larrea

Summary

Summary: A plant genus of the family ZYGOPHYLLACEAE. It is sometimes called chaparral but that is a generic word which is used with a number of other plants. Members contain NORDIHYDROGUAIARETIC ACID.

Top Publications

  1. Stege P, Davicino R, Vega A, Casali Y, Correa S, Micalizzi B. Antimicrobial activity of aqueous extracts of Larrea divaricata Cav (jarilla) against Helicobacter pylori. Phytomedicine. 2006;13:724-7 pubmed
    We studied here the effect of aqueous extracts of Larrea divaricata Cav on the growth of Helicobacter pylori. Results show that cold extract, infusion, decoction and simulated digestion had inhibitory activity at 0.04-0...
  2. Medeiros J, Pockman W. Drought increases freezing tolerance of both leaves and xylem of Larrea tridentata. Plant Cell Environ. 2011;34:43-51 pubmed publisher
    ..To test this hypothesis, we subjected Larrea tridentata juveniles grown in a greenhouse under well-watered or drought conditions to minimum temperatures ..
  3. Jin V, Evans R. Elevated CO2 increases plant uptake of organic and inorganic N in the desert shrub Larrea tridentata. Oecologia. 2010;163:257-66 pubmed publisher
    ..plant N uptake dynamics, we quantified plant uptake of organic and inorganic N forms in the dominant desert shrub Larrea tridentata under controlled environmental conditions. Seedlings of L...
  4. Konno C, Lu Z, Xue H, Erdelmeier C, Meksuriyen D, Che C, et al. Furanoid lignans from Larrea tridentata. J Nat Prod. 1990;53:396-406 pubmed
    From the leaves and stems of Larrea tridentata six new furanoid lignans, compounds 1-6, have been isolated and their structures determined through interpretation of physical and spectroscopic properties...
  5. Martino R, Davicino R, Mattar M, Casali Y, Correa S, Anesini C, et al. In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (Jarilla) on mouse peritoneal macrophages. Immunopharmacol Immunotoxicol. 2010;32:125-32 pubmed publisher
    b>Larrea divaricata Cav. (Zygophyllaceae) is a plant widely used in Argentina.
  6. Palacio L, Baeza M, Cantero J, Cusidó R, Goleniowski M. In vitro propagation of "jarilla" (Larrea divaricata CAV.) and secondary metabolite production. Biol Pharm Bull. 2008;31:2321-5 pubmed
    An efficient protocol for the in vitro germination and propagation of Larrea divaricata CAV. (Jarilla) was established...
  7. Pedernera A, Guardia T, Calderón C, Rotelli A, de la Rocha N, Genaro S, et al. Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. J Ethnopharmacol. 2006;105:415-20 pubmed
    b>Larrea divaricata Cav. (Zygophyllaceae) is used in popular medicine as anti-inflammatory and anti-rheumatic drug, containing higher amounts of nordihydroguaiaretic acid, a well-known free radical scavenger...
  8. Martins S, Teixeira J, Mussatto S. Solid-state fermentation as a strategy to improve the bioactive compounds recovery from Larrea tridentata leaves. Appl Biochem Biotechnol. 2013;171:1227-39 pubmed publisher
    Chemical composition of Larrea tridentata leaves was determined and elevated content of lignin (35.96 % w/w) was found...
  9. Mangione A, Dearing M, Karasov W. Creosote bush (Larrea tridentata) resin increases water demands and reduces energy availability in desert woodrats (Neotoma lepida). J Chem Ecol. 2004;30:1409-29 pubmed
    ..To address these impacts, we studied the costs of ingestion of resin from creosote bush (Larrea tridentata) on desert woodrats (Neotoma lepida)...

More Information

Publications81

  1. Cho M, Moinuddin S, Helms G, Hishiyama S, Eichinger D, Davin L, et al. (+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush (Larrea tridentata). Proc Natl Acad Sci U S A. 2003;100:10641-6 pubmed
    ..polyphenol oxidase (PPO) was purified approximately 1,700-fold to apparent homogeneity from the creosote bush (Larrea tridentata), and its encoding gene was cloned...
