peganum

Summary

Summary: A plant genus of the family ZYGOPHYLLACEAE. HARMALINE and other ALKALOIDS, phenylpropanoids, and TRITERPENES have been found in plants of this genus.

Top Publications

  1. Monsef H, Ghobadi A, Iranshahi M, Abdollahi M. Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. J Pharm Pharm Sci. 2004;7:65-9 pubmed
    To evaluate the effect of Peganum harmala (Syrian rue) a wild-growing flowering plant belonging to the family Zygophylaceae and found abundantly in Iran on formalin-induced pain response in mice.
  2. Zayed R, Wink M. Beta-carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala. Z Naturforsch C. 2005;60:451-8 pubmed
    ..In root cultures, the formation of beta-carboline alkaloids can be induced by methyljasmonate and several other elicitors indicating that these alkaloids are part of the reactive chemical defence system of Peganum harmala.
  3. Farouk L, Laroubi A, Aboufatima R, Benharref A, Chait A. Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. J Ethnopharmacol. 2008;115:449-54 pubmed
    The seeds of Peganum harmala L. (Pgh) (Zygophyllaceae) have been used in Moroccan traditional medicine for treatment of a various diseases and to relieve dolorous process...
  4. Arshad N, Neubauer C, Hasnain S, Hess M. Peganum harmala can minimize Escherichia coli infection in poultry, but long-term feeding may induce side effects. Poult Sci. 2008;87:240-9 pubmed publisher
    b>Peganum harmala seed extracts have been frequently reported to possess antibacterial potential through in vitro studies, but in vivo studies have acquired less attention...
  5. Frison G, Favretto D, Zancanaro F, Fazzin G, Ferrara S. A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract. Forensic Sci Int. 2008;179:e37-43 pubmed publisher
    ..neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is ..
  6. El Gendy M, El Kadi A. Peganum harmala L. differentially modulates cytochrome P450 gene expression in human hepatoma HepG2 cells. Drug Metab Lett. 2009;3:212-6 pubmed
    b>Peganum harmala L. (Zygophyllaceae) is a common plant in Middle East and it is still used traditionally to treat several diseases. The effect of P...
  7. Ivanova A, Serly J, Christov V, Stamboliyska B, Molnar J. Alkaloids derived from genus Veratrum and Peganum of Mongolian origin as multidrug resistance inhibitors of cancer cells. Fitoterapia. 2011;82:570-5 pubmed publisher
    ..The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was studied...
  8. Astulla A, Zaima K, Matsuno Y, Hirasawa Y, Ekasari W, Widyawaruyanti A, et al. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. J Nat Med. 2008;62:470-2 pubmed publisher
    Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4)...
  9. Khlifi D, Sghaier R, Amouri S, Laouini D, Hamdi M, Bouajila J. Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. Food Chem Toxicol. 2013;55:202-8 pubmed publisher
    In this study, biological activities of methanolic extracts from Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. plants, collected in Centre of Tunisia, were investigated...

More Information

Publications84

  1. Zheng X, Zhang Z, Chou G, Wu T, Cheng X, Wang C, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009;32:1245-51 pubmed publisher
    ..For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to show significant inhibitory activity of acetylcholinesterase enzyme (AChE) using an in vitro TLC-..
  2. Kartal M, Altun M, Kurucu S. HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L. J Pharm Biomed Anal. 2003;31:263-9 pubmed
    ..375-250, 30.750-246, 31.250-500 and 31.000-248 microg/ml, respectively. The method described was suitable for the determination of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.
  3. Nenaah G. Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia. 2010;81:779-82 pubmed publisher
    The ?-carboline alkaloids of Peganum harmala L were extracted through a bioassay-guided fractionation and their antimicrobial activities were investigated. Results revealed significant differences (P>0...
