stemonaceae

Summary

Summary: A small plant family of the order Liliales, subclass Liliidae, class Liliopsida (monocotyledons).

Top Publications

  1. Li E, Yi S, Qiu Y, Guo J, Comes H, Fu C. Phylogeography of two East Asian species in Croomia (Stemonaceae) inferred from chloroplast DNA and ISSR fingerprinting variation. Mol Phylogenet Evol. 2008;49:702-14 pubmed publisher
    The genus Croomia (Stemonaceae) comprises three herbaceous perennial species that are distributed in temperate-deciduous forests in Southeastern North America (C.pauciflora) and East Asia (C. japonica, C. heterosepala)...
  2. Greger H, Schinnerl J, Vajrodaya S, Brecker L, Hofer O. Pandanus alkaloids in Stemonaceae: finding of a plausible biogenetic origin of Stemona alkaloids. J Nat Prod. 2009;72:1708-11 pubmed publisher
    ..corresponding isomers (Z,E)-pandanamine (2) and (E,E)-pandanamine (3) from Stichoneuron calcicola of the family Stemonaceae is of outstanding chemosystematic importance...
  3. Umsumarng S, Pitchakarn P, Yodkeeree S, Punfa W, Mapoung S, Ramli R, et al. Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships. Phytomedicine. 2017;34:182-190 pubmed publisher
    ..This study investigated whether other Stemona alkaloids that had been purified from Stemonaceae plants exerted MDR modulation activity...
  4. Liao J, Qin S, Qu X, Lin K, Huang D, Li F, et al. [Comparative study of four alkaloids contents and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province]. Zhong Yao Cai. 2014;37:1956-60 pubmed
    ..Stemonae Radix from Dongxing, Fangcheng can reduce cough times and prolong cough incubation period, and thus Dongxing, Fangcheng is the best habitat in Guangxi in the present experiments. ..
  5. Leung P, Zhang L, Zuo Z, Lin G. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006;72:211-6 pubmed
    ..Cyclosporin A dose-dependently inhibited the secretory permeability of these alkaloids and abolished their active efflux transport. ..
  6. Chen Z, Zhang Y, Chen Z, Tu Y, Zhang F. Total synthesis of (±)-maistemonine and (±)-stemonamide. Chem Commun (Camb). 2011;47:1836-8 pubmed publisher
    ..Additionally, another Stemona alkaloid stemonamide was divergently synthesized from a common intermediate. ..
  7. Hu J, Zhang N, Mao Y, Yang D, Tan H, Ni S, et al. [Antitussive activity comparison of three kinds of Stemonae Radix in Chinese Pharmacopoeia]. Zhongguo Zhong Yao Za Zhi. 2009;34:3096-104 pubmed
    ..The antitussive efficacies of Stemonae Radix were influenced by chemical diversity both in same species and among different species, different fractions and processed method. ..
  8. Kongkiatpaiboon S, Schinnerl J, Felsinger S, Keeratinijakal V, Vajrodaya S, Gritsanapan W, et al. Structural relationships of stemona alkaloids: assessment of species-specific accumulation trends for exploiting their biological activities. J Nat Prod. 2011;74:1931-8 pubmed publisher
    ..Further diversification within this structural type results from a mutual accumulation of derivatives with a pyrrolo- or pyridoazepine nucleus, leading to chemical variability in S. curtisii and S. aphylla. ..
  9. Pilli R, Rosso G, de Oliveira M. The stemona alkaloids. Alkaloids Chem Biol. 2005;62:77-173 pubmed

More Information

Publications87

  1. Lin L, Yang X, Tang C, Ke C, Zhang J, Ye Y. Antibacterial stilbenoids from the roots of Stemona tuberosa. Phytochemistry. 2008;69:457-63 pubmed
    ..Dihydrostilbene 8 exhibited strong activity against Bacillus pumilus (MIT 12.5-25 microg/mL). Many tested compounds exhibited moderate antibacterial activities. ..
