Summary: A plant genus of the family RUTACEAE. Members contain BERBERINE, indolopyridoquinazoline and other ALKALOIDS and limonoids.

Top Publications

  1. Park E, Rhee H, Jung H, Ju S, Lee Y, Lee S, et al. Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytother Res. 2007;21:746-50 pubmed develop an antiinflammatory herbal remedy that is as potent as current synthetic medicines, the cortex of Phellodendron amurense Rupr (Rutaceae) and the rhizomes of Coptis chinensis Franch (Ranunculaceae) were combined in a 2:1 ..
  2. Garrison R, Chambliss W. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006;12:50-4 pubmed
    ..the efficacy of a dietary supplement ingredient containing proprietary extracts of Magnolia officinalis and Phellodendron amurense in helping overweight, otherwise healthy, premenopausal female adults, who typically eat more in ..
  3. Kim H, Shin H, Park H, Kim Y, Yun Y, Park S, et al. In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex. J Clin Virol. 2008;41:122-8 pubmed
    ..A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of severe acute respiratory syndrome (SARS)...
  4. Oben J, Enonchong E, Kothari S, Chambliss W, Garrison R, Dolnick D. Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study. Nutr J. 2008;7:16 pubmed publisher
    ..The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee...
  5. Oben J, Enonchong E, Kothari S, Chambliss W, Garrison R, Dolnick D. Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. Nutr J. 2009;8:38 pubmed publisher
    ..The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on joint health in overweight and normal weight adults diagnosed with osteoarthritis...
  6. Steinmann D, Baumgartner R, Heiss E, Bartenstein S, Atanasov A, Dirsch V, et al. Bioguided isolation of (9Z)-octadec-9-enoic acid from Phellodendron amurense Rupr. and identification of fatty acids as PTP1B inhibitors. Planta Med. 2012;78:219-24 pubmed publisher
    ..PTP1B, (9 Z)-octadec-9-enoic acid (oleic acid) could be identified as a major PTP1B inhibitor in the bark of Phellodendron amurENSE Rupr. (Rutaceae); it showed an IC?? value of 6.2?µM...
  7. Garcia G, Nicole A, Bhaskaran S, Gupta A, Kyprianou N, Kumar A. Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. Neoplasia. 2006;8:523-33 pubmed
    ..Nexrutine is a herbal extract developed from Phellodendron amurense...
  8. Min Y, Kwon H, Yang M, Lee K, Choi S, Lee K. Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity. Arch Pharm Res. 2007;30:58-63 pubmed
    Three limonoids and five alkaloids were isolated from the chloroform layer of the MeOH extract of the bark of Phellodendron amurense (Rutaceae)...
  9. Kalman D, Feldman S, Feldman R, Schwartz H, Krieger D, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008;7:11 pubmed publisher
    ..This study measured the effects of a proprietary blend of extracts of Magnolia officinalis and Phellodendron amurense (Relora) on anxiety, stress and sleep in healthy premenopausal women.

More Information

Publications118 found, 100 shown here

  1. Wang W, Zu Y, Fu Y, Reichling J, Suschke U, Nokemper S, et al. In vitro antioxidant, antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr. from China. Am J Chin Med. 2009;37:195-203 pubmed
    b>Phellodendron amurense Rupr. bark extracts were examined for antioxidant activity, antimicrobial activity and antiviral activity on herpes simplex virus type 1 (HSV-1)...
  2. Xu Y, Ventura S. Extracts of bark from the traditional Chinese herb Phellodendron amurense inhibit contractility of the isolated rat prostate gland. J Ethnopharmacol. 2010;127:196-9 pubmed publisher
    To assess the effectiveness of the traditional Chinese herb Phellodendron amurense in treating urological disorders.
  3. James M, Fu H, Liu Y, Chen D, You M. Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. Mol Carcinog. 2011;50:1-7 pubmed publisher
    b>Phellodendron amurense extract is a Chinese herbal remedy that has recently been studied for its antitumor, antimicrobial and other biological activities...
  4. Kim J, Huh J, Baek Y, Lee J, Choi D, Park D. Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes. J Ethnopharmacol. 2011;134:234-42 pubmed publisher
    Traditional medicine has been widely using Phellodendron amurense Rupr. (Rutaceae) to treat various inflammatory diseases including arthritis.
  5. Yan H, Sun X, Sun S, Wang S, Zhang J, Wang R, et al. Anti-ultraviolet radiation effects of Coptis chinensis and Phellodendron amurense glycans by immunomodulating and inhibiting oxidative injury. Int J Biol Macromol. 2011;48:720-5 pubmed publisher
    ..The monosaccharide constituents of Phellodendron amurense glycan were determined by HPLC analysis. HPLC analysis proved that P...