  4. Berrougui H, Martín Cordero C, Khalil A, Hmamouchi M, Ettaib A, Marhuenda E, et al. Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta. Pharmacol Res. 2006;54:150-7 pubmed
    ..However, both alkaloids can act as blockers VOCs, as inhibitors of phosphodiesterase resulting in an increase of the second messenger (cAMP and cGMP) levels and finally reduce the levels of free radicals in tissues...
  5. Shi Z, Wang Z, Xu H, Tian Y, Li X, Bao J, et al. Modeling, docking and dynamics simulations of a non-specific lipid transfer protein from Peganum harmala L. Comput Biol Chem. 2013;47:56-65 pubmed publisher
    ..In this study, an in silico analysis was proposed to study ns-LTP in Peganum harmala L., which may belong to ns-LTP1 family, aiming at constructing its three-dimensional structure...
  6. Xie J, Zhu L, Xu X. Affinitive separation and on-line identification of antitumor components from Peganum nigellastrum by coupling a chromatographic column of target analogue imprinted polymer with mass spectrometry. Anal Chem. 2002;74:2352-60 pubmed
    ..and on-line identification of the antitumor components, harmine and harmaline, from the methanol extract of Peganum nigellastrum seeds...
  7. Wang X, Geng Y, Wang D, Shi X, Liu J. Separation and purification of harmine and harmaline from Peganum harmala using pH-zone-refining counter-current chromatography. J Sep Sci. 2008;31:3543-7 pubmed publisher
    ..counter-current chromatography was successfully applied to the separation of alkaloids from a crude extract of Peganum harmala L. using a multilayer coil planet centrifuge...
  8. Arshad N, Zitterl Eglseer K, Hasnain S, Hess M. Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. Phytother Res. 2008;22:1533-8 pubmed publisher
    ..coli (n = 10) using disc and agar well diffusion assays. Only two plants, Peganum harmala (seeds) and Eucalyptus globulus (leaves) showed positive responses...
  9. Lamchouri F, Zemzami M, Jossang A, Abdellatif A, Israili Z, Lyoussi B. Cytotoxicity of alkaloids isolated from Peganum harmala seeds. Pak J Pharm Sci. 2013;26:699-706 pubmed
    b>Peganum harmala is used in traditional medicine to treat a number of diseases including cancer...
  10. El Gendy M, Somayaji V, El Kadi A. Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects. Planta Med. 2010;76:671-7 pubmed publisher
    ..In the present study, we examined the ability of the methanolic extract of Peganum harmala L...
  11. Herraiz T, Gonzalez D, Ancín Azpilicueta C, Arán V, Guillen H. beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food Chem Toxicol. 2010;48:839-45 pubmed publisher
    b>Peganum harmala L. is a multipurpose medicinal plant increasingly used for psychoactive recreational purposes (Ayahuasca analog)...
  12. Berrougui H, Isabelle M, Cloutier M, Hmamouchi M, Khalil A. Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation. J Pharm Pharmacol. 2006;58:967-74 pubmed
    ..We have investigated the protective effect of Peganum harmala-extract (P-extract) and the two major alkaloids (harmine and harmaline) from the seeds of P...
  13. Derakhshanfar A, Mirzaei M. Effect of Peganum harmala (wild rue) extract on experimental ovine malignant theileriosis: pathological and parasitological findings. Onderstepoort J Vet Res. 2008;75:67-72 pubmed
    ..schizonts in the lymph node smears, treatment of the lambs in Group A with an extract containing the alkaloids of Peganum harmala (wild rue) was commenced. Group B lambs were kept untreated controls...
  14. Li C, Wang Y, Wang C, Yi X, Li M, He X. Anticancer activities of harmine by inducing a pro-death autophagy and apoptosis in human gastric cancer cells. Phytomedicine. 2017;28:10-18 pubmed publisher
    Harmine, a ?-carboline alkaloid from Peganum harmala, has multiple anti-tumor activities, especially for its folk therapy for digestive system neoplasm. However, the underlying mechanism of harmine on gastric cancer remains unclear...
