lycium

Summary

Summary: A plant genus of the family SOLANACEAE. Members contain CEREBROSIDES and SCOPOLETIN.

Top Publications

  1. Gan L, Hua Zhang S, Liang Yang X, Bi Xu H. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int Immunopharmacol. 2004;4:563-9 pubmed
    The modulation of a polysaccharide-protein complex from Lycium barbarum (LBP3p) on the immune system in S180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o...
  2. Zhi F, Zheng W, Chen P, He M. [Study on the extraction process of polysaccharide from Lycium barbarum]. Zhong Yao Cai. 2004;27:948-50 pubmed
    To choose the optimum extration process of polysaccharide from Lycium barbarum L.
  3. Adams M, Wiedenmann M, Tittel G, Bauer R. HPLC-MS trace analysis of atropine in Lycium barbarum berries. Phytochem Anal. 2006;17:279-83 pubmed
    The dried ripe fruits of Barbary wolfberry, Lycium barbarum L. are widely used in China for medicinal purposes and as a functional food. Previous investigations reported to have found atropine in Barbary wolfberries from India...
  4. Liu H, Fan Y, Wang W, Liu N, Zhang H, Zhu Z, et al. Polysaccharides from Lycium barbarum leaves: isolation, characterization and splenocyte proliferation activity. Int J Biol Macromol. 2012;51:417-22 pubmed publisher
    The polysaccharides from the fruits of Lycium barbarum have received considerable attention in previous publication, but the polysaccharides from the leaves were rarely reported...
  5. Rivera C, Ferro C, Bursua A, Gerber B. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy. 2012;32:e50-3 pubmed publisher
    b>Lycium barbarum (also called goji berry), a Chinese herb used as a supplement for health benefits, is traditionally consumed by the Chinese in the form of a tea...
  6. Yi R, Liu X, Dong Q. A study of Lycium barbarum polysaccharides (LBP) extraction technology and its anti-aging effect. Afr J Tradit Complement Altern Med. 2013;10:171-4 pubmed
    ..We concluded that the extraction method established in this experiment is easy and feasible, and the yield of LBP is high, apparently showing that LBP has the potential of delaying senility in D-gal induced mice. ..
  7. Teng P, Li Y, Cheng W, Zhou L, Shen Y, Wang Y. Neuroprotective effects of Lycium barbarum polysaccharides in lipopolysaccharide-induced BV2 microglial cells. Mol Med Rep. 2013;7:1977-81 pubmed publisher
    Polysaccharides extracted from Lycium barbarum (LBPs) possess a wide variety of biological activities. However, their neuroprotective effects have not yet been fully elucidated...
  8. Cheng D, Kong H. The effect of Lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats. Molecules. 2011;16:2542-50 pubmed publisher
    The aim of this study was to investigate the effects of Lycium barbarum polysaccharide (LBP) on alcohol-induced liver damage in rats. A total of 36 rats were divided into control, ethanol and ethanol + LBP groups...
  9. Luo Q, Cui X, Yan J, Yang M, Liu J, Jiang Y, et al. Antagonistic effects of Lycium barbarum polysaccharides on the impaired reproductive system of male rats induced by local subchronic exposure to 60Co-? irradiation. Phytother Res. 2011;25:694-701 pubmed publisher
    b>Lycium barbarum, a famous Chinese medicinal herb, has a long history of use in traditional medicine as an antioxidant and to promote sexual fertility. Polysaccharides are the most important functional constituents in L. barbarum fruits...

More Information

Publications84

  1. Inbaraj B, Lu H, Kao T, Chen B. Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC-DAD-ESI-MS. J Pharm Biomed Anal. 2010;51:549-56 pubmed publisher
    ..mode (HPLC-DAD-ESI-MS) was developed for simultaneous determination of phenolic acids and flavonoids in fruits of Lycium barbarum Linnaeus, a widely used traditional Chinese herb possessing vital biological activity...
