zanthoxylum

Summary

Summary: A plant genus of the family RUTACEAE. Some members of Zanthoxylum are reclassified from ELEUTHEROCOCCUS, Melicope, and EVODIA. The twigs are used as dental brushing sticks (TOOTHBRUSHING). Most plants that are called Fagara have been reclassified as Zanthoxylum, however some Fagara were reclassified to MELICOPE (also in the Rutacea family) or to GLEDITSIA (a genus in the FABACEAE family).

Top Publications

  1. Bafi Yeboa N, Arnason J, Baker J, Smith M. Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill. Phytomedicine. 2005;12:370-7 pubmed
    Leaf, fruit, stem, bark and root of Zanthoxylum americanum were investigated for antifungal activity with 11 strains of fungi representing diverse opportunistic and systemic pathogens, including Candida albicans, Cryptococcus neoformans ..
  2. Martin M, Rasoanaivo L, Raharisololalao A. Phenanthridine alkaloids from Zanthoxylum madagascariense. Fitoterapia. 2005;76:590-3 pubmed
    Four benzo[c]phenanthridine alkaloids have been isolated from the stem bark of Zanthoxylum madagascariense. These compounds were identified by extensive use of NMR spectroscopy.
  3. Gibbons S, Leimkugel J, Oluwatuyi M, Heinrich M. Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA). Phytother Res. 2003;17:274-5 pubmed
    ..ef flux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis...
  4. Tatsadjieu L, Essia Ngang J, Ngassoum M, Etoa F. Antibacterial and antifungal activity of Xylopia aethiopica, Monodora myristica, Zanthoxylum xanthoxyloi;des and Zanthoxylum leprieurii from Cameroon. Fitoterapia. 2003;74:469-72 pubmed
    The essential oils of Xylopia aethiopica, Monodora myristica, Zanthoxylum xanthoxyloïdes and Z. leprieurii, four Cameroonian plants used as spices in local food, showed antibacterial and antifungal activity.
  5. Hu J, Zhang W, Liu R, Zhang C, Shen Y, Li H, et al. Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities. Chem Biodivers. 2006;3:990-5 pubmed
    Seven benzophenanthridine alkaloids, 1-7, were isolated from the roots of Zanthoxylum nitidum...
  6. Tane P, Wabo H, Connolly J. A new benzophenanthridine alkaloid from Zanthoxylum buesgenii. Fitoterapia. 2005;76:656-60 pubmed
    ..named buesgeniine (1), as well as the known decarine, were isolated from the extract of the stem bark of Zanthoxylum buesgenii...
  7. Gilani S, Khan A, Gilani A. Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders. Phytother Res. 2010;24:553-8 pubmed publisher
    This study describes the gut, airways and cardiovascular modulatory activities of Zanthoxylum armatum DC. (Rutaceae) to rationalize some of its medicinal uses. The crude extract of Zanthoxylum armatum (Za...
  8. Artaria C, Maramaldi G, Bonfigli A, Rigano L, Appendino G. Lifting properties of the alkamide fraction from the fruit husks of Zanthoxylum bungeanum. Int J Cosmet Sci. 2011;33:328-33 pubmed publisher
    The fruits of various Zanthoxylum species are used as a spice in the Chinese and Japanese cuisine because of their delicate flavour and tingling properties...
  9. Talontsi F, Facey P, Tatong M, Tofazzal Islam M, Frauendorf H, Draeger S, et al. Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp. of Zanthoxylum leprieurii. Phytochemistry. 2012;83:87-94 pubmed publisher
    ..an endophytic fungus from leaves and branches of Zanthoxylum leprieurii (Rutaceae)...

More Information

Publications103 found, 100 shown here

  1. Gwon S, Ahn J, Kim T, Ha T. Zanthoxylum piperitum DC ethanol extract suppresses fat accumulation in adipocytes and high fat diet-induced obese mice by regulating adipogenesis. J Nutr Sci Vitaminol (Tokyo). 2012;58:393-401 pubmed
    This study was conducted to determine the anti-obesity effects of Zanthoxylum piperitum DC fruit ethanol extract (ZPE) in 3T3-L1 adipocytes and obese mice fed a high-fat diet...
  2. Paik S, Koh K, Beak S, Paek S, Kim J. The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Biol Pharm Bull. 2005;28:802-7 pubmed
    The volatile extract from dried pericarp of Zanthoxylum schinifolium that was obtained by simultaneous distillation with dichloromethane and water was composed of 29.9% geranyl acetate, 15.8% citronella, 15...
  3. Cheng M, Lee K, Tsai I, Chen I. Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorg Med Chem. 2005;13:5915-20 pubmed
    ..1) and 10alpha-methoxycadinan-4-en-3-one (2), were isolated from the root bark of Zanthoxylum ailanthoides. The structures of 1 and 2 were elucidated from spectroscopic data...
  4. Huang H, Ishikawa T, Peng C, Tsai I, Chen I. Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity. J Nat Prod. 2008;71:1146-51 pubmed publisher
    Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of 11 new compounds, wutaiensol methyl ether (1), demethoxywutaiensol methyl ether (2), methyl wutaiensate (3), methyl 7-hydroxyanodendroate (4),..
