tribulus

Summary

Summary: A plant genus of the family ZYGOPHYLLACEAE. Members contain steroidal saponins. Ingestion by grazing animals causes PHOTOSENSITIVITY DISORDERS called geeldikkop (yellow thick head) in South Africa.

Top Publications

  1. De Combarieu E, Fuzzati N, Lovati M, Mercalli E. Furostanol saponins from Tribulus terrestris. Fitoterapia. 2003;74:583-91 pubmed
    An HPLC-ELSD-ESI-MS method has been developed for the analysis of the steroidal saponins in the aerial parts of Tribulus terrestris...
  2. Al Ali M, Wahbi S, Twaij H, Al Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol. 2003;85:257-60 pubmed
    b>Tribulus terrestris L. (Zygophyllaceae) which is called Al-Gutub (in Iraqi dialect) or Quti;ba (in classical Arabic medicine), and Zea mays were both used alone or in combination by Iraqi herbalists to propel urinary stones...
  3. Gauthaman K, Ganesan A. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat. Phytomedicine. 2008;15:44-54 pubmed
    Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the management of erectile dysfunction (ED). TT extract was administered intravenously, as a bolus dose of 7...
  4. Berkman Z, Tanriover G, Acar G, Sati L, Altug T, Demir R. Changes in the brain cortex of rabbits on a cholesterol-rich diet following supplementation with a herbal extract of Tribulus terrestris. Histol Histopathol. 2009;24:683-92 pubmed publisher
    Extracts of the medicinal herb Tribulus terrestris (TT) are used for treating various diseases. The saponins, a component of TT, play a role in regulating blood pressure and in treatment of hyperlipidemia...
  5. Li M, Qu W, Wang Y, Wan H, Tian C. [Hypoglycemic effect of saponin from Tribulus terrestris]. Zhong Yao Cai. 2002;25:420-2 pubmed
    To study the hypoglycemic effect of saponin from Tribulus terrestris L.
  6. El Tantawy W, Hassanin L. Hypoglycemic and hypolipidemic effects of alcoholic extract of Tribulus alatus in streptozotocin-induced diabetic rats: a comparative study with T. terrestris (Caltrop). Indian J Exp Biol. 2007;45:785-90 pubmed
    ..alatus extract was significantly higher than that of the rats treated with T. terrestris. The results indicate that alcoholic extract of T. alatus possesses hypoglycemic activity in type-1 model of diabetes...
  7. El Tantawy W, Temraz A, El Gindi O. Free serum testosterone level in male rats treated with Tribulus alatus extracts. Int Braz J Urol. 2007;33:554-8; discussion 558-9 pubmed
    The present study was undertaken to investigate the effect of Tribulus alatus extracts on free serum testosterone in male rats.
  8. Amin A, Lotfy M, Shafiullah M, Adeghate E. The protective effect of Tribulus terrestris in diabetes. Ann N Y Acad Sci. 2006;1084:391-401 pubmed
    b>Tribulus terrestris L (TT) is used in the Arabic folk medicine to treat various diseases. The aim of this article was to investigate the protective effects of TT in diabetes mellitus (DM)...
  9. Zhang J, Xu Z, Cao Y, Chen H, Yan L, An M, et al. Antifungal activities and action mechanisms of compounds from Tribulus terrestris L. J Ethnopharmacol. 2006;103:76-84 pubmed
    ..We used bioassay-guided fractionation to have isolated eight steroid saponins from Tribulus terrestris L...

More Information

Publications88

  1. Neychev V, Mitev V. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. J Ethnopharmacol. 2005;101:319-23 pubmed
    The aim of the current study is to investigate the influence of Tribulus terrestris extract on androgen metabolism in young males.
  2. Martino Andrade A, Morais R, Spercoski K, Rossi S, Vechi M, Golin M, et al. Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats. J Ethnopharmacol. 2010;127:165-70 pubmed publisher
    Investigate the possible effects of Tribulus terrestris (TT) on endocrine sensitive organs in intact and castrated male rats as well as in a post-menopausal rat model using ovariectomized females.
