evodia

Summary

Summary: A plant genus of the family RUTACEAE which is used in Chinese medicine (DRUGS, CHINESE HERBAL). Evodiamine and other quinazoline alkaloids (QUINAZOLINES) are obtained from the fruit of E. ruticarpa.

Top Publications

  1. Wang Q, Liang J. [Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth]. Yao Xue Xue Bao. 2004;39:605-8 pubmed
    To study the chemical constituents of Evodia rutaecarpa (Juss.) Benth.
  2. Pellati F, Benvenuti S, Yoshizaki F, Melegari M. Development and validation of HPLC methods for the analysis of phenethylamine and indoloquinazoline alkaloids in Evodia species. J Sep Sci. 2006;29:641-9 pubmed
    ..and indoloquinazoline (rutaecarpine and evodiamine) alkaloids in methanolic extracts of fruits of Evodia rutaecarpa (Juss.) Benth. and E. rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (i.e., E...
  3. Ko H, Chen K, Chen C, Su J, Chen C, Wang G. Chemical and biological comparisons on Evodia with two related species of different locations and conditions. J Ethnopharmacol. 2006;108:257-63 pubmed
    b>Evodia rutaecarpa (ER) and Tetradium glabrifolium (TG) are closely related species collected from different locations, with processed versus unprocessed and fresh versus 1-year-old samples...
  4. Xu S, Peng J, Li Y, He L, Chen F, Zhang J, et al. Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats. J Ethnopharmacol. 2012;139:395-400 pubmed publisher
    ..The bioavailability of Rut and Evo was increased along with the increasing of purity (16%-80%) in Wu-Chu-Yu extracts. ..
  5. Chao D, Lin L, Kao S, Huang H, Chang C, Liang J, et al. Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-?B, and cellular transformation in HepG2 cells. Fitoterapia. 2011;82:696-703 pubmed publisher
    ..ZJW and its components, Coptis chinensis and Evodia rutaecarpa, inhibited AP-1 and NF-?B activities, and suppressed anchorage-independent growth of HepG2 cells...
  6. Yarosh D, Galvin J, Nay S, Pena A, Canning M, Brown D. Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine. J Dermatol Sci. 2006;42:13-21 pubmed
    Wu-Zhu-Yu, is an extract prepared from the small berry fruit of Evodia rutaecarpa and is reported to have anti-inflammatory and anti-nociceptic activity...
  7. Chiou W, Ko H, Chen C, Chou C. Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release. J Pharm Pharmacol. 2002;54:1399-405 pubmed
    Using a rat model of septic shock we studied the effects of Evodia rutaecarpa, a Chinese herbal medicine with antimicrobial and anti-inflammatory activity, on haemodynamic parameters, biochemical markers of organ function and nitric oxide ..
  8. Adams M, Wube A, Bucar F, Bauer R, Kunert O, Haslinger E. Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds. Int J Antimicrob Agents. 2005;26:262-4 pubmed
  9. Ko H, Wang Y, Liou K, Chen C, Chen C, Wang W, et al. Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells. Eur J Pharmacol. 2007;555:211-7 pubmed
    b>Evodia rutaecarpa is commonly used as an anti-inflammatory drug in traditional Chinese medicine...

More Information

Publications120 found, 100 shown here

  1. Zhou X, Zhao Y, Lei P, Cai Z, Liu H. Chromatographic fingerprint study on Evodia rutaecarpa (Juss.) Benth by HPLC/DAD/ESI-MS(n) technique. J Sep Sci. 2010;33:2258-65 pubmed publisher
    ..As a result, those which had same chemical properties were sorted into one cluster, which was very useful in evaluating and controlling the quality of Wuzhuyu...
  2. Gao X, Yang X, Marriott P. Simultaneous analysis of seven alkaloids in Coptis-Evodia herb couple and Zuojin pill by UPLC with accelerated solvent extraction. J Sep Sci. 2010;33:2714-22 pubmed publisher
    ..berberine, palmatine, coptisine, jatrorrhizine, epiberberine, evodiamine, and rutaecarpine, in the Coptis-Evodia herb couple and the Zuojin pill preparation...
  3. Dong G, Wang S, Miao Z, Yao J, Zhang Y, Guo Z, et al. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. J Med Chem. 2012;55:7593-613 pubmed publisher
    ..They represent promising candidates for the development of novel antitumor agents...