  2. Quiroga E, Sampietro A, Vattuone M. In vitro fungitoxic activity of Larrea divaricata cav. extracts. Lett Appl Microbiol. 2004;39:7-12 pubmed
    To evaluate the fungitoxic activity of Larrea divaricata Cav. extract and one of its components against yeasts and fungi. This activity was compared with the action of ketoconazole, a known synthetic antimycotic.
  3. Haley S, Lamb J, Franklin M, Constance J, Dearing M. "Pharm-ecology" of diet shifting: biotransformation of plant secondary compounds in creosote (Larrea tridentata) by a woodrat herbivore, Neotoma lepida. Physiol Biochem Zool. 2008;81:584-93 pubmed publisher
    ..Populations of N. lepida in the Mojave Desert have evolved over the past 10,000 years to feed on creosote (Larrea tridentata) from an ancestral state of consuming juniper (Juniperus osteosperma)...
  4. Moinuddin S, Hishiyama S, Cho M, Davin L, Lewis N. Synthesis and chiral HPLC analysis of the dibenzyltetrahydrofuran lignans, larreatricins, 8'-epi-larreatricins, 3,3'-didemethoxyverrucosins and meso-3,3'-didemethoxynectandrin B in the creosote bush (Larrea tridentata): evidence for regiospecific con. Org Biomol Chem. 2003;1:2307-13 pubmed
    The creosote bush (Larrea tridentata) lignans are linked via 8-8' bonds, with the simplest apparently being E-p-anol derived...
  5. Hamerlynck E, Huxman T, McAuliffe J, Smith S. Carbon isotope discrimination and foliar nutrient status of Larrea tridentata (creosote bush) in contrasting Mojave Desert soils. Oecologia. 2004;138:210-5 pubmed
    ..Delta), % foliar N, and predawn water potentials (psi(pd)) and midday stomatal conductance ( g(s)) of Larrea tridentata across five Mojave Desert soils with different age-specific surface and sub-surface horizon development ..
  6. Arteaga S, Andrade Cetto A, Cárdenas R. Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. J Ethnopharmacol. 2005;98:231-9 pubmed
    Although controversial, Creosote bush, Larrea tridentata (Sesse and Moc. ex DC) Coville, is used to treat a variety of illnesses including infertility, rheumatism, arthritis, diabetes, gallbladder and kidney stones, pain and inflammation...
  7. Treviño Cueto B, Luis M, Contreras Esquivel J, Rodriguez R, Aguilera A, Aguilar C. Gallic acid and tannase accumulation during fungal solid state culture of a tannin-rich desert plant (Larrea tridentata Cov.). Bioresour Technol. 2007;98:721-4 pubmed
    b>Larrea tridentata (Sesse & Mocino ex DC...
  8. Barker D, Vanier C, Naumburg E, Charlet T, Nielsen K, Newingham B, et al. Enhanced monsoon precipitation and nitrogen deposition affect leaf traits and photosynthesis differently in spring and summer in the desert shrub Larrea tridentata. New Phytol. 2006;169:799-808 pubmed
    ..to affect leaf trait-photosynthesis relationships differently in the short- and long-term for the desert shrub Larrea tridentata...
  9. Cella Pizarro L, Bisigato A. Allocation of biomass and photoassimilates in juvenile plants of six Patagonian species in response to five water supply regimes. Ann Bot. 2010;106:297-307 pubmed publisher
    ..species (Jarava speciosa, Grindelia chiloensis, Prosopis alpataco, Bougainvillea spinosa, Chuquiraga erinacea and Larrea divaricata) were investigated in terms of total biomass and resource allocation patterns in response to a water ..
  10. Torregrossa A, Azzara A, Dearing M. Testing the diet-breadth trade-off hypothesis: differential regulation of novel plant secondary compounds by a specialist and a generalist herbivore. Oecologia. 2012;168:711-8 pubmed publisher
    ..Neotoma albigula, fed diets with increasing concentrations of phenolic resin extracted from the creosote bush (Larrea tridentata), which produces a suite of PSCs novel to both species...