  6. Riu M, Mestres M, Busto O, Guasch J. Quantification of chloroanisoles in cork using headspace solid-phase microextraction and gas chromatography with electron capture detection. J Chromatogr A. 2006;1107:240-7 pubmed
    ..6 ng/g), 2,3,4,5,6-pentachloroanisole (0.8 ng/g). The other quality parameters are: recoveries (90.3-105.8%), repeatability (4-13% (RSD expressed)) and intermediate precision (5-14% (RSD expressed)). ..
  7. Wu Y, Wang Y, Gu X, Zhang L, Yan C. [Development of two-dimensional micro strong cation exchange liquid chromatography/reversed phase pressurized capillary electrochromatography and its application on Cortex Phellodendri extract]. Se Pu. 2010;28:226-30 pubmed
    ..Compared with one-dimensional liquid chromatography, it has higher resolution and larger peak capacity. The two-dimensional chromatographic system is suitable for the separation and analysis of complex samples. ..
  8. Zarmouh N, Messeha S, Elshami F, Soliman K. Natural Products Screening for the Identification of Selective Monoamine Oxidase-B Inhibitors. European J Med Plants. 2016;15: pubmed
    ..The top extracts with the most potent RIBs were Psoralea corylifolia seeds, Phellodendron amurense bark, Glycyrrhiza uralensis roots, and Ferula assafoetida roots, with the highest ..
  9. Zhang Q, Cai L, Zhong G, Luo W. [Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2010;35:2061-4 pubmed
    ..94%, 101.17%, 96.22% and 98.90%, respectively. The method is simple, accurate and repeatable, and can be used in content determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex. ..
  10. Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher
    Cortex Phellodendri (C. Phellodendri), the dried trunk bark of Phellodendron amurense Ruprecht, has been known as a traditional herbal medicine, showing several bioactivities. However, antiviral activity of C...
  11. Xu G, Zhang Y, Ding Q. Efficacy of Prostant on chronic prostatitis in 119 patients. Acta Pharmacol Sin. 2003;24:615-8 pubmed
    ..05). Only 2 cases (1.7 %) reported serious diarrhea. The Prostant is effective and safe in the treatment of chronic prostatitis, especially on those cases whose symptom and inflammation in prostatic fluid are not too serious. ..
  12. Kido K, Sato K, Makanae Y, Ato S, Hayashi T, Fujita S. Herbal supplement Kamishimotsuto augments resistance exercise-induced mTORC1 signaling in rat skeletal muscle. Nutrition. 2016;32:108-13 pubmed publisher
    Kamishimotsuto (KST) is a supplement containing 13 different herbs including Phellodendron bark, Anemarrhena rhizome and ginseng that have been shown to activate mammalian target of rapamycin complex 1 (mTORC1) and thereby increase ..
  13. Tang X, Liang M, Li X, Xiong W, Tang H, Jiang X, et al. [Determination of two mouldy compounds in cork by gas chromatography-mass spectrometry]. Se Pu. 2012;30:733-7 pubmed
    ..The method is suitable to the determination of TCA and TBA in corks. ..
  14. Yuan L, Wu P, Xia T, Chen X. [Preparative separation of alkaloids from Cortex Phellodendri by high speed countercurrent chromatography]. Se Pu. 2002;20:185-6 pubmed
    ..5 mol/L HCl (2:1:1, volume ratio). Some alkaloid components were obtained, and identification of berberine was made by thin-layer chromatography. ..
  15. Yang Q, Zhang F, Gao S, Sun L, Chen W. Determination of bioactive compounds in Cortex Phellodendri by high-performance liquid chromatography. J AOAC Int. 2010;93:855-61 pubmed
  16. Yan D, Xiao X. [Investigation on pattern and methods of quality control for Chinese materia medica based on dao-di herbs and bioassay - bioassay for Coptis chinensis]. Yao Xue Xue Bao. 2011;46:568-72 pubmed
    ..The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the dao-di herbs and bioassay...
  17. Pizarro C, Perez del Notario N, González Sáiz J. Optimisation of a microwave-assisted extraction method for the simultaneous determination of haloanisoles and halophenols in cork stoppers. J Chromatogr A. 2007;1149:138-44 pubmed
    ..The new method was also satisfactorily applied to real cork stopper samples. ..
  18. Kim Y, Lim H, Kim Y, Lee J, Kim B, Jeong S. Phytochemical Quantification and the In Vitro Acetylcholinesterase Inhibitory Activity of Phellodendron chinense and Its Components. Molecules. 2017;22: pubmed publisher
    The dried bark of Phellodendron chinense has been used as a traditional herbal medicine to remove damp heat, relieve consumptive fever, and cure dysentery and diarrhea...
