ruta

Summary

Summary: A plant genus of the family RUTACEAE. Members contain quinoline alkaloids.

Top Publications

  1. Preethi K, Kuttan G, Kuttan R. Anti-tumour activity of Ruta graveolens extract. Asian Pac J Cancer Prev. 2006;7:439-43 pubmed
    An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals...
  2. Raghav S, Gupta B, Shrivastava A, Das H. Inhibition of lipopolysaccharide-inducible nitric oxide synthase and IL-1beta through suppression of NF-kappaB activation by 3-(1'-1'-dimethyl-allyl)-6-hydroxy-7-methoxy-coumarin isolated from Ruta graveolens L. Eur J Pharmacol. 2007;560:69-80 pubmed
    The Ruta graveolens L. plant is used in traditional medicine to treat a large number of diseases...
  3. Raghav S, Gupta B, Agrawal C, Goswami K, Das H. Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells. J Ethnopharmacol. 2006;104:234-9 pubmed
    b>Ruta graveolens L. (Rutaceae) is used for several therapeutic purposes worldwide...
  4. Orlita A, Sidwa Gorycka M, Kumirska J, Malinski E, Siedlecka E, Gajdus J, et al. Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors. Biotechnol Prog. 2008;24:128-33 pubmed
    ..The use of saccharin also increased the production of bergapten, isopimpinelin, pinnarin, psoralen, and xanthotoxin several times. ..
  5. Pollio A, De Natale A, Appetiti E, Aliotta G, Touwaide A. Continuity and change in the Mediterranean medical tradition: Ruta spp. (rutaceae) in Hippocratic medicine and present practices. J Ethnopharmacol. 2008;116:469-82 pubmed publisher
    b>Ruta is a genus of Rutaceae family. It features mainly shrubby plants, native to the Mediterranean region and present in traditional medicine of this region since Antiquity. The three most diffused species Ruta chalepensis L...
  6. Ekiert H, Szewczyk A, Kus A. Free phenolic acids in Ruta graveolens L. in vitro culture. Pharmazie. 2009;64:694-6 pubmed
    Eight phenolic acids were determined using HPLC method in methanolic extracts of Ruta graveolens L...
  7. De Feo V, De Simone F, Senatore F. Potential allelochemicals from the essential oil of Ruta graveolens. Phytochemistry. 2002;61:573-8 pubmed
    The essential oil of aerial parts of Ruta graveolens was obtained by hydrodistillation with a 0.74% yield on a dry weight basis. Thirty-eight components were identified by GC and GC-MS analyses...
  8. Oliva A, Meepagala K, Wedge D, Harries D, Hale A, Aliotta G, et al. Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. J Agric Food Chem. 2003;51:890-6 pubmed
    Bioassay-directed isolation of antifungal compounds from an ethyl acetate extract of Ruta graveolens leaves yielded two furanocoumarins, one quinoline alkaloid, and four quinolone alkaloids, including a novel compound, 1-methyl-2-[6'-(3' '..
  9. Pathak S, Multani A, Banerji P, Banerji P. Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Int J Oncol. 2003;23:975-82 pubmed
    ..We investigated the brain cancer cell-killing activity of a homeopathic medicine, Ruta, isolated from a plant, Ruta graveolens...

More Information

Publications110 found, 100 shown here

  1. Kuzovkina I, Al terman I, Schneider B. Specific accumulation and revised structures of acridone alkaloid glucosides in the tips of transformed roots of Ruta graveolens. Phytochemistry. 2004;65:1095-100 pubmed
    The root tips of Ruta graveolens (common rue) show strong autofluorescence of acridone alkaloids, which are characteristic secondary metabolites of this plant...
  2. Hale A, Meepagala K, Oliva A, Aliotta G, Duke S. Phytotoxins from the leaves of Ruta graveolens. J Agric Food Chem. 2004;52:3345-9 pubmed
    Bioassay-guided fractionation of the ethyl acetate extract of Ruta graveolens (common rue) leaves led to the isolation of the furanocoumarins 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and the quinolone alkaloid graveoline as ..
  3. Ivanova A, Mikhova B, Najdenski H, Tsvetkova I, Kostova I. Antimicrobial and cytotoxic activity of Ruta graveolens. Fitoterapia. 2005;76:344-7 pubmed
    The methanol, petroleum ether, ethyl acetate and water-methanol extracts of Ruta graveolens were found to possess antimicrobial and cytotoxic activities.
  4. Khouri N, El Akawi Z. Antiandrogenic activity of Ruta graveolens L in male Albino rats with emphasis on sexual and aggressive behavior. Neuro Endocrinol Lett. 2005;26:823-9 pubmed
    The Ruta graveolens L. is currently used by the Jordanian population systemically for its antispasmodic, diuretic, sedative, and analgesic effects and externally for its antirheumatic effect.
  5. Réthy B, Zupko I, Minorics R, Hohmann J, Ocsovszki I, Falkay G. Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens. Planta Med. 2007;73:41-8 pubmed
    The cytotoxic effects of a series of furanoacridones isolated from Ruta graveolens L...