  11. Arteaga S, Carmona A, Luis J, Andrade Cetto A, Cárdenas R. Effect of Larrea tridentata (creosote bush) on cholesterol gallstones and bile secretion in hamsters. J Pharm Pharmacol. 2005;57:1093-9 pubmed
    b>Larrea tridentata (Sesse and Moc. ex DC.) Coville is used for the treatment of gallstones in traditional Mexican medicine. The possible prevention or elimination of gallstones by ethanolic and aqueous extracts of the leaves and twigs of L...
  12. Kauma H, Koskela R, Makisalo H, Autio Harmainen H, Lehtola J, Hockerstedt K. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand J Gastroenterol. 2004;39:1168-71 pubmed
    ..Primary liver biopsy showed severe toxic hepatitis consistent with previous reports of chaparral-induced liver damage. Later, 6 months after the liver function tests had normalized, permanent hepatic fibrosis could still be seen. ..
  13. Mangione A, Dearing D, Karasov W. Detoxification in relation to toxin tolerance in desert woodrats eating creosote bush. J Chem Ecol. 2001;27:2559-78 pubmed
    ..to a mixture of naturally occurring plant secondary metabolites (mostly phenolics) in resin from creosote bush (Larrea tridentata)...
  14. Anesini C, Turner S, Borda E, Ferraro G, Coussio J. Effect of Larrea divaricata Cav. extract and nordihydroguaiaretic acid upon peroxidase secretion in rat submandibulary glands. Pharmacol Res. 2004;49:441-8 pubmed
    ..b>Larrea divaricata Cav. is a plant used in folk Argentine medicine for the treatment of cancer and inflammatory ailments...
  15. Varela M, Arslan I, Reginato M, Cenzano A, Luna M. Phenolic compounds as indicators of drought resistance in shrubs from Patagonian shrublands (Argentina). Plant Physiol Biochem. 2016;104:81-91 pubmed publisher
    ..between phenolic compounds content, water availability and oxidative damage were evaluated in two native shrubs: Larrea divaricata (evergreen) and Lycium chilense (deciduous) of Patagonian shrublands by their means and/or by ..
  16. Canale F, Dávila S, Sasso C, Pellarín N, Mattar Domínguez M. Immunization with Larrea divaricata Cav. proteins elicits opsonic antibodies against Pseudomonas aeruginosa and induces phagocytic activity of murine macrophages. Microb Pathog. 2018;118:257-267 pubmed publisher
    ..b>Larrea divaricata Cav...
  17. Agüero M, Svetaz L, Sánchez M, Luna L, Lima B, López M, et al. Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity. Food Chem Toxicol. 2011;49:1970-8 pubmed publisher
    ..The lignan and volatile organic compounds (VOCs) profiles from propolis matched with those of exudates of Larrea nitida providing strong evidences on its botanical origin...
  18. Kohl K, Dearing M. Experience matters: prior exposure to plant toxins enhances diversity of gut microbes in herbivores. Ecol Lett. 2012;15:1008-15 pubmed publisher
    ..we compared experienced populations that independently converged to feed on the same toxic plant (creosote bush, Larrea tridentata) to naïve populations with no exposure to creosote toxins...
  19. Minckley R, Roulston T, Williams N. Resource assurance predicts specialist and generalist bee activity in drought. Proc Biol Sci. 2013;280:20122703 pubmed publisher
  20. Chan J, Bittner S, Bittner A, Atwal S, Shen W, Inayathullah M, et al. Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice. J Pharmacol Exp Ther. 2018;365:281-290 pubmed publisher
  21. Portilla de Buen E, Ramos L, Aguilar A, Ramos A, Garcia Martinez D, Cárdenas A, et al. [Larrea tridentata. Effect on a non-metabolic model of urolithiasis in rats]. Rev Med Inst Mex Seguro Soc. 2008;46:519-22 pubmed
    ..It produced no alterations in body weight gain, blood counts, or water intake. Future work is needed to completely rule out any effect of the plant on urolith formation. ..