  19. Carasek E, Cudjoe E, Pawliszyn J. Fast and sensitive method to determine chloroanisoles in cork using an internally cooled solid-phase microextraction fiber. J Chromatogr A. 2007;1138:10-7 pubmed
    ..8 and 1.6 ng g(-1) of cork, while for HS-SPME were between 4 and 6 ng g(-1) of cork. Furthermore, the CF-HS-SPME procedure could be used as a non-destructive method after minor modification of the agitator for the autosampler. ..
  20. Chiu C, Li C, Chiu C, Niwa M, Kitanaka S, Damu A, et al. Constituents of leaves of Phellodendron japonicum MAXIM. and their antioxidant activity. Chem Pharm Bull (Tokyo). 2005;53:1118-21 pubmed
    ..3) and (2R)-phellodensin-F (5), together with thirty known compounds have been isolated from the leaves of Phellodendron japonicum MAXIM...
  21. Linn Y, Lu J, Lim L, Sun H, Sun J, Zhou Y, et al. Berberine-induced haemolysis revisited: safety of Rhizoma coptidis and Cortex phellodendri in chronic haematological diseases. Phytother Res. 2012;26:682-6 pubmed publisher
    ..There were, however, very few clinical reports of adverse reaction attributable to RC or CP in oral TCM concoction. We conclude that based on traditional dosage and indication, the use of RC and CP in oral concoction is safe...
  22. Xu N, Yang H, Cui M, Wan C, Liu S. High-performance liquid chromatography-electrospray ionization-mass spectrometry ligand fishing assay: a method for screening triplex DNA binders from natural plant extracts. Anal Chem. 2012;84:2562-8 pubmed publisher
    ..Two components (berberine and palmatine) in the extract of Phellodendron chinense Schneid cortexes were fished out as triplex DNA binders by this assay, which indicated its ..
  23. Kun L, Fei W, Yun Peng D, Xiao Qiu P, Yun Juan E, Huo Li Z. Simultaneous determination of contents of three active components in Jiejia tincture by HPLC method. Afr J Tradit Complement Altern Med. 2013;10:370-374 pubmed
  24. Wang L, Wang X, Zhu X, Liu Y, Du W, Ji J, et al. Gastroprotective Effect of Alkaloids from Cortex Phellodendri on Gastric Ulcers in Rats through Neurohumoral Regulation. Planta Med. 2017;83:277-284 pubmed publisher
    The present study aimed to investigate the gastroprotective activity of the total alkaloids from the bark of Phellodendron amurense and identify their possible mechanism...
  25. Park S, Lai Y, Kim C. Immunopontentiating and antitumor activities of the purified polysaccharides from Phellodendron chinese SCHNEID. Life Sci. 2004;75:2621-32 pubmed
    The polysaccharide fractions were isolated and purified from Phellodendron chinese SCHNEID, and antitumor activities were examined at dosages of 2, 5 and 10 mg/100 g...
  26. Chen M, Xian Y, Ip S, Tsai S, Yang J, Che C. Chemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis. Planta Med. 2010;76:1530-5 pubmed publisher
    The Chinese herbal drug Cortex Phellodendri is derived from two species of PHELLODENDRON, P. CHINENSIS Schneid. and P. AMURENSE Rupr...
  27. Kaufmann D, Kaur Dogra A, Tahrani A, Herrmann F, Wink M. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer's Disease Target. Molecules. 2016;21: pubmed publisher
    ..All three extracts of Berberis bealei (formerly Mahonia bealei), Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, substantially inhibited AChE...
  28. Zalacain A, Alonso G, Lorenzo C, Iniguez M, Salinas M. Stir bar sorptive extraction for the analysis of wine cork taint. J Chromatogr A. 2004;1033:173-8 pubmed
    ..21 and 205.11 pg/l; while in white wines, the LOD ranged between 5.82 and 30.50 pg/l and LOQ ranged between 19.41 and 101.61 pg/l. These concentrations were always lower than their respective olfactory thresholds values. ..
  29. Yang H, Yao W, Wang Y, Shi L, Su R, Wan D, et al. High-throughput screening of triplex DNA binders from complicated samples by 96-well pate format in conjunction with peak area-fading UHPLC-Orbitrap MS. Analyst. 2017;142:670-675 pubmed publisher
    ..The potential of the approach was examined using the extracts of Rhizoma Coptidis and Phellodendron chinense Schneid cortexe...
  30. Guedes A, Madeira L, Boaventura R, Costa C. Fenton oxidation of cork cooking wastewater--overall kinetic analysis. Water Res. 2003;37:3061-9 pubmed
    ..0 mg/L min, respectively. The experiments performed at different temperatures confirmed the global kinetic model and allowed to calculate the global activation energy for the second-order reaction (70.7 kJ/mol). ..