  6. Rollinger J, Schuster D, Danzl B, Schwaiger S, Markt P, Schmidtke M, et al. In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta Med. 2009;75:195-204 pubmed publisher
    ..potential targets for 16 secondary metabolites isolated and identified from the aerial parts of the medicinal plant RUTA GRAVEOLENS L...
  7. Fadlalla K, WATSON A, Yehualaeshet T, Turner T, Samuel T. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res. 2011;31:233-41 pubmed
    b>Ruta graveolens is a medicinal herb that has been used for centuries against various ailments. This study examined the anticancer properties of the herb using cancer cell lines.
  8. Vialart G, Hehn A, Olry A, Ito K, Krieger C, Larbat R, et al. A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants. Plant J. 2012;70:460-70 pubmed publisher
    ..approach and a cDNA library screen to identify an orthologous ORF (Genbank accession number JF799117) from Ruta graveolens L...
  9. Gutierrez Pajares J, Zúñiga L, Pino J. Ruta graveolens aqueous extract retards mouse preimplantation embryo development. Reprod Toxicol. 2003;17:667-72 pubmed
    This work was undertaken to examine possible embryotoxicity of Ruta graveolens (rue), a plant used by indigenous communities for the purposes of therapeutic and fertility regulation...
  10. de Freitas T, Augusto P, Montanari T. Effect of Ruta graveolens L. on pregnant mice. Contraception. 2005;71:74-7 pubmed
    b>Ruta graveolens L. is used in many countries, including Brazil, as an abortifacient...
  11. Gonzalez Trujano M, Carrera D, Ventura Martinez R, Cedillo Portugal E, Navarrete A. Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. J Ethnopharmacol. 2006;106:129-35 pubmed
    The effects of an ethanol extract of the aerial parts of Ruta chalepensis on the central nervous system (CNS) and LD(50) determination were studied in mice...
  12. Endler A, Martens S, Wellmann F, Matern U. Unusually divergent 4-coumarate:CoA-ligases from Ruta graveolens L. Plant Mol Biol. 2008;67:335-46 pubmed publisher
    ..The common rue, Ruta graveolens L...
  13. Ratheesh M, Shyni G, Helen A. Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats. Inflammopharmacology. 2009;17:100-5 pubmed publisher
    b>Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India...
  14. Preethi K, Nair C, Kuttan R. Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells. Asian Pac J Cancer Prev. 2008;9:763-9 pubmed
    b>Ruta graveolens belonging to family Rutaceae has long been traditionally used as a medicinal plant as well as a flavoring agent in food. However, very little data are available on the toxicity of the plant...
  15. Ratheesh M, Shyni G, Sindhu G, Helen A. Inhibitory effect of Ruta graveolens L. on oxidative damage, inflammation and aortic pathology in hypercholesteromic rats. Exp Toxicol Pathol. 2011;63:285-90 pubmed publisher
    The purpose of the study was to investigate the efficacy of methanolic extract of Ruta graveolens L. in reducing oxidative damage, inflammation and aortic pathology in hypercholesteremic rats...
  16. Gravot A, Larbat R, Hehn A, Lièvre K, Gontier E, Goergen J, et al. Cinnamic acid 4-hydroxylase mechanism-based inactivation by psoralen derivatives: cloning and characterization of a C4H from a psoralen producing plant-Ruta graveolens-exhibiting low sensitivity to psoralen inactivation. Arch Biochem Biophys. 2004;422:71-80 pubmed
    Cinnamate 4-hydroxylase (C4H, EC 1.14.13.11) complete cDNA was cloned from the leaves of Ruta graveolens, a psoralen producing plant. The recombinant enzyme (classified CYP73A32) was expressed in Saccharomyces cerevisiae...
  17. Meepagala K, Schrader K, Wedge D, Duke S. Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs. Phytochemistry. 2005;66:2689-95 pubmed
    Bioassay-guided fractionation of the ethyl acetate extract of Ruta graveolens roots yielded rutacridone epoxide with potent selective algicidal activity towards the 2-methyl-isoborneol (MIB)-producing blue-green alga Oscillatoria ..
  18. Khori V, Nayebpour M, Semnani S, Golalipour M, Marjani A. Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts. Potential role as an anti-arrhythmic agent. Saudi Med J. 2008;29:357-63 pubmed
    To evaluate concentration-dependent effects of total extract of Ruta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.
  19. Khlifi D, Sghaier R, Amouri S, Laouini D, Hamdi M, Bouajila J. Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. Food Chem Toxicol. 2013;55:202-8 pubmed publisher
    In this study, biological activities of methanolic extracts from Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. plants, collected in Centre of Tunisia, were investigated...
  20. Ratheesh M, Sindhu G, Helen A. Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L. Inflamm Res. 2013;62:367-76 pubmed publisher
    The present study evaluates the anti-inflammatory effect of the quinoline alkaloid skimmianine (SKM), isolated from Ruta graveolens L., against carrageenan-induced acute inflammation.