  4. Wang X, Zan K, Shi S, Zeng K, Jiang Y, Guan Y, et al. Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa. Fitoterapia. 2013;89:1-7 pubmed publisher
    ..four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence...
  5. Kobayashi Y. The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice. Planta Med. 2003;69:425-8 pubmed
    Recently, the authors reported that evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), had vanilloid receptor agonistic activity comparable to capsaicin...
  6. Ueng Y, Yu H, Lee C, Peng C, Jan W, Ho L, et al. Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa. J Chromatogr A. 2005;1076:103-9 pubmed
    Rutaecarpine is a quinazolinocarboline alkaloid of the medicinal herb Evodia rutaecarpa and shows a variety of pharmacological effects...
  7. Pellati F, Benvenuti S, Yoshizaki F, Bertelli D, Rossi M. Headspace solid-phase microextraction-gas chromatography--mass spectrometry analysis of the volatile compounds of Evodia species fruits. J Chromatogr A. 2005;1087:265-73 pubmed
    In this study the investigation of the aroma compounds of dried fruits of Evodia rutaecarpa (Juss.) Benth. and E. rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (i.e. E...
  8. Choi Y, Shin E, Kim Y, Cai X, Lee J, Kim H. Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. Arch Pharm Res. 2006;29:293-7 pubmed
    The fruits of Evodia rutaecarpa Benth (Rutaceae) has long been used for inflammatory disorders and some anti-inflammatory actions of its constituents such as dehydroevodiamine, evodiamine and rutaecarpine were previously reported...
  9. Shin Y, Bae E, Cai X, Lee J, Kim D. In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents. Biol Pharm Bull. 2007;30:197-9 pubmed
    The unripe fruit of Evodia rutaecarpa (JUSS) BENTH (ER, Family Rutaceae) has been used frequently as a traditional medicine against inflammatory diseases in Korea, China and Japan...
  10. Kato A, Yasuko H, Goto H, Hollinshead J, Nash R, Adachi I. Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2009;16:258-61 pubmed
    ..Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine...
  11. Adams M, Mahringer A, Kunert O, Fricker G, Efferth T, Bauer R. Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa. Planta Med. 2007;73:1554-7 pubmed
    ..as well as the indoloquinazoline alkaloids rutaecarpine and evodiamine - all from the Chinese medicinal herb Evodia rutaecarpa - were tested in two in vitro assays, for cytotoxicity and interaction with p-glycoprotein (p-gp)...
  12. Zhao Y, Li Z, Zhou X, Cai Z, Gong X, Zhou C. Quality evaluation of Evodia rutaecarpa (Juss.) Benth by high performance liquid chromatography with photodiode-array detection. J Pharm Biomed Anal. 2008;48:1230-6 pubmed publisher
    ..was developed for simultaneous determination of wuchuyuamide-I, quercetin, limonin, evodiamine and rutaecarpine in Evodia rutaecarpa that has been widely used as one of the traditional Chinese medicines (TCMs)...
  13. Yoon J, Jeong H, Kim S, Kim H, Nam G, Kim J, et al. Methanol extract of Evodia lepta displays Syk/Src-targeted anti-inflammatory activity. J Ethnopharmacol. 2013;148:999-1007 pubmed publisher
    b>Evodia lepta (Spreng.) Merr., in the Rutaceae family, is a medicinal plant traditionally used to treat inflammatory symptoms such as in meningitis and hepatitis...
  14. Jin H, Lee J, Lee D, Lee H, Hong Y, Kim Y, et al. Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa. Biol Pharm Bull. 2004;27:926-8 pubmed
    Nine quinolone alkaloids (1-9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-kappa B-..
  15. Xu M, Li G, Moon D, Lee C, Woo M, Lee E, et al. Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis. Arch Pharm Res. 2006;29:541-7 pubmed
    ..1-4), three quinolone alkaloids (5-7), and three flavanoid glucosides (8-10) were isolated from the fruits of Evodia officinalis Dode, and their structures were determined from chemical and spectral data...
  16. Yu X, Wu D. [Protective effects of Evodia rutaecarpa water extract on ethanol-induced rat gastric lesions]. Zhongguo Zhong Yao Za Zhi. 2006;31:1801-3 pubmed
    To investigate the protective effects of Evodia rutaecarpa water extract on ethanol-induced acute gastric lesions in rats.