  31. Benitez F, Acero J, Garcia J, Leal A. Purification of cork processing wastewaters by ozone, by activated sludge, and by their two sequential applications. Water Res. 2003;37:4081-90 pubmed
    ..These enhancements were greater in the aerobic degradation-ozonation sequence than in the ozonation-aerobic degradation sequence. ..
  32. Peres J, Beltrán de Heredia J, Domínguez J. Integrated Fenton's reagent-coagulation/flocculation process for the treatment of cork processing wastewaters. J Hazard Mater. 2004;107:115-21 pubmed
    ..5 mol/l of H2O2) reduced the COD, total polyphenols and aromatic compounds of the effluent by 74, 99 and 98%, respectively, which supposes a considerable improvement compared with the first method. ..
  33. Liu Q, Shi J, Yang Y, Fang Z, Liang S, Guo R. [Effects on secretory function of rat gonad by Erxian decoction and its disassembled prescriptions]. Zhongguo Zhong Yao Za Zhi. 2005;30:1023-6 pubmed
    ..To explain functions, differences and coordination of three divided combinations of the "Erxian decoction", the famous traditional Chinese formula, on the effective sites of gonad gland at the cell level...
  34. Ghosh R, Graham H, Rivas P, Tan X, Crosby K, Bhaskaran S, et al. Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management. Anticancer Res. 2010;30:857-65 pubmed
    ..Previous studies from our laboratory show that Nexrutine (bark extract from Phellodendron amurense) prevents prostate tumor development when given prior to the development of high-grade prostatic ..
  35. Liu B, Jia X, Cao Y, Chen S, Gao P, Wang Y, et al. Changtai granule, a traditional Chinese drug, protects hapten-induced colitis by attenuating inflammatory and immune dysfunctions. J Ethnopharmacol. 2008;115:1-8 pubmed
    ..The potential anti-inflammatory and immunomodulatory effect of CT in TNBS colitis suggests that CT may be an effective treatment approach for inflammatory bowel disease...
  36. Sun J, Ma J, Jin J, Wang H, Wen Q, Zhang H, et al. [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS]. Yao Xue Xue Bao. 2006;41:380-4 pubmed
    ..While 10 from Coptis chinensis Franch and 20 from Phellodendron amurense Rupr., Peaks 3, 4, 6, 9, 11 and 12 came from them together...
  37. Lin H, Lu N, Yang J, Lin J, Lin J. [Refinement study of macroporous resin for Huang-Lian-Jie-Du decoction]. Zhong Yao Cai. 2007;30:1296-301 pubmed
    ..The ratio of diameter and high of the resin column was 1:20. The desorption solution was 90% alcohol of 4BV. YWD-09D macroporous resin and its selected condition are suitable for refinement of Huang-Lian-Jie-Du decoction. ..
  38. Appiah S, Revitt M, Jones H, Vu M, Simmonds M, Bell C. Antiinflammatory and Hepatoprotective Medicinal Herbs as Potential Substitutes for Bear Bile. Int Rev Neurobiol. 2017;135:149-180 pubmed publisher
    ..Gardenia jasminoides (zh? zi; ), Scutellaria baicalensis (huáng qín; ), Coptis chinensis (huáng lián, ), Phellodendron amurense (huáng b?i; ), Andrographis paniculata (chuan xin lian; ), and Rheum palmatum (dà huang; ), two ..
  39. Fang Q, Zhan X, Mo J, Sun M. [The effect of huanglian jiedu tang on Alzheimer's disease and its influence on cytokines]. Zhongguo Zhong Yao Za Zhi. 2004;29:575-8 pubmed
    ..To investigate the effect of huanglian jiedu tang on Alzheimer' s disease, and its influence on cytokines...
  40. Ezquerro O, Garrido López A, Tena M. Determination of 2,4,6-trichloroanisole and guaiacol in cork stoppers by pressurised fluid extraction and gas chromatography-mass spectrometry. J Chromatogr A. 2006;1102:18-24 pubmed
  41. Sun H, Li T, Sun L, Qiu Y, Huang B, Yi B, et al. Inhibitory effect of traditional Chinese medicine Zi-Shen Pill on benign prostatic hyperplasia in rats. J Ethnopharmacol. 2008;115:203-8 pubmed
    ..These results suggest that ZSPE has a definite inhibitory effect on BPH and might be an alternative medicine for treatment of human BPH...
  42. Lin P, Hsu K, Shiu M, Liu W. Phellodendron chinense Schneid: A novel yellow-emitting luminescent material for white light-emitting diodes. Sci Rep. 2017;7:9009 pubmed publisher
    ..In this study, we disclose a rare-earth free and yellow-emission phosphor, Phellodendron, which could be both excited by near ultraviolet light and blue light...
