thalictrum

Summary

Summary: A plant genus of the family RANUNCULACEAE. Members contain isoquinoline alkaloids and triterpene glycosides.

Top Publications

  1. Serkedjieva J, Velcheva M. In vitro anti-influenza virus activity of the pavine alkaloid (-)-thalimonine isolated from Thalictrum simplex L. Antivir Chem Chemother. 2003;14:75-80 pubmed
    The pavine alkaloid (-)-thalimonine (Thl), isolated from the Mongolian plant Thalictrum simplex inhibited markedly the reproduction of influenza virus A/Germany/27, str. Weybridge (H7N7) and A/Germany/34, str...
  2. Wu W, Moyer M. API-ionspray MS and MS/MS study on the structural characterization of bisbenzylisoquinoline alkaloids. J Pharm Biomed Anal. 2004;34:53-66 pubmed
    ..links of two benzyltetrahydroisoquinoline units, which were isolated and identified previously from a variety of Thalictrum sp. (Ranunculaceae family)...
  3. Gao G, Chen S, Chen S, Wang L, Xiao P. Novel dimeric alkaloids from the roots of Thalictrum atriplex. J Asian Nat Prod Res. 2005;7:805-9 pubmed
    ..known dimeric alkaloids, thalifaberine, thalistine, and thalirecebine, have been isolated from the roots of Thalictrum atriplex Finet et Gagnep. Their structures have been established by spectroscopy...
  4. Di Stilio V, Martin C, Schulfer A, Connelly C. An ortholog of MIXTA-like2 controls epidermal cell shape in flowers of Thalictrum. New Phytol. 2009;183:718-28 pubmed publisher
    Here, we investigated the genetic underpinnings of pollination-related floral phenotypes in Thalictrum, a ranunculid with apetalous flowers...
  5. Ropivia J, Derbré S, Rouger C, Pagniez F, Le Pape P, Richomme P. Isoquinolines from the roots of Thalictrum flavum L. and their evaluation as antiparasitic compounds. Molecules. 2010;15:6476-84 pubmed publisher
    Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities...
  6. Terasaka K, Sakai K, Sato F, Yamamoto H, Yazaki K. Thalictrum minus cell cultures and ABC-like transporter. Phytochemistry. 2003;62:483-9 pubmed
    Cultured Thalictrum minus cells produce a benzylisoquinoline alkaloid, berberine, in the presence of benzyladenine, and excrete it into the culture medium. T...
  7. Khamidullina E, Gromova A, Lutsky V, Owen N. Natural products from medicinal plants: non-alkaloidal natural constituents of the Thalictrum species. Nat Prod Rep. 2006;23:117-29 pubmed
    b>Thalictrum is an important plant genus that is widely used in traditional medicine...
  8. Zhang X, Zhang L, Ye W, Zhang X, Yin Z, Zhao S, et al. Four new cycloartane glycosides from Thalictrum fortunei. Chem Pharm Bull (Tokyo). 2006;54:107-10 pubmed
    Four new cycloartane glycosides were isolated from the aerial parts of Thalictrum fortunei (Ranunculaceae)...
  9. Zhang X, Zhao M, Chen L, Jiao H, Liu H, Wang L, et al. A triterpenoid from Thalictrum fortunei induces apoptosis in BEL-7402 cells through the P53-induced apoptosis pathway. Molecules. 2011;16:9505-19 pubmed publisher
    b>Thalictrum fortunei S. Moore, a perennial plant distributed in the southeastern part of China, has been used in Traditional Chinese Medicine for thousands of years for its antitumor, antibacterial and immunoregulatory effects...