  15. El Dwairi Q, Banihani S. Histo-functional effects of Peganum harmala on male rat's spermatogenesis and fertility. Neuro Endocrinol Lett. 2007;28:305-10 pubmed
    The Peganum harmala is currently used by the Jordanian populations systemically for its antispasmodic, diuretic, sedative and analgesic effects and externally for its antirheumatic effect...
  16. Wang C, Zhang Z, Wang Y, He X. Cytotoxic Constituents and Mechanism from Peganum harmala. Chem Biodivers. 2016;13:961-8 pubmed publisher
    b>Peganum harmala L. is a traditional Chinese and Uygur medicine used to treat cancer. Bioactivity-guided fractionation was applied to determine the cytotoxic constituents from P. harmala...
  17. Shoaib M, Shah S, Ali N, Shah I, Ullah S, Ghias M, et al. Scientific investigation of crude alkaloids from medicinal plants for the management of pain. BMC Complement Altern Med. 2016;16:178 pubmed publisher
    ..from selected medicinal plants (Woodfordia fruticosa, Adhatoda vasica, Chenopodium ambrosioides, Vitex negundo, Peganum harmala and Broussonetia papyrifera) were extracted as per reported literature...
  18. Zhang X, Liu J, Tang P, Liu Z, Guo G, Sun Q, et al. Identification of a New Uncompetitive Inhibitor of Adenosine Deaminase from Endophyte Aspergillus niger sp. Curr Microbiol. 2018;75:565-573 pubmed publisher
    ..Here, 54 morphologically distinct endophyte strains were isolated from six plants such as Peganum harmala Linn., Rheum officinale Baill., Gentiana macrophylla Pall...
  19. Soliman A, Fahmy S. Protective and curative effects of the 15 KD isolated protein from the Peganum harmala L. seeds against carbon tetrachloride induced oxidative stress in brain, tests and erythrocytes of rats. Eur Rev Med Pharmacol Sci. 2011;15:888-99 pubmed
    ..study aimed to evaluate the protective and curative effects of the 15 KD protein isolated from the seeds of Peganum harmala L. against carbon tetrachloride (CCl4) induced oxidative stress in rats...
  20. Filali I, Romdhane A, Znati M, Jannet H, Bouajila J. Synthesis of New Harmine Isoxazoles and Evaluation of their Potential Anti-Alzheimer, Anti-inflammatory, and Anticancer Activities. Med Chem. 2016;12:184-90 pubmed
    Harmine 1 was extracted from the seeds of Peganum harmala...
  21. Aziz M, Adnan M, Khan A, Rehman A, Jan R, Khan J. Ethno-medicinal survey of important plants practiced by indigenous community at Ladha subdivision, South Waziristan agency, Pakistan. J Ethnobiol Ethnomed. 2016;12:53 pubmed
    ..Leaves were the most frequently used plant parts. Highest use values were recorded for Peganum harmala (0.93), Punica granatum (0.91), Thymus mongolicus (0.90), Chenopodium album (0.89), Coriandrum sativum (0...
  22. Liu W, Zhu Y, Wang Y, Qi S, Wang Y, Ma C, et al. Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice. J Ethnopharmacol. 2017;204:95-106 pubmed publisher
    Aerial parts of Peganum harmala Linn (APP) is used as traditional medical herb for treatment of forgetfulness in Uighur medicine in China. But, the active ingredients and underlying mechanisms are unclear...
  23. Apostolico I, Aliberti L, Caputo L, De Feo V, Fratianni F, Nazzaro F, et al. Chemical Composition, Antibacterial and Phytotoxic Activities of Peganum harmala Seed Essential Oils from Five Different Localities in Northern Africa. Molecules. 2016;21: pubmed publisher
    b>Peganum harmala L., also known as Syrian rue or Pègano, is a herbaceous plant belonging to the Zygohpyllaceae family, and is widely used in traditional medicine. The chemical composition of essential oils of P...