  43. Cui W, Tian J, Ma Z, Guo Y, Wang J, Li X. A new isocoumarin from bark of Pellodendron chinense. Nat Prod Res. 2003;17:427-9 pubmed
    A new isocoumarin, 3-acetyl-3,4-dihydro-5,6-dimethoxy-1H-2-benzopyran-1-one, was isolated from the cortex of Phellodendron chinense schneid. The structure was determined on the basis of spectroscopic evidences.
  44. Yan C, Wang Y, Hao X. [Water-soluble chemical constituents from fruits of Phellodendron chinense var. glabriusculum]. Zhongguo Zhong Yao Za Zhi. 2009;34:2895-7 pubmed
    To study the water-soluble chemical constituents from the fruits of Phellodendron chinense var. glabriusculum. Chemical constituents were purified by chromatographic methods and identified by spectroscopic analysis...
  45. Xian Y, Mao Q, Ip S, Lin Z, Che C. Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J Ethnopharmacol. 2011;137:1425-30 pubmed publisher
    Cortex Phellodendri is derived from the dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr...
  46. Kou X, Xu M, Gu Y. [Determination of trace heavy metal elements in cortex Phellodendron chinense by ICP-MS after microwave-assisted digestion]. Guang Pu Xue Yu Guang Pu Fen Xi. 2007;27:1197-200 pubmed
    ..plasma mass spectrometry (ICP-MS) for determination of the contents of 8 trace heavy metal elements in cortex Phellodendron chinense after microwave-assisted digestion of the sample has been developed...
  47. Zhao Y, Xu Y, Gu J, Wang Z. [Seasonal dynamics of carbon and nitrogen concentrations in Phellodendron amurense fine roots]. Ying Yong Sheng Tai Xue Bao. 2011;22:2546-52 pubmed
    Taking a 23 years old Phellodendron amurense plantation as test object, the first five order roots of P...
  48. Jiang T, Qian J, Ding J, Wang G, Ding X, Liu S, et al. Metabolomic profiles delineate the effect of Sanmiao wan on hyperuricemia in rats. Biomed Chromatogr. 2017;31: pubmed publisher
  49. Fujii A, Okuyama T, Wakame K, Okumura T, Ikeya Y, Nishizawa M. Identification of anti-inflammatory constituents in Phellodendri Cortex and Coptidis Rhizoma by monitoring the suppression of nitric oxide production. J Nat Med. 2017;71:745-756 pubmed publisher
    ..However, the differences in their medicinal properties are not well characterized. We prepared extracts from Phellodendron amurense bark (PAB) and Coptis chinensis rhizome (CCR) and separated them into alkaloid and non-alkaloid ..
  50. Sauret Valet J. [The divine cork oak]. Arch Bronconeumol. 2002;38:329-33 pubmed
  51. Kolahi J, Ghalayani P, Varshosaz J. Systemic toxicity following ingestion of the chlorhexidine gluconate solution: a case report. J Int Acad Periodontol. 2006;8:45-6 pubmed
    ..It is known that CHX is a cation, and, therefore, first aid in case of intoxication with CHX involves using anionic materials. ..
  52. Chen C, Wang C, Chen A. Recognition of molecularly imprinted polymers for a quaternary alkaloid of berberine. Talanta. 2011;84:1038-46 pubmed publisher
    ..80 ?mol/L. SPE analyses of a mixture of BER and PAL and the methanol extract from the cortices of Phellodendron wilsonii showed that AD-10 had more efficiency, and higher specificity and selectivity for SPE in the ..
  53. Ryuk J, Zheng M, Lee M, Seo C, Li Y, Lee S, et al. Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids. Arch Pharm Res. 2012;35:1045-54 pubmed publisher
    Phellodendri Cortex is the bark of the stems of Phellodendron amurense Ruprecht or P. chinense Schneider (Rutaceae), which is orginated from periderm...
  54. Kuo P, Hsu M, Damu A, Su C, Li C, Sun H, et al. Flavonoids and coumarins from Leaves of Phellodendron chinense. Planta Med. 2004;70:183-5 pubmed
    Three new compounds, phellodensin G, phellodenols D and E have been isolated from the leaves of Phellodendron chinense Schneid (Rutaceae), together with thirteen known compounds...
  55. Tsai J, Tsai S, Chang W. Comparison of two Chinese medical herbs, Huangbai and Qianniuzi, on influence of short circuit current across the rat intestinal epithelia. J Ethnopharmacol. 2004;93:21-5 pubmed
    Huangbai (Phellodendron spec.) and Qianniuzi (Pharbitis spec.) are two traditional Chinese medical herbs used for anti-diarrheal and laxative agents, respectively...