More Information

Publications52

  1. Berkner H, Engelhorn J, Liscombe D, Schweimer K, Wohrl B, Facchini P, et al. High-yield expression and purification of isotopically labeled norcoclaurine synthase, a Bet v 1-homologous enzyme, from Thalictrum flavum for NMR studies. Protein Expr Purif. 2007;56:197-204 pubmed
    The enzyme norcoclaurine synthase (NCS) found in the common meadow rue, Thalictrum flavum, and other plants shows sequence homology to members of the class 10 of pathogenesis related (PR 10) proteins that contains allergens such as the ..
  2. Liscombe D, Ziegler J, Schmidt J, Ammer C, Facchini P. Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species. Plant J. 2009;60:729-43 pubmed publisher
    ..for benzylisoquinoline alkaloid-producing cell cultures of Eschscholzia californica, Papaver bracteatum and Thalictrum flavum, and are a rich repository of alkaloid biosynthetic genes...
  3. Di Stilio V, Kumar R, Oddone A, Tolkin T, Salles P, McCarty K. Virus-induced gene silencing as a tool for comparative functional studies in Thalictrum. PLoS ONE. 2010;5:e12064 pubmed publisher
    Perennial woodland herbs in the genus Thalictrum exhibit high diversity of floral morphology, including four breeding and two pollination systems...
  4. Song Y, Wang Z, Zhang B, Zhang Y, Zhang W, Yang C, et al. Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study. J Pharm Biomed Anal. 2017;141:132-139 pubmed publisher
    Hernandezine, a novel anticancer AMPK activator, is a major active constituent of Thalictrum Ranunculaceae...
  5. Jiang S, Zhang Y, Xiao M, Jiang L, Luo D, Niu Q, et al. Cycloartane triterpenoid saponins from the herbs of Thalictrum fortunei. Carbohydr Res. 2017;445:1-6 pubmed publisher
    ..cycloartane triterpenoid saponins, thalisides A-F (1-6), along with four known ones (7-10), were isolated from Thalictrum fortunei. The new structures were elucidated by using spectroscopic data (NMR, IR, UV, and MS)...
  6. Mushtaq S, Rather M, Qazi P, Aga M, Shah A, Shah A, et al. Isolation and characterization of three benzylisoquinoline alkaloids from Thalictrum minus L. and their antibacterial activity against bovine mastitis. J Ethnopharmacol. 2016;193:221-226 pubmed publisher
    The roots of Thalictrum minus are traditionally used in the treatment of inflammation and infectious diseases such as bovine mastitis...
  7. Galimba K, Di Stilio V. Sub-functionalization to ovule development following duplication of a floral organ identity gene. Dev Biol. 2015;405:158-72 pubmed publisher
    ..The ranunculid Thalictrum thalictroides has two orthologs of the Arabidopsis thaliana C class gene AGAMOUS (AG), ThtAG1 and ThtAG2 (..
  8. Robin A, Giustini C, Graindorge M, Matringe M, Dumas R. Crystal structure of norcoclaurine-6-O-methyltransferase, a key rate-limiting step in the synthesis of benzylisoquinoline alkaloids. Plant J. 2016;87:641-53 pubmed publisher
    ..Four different crystal structures of the enzyme from Thalictrum flavum (Tf 6OMT) were solved: the apoenzyme, the complex with S-adenosyl-l-homocysteine (SAH), the complexe with ..
  9. Hao D, Ge G, Xiao P, Wang P, Yang L. Drug metabolism and pharmacokinetic diversity of ranunculaceae medicinal compounds. Curr Drug Metab. 2015;16:294-321 pubmed
    ..ADME/T) of Ranunculaceae compounds, there is a lack of DMPK studies of traditional medicinal genera Aquilegia, Thalictrum and Clematis...
  10. Frajman B, Carlón L, Kosachev P, Pedraja O, Schneeweiss G, Schönswetter P. Phylogenetic position and taxonomy of the enigmatic Orobanche krylowii (Orobanchaceae), a predominatly Asian species newly found in Albania (SE Europe). Phytotaxa. 2013;137: pubmed
    ..Both Orobanche krylowii and O. lycoctoni parasitize Ranunculaceae (Thalictrum spp. and Aconitum lycoctonum, respectively)...
  11. Torres M, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris J, et al. Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. J Biol Chem. 2016;291:23403-23415 pubmed
    ..To address this issue, the crystal structure of pavine NMT from Thalictrum flavum was solved using selenomethionine-substituted protein (dmin = 2.8 Å)...
  12. Soza V, Snelson C, Hewett Hazelton K, Di Stilio V. Partial redundancy and functional specialization of E-class SEPALLATA genes in an early-diverging eudicot. Dev Biol. 2016;419:143-155 pubmed publisher
    ..Our goal was to functionally characterize the E-class genes in the early-diverging eudicot Thalictrum thalictroides (Ranunculaceae), whose flowers are apetalous...
  13. Kumar A, Chowdhury S, Sarkar T, Chakrabarti T, Majumder H, Jha T, et al. A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani. Fitoterapia. 2016;109:25-30 pubmed publisher