  21. Barboza J, Hilje L, Durón J, Cartín V, Calvo M. [Phagodeterrence by a crude extract of common rue (Ruta chalepensis, Rutaceae) and its partitions on Hypsipyla grandella (Lepidoptera: Pyralidae) larvae]. Rev Biol Trop. 2010;58:1-14 pubmed
    ..In the search for a preventative method for managing it, the crude leaf extract of common rue (Ruta chalepensis L...
  22. Jeon J, Lee S, Lee H. Isolation of Insecticidal Constituent from Ruta graveolens and Structure-Activity Relationship Studies against Stored-Food Pests (Coleoptera). J Food Prot. 2015;78:1536-40 pubmed publisher
    Isolates from essential oil extracted from the flowers and leaves of Ruta graveolens and commercial phenolic analogs were evaluated using fumigant and contact toxicity bioassays against adults of the stored-food pests Sitophilus zeamais, ..
  23. Farzaei M, Shahpiri Z, Bahramsoltani R, Nia M, Najafi F, Rahimi R. Efficacy and Tolerability of Phytomedicines in Multiple Sclerosis Patients: A Review. CNS Drugs. 2017;31:867-889 pubmed publisher
    ..Different medicinal plants have positive effects on MS, including Andrographis paniculata, Boswellia papyrifera, Ruta graveolens, Vaccinium spp...
  24. Richardson J, Aminudin N, Abd Malek S. Chalepin: A Compound from Ruta angustifolia L. Pers Exhibits Cell Cycle Arrest at S phase, Suppresses Nuclear Factor-Kappa B (NF-?B) Pathway, Signal Transducer and Activation of Transcription 3 (STAT3) Phosphorylation and Extrinsic Apoptotic Pathway . Pharmacogn Mag. 2017;13:S489-S498 pubmed publisher
    ..i>Ruta angustifolia L...
  25. Chaftar N, Girardot M, Labanowski J, Ghrairi T, Hani K, Frère J, et al. Comparative evaluation of the antimicrobial activity of 19 essential oils. Adv Exp Med Biol. 2016;901:1-15 pubmed publisher
    ..Rosmarinus officinalis L., Ruta graveolens L. and Thymus vulgaris L., whereas others were commercial products (EOcom). Overall, T...
  26. Gentile M, Russo R, Pastorino O, Cioffi S, Barbieri F, Illingworth E, et al. Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via MEK-ERK1/2 pathway. Exp Cell Res. 2018;364:50-58 pubmed publisher
    ..Among these, ERK1/2 signaling mediates VEGF-dependent signaling pathway. Here we report that the water extract of Ruta graveolens (RGWE), widely known as a medicinal plant, is able to impair in a dose-dependent manner, cell network ..
  27. Remya V, Kuttan G. Homeopathic remedies with antineoplastic properties have immunomodulatory effects in experimental animals. Homeopathy. 2015;104:211-9 pubmed publisher
    Our previous work suggests that Thuja occidentalis, Carcinosinum and Ruta graveolens have antineoplastic properties. The mechanism of this action has not previously been studied...
  28. Ueng Y, Chen C, Huang Y, Lee I, Yun C, Chen Y, et al. Effects of aqueous extract of Ruta graveolens and its ingredients on cytochrome P450, uridine diphosphate (UDP)-glucuronosyltransferase, and reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-quinone oxidoreductase in mice. J Food Drug Anal. 2015;23:516-528 pubmed publisher
    b>Ruta graveolens (the common rue) has been used for various therapeutic purposes, including relief of rheumatism and treatment of circulatory disorder...
  29. Tarique M, Siddiqui H, Khushtar M, Rahman M. Protective effect of hydro-alcoholic extract of Ruta graveolens Linn. leaves on indomethacin and pylorus ligation-induced gastric ulcer in rats. J Ayurveda Integr Med. 2016;7:38-43 pubmed publisher
    ..The present study was designed to investigate the protective effect of hydro-alcoholic extract of Ruta graveolens (RGE) Linn. leaves on indomethacin (IND) and pylorus ligation-induced gastric ulcer in Wistar rats...
  30. Arora S, Tandon S. DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by Ruta graveolens in human colon cancer cells. Homeopathy. 2015;104:36-47 pubmed publisher
    In the present study, we investigated the anti-cancer effect of various potencies of Ruta graveolens (Ruta) on COLO-205 cell line, as evidenced by cytotoxicity, migration, clonogenecity, morphological and biochemical changes and ..
  31. Ghosh S, Sikdar S, Mukherjee A, Khuda Bukhsh A. Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo. J Integr Med. 2015;13:34-44 pubmed publisher
    ..In this study, efficacy of ethanolic extract of Ruta graveolens (RG) on skin melanoma cells (A375) in vitro and on 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin ..