  24. Liu X, Li M, Tan S, Wang C, Fan S, Huang C. Harmine is an inflammatory inhibitor through the suppression of NF-?B signaling. Biochem Biophys Res Commun. 2017;489:332-338 pubmed publisher
    Harmine is a major constituent in a hallucinogenic botanical mixture ayahuasca and medical plant Peganum harmala L. The plant is used for various illnesses and exhibits anti-inflammatory activity...
  25. Li S, Cheng X, Wang C. A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum. J Ethnopharmacol. 2017;203:127-162 pubmed publisher
    The plants of the genus Peganum have a long history as a Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma, jaundice, colic, lumbago, and many other human ailments...
  26. Aziz M, Khan A, Adnan M, Izatullah I. Traditional uses of medicinal plants reported by the indigenous communities and local herbal practitioners of Bajaur Agency, Federally Administrated Tribal Areas, Pakistan. J Ethnopharmacol. 2017;198:268-281 pubmed publisher
    ..94), V. indica (0.90), Isodon rugosus (Wall. ex Benth.) Codd (0.88), Foeniculum vulgare Mill. (0.87), Peganum harmala L (0.86), Solanum virginianum L. (0.85), and Cassia fistula L. (0.79)...
  27. Shang X, Guo X, Li B, Pan H, Zhang J, Zhang Y, et al. Microwave-assisted extraction of three bioactive alkaloids from Peganum harmala L. and their acaricidal activity against Psoroptes cuniculi in vitro. J Ethnopharmacol. 2016;192:350-361 pubmed publisher
    b>Peganum harmala L. is a perennial herbaceous, glabrous plant that grows in semi-arid conditions, steppe areas and sandy soils...
  28. Jeppesen A, Soelberg J, Jäger A. Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan. Plants (Basel). 2012;1:74-81 pubmed publisher
    ..Water and ethanol extracts of Ephedra intermedia and the ethanol extracts of Lagochilus cabulicus and Peganum harmala inhibited Staphylococcus aureus at 0.5 mg/mL, and the P...
  29. Shahverdi A, Monsef Esfahani H, Nickavar B, Bitarafan L, Khodaee S, Khoshakhlagh N. Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds. Z Naturforsch C. 2005;60:707-10 pubmed
    The smoke of Peganum harmala seeds is traditionally used in Iran as a disinfectant agent. The aim of this study was to determine the antimicrobial activity of two smoke condensates from Peganum harmala seeds...
  30. Wen F, Zheng L, Li X, Li Y, Zhang L, Cheng X, et al. [Research on quality standards of herbs of Peganum harmala]. Zhongguo Zhong Yao Za Zhi. 2012;37:2971-6 pubmed
    To establish the quality standards of the herbs of Peganum harmala...
  31. Mirzaiedehaghi M. Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala. Onderstepoort J Vet Res. 2006;73:153-5 pubmed
    ..One hundred sheep naturally infected with Theileria lestoquardi were treated with a chloroform extract of the plant Peganum harmala. The treatment was continued for 5 days, the dose of extract being 5 mg/kg per day...
  32. Khaliq T, Misra P, Gupta S, Reddy K, Kant R, Maulik P, et al. Peganine hydrochloride dihydrate an orally active antileishmanial agent. Bioorg Med Chem Lett. 2009;19:2585-6 pubmed publisher
    ..discovery and development on antileishmanial agents from plants, we carried out bioassay guided fractionation on Peganum harmala seeds which resulted in the isolation of 1 as an antileishmanial agent...
  33. Yuruktumen A, Karaduman S, Bengi F, Fowler J. Syrian rue tea: a recipe for disaster. Clin Toxicol (Phila). 2008;46:749-52 pubmed publisher
    b>Peganum harmala, commonly called "Syrian rue," is native to countries around the Mediterranean sea and western United States...