  2. Zhang X, Zhou W, Zhang Y, Qi C, Yan H, Wang Z, et al. Macrophages, rather than T and B cells are principal immunostimulatory target cells of Lycium barbarum L. polysaccharide LBPF4-OL. J Ethnopharmacol. 2011;136:465-72 pubmed publisher
    b>Lycium barbarum L. is a renowned Yin strengthening agent in traditional Chinese medicine. Lycium barbarum L. polysaccharide-protein complex is well-known for its immunoregulatory and antitumor effects...
  3. Chen Z, Soo M, Srinivasan N, Tan B, Chan S. Activation of macrophages by polysaccharide-protein complex from Lycium barbarum L. Phytother Res. 2009;23:1116-22 pubmed publisher
    ..This paper reports that a polysaccharide-protein complex isolated from Lycium barbarum (LBP) is able to activate macrophages...
  4. Leung H, Hung A, Hui A, Chan T. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol. 2008;46:1860-2 pubmed publisher
    ..experienced two episodes of an elevated international normalized ratio (INR) after drinking herbal tea containing Lycium barbarum L. Our case illustrated the potential herbal-drug interaction between warfarin and L. barbarum L...
  5. Yamada P, Nemoto M, Shigemori H, Yokota S, Isoda H. Isolation of 5-(hydroxymethyl)furfural from Lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells. Planta Med. 2011;77:434-40 pubmed publisher
    The effect of hot water extracts of LYCIUM CHINENSE fruits (LCF) on the ?-hexosaminidase (?-hexo) release by IgE sensitized BSA stimulated rat basophilic leukemia (RBL-2H3) cells was investigated...
  6. Yu M, Lai C, Ho Y, Zee S, So K, Yuen W, et al. Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. Int J Mol Med. 2007;20:261-8 pubmed
    ..Fructus lycii (the fruit of Lycium barbarum) has long been used in oriental medicine as an anti-aging agent...
  7. Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76:7-19 pubmed publisher
    ..Goji is a relatively new name given to Lycium barbarum and L...
  8. Li X, Ma Y, Liu X. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol. 2007;111:504-11 pubmed
    ..Consequently, the concept of anti-age by antioxidants has been developed. Lycium barbarum fruits have been used as a traditional Chinese herbal medicine and the data obtained in in vitro models ..
  9. Zhang R, Kang K, Piao M, Kim K, Kim A, Chae S, et al. Cytoprotective effect of the fruits of Lycium chinense Miller against oxidative stress-induced hepatotoxicity. J Ethnopharmacol. 2010;130:299-306 pubmed publisher
    Fruits of Lycium chinense Miller (Solanaceae), distributed in northeast Asia, have gained attraction for their hepatoprotective role in traditional oriental medicine...
  10. Chan J, Leung P, Che C, Fung K. Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: an implication for its treatment of diabetes mellitus. Phytother Res. 2008;22:190-6 pubmed
    ..The implication of SR10 in treating type 2 diabetes mellitus was discussed...
  11. Zhang H, Tang M, Chen H, Wang Y. Effects of a dark-septate endophytic isolate LBF-2 on the medicinal plant Lycium barbarum L. J Microbiol. 2012;50:91-6 pubmed publisher
    ..Here, we investigated the positive effect of a DSE fungus on its host plant Lycium barbarum L. A DSE isolate, LBF-2, isolated from the roots of L...
  12. Ho Y, Yu M, Lai C, So K, Yuen W, Chang R. Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity. Brain Res. 2007;1158:123-34 pubmed
    b>Lycium barbarum is an oriental medicinal herb that has long been used for its anti-aging and cell-protective properties. Previous studies have shown that aqueous extracts from L...
  13. Chiu K, Zhou Y, Yeung S, Lok C, Chan O, Chang R, et al. Up-regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model. J Cell Biochem. 2010;110:311-20 pubmed publisher
    Wolfberry (fruit of Lycium barbarum Linn) has been known for balancing 'Yin' and 'Yang' in the body, nourishing the liver and kidney, improving visual acuity for more than 2,500 years in oriental countries...
  14. Zhu J, Liu W, Yu J, Zou S, Wang J, Yao W, et al. Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. Carbohydr Polym. 2013;98:8-16 pubmed publisher
    ..In this study, a novel acidic polysaccharide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macroporous resin and ion-exchanged column...