  5. Yoshida T, Nagai H, Yahara T, Tachida H. Genetic structure and putative selective sweep in the pioneer tree, Zanthoxylum ailanthoides. J Plant Res. 2010;123:607-16 pubmed publisher
    b>Zanthoxylum ailanthoides Siebold & Zucc. is one of the most frequently encountered pioneer trees in Japanese warm-temperate evergreen oak forests...
  6. Wang C, Yang K, Zhang H, Cao J, Fang R, Liu Z, et al. Components and insecticidal activity against the maize weevils of Zanthoxylum schinifolium fruits and leaves. Molecules. 2011;16:3077-88 pubmed publisher
    In our screening program for new agrochemicals from Chinese medicinal herbs and wild plants, Zanthoxylum schinifolium essential oils were found to possess strong insecticidal activity against the maize weevil Sitophilus zeamais...
  7. Lee S, Lim K. Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Toxicol In Vitro. 2008;22:376-85 pubmed
    ..was carried out to investigate the anti-oxidative and hepatoprotective effects of glycoprotein isolated from Zanthoxylum piperitum DC fruit (ZPDC glycoprotein)...
  8. Cao L, Lee Y, Kang D, Kim J, Lee H. Effect of Zanthoxylum schinifolium on TNF-alpha-induced vascular inflammation in human umbilical vein endothelial cells. Vascul Pharmacol. 2009;50:200-7 pubmed publisher
    ..In this study, we evaluated an ethanol extract of Zanthoxylum schinifolium (EZS) to determine if it inhibits the expressions of cellular adhesion molecules in human ..
  9. Pereira S, Lopes L, Marques R, Figueiredo K, Costa D, Chaves M, et al. Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents. J Ethnopharmacol. 2010;129:227-31 pubmed publisher
    b>Zanthoxylum rhoifolium Lam. (Rutaceae) is locally known as "mamica de cadela", and its bark is popularly used for toothache and earache...
  10. Yang L, Li R, Tan J, Jiang Z. Polyphenolics composition of the leaves of Zanthoxylum bungeanum Maxim. grown in Hebei, China, and their radical scavenging activities. J Agric Food Chem. 2013;61:1772-8 pubmed publisher
    ..HPLC-ESI-MS/MS) was used to identify the polyphenols from the leaves of a traditional vegetable and spice, Zanthoxylum bungeanum Maxim...
  11. Ahmad M, Rahman M, Huq E, Chowdhury R. Alkaloids of Zanthoxylum budrunga. Fitoterapia. 2003;74:191-3 pubmed
    Pseudophrynamine, lunacridine and the new compound 2-(2',4',6'-trimethyl-heptenyl)-4-quinozolone were isolated from the leaves of Zanthoxylum budrunga.
  12. Kamsuk K, Choochote W, Chaithong U, Jitpakdi A, Tippawangkosol P, Riyong D, et al. Effectiveness of Zanthoxylum piperitum-derived essential oil as an alternative repellent under laboratory and field applications. Parasitol Res. 2007;100:339-45 pubmed
    ..In this study, Zanthoxylum piperitum-derived essential oil isolated by steam distillation was investigated and compared to the standard ..
  13. Yang X. Aroma constituents and alkylamides of red and green huajiao (Zanthoxylum bungeanum and Zanthoxylum schinifolium). J Agric Food Chem. 2008;56:1689-96 pubmed publisher
    Huajiao denotes the fruits of various species of Zanthoxylum in the plant family Rutaceare used for cooking. The two most commercially popular species are bungeanum (red huajiao) and schinifolium (green huajiao)...
  14. Ranawat L, Bhatt J, Patel J. Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. J Ethnopharmacol. 2010;127:777-80 pubmed publisher
    b>Zanthoxylum armatum DC is described as a hepatoprotective in Ayurveda, the Indian system of medicine. However, there is no scientific basis or reports in the modern literature regarding its usefulness as a hepatoprotective agent...
  15. Dung T, Chang H, Binh T, Lee M, Tsai C, Tsai F, et al. Zanthoxylum avicennae extracts inhibit cell proliferation through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells in vitro and in vivo. Int J Mol Med. 2012;29:1045-52 pubmed publisher
    ..In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell proliferation...
  16. de A Gonzaga W, Weber A, Giacomelli S, Dalcol I, Hoelzel S, Morel A. Antibacterial alkaloids from Zanthoxylum rhoifolium. Planta Med. 2003;69:371-4 pubmed
    ..dioxolo[4',5':4,5]benzo[c]phenanthridine (2) were isolated from the stem bark of Zanthoxylum rhoifolium, together with four other previously known benzophenanthridine alkaloids, 6-acetonyldihydronitidine (..
  17. Jeong C, Shim K. Tyrosinase inhibitor isolated from the leaves of Zanthoxylum piperitum. Biosci Biotechnol Biochem. 2004;68:1984-7 pubmed
    Two flavonols, quercetin (1) and quercitrin (2), were isolated from the leaves of Zanthoxylum piperitum. Their structures were established by UV, one- and two-dimensional NMR, and mass spectroscopic methods...
  18. Jullian V, Bourdy G, Georges S, Maurel S, Sauvain M. Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam. J Ethnopharmacol. 2006;106:348-52 pubmed
    b>Zanthoxylum rhoifolium bark (Rutaceae) is a medicinal plant, traditionally used in French Guiana to treat and prevent malaria...
