hyoscyamus

Summary

Summary: A plant genus of the family SOLANACEAE which contains TROPANES.

Top Publications

  1. Mohammad M, Almasri I, Tawaha K, Issa A, Al Nadaf A, Hudaib M, et al. Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities of Hyoscyamus reticulatus. Pharm Biol. 2010;48:1376-83 pubmed publisher
    ..It catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid, the reaction involves the formation of free radical intermediates and superoxide byproducts...
  2. Jiang K, Pi Y, Hou R, Jiang L, Sun X, Tang K. Promotion of nicotine biosynthesis in transgenic tobacco by overexpressing allene oxide cyclase from Hyoscyamus niger. Planta. 2009;229:1057-63 pubmed publisher
    ..3.99.6) catalyzes the most crucial step. Here a heterologous AOC gene from Hyoscyamus niger L. (black henbane), named HnAOC (GenBank accession No...
  3. Weber J, Georgiev V, Pavlov A, Bley T. Flow cytometric investigations of diploid and tetraploid plants and in vitro cultures of Datura stramonium and Hyoscyamus niger. Cytometry A. 2008;73:931-9 pubmed publisher
    ..Diploid and tetraploid Datura stramonium and Hyoscyamus niger plant as well as calli, and hairy root lines derived from them were analyzed by flow cytometry...
  4. Higa A, Miyamoto E, ur Rahman L, Kitamura Y. Root tip-dependent, active riboflavin secretion by Hyoscyamus albus hairy roots under iron deficiency. Plant Physiol Biochem. 2008;46:452-60 pubmed publisher
    b>Hyoscyamus albus hairy roots with/without an exogenous gene (11 clones) were established by inoculation of Agrobacterium rhizogenes...
  5. Wilhelmson A, Häkkinen S, Kallio P, Oksman Caldentey K, Nuutila A. Heterologous expression of Vitreoscilla hemoglobin (VHb) and cultivation conditions affect the alkaloid profile of Hyoscyamus muticus hairy roots. Biotechnol Prog. 2006;22:350-8 pubmed
    Fast-growing hairy root cultures of Hyoscyamus muticus induced by Agrobacterium rhizogenes offer a potential production system for tropane alkaloids...
  6. Zhang L, Ding R, Chai Y, Bonfill M, Moyano E, Oksman Caldentey K, et al. Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures. Proc Natl Acad Sci U S A. 2004;101:6786-91 pubmed
    ..the downstream enzyme hyoscyamine 6 beta-hydroxylase (H6H) of scopolamine biosynthesis in transgenic henbane (Hyoscyamus niger) hairy root cultures...
  7. Wilhelmson A, Kallio P, Oksman Caldentey K, Nuutila A. Expression of Vitreoscilla hemoglobin enhances growth of Hyoscyamus muticus hairy root cultures. Planta Med. 2005;71:48-53 pubmed
    The Vitreoscilla hemoglobin gene (vhb) was introduced into Hyoscyamus muticus with the aim of investigating its effect on growth and alkaloid production of Agrobacterium rhizogenes-induced hairy root cultures...
  8. Khan A, Gilani A. Cardiovascular inhibitory effects of Hyoscyamus niger. Methods Find Exp Clin Pharmacol. 2008;30:295-300 pubmed publisher
    This study describes the hypotensive, cardiosuppressant and vasodilator activities of Hyoscyamus niger crude extract (Hn.Cr). Hn...
  9. Gilani A, Khan A, Raoof M, Ghayur M, Siddiqui B, Vohra W, et al. Gastrointestinal, selective airways and urinary bladder relaxant effects of Hyoscyamus niger are mediated through dual blockade of muscarinic receptors and Ca2+ channels. Fundam Clin Pharmacol. 2008;22:87-99 pubmed publisher
    ..the spasmolytic, antidiarrhoeal, antisecretory, bronchodilatory and urinary bladder relaxant properties of Hyoscyamus niger to rationalize some of its medicinal uses. The crude extract of H. niger seeds (Hn...

More Information

Publications53

  1. Zhang L, Yang B, Lu B, Kai G, Wang Z, Xia Y, et al. Tropane alkaloids production in transgenic Hyoscyamus niger hairy root cultures over-expressing putrescine N-methyltransferase is methyl jasmonate-dependent. Planta. 2007;225:887-96 pubmed
    ..step in the biosynthesis of tropane alkaloids, has been introduced into the genome of a scopolamine-producing Hyoscyamus niger mediated by the disarmed Agrobacterium tumefaciens strain C58C1, which also carries Agrobacterium ..