  17. Barrows L, Powan E, Pond C, Matainaho T. Anti-TB activity of Evodia elleryana bark extract. Fitoterapia. 2007;78:250-2 pubmed
    An ethyl acetate extract of bark from Evodia elleryana produced significant growth inhibition of Mycobacterium tuberculosis at concentrations only minimally inhibitory to human T cells...
  18. Wang X, Xu L, Peng J, Liu K, Zhang L, Zhang Y. In vivo inhibition of S180 tumors by the synergistic effect of the Chinese medicinal herbs Coptis chinensis and Evodia rutaecarpa. Planta Med. 2009;75:1215-20 pubmed publisher
    ..effect and mechanism of anticancer activity of Zuojinwan ( ZJW) comprising Coptis chinensis Franch ( HL) and Evodia rutaecarpa (Juss.) Benth ( WZY) at a ratio of 6 : 1 (w/w)...
  19. Hu C, Xiao L, Deng H, Li Y. The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin gene-related peptide. Planta Med. 2003;69:125-9 pubmed
    ..These results suggest that the depressor and vasodilator effects of rutaecarpine are related to stimulation of endogenous CGRP release via activation of vanilloid receptors in rats...
  20. Zhang Y, Zhang Q, Wu L, Tashiro S, Onodera S, Ikejima T. Atypical apoptosis in L929 cells induced by evodiamine isolated from Evodia rutaecarpa. J Asian Nat Prod Res. 2004;6:19-27 pubmed
    Two alkaloids, evodiamine and rutaecarpine, isolated from the dried fruits of Evodia rutaecarpa Bentham were evaluated in vitro for antiproliferation activity on tumor cells versus human peripheral blood mononuclear cells (PBMC)...
  21. Adams M, Kunert O, Haslinger E, Bauer R. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004;70:904-8 pubmed
    The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes...
  22. Ueng Y, Tsai T, Don M, Chen R, Chen T. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. J Pharm Pharmacol. 2005;57:227-32 pubmed
    Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa...
  23. Tsai T, Chang C, Lin L. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med. 2005;71:640-5 pubmed
    To assess possible herb-drug interactions, rutaecarpine (an herbal ingredient of Evodia rutaecarpa; 25 mg/kg/day, p. o.), the ethanol extract of Evodia rutaecarpa (1 g/kg/day, p. o...
  24. Jiang J, Hu C. Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa. Molecules. 2009;14:1852-9 pubmed publisher
    ..b>Evodia rutaecarpa is a very popular multi-purpose herb traditionally used in China for the treatment of headaches, ..
  25. Zhao Y, Zhou X, Chen H, Gong X, Cai Z, Zhou C. Determination of dehydroevodiamine in Evodia rutaecarpa (Juss.) Benth by high performance liquid chromatography and classification of the samples by using hierarchical clustering analysis. Fitoterapia. 2009;80:415-20 pubmed publisher
    ..different regions of China, and hierarchical clustering analysis was firstly used to classify and differentiate Evodia rutaecarpa samples. The analysis is specific and can be successfully applied to analyze E...
  26. Liu Z, Liu Q, Du S, Deng Z. Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae). Parasitol Res. 2012;111:991-6 pubmed publisher
    ..screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the ethanol extract of Evodia rutaecarpa Hook f...
  27. Chen F, Li S, Li D, Ding J. Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo. Fitoterapia. 2012;83:954-60 pubmed publisher
    Evodiamine (EVO) and rutaecapine (RUT), the major active components from Evodia rutaecarpa extract (EE), are recognized as a depended analgesic agent...
  28. Liao C, Pan S, Guh J, Chang Y, Pai H, Lin C, et al. Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis. 2005;26:968-75 pubmed
    ..Evodiamine therefore represents a highly promising chemotherapeutic agent in the treatment of human multiple-drug resistant cancer cells. ..
  29. Liu R, Chu X, Sun A, Kong L. Preparative isolation and purification of alkaloids from the Chinese medicinal herb Evodia rutaecarpa (Juss.) Benth by high-speed counter-current chromatography. J Chromatogr A. 2005;1074:139-44 pubmed
    ..system (5:5:7:5, v/v) was applied to the isolation and purification of alkaloids from the Chinese medicinal plant Evodia rutaecarpa (Juss.) Benth...
  30. Dong L, Shi H, Ji G, Wu D. [Effects of Coptis chinensis and Evodia rutaecarpa water extract on DMH-induced precancerous lesion of colon]. Zhongguo Zhong Yao Za Zhi. 2010;35:1185-8 pubmed
    To investigate the effects of Coptis chinensis and Evodia rutaecarpa water extract on precancerous lesion of colon induced by DMH and proliferation and apoptosis changes of colon mucosa crypts...