  19. Ma Y, Zhang J, Chen S. Paenibacillus zanthoxyli sp. nov., a novel nitrogen-fixing species isolated from the rhizosphere of Zanthoxylum simulans. Int J Syst Evol Microbiol. 2007;57:873-7 pubmed
    Five endospore-forming, nitrogen-fixing strains were isolated from rhizosphere soils of Zanthoxylum simulans planted in Beijing, China...
  20. Guo T, Deng Y, Xie H, Yao C, Cai C, Pan S, et al. Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice. Fitoterapia. 2011;82:347-51 pubmed publisher
    b>Zanthoxylum armatum DC. is a traditional Chinese medicine that is prescribed to alleviate pain and treat inflammatory disorders. This species is distributed mainly in the southeast and southwest regions of China...
  21. Lima L, Perazzo F, Tavares Carvalho J, Bastos J. Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark. J Pharm Pharmacol. 2007;59:1151-8 pubmed
    ..the anti-inflammatory and analgesic properties of the leaves (LCE) and stem bark (BCE) crude extracts of Zanthoxylum riedelianum (Rutaceae)...
  22. Tiwary M, Naik S, Tewary D, Mittal P, Yadav S. Chemical composition and larvicidal activities of the essential oil of Zanthoxylum armatum DC (Rutaceae) against three mosquito vectors. J Vector Borne Dis. 2007;44:198-204 pubmed
    ..this study was undertaken to assess the larvicidal potential of the essential oil from the seeds of Zanthoxylum armatum DC [syn. Z...
  23. Yang F, Su Y, Li X, Zhang Q, Sun R. Studies on the preparation of biodiesel from Zanthoxylum bungeanum Maxim seed oil. J Agric Food Chem. 2008;56:7891-6 pubmed publisher
    To reduce the cost of biodiesel production, the feasibility of Zanthoxylum bungeanum Maxim seed oil (ZBMSO) was studied to produce biodiesel...
  24. Chen J, Chung C, Hwang T, Chen J. Amides and benzenoids from Zanthoxylum ailanthoides with inhibitory activity on superoxide generation and elastase release by neutrophils. J Nat Prod. 2009;72:107-11 pubmed publisher
    ..5), and 17 known compounds have been isolated from the stem bark of Zanthoxylum ailanthoides. The structures were determined through spectroscopic and MS analyses...
  25. Hieu T, Kim S, Kwon H, Ahn Y. Enhanced repellency of binary mixtures of Zanthoxylum piperitum pericarp steam distillate or Zanthoxylum armatum seed oil constituents and Calophyllum inophyllum nut oil and their aerosols to Stomoxys calcitrans. Pest Manag Sci. 2010;66:1191-8 pubmed publisher
    The repellency to stable fly, Stomoxys calcitrans (L.), of Zanthoxylum piperitum (L...
  26. Mansoor T, Borralho P, Luo X, Mulhovo S, Rodrigues C, Ferreira M. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells. Phytomedicine. 2013;20:923-9 pubmed publisher
    ..alkaloids (1-9) and lignans (10-13), isolated from the methanol extract of roots of the African medicinal plant Zanthoxylum capense, were assayed for their ability as apoptosis inducers in HCT116 colon carcinoma cells...
  27. Li Y, Zeng J, Liu L, Jin X. [GC-MS analysis of supercritical carbon dioxide extraction products from pericarp of Zanthoxylum bungeanum]. Zhong Yao Cai. 2001;24:572-3 pubmed
    The chemical constituents of supercritical carbon dioxide extraction products from pericarp of Zanthoxylum bungeanun Maxim. were studied by GC-MS-DS. Forty-five compounds which account for 86...
  28. de Abreu Gonzaga W, Weber A, Giacomelli S, Simionatto E, Dalcol I, Dessoy E, et al. Composition and antibacterial activity of the essential oils from Zanthoxylum rhoifolium. Planta Med. 2003;69:773-5 pubmed
    The essential oils from the aerial parts of leaves, fruits and flowers of Zanthoxylum rhoifolium of Southern Brazil (Rio Grande do Sul), were analysed by GC, GC/MS, and chiral phase gas chromatography (CPGC)...
  29. Kusuda M, Inada K, Ogawa T, Yoshida T, Shiota S, Tsuchiya T, et al. Polyphenolic constituent structures of Zanthoxylum piperitum fruit and the antibacterial effects of its polymeric procyanidin on methicillin-resistant Staphylococcus aureus. Biosci Biotechnol Biochem. 2006;70:1423-31 pubmed
    b>Zanthoxylum piperitum (Rutaceae) is used as a spice and a natural medicine in Japan...
  30. Chou S, Peng H, Chang C, Yang J, Chung H, Yang S, et al. Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. Anticancer Res. 2011;31:1667-76 pubmed
    The effects of 50% ethanolic stem extracts of Zanthoxylum ailanthoides Sieb and Zucc. (ZASZ) on the cell viability, cell cycle and apoptosis were investigated in a human colon adenocarcinoma cell line (colo 205)...
