte P, Pereira L, Almeida I, Leech M, et al. Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus. Plant Physiol. 2008;146:403-17 pubmed
    b>Catharanthus roseus produces low levels of two dimeric terpenoid indole alkaloids, vinblastine and vincristine, which are widely used in cancer chemotherapy...
  53. Ara N, Rashid M, Amran M. Comparison of hypotensive and hypolipidemic effects of Catharanthus roseus leaves extract with atenolol on adrenaline induced hypertensive rats. Pak J Pharm Sci. 2009;22:267-71 pubmed
    The leaves extract of Catharanthus roseus was investigated for hypotensive and hypolipidemic effects in adrenaline-induced hypertensive rats (AIHR) and compared with those of Atenolol in a crossover design...