    Chemical investigation of the stem of Thalictrum foliolosum resulted in the isolation of two new bisbenzylisoquinoline alkaloids (1 and 2) along with known protoberberine group of isoquinoline alkaloids thalifendine (3) and berberine (4)...
  14. Pandey G, Khatoon S, Pandey M, Rawat A. Altitudinal variation of berberine, total phenolics and flavonoid content in Thalictrum foliolosum and their correlation with antimicrobial and antioxidant activities. J Ayurveda Integr Med. 2018;9:169-176 pubmed publisher
    ..OBJECTIVE: We studied the variation in phytochemistry and biological activities of Thalictrum foliolosum (TF) roots collected from four sites at different altitudes...
  15. Li D, Li J, Xue C, Han T, Sai C, Wang K, et al. Antiproliferative Dimeric Aporphinoid Alkaloids from the Roots of Thalictrum cultratum. J Nat Prod. 2017;80:2893-2904 pubmed publisher
    ..alkaloid, thalicultratine L, and five known ones were isolated from the roots of Thalictrum cultratum. Their structures were defined on the basis of NMR and HRESIMS data...
  16. Wu W, Moyer M. Electrospray tandem mass spectrometry for structural characterization of aporphine- benzylisoquinoline alkaloids. Eur J Mass Spectrom (Chichester). 2004;10:683-9 pubmed
    ..and benzyltetrahydroisoquinoline units, which were isolated and identified previously from a variety of Thalictrum sp...
  17. Mayeku P, Hassanali A, Kiremire B, Odalo J, Hertweck C. Anti-bacterial activities and phytochemical screening of extracts of different parts of Thalictrum rhynchocarpum. Afr J Tradit Complement Altern Med. 2013;10:341-4 pubmed
    Parts of the plant Thalictrum rhyncocarpum are used in herbal medicine in Kenya to treat various infections...
  18. Li D, Guo J, Bin W, Zhao N, Wang K, Li J, et al. Two new benzylisoquinoline alkaloids from Thalictrum foliolosum and their antioxidant and in vitro antiproliferative properties. Arch Pharm Res. 2016;39:871-7 pubmed publisher
    ..A (1) and B (2), along with eight known isoquinoline alkaloids (3-10) were isolated from the whole plant of Thalictrum foliolosum...
  19. Ilari A, Franceschini S, Bonamore A, Arenghi F, Botta B, Macone A, et al. Structural basis of enzymatic (S)-norcoclaurine biosynthesis. J Biol Chem. 2009;284:897-904 pubmed publisher
    ..The crystallographic structure of norcoclaurine synthase from Thalictrum flavum in its complex with dopamine substrate and the nonreactive substrate analogue 4-hydroxybenzaldehyde has ..
  20. Miller K, Gorchov D. The invasive shrub, Lonicera maackii, reduces growth and fecundity of perennial forest herbs. Oecologia. 2004;139:359-75 pubmed
    ..North American forests, on survival, growth, and reproduction of three perennial herbs: Allium burdickii, Thalictrum thalictroides , and Viola pubescens. We predicted that the spring ephemeral, A...
  21. Horvath L, Konstantinov S, Ilarionova M, Todorov D. Effects of the plant alkaloid thaliblastine on non-cross-resistant and sensitive human leukemia cells in relation with reversal of acquired anthracycline resistance. Fitoterapia. 2004;75:712-7 pubmed
    ..Additionally, typical for apoptosis oligonucleosomal DNA fragmentation could be detected in leukemia cells treated with thaliblastine. Moreover, an MDR-phenotype reversing effect of thaliblastine was also identified...
  22. Samanani N, Park S, Facchini P. Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis. Plant Cell. 2005;17:915-26 pubmed
    ..catalyze the conversion of l-dopa to the protoberberine alkaloid (S)-canadine were isolated from meadow rue (Thalictrum flavum ssp glaucum)...
  23. Tian Z, Xiao P, Wen J, Huang F, Yang M, Chen S. [Review of bioactivities of natural cycloartane triterpenoids]. Zhongguo Zhong Yao Za Zhi. 2006;31:625-9 pubmed
    ..This will be benefit for the further research and development of the compounds...
  24. Taherpour A, Maroofi H. Chemical composition of the essential oil of Thalectrum minus L. of Iran. Nat Prod Res. 2008;22:97-100 pubmed
    The volatile constituents of the essential oil of Thalictrum minus L. growing wild in Kurdistan-Iran were investigated by GC and GC / MS technique. Twelve compounds, representing 100% of the total oil were identified...
  25. Zhang X, Ma S, Jiao H, Zhang Q. Two new saponins from Thalictrum fortunei. J Asian Nat Prod Res. 2012;14:327-32 pubmed publisher
    Two new cycloartane glycosides were isolated from the aerial parts of Thalictrum fortunei (Ranunculaceae)...
  26. Cheng H, Zeng Y, Jia B, Fang C, Cheng W. Screening and identification of various components in Thalictrum fortunei using a combination of liquid chromatography/time-of-flight tandem mass spectrometry. Pharmazie. 2012;67:106-10 pubmed
    ..The chemical profile of Thalictrum fortunei, well-known in TCM, was studied using the established method...