  31. Dung T, Chang H, Chen C, Peng W, Tsai C, Tsai F, et al. Zanthoxylum avicennae extracts induce cell apoptosis through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells and block tumor growth in xenografted nude mice. Int J Mol Med. 2011;28:927-36 pubmed publisher
    ..Whether Zanthoxylum avicennae (Ying Bu Bo, YBB) induces liver cancer cell apoptosis remains unclear...
  32. Misra L, Wouatsa N, Kumar S, Venkatesh Kumar R, Tchoumbougnang F. Antibacterial, cytotoxic activities and chemical composition of fruits of two Cameroonian Zanthoxylum species. J Ethnopharmacol. 2013;148:74-80 pubmed publisher
    b>Zanthoxylum leprieurii (Syn. Fagara leprieurii) is a plant extensively used by traditional healers in Cameroon for the treatment of stomach disorders, gonorrhea, intestinal parasites and sterility...
  33. Dossou K, Devkota K, Morton C, Egan J, Lu G, Beutler J, et al. Identification of CB1/CB2 ligands from Zanthoxylum bungeanum. J Nat Prod. 2013;76:2060-4 pubmed publisher
    ..in the present study screening for CB1/CB2 receptor activity of extracts for several species of the plant genus Zanthoxylum. The objective of this screen was to identify novel antagonists of the CB1 receptor, which simultaneously ..
  34. Diéguez Hurtado R, Garrido Garrido G, Prieto González S, Iznaga Y, Gonzalez L, Molina Torres J, et al. Antifungal activity of some Cuban Zanthoxylum species. Fitoterapia. 2003;74:384-6 pubmed
    Ethanolic extracts of the trunk bark of Zanthoxylum fagara, Z. elephantiasis and Z. martinicense showed activity against different species of fungi. No antibacterial activity was detected.
  35. Olila D, Olwa Odyek -, Opuda Asibo J. Antibacterial and antifungal activities of extracts of Zanthoxylum chalybeum and Warburgia ugandensis, Ugandan medicinal plants. Afr Health Sci. 2001;1:66-72 pubmed
    ..In this study, the efficacy of Warburgia ugandensis and Zanthoxylum chalybeum against common bacteria and fungi was investigated...
  36. Jun D, Kim J, Park H, Han C, Fang Z, Woo M, et al. Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade. Carcinogenesis. 2007;28:1303-13 pubmed
    ..isolate pharmacologically safe compounds that can induce apoptosis of tumor cells, leaves of an aromatic plant (Zanthoxylum schinifolium), which are widely used as a food flavor and herbal medicine in Korea and Japan, were sequentially ..
  37. Detoni C, Cabral Albuquerque E, Hohlemweger S, Sampaio C, Barros T, Velozo E. Essential oil from Zanthoxylum tingoassuiba loaded into multilamellar liposomes useful as antimicrobial agents. J Microencapsul. 2009;26:684-91 pubmed publisher
    b>Zanthoxylum tingoassuiba essential oil (EO) is a complex mixture of organic compounds among which methyl-N-methylanthranilate and sesquiterpene alcohol alpha-bisabolol represent the main compounds...
  38. Ferreira M, Cebrián Torrejón G, Corrales A, Vera de Bilbao N, Rolon M, Gomez C, et al. Zanthoxylum chiloperone leaves extract: first sustainable Chagas disease treatment. J Ethnopharmacol. 2011;133:986-93 pubmed publisher
    b>Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) stem bark is used traditionally in Paraguay for its antiparasitic properties...
  39. Song L, Liu Y. [Comparative study of HPLC fingerprint between Zanthoxylum bungeanum and Zanthoxylum schinifolium]. Zhong Yao Cai. 2012;35:39-42 pubmed
    To establish the HPLC fingerprint of Zanthoxylum bungeanum and Zanthoxylum schinifolium for finding the difference. Samples were extracted with 50% methanol 25 mL by ultrasonic wave and then separated on Hypersil BDS C18 (250 mm x 4...
  40. Nozaki R, Kono T, Bochimoto H, Watanabe T, Oketani K, Sakamaki Y, et al. Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells. Oncotarget. 2016;7:70437-70446 pubmed publisher
    b>Zanthoxylum fruit, obtained from the Japanese pepper plant (Zanthoxylum piperitum De Candolle), and its extract (Zanthoxylum fruit extract, ZFE) have multiple physiological activities (e.g., antiviral activity)...
  41. Nantongo J, Odoi J, Abigaba G, Gwali S. Variability of phenolic and alkaloid content in different plant parts of Carissa edulis Vahl and Zanthoxylum chalybeum Engl. BMC Res Notes. 2018;11:125 pubmed publisher
    ..post-harvest treatment on total phenolics (TP) and total alkaloids in the leaves and bark of Carissa edulis and Zanthoxylum chalybeum, which would give an indication of the suitability of leaves as alternative sources of medicine in ..
  42. Trongtokit Y, Rongsriyam Y, Komalamisra N, Krisadaphong P, Apiwathnasorn C. Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors. Southeast Asian J Trop Med Public Health. 2004;35:325-33 pubmed
    Oils of Syzygium aromaticum (clove) and Zanthoxylum limonella (makaen), widely used essential oils for dental caries or flavoring of food in Thailand, were prepared as 10 experimental repellent products in gel or cream form against Aedes ..