  2. Kerchner A, Darók J, Bacskay I, Felinger A, Jakab G, Farkas Ã. Protein and alkaloid patterns of the floral nectar in some solanaceous species. Acta Biol Hung. 2015;66:304-15 pubmed publisher
    ..tabacum having the highest nicotine content. The nectar of Brugmansia suaveolens, Datura stramonium, Hyoscyamus niger and Lycium barbarum contained scopolamine, the highest content of which was measured in B. suaveolens...
  3. Geng C, Zhao T, Yang C, Zhang Q, Bai F, Zeng J, et al. Metabolic characterization of Hyoscyamus niger root-specific putrescine N-methyltransferase. Plant Physiol Biochem. 2018;127:47-54 pubmed publisher
    ..We characterized a PMT gene from Hyoscyamus niger, designated HnPMT that was specifically expressed in roots, especially in the secondary roots and ..
  4. Xia K, Liu X, Zhang Q, Qiang W, Guo J, Lan X, et al. Promoting scopolamine biosynthesis in transgenic Atropa belladonna plants with pmt and h6h overexpression under field conditions. Plant Physiol Biochem. 2016;106:46-53 pubmed publisher
    ..2.1.1.53) from Nicotiana tabacum (NtPMT) and hyoscyamine 6?-hydroxylase (EC. 1.14.11.14) from Hyoscyamus niger (HnH6H) were overexpressed, were established to investigate TA biosynthesis and distribution in ripe ..
  5. Jeppesen A, Soelberg J, Jäger A. Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan. Plants (Basel). 2012;1:74-81 pubmed publisher
    ..5 µg/mL), Dragocephalum paulsenii (IC50: 0.5 µg/mL), Ephedra intermedia (IC50: 3.8 µg/mL), Hyoscyamus pusillus, Nepeta parmiriensis (IC50: 0.7 µg/mL) and Rumex patientia subsp. pamiricus (IC50: 3...
  6. Jan S, Kamili A, Parray J, Bedi Y, Ahmad P. Microclimatic variation in UV perception and related disparity in tropane and quinolizidine alkaloid composition of Atropa acuminata, Lupinus polyphyllus and Hyoscyamus niger. J Photochem Photobiol B. 2016;161:230-5 pubmed publisher
    ..Atropa acuminata, Lupinus polyphyllus and Hyoscyamus niger to the winter period characterised by intense UV flux in Kashmir valley across the North Western Himalaya...
  7. Lan X, Zeng J, Liu K, Zhang F, Bai G, Chen M, et al. Comparison of two hyoscyamine 6β-hydroxylases in engineering scopolamine biosynthesis in root cultures of Scopolia lurida. Biochem Biophys Res Commun. 2018;497:25-31 pubmed publisher
    ..The hyoscyamine 6β-hydroxylase genes of Hyoscyamus niger (HnH6H) and S. lurida (SlH6H) were cloned and respectively overexpressed in hairy root cultures of S...
  8. Maleki T, Akhani H. Ethnobotanical and ethnomedicinal studies in Baluchi tribes: A case study in Mt. Taftan, southeastern Iran. J Ethnopharmacol. 2018;217:163-177 pubmed publisher
    ..ethnobotanical references in Iran revealed that medicinal applications of 34 taxa have not been cited, including Hyoscyamus malekianus, a local endemic plant using for ailments of toothache and worms...
  9. Hatami M, Hadian J, Ghorbanpour M. Mechanisms underlying toxicity and stimulatory role of single-walled carbon nanotubes in Hyoscyamus niger during drought stress simulated by polyethylene glycol. J Hazard Mater. 2017;324:306-320 pubmed publisher
    In this study, seeds of Hyoscyamus niger were exposed to different concentrations (50-800?gmL-1) of single-walled carbon nanotubes (SWCNTs) under different levels of drought stress (0.5-1.5MPa) for 14days...
  10. Dehghan E, Reed D, Covello P, Hasanpour Z, Palazon J, Oksman Caldentey K, et al. Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids. Plant Cell Rep. 2017;36:1615-1626 pubmed publisher
    ..Transgenic hairy root cultures of Hyoscyamus senecionis were also established. While overexpression of pmt in H...
  11. Sengupta T, Vinayagam J, Nagashayana N, Gowda B, Jaisankar P, Mohanakumar K. Antiparkinsonian effects of aqueous methanolic extract of Hyoscyamus niger seeds result from its monoamine oxidase inhibitory and hydroxyl radical scavenging potency. Neurochem Res. 2011;36:177-86 pubmed publisher
    b>Hyoscyamus species is one of the four plants used in Ayurveda for the treatment of Parkinson's disease (PD)...