  31. Qu S, Liu Q, Tan C, Jiang S, Zhu D. New indole N-oxide alkaloids from Evodia fargesii. Planta Med. 2006;72:264-6 pubmed
    ..2), and bufotenine 5-O-beta-D-glucopyranoside N(12)-oxide (3), were isolated from the root and stem of Evodia fargesii Dode along with five known compounds...
  32. Lee T, Kim E, Kim S, Jung E, Park J, Jeong S, et al. Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells. Mol Cancer Ther. 2006;5:2398-407 pubmed
    ..Thus, therapeutic strategy using evodiamine may warrant further evaluation. ..
  33. Lu Y, Ma W, Hu R, Berthod A, Pan Y. Rapid and preparative separation of traditional Chinese medicine Evodia rutaecarpa employing elution-extrusion and back-extrusion counter-current chromatography: comparative study. J Chromatogr A. 2009;1216:4140-6 pubmed publisher
    ..In this paper, a popular traditional Chinese medicine, Evodia rutaecarpa, was used as the target complex mixture for extrusion CCC separations...
  34. Song Y, Wang Z, Zhu J, Yan L, Zhang Q, Gong M, et al. [Assay of evodin, evodiamine and rutaecarpine in Fructus Evodiae by QAMS]. Zhongguo Zhong Yao Za Zhi. 2009;34:2781-5 pubmed
    ..It is feasible and suitable to determine evodin and evodiamine in Fructus Evodiae by QAMS, and this method can be used for a certain different types of compounds. ..
  35. Pan L, Lu X, Xu H, Wu P. [Study on content variation of chemical constituents during combination of rhizoma coptidis alkaloids with fructus evodiae flavonoids by high performance liquid chromatography]. Se Pu. 2006;24:168-70 pubmed
    ..No chemical reactions were observed during the compatibility test of rhizoma coptidis alkaloids with fructus evodiae flavonoids. ..
  36. Wu W, Chien C, Liu K, Chen Y, Chiu W. Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation. Am J Chin Med. 2017;45:879-899 pubmed publisher
    Evodiamine (EVO) is an active medicinal compound derived from the traditional herbal medicine Evodia rutaecarpa...
  37. Yang D, Li L, Qian S, Liu L. Evodiamine ameliorates liver fibrosis in rats via TGF-?1/Smad signaling pathway. J Nat Med. 2018;72:145-154 pubmed publisher
    ..Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities...
  38. Zhou Y, Li S, Jiang R, Cai M, Liu X, Ding L, et al. Quantitative analyses of indoloquinazoline alkaloids in Fructus Evodiae by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20:3111-8 pubmed
    Fructus Evodiae (Wuzhuyu), the fruits of Evodia rutaecarpa and related varieties, is widely used in traditional Chinese medicine...
  39. Zhang Q, Xu G, Wu L, Ma X, Zeng Z, Huang L, et al. [Preliminary study of metabonomcs on aqueous extract of Evodia rutaecarpa in sprague-dawley rats]. Zhongguo Zhong Yao Za Zhi. 2010;35:99-102 pubmed
    ..The E. rulaecarpa has changed the endogenous metabolites of SD rats. This work can provide the base for the further research on the interpretation of drug property of E. rulaecarpa. ..
  40. Tan Q, Zhang J. Evodiamine and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;929:315-328 pubmed
    Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae)...
  41. Yu X, Wu D, Yuan J, Zhang R, Hu Z. Gastroprotective effect of fructus evodiae water extract on ethanol-induced gastric lesions in rats. Am J Chin Med. 2006;34:1027-35 pubmed
    ..These results suggested that FE prevented ethanol-induced gastric mucosal lesions by strengthening the mucosal barrier integrity and increasing gastric mucosal nitric oxide (NO) synthesis. ..
  42. Wang T, Wu J, Hwang T, Kuo Y, Chen J. A new quinolone and other constituents from the fruits of Tetradium ruticarpum: effects on neutrophil pro-inflammatory responses. Chem Biodivers. 2010;7:1828-34 pubmed publisher
    ..In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC(50) values < or =14.4 microM. ..