  2. Liu X, Ye J, Ruan Y, Li Y, Huang P. Total synthesis of (-)-sessilifoliamide J. J Org Chem. 2013;78:35-41 pubmed publisher
    ..7% overall yield from the known building block 8 is presented. The synthesis features the Corey lactonization reaction and a highly diastereoselective ?-methylation reaction to build the spiro-lactone moiety. ..
  3. Pilli R, Rosso G, de Oliveira M. The chemistry of Stemona alkaloids: An update. Nat Prod Rep. 2010;27:1908-37 pubmed publisher
  4. Tasanor O, Engelmeier D, Brem B, Wiedermann Schmidt U, Greger H, Wernsdorfer W. Development of a pharmacodynamic screening model with Crithidia fasciculata. Wien Klin Wochenschr. 2006;118:42-9 pubmed
    ..Encouraging results were obtained with extracts from Aglaia odorata leaves, A. elaeagnoidea stem bark and A. edulis leaves, with EC(90) values of 1213 ng/ml, 1606 ng/ml, and 1462 ng/ml, respectively...
  5. Chen Z, Tu Y, Zhang S, Zhang F. Development of the intramolecular Prins cyclization/Schmidt reaction for the construction of the azaspiro[4,4]nonane: application to the formal synthesis of (±)-stemonamine. Org Lett. 2011;13:724-7 pubmed publisher
    ..The present tandem protocol has been employed to construct the tricyclic azaquaternary skeleton (ring A, B, and C) of stemonamine. ..
  6. Khim S, Schultz A. Synthesis of (-)-9,10-epi-stemoamide. J Org Chem. 2004;69:7734-6 pubmed
    ..An efficient synthesis of (-)-9,10-epi-stemoamide has been accomplished in nine steps and 13% overall yield. The synthesis features a lithium hydroxide-promoted fragmentation and an intramolecular 7-exo-trig radical cyclization. ..
  7. Greger H. Structural relationships, distribution and biological activities of stemona alkaloids. Planta Med. 2006;72:99-113 pubmed
    ..alkaloids represent a unique class of natural products exclusively isolated from the monocotyledonous family Stemonaceae comprising three genera mainly distributed in southeast Asia...
  8. Mungkornasawakul P, Pyne S, Jatisatienr A, Supyen D, Jatisatienr C, Lie W, et al. Phytochemical and larvicidal studies on Stemona curtisii: structure of a new pyrido[1,2-a]azepine Stemona alkaloid. J Nat Prod. 2004;67:675-7 pubmed
    ..The individual alkaloid components showed significant larvicidal activity (IC(50) 4-39 ppm) on mosquito larvae (Anopheles minimus HO). ..
  9. Chen Z, Chen Z, Zhang Y, Tu Y, Zhang F. Total synthesis of (±)-maistemonine, (±)-stemonamide, and (±)-isomaistemonine. J Org Chem. 2011;76:10173-86 pubmed publisher
    ..Moreover, (±)-stemonamide was divergently synthesized from a common intermediate, and (±)-isomaistemonine was obtained via the epimerization of (±)-maistemonine at C-12. ..
  10. Lu F, Sun L, Lu Z, Bie X, Fang Y, Liu S. Isolation and identification of an endophytic strain EJS-3 producing novel fibrinolytic enzymes. Curr Microbiol. 2007;54:435-9 pubmed
    ..No work on P. polymyxa-producing fibrinolytic enzymes has been reported. ..
  11. Brüggemann M, McDonald A, Overman L, Rosen M, Schwink L, Scott J. Total synthesis of (+/-)-didehydrostemofoline (asparagamine A) and (+/-)-isodidehydrostemofoline. J Am Chem Soc. 2003;125:15284-5 pubmed
    ..2.1]heptanol 14. Aza-Cope-Mannich reaction of the formaldiminium derivative of 14 delivers 1-azatricyclo[5.3.0.04.10]decane 15, which in 15 additional steps is converted to 1 and 3. ..