  32. Mekonen T, Giday M, Kelbessa E. Ethnobotanical study of homegarden plants in Sebeta-Awas District of the Oromia Region of Ethiopia to assess use, species diversity and management practices. J Ethnobiol Ethnomed. 2015;11:64 pubmed publisher
    ..The cash crops Catha edulis, Rhamnus prinoides and Ruta chalepensis were the most frequently encountered homegarden plants...
  33. Adak S, Begley T. Flavin-N5-oxide: A new, catalytic motif in flavoenzymology. Arch Biochem Biophys. 2017;632:4-10 pubmed publisher
    ..is a recently discovered intermediate used by EncM (1,3-diketone oxidation), DszA (sulfone monooxygenase) and RutA (amide monooxygenase)...
  34. Rabaev E, Zeller L, Biton A, Barski L. [Toxic hepatitis due to the use of Ruta herbal medicine]. Harefuah. 2011;150:235-6, 305 pubmed
    ..In this case report, we present an example of toxic hepatitis due to use of Ruta herbal medicine, an unfamiliar side effect of the common herbal medicine Ruta.
  35. Karp J, Sanchez C, Guilbert P, Mina W, Demonceaux A, Curé H. Treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may reduce joint pain and stiffness linked to aromatase inhibitors in women with early breast cancer: results of a pilot observational study. Homeopathy. 2016;105:299-308 pubmed publisher
    To determine the possible effect of two homeopathic medicines, Ruta graveolens 5CH and Rhus toxicodendron 9CH, in the prevention of aromatase inhibitor (AI) associated joint pain and/or stiffness in women with early, hormone-receptor ..
  36. Kikalishvili B, Gorgaslidze N, Sulakvelidze T, Malania M, Urushadze N, Turabelidze D. [STUDY OF SOME PLANT SEED LIPIDS GROWING IN GEORGIA]. Georgian Med News. 2017;:133-137 pubmed
    The purpose of the research was to study seed lipids of cultivated plants: Medicago sativa, Ruta graveolens L., Linum usitatissimum L., which are growing on experimental field of I. Kutateladze Institute of Pharmacochemistry...
  37. Ratheesh M, Helen A. Oral administration of alkaloid fraction from Ruta graveolens inhibits oxidative stress and inflammation in hypercholesterolemic rabbits. Pharm Biol. 2013;51:1552-8 pubmed publisher
    The anti-atherogenic effect of alkaloid fraction from Ruta graveolens Linn (Rutaceae) extract is suspected to be related to its activities of antioxidation and anti-inflammation...
  38. Abramson C, Aldana E, Sulbaran Romero E, Lizano E. Fifth instar experience reduces aversiveness of the plant extract ruda (Ruta Graveolens) in the adult triatomine Rhodnius prolixus Stal 1859. J Vector Ecol. 2006;31:196-7 pubmed
  39. Sollai G, Biolchini M, Solari P, Crnjar R. Chemosensory basis of larval performance of Papilio hospiton on different host plants. J Insect Physiol. 2017;99:47-57 pubmed publisher
    ..various Apiaceae and Rutaceae as host plants, such as Ferula communis, Ferula arrigonii, Peucedanum paniculatum, Ruta lamarmorae and Pastinaca latifolia...
  40. Ouerghemmi I, Bettaieb Rebey I, Rahali F, Bourgou S, Pistelli L, Ksouri R, et al. Antioxidant and antimicrobial phenolic compounds from extracts of cultivated and wild-grown Tunisian Ruta chalepensis. J Food Drug Anal. 2017;25:350-359 pubmed publisher
    The antioxidant and antibacterial activities of phenolic compounds from cultivated and wild Tunisian Ruta chalepensis L. leaves, stems, and flowers were assessed...
  41. Held D, Gonsiska P, Potter D. Evaluating companion planting and non-host masking odors for protecting roses from the Japanese beetle (Coleoptera: Scarabaeidae). J Econ Entomol. 2003;96:81-7 pubmed
    ..Three reputedly effective companion species, rue (Ruta graveolens L.), zonal geranium (Pelargonium x hortorum Bailey), and garlic chives (Allium scheonparum L...
  42. Bennaoum Z, Benhassaini H, Falconieri D, Piras A, Porcedda S. Chemical variability in essential oils from Ruta species among seasons, and its taxonomic and ecological significance. Nat Prod Res. 2017;31:2329-2334 pubmed publisher
    Leaf essential oils of 11 samples from Ruta montana, Ruta chalepensis subsp. latifolia and Ruta chalepensis subsp...
  43. Kumar K, Sunila E, Kuttan G, Preethi K, Venugopal C, Kuttan R. Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine. Asian Pac J Cancer Prev. 2007;8:98-102 pubmed
    ..We have used Ruta, Hydrastis, Lycopodium and Thuja, which are commonly employed in homeopathy for treating cancer...
  44. Pacifico S, Piccolella S, Galasso S, Fiorentino A, Kretschmer N, Pan S, et al. Influence of harvest season on chemical composition and bioactivity of wild rue plant hydroalcoholic extracts. Food Chem Toxicol. 2016;90:102-11 pubmed publisher
    The rue (Ruta graveolens) copiousness in rural areas of the Campania Region based a thorough chemical and biological investigation aimed at exploring the seasonal variability of phenol constituents in rue leaves and its influence on their ..