  3. Sharifi A, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci. 2003;73:2963-71 pubmed
    b>Tribulus terrestris is a natural herb used for treating many diseases including hypertension. According to previous reports, aqueous extract of tribulus fruits may have some antihypertensive effect with an unknown mechanism...
  4. Wang S, Ji Y, Li H, Yang S. [Mechanisms of gross saponins of Tribulus terrestris via activating PKCepsilon against myocardial apoptosis induced by oxidative stress]. Yao Xue Xue Bao. 2009;44:134-9 pubmed
    This study is to observe the effect of gross saponins of Tribulus terrestris (GSTT) on protein kinase Cepsilon (PKCepsilon) and apoptosis-associated protein in the apoptosis of cultured cardiocyte apoptosis induced by hydrogen peroxide (..
  5. Al Bayati F, Al Mola H. Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq. J Zhejiang Univ Sci B. 2008;9:154-9 pubmed publisher
    Antimicrobial activity of organic and aqueous extracts from fruits, leaves and roots of Tribulus terrestris L...
  6. Rogerson S, Riches C, Jennings C, Weatherby R, Meir R, Marshall Gradisnik S. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Strength Cond Res. 2007;21:348-53 pubmed
    b>Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15, 18). Although some manufacturers claim T...
  7. Balasubramani S, Murugan R, Ravikumar K, Venkatasubramanian P. Development of ITS sequence based molecular marker to distinguish, Tribulus terrestris L. (Zygophyllaceae) from its adulterants. Fitoterapia. 2010;81:503-8 pubmed publisher
    b>Tribulus terrestris L. (Zygophyllaceae) is one of the highly traded raw drugs and also used as a stimulative food additive in Europe and USA. While, Ayurvedic Pharmacopoeia of India recognizes T...
  8. Aggarwal A, Tandon S, Singla S, Tandon C. Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris. Int Braz J Urol. 2010;36:480-8; discussion 488, 489 pubmed
    ..The present study attempted to evaluate the antilithiatic properties of Tribulus terrestris commonly called as "gokhru" which is often used in ayurveda to treat various urinary ..
  9. Zhang S, Qu W, Zhong S. [Inhibitory effects of saponins from Tribulus terrestris on alpha-glucosidase in small intestines of rats]. Zhongguo Zhong Yao Za Zhi. 2006;31:910-3 pubmed
    To determine the effects of saponins from Tribulus terrestris (STT) on small intestinal a-glucosidase and postprandial blood glucose levels in rats.
  10. Kam S, Do J, Choi J, Jeon B, Roh G, Hyun J. In vivo and in vitro animal investigation of the effect of a mixture of herbal extracts from Tribulus terrestris and Cornus officinalis on penile erection. J Sex Med. 2012;9:2544-51 pubmed publisher
    ..Herbal preparations have long been used as folk remedies for erectile dysfunction (ED)...
  11. Sun W, Li H, Yang S. A triterpene saponin from Tribulus terrestris attenuates apoptosis in cardiocyte via activating PKC signalling transduction pathway. J Asian Nat Prod Res. 2008;10:39-48 pubmed
    ..of hecogenin-3-O-beta-D-glucopyranosyl(1-->4)-beta-D-galactopyranoside (1), which is a triterpene saponin of Tribulus terrestris in cardiocytes during chemical hypoxia-ischaemia in vitro...
  12. Zhang J, Cao Y, Xu Z, Sun H, An M, Yan L, et al. In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against fluconazole-resistant fungal pathogens. Biol Pharm Bull. 2005;28:2211-5 pubmed
    ..Saponins are known to be antifungal and antibacterial. We have isolated eight steroid saponins from Tribulus terrestris L., namely TTS-8, TTS-9, TTS-10, TTS-11, TTS-12, TTS-13, TTS-14 and TTS-15...
  13. Perrone A, Plaza A, Bloise E, Nigro P, Hamed A, Belisario M, et al. Cytotoxic furostanol saponins and a megastigmane glucoside from tribulus parvispinus. J Nat Prod. 2005;68:1549-53 pubmed
    ..spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis...