  22. Stege P, Sombra L, Davicino R, Olsina R. Analysis of nordihydroguaiaretic acid in Larrea divaricata Cav. extracts by micellar electrokinetic chromatography. Phytochem Anal. 2011;22:74-9 pubmed publisher
    b>Larrea divaricata Cav. is a common shrub used in folk medicine to treat a variety of diseases. The main product extracted from this bush is nordihydroguaiaretic acid (NDG), which is a potent antioxidant...
  23. Grabher P, Durieu E, Kouloura E, Halabalaki M, Skaltsounis L, Meijer L, et al. Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts. Planta Med. 2012;78:951-6 pubmed publisher
    ..6 µM), 3,3',4'-tri-O-methylmyricetin (12, IC?? 7.1 µM) and ombuin (15, IC?? 1.7 µM) from Larrea tridentata as the active constituents...
  24. Strobel G, Singh S, Riyaz Ul Hassan S, Mitchell A, Geary B, Sears J. An endophytic/pathogenic Phoma sp. from creosote bush producing biologically active volatile compounds having fuel potential. FEMS Microbiol Lett. 2011;320:87-94 pubmed publisher
    A Phoma sp. was isolated and characterized as endophytic and as a pathogen of Larrea tridentata (creosote bush) growing in the desert region of southern Utah, USA...
  25. Ahn J, Pei Y, Chae H, Kim S, Kim Y, Choi Y, et al. Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production. Molecules. 2018;23: pubmed publisher
    Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav...
  26. Jitsuno M, Mimaki Y. Triterpene glycosides from the aerial parts of Larrea tridentata. Phytochemistry. 2010;71:2157-67 pubmed publisher
    Chemical study of the aerial parts of Larrea tridentata (Zygophyllaceae) resulted in the isolation of 25 triterpene glycosides, 13 of which were previously unknown...
  27. Henderson J, Hazra S, Dunkle A, Salvucci M, Wachter R. Biophysical characterization of higher plant Rubisco activase. Biochim Biophys Acta. 2013;1834:87-97 pubmed publisher
    ..No significant changes in aggregation are observed upon replacement of ADP with ATP. However, in the absence of nucleotides, the major protein population appears to consist of a monodisperse oligomer smaller than a hexamer. ..
  28. Davicino R, Mattar A, Casali Y, Porporatto C, Correa S, Micalizzi B. Activation and apoptosis of mouse peritoneal macrophages by extracts of Larrea divaricata Cav. (jarilla). Int Immunopharmacol. 2006;6:2047-56 pubmed
    Two aqueous extracts, decoction and infusion from Larrea divaricata Cav. (Zygophyllaceae) were investigated for immunomodulating activity on peritoneal macrophages (MPhi)...
  29. Van Slambrouck S, Daniels A, Hooten C, Brock S, Jenkins A, Ogasawara M, et al. Effects of crude aqueous medicinal plant extracts on growth and invasion of breast cancer cells. Oncol Rep. 2007;17:1487-92 pubmed
    ..tridentata, J. communis L. and A. californica. This study provides original scientific data on the anticancer activity of selected aqueous medicinal plant extracts used in traditional medicine...
  30. Campanella M, Bertiller M. Leaf growth dynamics in four plant species of the Patagonian Monte, Argentina. J Plant Res. 2013;126:497-503 pubmed publisher
    ..We selected four dominant species of the two main life forms. The species selected were two evergreen shrubs: Larrea divaricata and Chuquiraga avellanedae and two perennial grasses: Nassella tenuis and Pappostipa speciosa...
  31. McCalley C, Sparks J. Controls over nitric oxide and ammonia emissions from Mojave Desert soils. Oecologia. 2008;156:871-81 pubmed publisher
    ..Addition of labile C reduces gaseous N losses, presumably by increasing microbial immobilization, whereas addition of NO(3) (-) stimulates NO and NH(3) efflux...