  56. Liu Q, Zhou B, Wang X, Ke Y, Jin Y, Yin L, et al. Establishment of a search library about benzylisoquinoline alkaloids based on selective separation on the binaphthyl column and standard analysis on C18 column. J Sep Sci. 2012;35:3317-25 pubmed publisher
    ..In addition, the distribution of benzylisoquinoline alkaloids in the herbal medicines could be also summarized by searching the source samples in the library. ..
  57. Zhang M, Zhu J, Yan Q. [Effects of light quality on the seed germination of main tree species in a secondary forest ecosystem of Northeast China]. Ying Yong Sheng Tai Xue Bao. 2012;23:2625-31 pubmed
    ..explored the effects of light quality on the seed germination of five dominant tree species (Larix kaempferi, Phellodendron amurense, Acer mono, Fraxinus mandshurica, and Pinus koraiensis) in a secondary forest ecosystem of Northeast ..
  58. Zhang X, Zhao K, Dai Q, Li L, Zhang B. [The effects of the tangfukang capsules on cytokines of early diabetic nephropathy]. Zhongguo Zhong Yao Za Zhi. 2003;28:452-5 pubmed
    ..It may be the partical mechanism of Tangfukang to suppress the monenzymatic glycosylation of protein and to reduce the expression of cytokine in diabetes. The effect of Tangfukang is superior to that of aminoguanidine. ..
  59. Domingues V, Alves A, Cabral M, Delerue Matos C. Sorption behaviour of bifenthrin on cork. J Chromatogr A. 2005;1069:127-32 pubmed
    ..The results obtained in this work indicate that cork wastes may be used as a cheap natural sorbent for bifenthrin or similar compounds removal from wastewaters. ..
  60. Li C, Xie J, Chen X, Mo Z, Wu W, Liang Y, et al. Comparison of Helicobacter pylori Urease Inhibition by Rhizoma Coptidis, Cortex Phellodendri and Berberine: Mechanisms of Interaction with the Sulfhydryl Group. Planta Med. 2016;82:305-11 pubmed publisher
    ..The concentration- and time-dependent, reversible, and noncompetitive inhibition against urease by C. chinensis might be attributed to its interaction with the sulfhydryl group of the active site of urease. ..
  61. Cai Y, Wang S, Guo W, Xie Z, Zheng Y, Cao Z, et al. Transcriptome analysis provides insights into the immune responsive pathways and genes in the head kidney of tiger grouper (Epinephelus fuscoguttatus) fed with Spatholobus suberectus, Phellodendron amurense, or Eclipta prostrata. Fish Shellfish Immunol. 2018;73:100-111 pubmed publisher
    ..Spatholobus suberectus (S), Phellodendron amurense (P), and Eclipta prostrate (E) are three commonly used Chinese medicinal herbs...
  62. Yang C, Zhu J, Wang Y, Wen Y, Kong L. [Effects of processing Phellodendron amurense with salt on anti-gout]. Zhongguo Zhong Yao Za Zhi. 2005;30:145-8 pubmed
    To investigate the effects of processing Phellodendron anurene with salt on anti-gout.
  63. Leu C, Li C, Yao X, Wu T. Constituents from the leaves of Phellodendron amurense and their antioxidant activity. Chem Pharm Bull (Tokyo). 2006;54:1308-11 pubmed
    ..F-H (1-3) and a new glutaric acid derivative, phellodendric acid-A (4) were isolated from the leaves of Phellodendron amurense together with twenty-nine known compounds...
  64. Wang H, Wang Y, Zu Y, Sun L. [Construction and analysis of subtractive cDNA library of Phellodendron amurense under drought stress]. Sheng Wu Gong Cheng Xue Bao. 2008;24:198-202 pubmed
    With cDNA from Phellodendron amurense seedlings treated with drought stress as tester and cDNA from this plant in normal growth as driver, we construct cDNA subtracted library using suppression subtractive hybridization (SSH)...
  65. Zhang L. [Optimization of technology conditions from Ermiao Wan decoction by semi-bionic extraction method]. Zhongguo Zhong Yao Za Zhi. 2012;37:2396-9 pubmed
    ..To optimize the technology of Ermiao Wan decoction by SBE with uniform design...
  66. Wang Y, Ma D, Yu C. [Studies on chromosomes preparation and karyotype analysis of Phellodendron chinense]. Zhong Yao Cai. 2005;28:3-5 pubmed
    The article reported method of making chromosomes by callus and used in karyotype analysis of Phellodendron chinense. The results demonstrated that the chromosme amount to 80. The karyotype formula is K(2N) =80 =68m(2SAT) +6sm +6T...