  34. Mirzaei M. Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala. Korean J Parasitol. 2007;45:267-71 pubmed
    ..In this research 50 cattle naturally infected with Theileria annulata were treated with the extract of the plant Peganum harmala. The treatment was continued for 5 days, the dose of the extract being 5 mg/kg per day...
  35. Ma Z, Hano Y, Qiu F, Shao G, Chen Y, Nomura T. Triterpenoids from Peganum nigellastrum. J Asian Nat Prod Res. 2007;9:575-8 pubmed
    Two triterpenoids were isolated from the roots of Peganum nigellastrum Bunge...
  36. Chabir N, Ibrahim H, Romdhane H, Valentin A, Moukarzel B, Mars M, et al. Seeds of Peganum Harmala L. chemical analysis, antimalarial and antioxidant activities, and cytotoxicity against human breast cancer cells. Med Chem. 2014;11:94-101 pubmed
    The present study evaluated the levels of total phenolics, flavonoids, tannins and anthocyanins from Peganum harmala L. seeds and determined their antioxidant, antiplasmodial and anticancer potentials...
  37. Piacentini M, Piatti E, Fraternale D, Ricci D, Albertini M, Accorsi A. Phospholipase C-dependent phosphoinositide breakdown induced by ELF-EMF in Peganum harmala calli. Biochimie. 2004;86:343-9 pubmed
    ..molecule (the precursor of the phosphoinositide signal transduction cascade) by exposing callus cells from Peganum harmala to 50 Hz, 1 gauss EMF for 10 min and by examining the level and the fatty acid composition of PtdIns 4,5-..
  38. Zhao T, Zheng S, Zhang B, Li Y, Bligh S, Wang C, et al. Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy. Food Chem. 2012;134:1096-105 pubmed publisher
    The ?-carboline alkaloids, harmaline and harmine, are present in hallucinogenic plants Ayahuasca and Peganum harmala, and in a variety of foods...
  39. Grabher P, Durieu E, Kouloura E, Halabalaki M, Skaltsounis L, Meijer L, et al. Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts. Planta Med. 2012;78:951-6 pubmed publisher
    ..Follow-up investigation of four extracts led to the targeted isolation of harmine (1, IC?? 0.022 µM) from Peganum harmala, emodin (3, IC?? 4.2 µM) from Cassia nigricans, kaempferol (4, IC?? 0...
  40. Naresh G, Jaiswal N, Sukanya P, Srivastava A, Tamrakar A, Narender T. Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells. Bioorg Med Chem Lett. 2012;22:5648-51 pubmed publisher
    b>Peganum harmala Linn, commonly known as 'harmal' belonging to the family Zygophyllaceae, is one of the most important medicinal plants of India...
  41. Achour S, Saadi H, Turcant A, Banani A, Mokhtari A, Soulaymani A, et al. [Peganum harmala L. poisoning and pregnancy: two cases in Morocco]. Med Sante Trop. 2012;22:84-6 pubmed
    b>Peganum harmala L. (wild or Syrian rue) is commonly used as an emmenagogue and abortifacient in traditional medicine in the Middle East and North Africa including Morocco...
  42. Ma X, Liu D, Tang H, Wang Y, Wu T, Li Y, et al. Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds. Acta Biochim Biophys Sin (Shanghai). 2013;45:87-94 pubmed publisher
    A novel antifungal protein, designated as PHP, was isolated from the seeds of Peganum harmala, by cationic exchange chromatography on Resource S column and gel filtration on Sephadex 75 10/300 GL column...
  43. Zhu Y, Fei Z, Liu M, Jia F, Wu A. Direct one-pot synthesis of luotonin F and analogues via rational logical design. Org Lett. 2013;15:378-81 pubmed publisher
    ..Through a rational logical design, multifundamental reactions (iodination, Kornblum oxidation, and annulation) were assembled in one-pot. The developed approach can efficiently synthesize luntonin F and a diversity of analogues...