  45. Lin Y, Wang Q, Gu Q, Zhang H, Jiang C, Hu J, et al. Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication. J Nat Prod. 2017;80:53-60 pubmed publisher
    ..0 μM. (-)-Chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of Ruta graveolens and used as a precursor of (-)-rutamarin...
  46. Watts C, Cooper S, Saint K. Review of Australian <i>Scirtes</i> Illiger, Ora Clark and <i>Exochomoscirtes</i> Pic Coleoptera: Scirtidae) including descriptions of new species, new groups and a multi-gene molecular phylogeny of Australian and non-Australi. Zootaxa. 2017;4347:511-532 pubmed publisher
    ..zwicki and S. serratus spp. nov. Scirtes nehouensis Ruta & Yoshitomi 2010 is synonymised with S. emmaae Watts 2004. Scirtes pygmaeus Watts, 2004 is synonymised with S...
  47. Back T, Parvez M, Wulff J. Conjugate additions of o-iodoanilines and methyl anthranilates to acetylenic sulfones. A new route to quinolones including first syntheses of two alkaloids from the medicinal herb Ruta chalepensis. J Org Chem. 2003;68:2223-33 pubmed
    ..The resulting 2-substituted 4-quinolones included the naturally occurring medicinal compounds 1 and 2 and the O-methyl derivative 3. ..
  48. Thring T, Weitz F. Medicinal plant use in the Bredasdorp/Elim region of the Southern Overberg in the Western Cape Province of South Africa. J Ethnopharmacol. 2006;103:261-75 pubmed
    ..A more structured questionnaire was used to determine which plants were most popular for particular ailments. It was found that Artemisia afra and Ruta graveolens were the most popular.
  49. Eickhorst K, Deleo V, Csaposs J. Rue the herb: Ruta graveolens--associated phytophototoxicity. Dermatitis. 2007;18:52-5 pubmed
    We describe an unusual case of phytophototoxicity induced by an herbal plant, Ruta graveolens, from the Rutaceae family. This common herb, also called rue, can be found throughout rural settings in the United States...
  50. Barboza J, Hilje L, Durón J, Cartín V, Calvo M. [Phagodeterrent and systemic activity of a fomulation derived from an extract of common rue (Ruta chalepensis, Rutaceae) on Hypsipyla grandella (Lepidoptera: Pyralidae) larvae]. Rev Biol Trop. 2010;58:15-29 pubmed
    ..Since crude extracts of common rue foliage (Ruta chalepensis L.) have phagodeterrent activity on H...
  51. Adak S, Begley T. RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide. Biochemistry. 2017;56:3708-3709 pubmed publisher
    b>RutA is a novel flavoenzyme on the uracil catabolic pathway that catalyzes uracil ring opening by a unique amide oxidation reaction. Here we provide evidence that this reaction also involves the formation of a flavin-N5-oxide.
  52. Hamdiken M, Bouhalit S, Kechrid Z. Effect of Ruta chalepensis on Zinc, Lipid Profile and Antioxidant Levels in the Blood and Tissue of Streptozotocin-Induced Diabetes in Rats Fed Zinc-Deficient Diets. Can J Diabetes. 2018;42:356-364 pubmed publisher
    ..Zinc deficiency generally induces oxidative stress, but it is well known that the antioxidant Ruta chalepensis has an effective modulator role in oxidative stress in metabolic diseases...
  53. Bernardo L, de Oliveira M, da Silva C, Dantas F, de Matros J, Caldeira de Araujo A, et al. Biological effects of rutin on the survival of Escherichia coli AB1157 and on the electrophoretic mobility of plasmid PUC 9.1 DNA. Cell Mol Biol (Noisy-le-grand). 2002;48:517-20 pubmed
    The use of natural products as medicines is growing in the world. The rutin, a compound isolated from Ruta graveolens, is a flavonoid, which has been suggested to have antioxidant properties and to reduce the triacylglycerol levels...
  54. Ivanova A, Kostova I, Rodriguez Navas H, Villegas J. Volatile components of some Rutaceae species. Z Naturforsch C. 2004;59:169-73 pubmed
    The volatile components of the aerial parts of Ruta graveolens and Haplophyllum suaveolens, as well as of leaves of Zanthoxylum limoncello, Z. panamense and Z. setulosum have been studied by GC/MS analysis.
  55. Furniss D, Adams T. Herb of grace: an unusual cause of phytophotodermatitis mimicking burn injury. J Burn Care Res. 2007;28:767-9 pubmed
    ..of a 2-year-old child who suffered an acute phytophotodermatitis with systemic upset after contact with the herb Ruta Graveolens (common rue, Herb of Grace)...