  67. Li X, Yan X, Yu T. [Effects of water stress on protective enzyme activities and lipid peroxidation in Phellodendron amurense seedlings]. Ying Yong Sheng Tai Xue Bao. 2005;16:2353-6 pubmed proline contents, and of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities in Phellodendron amurense seedlings...
  68. Wang M, Ji T, Yang J, Su Y. [Studies on the chemical constituents of Phellodendron chinense]. Zhong Yao Cai. 2009;32:208-10 pubmed
    To isolate and identify chemical constituents from Phellodendron chinense.
  69. Mao Y, Li Y, Zong L, You X, Lin F, Jiang L. Methanol extract of Phellodendri cortex alleviates lipopolysaccharide-induced acute airway inflammation in mice. Immunopharmacol Immunotoxicol. 2010;32:110-5 pubmed publisher
    ..The effects of methanol extract of Phellodendri cortex on acute airway inflammation induced by intranasal administration of lipopolysaccharide (LPS, 300mug/kg) were investigated in female BALB/c mice...
  70. Wu T, Hsu M, Kuo P, Sreenivasulu B, Damu A, Su C, et al. Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity. J Nat Prod. 2003;66:1207-11 pubmed
    ..2R)-sodium 3-phenyllactate (7), in addition to 35 known compounds have been isolated from the leaves of Phellodendron amurense var. wilsonii...
  71. Insa S, Salvado V, Antico E. Development of solid-phase extraction and solid-phase microextraction methods for the determination of chlorophenols in cork macerate and wine samples. J Chromatogr A. 2004;1047:15-20 pubmed
    ..5%-5% (n=8) for a concentration level of 30 ng/L...
  72. Ezquerro O, Tena M. Determination of odour-causing volatile organic compounds in cork stoppers by multiple headspace solid-phase microextraction. J Chromatogr A. 2005;1068:201-8 pubmed
    ..Significant losses of analytes were observed when the samples were ground at room temperature. Finally, a recovery study was performed and the MHS-SPME results were validated using Soxhlet extraction results...
  73. Ikarashi N, Tajima M, Suzuki K, Toda T, Ito K, Ochiai W, et al. Inhibition of preadipocyte differentiation and lipid accumulation by Orengedokuto treatment of 3T3-L1 cultures. Phytother Res. 2012;26:91-100 pubmed publisher
    ..These findings suggest that an antiobesity effect could be a new indication for Orengedokuto and that its active ingredient is berberine, with a mechanism involving the inhibition of PPAR? and C/EBP? expression...
  74. Honda K, Omura H, Chachin M, Kawano S, Inoue T. Synergistic or antagonistic modulation of oviposition response of two swallowtail butterflies, Papilio maackii and P. protenor, to Phellodendron amurense by its constitutive prenylated flavonoid, phellamurin. J Chem Ecol. 2011;37:575-81 pubmed publisher
    Papilio maackii females prefer a rutaceous plant, Phellodendron amurense, for oviposition, whereas another semi-sympatric Rutaceae feeder, Papilio protenor, never exploits this plant as a host in nature...
  75. Martínez Uruñuela A, González Sáiz J, Pizarro C. Optimisation of a headspace solid-phase microextraction method for the direct determination of chloroanisoles related to cork taint in red wine. J Chromatogr A. 2004;1056:49-56 pubmed
  76. Lorenzo C, Zalacain A, Alonso G, Salinas M. Non-destructive method to determine halophenols and haloanisoles in cork stoppers by headspace sorptive extraction. J Chromatogr A. 2006;1114:250-4 pubmed
    ..91 and 12.67%. The effect of the different cork matrixes on the extraction recovery of the target compounds was studied, with the natural corks showing the higher recovery percentage in relation to agglomerate ones...
  77. Wang Y. [Studies on polyploid induction of Phellodendron chinense]. Zhongguo Zhong Yao Za Zhi. 2006;31:448-51 pubmed
    This paper aimed at improving existing breeds of Phellodendron chinense and enriching the resources of heredity breeding.
  78. Ren L, Xue X, Zhang F, Xu Q, Liang X. High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs. J Sep Sci. 2007;30:833-42 pubmed
    ..The possible fragmentation pathways of protoberberine alkaloids in APCI/MS analysis were studied for the first time in the present work...
  79. Yan Z, Zhang B, Zhang Z. [Genetic diversity evaluation of ex-situ conservation population of Phellodendron amurense detected by AFLP markers]. Zhongguo Zhong Yao Za Zhi. 2008;33:1121-5 pubmed
    To evaluate the genetic diversity from ex-situ conservation population of Phellodendron amurense.
  80. Mao P, Xu J, Wu Y. [Study on releasing rate of chrysophanol from Ruyi Jinhuang plaster]. Zhongguo Zhong Yao Za Zhi. 2004;29:746-7, 816 pubmed
    ..To study the releasing rate of chrysophanol from Ruyi Jinhuang plaster...