  44. Li S, Yang B, Zhang Q, Zhang J, Wang J, Wu W. Synthesis and bioactivity of beta-carboline derivatives. Nat Prod Commun. 2010;5:1591-6 pubmed
    ..79, 5.75, 3.53 and 4.02 microg/mL, respectively. No insecticidal activity against third stage instar larvae of Mythimna separata Walker were observed under the tested concentration...
  45. Biradar S, Joshi H, Tarak K. Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice. Pak J Biol Sci. 2013;16:1687-97 pubmed
    The aim of the study was to isolate the harmine alkaloids from the seeds of Peganum harmala (TAPH) and its cerebroprotective effect on cognitive deficit mice...
  46. Song Z, Liu J, Lu X, Wang L. [Harmine induces apoptosis in human SGC-7901 cells]. Zhong Yao Cai. 2006;29:571-3 pubmed
    ..corrected] To investigate the effect of apoptosis induced in human SGC-7901 cells by Harmine...
  47. Shonouda M, Osman S, Salama O, Ayoub A. Toxical effect of Peganum harmala L. leaves on the cotton leaf worm, Spodoptera littoralis Boisd and its parasitoids Microplitis rufiventris Kok. Pak J Biol Sci. 2008;11:546-52 pubmed
    The leaf extract and its fractions of Peganum harmala L. have shown pronounced mortal effect, decreased percent pupation and adult emergence of the cotton leaf worm, Spodoptera littoralis Boisd...
  48. Lu Y, Li X, He M, Su Y, Zeng F. [Influence of different concentration Ni and Cu on the photosynthesis and chlorophyll fluorescence characteristics of Peganum harmala]. Ying Yong Sheng Tai Xue Bao. 2011;22:936-42 pubmed
    ..200, and 400 mg kg(-1)) Ni and Cu on the growth, photosynthesis, and chlorophyll fluorescence characteristics of Peganum harmala seedlings...
  49. Adhami H, Farsam H, Krenn L. Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition. Phytother Res. 2011;25:1148-52 pubmed publisher
    ..Due to the best activity, the seeds of Peganum harmala L. were investigated in detail...
  50. Ding K, Liu L, Cheng X, Wang C, Wang Z. [Investigation on representation methods of dissolubility property of total alkaloid extract from Peganum harmala]. Zhongguo Zhong Yao Za Zhi. 2010;35:2250-3 pubmed
    To investigate the representation methods of dissolubility property of total alkaloid extract from Peganum hamala in different solvents, and to investigate the evaluation method of the dissolubility property of extracts from traditional ..
  51. Ali S, Hamed A, Soltan M, Hegazy U, Elgorashi E, El Garf I, et al. In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease. BMC Complement Altern Med. 2013;13:121 pubmed publisher
    ..Numerous medicinal plants have been described in old literature of Arabic traditional medicine for treatment of Alzheimer's disease (AD) (or to strengthen memory)...
  52. Illgner S, Matusch R. Biotransformation of desoxypeganine by microsomal enzymes of the rabbit liver. Arch Pharm (Weinheim). 2005;338:49-52 pubmed
    ..This provokes a problem for correct dosage finding in formulations for the treatment of Alzheimer's disease and in the therapy of alcoholism and nicotine dependence...
  53. Im J, Jin Y, Lee J, Yu J, Han X, Im S, et al. Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation. Vascul Pharmacol. 2009;50:147-52 pubmed publisher
  54. Liu B. [Study on chemical constituents of Peganum multisectum]. Zhong Yao Cai. 2011;34:1719-21 pubmed
    To study the chemical consituents of Peganum multisectum.
  55. Nafisi S, Bonsaii M, Maali P, Khalilzadeh M, Manouchehri F. Beta-carboline alkaloids bind DNA. J Photochem Photobiol B. 2010;100:84-91 pubmed publisher
    Beta-carboline alkaloids present in Peganum harmala (harmal) have recently drawn attention due to their antitumor activities...