  15. Zhang Y, Wang J, Liu L, Chang R, So K, Ju G. The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats. BMC Complement Altern Med. 2013;13:67 pubmed publisher
    ..This explained the difference between the pre- and post-treated groups. Lycium barbarum has been wildly accepted to have beneficial effects in various central nervous system diseases...
  16. Wu S, Ng L, Lin C. Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos. Phytother Res. 2004;18:1008-12 pubmed
    ..activities of three popular ingredients of traditional Chinese medicine, namely Angelica sinensis (AS), Lycium barbarum (LB) and Poria cocos (PC) were evaluated in this study...
  17. Duan H, Chen Y, Chen G. Far infrared-assisted extraction followed by capillary electrophoresis for the determination of bioactive constituents in the leaves of Lycium barbarum Linn. J Chromatogr A. 2010;1217:4511-6 pubmed
    ..extraction has been developed for the determination of rutin, gentisic acid, and quercetin in the leaves of Lycium barbarum Linn...
  18. Tang T, He B. Treatment of d-galactose induced mouse aging with Lycium barbarum polysaccharides and its mechanism study. Afr J Tradit Complement Altern Med. 2013;10:12-7 pubmed
    We evaluated the effects of Lycium barbarum polysaccharides LBP) on D-galactose aging model mouse, and explored its possible mechanism...
  19. Miranda M, Arnal E, Ahuja S, Alvarez Nölting R, López Pedrajas R, Ekstrom P, et al. Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism. Free Radic Biol Med. 2010;48:216-22 pubmed publisher
    ..to understand the mechanism of action of these substances (zeaxanthin, lutein, alpha-lipoic acid, glutathione, and Lycium barbarum extract) the changes in the levels of several proteins and oxidative stress markers in the rd1 retina ..
  20. Ho Y, Yu M, Yik S, So K, Yuen W, Chang R. Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cell Mol Neurobiol. 2009;29:1233-44 pubmed publisher
    ..Attenuation of glutamate toxicity is one of the therapeutic strategies for AD. Wolfberry (Lycium barbarum) is a common ingredient in oriental cuisines...
  21. Wu P, Wu S, Tsai Y, Lin Y, Chao J. Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats. Am J Chin Med. 2011;39:1173-91 pubmed
    Polysaccharide-rich Lycium barbarum and Rehmannia glutinosa have been considered to have immune-modulating activity...
  22. Xiao J, Liong E, Ching Y, Chang R, So K, Fung M, et al. Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J Ethnopharmacol. 2012;139:462-70 pubmed publisher
    b>Lycium barbarum has been used as a traditional Chinese medicine to nourish liver, kidneys and the eyes.
  23. Yeung K, Miller J, Savage A, Husband B, Igic B, Kohn J. Association of ploidy and sexual system in Lycium californicum (Solanaceae). Evolution. 2005;59:2048-55 pubmed
    In North American Lycium (Solanaceae), the evolution of gender dimorphism has been proposed as a means of restoring outcrossing after polyploidization causes the loss of self-incompatibility...
  24. Gan L, Zhang S, Liu Q, Xu H. A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells. Eur J Pharmacol. 2003;471:217-22 pubmed
    ..In this study, the effects of Lycium barbarum polysaccharide-protein complex (LBP(3p)) on the expression of interleukin-2 and tumor necrosis factor-..
  25. Levin R, Whelan A, Miller J. The utility of nuclear conserved ortholog set II (COSII) genomic regions for species-level phylogenetic inference in Lycium (Solanaceae). Mol Phylogenet Evol. 2009;53:881-90 pubmed publisher
  26. Huang X, Yang M, Wu X, Yan J. [Study on protective action of lycium barbarum polysaccharides on DNA imparments of testicle cells in mice]. Wei Sheng Yan Jiu. 2003;32:599-601 pubmed
    To investigate the protective effect of lycium barbarum polysaccharides (LBP) on DNA oxidative damage of testicle cells induced by hydrogen peroxide (H2O2)...