  43. Wattanapiromsakul C, Forster P, Waterman P. Alkaloids and limonoids from Bouchardatia neurococca: systematic significance. Phytochemistry. 2003;64:609-15 pubmed
    ..The pattern of secondary metabolites isolated is rather unusual in the Rutaceae and is reminiscent of Tetradium, a genus with which Bouchardatia has not previously been associated. ..
  44. Yi H, Rang W, Deng P, Hu C, Liu G, Tan G, et al. Protective effects of rutaecarpine in cardiac anaphylactic injury is mediated by CGRP. Planta Med. 2004;70:1135-9 pubmed
    ..These results suggest that the protective effects of rutaecarpine on cardiac anaphylactic injury are related to inhibition of TNF-alpha production by stimulation of CGRP release. ..
  45. Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T. Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract. Drug Metab Pharmacokinet. 2005;20:34-45 pubmed
    b>Evodia fruit (Evodiae Fructus) is used as a herbal medicine prepared from the matured fruit of the Evodia rutaecarpa Bentham or Evodia officinalis Dode, of the Rutaceae plant family...
  46. Yan R, Mu Q, Wang Y, Liu Y, Di X. Characterization and determination of the alkaloid metabolites of Evodiae fructus in rat urine by liquid chromatography-tandem mass spectrometry detection. Molecules. 2011;16:5822-32 pubmed publisher
    ..The fully validated method was applied to the pharmacokinetic study of the metabolites in rat urine. The results could provide evidence to explain the combination of Coptidis rhizoma and Evodiae fructus in terms of elimination. ..
  47. Qian P, Jin H, Yang X. New limonoids from Coptidis Rhizoma-Euodiae Fructus couple. J Asian Nat Prod Res. 2014;16:333-44 pubmed publisher
    ..Structures of these compounds were identified by spectral analyses and quantum chemical computational method, and the six limonoids were also evaluated for cytotoxicities against NCI-N87 and Caco-2 cell lines. ..
  48. Hun Son K, Young Heo M. Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis. J Cosmet Sci. 2013;64:145-58 pubmed
    ..of Smilax china (rhizome), Paeonia lactiflora (root), and Polyporus umbellatus (sclerotium), and BuOH fraction of Evodia officinalis (fruit)...
  49. Lee C, Gu J, Rau T, Yang C, Yang W, Huang S, et al. Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities. Biomed Res Int. 2013;2013:795095 pubmed publisher
    Rutaecarpine (RUT), the major bioactive ingredient isolated from the Chinese herb Evodia rutaecarpa, possesses a wide spectrum of biological activities, including anti-inflammation and preventing cardiovascular diseases...
  50. Unsworth W, Kitsiou C, Taylor R. An expedient protecting-group-free total synthesis of (±)-dievodiamine. Org Lett. 2013;15:3302-5 pubmed publisher
    The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described...
  51. Huang W, Sun R. [Study on analgesic and accompanying toxic and side effects of euodiae fructus based on clinical efficacy dose]. Zhongguo Zhong Yao Za Zhi. 2013;38:2176-81 pubmed
    ..Its analgesic mechanism is related to the reduction of PGE, content in blood, while its toxic mechanism is related to oxidative injury to some extent. ..
  52. Liang X, Li B, Wu F, Li T, Wang Y, Ma Q, et al. Bitterness and antibacterial activities of constituents from Evodia rutaecarpa. BMC Complement Altern Med. 2017;17:180 pubmed publisher
    ..The aim of this research was to evaluate bitterness of limonoids and alkaloids from Evodia rutaecarpa to demonstrate that they are main bitter material basic of E. rutaecarpa...
  53. Peng M, Wu Y, Cheng Y. [Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae]. Zhongguo Zhong Yao Za Zhi. 2003;28:629-32 pubmed
  54. Tominaga K, Higuchi K, Hamasaki N, Tanigawa T, Sasaki E, Watanabe T, et al. [Antibacterial activity of a Chinese herbal medicine, Gosyuyu (Wu-Chu-Yu), against Helicobacter pylori]. Nihon Rinsho. 2005;63 Suppl 11:592-9 pubmed
  55. Yamamoto M, Akita T, Koyama Y, Sueyoshi E, Matsunami K, Otsuka H, et al. Euodionosides A-G: megastigmane glucosides from leaves of Euodia meliaefolia. Phytochemistry. 2008;69:1586-96 pubmed publisher
    ..Their structures were elucidated through a combination of spectroscopic analyses and application of the modified Mosher's method. ..