  32. Kurnath P, Merz N, Dearing M. Ambient temperature influences tolerance to plant secondary compounds in a mammalian herbivore. Proc Biol Sci. 2016;283: pubmed publisher
    ..in the desert woodrat (Neotoma lepida), a herbivorous rodent that naturally encounters PSCs in creosote bush (Larrea tridentata), which is a major component of its diet...
  33. Puttock A, Dungait J, Bol R, Dixon E, Macleod C, Brazier R. Stable carbon isotope analysis of fluvial sediment fluxes over two contrasting C(4) -C(3) semi-arid vegetation transitions. Rapid Commun Mass Spectrom. 2012;26:2386-92 pubmed publisher
    ..As these changes are often accompanied by a shift from C(4) to C(3) vegetation with characteristic ?(13) C values, stable isotope analysis provides a promising mechanism for tracing these fluxes...
  34. Davicino R, Manuele M, Turner S, Ferraro G, Anesini C. Antiproliferative activity of Larrea divaricata Cav. on lymphoma cell line: participation of hydrogen peroxide in its action. Cancer Invest. 2010;28:13-22 pubmed publisher
    b>Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW5147 cells...
  35. Aranjuelo I, Ebbets A, Evans R, Tissue D, Nogués S, Van Gestel N, et al. Maintenance of C sinks sustains enhanced C assimilation during long-term exposure to elevated [CO2] in Mojave Desert shrubs. Oecologia. 2011;167:339-54 pubmed publisher
    ..responses of photosynthesis to elevated [CO(2)] were examined in two dominant Mojave Desert shrubs, the evergreen Larrea tridentata and the drought-deciduous Ambrosia dumosa, during the eighth full growing season of elevated [CO(2)] ..
  36. Davicino R, Genaro A, Cremaschi G, Anesini C. Leukotrienes antagonize the antiproliferative effect of Larrea divaricata Cav. on a lymphoma cell line interfering with cAMP intracellular level and PKC activity. Cancer Invest. 2011;29:29-36 pubmed publisher
    b>Larrea divaricata exerts a dual effect on the proliferation of BW5147 cells...
  37. Sasso C, Mattar de Anaya M, Davicino R, Martino R, Casali Y, Micalizzi B. Neutralization of Pseudomonas aeruginosa enzymatic activity by antibodies elicited with proteins of Larrea divaricata Cav. Immunopharmacol Immunotoxicol. 2012;34:346-53 pubmed publisher
    b>Larrea divaricata Cav. (Jarilla) is a bush widely used in folk therapy for the treatment of several pathologies...
  38. Lambert J, Zhao D, Meyers R, Kuester R, Timmermann B, Dorr R. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon. 2002;40:1701-8 pubmed
    b>Larrea tridentata (Moc & Sess) Cov. (Zygophyllaceae) is an ethnobotanically important plant found in the American Southwest and northern Mexico...
  39. Cane J, Minckley R, Kervin L, Roulston T, Williams N. Complex responses within a desert bee guild (Hymenoptera: Apiformes) to urban habitat fragmentation. Ecol Appl. 2006;16:632-44 pubmed
    ..These remnant patches and the surrounding desert are dominated by Larrea tridentata (creosote bush), a long-lived shrub whose flowers are visited by > 120 native bee species across its ..
  40. Joy J, Crespi B. Adaptive radiation of gall-inducing insects within a single host-plant species. Evolution. 2007;61:784-95 pubmed
    ..DNA to infer a phylogeny for 14 species of gall-inducing Asphondylia flies (Diptera: Cecidomyiidae) found on Larrea tridentata (creosote bush), which have been considered to be monophyletic based on morphological evidence...
  41. Gay M, Musser S. Single-laboratory validated method for determination of nordihydroguaiaretic acid in chaparral-containing dietary supplements. J AOAC Int. 2008;91:501-5 pubmed
    Nordihydroguaiaretic acid (NDGA) occurs naturally in chaparral (Larrea tridentate Coville), a plant which commonly grows in the Southwest United States and has been used for medicinal purposes by Native Americans indigenous to that region...