  43. Hu L, Wang K, Wang Z, Liu J, Wang K, Zhang J, et al. A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc. Molecules. 2016;21:383 pubmed publisher
    b>Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan...
  44. Wu H, Lay I, Shibu M, Ho T, Cheng S, Lin C, et al. Zanthoxylum avicennae extract enhances GSK-3? to attenuate ?-catenin via phosphatase 2A to block metastatic effects of HA22T cells and hepatocellular carcinoma xenografted nude mice. Environ Toxicol. 2017;32:2133-2143 pubmed publisher
    ..b>Zanthoxylum avicennae (Ying Bu Bo, YBB), a traditional herb with hepatoprotective effect, has been proven to inhibit human ..
  45. Menozzi Smarrito C, Riera C, Munari C, le Coutre J, Robert F. Synthesis and evaluation of new alkylamides derived from alpha-hydroxysanshool, the pungent molecule in szechuan pepper. J Agric Food Chem. 2009;57:1982-9 pubmed publisher
    ..The data provide knowledge of the main sanshool chemical functionalities required for TRP channel activation, but they also evidence new selective and potent TRPA1 agonists based on alpha-hydroxysanshool. ..
  46. Wangensteen H, Ho G, Tadesse M, Miles C, Moussavi N, Mikolo B, et al. A new benzophenanthridine alkaloid and other bioactive constituents from the stem bark of Zanthoxylum heitzii. Fitoterapia. 2016;109:196-200 pubmed publisher
    ..9) and sylvamide (10), were isolated as minor compounds from the hexane extract of stem bark from Zanthoxylum heitzii. Four previously reported compounds (1-4) were found, as well...
  47. Fan Q, Zhang H, Hu H, Xu Y, Song Q. Quick method for separating target compounds from the bark of Maqian (Zanthoxylum myriacanthum var. pubescens) by high-performance countercurrent chromatography. J Sep Sci. 2016;39:4049-4052 pubmed publisher
    ..In this study, we introduce a quick method of separating a target compound from the bark of Zanthoxylum myriacanthum var. pubescens by countercurrent chromatography...
  48. Lv C, Wu X, Wang X, Su J, Zeng H, Zhao J, et al. The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs. Sci Rep. 2017;7:352 pubmed publisher
    ..To demonstrate the reliability and utility of our approach, we used nitidine chloride (NC) from the root of Zanthoxylum nitidum, a topoisomerase I/II inhibitor and ?-adrenoreceptor antagonist, as an example to study the molecular ..
  49. Hussain M, Maji T. Preparation of genipin cross-linked chitosan-gelatin microcapsules for encapsulation of Zanthoxylum limonella oil (ZLO) using salting-out method. J Microencapsul. 2008;25:414-20 pubmed publisher
    b>Zanthoxylum limonella oil (ZLO) containing chitosan-gelatin complex microcapsules cross-linked with genipin, a cross-linker of natural origin, have been prepared by a complex coacervation process using the salting-out method...
  50. Alam F, Saqib Q, Ashraf M. Zanthoxylum armatum DC extracts from fruit, bark and leaf induce hypolipidemic and hypoglycemic effects in mice- in vivo and in vitro study. BMC Complement Altern Med. 2018;18:68 pubmed publisher
    b>Zanthoxylum armatum DC is an important medicinal plant of south East Asia, and has been used to treat various ailments in traditional medicine including diabetes...
  51. Mann A, Ifarajimi O, Adewoye A, Ukam C, Udeme E, Okorie I, et al. In vivo antitrypanosomal effects of some ethnomedicinal plants from Nupeland of north central Nigeria. Afr J Tradit Complement Altern Med. 2011;8:15-21 pubmed
    Four medicinal plants Acacia nilotica, Bombax buonopozense, Terminalia avicennioides and Zanthoxylum zanthoxyloides traditionally used for treatment of sleeping sickness in Nupeland were investigated for in vivo antitrypanosomal activity...
  52. Tine Y, Diop A, Diatta W, Desjobert J, Boye C, Costa J, et al. Chemical Diversity and Antimicrobial Activity of Volatile Compounds from Zanthoxylum zanthoxyloides Lam. according to Compound Classes, Plant Organs and Senegalese Sample Locations. Chem Biodivers. 2017;14: pubmed publisher
    The chemical diversity of Zanthoxylum zanthoxyloides growing wild in Senegal was studied according to volatile compound classes, plant organs and sample locations...
  53. Zhang X, Li Q, Chen G, Yang J, Gao X, Song J. [Insect community structure and its stability in a Zanthoxylum bungeanum garden with different planting pattern]. Ying Yong Sheng Tai Xue Bao. 2009;20:1986-91 pubmed
    An investigation was made on the insect community composition and structure in a Zanthoxylum bungeanum garden with corn-soybean - Z. bungeanum intercropping, soybean - Z. bungeanum intercropping, corn - Z...
  54. Adamu M, Naidoo V, Eloff J. Some southern African plant species used to treat helminth infections in ethnoveterinary medicine have excellent antifungal activities. BMC Complement Altern Med. 2012;12:213 pubmed publisher
    ..g. benzimidazoles also have good antifungal activity we examined the antifungal activity of extracts of 13 plant species used in southern Africa to treat gastrointestinal helminth infections in livestock and in man...