  56. Nafisi S, Malekabady Z, Khalilzadeh M. Interaction of ?-carboline alkaloids with RNA. DNA Cell Biol. 2010;29:753-61 pubmed publisher
    Carboline alkaloids are present in medicinal plants such as Peganum harmala L., which have been used as folk medicine in anticancer therapy. Recently, they have drawn attention because of their antitumor activities...
  57. Soliman A, Abu El Zahab H, Alswiai G. Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats. Asian Pac J Trop Med. 2013;6:285-95 pubmed publisher
    To evaluate the curative effect of the 132 KD protein isolated from the seeds of Peganum harmala (P. harmala) L. against carbon tetrachloride (CCl(4)) induced oxidative stress in rats...
  58. Ghaffar S, Afridi S, Aftab M, Murtaza M, Syed S, Begum S, et al. Attenuation of palmitate induced insulin resistance in muscle cells by harmala, clove and river red gum. Pak J Pharm Sci. 2016;29:1795-1800 pubmed
    ..Our results showed that extract from Peganum harmala seeds, Eucalyptus camaldulensis and Syzygium aromaticum leaves, showed significant antioxidant activity...
  59. Chen Q, Chao R, Chen H, Hou X, Yan H, Zhou S, et al. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. Int J Cancer. 2005;114:675-82 pubmed
    Beta-carboline alkaloids such as harmine are present in medicinal plants such as Peganum harmala that have been used as folk medicine in anticancer therapy...
  60. Liang J, Cha H, Jahng Y. Recent advances in the studies on luotonins. Molecules. 2011;16:4861-83 pubmed publisher
    Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types...
  61. Li J, Ma J, Wang X, Zhao J. [Micromorphological identification on 3 species of medicinal plants for genus Peganum]. Zhong Yao Cai. 1997;20:14-6 pubmed
    This paper reports the micromorphological features of the leave, pollen grains, petals and seeds of 3 species of medicinal plants of Genus Peganum. The results can supply basis for the identification of the medicinal material.
  62. Li Y, Sattler R, Yang E, Nunes A, Ayukawa Y, Akhtar S, et al. Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology. 2011;60:1168-75 pubmed publisher
    ..Our studies provide potential novel neurotherapeutics by modulating the activity of glutamate transporters via gene activation. This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  63. Zhao T, He Y, Wang J, Ding K, Wang C, Wang Z. Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by ?-carboline alkaloids, harmine derivatives. Phytother Res. 2011;25:1671-7 pubmed publisher
    Carboline alkaloids are the main chemical constituents of the plant Peganum harmala, while they also could be formed endogenously and found in coffee, alcoholic beverages and tobacco...
  64. Movafeghi A, Abedini M, Fathiazad F, Aliasgharpour M, Omidi Y. Floral nectar composition of Peganum harmala L. Nat Prod Res. 2009;23:301-8 pubmed publisher
    Chemical composition of the floral nectar of Peganum harmala, a herbaceous medicinal perennial of the family Zygophyllaceae, was analysed using high-performance liquid chromatography technique...
  65. Pulpati H, Biradar Y, Rajani M. High-performance thin-layer chromatography densitometric method for the quantification of harmine, harmaline, vasicine, and vasicinone in Peganum harmala. J AOAC Int. 2008;91:1179-85 pubmed
    b>Peganum harmala Linn. seed is a reputed drug of the Indian systems of medicine. We report a simple high-performance thin-layer chromatography (HPTLC) densitometric method for the quantification of 4 alkaloids, viz...
  66. Hamden K, Masmoudi H, Ellouz F, ElFeki A, Carreau S. Protective effects of Peganum harmala extracts on thiourea-induced diseases in adult male rat. J Environ Biol. 2008;29:73-7 pubmed
    ..The aim of our study was to characterize the putative protective effects of ethanol and chloroform extracts of Peganum harmala on thiourea-induced diseases in adult male rat...
