Summary: A plant genus of the family PYROLACEAE. The common name of wintergreen is more often used for GAULTHERIA.

Top Publications

  1. Lee M, Lee J, Jun S, Lee S, Kim N, Lee J, et al. The anti-inflammatory effects of Pyrolae herba extract through the inhibition of the expression of inducible nitric oxide synthase (iNOS) and NO production. J Ethnopharmacol. 2007;112:49-54 pubmed
    ..PH also inhibited the activating phosphorylation of p38 MAP kinase and NF-kappaB in these cells. These results provide a scientific basis to explain the effects of PH as an anti-inflammatory folk remedy in Asian countries...
  2. Ding C, Liu J, Wang J, Wang C, Ji Y, Li X, et al. [Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury in rats]. Zhong Yao Cai. 2007;30:1105-9 pubmed
    ..To investigate the protective effect of Total Flavonoid of Herba Pyrolae(TFHP) on acute myocardial ischemic injury in rats...
  3. Ptitsyn L, Nomura K, Sklyar I, Ravcheeva A. The 1,4-naphthoquinone derivative from Pyrola rotundifolia activates AMPK phosphorylation in C2C12 myotubes. Fitoterapia. 2011;82:1285-9 pubmed publisher
    An aqueous ethanol extract of Pyrola rotundifolia L. induced AMP-activated protein kinase (AMPK) phosphorylation in C2C12 myotubes...
  4. Liu M, Xiao G, Rong P, Zhang Z, Dong J, Zhao H, et al. Therapeutic effects of radix dipsaci, pyrola herb, and Cynomorium songaricum on bone metabolism of ovariectomized rats. BMC Complement Altern Med. 2012;12:67 pubmed publisher
    The objective of this study was to evaluate the effects of herbal medicines, such as Radix Dipsaci (RDD), Pyrola Herb (PHD), and Cynomorium songaricum decoction (CSD), on osteoporotic rats induced by ovariectomy (OVX).
  5. Lallemand F, Puttsepp Ü, Lang M, Luud A, Courty P, Palancade C, et al. Mixotrophy in Pyroleae (Ericaceae) from Estonian boreal forests does not vary with light or tissue age. Ann Bot. 2017;120:361-371 pubmed publisher
    ..Mixotrophic 13C enrichment was detected at studied sites for Pyrola chlorantha and Orthilia secunda (except at one site for the latter), but not for Chimaphila umbellata, Pyrola ..
  6. Uesugi T, Nakano M, Selosse M, Obase K, Matsuda Y. Pyrola japonica, a partially mycoheterotrophic Ericaceae, has mycorrhizal preference for russulacean fungi in central Japan. Mycorrhiza. 2016;26:819-829 pubmed
    ..g., in the genus Pyrola (Monotropoideae, Ericaceae)...
  7. Kirillov V, Stikhareva T, Atazhanova G, Serafimovich M, Mukanov B, Adekenov S, et al. Chemical Composition of the Essential Oil of the Boreal Relict of Pyrola rotundifolia L. from Northern Kazakhstan. J Oleo Sci. 2015;64:1065-73 pubmed publisher
    In Kazakhstan Pyrola rotundifolia L. is the plant-relict in the flora of insular pine forests of the region of low hillocks and declivities in Kazakhstan - a group of insular pine forests of Kokshetau, Bayanaul and Karkaralinsk...
  8. Zhang D, Yao X, Duan M, Luo M, Zhao C, Zu Y, et al. An effective homogenate-assisted negative pressure cavitation extraction for the determination of phenolic compounds in pyrola by LC-MS/MS and the evaluation of its antioxidant activity. Food Funct. 2015;6:3323-33 pubmed publisher
    ..cavitation extraction (HNPCE), was designed for the extraction and determination of the main phenolic compounds of Pyrola incarnata Fisch. by LC-MS/MS...
  9. Yang X, Liu A, Liu S, Xu X, Huang L. Screening for Neuraminidase Inhibitory Activity in Traditional Chinese Medicines Used to Treat Influenza. Molecules. 2016;21: pubmed publisher
    ..It was found that Chinese medicine extracts from Pyrola calliantha, Cynanchum wilfordii, Balanophora involucrata and Paeonia delavayi significantly inhibited ..

More Information


  1. Shutoh K, Izuno A, Isagi Y, Kurosawa T, Kaneko S. Development of microsatellite markers for partially and putative fully mycoheterotrophic varieties of Pyrola japonica sensu lato (Ericaceae). Genes Genet Syst. 2017;92:99-103 pubmed publisher
    ..markers to compare the genetic variation and reproductive biology between the partially mycoheterotrophic Pyrola japonica var. japonica and the putative fully mycoheterotrophic P. japonica var. subaphylla...