  55. Epifano F, Genovese S, Marcotullio M, Curini M. Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp. Mini Rev Med Chem. 2008;8:1203-8 pubmed
    ..The aim of this review is to examine the phytochemical and pharmacological properties of this compound. ..
  56. Ogwang P, Nyafuono J, Agwaya M, Omujal F, Tumusiime H, Kyakulaga A. Preclinical efficacy and safety of herbal formulation for management of wounds. Afr Health Sci. 2011;11:524-9 pubmed
    ..Most herbal products developed by local herbalists and sold to the public are not standardized and lack efficacy and safety data to support use...
  57. Fogang H, Womeni H, Piombo G, Barouh N, Tapondjou L. Bioefficacy of essential and vegetable oils of Zanthoxylum xanthoxyloides seeds against Acanthoscelides obtectus (Say) (Coleoptera: Bruchidae). J Food Prot. 2012;75:547-55 pubmed publisher
    Experiments were conducted in the laboratory to evaluate the bioefficacy of essential and vegetable oils of Zanthoxylum xanthoxyloides (Rutaceae) against Acanthoscelides obtectus (Coleoptera: Bruchidae)...
  58. Sandjo L, de Moraes M, Kuete V, Kamdoum B, Ngadjui B, Steindel M. Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi. Bioorg Med Chem Lett. 2016;26:1772-5 pubmed publisher
    ..This activity increased when 3 (13.63μg/mL) was combined with 1 in ratios 1:1 (10.01μg/mL) and 3:1 (7.78μg/mL). Moreover, the leishmanicidal effect of 4 against L. amazonensis increased in the mixture 6/4 (1:3). ..
  59. Tao Z, Chen W, Zhang W, Sun L, Zheng S, Qiao C. [Coumarins from root of Zanthoxylum dimorphophyllum var. spinifolium]. Zhongguo Zhong Yao Za Zhi. 2005;30:832-4 pubmed
    To study the chemical components from dried roots of Zanthoxylum dimorphophyllum var. spinifoliun. The chemical components were isolated by low pressure column chromatography and their structures were identified by spectroscopic methods...
  60. Lee Y, Yoon J, Lee S, Kim J, Kang D, Lee H. Inhibitory effect of Zanthoxylum schinifolium on vascular smooth muscle proliferation. Immunopharmacol Immunotoxicol. 2012;34:354-61 pubmed publisher
    ..The principal objective of this study was to determine the inhibitory effects of ethanol extract from Zanthoxylum schinifolium (EZS) on human aortic smooth muscle cell (HASMC) proliferation induced by TNF-?...
  61. Ren T, Zhu Y, Xia X, Ding Y, Guo J, Kan J. Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats. J Mol Endocrinol. 2017;58:113-125 pubmed publisher
    This study aimed to evaluate the protein metabolism effect of Zanthoxylum alkylamides and to explore the potential mechanism in streptozotocin (STZ)-induced diabetic rats...
  62. Shen J, Ding X, Zhang W, Bao S, Chang J, Tang F. [Authentication of Zanthexylum bungeanum Maxin population and adulterants by analysis of rDNA ITS sequences]. Yao Xue Xue Bao. 2005;40:80-6 pubmed
    ..bungeanum which have close relationship always distribute in near geographic areas. The characteristics of rDNA ITS sequence can be used as good markers for authenticating Zanthexylum bungeanum populations form their adulterants. ..
  63. Lee S, Lim K. Phytoglycoprotein (24 kDa) inhibits expression of PCNA via PKCalpha and MAPKs in oxygen radical-stimulated Chang liver cells. J Nutr Biochem. 2009;20:96-105 pubmed publisher
    The purpose of this study was to investigate the inhibitory effect of 24-kDa glycoprotein isolated from Zanthoxylum piperitum DC fruit (ZPDC glycoprotein) on glucose/glucose oxidase (G/GO)- or hypoxanthine/xanthine oxidase (HX/XO)-..
  64. Yanase E, Ohno M, Harakawa H, Nakatsuka S. Isolation of N,N-dimethyl and N-methylserotonin 5-O-?-glucosides from immature Zanthoxylum piperitum seeds. Biosci Biotechnol Biochem. 2010;74:1951-2 pubmed
    ..5-O-?-glucoside (1a) and N-methylserotonin 5-O-?-glucoside (1b) were isolated from immature seeds of Zanthoxylum piperitum. Their structures were determined by multi-step conversion reactions and spectroscopic analyses...
  65. Devkota K, Wilson J, Henrich C, McMahon J, Reilly K, Beutler J. Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth. J Nat Prod. 2013;76:59-63 pubmed publisher
    A neurofibromatosis type 1 (NF1)-based bioassay-guided phytochemical investigation on Zanthoxylum armatum collected in Nepal led to the isolation of new timuramides A-D (1-4) and six known sanshools (5-10)...
  66. Park Y, Lee W, An S, Jeong T. Human acyl-CoA: cholesterol acyltransferase inhibitory activities of aliphatic acid amides from Zanthoxylum piperitum DC. Biol Pharm Bull. 2007;30:205-7 pubmed
    ..2), and hydroxy-beta-sanshool (3), were isolated by bioassay-guided fractionation of the ethanolic extracts of Zanthoxylum piperitum DC. Compounds 1 and 2 inhibited human ACAT-1 and -2 activities with IC50 values of 39.0 and 79...