  42. Báez S, Collins S. Shrub invasion decreases diversity and alters community stability in northern Chihuahuan Desert plant communities. PLoS ONE. 2008;3:e2332 pubmed publisher
    ..In aridland ecosystems worldwide, the range of native shrubs is expanding as they invade and replace native grassland vegetation with significant consequences for biodiversity and ecosystem functioning...
  43. Abou Gazar H, Bedir E, Takamatsu S, Ferreira D, Khan I. Antioxidant lignans from Larrea tridentata. Phytochemistry. 2004;65:2499-505 pubmed
    ..E)-4,4'-dihydroxy-7,7'-dioxolign-8(8')-ene, together with 10 known compounds, were isolated from the leaves of Larrea tridentata...
  44. Toro M, Oro N, Vega A, Maturano Y, Nally M, Fernandez E, et al. [Yeast diversity in Bulnesia retama and Larrea divaricata canopies and associated soils]. Rev Argent Microbiol. 2005;37:209-13 pubmed
    ..The objective of this work was to analyzed yeast biodiversity of Bulnesia retama and Larrea divaricata canopies and associated soils, at Medanos Grandes of Caucete, San Juan, Argentina...
  45. Lambert J, Sang S, Dougherty A, Caldwell C, Meyers R, Dorr R, et al. Cytotoxic lignans from Larrea tridentata. Phytochemistry. 2005;66:811-5 pubmed
    ..the cyclolignan 3,4'-dihydroxy-3',4'-dimethoxy-6,7'-cyclolignan, were isolated from the flowering tops of Larrea tridentata...
  46. Bongiovanni G, Cantero J, Eynard A, Goleniowski M. Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with an higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel. J Exp Ther Oncol. 2008;7:1-7 pubmed
    The methanolic and methane dichloride extracts of aerial parts of Larrea divaricata Cay...
  47. Lu J, Nurko J, Jiang J, Weakley S, Lin P, Yao Q, et al. Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries. Med Sci Monit. 2011;17:BR312-318 pubmed
    ..The objective of this study was to determine if nordihydroguaiaretic acid (NDGA), a natural herbal antioxidant found in the creosote bush Larrea tridentate, can protect vascular tissues against RTV-induced vascular injury.
  48. Weber C, Zak D, Hungate B, Jackson R, Vilgalys R, Evans R, et al. Responses of soil cellulolytic fungal communities to elevated atmospheric CO? are complex and variable across five ecosystems. Environ Microbiol. 2011;13:2778-93 pubmed publisher
    ..Collectively, our results document the complexity of cellulolytic fungal communities in multiple terrestrial ecosystems and the variability of their responses to long-term exposure to elevated atmospheric CO(2)...
  49. Henderson J, Kuriata A, Fromme R, Salvucci M, Wachter R. Atomic resolution x-ray structure of the substrate recognition domain of higher plant ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase. J Biol Chem. 2011;286:35683-8 pubmed publisher
    ..Additionally, the superpositions predict that the catalytically critical Arg-293 does not interact with the bound nucleotide. Hypothetical ring-ring stacking and peptide threading models for Rubisco reactivation are briefly discussed...
  50. Martino R, Davicino R, Mattar M, Casali Y, Correa S, Micalizzi B. In vivo effect of three fractions of Larrea divaricata Cav. (jarilla) on the innate immune system: macrophage response against Candida albicans. Mycoses. 2011;54:e718-25 pubmed publisher
    b>Larrea divaricata Cav. (jarilla) is a plant with well-documented applications in folk medicine in Argentina...
  51. Estes J, Stolpman D, Olyaei A, Corless C, Ham J, Schwartz J, et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg. 2003;138:852-8 pubmed
    ..The use of potentially hepatotoxic herbal and dietary supplements is highly prevalent in the fulminant hepatic failure (FHF) patient population at our institution, and this subgroup of patients has a worse prognosis...