  56. Orlita A, Sidwa Gorycka M, Malinski E, Czerwicka M, Kumirska J, Golebiowski M, et al. Effective biotic elicitation of Ruta graveolens L. shoot cultures by lysates from Pectobacterium atrosepticum and Bacillus sp. Biotechnol Lett. 2008;30:541-5 pubmed
    Growth of Ruta graveolens shoots was induced when Bacillus sp. cell lysates were added to the culture medium...
  57. Acquaviva R, Iauk L, Sorrenti V, Lanteri R, Santangelo R, Licata A, et al. Oxidative profile in patients with colon cancer: effects of Ruta chalepensis L. Eur Rev Med Pharmacol Sci. 2011;15:181-91 pubmed
    ..the involvement of free radicals in tumor progression and to investigate the effects of an ethanolic extract of Ruta Chalepensis L. and of rutin in blood of patients with colon cancer. Leaves of Ruta Chalepensis L...
  58. Harat Z, Sadeghi M, Sadeghipour H, Kamalinejad M, Eshraghian M. Immobilization effect of Ruta graveolens L. on human sperm: a new hope for male contraception. J Ethnopharmacol. 2008;115:36-41 pubmed
    ..In this study, the contraceptive effects of Ruta graveolens L...
  59. Al Qurainy F, Khan S, Tarroum M, Al Hemaid F, Ali M. Molecular authentication of the medicinal herb Ruta graveolens (Rutaceae) and an adulterant using nuclear and chloroplast DNA markers. Genet Mol Res. 2011;10:2806-16 pubmed publisher
    ..b>Ruta graveolens, sold as a dried medicinal herb, can be adulterated with Euphorbia dracunculoides...
  60. van Huyssteen M, Milne P, Campbell E, van de Venter M. Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. Afr J Tradit Complement Altern Med. 2011;8:150-8 pubmed
    ..project with these practitioners focused on the screening of Bulbine frutescens, Ornithogalum longibracteatum, Ruta graveolens, Tarchonanthus camphoratus and Tulbaghia violacea for antidiabetic and cytotoxic potential...
  61. Diwan R, Malpathak N. Bioprocess optimization of furanocoumarin elicitation by medium renewal and re-elicitation: a perfusion-based approach. Appl Biochem Biotechnol. 2011;163:756-64 pubmed publisher
    ..niger) elicitors on furanocoumarin production and in situ product removal was studied using shoot cultures of Ruta graveolens L. Elicitation by yeast extract (1% w/v) on day 15 was most effective. It led to 7...
  62. Manzali de Sá I, Elisabetsky E. Medical knowledge exchanges between Brazil and Portugal: an ethnopharmacological perspective. J Ethnopharmacol. 2012;142:762-8 pubmed publisher
    ..This "Brazilian folk medicine" is usually described as a rich mixture of African, European, and Indigenous medical traditions...
  63. Schelz Z, Ocsovszki I, Bózsity N, Hohmann J, Zupko I. Antiproliferative Effects of Various Furanoacridones Isolated from Ruta graveolens on Human Breast Cancer Cell Lines. Anticancer Res. 2016;36:2751-8 pubmed
    Thanks to its biologically active constituents, Ruta graveolens L. (Rutaceae) is a widely used medicinal plant...
  64. Hadis M, Lulu M, Mekonnen Y, Asfaw T. Field trials on the repellent activity of four plant products against mainly Mansonia population in western Ethiopia. Phytother Res. 2003;17:202-5 pubmed
    The repellent activity of essential oils of lemon eucalyptus (Eucalyptus maculata citrodion), rue (Ruta chalepensis), oleoresin of pyrethrum (Chrysanthemum cinerariaefolium) and neem (Azadiracta indica) have been field tested as 40%, 50% ..
  65. Arora S, Aggarwal A, Singla P, Jyoti S, Tandon S. Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells. Homeopathy. 2013;102:274-82 pubmed publisher
    ..lines deriving from tumors of particular organs, Sarsaparilla (Sars) on ACHN cells (human renal adenocarcinoma), Ruta graveolens (Ruta) on COLO-205 (human colorectal carcinoma), and Phytolacca decandra (Phyto) on MCF-7 (human breast ..
  66. Kambouche N, Merah B, Bellahouel S, Bouayed J, Dicko A, Derdour A, et al. Chemical composition and antioxidant potential of Ruta montana L. essential oil from Algeria. J Med Food. 2008;11:593-5 pubmed publisher
    The essential oil of aerial parts of Ruta montana L. growing in the Oran region in the west of Algeria was obtained by hydrodistillation with a 1.63% yield on a dry weight basis...
  67. Jaradat N, Adwan L, K aibni S, Zaid A, Shtaya M, Shraim N, et al. Variability of Chemical Compositions and Antimicrobial and Antioxidant Activities of Ruta chalepensis Leaf Essential Oils from Three Palestinian Regions. Biomed Res Int. 2017;2017:2672689 pubmed publisher
    ..This study was performed to identify the chemical compositions of the essential oil of Ruta chalepensis growing wildly in three regions in Palestine and to assess and compare their antimicrobial and ..