  56. Minehira D, Takeda D, Urata H, Kato A, Adachi I, Wang X, et al. Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-?-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorg Med Chem. 2012;20:356-67 pubmed publisher
    ..were designed as the inhibitor of AKR1B1 based upon the structure of rhetsinine, a minor alkaloidal component of Evodia rutaecarpa, and twenty derivatives were synthesized and evaluated...
  57. Ahn H, Nam J, Seo E, Mar W. Induction of NAD(P)H: quinone reductase by rutaecarpine isolated from the fruits of Evodia rutaecarpa in the murine hepatic Hepa-1c1c7 cell line. Planta Med. 2008;74:1387-90 pubmed publisher
    Rutaecarpine is a quinazolinocarboline alkaloid isolated from Evodia rutaecarpa (Juss.), which has been used in traditional Chinese medicine...
  58. Weng X, Li Y, Yang Q, Wang Y, Liu X, Han X, et al. [Effects of Wuji pill compound with different compatibility on cytochrome P450 CYP3A1/3A2 in rat liver microsomes in vitro]. Zhongguo Zhong Yao Za Zhi. 2010;35:1164-9 pubmed
    ..Key words] Wuji pill; CYP3A1/3A2; testosterone; HPLC; different compatibility prescription of traditional Chinese medi-cine ..
  59. Zhao M, Yang X. Two new acylgluconic acids from the nearly ripe fruits of Evodia rutaecarpa. J Asian Nat Prod Res. 2008;10:769-73 pubmed publisher
    ..ester (4), and wuzhuyuamide-I (5), were isolated from the water soluble part of the dried nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth...
  60. Wang X, Zhou Q, Han X, Xu L, Peng J. [Anti-cancer activity of Zuojinwan in vivo and influence to tumor markers in mice transplanted with sarcoma 180]. Zhongguo Zhong Yao Za Zhi. 2008;33:2230-4 pubmed
    ..of five kinds of tumor markers (TM) including acid phosphotase (ACP), alkaline phosphotase (AKP), creatine kinase (CK), aldolase (ALD) and lactate dehydrogenase (LDH) in serum compared with Coptis chinensis and Evodia rutaecarpa.
  61. Yu P, Chao H, Wang S, Wang P. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. J Cell Biochem. 2009;108:469-75 pubmed publisher
  62. Ogasawara M, Matsunaga T, Takahashi S, Saiki I, Suzuki H. Anti-invasive and metastatic activities of evodiamine. Biol Pharm Bull. 2002;25:1491-3 pubmed
    ..Also, the presence of a methyl group at N-14 and the configuration of hydrogen at C-13 b may be responsible for the inhibitory activities of evodiamine. ..
  63. Gong X, Zhou X, Cai Z, Zhang J, Zhou W. [Studies on chemical constituents of Evodia rutaecarpa]. Zhongguo Zhong Yao Za Zhi. 2009;34:177-9 pubmed
    To study the constituents of Evodia rutaecarpa. The constituents were isolated by various chromatographic techniques and the structures were elucidated by their physicochemical properties and the spectral data analysis...
  64. Yang Z, Chen A, Liu B. Antiproliferation and apoptosis induced by evodiamine in human colorectal carcinoma cells (COLO-205). Chem Biodivers. 2009;6:924-33 pubmed publisher
    Evodiamine (1), a biologically active alkaloid isolated from Evodia rutaecarpa (known in Chinese as Wu-Chu-Yu), has antioxidant, anti-inflammatory, and anticancer activities...
  65. Koyama Y, Yamamoto M, Matsunami K, Otsuka H, Shinzato T, Takeda Y. Prenylated flavonoid glucoside and two aliphatic alcohol glycosides from the leaves of Euodia meliaefolia (Hance) Benth. J Nat Med. 2011;65:212-6 pubmed publisher
    ..Their structures were determined on the basis of the results of spectroscopic analysis. ..
  66. Chao D, Lin L, Hsiang C, Li C, Lo H, Liang J, et al. Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes. Phytother Res. 2011;25:1018-23 pubmed publisher
    b>Evodia rutaecarpa has been used to treat inflammatory digestive disorders in Asian countries. However, little is known about the antitumor activities of E. rutaecarpa and its bioactive constituent evodiamine (EVO)...
  67. Pan X, Hartley J, Hartley J, White K, Wang Z, Bligh S. Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. Phytomedicine. 2012;19:618-24 pubmed publisher
    ..which is a quinazolinocarboline alkaloid isolated from the fruit of a traditional Chinese medicinal plant, Evodia rutaecarpa...