  12. Zhou Y, Jiang R, Hon P, Xu Y, Chan Y, Chan T, et al. Analyses of Stemona alkaloids in Stemona tuberosa by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20:1030-8 pubmed
    ..japonica and S. sessilifolia, as all three species are recognized as genuine sources of the herb Radix Stemonae in the Pharmacopoeia of the People's Republic of China. ..
  13. Roberts E, Sançon J, Sweeney J. A new class of ammonium ylid for [2,3]-sigmatropic rearrangement reactions: ene-endo-spiro ylids. Org Lett. 2005;7:2075-8 pubmed
    ..6]-ylids rearrange by [1,2]- and [2,3]-mechanisms in roughly equal proportions. This method serves as a rapid entry to the core of a range of alkaloids bearing a pyrrolo[1,2-a]azepine or octahydroindolizidine nucleus. ..
  14. Wang Y, Tang C, Dien P, Ye Y. Alkaloids from the roots of Stemona saxorum. J Nat Prod. 2007;70:1356-9 pubmed
    ..The structures of these alkaloids were characterized on the basis of spectroscopic methods. ..
  15. Padwa A, Ginn J. Studies on the synthesis of (+/-)-stenine: a combined intramolecular [4 + 2]-cycloaddition/rearrangement cascade. J Org Chem. 2005;70:5197-206 pubmed
    ..Compound 10 was converted to stenine in 11 additional steps via a sequence that features a Crabtree's-catalyst directed hydrogenation, iodolactonization, and a Keck allylation. ..
  16. Mungkornasawakul P, Pyne S, Jatisatienr A, Supyen D, Lie W, Ung A, et al. Stemocurtisine, the first pyrido[1,2-a]azapine Stemona alkaloid. J Nat Prod. 2003;66:980-2 pubmed
    ..The structure and relative stereochemistry was determined by spectral data interpretation and X-ray crystallography. ..
  17. Hosoya T, Yamasaki F, Nakata A, Rahman A, Kusumawati I, Zaini N, et al. Inhibitors of nitric oxide production from Stemona javanica. Planta Med. 2011;77:256-8 pubmed publisher
    ..The inhibition mechanism of 1 was proposed to suppress iNOS expression in J774.1 cells stimulated by LPS, whereas that of 2 was due to potent radical scavenging activity resulting in NO inhibitory activity. ..
  18. Sastraruji T, Chaiyong S, Jatisatienr A, Pyne S, Ung A, Lie W. Phytochemical studies on Stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans. J Nat Prod. 2011;74:60-4 pubmed publisher
    ..Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities. Three of these showed antibacterial activities against MRSA with MIC values of 15.6 ?g/mL...
  19. Zhang T, Zhang Y, Tao J. Antibacterial constituents from Stemona sessilifolia. J Asian Nat Prod Res. 2007;9:479-85 pubmed
    ..Compounds 5, 6, and 8 exhibited strong antibacterial activities against Staphylococcus aureus and S. epidermidis...
  20. Sastraruji T, Jatisatienr A, Pyne S, Ung A, Lie W, Williams M. Phytochemical studies on Stemona plants: isolation of stemofoline alkaloids. J Nat Prod. 2005;68:1763-7 pubmed
    ..The structure and relative configuration of these new alkaloids have been determined by spectral data interpretation and from semisynthetic studies...
  21. Frankowski K, Setola V, Evans J, Neuenswander B, Roth B, AUBE J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proc Natl Acad Sci U S A. 2011;108:6727-32 pubmed publisher
    ..This collaborative effort combined the development of synthetic methods with extensive, flexible screening resources and exemplifies the role of natural products in bioactivity mining...
  22. Kostecki K, Engelmeier D, Pacher T, Hofer O, Vajrodaya S, Greger H. Dihydrophenanthrenes and other antifungal stilbenoids from Stemona cf. pierrei. Phytochemistry. 2004;65:99-106 pubmed
    ..Because of weak inhibition and chemical instability of stemanthrenes, no EC(50) and EC(90) values could be calculated...
