solanum glaucophyllum

Summary

Summary: A plant species of the genus SOLANUM, family SOLANACEAE that causes CALCINOSIS in grazing livestock due to high levels of 1a,25-dihydroxy vitamin D3 (CALCITRIOL).

Top Publications

  1. Gil S, Dallorso M, Horst R. Screening of Vitamin D activity (VDA) of Solanum glaucophyllum leaves measured by radioimmunoassay (RIA). J Steroid Biochem Mol Biol. 2007;103:483-6 pubmed
    The ingestion of Solanum glaucophyllum (SG) causes a calcinosis of cattle named Enteque Seco (ES). The toxic principle is the 1,25-(OH)(2)D(3), mainly conjugated as glycoside...
  2. Zanuzzi C, Fontana P, Barbeito C, Portiansky E, Gimeno E. Paneth cells: histochemical and morphometric study in control and Solanum glaucophyllum intoxicated rabbits. Eur J Histochem. 2008;52:93-100 pubmed
    ..b>Solanum glaucophyllum, a calcinogenic plant containing high levels of 1,25-dihydroxyvitamin D3, is responsible for a condition ..
  3. Zanuzzi C, Barbeito C, Ortiz M, Lozza F, Fontana P, Portiansky E, et al. Glycoconjugate histochemistry in the small and large intestine of normal and Solanum glaucophyllum-intoxicated rabbits. Res Vet Sci. 2010;89:214-22 pubmed publisher
    ..The leaves of Solanum glaucophyllum contain high levels of 1,25-dihydroxyvitamin D3 as glycoside derivatives and their chronic ingestion ..
  4. Jäpelt R, Silvestro D, Smedsgaard J, Jensen P, Jakobsen J. Quantification of vitamin D3 and its hydroxylated metabolites in waxy leaf nightshade (Solanum glaucophyllum Desf.), tomato (Solanum lycopersicum L.) and bell pepper (Capsicum annuum L.). Food Chem. 2013;138:1206-11 pubmed publisher
    ..in vitamin D(3) and its metabolites were investigated following UVB- and heat-treatment in the leaves of Solanum glaucophyllum Desf., Solanum lycopersicum L. and Capsicum annuum L...
  5. Mathis G, Boland R, Bachmann H, Toggenburger A, Rambeck W. Safety profile of 1,25-dihydroxyvitamin D3 of herbal origin in broiler chicken. Schweiz Arch Tierheilkd. 2016;158:819-826 pubmed
    The safety of supplementing broiler feed with a standardised herbal extract, Solanum Glaucophyllum Standardised Leaves (SGSL) containing glycosylated 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) and standardised to contain 10 µg/g 1,25(OH)..
  6. Bachmann H, Lanz M, Kehrle S, Bittner W, Toggenburger A, Mathis G, et al. Effects of a sustained release formulation of 1,25-dihydroxyvitamin D3-glycosides for milk fever prevention on serum 1,25-dihydroxyvitamin D3, calcium and phosphorus in dairy cows. J Steroid Biochem Mol Biol. 2017;173:301-307 pubmed publisher
    ..after stopping the treatment with 1,25(OH)2D3, a new approach was chosen by applying Solanum glaucophyllum extract (SGE), which contains 1,25(OH)2D3-glycosides, as instant-release (irSGE) in ..
  7. Ishii J, Uramoto A, Nagao Y, Goto H. Feeding Solanum glaucophyllum to preparturient multiparous cows prevents postparturient hypocalcemia. Anim Sci J. 2015;86:869-77 pubmed publisher
    b>Solanum glaucophyllum (SG) contains 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) glycosides. We investigated the effect of SG on hypocalcemia in cows...
  8. Schlegel P, Guggisberg D, Gutzwiller A. Tolerance to 1,25 dihydroxyvitamin D3 glycosides from Solanum glaucophyllum by the growing pig. Res Vet Sci. 2017;112:119-124 pubmed publisher
    b>Solanum glaucophyllum leaves contain high levels of glycosidically bound 1,25 dihydroxyvitamin D3, the most important vitamin D metabolite...
  9. Odriozola E, Rodríguez A, Micheloud J, Cantón G, Caffarena R, Gimeno E, et al. Enzootic calcinosis in horses grazing Solanum glaucophyllum in Argentina. J Vet Diagn Invest. 2018;30:286-289 pubmed publisher
    b>Solanum glaucophyllum, a toxic plant known for its calcinogenic effects, causes enzootic calcinosis in ruminant and monogastric animals...

More Information

Publications15

  1. Gili V, Pardo V, Ronda A, De Genaro P, Bachmann H, Boland R, et al. In vitro effects of 1α,25(OH)₂D₃-glycosides from Solbone A (Solanum glaucophyllum leaves extract; Herbonis AG) compared to synthetic 1α,25(OH)₂D₃ on myogenesis. Steroids. 2016;109:7-15 pubmed publisher
    ..In this work, we evaluated the role 1α,25(OH)2D3-glycosides enriched natural product (Solbone A) from Solanum glaucophyllum leaf extract compared with synthetic 1α,25(OH)2D3 on myogenic differentiation in C2C12 myoblasts...
  2. Cheng Y, Goff J, Sell J, Dallorso M, Gil S, Pawlak S, et al. Utilizing Solanum glaucophyllum alone or with phytase to improve phosphorus utilization in broilers. Poult Sci. 2004;83:406-13 pubmed
    Experiments were conducted to determine if Solanum glaucophyllum (SG), a plant containing a glycoside of 1,25-dihydroxyvitamin D, could be used as a feed additive to improve P utilization of broilers. SG leaves (1, 2...
  3. Barros S, Soares M, Gimeno E. Macrophages and giant cell proliferation associated with bone protein synthesis and calcification in the trachea and bronchi of rabbits intoxicated with Solanum glaucophyllum. Vet Pathol. 2006;43:494-9 pubmed
    ..study of the trachea and the bronchi of 6 rabbits experimentally intoxicated with the calcinogenic plant Solanum glaucophyllum was performed...
  4. Zanuzzi C, Nishida F, Portiansky E, Fontana P, Gimeno E, Barbeito C. Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits. Res Vet Sci. 2012;93:336-42 pubmed publisher
    ..epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant Solanum glaucophyllum. Rabbits were treated for 15 or 30 days...
  5. Bachmann H, Offord Cavin E, Phothirath P, Horcajada M, Romeis P, Mathis G. 1,25-Dihydroxyvitamin D3-glycoside of herbal origin exhibits delayed release pharmacokinetics when compared to its synthetic counterpart. J Steroid Biochem Mol Biol. 2013;136:333-6 pubmed publisher
    ..A natural form of the active metabolite was identified in a few plants, such as Solanum glaucophyllum (SG) and suggested as alternative for animal and human health...
  6. Bachmann H, Autzen S, Frey U, Wehr U, Rambeck W, McCormack H, et al. The efficacy of a standardised product from dried leaves of Solanum glaucophyllum as source of 1,25-dihydroxycholecalciferol for poultry. Br Poult Sci. 2013;54:642-52 pubmed publisher
    1. Chemical characterisation of an extract of Solanum glaucophyllum (SG) leaves affirmed the predominant presence of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) glycosides...