  12. Higa A, Khandakar J, Mori Y, Kitamura Y. Increased de novo riboflavin synthesis and hydrolysis of FMN are involved in riboflavin secretion from Hyoscyamus albus hairy roots under iron deficiency. Plant Physiol Biochem. 2012;58:166-73 pubmed publisher
    Riboflavin secretion by Hyoscyamus albus hairy roots under Fe deficiency was examined to determine where riboflavin is produced and whether production occurs via an enhancement of riboflavin biosynthesis or a stimulation of flavin ..
  13. Schlappi M. Genetic and physiological analysis of biennialism in Hyoscyamus niger. Plant Biol (Stuttg). 2011;13:534-40 pubmed publisher
    A genetic and physiological study of biennialism in the diploid selfer Hyoscyamus niger (black henbane), an obligate long-day plant, is described...
  14. Abdel Motaal F, Nassar M, El Zayat S, el Sayed M, Ito S. Responses of fungi to tropane alkaloids produced by a medicinal plant Hyoscyamus muticus (Egyptian henbane). Folia Microbiol (Praha). 2009;54:207-12 pubmed publisher
    ..Hcy feeding experiments using Penicillium purpurogenum (type II) and Cunninghamella elegans (type III) revealed that these fungi may convert Hcy to a new alkaloid compound...
  15. Xia L, Bai L, Chu C, Li P, Jiang Z, Zhao Z. Authentication of the 31 species of Toxic and Potent Chinese Materia Medica (T/PCMM) by microscopic technique, part 2: Three species of seed T/PCMM. Microsc Res Tech. 2008;71:325-33 pubmed publisher
    ..The present study deals with detailed investigations on three species of seed T/PCMM, namely Semen Hyoscyami (Hyoscyamus niger L.), Semen Euphorbiae (Euphorbia lathyris L.), and Semen Strychni (Strychnos nux-vomica L.)...
  16. Sajeli B, Sahai M, Suessmuth R, Asai T, Hara N, Fujimoto Y. Hyosgerin, a new optically active coumarinolignan, from the seeds of Hyoscyamus niger. Chem Pharm Bull (Tokyo). 2006;54:538-41 pubmed
    ..along with three other coumarinolignans, venkatasin, cleomiscosin A and cleomiscosin B, from the seeds of Hyoscyamus niger L. The structure was determined on the basis of spectroscopic analysis and chemical conversion...
  17. Moyano E, Palazon J, Bonfill M, Osuna L, Cusido R, Oksman Caldentey K, et al. Biotransformation of hyoscyamine into scopolamine in transgenic tobacco cell cultures. J Plant Physiol. 2007;164:521-4 pubmed
    ..We report the establishment of tobacco cell cultures carrying the Hyoscyamus muticus h6h gene under the control of the promoter CAMV 35S...
  18. Begum A, Verma S, Sahai M, Schneider K, Süssmuth R. Hyoscyamal, a new tetrahydrofurano lignan from Hyoscyamus niger Linn. Nat Prod Res. 2009;23:595-600 pubmed publisher
    ..three other compounds, balanophonin, pongamoside C and pongamoside D have been isolated from the seeds of Hyoscyamus niger. The structures of the compounds were settled on the basis of spectroscopic analysis...
  19. Jiang K, Pi Y, Huang Z, Hou R, Zhang Z, Lin J, et al. Molecular cloning and mRNA expression profiling of the first specific jasmonate biosynthetic pathway gene allene oxide synthase from Hyoscyamus niger. Genetika. 2009;45:496-505 pubmed
    ..enhance the production of pharmaceutically valuable tropane alkaloids including hyoscyamine and scopolamine in Hyoscyamus niger, methyl jasmonate (MeJA) showed significant stimulation both in tropane biosynthetic pathway enzymes ..
  20. Bourebaba L, Saci S, Touguit D, Gali L, Terkmane S, Oukil N, et al. Evaluation of antidiabetic effect of total calystegines extracted from Hyoscyamus albus. Biomed Pharmacother. 2016;82:337-44 pubmed publisher
    b>Hyoscyamus albus L. (Solanaceae) an old medicinal plant is a rich source of tropane and nortropane alkaloids which confers to this plant a number of very interesting and beneficial therapeutic effects...
  21. Kawauchi M, Kawauchi M, Arima T, Shirota O, Sekita S, Nakane T, et al. Production of sesquiterpene-type phytoalexins by hairy roots of Hyoscyamus albus co-treated with cupper sulfate and methyl jasmonate. Chem Pharm Bull (Tokyo). 2010;58:934-8 pubmed
    The production of sesquiterpene-type phytoalexins with a vetispyradiene skeleton by Hyoscyamus albus hairy roots induced by methyl jasmonate (MeJA) was reported in a previous paper...