  14. Joshi V, Parekh B, Joshi M, Vaidya A. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata. Urol Res. 2005;33:80-6 pubmed
    ..The action of the putatively litholytic medicinal plants Tribulus terrestris and Bergenia ligulata on the growth of CHPD crystals was studied ...
  15. Gauthaman K, Adaikan P. Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J Ethnopharmacol. 2005;96:127-32 pubmed
    b>Tribulus terrestris L. (Zygophyllaceae) have been used as an aphrodisiac both in the Indian and Chinese traditional systems of medicine...
  16. Ivanova A, Serly J, Dinchev D, Ocsovszki I, Kostova I, Molnar J. Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators. In Vivo. 2009;23:545-50 pubmed
    ..Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line...
  17. Mathur M, Sundaramoorthy S. Ethnopharmacological studies of Tribulus terrestris (Linn). in relation to its aphrodisiac properties. Afr J Tradit Complement Altern Med. 2012;10:83-94 pubmed
    Synergism and antagonism impact of different plant metabolites present in crude fruit extract of Tribulus terrestris 'the herbal Viagra' have been studied...
  18. Huang J, Tan C, Jiang S, Zhu D. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res. 2003;5:285-90 pubmed
    ..named terrestrinins A (1) and B (2), along with six known compounds were isolated from the Chinese medicine herb Tribulus terrestris, and their chemical structures were elucidated as 26-O-beta-D-glucopyranosyl-(25S)-furostan-4(5),20(22)..
  19. Wang J, Zu X, Jiang Y. Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities. Nat Prod Res. 2009;23:1436-44 pubmed publisher
    ..chloromaloside E (3), terrestrinin B (4) and terrestroneoside A (5) were isolated from the dry fruits of Tribulus terrestris...
  20. Sarwat M. ISSR: a reliable and cost-effective technique for detection of DNA polymorphism. Methods Mol Biol. 2012;862:103-21 pubmed publisher
    ..We have outlined here the whole methodology of this technique with an example of Tribulus terrestris as case study.
  21. Dell Agli M, Galli G, Dal Cero E, Belluti F, Matera R, Zironi E, et al. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008;71:1513-7 pubmed publisher
    Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, and icariin, were screened against ..
  22. Chen G, Su L, Feng S, Lu X, Wang H, Pei Y. Furostanol saponins from the fruits of Tribulus terrestris. Nat Prod Res. 2013;27:1186-90 pubmed publisher
    Two new steroidal saponins were isolated from the fruits of Tribulus terrestris...
  23. Campanelli M, De Thomasis R, Tenaglia R. Priapism caused by 'Tribulus terrestris'. Int J Impot Res. 2016;28:39-40 pubmed publisher
    ..man was diagnosed with a 72-h-lasting priapism that occurred after the assumption of a Herbal supplement based on Tribulus terrestris, which is becoming increasingly popular for the treatment of sexual dysfunction...
  24. Silambarasan R, Ayyanar M. An ethnobotanical study of medicinal plants in Palamalai region of Eastern Ghats, India. J Ethnopharmacol. 2015;172:162-78 pubmed publisher
    ..Wettst., Canarium strictum Roxb., Centella asiatica (L.) Urban., Senna auriculata (L.) Roxb. and Tribulus terrestris (L...
  25. Liu S, Cui M, Liu Z, Song F, Mo W. Structural analysis of saponins from medicinal herbs using electrospray ionization tandem mass spectrometry. J Am Soc Mass Spectrom. 2004;15:133-41 pubmed
    The underivatized saponins from Tribulus terrestris and Panax ginseng have been investigated by electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n))...
  26. Kamenov Z, Fileva S, Kalinov K, Jannini E. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017;99:20-26 pubmed publisher
    The primary objectives were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with erectile dysfunction (ED) and with or without ..