  52. Kohl K, Dearing M. Induced and constitutive responses of digestive enzymes to plant toxins in an herbivorous mammal. J Exp Biol. 2011;214:4133-40 pubmed publisher
    ..Neotoma bryanti) that vary in their ecological and evolutionary experience with the PSCs in creosote bush (Larrea tridentata) were compared...
  53. Martino R, Canale F, Sülsen V, Alonso R, Davicino R, Mattar A, et al. A fraction containing kaempferol-3,4'-dimethylether from Larrea divaricata Cav. induces macrophage activation on mice infected with Candida albicans. Phytother Res. 2014;28:917-24 pubmed publisher
    b>Larrea divaricata Cav. is a plant growing in South America. Both the infusion and a derived fraction (F1) of L.?divaricata have proved to have immunomodulatory properties...
  54. Favela Hernández J, Garcia A, Garza Gonzalez E, Rivas Galindo V, Camacho Corona M. Antibacterial and antimycobacterial lignans and flavonoids from Larrea tridentata. Phytother Res. 2012;26:1957-60 pubmed publisher
    Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains...
  55. de Anaya M, Davicino R, Casali Y, Correa S, Micalizzi B. Cross-reaction between proteins of Larrea divaricata Cav. (jarilla) and proteins of Gram-negative bacteria. Immunopharmacol Immunotoxicol. 2009;31:654-60 pubmed publisher
    b>Larrea divaricata is an abundant plant of northwest of Argentina used to treat different pathologies. We aimed to characterize the immunogenicity of proteins from a partially purified crude aqueous extract (JPCE) of jarilla...
  56. Davicino R, Alonso R, Anesini C. 'In vivo' and 'in vitro' activity of Larrea divaricata Cav. on EL-4 cells. Hum Exp Toxicol. 2011;30:965-71 pubmed publisher
    b>Larrea divaricata is a plant widely used in folk medicine in Argentina. It has been demonstrated that an aqueous extract of L...
  57. Minckley R, Cane J, Kervin L. Origins and ecological consequences of pollen specialization among desert bees. Proc Biol Sci. 2000;267:265-71 pubmed
    ..historical biogeography (20,000 years before present to the present) of the desert-limited plant, creosote bush (Larrea tridentata), is remarkably complete...
  58. Kim S, Vassão D, Moinuddin S, Bedgar D, Davin L, Lewis N. Allyl/propenyl phenol synthases from the creosote bush and engineering production of specialty/commodity chemicals, eugenol/isoeugenol, in Escherichia coli. Arch Biochem Biophys. 2014;541:37-46 pubmed publisher
    The creosote bush (Larrea tridentata) harbors members of the monolignol acyltransferase, allylphenol synthase, and propenylphenol synthase gene families, whose products together are able to catalyze distinct regiospecific conversions of ..
  59. Bashyal B, Li L, Bains T, Debnath A, Labarbera D. Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri. PLoS Negl Trop Dis. 2017;11:e0005832 pubmed publisher
    ..lamblia, E. histolytica, and N. fowleri. Herein, we report Larrea tridentata, known as creosote bush, as a novel source for secondary metabolites that display antiparasitic ..
  60. Sorensen J, Heward E, Dearing M. Plant secondary metabolites alter the feeding patterns of a mammalian herbivore (Neotoma lepida). Oecologia. 2005;146:415-22 pubmed
    ..the herbivorous desert woodrat (Neotoma lepida) fed diets containing phenolic resin extracted from creosote bush (Larrea tridentata)...
  61. Guzmán Beltrán S, Pedraza Chaverri J, González Reyes S, Hernández Sánchez F, Juarez Figueroa U, Gonzalez Y, et al. Nordihydroguaiaretic acid attenuates the oxidative stress-induced decrease of CD33 expression in human monocytes. Oxid Med Cell Longev. 2013;2013:375893 pubmed publisher
    ..acid (NDGA) is a natural lignan with recognized antioxidant and beneficial properties that is isolated from Larrea tridentata...