  22. Zhang W, Luo J, Kong L. Phytotoxicity of lignanamides isolated from the seeds of Hyoscyamus niger. J Agric Food Chem. 2012;60:1682-7 pubmed publisher
    Bioassay-guided fractionation of phytotoxic extracts prepared from the seeds of Hyoscyamus niger led to the isolation of three new lignanamides (1-3), along with six known lignanamides (4-9)...
  23. El Bazaoui A, Bellimam M, Lançar I, Soulaymani A. Gas-liquid chromatography-mass spectrometry investigation of tropane alkaloids in Hyoscyamus albus L. from Morocco. Z Naturforsch C. 2012;67:461-5 pubmed
    Thirty-four alkaloids were identified in the organs of Hyoscyamus albus L. by gas-liquid chromatography-mass spectrometry (GLC-MS)...
  24. Djilani A, Legseir B. Extraction of atropine by ultrasounds in different solvent systems. Fitoterapia. 2005;76:148-52 pubmed
    The use of ultrasounds for extraction of atropine from Egyptian henbane (Hyoscyamus muticus) has been studied. The kinetic of extraction using various solvent systems was carried out...
  25. Kadi K, Yahia A, Hamli S, Auidane L, Khabthane H, Ali W. In vitro antibacterial activity and phytochemical analysis of White henbane treated by phytohormones. Pak J Biol Sci. 2013;16:984-90 pubmed
    ..the effect of interaction between cytokinins and auxins to enhance accumulation of alkaloids in White henbane (Hyoscyamus albus L.)...
  26. Aslan S, Cakir Z, Emet M, Aksakal E, Akoz A, Uzkeser M. Wildflower (Hyoscyamus reticulatus) causes QT prolongation. Bratisl Lek Listy. 2013;114:333-6 pubmed
    ..Among all plants with anticholinergic effect, Hyoscyamus reticulatus is a species whose clinicopathological effects have been poorly described in literature...
  27. Xiong C, Hu Z, Tu Y, Liu H, Wang P, Zhao M, et al. ITS2 barcoding DNA region combined with high resolution melting (HRM) analysis of Hyoscyami Semen, the mature seed of Hyoscyamus niger. Chin J Nat Med. 2016;14:898-903 pubmed publisher
    Hyoscyami Semen, the mature dried seed of Hyoscyamus niger L., has long been used as a traditional Chinese medicine to treat human diseases. Hyoscyami Semen is found in local markets in China...
  28. Doneray H, Orbak Z, Karakelleoglu C. Clinical outcomes in children with hyoscyamus niger intoxication not receiving physostigmine therapy. Eur J Emerg Med. 2007;14:348-50 pubmed
    Diagnosis of hyoscyamus niger intoxication is based on clinical symptomatology and history. Therapy includes stomach lavage, supportive therapy, and physostigmine as a specific antidote. Physostigmine is not available in Turkey...
  29. Li R, Reed D, Liu E, Nowak J, Pelcher L, Page J, et al. Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement. Chem Biol. 2006;13:513-20 pubmed
    Tropane alkaloids are valuable pharmaceutical drugs derived from solanaceous plants such as Hyoscyamus niger (black henbane)...
  30. Sako A, Kandakar J, Tamari N, Higa A, Yamaguchi K, Kitamura Y. Copper excess promotes propagation and induces proteomic change in root cultures of Hyoscyamus albus L. Plant Physiol Biochem. 2016;103:1-9 pubmed publisher
    b>Hyoscyamus albus L. seedlings respond positively to copper (Cu) excess...
  31. Zhang W, Zhang W, Luo J, Kong L. A new steroidal glycoside from the seeds of Hyoscyamus niger. Nat Prod Res. 2013;27:1971-4 pubmed publisher
    ..together with two known analogues hyoscyamoside E (2) and hyoscyamoside F1 (3), was isolated from the seeds of Hyoscyamus niger...
  32. O Maille P, Malone A, Dellas N, Andes Hess B, Smentek L, Sheehan I, et al. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol. 2008;4:617-23 pubmed publisher
    ..substitutions that functionally interconverted orthologous sesquiterpene synthases from Nicotiana tabacum and Hyoscyamus muticus, we created a library of all possible residue combinations (2(9) = 512) in the N. tabacum enzyme...