  2. Shutoh K, Kaneko S, Suetsugu K, Naito Y, Kurosawa T. Variation in vegetative morphology tracks the complex genetic diversification of the mycoheterotrophic species Pyrola japonica sensu lato. Am J Bot. 2016;103:1618-29 pubmed publisher
    ..b>Pyrola japonica sensu lato is an ideal model for examining the evolution of mycoheterotrophy, owing to its variable leaf ..
  3. Zhang D, Zhang N, Song P, Hao J, Wan Y, Yao X, et al. Functionalized cellulose beads with three dimensional porous structure for rapid adsorption of active constituents from Pyrola incarnata. Carbohydr Polym. 2018;181:560-569 pubmed publisher
    ..32% and 3.92%, which were 4.08 and 4.23 times higher than those in the Pyrola extracts...
  4. Wang P, Gao Y, Sun X, Guo N, Li J, Wang W, et al. Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway. Food Chem Toxicol. 2017;102:129-142 pubmed publisher
    2'-O-galloylhyperin (2'-O-GH), an active compound isolated from Pyrola calliantha, possesses remarkable antioxidant activity...
  5. Jia S, Nakano T, Hattori M, Nara K. Root-associated fungal communities in three Pyroleae species and their mycobiont sharing with surrounding trees in subalpine coniferous forests on Mount Fuji, Japan. Mycorrhiza. 2017;27:733-745 pubmed publisher
    ..Here, we examined root-associated fungal communities in three co-existing Pyroleae species, including Pyrola alpina, Pyrola incarnata, and Orthilia secunda, with reference to co-existing ECM fungi on the surrounding trees ..
  6. Liu L, Li A, Zhao M, Tu P. Tetralones and flavonoids from Pyrola calliantha. Chem Biodivers. 2007;4:2932-7 pubmed
    ..pyrolones A (1) and B (2), and a new flavonol glycoside, 2''-O-(4-hydroxybenzoyl)hyperin (3), were isolated from Pyrola calliantha (whole plant), together with six structurally related compounds, including 2''-O-galloylhyperin (4), ..
  7. Hashimoto Y, Fukukawa S, Kunishi A, Suga H, Richard F, Sauve M, et al. Mycoheterotrophic germination of Pyrola asarifolia dust seeds reveals convergences with germination in orchids. New Phytol. 2012;195:620-30 pubmed publisher
    ..We observed experimental Pyrola asarifolia germination at four Japanese sites and investigated the germination pattern and symbiotic fungi, which ..
  8. Hynson N, Weis M, Preiss K, Gebauer G, Treseder K. Fungal host specificity is not a bottleneck for the germination of Pyroleae species (Ericaceae) in a Bavarian forest. Mol Ecol. 2013;22:1473-81 pubmed publisher
    ..techniques and phylogenetic tests to identify the fungi associated with seedlings of two Pyroleae species, Pyrola chlorantha and Orthilia secunda...
  9. Chen Y, Tan C, Tan J, Qu S, Jiang S, Zhu D. Two new isomeric alpha-tetralones from Pyrola calliantha. Planta Med. 2008;74:1826-8 pubmed publisher
    ..with a known alpha-tetralone ( 3) and four known flavonoids ( 4 - 7) were isolated from the 50 % EtOH extract of Pyrola calliantha...
  10. Ren F, Yang Y, Zhang A, Zhang Y, Zhao Y. [A new naphthaquinone derivative from Pyrola calliantha H. Andres]. Yao Xue Xue Bao. 2010;45:1025-7 pubmed
    To investigate the chemical constituents of hemostatic extract of Pyrola calliantha H. Andres, the extract was subjected to chromatographic separation and purification...
  11. Zhang D, Yao X, Duan M, Luo M, Wang W, Fu Y, et al. An effective negative pressure cavitation-microwave assisted extraction for determination of phenolic compounds in P. calliantha H. Andr. Analyst. 2013;138:4631-41 pubmed publisher
    ..assisted extraction technique (NMAE) was first proposed and applied for extraction of phenolic compounds from pyrola. [C?MIM]BF? aqueous solution was selected as extraction solvent...
  12. Nelson C, Halpern C, Antos J. Variation in responses of late-seral herbs to disturbance and environmental stress. Ecology. 2007;88:2880-90 pubmed
    ..demographic changes, and physiological acclimation of three clonal herbs (Asarum caudatum, Clintonia uniflora, and Pyrola picta) that differ in belowground morphology and leaf longevity...