  67. Yang C, Cheng M, Lee S, Yang C, Chang H, Chen I. Secondary metabolites and cytotoxic activities from the stem bark of Zanthoxylum nitidum. Chem Biodivers. 2009;6:846-57 pubmed publisher
    ..e., beta-sitosterol (27) and beta-sitostenone (28) were isolated from the stem bark of Zanthoxylum nitidum. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses...
  68. Lee J, Lim K. Inhibitory effect of phytoglycoprotein (24kDa) on allergy-related factors in compound 48/80-induced mast cells in vivo and in vitro. Int Immunopharmacol. 2010;10:591-9 pubmed publisher
    ..Recently, we isolated and purified glycoprotein from Zanthoxylum piperitum DC fruit (ZPDC), and demonstrated that ZPDC glycoprotein (5-20mg/kg, 25-100mug/ml) has an inhibitory ..
  69. Li Y, Zeng J, Liu L, Jin X. [GC-MS analysis of supercritical carbon dioxide extract from seeds of Zanthoxylum bungeanun Maxim]. Zhong Yao Cai. 2001;24:493-4 pubmed
    The chemical components of supercritical carbon dioxide extracts from seeds of Zanthoxylum bungeanun Maxim. were studied by GC-MS-DS. Thirty-five compounds which account for 96...
  70. Jiang L, Kubota K. Differences in the volatile components and their odor characteristics of green and ripe fruits and dried pericarp of Japanese pepper (Xanthoxylum piperitum DC.). J Agric Food Chem. 2004;52:4197-203 pubmed
    ..In the dried pericarp, the ratio of oxygenated terpenoids was almost equal to that of monoterpene hydrocarbons. These seemed to induce the flavor character of the dried pericarp to be milder than that of the ripe fruit. ..
  71. Walker T, Vogler B, Moriarity D, Haber W, Setzer W. A phytochemical investigation of Zanthoxylum setulosum. Nat Prod Commun. 2011;6:1807-8 pubmed
    The crude bark extract of Zanthoxylum setulosum from Monteverde, Costa Rica was notably cytotoxic (100% kill at 100 microg/mL) to MCF-7, MDA-MB-231, and MDA-MB-468 cells in vitro...
  72. Su G, Cheng Y, Wang K, Wang X, Wu B. An Unusual Tetrahydrofuran Lignan from the Roots of Zanthoxylum planispinum and the Potential Anti-inflammatory Effects. Chem Biodivers. 2017;14: pubmed publisher
    ..7 cells. In particular, compound 1 showed significant inhibitory activity with an IC50 value of 36.8 ?m. ..
  73. Teshima S, Kawakami S, Sugimoto S, Matsunami K, Otsuka H, Shinzato T. Aliphatic Glucoside, Zanthoionic Acid and Megastigmane Glucosides: Zanthoionosides A-E from the Leaves of Zanthoxylum ailanthoides. Chem Pharm Bull (Tokyo). 2017;65:754-761 pubmed publisher
    From the leaves of Zanthoxylum ailanthoides, 4'-O-p-E-coumaric acid esters of 2-propanol ?-D-glucopyranoside, megastigmane and megastigmane glucosides were isolated. Their structures were elucidated by spectroscopic evidence...
  74. Moaddel R, Rosenberg A, Spelman K, Frazier J, Frazier C, Nocerino S, et al. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening. Anal Biochem. 2011;412:85-91 pubmed publisher
    ..The CB1/CB2-OT column was also used to screen a botanical matrix, Zanthoxylum clava-herculis, where preliminary results suggest the presence of a high-affinity phytocannabinoid.
  75. Cao X, Xu J, Bai G, Zhang H, Liu Y, Xiang J, et al. Isolation of anti-tumor compounds from the stem bark of Zanthoxylum ailanthoides Sieb. & Zucc. by silica gel column and counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;929:6-10 pubmed publisher
    ..for the separation of potential anti-tumor compounds from a petroleum ether fraction of a crude extract of Zanthoxylum ailanthoides Sieb. & Zucc...
  76. Melliou E, Magiatis P, Mitaku S, Skaltsounis A, Chinou E, Chinou I. Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. J Nat Prod. 2005;68:78-82 pubmed
    ..The most active compounds were 3, 7, 8, 11, and 14. Some structure-activity relationships are discussed. ..
  77. Lee J, Lim K. Inhibitory effect of phytoglycoprotein (24 kDa) on hepatocarcinogenesis in N-nitrosodiethylamine-treated ICR mice. J Pharm Pharmacol. 2011;63:840-8 pubmed publisher
    ..For a long time in Korea Zanthoxylum piperitum DC (ZPDC) has been used in folk medicine to cure several cancers and inflammation...
  78. Dalling J, Brown T. Long-term persistence of pioneer species in tropical rain forest soil seed banks. Am Nat. 2009;173:531-5 pubmed publisher
    ..We show that seeds of Croton billbergianus, Trema micrantha, and Zanthoxylum ekmannii germinate successfully from surface soil microsites after 38, 31, and 18 years, respectively...