  68. Preethi K, Ellanghiyil S, Kuttan G, Kuttan R. Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action. Integr Cancer Ther. 2012;11:172-82 pubmed publisher
    ..Earlier studies indicated that homoeopathic medicines are cytotoxic to tumor cells and reduced animal tumors. However, the mechanism of homoeopathic medicines at the cellular level is not known...
  69. Bertrand C, Fabre N, Moulis C. A new coumarin glucoside, coumarins and alkaloids from Ruta corsica roots. Fitoterapia. 2004;75:242-4 pubmed
    ..one coumarin, five furanocoumarins, three bicoumarins, three quinoline alkaloids and one sinapoyl sucrose derivative have been isolated from the roots of Ruta corsica.
  70. Waldstein A. Mexican migrant ethnopharmacology: pharmacopoeia, classification of medicines and explanations of efficacy. J Ethnopharmacol. 2006;108:299-310 pubmed
    ..Asteraceae], Mentha spp. L. [Lamiaceae], Ruta spp. L. [Rutaceae], Ocimum basilicum L...
  71. Orlita A, Sidwa Gorycka M, Paszkiewicz M, Malinski E, Kumirska J, Siedlecka E, et al. Application of chitin and chitosan as elicitors of coumarins and fluoroquinolone alkaloids in Ruta graveolens L. (common rue). Biotechnol Appl Biochem. 2008;51:91-6 pubmed publisher
    Common rue (Ruta graveolens L.) accumulates various types of secondary metabolites, such as coumarins furanocoumarins, acridone and quinolone alkaloids and flavonoids...
  72. Bodendiek S, Mahieux C, Hänsel W, Wulff H. 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3. Eur J Med Chem. 2009;44:1838-52 pubmed publisher
    ..Using 5-methoxypsoralen (5-MOP, 1), a compound isolated from Ruta graveolens, as a template we previously synthesized 5-(4-phenoxybutoxy)psoralen (PAP-1, 2) which inhibits Kv1...
  73. Ratheesh M, Shyni G, Sindhu G, Helen A. Protective effects of isolated polyphenolic and alkaloid fractions of Ruta graveolens L. on acute and chronic models of inflammation. Inflammation. 2010;33:18-24 pubmed publisher
    b>Ruta graveolens L...
  74. Moazedi A, Dabir N, Naseri M, Zadkarami M. The role of NO and cGMP in antispasmodic activity of Ruta chalepensis leaf extract on rat ileum. Pak J Biol Sci. 2010;13:83-7 pubmed
    The aim of present study was to investigate the effect of hydroalcoholic extract of Ruta chalepensis (Rutaceae) leaves on rat ileum contractility and possible mechanism(s) involved...
  75. Lo W, Lim Y, Chen C, Hsu C, Soucek P, Yun C, et al. A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation. Arch Toxicol. 2012;86:1927-38 pubmed publisher
    ..These findings revealed that suicidal inhibition of Cyp2a5 and the CAR-mediated Cyp2b9/10 induction concurrently occurred in chalepensin-treated mice...
  76. Faria J, Barbosa P, Bennett R, Mota M, Figueiredo A. Bioactivity against Bursaphelenchus xylophilus: Nematotoxics from essential oils, essential oils fractions and decoction waters. Phytochemistry. 2013;94:220-8 pubmed publisher
    ..Twenty EOs showed corrected mortalities ?96% at 2 ?L/mL. These were further tested at lower concentrations. Ruta graveolens, Satureja montana and Thymbra capitata EOs showed lethal concentrations (LC100)<0.4?L/mL...
  77. Abu Mraheil M, Heisig A, Heisig P. An improved assay for the detection of alterations in bacterial DNA supercoiling in vivo. Pharmazie. 2013;68:541-8 pubmed
  78. Richardson J, Sethi G, Lee G, Malek S. Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells. BMC Complement Altern Med. 2016;16:389 pubmed
    Cancer has been one of the leading causes of mortality in this era. Ruta angustifolia L. Pers has been traditionally used as an abortifacient, antihelmintic, emmenagogue and ophthalmic...
  79. Iauk L, Mangano K, Rapisarda A, Ragusa S, Maiolino L, Musumeci R, et al. Protection against murine endotoxemia by treatment with Ruta chalepensis L., a plant with anti-inflammatory properties. J Ethnopharmacol. 2004;90:267-72 pubmed
    The anti-inflammatory effect of the extract of Ruta Chalepensis L. (Rutaceae) on the course of lethal endotoxemia in BALB/c mice was studied. When administered by gavage as 1 g/kg per day starting 14 or 7 days prior to injection of 0...
  80. Escher S, Niclass Y, van de Waal M, Starkenmann C. Combinatorial synthesis by nature: volatile organic sulfur-containing constituents of Ruta chalepensis L. Chem Biodivers. 2006;3:943-57 pubmed
    ..new natural fragrance and flavor ingredients prompted us to examine a solvent extract of sulfurous-sweaty smelling Ruta chalepensis L. (Rutaceae) plant material more closely...