  81. Lee J, Lee D, Yu H, Kim J, Lee J. Isolation and characterization of a novel glutathione S-transferase-activating peptide from the oriental medicinal plant Phellodendron amurense. Peptides. 2006;27:2069-74 pubmed
    ..Among 265 kinds of medicinal plants, Phellodendron amurense showed the highest GST activity at 174.8%. The GST-activating compound of P...
  82. Hu Y, Su G, Sze S, Ye W, Tong Y. Quality assessment of Cortex Phellodendri by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry. Biomed Chromatogr. 2010;24:438-53 pubmed publisher
    ..developed for the quality assessment of Cortex Phellodendri (CP), which was mainly derived from two species of Phellodendron chinense Schneid and Phellodendron amurense Rupr...
  83. Chen S, Chien C, Baskin J, Baskin C. Storage behavior and changes in concentrations of abscisic acid and gibberellins during dormancy break and germination in seeds of Phellodendron amurense var. wilsonii (Rutaceae). Tree Physiol. 2010;30:275-84 pubmed publisher
    The medicinal Asian plant genus Phellodendron is known to contain several very important compounds that have biological action. The main purpose of this study was to determine whether seeds of Phellodendron amurense var...
  84. Li Y, Zhang T, Zhang X, Xu H, Liu C. Chemical fingerprint analysis of Phellodendri Amurensis Cortex by ultra performance LC/Q-TOF-MS methods combined with chemometrics. J Sep Sci. 2010;33:3347-53 pubmed publisher
    ..The developed fingerprint assay is a powerful method that may be used to conduct quality control of PAC...
  85. Zhang C. [Determination of obacunone and obaculactone in different processing products of Phellodendri amurensis cortex]. Zhong Yao Cai. 2013;36:205-8 pubmed
    ..To study the impact of different processing methods on the content of limonin compounds in Phellodendri Amurensis Cortex...
  86. Wei P, Chen L, Wei Y, Yuan J, Ma J, Chen L. [Determination of alkaloids from Coptis chinensis Franch. and Phellodendron amurense Rupr. Decocted together in baitouweng decocta by high performance capillary electrophoresis]. Se Pu. 2002;20:554-6 pubmed
    A rapid and accurate method for determining alkaloids from Coptis chinensis Franch, and Phellodendron amurense Rupr, decocted together in Baitouweng decocta was established...
  87. Zhao R, Zhao L, Zhou Y, Li D, Hao W, Chen K. [Experimental study of Bailian Caogen granule on pharmacodynamics]. Zhongguo Zhong Yao Za Zhi. 2006;31:672-5 pubmed
    ..To study the analgesic, antipyretic and anti-inflammatory effect of Bailian Caogen granule...
  88. Wang Y, Gou X, Wu J, Yan W, Ma X, Yang Y. [Hairy roots induction of Phellodendron chinense and production of its active constituents]. Zhongguo Zhong Yao Za Zhi. 2006;31:1853-6 pubmed
    To introduce the hairy roots of Phellodendron chinense and determine the content of its active constituents.
  89. Li J, Liu X, Cai B, Fu X. [Studies on NACE-DAD fingerprint of Cortex Phellodendri]. Zhong Yao Cai. 2010;33:349-52 pubmed
    ..To establish the analytical method for the fingerprint of Cortex Phellodendri by NACE-DAD and estimate the quality of Cortex Phellodendri from different habitats and species...
  90. Zhang Z, Xia T, Tao Y, Dai L, Liu Y, Zhang B. [Study on allelopathy effect of pericarp extract of Phellodendron amurense]. Zhongguo Zhong Yao Za Zhi. 2011;36:285-8 pubmed
    Through the study of allelopathy of the pericarp of Phellodendron amurense, the role of self-regeneration barriers was investigated in order to find ways and means for the protection of wild populations of P. amurense...
  91. Yang J, Zhao B, Kim Y, Zhou C, Li C, Chen Y, et al. Agrobacterium tumefaciens-mediated transformation of Phellodendron amurense Rupr. using mature-seed explants. Mol Biol Rep. 2013;40:281-8 pubmed publisher
    An efficient transformation protocol was developed for Agrobacterium-mediated transformation of Phellodendron amurense Rupr. for using explants from mature seeds...
  92. Wang H, Zhang Z, Dai L, Si J, Zhang B, Li Y, et al. [Research on allelopathic effects of phellamurine]. Zhongguo Zhong Yao Za Zhi. 2013;38:2768-72 pubmed
    Conducted research on new allelochemicals phellamurine extracted from deciduous of Phellodendron amurense, which worked in allelopathy effect to seed germination and growth process of P. amurense and P...