  62. Remya C, Dileep K, Tintu I, Variyar E, Sadasivan C. In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile. J Mol Model. 2013;19:1179-94 pubmed publisher
    ..The studies revealed that some of the designed compounds can be used as lead molecules for the development of drugs against AD...
  63. Vassão D, Kim S, Milhollan J, Eichinger D, Davin L, Lewis N. A pinoresinol-lariciresinol reductase homologue from the creosote bush (Larrea tridentata) catalyzes the efficient in vitro conversion of p-coumaryl/coniferyl alcohol esters into the allylphenols chavicol/eugenol, but not the propenylphenols p-anol/i. Arch Biochem Biophys. 2007;465:209-18 pubmed
    The creosote bush (Larrea tridentata) accumulates a complex mixture of 8-8' regiospecifically linked lignans, of which the potent antioxidant nordihydroguaiaretic acid (NDGA) is the most abundant...
  64. Ventura J, Gutierrez Sanchez G, Rodríguez Herrera R, Aguilar C. Fungal cultures of tar bush and creosote bush for production of two phenolic antioxidants (pyrocatechol and gallic acid). Folia Microbiol (Praha). 2009;54:199-203 pubmed publisher
    ..Biotransformation of tannins to gallic acid was high (93 % in creosote bush and 89 % in tar bush). Pyrocatechol was released poorly. Kinetic parameters of tannin conversion were calculated...
  65. Bigliani M, Grondona E, Zunino P, Ponce A. Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice. Hum Exp Toxicol. 2010;29:601-6 pubmed publisher
    Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0...
  66. Davicino R, Mattar A, Casali Y, Porporatto C, Correa S, Micalizzi B. In vivo immunomodulatory effects of aqueous extracts of Larrea divaricata Cav. Immunopharmacol Immunotoxicol. 2007;29:351-66 pubmed
    ..b>Larrea divaricata Cav...
  67. Jorquera M, Shaharoona B, Nadeem S, de la Luz Mora M, Crowley D. Plant growth-promoting rhizobacteria associated with ancient clones of creosote bush (Larrea tridentata). Microb Ecol. 2012;64:1008-17 pubmed publisher
    ..Here, we examined rhizobacteria associated with ancient clones of Larrea tridentata in the Mohave desert, including the 11,700-year-old King Clone, which is oldest known specimen of this ..
  68. Yokosuka A, Matsuo Y, Jitsuno M, Adachi K, Mimaki Y. Larrealignans A and B, novel lignan glycosides from the aerial parts of Larrea tridentata. Chem Pharm Bull (Tokyo). 2011;59:1467-70 pubmed
    ..glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae)...
  69. Medeiros J, Marshall D, Maherali H, Pockman W. Variation in seedling freezing response is associated with climate in Larrea. Oecologia. 2012;169:73-84 pubmed publisher
    ..severity is hypothesized to have influenced the distribution and evolution of the warm desert evergreen genus Larrea. If this hypothesis is correct, performance and survival of species and populations should vary predictably along ..
  70. Meckes M, David Rivera A, Nava Aguilar V, Jimenez A. Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Phytomedicine. 2004;11:446-51 pubmed
    ..Oenothera rosea methanol extract, Sphaeralcea angustifolia chloroform extract, Acaciafarnesiana, Larrea tridentata and Rubus coriifolius methanol extracts as well as the aqueous extract of Chamaedora tepejilote were ..
  71. Davicino R, Martinez C, Mattar M, Casali Y, Correa S, Aragon L, et al. Larrea divaricata Cav (Jarilla): production of superoxide anion, hydrogen peroxide and expression of zymosan receptors. Immunopharmacol Immunotoxicol. 2008;30:489-501 pubmed
    b>Larrea divaricata is a plant widely used in folk medicine in Argentina. This work aimed to study the mechanisms of decoction activity on the release of oxygen reactive species...
  72. Esque T, Kaye J, Eckert S, Defalco L, Tracy C. Short-term soil inorganic N pulse after experimental fire alters invasive and native annual plant production in a Mojave Desert shrubland. Oecologia. 2010;164:253-63 pubmed publisher