  27. Gandhi S, Srinivasan B, Akarte A. Potential nephrotoxic effects produced by steroidal saponins from hydro alcoholic extract of Tribulus terrestris in STZ-induced diabetic rats. Toxicol Mech Methods. 2013;23:548-57 pubmed publisher
    ..The present study investigated the potential effects of the hydroalcoholic extract of Tribulus terrestris, a plant of Zygophyllaceae family, on the renal complications in streptozotocin (STZ)-induced diabetic ..
  28. Salgado R, Marques Silva M, Goncalves E, Mathias A, Aguiar J, Wolff P. Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertile men. Andrologia. 2017;49: pubmed publisher
    Male fertility can be evaluated through complete semen analysis. Plants belonging to the Tribulus genus are known for their role in enhancing sex hormone levels and semen quality. The aim of this study was to evaluate the effects of T...
  29. Tütüncü Konyar S, Ozturk N, Dane F. Occurrence, types and distribution of calcium oxalate crystals in leaves and stems of some species of poisonous plants. Bot Stud. 2014;55:32 pubmed publisher
    ..Caryophyllaceae), Chelidonium majus L. (Papaveraceae), Hypericum perforatum L. (Hypericaceae), Tribulus terrestris L. (Zygophyllaceae), Cynanchum acutum L. (Asclepiadaceae), and Nerium oleander L. (Apocynaceae)...
  30. Lakshmi G, Kumar P, Bharavi K, Annapurna P, Rajendar B, Patel P, et al. Protective effect of Tribulus terrestris linn on liver and kidney in cadmium intoxicated rats. Indian J Exp Biol. 2012;50:141-6 pubmed
    ..Coadministration of ethonolic extract of T. terrestris or vitamin E along with Cd significantly reversed the Cd induced changes along with significant reduction in Cd load. ..
  31. Capece M, Romeo G, Ruffo A, Romis L, Mordente S, Di Lauro G. A phytotherapic approach to reduce sperm DNA fragmentation in patients with male infertility. Urologia. 2017;84:79-82 pubmed publisher
    ..We studied the effects on semen analysis and on DNA fragmentation of in vivo admnistration of Myo-Inositol and Tribulus Terrestris plus Alga Ecklonia plus Biovis (Tradafertil; Tradapharma Sagl, Swizerland) in men with previously ..
  32. Wang Z, Wang B, Zhao Y, Wang F, Sun Y, Guo R, et al. Furostanol and Spirostanol Saponins from Tribulus terrestris. Molecules. 2016;21:429 pubmed publisher
    ..terrestris. The structures of the new compounds were established on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS, and comparisons with published data. ..
  33. Sun B, Qu W, Bai Z. [The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro]. Zhong Yao Cai. 2003;26:104-6 pubmed
    The inhibitory effect of saponins from Tribulus terrestris (STT) on Bcap37 breast cancer cell line were determined by cell growth curve, MTT assay, protein content assay and morphological observation...
  34. Zhang S, Li H, Yang S. Tribulosin suppresses apoptosis via PKC epsilon and ERK1/2 signaling pathway during hypoxia/reoxygenation in neonatal rat ventricular cardiac myocytes. J Asian Nat Prod Res. 2011;13:1135-45 pubmed publisher
    ..1-4)-[a-L-rhamnopyranosyl(1-2)]-?-D-galactopyranoside), a component of gross saponins of Tribulus terrestris, has been shown to produce cytoprotective effects in heart...
  35. Jagadeesan G, Kavitha A, Subashini J. FT-IR Study of the influence of Tribulus terrestris on Mercury intoxicated mice, Mus musculus liver. Trop Biomed. 2005;22:15-22 pubmed
    ..Methanol fractions of Tribulus terrestris fruit extract was administrated on mercury intoxicated mice for 15 days...
  36. Phillips O, Mathew K, Oriowo M. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. J Ethnopharmacol. 2006;104:351-5 pubmed
    The effects of methanolic and aqueous extracts of Tribulus terrestris on rat blood pressure (BP) and the perfused mesenteric vascular bed were investigated...