  23. Han L, Ma Y, An L, Zhang Q, Wang C, Zhao Q. Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells. Nat Prod Res. 2016;30:1186-9 pubmed publisher
    ..sessilifolia plays an important role in reversing MDR of cancer as a P-gp modulator in vitro and may be effective in the treatment of multidrug-resistant cancers. ..
  24. Zhao Y, Gu P, Tu Y, Fan C, Zhang Q. An efficient total synthesis of (+/-)-stemonamine. Org Lett. 2008;10:1763-6 pubmed publisher
    ..An efficient first approach to the Stemona alkaloid (+/-)-Stemonamine has been developed on the basis of a key TiCl4 promoted tandem Semipinacol rearrangement/Schmidt reaction and a Dieckmann condensation reaction...
  25. Guo A, Jin L, Deng Z, Cai S, Guo S, Lin W. New stemona alkaloids from the roots of Stemona sessilifolia. Chem Biodivers. 2008;5:598-605 pubmed publisher
    ..Isooxymaistemonine (2) showed a positive effect on the human high-density lipoprotein (HDL) receptor gene CD36 and LIMP II analogous-1 (CLA-1) at the dosage of 10 microg/ml...
  26. Kongkiatpaiboon S, Keeratinijakal V, Gritsanapan W. Simultaneous quantification of stemocurtisine, stemocurtisinol and stemofoline in Stemona curtisii (Stemonaceae) by TLC-densitometric method. J Chromatogr Sci. 2013;51:430-5 pubmed publisher
    Stemona curtisii Hook. F. (Family Stemonaceae), a prominent species distributed in the south and southwest of Thailand, has widely been used as a natural pesticide and as treatment for head lice and skin diseases...
  27. Wang P, Liu A, An Z, Li Z, Du G, Qin H. Novel alkaloids from the roots of Stemona sessilifolia. Chem Biodivers. 2007;4:523-30 pubmed
    ..Compounds 1 and 2 were found to be moderately active in terms of acetylcholinesterase (AchE) inhibition, with IC50 values of 68.8+/-9.5 and 17.1+/-2.5 microM, resp...
  28. Yuan J, Pu Y, Zhang T, Tao J, Wu T, Lu H. [Technology study on extraction and purification of alkaloid from Stemona japonica]. Zhong Yao Cai. 2011;34:126-9 pubmed
    ..In order to obtain the optimal conditions for separating the alkaloids from the extract of Stemona japonica by selecting appropriate cation exchange resins...
  29. Burrell A, Watson L, Martin N, Oram N, Coldham I. Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular cycloaddition. Org Biomol Chem. 2010;8:4530-2 pubmed publisher
  30. Kongkiatpaiboon S, Pattarajinda V, Keeratinijakal V, Gritsanapan W. Effect of Stemona spp. against Rhipicephalus microplus. Exp Appl Acarol. 2014;62:115-20 pubmed publisher
    ..The results confirmed traditional use of S. collinsiae as a better source of insecticide than other species and could be used as guidance for further development of S. collinsiae as a herbal acaricide...
  31. Astelbauer F, Obwaller A, Raninger A, Brem B, Greger H, Duchene M, et al. Anti-leishmanial activity of plant-derived acridones, flavaglines, and sulfur-containing amides. Vector Borne Zoonotic Dis. 2011;11:793-8 pubmed publisher
    ..None of the compounds showed hemolytic activity...
  32. Sastraruji K, Sastraruji T, Pyne S, Ung A, Jatisatienr A, Lie W. Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues. J Nat Prod. 2010;73:935-41 pubmed publisher
    ..1'S)-Hydroxystemofoline (10) and a number of related analogues were also prepared. In a TLC bioautographic assay, 9 was found to be the most active acetylcholinesterase inhibitor, but it was not as active as galanthamine...
  33. Wang F, Chen Q. Stemona alkaloids: biosynthesis, classification, and biogenetic relationships. Nat Prod Commun. 2014;9:1809-22 pubmed
    ..Based on the comprehensive consideration of biogenetic pathways and chemical features, the 183 Stemona alkaloids are classified into two classes (hemiterpenoid pyrrolidine- and monoterpenoid pyrrolidine) and fourteen types...