  81. Es S, Kuttan G, Kc P, Kuttan R. Effect of homeopathic medicines on transplanted tumors in mice. Asian Pac J Cancer Prev. 2007;8:390-4 pubmed
    ..It was found that Ruta graveolens 200c and Hydrastis canadensis 200c significantly increased the lifespan of Ehrlich Ascites Carcinoma and ..
  82. Diwan R, Malpathak N. Novel technique for scaling up of micropropagated Ruta graveolens shoots using liquid culture systems: a step towards commercialization. N Biotechnol. 2008;25:85-91 pubmed publisher
    Wide applications of Ruta graveolens L. in pharmaceutical industry has led to increased interest in large-scale plant production, with emphasis on use of in vitro cultures...
  83. Karamat F, Olry A, Doerper S, Vialart G, Ullmann P, Werck Reichhart D, et al. CYP98A22, a phenolic ester 3'-hydroxylase specialized in the synthesis of chlorogenic acid, as a new tool for enhancing the furanocoumarin concentration in Ruta graveolens. BMC Plant Biol. 2012;12:152 pubmed publisher
    ..with proven therapeutic properties and are produced in only a small number of medicinal plant species such as Ruta graveolens. In vivo, these molecules play a protective role against phytophageous insect attack...
  84. Conti B, Leonardi M, Pistelli L, Profeti R, Ouerghemmi I, Benelli G. Larvicidal and repellent activity of essential oils from wild and cultivated Ruta chalepensis L. (Rutaceae) against Aedes albopictus Skuse (Diptera: Culicidae), an arbovirus vector. Parasitol Res. 2013;112:991-9 pubmed publisher
    ..In our research, the essential oils extracted from fresh leaves of wild and cultivated plants of Ruta chalepensis L...
  85. el Agraa S, el Badwi S, Adam S. Preliminary observations on experimental Ruta graveolens toxicosis in Nubian goats. Trop Anim Health Prod. 2002;34:271-81 pubmed
    We present the first reported study of Ruta graveolens toxicity in 7-8-month-old Nubian goats. Oral administration of 5 g/kg bw per day of R...
  86. Ekiert H, Abou Mandour A, Czygan F. Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture. Pharmazie. 2005;60:66-8 pubmed
    ..dynamics of accumulation of five linear furanocoumarins and umbelliferone in stationary liquid cultures of Ruta graveolens ssp. divaricata (Tenore) Gams during 6-week growth cycles...
  87. Günaydin K, Savci S. Phytochemical studies on Ruta chalepensis (Lam.) Lamarck. Nat Prod Res. 2005;19:203-10 pubmed
    b>Ruta chalepensis is a rich source of important secondary metabolites such as furanocoumarins and alkaloids. Besides, it is a medicinal plant and still used in traditional medicine...
  88. Burga L, Wellmann F, Lukacin R, Witte S, Schwab W, Schröder J, et al. Unusual pseudosubstrate specificity of a novel 3,5-dimethoxyphenol O-methyltransferase cloned from Ruta graveolens L. Arch Biochem Biophys. 2005;440:54-64 pubmed
    A cDNA was cloned from Ruta graveolens cells encoding a novel O-methyltransferase (OMT) with high similarity to orcinol or chavicol/eugenol OMTs, but containing a serine-rich N-terminus and a 13 amino acid insertion between motifs IV and ..
  89. Lièvre K, Tran T, Doerper S, Hehn A, Lacoste P, Thomasset B, et al. Agrobacterium-mediated transformation of Ruta graveolens L. Methods Mol Biol. 2009;547:235-48 pubmed publisher
    Agrobacterium tumefaciens is used to develop a genetic transformation method for a medicinal plant Ruta graveolens. The direct plant regeneration strategy is preferred to callus line establishment...
  90. Grigorjev C, Brizuela N. [Effects of ruta SSP on the activity of the smooth gastrointestinal muscle isolated of rat]. Rev Fac Cien Med Univ Nac Cordoba. 2010;67:77-80 pubmed
    b>Ruta graveolens L. and Ruta chalepensis L. are plants used in folkloric medicine as antispasmodics, digestive and for intestinal gases...
  91. Diwan R, Malpathak N. Effect of polyamines on shoot multiplication and furanocoumarin production in Ruta graveolens cultures. Nat Prod Commun. 2012;7:895-8 pubmed
    ..furanocoumarin production was investigated by exogenous addition, at different concentrations, to shoot cultures of Ruta graveolens at different phases of growth...
  92. Haddouchi F, Chaouche T, Zaouali Y, Ksouri R, Attou A, Benmansour A. Chemical composition and antimicrobial activity of the essential oils from four Ruta species growing in Algeria. Food Chem. 2013;141:253-8 pubmed publisher
    ..of this research is to study the antibacterial and antifungal effects of four traditional plants essential oils, Ruta angustifolia, Ruta chalepensis, Ruta graveolens and Ruta tuberculata, against standard bacterial and fungal strains...