  37. Kovac J, Pan M, Arent S, Lipshultz L. Dietary Adjuncts for Improving Testosterone Levels in Hypogonadal Males. Am J Mens Health. 2016;10:NP109-NP117 pubmed
    ..as well as other "over-the-counter" options like DHEA (dehydroepiandrosterone) and herbal remedies like Tribulus terrestris This review will focus on the use of these adjunct medications in isolation, or in combination with ..
  38. Li M, Guan Y, Liu J, Zhai F, Zhang X, Guan L. Cellular and molecular mechanisms in vascular smooth muscle cells by which total saponin extracted from Tribulus terrestris protects against artherosclerosis. Cell Physiol Biochem. 2013;32:1299-308 pubmed publisher
    Total saponin extracted from Tribulus terrestris (TSETT) has been reported to protect against atherosclerosis. We here investigate the cellular and molecular mechanisms of TSETT underlying protection against atherosclerosis...
  39. Neychev V, Nikolova E, Zhelev N, Mitev V. Saponins from Tribulus terrestris L are less toxic for normal human fibroblasts than for many cancer lines: influence on apoptosis and proliferation. Exp Biol Med (Maywood). 2007;232:126-33 pubmed
    The objective of the study was to explore the influence of saponins derived from Tribulus terrestris L. (TT) on normal human skin fibroblasts and to compare it with their anticancer properties...
  40. Siddiqui M, Rasheed S, Saquib Q, Al Khedhairy A, al Said M, Musarrat J, et al. In-Vitro dual inhibition of protein glycation, and oxidation by some Arabian plants. BMC Complement Altern Med. 2016;16:276 pubmed publisher
    ..The data revealed that out of 26 medicinal plants, five plants viz. Sida cordifolia, Plumbago zeylanica, Tribulus terrestris, Glycyrrhiza glabra, and Rosa indica were active against the in-vitro protein glycation with IC50 ..
  41. Han M, Yang L, Han D, Yang L. [Study on fitting growth density and best harvest time of Tribulus terrestris]. Zhongguo Zhong Yao Za Zhi. 2008;33:750-3 pubmed
    To study the suitable growth density and the optimal harvest time of Tribulus terrestris. Four growth densities were set with 60 cm breadth ridge and individual distance of 10, 20, 30 and 50 cm...
  42. Kaur K, Sharma V, Singh V, Wani M, Gupta R. Development of novel SSR markers for evaluation of genetic diversity and population structure in Tribulus terrestris L. (Zygophyllaceae). 3 Biotech. 2016;6:156 pubmed publisher
    b>Tribulus terrestris L., commonly called puncture vine and gokhru, is an important member of Zygophyllaceae...
  43. Cao M, Hu S, Zhang C, Wang Y. [The effects of Baisong tablet on the behaviors and CRHmRNA expression in the brain of rats following chronic stress]. Zhongguo Zhong Yao Za Zhi. 2005;30:219-22 pubmed
    ..To investigate the effects of Baisong tablet on the behaviors and CRHmRNA expression in the chronic stress rats...
  44. Tomczynska M, Malinowska J, Morel A, Hamed A, Oleszek W, Stochmal A, et al. Comparative antiadhesive properties of crude extract and phenolic fraction isolated from aerial parts of Tribulus pterocarpus during severe hyperhomocysteinemia. Food Chem Toxicol. 2013;56:266-71 pubmed publisher
    The phenolic fraction and the crude extract from Tribulus pterocarpus have different biological activity, including antiplatelet-antiadhesive properties...
  45. Xu T, Xu Y, Xie S, Zhao H, Han D, Li Y, et al. Two new furostanol saponins from Tribulus terrestris L. J Asian Nat Prod Res. 2008;10:419-23 pubmed publisher
    Two new furostanol saponins, tribufurosides B (1) and C (2), were isolated from the fruits of Tribulus terrestris L...
  46. Yan L, Lu Y, Zheng S, Wang A, Li M, Ruan J, et al. Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in rat brain. Am J Chin Med. 2011;39:325-33 pubmed
  47. Kim H, Kim J, Min J, Kim M, Kim J, Kor M, et al. Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-?B signaling in liver cancer cells. J Ethnopharmacol. 2011;136:197-203 pubmed publisher
    A medicinal herb Tribulus terrestris Linn has been used to treat various diseases including hepatocellular carcinoma...