  13. Lu P, Liu J, Liu N, Xu L. [Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury induced by isoproterenol in rats]. Zhong Yao Cai. 2010;33:73-6 pubmed
    ..To investigate the protective effect of total flavonoid of Herba Pyrolae (TFHP) on acute myocardial ischemic injury induced by isoproterenol in rats and the primary mechanisms...
  14. Isogai N, Yamamura Y, Mariko S, Nakano T. Seasonal pattern of photosynthetic production in a subalpine evergreen herb, Pyrola incarnata. J Plant Res. 2003;116:199-206 pubmed
    The seasonal pattern of growth and matter production of Pyrola incarnata, an evergreen herb on the forest floor in subalpine deciduous forests, was analyzed to understand the ecological significance of evergreenness in a subalpine climate ..
  15. Kim J, Shim S, Xu Y, Kang S, Son K, Chang H, et al. Phenolic glycosides from Pyrola japonica. Chem Pharm Bull (Tokyo). 2004;52:714-7 pubmed
    ..5-O-beta-D-xylopyranosyl(1-->6)-beta-D-glucopyranoside (10), were isolated from the whole plants of Pyrola japonica (Pyrolaceae), together with androsin, (-)-syringaresinol glucoside, homoarbutin, pirolatin, hyperin, ..
  16. Chang J, Inui T. Novel phenolic glycoside dimer and trimer from the whole herb of Pyrola rotundifolia. Chem Pharm Bull (Tokyo). 2005;53:1051-3 pubmed
    From the water-soluble constituents of the whole herb of Pyrola rotundifolia (Pyrolaceae), one novel phenolic glycoside dimer, pyrolaside A (1), and one novel phenolic glycoside trimer, pyrolaside B (2), together with two known phenolic ..
  17. Cai L, Ye H, Li X, Lin Y, Yu F, Chen J, et al. Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells. Int J Oncol. 2013;42:1452-8 pubmed publisher
    ..PHVO demonstrated potent antitumor activity against SW1353 cells, suggesting its potential use as a therapeutic agent in the treatment of chondrosarcoma...
  18. Liu L, Chen Y, Wan Z, Li A, Li R, Tu P. [Studies on chemical constituents of in herb Pyrola calliatha]. Zhongguo Zhong Yao Za Zhi. 2007;32:1762-5 pubmed
    To investigate the chemical constituents of Pyrola calliatha.
  19. Odontuya G, Hoult J, Houghton P. Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides. Phytother Res. 2005;19:782-6 pubmed
    ..The presence of ortho-dihydroxy groups at the B ring and OH substitution pattern at C-5 position of the A ring could significantly contribute to the antiinflammatory and antioxidant activities of flavonoids...
  20. Meng L, Geng Z, Yin J, Wang H, Ji P. [Chemical properties and enzyme activities of rhizosphere and non-rhizosphere soils under six Chinese herbal medicines on Mt. Taibai of Qinling Mountains, Northwest China]. Ying Yong Sheng Tai Xue Bao. 2012;23:2685-92 pubmed
    ..of rhizosphere and non-rhizosphere soils in different habitats of six Chinese herbal medicines, including Pyrola decorata, Cephalotaxus fortunei, Polygonatum odoratum, Potentilla glabra, Polygonum viviparum, and Potentilla ..
  21. Mo Z, Wu L, Yang J, Wang D. [Studies on separation, purification and structure characteristics of a polysaccharide LTC-II from Pyrola corbieri]. Zhongguo Zhong Yao Za Zhi. 2011;36:1633-6 pubmed
    To characterize the structure of polysaccharide LTC-II obtained from Pyrola corbieri.
  22. Zhang Y, Chen X, Sun Y, Bi K. [Determination of flavonoid glycosides in Pyrola decorate by reversed-phase high performance liquid chromatography]. Se Pu. 2007;25:367-70 pubmed
    ..namely hyperin, isoquercitrin, 2"-O-galloylhyperin, quercetin 3-O-alpha-L-arabinofuranoside and quercitrin in Pyrola decorate...
  23. Zhang Y, Zhang C, Ren R, Liu R. Simultaneous determination of seven major triterpenoids in Pyrola decorata H. Andres by LC-MS method. Pharmazie. 2012;67:822-6 pubmed
    ..ester, ziyuglycoside I, pomolic acid, maslinic acid, colosic acid, oleanolic acid and ursolic acid in Pyrola decorata H. Andres...
  24. Li X, Zhou Y, Huang X, He G, Zhou S, Huang H. [Pharmacological actions of different species form genus Pyrola]. Zhong Yao Cai. 1997;20:402-6 pubmed
    This paper reporst the pharmacological actions and toxicities of the water extracts from Pyrola calliantha, Pyrola decorta and P. forrestiana. The results show that the actions of P...