  68. Xiao B, Mao S, Li X. Variations in the composition of Fructus Evodiae after processing with Radix Glycyrrhizae extract. Chin J Integr Med. 2012;18:782-7 pubmed publisher
    ..0 mL/min, and the injection volume was 10 ?L. The calibration curves of evodia lactone, evodiamine, rutaecarpine, liquiritin, and glycyrrhizin showed good linear relationships (r>0.99)...
  69. Ueng Y, Don M, Peng H, Wang S, Wang J, Chen C. Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes. Jpn J Pharmacol. 2002;89:267-73 pubmed
    ..E. Fructus and rutaecarpine contributed at least in part to the CYP1a2 induction by Wu-chu-yu-tang. Patients should be cautioned about the drug interaction of Wu-chu-yu-tang and CYP1A2 substrates. ..
  70. Teng J, Yang X. A new limonoid from the fruits of Evodia rutaecarpa (Juss.) Benth. Pharmazie. 2006;61:1038-40 pubmed
    Four limonoids have been isolated from the unripe fruits of Evodia rutaecarpa (Juss.) Benth...
  71. Wang Z, Hong Y, Wang W, Wang J, Gao H. [Methodological studies on equivalent relationship between granule for clinical prescription and clinical decoction of fructus evodiae]. Zhongguo Zhong Yao Za Zhi. 2007;32:1149-54 pubmed
  72. Yang X. [Toxicological assessment on safety of water and 70% ethanolic extracts of nearly ripe fruit of Evodia rutaecarpa]. Zhongguo Zhong Yao Za Zhi. 2008;33:1317-21 pubmed
    ..and mutagenic risk of the water extracts (ERWE) and 70% ethanol extracts (EREE) from the nearly ripe fruit of Evodia rutaecarpa, and provide experimental basis for safety evaluation of ones...
  73. Jia X, Jiang J, Chen B, Chen Y, Hao K, Cai B, et al. [Progress in research of processing of fructus Evodiae-Rhizoma Coptidis and research thoughts and methods of its processing mechanism]. Zhongguo Zhong Yao Za Zhi. 2009;34:1314-7 pubmed
  74. Huang X, Li W, Yang X. New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa. Fitoterapia. 2012;83:709-14 pubmed publisher
    ..product, 1-methyl-2-[(E)-1-undecenyl]-4(1H)-quinolone (4), were isolated from the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., along with thirteen known compounds (5-17)...
  75. Wang C, Wang M, Tashiro S, Onodera S, Ikejima T. [Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine]. Yao Xue Xue Bao. 2005;40:1033-6 pubmed
    ..PKC lies upstream and exhibits regulatory effect on ERK and Bcl-2 in evodiamine-induced cell death. ..
  76. Han X, Hong S, Lee D, Lee J, Lee M, Moon D, et al. Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Arch Pharm Res. 2007;30:397-401 pubmed
    ..The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots. ..
  77. Peng Q, Yang D, Shi J, Cai H, Mo Z. [Proportion of Coptidis rhizoma and Evodiae fructus in the compound preparation: its effect in inducing apoptosis of SGC-7901 cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:226-9 pubmed
    ..CREF can inhibit the growth and induce apoptosis of SGC-7901 cells, and the strongest effect is achieved at the optimal proportion of Coptidis Rhizoma and Evodiae Fructus at 6:1. ..
  78. Fang Y, Shi Q. [Studies on preparation and dissolution test in vitro of intragastric floating two-chamber osmotic pump tablets of total alkaloids of Coptis chinensis and Evodia rutaecarpa]. Zhong Yao Cai. 2011;34:779-82 pubmed
    ..of intragastric floating two-chamber osmotic pump tablets (TCOPT) of total alkaloids of Coptis chinensis and Evodia rutaecarpa and inspect release property in vitro...
  79. Olah Z, Rédei D, Pecze L, Vizler C, Jósvay K, Forgo P, et al. Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1. Phytomedicine. 2017;34:44-49 pubmed publisher
    ..b>Evodia species, used in traditional medicine for hundreds of years, are a recognised source of different TRPV1 agonists, ..
  80. Mao B, Wang D. [Research on the changes of name of Wuzhuyu (Medicinal Evodia Fruit)]. Zhonghua Yi Shi Za Zhi. 2010;40:21-3 pubmed
    The name of Wuzhuyu (Medicinal Evodia Fruit) comes from the place of "Wu", and the shape of its fruit, which is like a 'Zhuyu'...