  48. Dehghan A, Esfandiari A, Bigdeli S. Alternative treatment of ovarian cysts with Tribulus terrestris extract: a rat model. Reprod Domest Anim. 2012;47:e12-5 pubmed publisher
    b>Tribulus terrestris has long been used in traditional medicine to treat impotency and improve sexual functions in man. The aim of this study was to evaluate the efficiency of T...
  49. Gopinath V, Mubarakali D, Priyadarshini S, Priyadharsshini N, Thajuddin N, Velusamy P. Biosynthesis of silver nanoparticles from Tribulus terrestris and its antimicrobial activity: a novel biological approach. Colloids Surf B Biointerfaces. 2012;96:69-74 pubmed publisher
    ..The plant, Tribulus terrestris L...
  50. Bourke C. Motor neurone disease in molybdenum-deficient sheep fed the endogenous purine xanthosine: possible mechanism for Tribulus staggers. Aust Vet J. 2012;90:272-4 pubmed publisher
    The occurrence of Tribulus terrestris motor neurone disease (MND) in sheep is linked with grazing Tribulus growing on cultivation paddocks...
  51. Hamed A, Janda B, Mahalel U, Stochmal A, Oleszek W. Profiles of steroidal saponins from the aerial parts of Tribulus pentandrus, T. megistopterus subsp. pterocarpus and T. parvispinus by LC-ESI-MS/MS. Phytochem Anal. 2012;23:613-21 pubmed publisher
    b>Tribulus is a well-known pharmaceutical herb that has been used for a long time in the traditional Chinese and Indian systems of medicine for the treatment of various diseases...
  52. Tuncer M, Yaymaci B, Sati L, Cayli S, Acar G, Altug T, et al. Influence of Tribulus terrestris extract on lipid profile and endothelial structure in developing atherosclerotic lesions in the aorta of rabbits on a high-cholesterol diet. Acta Histochem. 2009;111:488-500 pubmed publisher
    The aim of this study was to investigate the pleotropic effects of an extract of a traditional herb, Tribulus terrestris (TT), on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed a cholesterol-..
  53. Ercan P, El S. Inhibitory effects of chickpea and Tribulus terrestris on lipase, α-amylase and α-glucosidase. Food Chem. 2016;205:163-9 pubmed publisher
    The total saponin content and its in vitro bioaccessibilities in Tribulus terrestris and chickpea were determined by a static in vitro digestion method (COST FA1005 Action INFOGEST)...
  54. Kavitha P, Ramesh R, Bupesh G, Stalin A, Subramanian P. Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus). In Vitro Cell Dev Biol Anim. 2011;47:698-706 pubmed publisher
    The potential protective role of Tribulus terrestris in acetaminophen-induced hepatotoxicity in Oreochromis mossambicus was investigated. The effect of oral exposure of acetaminophen (500 mg/kg) in O...
  55. Sarwat M, Das S, Srivastava P. Analysis of genetic diversity through AFLP, SAMPL, ISSR and RAPD markers in Tribulus terrestris, a medicinal herb. Plant Cell Rep. 2008;27:519-28 pubmed
    b>Tribulus terrestris is well known for its medicinal importance in curing urino-genital disorders...
  56. Milasius K, Dadeliene R, Skernevicius J. The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes' organism homeostasis. Fiziol Zh. 2009;55:89-96 pubmed
    The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes' organism homeostase was investigated...
  57. Singh S, Raghavendra K, Singh R, Mohanty S, Dash A. Evaluation of Tribulus terrestris Linn (Zygophyllaceae) acetone extract for larvicidal and repellence activity against mosquito vectors. J Commun Dis. 2008;40:255-61 pubmed
    Acetone extracts of leaves and seeds from the Tribulus terrestris (Zygophyllaceae) were tested against mature and immature different mosquito vectors under laboratory condition...