  79. Sabir S, Rocha J, Boligon A, Athayde M. Hepatoprotective activity and phenolic profile of Zanthoxylum alatum Roxb. fruit extract. Pak J Pharm Sci. 2017;30:1551-1556 pubmed
    b>Zanthoxylum alatum Roxb. (Rutaceae) is a medicinal plant, which abundantly grows in the hilly areas of Pakistan. In the present study, the hepatoprotective activity of the Z. alatum whole fruit was evaluated...
  80. Park I, Kim L, Choi I, Lee Y, Shin S. Fumigant activity of plant essential oils and components from Schizonepeta tenuifolia against Lycoriella ingenua (Diptera: Sciaridae). J Econ Entomol. 2006;99:1717-21 pubmed
    ..ingenua was achieved with essential oils of Acorus gramineus Solander, Schizonepeta tenuifolia Briquet, and Zanthoxylum piperitum De Candolle at 25 microg/ml air. S...
  81. Da Silva S, Figueiredo P, Yano T. Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves. Eur J Pharmacol. 2007;576:180-8 pubmed
    In this work, the anti-tumor properties of the volatile oil from Zanthoxylum rhoifolium Lam leaves and some terpenes (alpha-humulene, beta-caryophyllene, alpha-pinene and beta-pinene) were investigated in vitro and in vivo using the ..
  82. Chen J, Chen P, Liao C, Huang S, Chen I. New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum. J Nat Prod. 2007;70:1444-8 pubmed
    ..18-demethylparaensidimerin C (5), together with 17 known compounds have been isolated from the stem wood of Zanthoxylum integrifoliolum...
  83. Inoue K, Naito Y, Takagi T, Hayashi N, Hirai Y, Mizushima K, et al. Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model. Biol Pharm Bull. 2011;34:1659-65 pubmed
    ..These findings suggest that DKT reduces intestinal fibrosis associated with decreasing expression of HSP47 and collagen content in the intestine...
  84. Zhang S, Zhou B, Wang Y. Determination of L-sesamin and L-asarinin in Zanthoxylum(Roxb.) DC. by high performance liquid chromatography. Di Yi Jun Yi Da Xue Xue Bao. 2002;22:654-5 pubmed
    To establish a method for determining the content of L-sesamin and L-asarinin indifferent parts of Zanthoxylum(Roxb.)DC.
  85. Ogwal Okeng J, Obua C, Anokbonggo W. Acute toxicity effects of the methanolic extract of Fagara zanthoxyloides (Lam.) root-bark. Afr Health Sci. 2003;3:124-6 pubmed
    ..Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used extensively in malaria and other infections. However nothing is known about its toxicity...
  86. Ferreira M, Nakayama H, de Arias A, Schinini A, de Bilbao N, Serna E, et al. Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice. J Ethnopharmacol. 2007;109:258-63 pubmed
    Canthin-6-one (1), isolated from Zanthoxylum chiloperone (Rutaceae), possesses a broad sprectum of antifungal and leishmanicidal activities...
  87. Braguine C, Costa E, Magalhaes L, Rodrigues V, da Silva Filho A, Bastos J, et al. Schistosomicidal evaluation of Zanthoxylum naranjillo and its isolated compounds against Schistosoma mansoni adult worms. Z Naturforsch C. 2009;64:793-7 pubmed
    Chemical investigation of the EtOAc fraction (EF) obtained from the ethanolic extract of Zanthoxylum naranjillo (Rutaceae) leaves (EE) by preparative HPLC resulted in the isolation of protocatechuic acid (1), gallic acid (2), p-..
  88. Min B, Hyun D, Jeong S, Kim Y, Ma E, Woo M. A new cytotoxic coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl] oxy coumarin, from the leaves of Zanthoxylum schinifolium. Arch Pharm Res. 2011;34:723-6 pubmed publisher
    ..Compound 1 (IC(50) 8.10 ?M) showed potent cytotoxicity compared to auraptene (IC(50) 55.36 ?M) against Jurkat T cells. The other isolated compounds 2 and 4 exhibited weak cytotoxicities...
  89. Bouquet J, Rivaud M, Chevalley S, Deharo E, Jullian V, Valentin A. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012;11:67 pubmed publisher
    ..The widespread use of these therapies stresses the importance of studying this molecule in the context of malaria control. However, little is known about its potential as an anti-plasmodial drug, as well as its mechanism of action...
  90. Hagura N, Barber H, Haggard P. Food vibrations: Asian spice sets lips trembling. Proc Biol Sci. 2013;280:20131680 pubmed publisher
  91. Li W, Sun Y, Yan X, Yang S, Kim E, Kang H, et al. Coumarins and lignans from Zanthoxylum schinifolium and their anticancer activities. J Agric Food Chem. 2013;61:10730-40 pubmed publisher
    b>Zanthoxylum schinifolium is an aromatic shrub, and its pericarp and leaves are widely used in culinary applications in East Asian countries...
  92. Singh T, Meitei H, Sharma A, Robinson A, Singh L, Singh T. Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC. Biol Res. 2015;48:46 pubmed publisher
    ..Here, we screened 16 medicinal plant extracts from Northeast part of India and found that leaf extract of Zanthoxylum armatum DC...