  67. Zhao T, Wang Z, Branford White C, Xu H, Wang C. Classification and differentiation of the genus Peganum indigenous to China based on chloroplast trnL-F and psbA-trnH sequences and seed coat morphology. Plant Biol (Stuttg). 2011;13:940-7 pubmed publisher
    The genus Peganum (Zygophyllaceae) consists of six species and one subspecies; three of which are distributed in China, P. harmala Linn, P. nigellastrum Bunge and P. multisectum (Maxim.) Bobr...
  68. Oodi A, Norouzi H, Amirizadeh N, Nikougoftar M, Vafaie Z. Harmine, a Novel DNA Methyltransferase 1 Inhibitor in the Leukemia Cell Line. Indian J Hematol Blood Transfus. 2017;33:509-515 pubmed publisher
    ..Harmine, A beta carboline alkaloid derivative of Peganum harmala, had shown anti- proliferative effects on leukemic cell line...
  69. Zaker F, Oody A, Arjmand A. A study on the antitumoral and differentiation effects of peganum harmala derivatives in combination with ATRA on leukaemic cells. Arch Pharm Res. 2007;30:844-9 pubmed
    ..This shows that the direction of differentiation is dominantly determined by ATRA. These preliminary data implies a new approach in treatment of leukemia...
  70. Hamden K, Silandre D, Delalande C, Elfeki A, Carreau S. Protective effects of estrogens and caloric restriction during aging on various rat testis parameters. Asian J Androl. 2008;10:837-45 pubmed publisher
    To investigate the effects of 17beta-estradiol (E2), Peganum harmala extract (PHE) and caloric restriction (CR) on various testis parameters during aging.
  71. Shao H, Huang X, Zhang Y, Zhang C. Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops. Molecules. 2013;18:2623-34 pubmed publisher
    ..Our study revealed that total alkaloids from seeds of the medicinal plant Peganum harmala L...
  72. Singh A, Khaliq T, Chaturvedi J, Narender T, Srivastava A. Anti-diabetic and anti-oxidative effects of 4-hydroxypipecolic acid in C57BL/KsJ-db/db mice. Hum Exp Toxicol. 2012;31:57-65 pubmed publisher
    Hypoglycemic effect of ethanol extracts of Peganum harmala (commonly known as 'Harmal') seeds has been reported on normal and streptozotocin-induced diabetic rats...
  73. Berrougui H, Herrera Gonzalez M, Marhuenda E, Ettaib A, Hmamouchi M. Relaxant activity of methanolic extract from seeds of Peganum harmala on isolated rat aorta. Therapie. 2002;57:236-41 pubmed
    The activity of methanolic extract from the seeds of Peganum harmala L. (MEP) on vascular smooth muscle (rat aorta) was investigated. MEP induced relaxation in aorta precontracted with noradrenaline (10(-6) M) or KCl (80 mM) (IC50 = 14...
  74. Cheng X, Zhao T, Yang T, Wang C, Bligh S, Wang Z. HPLC fingerprints combined with principal component analysis, hierarchical cluster analysis and linear discriminant analysis for the classification and differentiation of Peganum sp. indigenous to China. Phytochem Anal. 2010;21:279-89 pubmed publisher
    Seeds of wild Peganum harmala Linn., P. multisectum (Maxim) Bobr., P. nigellastrum Bunge and a probable indeterminate species, herein referred to as P. variety, are commonly used in Chinese medicine...
  75. Wang J, Luo G, Chen Y, Zheng Y, Zu T. [New record for China of host plant of Cynomorium songaricumpeganum multisectum]. Zhongguo Zhong Yao Za Zhi. 2011;36:3244-6 pubmed
    ..To investigate the distribution and host plants of Cynomorium songaricum, and provide a scientific basis for the artificial cultivation of C. songaricum and protect the ecological environment in the sandy area...