  27. Luo Q, Cai Y, Yan J, Sun M, Corke H. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 2004;76:137-49 pubmed
    The hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were ..
  28. Yang D, Li S, Yeung C, Chang R, So K, Wong D, et al. Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke. PLoS ONE. 2012;7:e33596 pubmed publisher
    ..The extracts from the fruits of Lycium barbarum (LBP), a Chinese anti-aging medicine and food supplement, showed neuroprotective function in the retina ..
  29. Savage A, Miller J. Gametophytic self-incompatibility in Lycium parishii (Solanaceae): allelic diversity, genealogical structure, and patterns of molecular evolution at the S-RNase locus. Heredity (Edinb). 2006;96:434-44 pubmed
    We characterized allelic diversity at the locus controlling self-incompatibility (SI) for a population of Lycium parishii (Solanaceae) from Organ Pipe National Monument, Arizona...
  30. Zhao H, Alexeev A, Chang E, Greenburg G, Bojanowski K. Lycium barbarum glycoconjugates: effect on human skin and cultured dermal fibroblasts. Phytomedicine. 2005;12:131-7 pubmed
    b>Lycium barbarum L. (Solanaceae) glycoconjugates (LbGp) display an interesting array of anti-apoptotic and antioxidant properties, which may be beneficial for human skin...
  31. Zhang M, Chen H, Huang J, Li Z, Zhu C, Zhang S. Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 2005;76:2115-24 pubmed
    b>Lycium barbarum polysaccharide (LBP), extracted from Lycium barbarum that is a kind of traditional Chinese herb, is found to have anticancer activity...
  32. Deng H, Cui D, Jiang J, Feng Y, Cai N, Li D. Inhibiting effects of Achyranthes bidentata polysaccharide and Lycium barbarum polysaccharide on nonenzyme glycation in D-galactose induced mouse aging model. Biomed Environ Sci. 2003;16:267-75 pubmed
    To investigate the inhibiting effects and mechanism of achyranthes bidentata polysaccharide (ABP) and lycium barbarum polysaccharide (LBP) on nonenzyme glycation in D-galactose induced mouse aging model.
  33. Xin Y, Wan L, Peng J, Guo C. Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress. Food Chem Toxicol. 2011;49:259-64 pubmed publisher
    The present study aims to investigate whether Lycium barbarum polysaccharides (LBP) could protect against acute doxorubicin (DOX)-induced cardiotoxicity...
  34. Zhang J, Guan S, Feng R, Wang Y, Wu Z, Zhang Y, et al. Neolignanamides, lignanamides, and other phenolic compounds from the root bark of Lycium chinense. J Nat Prod. 2013;76:51-8 pubmed publisher
    ..and a new lignanamide (8) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root bark of Lycium chinense, together with 22 known phenolic compounds (9-30), four of which were obtained from the genus Lycium for ..
  35. Zheng R, Sijun Yue -, Xu X, Liu J, Xu Q, Wang X, et al. Proteome analysis of the wild and YX-1 male sterile mutant anthers of wolfberry (Lycium barbarum L.). PLoS ONE. 2012;7:e41861 pubmed publisher
    Pollen development is disturbed in the early tetrad stage of the YX-1 male sterile mutant of wolfberry (Lycium barbarum L.)...
  36. Jing L, Cui G, Feng Q, Xiao Y. Evaluation of hypoglycemic activity of the polysaccharides extracted from Lycium barbarum. Afr J Tradit Complement Altern Med. 2009;6:579-84 pubmed
    A study was undertaken to evaluate the hypoglycemic activity of polysaccharide extracted from Lycium barbarum (LBP)...
  37. Luo Q, Li Z, Yan J, Zhu F, Xu R, Cai Y. Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. J Med Food. 2009;12:695-703 pubmed publisher
    b>Lycium barbarum polysaccharides (LBPs) are important functional constituents in red-colored fruits of L. barbarum (Guo Qi Zi, a well-known traditional Chinese medicinal plant commonly known as Goji berry or wolfberry)...