  34. Sanguanpong U, Hummel H. Toxicity of Stemona root against onion cutworm by using different contacting methods and solvents. Commun Agric Appl Biol Sci. 2008;73:459-67 pubmed
    ..On the other hand, hexane extract caused approximately 30 % mortality with highest concentration at 15% w/w. Dichloromethane and acetone extract could be considered of similar efficiency...
  35. Dong W, Wang P, Meng X, Sun H, Zhang A, Wang W, et al. Ultra-performance liquid chromatography-high-definition mass spectrometry analysis of constituents in the root of Radix Stemonae and those absorbed in blood after oral administration of the extract of the crude drug. Phytochem Anal. 2012;23:657-67 pubmed publisher
    ..Current analysis methods are usually time-consuming and inaccurate...
  36. Ge F, Ke C, Tang W, Yang X, Tang C, Qin G, et al. Isolation of chlorogenic acids and their derivatives from Stemona japonica by preparative HPLC and evaluation of their anti-AIV (H5N1) activity in vitro. Phytochem Anal. 2007;18:213-8 pubmed
    ..The anti-AIV (H5N1) activities were evaluated by Neutral Red uptake assay. Compounds 3 and 4 exerted moderate inhibitory effect against AIV (H5N1) in vitro...
  37. Lee K, Sung S, Kim Y. Neuroprotective bibenzyl glycosides of Stemona tuberosa roots. J Nat Prod. 2006;69:679-81 pubmed
    ..All three bibenzyl glycosides significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity...
  38. Yang X, Tang C, Ke C, Ye Y. Stilbenoids from Stemona sessilifolia. J Asian Nat Prod Res. 2007;9:261-6 pubmed
    ..Structures of new stilbenoids were established by 1D and 2D (1)H NMR and (13)C NMR spectroscopic analyses...
  39. Zhang Y, Xu G, Zhang T. Antifungal stilbenoids from Stemona japonica. J Asian Nat Prod Res. 2008;10:639-44 pubmed publisher
    ..Their structures were elucidated by spectroscopic analyses. Compounds 5 and 6 exhibited strong antifungal activities against Candida albicans...
  40. Tang C, Chen T, Velten R, Jeschke P, Ebbinghaus Kintscher U, Geibel S, et al. Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities. J Nat Prod. 2008;71:112-6 pubmed publisher
  41. Chanmahasathien W, Ampasavate C, Greger H, Limtrakul P. Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance. Phytomedicine. 2011;18:199-204 pubmed publisher
    ..This is the first report of new pharmacological activity of Stemona alkaloids, which could be a new potential MDR chemosensitizer...
  42. Kongkiatpaiboon S, Gritsanapan W. HPLC quantitative analysis of insecticidal didehydrostemofoline and stemofoline in Stemona collinsiae root extracts. Phytochem Anal. 2012;23:554-8 pubmed publisher
    ..Stemona collinsiae Craib has been of interest for its insecticidal activity, which has been supported by many scientific research studies. The roots contain didehydrostemofoline and stemofoline alkaloids as active components...
  43. Fukaya H, Hitotsuyanagi Y, Aoyagi Y, Shu Z, Komatsu K, Takeya K. Absolute structures of stemona-lactam S and tuberostemospiroline, alkaloids from stemona tuberosa. Chem Pharm Bull (Tokyo). 2013;61:1085-9 pubmed
    ..b>Stemonaceae)...
  44. Limtrakul P, Siwanon S, Yodkeeree S, Duangrat C. Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells. Phytomedicine. 2007;14:381-9 pubmed
    ..This is the first report of new biological activity in this plant, which could be a potential source of a new chemosensitizer...
  45. Tian Y, Li C, Deng Y. [Anti-mite activity and skin safety of Herbal taraxaci extract for Demodex folliculorum]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007;25:133-6 pubmed
    ..To test the in vitro effect of the extract of Herbal taraxaci on Demodex folliculorum...