  33. Seskauskaite D, Gliwa B. Some Lithuanian ethnobotanical taxa: a linguistic view on thorn apple and related plants. J Ethnobiol Ethnomed. 2006;2:13 pubmed
    ..The perception and use of plants correspond with common plant names. The study of plant names may give insight into historical and recent use of plants...
  34. Begum S, Saxena B, Goyal M, Ranjan R, Joshi V, Rao C, et al. Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan. Fitoterapia. 2010;81:178-84 pubmed publisher
    A chemical and biological validation of the traditional use of Hyoscyamus niger seeds as anti-inflammatory drug has been established. The methanolic extract of seeds of H...
  35. Dehghan E, Shahriari Ahmadi F, Ghotbi Ravandi E, Reed D, Covello P, Bahrami A. An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis. Plant Physiol Biochem. 2013;70:188-94 pubmed publisher
    ..a bifunctional enzyme catalyzing the last two steps in the scopolamine biosynthetic pathway, was isolated from Hyoscyamus senecionis, a medicinal plant endemic to the Iranian plateau...
  36. Ramakrishnan D, Curtis W. Trickle-bed root culture bioreactor design and scale-up: growth, fluid-dynamics, and oxygen mass transfer. Biotechnol Bioeng. 2004;88:248-60 pubmed
    ..Bioreactor characterization is sufficient to carry out preliminary design calculations that indicate scale-up feasibility to at least 10,000 liters...
  37. Mino Y, Yukita M, Hiratsuka N, Wariishi H. Amino acid sequences of ferredoxins from Atropa belladonna and Hyoscyamus niger: their similarities to those in other tropane-alkaloid-containing plants. Biol Pharm Bull. 2005;28:1535-8 pubmed
    The complete amino acid sequences of [2Fe-2S] ferredoxin from Atropa belladonna and Hyoscyamus niger have been determined by automated Edman degradation of the entire S-carboxymethylcysteinyl proteins and of the peptides obtained by ..
  38. Higa A, Mori Y, Kitamura Y. Iron deficiency induces changes in riboflavin secretion and the mitochondrial electron transport chain in hairy roots of Hyoscyamus albus. J Plant Physiol. 2010;167:870-8 pubmed publisher
    b>Hyoscyamus albus hairy roots secrete riboflavin under Fe-deficient conditions...
  39. Schenk D, Starks C, Manna K, Chappell J, Noel J, Coates R. Stereochemistry and deuterium isotope effects associated with the cyclization-rearrangements catalyzed by tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases, and the chimeric CH4 hybrid cyclase. Arch Biochem Biophys. 2006;448:31-44 pubmed
    Tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases (TEAS and HPS) catalyze the cyclizations and rearrangements of (E,E)-farnesyl diphosphate (FPP) to the corresponding bicyclic sesquiterpene hydrocarbons...
  40. Takahashi S, Yeo Y, Zhao Y, O Maille P, Greenhagen B, Noel J, et al. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem. 2007;282:31744-54 pubmed
    ..We report here the characterization of a single cytochrome P450 enzyme, Hyoscyamus muticus premnaspirodiene oxygenase (HPO), that catalyzes these successive reactions at carbon 2 (C-2) of the ..
  41. Vidovic D, Brecić P, Haid A, Jukic V. [Intoxication with henbane]. Lijec Vjesn. 2005;127:22-3 pubmed
    Henbane, Hyoscyamus niger, is a hallucinogenic plant, widely spread and easy accessible, which contains anticholinergic substances...
  42. Cysarz D, Heckmann C, Bettermann H, Kümmell H. Effects of an anthroposophical remedy on cardiorespiratory regulation. Altern Ther Health Med. 2002;8:78-83 pubmed
    ..If this ability is disturbed, eg, in cases of orthostatic syndrome with purely functional disorders, an herbal remedy based on anthroposophical medicine may be able to regulate such rhythmic disturbances...
  43. Jiang K, Liao Z, Pi Y, Huang Z, Hou R, Cao Y, et al. [Molecular cloning and expression profile of a jasmonate biosynthetic pathway gene allene oxide cyclase from Hyoscyamus niger]. Mol Biol (Mosk). 2008;42:434-44 pubmed
    b>Hyoscyamus niger L. is a medicinal plant which produces a class of jasmonate-responsive pharmaceutical secondary metabolites named as tropane alkaloids...
  44. Lee M. Solanaceae III: henbane, hags and Hawley Harvey Crippen. J R Coll Physicians Edinb. 2006;36:366-73 pubmed
    b>Hyoscyamus, the henbane, is one of the drugs of the ancients. Initially used both as a poison and narcotic, it was widely adopted by witches, wizards and soothsayers as a component of their hallucinatory and flying ointments...