  38. Niu A, Wu J, Yu D, Wang R. Protective effect of Lycium barbarum polysaccharides on oxidative damage in skeletal muscle of exhaustive exercise rats. Int J Biol Macromol. 2008;42:447-9 pubmed publisher
    The aim of this study was to determine the modulatory effect of Lycium barbarum polysaccharides (LBP) on the oxidative stress induced by an exhaustive exercise. 32 male Wistar rats were taken in the study...
  39. Hai Yang G, Ping S, Li J, Chang Hong X, Fu T. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. J Exp Ther Oncol. 2004;4:181-7 pubmed
    To investigate the therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice.
  40. Ha K, Yoon S, Choi D, Kim D, Kim J, Kim C. Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. J Ethnopharmacol. 2005;96:529-35 pubmed
    In the present study, we investigated the protective effect of Lycium chinense Miller (Solanaceae) fruit (LFE) against CCl(4)-induced hepatotoxicity and the mechanism underlying these protective effects in rats...
  41. Gan L, Wang J, Zhang S. [Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide]. Wei Sheng Yan Jiu. 2001;30:333-5 pubmed
    The effect and the mechanism of Lycium barbarum polysaccharide (LBP-X) on inhibiting the growth of human leukemia HL-60 cells were examined...
  42. Lin N, Lin J, Chen S, Ho C, Yeh A. Effect of Goji (Lycium barbarum) on expression of genes related to cell survival. J Agric Food Chem. 2011;59:10088-96 pubmed publisher
    This study investigated the interrelationship between Lycium barbarum (goji) and gene expression in mouse spleen...
  43. Amagase H, Nance D. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. J Am Coll Nutr. 2011;30:304-9 pubmed
    b>Lycium barbarum (L...
  44. Paul Hsu C, Nance D, Amagase H. A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum. J Med Food. 2012;15:1006-14 pubmed publisher
    ..blind, placebo-controlled clinical trials were pooled to study the general effects of oral consumption of Lycium barbarum at 120?mL/day, as a standardized juice, GoChi(®) (FreeLife International, Phoenix, AZ, USA)...
  45. Tang W, Chan E, Kwok C, Lee Y, Wu J, Wan C, et al. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology. 2012;20:307-14 pubmed publisher
    ..b>Lycium barbarum fruit, commonly known as Gou Qi Zi in China, is a potential anticancer agent/adjuvant...
  46. Miao Y, Xiao B, Jiang Z, Guo Y, Mao F, Zhao J, et al. Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide. Med Oncol. 2010;27:785-90 pubmed publisher
    b>Lycium barbarum polysaccharide (LBP) is extracted from the traditional Chinese herb Lycium barbarum, and has potential anticancer activity. However, the detailed mechanisms are largely unknown...
  47. Du G, Liu L, Fang J. Experimental study on the enhancement of murine splenic lymphocyte proliferation by Lycium barbarum glycopeptide. J Huazhong Univ Sci Technolog Med Sci. 2004;24:518-20, 527 pubmed
    In order to investigate the immunoactivity of Lycium Barbarum glycopeptide (LBG), the routinely prepared murine splenic lymphocyte suspension was separately added into the samples with different concentrations (500, 100, 10, 1 microg/ml) ..
  48. Luo Q, Li Z, Huang X, Yan J, Zhang S, Cai Y. Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sci. 2006;79:613-21 pubmed
    b>Lycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits...
  49. Chen Z, Lu J, Srinivasan N, Tan B, Chan S. Polysaccharide-protein complex from Lycium barbarum L. is a novel stimulus of dendritic cell immunogenicity. J Immunol. 2009;182:3503-9 pubmed publisher
    ..In this study, we report that a nontoxic polysaccharide-protein complex isolated from a Chinese medicinal herb, Lycium barbarum (LBP), induces phenotypic and functional maturation of DCs with strong immunogenicity...
  50. Peng Y, Ma C, Li Y, Leung K, Jiang Z, Zhao Z. Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii). Plant Foods Hum Nutr. 2005;60:161-4 pubmed
    ..for the content of zeaxanthin dipalmitate, a major carotenoid in Fructus Lycii, in different species of the genus Lycium. Determination was performed using an Alltima C18 column with the mobile phase consisting of acetonitrile and ..