  46. Fujioka H, Nakahara K, Kotoku N, Ohba Y, Nagatomi Y, Wang T, et al. Asymmetric total synthesis of (-)-stenine and 9a-epi-stenine. Chemistry. 2012;18:13861-70 pubmed publisher
    ..The results of this effort demonstrate the applicability of the chiral auxiliary based strategy to the preparation of naturally occurring alkaloids that contain highly functionalized cyclohexane cores...
  47. Sun H, Dong W, Zhang A, Wang W, Wang X. Ultra-performance liquid-chromatography with tandem mass spectrometry performing pharmacokinetic and biodistribution studies of croomine, neotuberostemonine and tuberostemonine alkaloids absorbed in the rat plasma after oral administration of Stemona. Fitoterapia. 2012;83:1699-705 pubmed publisher
    ..This work suggests that the pharmacokinetics and biodistribution based-UPLC-Q-TOF-HDMS can provide a reliable tools for screening bioactive components contributing to pharmacological effects of medicinal herbs...
  48. Yue Y, Deng A, Xu D, Qin H. Two new stemona alkaloids from Stemona tuberosa Lour. J Asian Nat Prod Res. 2013;15:145-50 pubmed publisher
    ..The structures and relative configurations of new compounds were established on the basis of extensive spectroscopic evidences, especially 1D and 2D NMR and HR-MS experiments...
  49. Lai D, Yang Z, Xue W, Sheng J, Shi Y, Yao X. Isolation, characterization and acetylcholinesterase inhibitory activity of alkaloids from roots of Stemona sessilifolia. Fitoterapia. 2013;89:257-64 pubmed publisher
    ..2 ?M and 19.8±2.5 ?M, resp. The mode of AChE inhibition by Compound 2 (the most potential AChE inhibitor) was reversible and competitive. In addition, molecular modeling was performed to explore the binding mode of compound 2 with AChE...
  50. Chung H, Hon P, Lin G, But P, Dong H. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 2003;69:914-20 pubmed
  51. Peng S, Shi T, Wang Y, Lin L, Yang Y, Jiang H, et al. Rapid structural determination of alkaloids in a crude extract of Stemona saxorum by high-performance liquid chromatography/electrospray ionization coupled with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2009;23:3621-31 pubmed publisher
    ..This method is convenient and sensitive, especially for minor components in complex natural product extracts...
  52. Adams M, Pacher T, Greger H, Bauer R. Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species. J Nat Prod. 2005;68:83-5 pubmed
    ..7 to >50 microM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 microM...
  53. Baird M, Pyne S, Ung A, Lie W, Sastraruji T, Jatisatienr A, et al. Semisynthesis and biological activity of stemofoline alkaloids. J Nat Prod. 2009;72:679-84 pubmed publisher
    ..In a quantitative assay as AChE inhibitors, (11Z)-1',2'-didehydrostemofoline (4) and (3'S)-hydroxystemofoline (5) were found to be the most active...
  54. Hoye A, Wipf P. Total synthesis of (-)-sessilifoliamide C and (-)-8-epi-stemoamide. Org Lett. 2011;13:2634-7 pubmed publisher
    ..In addition to the first total synthesis of (-)-sessilifoliamide C, a potential biosynthetic relationship between the sessilifoliamides and previously reported Stemona alkaloids is presented...
  55. Liu X, Wang F. Recent Advances in the Synthesis of Stemona Alkaloids. Nat Prod Commun. 2015;10:1093-102 pubmed
    ..alkaloids, featuring polycyclic structures and interesting bioactivities, constitute a distinct class from the Stemonaceae family...
  56. Cai X, Luo X. Alkaloids from Stemona mairei. Planta Med. 2007;73:170-3 pubmed
  57. Sturm S, Schinnerl J, Greger H, Stuppner H. Nonaqueous capillary electrophoresis-electrospray ionization-ion trap-mass spectrometry analysis of pyrrolo- and pyrido[1,2-a]azepine alkaloids in Stemona. Electrophoresis. 2008;29:2079-87 pubmed publisher
    ..5 microg/mL, LOQs <25.0 microg/mL, for all analytes, recovery rates >98.9%) in several Stemona sp. extracts...