  58. Saudan C, Baume N, Emery C, Strahm E, Saugy M. Short term impact of Tribulus terrestris intake on doping control analysis of endogenous steroids. Forensic Sci Int. 2008;178:e7-10 pubmed publisher
    b>Tribulus terrestris is a nutritional supplement highly debated regarding its physiological and actual effects on the organism...
  59. Hammoda H, Ghazy N, Harraz F, Radwan M, ElSohly M, Abdallah I. Chemical constituents from Tribulus terrestris and screening of their antioxidant activity. Phytochemistry. 2013;92:153-9 pubmed publisher
    ..oligosaccharides (1,2) and a stereoisomer of di-p-coumaroylquinic acid (3) were isolated from the aerial parts of Tribulus terrestris along with five known compounds (4-8)...
  60. Conrad J, Dinchev D, Klaiber I, Mika S, Kostova I, Kraus W. A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. Fitoterapia. 2004;75:117-22 pubmed
    The phytochemical investigation of the aerial parts of Tribulus terrestris of Bulgarian origin has resulted in the isolation of the novel furostanol saponin 1, named tribol, together with the known spirostanol saponins 2 and 3 and ..
  61. Yang H, Qu W, Sun B. [Experimental study of saponins from Tribulus terrestris on renal carcinoma cell line]. Zhongguo Zhong Yao Za Zhi. 2005;30:1271-4 pubmed
    To investigate the effect of saponins from Tribulus terrestris (STT) on the renal carcinoma cell (786-0) in vitro, and inhibitory mechanisms.
  62. Wang Z, Zhang D, Hui S, Zhang Y, Hu S. Effect of tribulus terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats. J Tradit Chin Med. 2013;33:228-32 pubmed
    To observe the effect of tribulus terrestris saponins (TTS) on behavior and neuroendocrine of chronic mild stress (CMS) depression rats.
  63. Cek S, Turan F, Atik E. The effects of Gokshura, Tribulus terrestris on sex reversal of guppy, Poecilia reticulata. Pak J Biol Sci. 2007;10:718-25 pubmed
    This study examined the effects of Tribulus terrestris (TT) on sex reversal in guppy, Poecilia reticulata. The objective of this study was to introduce a new environmentally friendly method for masculinization in P. reticulata...
  64. Heidari M, Mehrabani M, Pardakhty A, Khazaeli P, Zahedi M, Yakhchali M, et al. The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. Ann N Y Acad Sci. 2007;1095:418-27 pubmed
    b>Tribulus terrestris has been used in traditional medicine for relieving rheumatic pain and as an analgesic plant for a long time...
  65. Mahmood A, Athar M. Scanning electron microscopic observations on micro-organisms in the root nodules of Tribulus terrestris L. (Zygophyllaceae). Scanning. 2006;28:233-5 pubmed
    Scanning electron microscopic observations were made on the micro-organisms of root nodules of Tribulus terrestris L. The results showed that nodules of T. terrestris contained dual infection consisting of Rhizobium sp...
  66. Turfan M, Tasal A, Ergun F, Ergelen M. [A sudden rise in INR due to combination of Tribulus terrestris, Avena sativa, and Panax ginseng (Clavis Panax)]. Turk Kardiyol Dern Ars. 2012;40:259-61 pubmed publisher
    ..In this case report we will present two cases with a sudden rise in INR due to using combination of Tribulus terrestris, Avena sativa and Panax ginseng (Panax Clavis)...
  67. Shirfule A, Sangamwar A, Khobragade C. Exploring glycolate oxidase (GOX) as an antiurolithic drug target: molecular modeling and in vitro inhibitor study. Int J Biol Macromol. 2011;49:62-70 pubmed publisher
    ..We aimed to identify a possible mechanism of action for the anti-GOX leads from Tribuls terrestris, which can be attributed to anti-urolithic drug development. This study found promising in development of future GOX inhibitory leads...
  68. Chen G, Liu T, Lu X, Wang H, Hua H, Pei Y. New steroidal glycosides from Tribulus terrestris L. J Asian Nat Prod Res. 2012;14:780-4 pubmed publisher
    Two new steroidal glycosides were isolated from Tribulus terrestris L...