  51. Amagase H, Sun B, Nance D. Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects. J Med Food. 2009;12:1159-65 pubmed publisher
    b>Lycium barbarum has been traditionally used in combination with several herbs for medicinal properties, but systematic modern clinical evaluation as a single herb has not been reported. To examine the systematic effects of L...
  52. Inbaraj B, Lu H, Hung C, Wu W, Lin C, Chen B. Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC-DAD-APCI-MS. J Pharm Biomed Anal. 2008;47:812-8 pubmed publisher
    The fruit of Lycium barbarum Linnaeus, a traditional Chinese herb containing functional components such as carotenoids, flavonoids and polysaccharides, has been widely used in the health food industry because of its possible role in the ..
  53. Xin Y, Zhou G, Deng Z, Chen Y, Wu Y, Xu P, et al. Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity. Phytother Res. 2007;21:1020-4 pubmed
    The objective of this work was to explore the hypothesis that Lycium barbarum (LB) may be protective against doxorubicin (DOX)-induced cardiotoxicity through antioxidant-mediated mechanisms...
  54. Chao J, Chiang S, Wang C, Tsai Y, Wu M. Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells. World J Gastroenterol. 2006;12:4478-84 pubmed
    To investigate the effect of hot water-extracted Lycium barbarum (LBE) and Rehmannia glutinosa (RGE) on cell proliferation and apoptosis in rat and/or human hepatocellular carcinoma (HCC) cells.
  55. Li H, Liang Y, Chiu K, Yuan Q, Lin B, Chang R, et al. Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection. PLoS ONE. 2013;8:e68881 pubmed publisher
    Our group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models...
  56. Yin X, Fang K, Liang Y, Wong R, Ha A. Assessing phylogenetic relationships of Lycium samples using RAPD and entropy theory. Acta Pharmacol Sin. 2005;26:1217-24 pubmed
    To evaluate the phylogenetic relationships among related species of Lycium samples.
  57. Dong J, Wang Y, Wang S, Yin L, Xu G, Zheng C, et al. Selenium increases chlorogenic acid, chlorophyll and carotenoids of Lycium chinense leaves. J Sci Food Agric. 2013;93:310-5 pubmed publisher
    Leaves of Lycium chinense L. are widely used in traditional Chinese medicine and as functional food in China and south-east Asia. Polyphenols are important active compounds in leaves of L...
  58. Song M, Salam N, Roufogalis B, Huang T. Lycium barbarum (Goji Berry) extracts and its taurine component inhibit PPAR-?-dependent gene transcription in human retinal pigment epithelial cells: Possible implications for diabetic retinopathy treatment. Biochem Pharmacol. 2011;82:1209-18 pubmed publisher
    ..Taurine is abundant in the fruit of Lycium barbarum (Goji Berry), and is reportedly beneficial for diabetic retinopathy...
  59. Li S, Yang D, Yeung C, Yu W, Chang R, So K, et al. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS ONE. 2011;6:e16380 pubmed publisher
    ..b>Lycium barbarum polysaccharides (LBP), extracts from the wolfberries, are good for "eye health" according to ..
  60. Miller J, Levin R, Feliciano N. A tale of two continents: Baker's rule and the maintenance of self-incompatibility in Lycium (Solanaceae). Evolution. 2008;62:1052-65 pubmed publisher
    ..The genus Lycium (Solanaceae) has ca...
  61. Lee D, Park Y, Kim M, Jung H, Seu Y, Hahm K, et al. Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense. Biotechnol Lett. 2004;26:1125-30 pubmed
    ..3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller...
  62. Oh Y, Cho W, Im G, Jeong Y, Hwang Y, Liang C, et al. Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. Int Immunopharmacol. 2012;13:181-9 pubmed publisher
    b>Lycium Fruit has been used as a traditional drug for low back pain and chronic cough in east-Asian countries. However, inhibitory effects of Lycium Fruit water extract (LFWE) on inflammation remain unknown...