  58. Sun H, Dong W, Zhang A, Wang W, Wang X. Pharmacokinetics study of multiple components absorbed in rat plasma after oral administration of Stemonae radix using ultra-performance liquid-chromatography/mass spectrometry with automated MetaboLynx software analysis. J Sep Sci. 2012;35:3477-85 pubmed publisher
  59. Dheeranupattana S, Sangthong P, Roytrakul S, Chaichana N. Proteomic profiling of Stemona alkaloids production response to chitosan elicitor. Pak J Biol Sci. 2013;16:950-4 pubmed
    ..Thus, Stemona alkaloids may be responsive to this stress...
  60. Taniguchi T, Tanabe G, Muraoka O, Ishibashi H. Total synthesis of (+/-)-stemonamide and (+/-)-isostemonamide using a radical cascade. Org Lett. 2008;10:197-9 pubmed
    ..Total synthesis of stemonamide and isostemonamide is described. The concise construction of the tricyclic core of these alkaloids was achieved by radical cascade involving 7-endo and 5-endo cyclizations...
  61. Lainchbury M, Medley M, Taylor P, Hirst P, Dohle W, Booker Milburn K. A protecting group free synthesis of (+/-)-neostenine via the [5 + 2] photocycloaddition of maleimides. J Org Chem. 2008;73:6497-505 pubmed publisher
    ..The synthesis was completed in 14 steps from furan, in 9.5% overall yield, without the use of any protecting groups...
  62. Jiang D, Yang X, Liu H, Guan H. Development and validation of a high-performance liquid chromatographic method for the determination of stemoninine in rat plasma after administration of Stemona tuberosa extracts. Biomed Chromatogr. 2011;25:498-502 pubmed publisher
    ..Intra- and inter-batch coefficient of variations were 3.27-5.37% and 2.49-3.92%, respectively. This method was successfully applied to pharmacokinetic studies after oral and intravenous administration of Stemona tuberosa extract in rats...
  63. Kongkiatpaiboon S, Keeratinijakal V, Gritsanapan W. HPLC analysis of stemokerrine and oxystemokerrine in the Thai medicinal plant Stemona kerrii. Nat Prod Commun. 2012;7:1277-8 pubmed
    ..2 and 0.05%, w/w, respectively. The present work will provide a useful standardization method for S. kerrii raw materials for further pharmaceutical development...
  64. Mungkornasawakul P, Pyne S, Jatisatienr A, Lie W, Ung A, Issakul K, et al. Phytochemical studies on Stemona burkillii prain: two new dihydrostemofoline alkaloids. J Nat Prod. 2004;67:1740-3 pubmed
    ..The configuration of the exo-cyclic alkene group in 4 is tentively assigned as E on the basis of mechanistic considerations...
  65. Kongkiatpaiboon S, Keeratinijakal V, Gritsanapan W. TLC-image analysis of non-chromophoric tuberostemonine alkaloid derivatives in Stemona species. Nat Prod Commun. 2013;8:1065-8 pubmed
    ..phyllantha roots contained 1.39 +/- 0.14% tuberostemonine and 0.39 +/- 0.08% tuberostemonine A (dry weight). The proposed method was simple, inexpensive, and more accessible to apply for many local authorities and small laboratories...
  66. Li S, Jiang R, Hon P, Cheng L, Xu H, Greger H, et al. Quality evaluation of Radix Stemonae through simultaneous quantification of bioactive alkaloids by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. Biomed Chromatogr. 2007;21:1088-94 pubmed
    ..This simple, rapid, low-cost and reliable method is suitable for the routine quality control of herbal medicines containing bioactive components with different structure types such as Radix Stemonae...