  69. Gacche R, Dhole N. Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications. Food Chem Toxicol. 2011;49:1806-13 pubmed publisher
    ..Rutaceae), Ficus golmerata L. (Moraceae), Psoralea corlifolia L. (Fabaceae), Tribulus terrestris L. (Zygophyllaceae), and Morinda cetrifolia L...
  70. Aslani M, Movassaghi A, Mohri M, Pedram M, Abavisani A. Experimental Tribulus terrestris poisoning in sheep: clinical, laboratory and pathological findings. Vet Res Commun. 2003;27:53-62 pubmed
    ..The sheep in the experimental group were fed 80% Tribulus terrestris and 20% alfalfa hay and wheat straw, while the control sheep were given a mixture of 40% alfalfa hay ..
  71. Olas B, Morel A, Hamed A, Oleszek W, Stochmal A. Evaluation of polyphenolic fraction isolated from aerial parts of Tribulus pterocarpus on biological properties of blood platelets in vitro. Platelets. 2013;24:156-61 pubmed publisher
    The antiplatelet and antioxidative activity of polyphenolic fraction isolated from aerial parts of Tribulus pterocarpus in blood platelets stimulated by thrombin was studied...
  72. Sansalone S, Russo G, Mondaini N, Cantiello F, Antonini G, Cai T. A combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts is able to improve sexual quality of life in patient with premature ejaculation. Arch Ital Urol Androl. 2016;88:171-176 pubmed publisher
    ..Here, we aimed to evaluate the tolerability and efficacy of a combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts in order to improve sexual quality of life in patients with premature ..
  73. Dinchev D, Janda B, Evstatieva L, Oleszek W, Aslani M, Kostova I. Distribution of steroidal saponins in Tribulus terrestris from different geographical regions. Phytochemistry. 2008;69:176-86 pubmed
    The steroidal saponins of Tribulus terrestris L. (Zygophyllaceae) are considered to be the factor responsible for biological activity of products derived from this plant...
  74. Guo Y, Shi D, Yin H, Chen K. Effects of Tribuli saponins on ventricular remodeling after myocardial infarction in hyperlipidemic rats. Am J Chin Med. 2007;35:309-16 pubmed
    ..05). In conclusion, TS not only lowered serum lipidemia, but also relieved left ventricular remodeling, and improved cardiac function in the early stage after MI...
  75. Song Y, Kim D, Curtis Long M, Park C, Son M, Kim J, et al. Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition. Eur J Med Chem. 2016;114:201-8 pubmed publisher
    The α-glucosidase inhibitory potential of Tribulus terrestris extracts has been reported but as yet the active ingredients are unknown...
  76. Xu Y, Xu T, Liu Y, Xie S, Si Y, Xu D. Two new steroidal glucosides from Tribulus terrestris L. J Asian Nat Prod Res. 2009;11:548-53 pubmed publisher
    Two new furostanol saponins, tribufurosides D (1) and E (2), were isolated from the fruits of Tribulus terrestris L...
  77. Liu T, Chen G, Yi G, Xu J, Zhang T, Hua H, et al. New pregnane and steroidal glycosides from Tribulus terrestris L. J Asian Nat Prod Res. 2010;12:209-14 pubmed publisher
    Three new steroidal saponins were isolated from the fruits of Tribulus terrestris L...
  78. Zhang S, Li H, Yang S. Tribulosin protects rat hearts from ischemia/reperfusion injury. Acta Pharmacol Sin. 2010;31:671-8 pubmed publisher
    To investigate the protective effect of tribulosin, a monomer of the gross saponins from Tribulus terrestris, against cardiac ischemia/reperfusion injury and the underlying mechanism in rats.
  79. Talasaz A, Abbasi M, Abkhiz S, Dashti Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Transplant. 2010;25:3792-3 pubmed publisher
    ..b>Tribulus terrestris is traditionally used because of its aphrodisiac and antiurolithiatic activities with almost complete ..