  63. Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res. 2009;29:19-25 pubmed publisher
    Although Lycium barbarum (goji) and active compounds, Lycium barbarum polysaccharides (LBP), have a high in vitro antioxidant score as determined by simple chemical reaction methods, their in vivo antioxidant effects in humans have not ..
  64. Jin M, Huang Q, Zhao K, Shang P. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L. Int J Biol Macromol. 2013;54:16-23 pubmed publisher
    ..The fruit of Lycium barbarum L...
  65. Amagase H, Nance D. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi. J Altern Complement Med. 2008;14:403-12 pubmed publisher
    ..the first study reported from outside China that has examined the general effects of the orally consumed goji berry, Lycium barbarum, as a standardized juice (GoChi; FreeLife International LLC, Phoenix, AZ) to healthy adults for 14 days.
  66. Miller J, Venable D. Floral morphometrics and the evolution of sexual dimorphism in Lycium (Solanaceae). Evolution. 2003;57:74-86 pubmed
    Plants of Lycium californicum, L. exsertum, and L. fremontii produce flowers that are either male-sterile (female) or hermaphroditic, and populations are morphologically gynodioecious...
  67. Zhu J, Zhang Y, Shen Y, Zhou H, Yu X. Lycium barbarum polysaccharides induce Toll-like receptor 2- and 4-mediated phenotypic and functional maturation of murine dendritic cells via activation of NF-?B. Mol Med Rep. 2013;8:1216-20 pubmed publisher
    ..b>Lycium barbarum polysaccharides (LBPs) are known to have a variety of immunomodulatory functions...
  68. Dong J, Lu D, Wang Y. Analysis of flavonoids from leaves of cultivated Lycium barbarum L. Plant Foods Hum Nutr. 2009;64:199-204 pubmed publisher
    Leaves of Lycium barbarum are widely used as medicine vegetables and functional tea in China...
  69. Lin F, Chiu C, Pan T. Fermentation of a milk-soymilk and Lycium chinense Miller mixture using a new isolate of Lactobacillus paracasei subsp. paracasei NTU101 and Bifidobacterium longum. J Ind Microbiol Biotechnol. 2004;31:559-64 pubmed
    ..The milk-soymilk mixture was supplemented with 5, 10, 15, and 20% Lycium chinense Miller juice and fermented with Lactobacillus paracasei subsp. paracasei NTU101 and B. longum BCRC11847...
  70. Yu M, Leung S, Lai S, Che C, Zee S, So K, et al. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity. Exp Gerontol. 2005;40:716-27 pubmed
    ..Natural plant extracts of Lycium barbarum are well-known to exhibit anti-aging effects...
  71. Lin C, Wang C, Chang S, Inbaraj B, Chen B. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int J Biol Macromol. 2009;45:146-51 pubmed publisher
    Antioxidant activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus was evaluated...
  72. Li G, Sepkovic D, Bradlow H, Telang N, Wong G. Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism. Nutr Cancer. 2009;61:408-14 pubmed publisher
    ..The ER+ MCF-7 model examined growth inhibitory effects of the medicinal herb Lycium barbarum (LB) and identified mechanistic leads for its efficacy. The MCF-7 cells maintained in 0...
  73. Cui B, Liu S, Lin X, Wang J, Li S, Wang Q, et al. Effects of Lycium barbarum aqueous and ethanol extracts on high-fat-diet induced oxidative stress in rat liver tissue. Molecules. 2011;16:9116-28 pubmed publisher
    This study evaluated the protective effects of aqueous extract of Lycium barbarum (LBAE) and ethanol extract of Lycium barbarum (LBEE) on blood lipid levels, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline ..
  74. Chan J, Lam F, Leung P, Che C, Fung K. Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Phytother Res. 2009;23:658-65 pubmed publisher
    ..The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up-regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host...
  75. Wang Y, Zhao H, Sheng X, Gambino P, Costello B, Bojanowski K. Protective effect of Fructus Lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J Ethnopharmacol. 2002;82:169-75 pubmed
    b>Lycium barbarum L. (Solanaceae) is a Chinese medicinal plant whose fruits (Fructus Lycii) are used by Chinese physicians for treatment of infertility...