  67. Sastraruji K, Pyne S, Ung A, Mungkornasawakul P, Lie W, Jatisatienr A. Structural revision of stemoburkilline from an E-alkene to a Z-alkene. J Nat Prod. 2009;72:316-8 pubmed publisher
    ..A re-examination of the crude root extracts of Stemona burkillii Prain and further NOE studies established stemoburkilline as the Z-isomer (8)...
  68. Zhou X, Leung P, Li N, Ye Y, Zhang L, Zuo Z, et al. Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa. Planta Med. 2009;75:575-80 pubmed publisher
    ..Alkaloid 4 demonstrated a moderate permeability in Caco-2 monolayer cells while alkaloids 1, 2 and 3 exhibited relatively higher intestinal permeabilities, indicating that all four alkaloids tested had reasonable oral absorption...
  69. Fan L, Zhu S, Chen H, Yang D, Cai S, Komatsu K. Molecular analysis of Stemona plants in China based on sequences of four chloroplast DNA regions. Biol Pharm Bull. 2009;32:1439-46 pubmed
  70. Chanmahasathien W, Ohnuma S, Ambudkar S, Limtrakul P. Biochemical mechanism of modulation of human P-glycoprotein by stemofoline. Planta Med. 2011;77:1990-5 pubmed publisher
    ..Taken together, the results exhibit that stemofoline possesses an effective MDR modulator, and may be used in combination with conventional chemotherapeutic drugs to reverse MDR in cancer cells...
  71. Greger H. The diversity of Stemona stilbenoids as a result of storage and fungal infection. J Nat Prod. 2012;75:2261-8 pubmed publisher
    ..Potential neuroprotective activities have been reported for three dihydrostilbene glucosides against 6-hydroxydopamine-induced neurotoxicity in human neuroblastoma SH-SY5Y cells...
  72. Schinnerl J, Brem B, But P, Vajrodaya S, Hofer O, Greger H. Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species. Phytochemistry. 2007;68:1417-27 pubmed
    ..A new stereoisomer of tuberostemonine was isolated and identified by spectroscopic methods...
  73. Bardají N, Sánchez Izquierdo F, Alibés R, Font J, Busqué F, Figueredo M. Flexible approach to stemona alkaloids: total syntheses of (-)-stemospironine and three new diastereoisomeric analogs. Org Lett. 2012;14:4854-7 pubmed
    ..The configuration of the stereogenic center at C-11 was controlled by fine-tuning of the synthetic sequence...
  74. Yang X, Tang C, Ye Y. Stilbenoids from Stemona japonica. J Asian Nat Prod Res. 2006;8:47-53 pubmed
    ..Their structures were elucidated by spectroscopic analyses. Compounds 3-6 exhibited strong antibacterial activities against Staphylococcus aureus and Staphylococcus epidermidis...
  75. Xu Y, Shaw P, Jiang R, Hon P, Chan Y, But P. Antitussive and central respiratory depressant effects of Stemona tuberosa. J Ethnopharmacol. 2010;128:679-84 pubmed publisher
    ..This study aims to determine if alkaloids of this herb contribute equally to the antitussive functions, act on the same sites of cough reflex, and play any role in inducing central respiratory depressant effects...
  76. Brem B, Seger C, Pacher T, Hartl M, Hadacek F, Hofer O, et al. Antioxidant dehydrotocopherols as a new chemical character of Stemona species. Phytochemistry. 2004;65:2719-29 pubmed
  77. Kumeta Y, Maruyama T, Wakana D, Kamakura H, Goda Y. Chemical analysis reveals the botanical origin of shatavari products and confirms the absence of alkaloid asparagamine A in Asparagus racemosus. J Nat Med. 2013;67:168-73 pubmed publisher
    ..racemosus does not contain asparagamine A, and that previous isolation of asparagamine A from materials claimed as originating from A. racemosus was likely caused by misidentification of Stemona plants as A. racemosus...
  78. Fan L, Zhu S, Chen H, Yang D, Cai S, Komatsu K. Identification of the botanical source of stemonae radix based on polymerase chain reaction with specific primers and polymerase chain reaction-restriction fragment length polymorphism. Biol Pharm Bull. 2009;32:1624-7 pubmed