  81. Wu J, Zhang W, Shao Y, Fu S. Plant-facilitated effects of exotic earthworm Pontoscolex corethrurus on the soil carbon and nitrogen dynamics and soil microbial community in a subtropical field ecosystem. Ecol Evol. 2017;7:8709-8718 pubmed publisher
    ..exotic endogeic species Pontoscolex corethrurus) and plants (living plants [native tree species Evodia lepta] and artificial plants) to investigate their combined effects on soil microorganisms, soil nutrients, ..
  82. Zhang T, Wang M, Chen S. [Anti-emetic effect of ethanol extract from "Wuzhuyu broth"]. Zhongguo Zhong Yao Za Zhi. 2002;27:862-6 pubmed
    ..To investigate the anti-emetic effect of ethanol extract from "WuZhuYu broth" and its mechanism...
  83. Hibino T, Yuzurihara M, Kanno H, Kase Y, Takeda A. Goshuyuto, a traditional Japanese medicine, and aqueous extracts of Evodiae Fructus constrict isolated rat aorta via adrenergic and/or serotonergic receptors. Biol Pharm Bull. 2009;32:237-41 pubmed
    ..Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips...
  84. Wang L, Xiao H, Liang X, Bi K. [Vectorial angle method for evaluating the similarity between two chromatographic fingerprints of Chinese herb]. Yao Xue Xue Bao. 2002;37:713-7 pubmed
    ..To evaluate the similarity between two chromatographic fingerprints automatically with computer...
  85. Gai L, Rao G, Song C, Hu Z. [Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang]. Yao Xue Xue Bao. 2001;36:743-5 pubmed
    To study the chemical constituents of the unriped fruits from Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang.
  86. Rang W, Du Y, Hu C, Ye F, Tan G, Deng H, et al. Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:306-11 pubmed
    ..that the pharmacological effects of evodiamine, a major alkaloidal component of the dried, unripe fruit of Evodia rutaecarpa Bentham (Rutaceae), are associated with stimulation of calcitonin gene-related peptide (CGRP) release ..
  87. Wang J, Shen Y, He H, Kang W, Hao X. Norsesquiterpenoid and sesquiterpenoid glycosides from Evodia austrosinensis. Planta Med. 2005;71:96-8 pubmed
    ..B, citroside A, icariside B1 and dihydrophaseic acid 4'- O-beta- D-glucopyranoside were isolated from Evodia austrosinensis. Their structures were elucidated by 1D and 2D NMR data...
  88. Takada Y, Kobayashi Y, Aggarwal B. Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. J Biol Chem. 2005;280:17203-12 pubmed
    Evodiamine, an alkaloidal component extracted from the fruit of Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae), exhibits antiproliferative, antimetastatic, and apoptotic activities through a poorly defined mechanism...
  89. Jan W, Lin L, Chieh Fu Chen -, Tsai T. Herb-drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats. J Ethnopharmacol. 2005;102:440-5 pubmed
    The extract of Evodia rutaecarpa fruit and its preparation were used for the treatment of gastrointestinal disorders and headache...
  90. Liao Q, Xie Z, Zhang L, Deng Y, Li C, Wei C, et al. [Mass spectrometric analysis of quinazoline alkaloid and limonin from Fructus Evodiae]. Zhong Yao Cai. 2008;31:673-6 pubmed
    ..To study Mass spectrometry of quinazoline alkaloid and limonin from Fructus Evodiae by an electrospray ionization (ESI) tandem mass spectrometry...
  91. Han X, Bian B, Li R, Zhang Z, Ma Y, Yuan S. [Optimal processing techniques of preparing evodiae juice by orthognal experiment]. Zhongguo Zhong Yao Za Zhi. 2009;34:3025-9 pubmed
    ..To study and establish the optimal technology for the preparation of evodiae juice...
  92. Yang H, Zhao Y, Li B, Wang J, Li R, Jia L, et al. [COLD or HOT natural attribute of Zuojinwan and Fanzuojinwan based on temperature tropism of mice]. Yao Xue Xue Bao. 2010;45:791-6 pubmed
    ..the authenticity between COLD and HOT natural attribute in the famous Chinese medicine formulas--Zuojinwan (Coptis-Evodia 6 : 1) and Fanzuojinwan (Coptis-Evodia 1 : 6) based on mice temperature tropism, and establish an objective method ..