  27. Zhang X, Wang L, Ma S, Zhang Q, Liu Y, Zhang L, et al. New cycloartane glycosides from the aerial part of Thalictrum fortunei. J Nat Med. 2013;67:375-80 pubmed publisher
    ..25-O-?-D-glucopyranosyl-(1 ? 4)-?-D-glucopyranoside (4), were isolated from the aerial parts of Thalictrum fortunei...
  28. Soza V, Brunet J, Liston A, Smith P, Di Stilio V. Phylogenetic insights into the correlates of dioecy in meadow-rues (Thalictrum, Ranunculaceae). Mol Phylogenet Evol. 2012;63:180-92 pubmed publisher
    ..b>Thalictrum, meadow-rues (Ranunculaceae), provides a unique opportunity to study the evolution of these traits because it ..
  29. Torrens Spence M, Gillaspy G, Zhao B, Harich K, White R, Li J. Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme. Biochem Biophys Res Commun. 2012;418:211-6 pubmed publisher
    ..This is the first reported case of an AAS enzyme utilizing tyrosine as a primary substrate and the first report of a single enzyme capable of producing 4-HPAA from tyrosine...
  30. Pasquo A, Bonamore A, Franceschini S, Macone A, Boffi A, Ilari A. Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from Thalictrum flavum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:281-3 pubmed publisher
    ..31, c = 118.36 A. A selenomethionine derivative was overexpressed, purified and crystallized in the same space group. A complete MAD data set was collected at 2.7 A resolution. The model is under construction...
  31. Chen S, Chen S, Xiao P. Ethnopharmacological investigations on Thalictrum plants in China. J Asian Nat Prod Res. 2003;5:263-71 pubmed
    b>Thalictrum (Ranunculaceae) is an extremely abundant medicinal plant source...
  32. Lee E, Facchini P. Norcoclaurine synthase is a member of the pathogenesis-related 10/Bet v1 protein family. Plant Cell. 2010;22:3489-503 pubmed publisher
    ..NCS from Thalictrum flavum (Tf NCS), Papaver somniferum (Ps NCS1 and Ps NCS2), and Coptis japonica (Cj PR10A) share substantial ..
  33. Terasaka K, Shitan N, Sato F, Maniwa F, Ueda K, Yazaki K. Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins. Plant Cell Physiol. 2003;44:198-200 pubmed
    ..mammalian ATP-binding cassette (ABC) proteins, was applied to berberine-producing plant cell cultures, Thalictrum minus and Coptis japonica. One membrane protein at ca...
  34. Lichman B, Sula A, Pesnot T, Hailes H, Ward J, Keep N. Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase. Biochemistry. 2017;56:5274-5277 pubmed publisher
    ..Here we present new high-resolution X-ray crystallography data describing Thalictrum flavum NCS bound to a mechanism-inspired ligand...
  35. Serkedjieva J, Velcheva M. In vitro anti-influenza virus activity of isoquinoline alkaloids from thalictrum species. Planta Med. 2003;69:153-4 pubmed
    The in vitro anti-influenza virus effects of some isoquinoline alkaloids, isolated from Thalictrum species (Ranunculaceae), growing in Mongolia and Sweden have been studied...
  36. Gao G, Chen S, Wang L, Liao M, Yu S, Xiao P. [Studies on chemical constituents of Thalictrum atriplex Finet et Gagnep]. Zhongguo Zhong Yao Za Zhi. 1999;24:160-1, 191 pubmed
    To study the chemical constituents in the aerial part of Thalictrum atriplex.
  37. Samanani N, Liscombe D, Facchini P. Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis. Plant J. 2004;40:302-13 pubmed
    ..A molecular clone encoding NCS was isolated from a meadow rue (Thalictrum flavum ssp. glaucum) cell suspension culture cDNA library...
  38. Das N, Rabha B, Talukdar P, Goswami D, Dhiman S. Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum. BMC Res Notes. 2016;9:51 pubmed publisher
    ..The present study involves in vitro evaluation of two medicinally important plants Aristolochia griffithii and Thalictrum foliolosum DC used in antimalarial chemotherapy by the tribes of northeast India...
  39. Luk L, Bunn S, Liscombe D, Facchini P, Tanner M. Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction. Biochemistry. 2007;46:10153-61 pubmed
    ..In this work, the gene encoding for the Thalictrum flavum norcoclaurine synthase is highly overexpressed in Escherichia coli and the resulting His-tagged ..
  40. Soza V, Haworth K, Di Stilio V. Timing and consequences of recurrent polyploidy in meadow-rues (thalictrum, ranunculaceae). Mol Biol Evol. 2013;30:1940-54 pubmed publisher
    ..Here, we take a molecular systematics approach to examine the evolution of polyploidy in the plant genus Thalictrum (Ranunculaceae) and test its correlation to changes in genome size, sexual system, and pollination mode...
  41. Galimba K, Tolkin T, Sullivan A, Melzer R, Theißen G, Di Stilio V. Loss of deeply conserved C-class floral homeotic gene function and C- and E-class protein interaction in a double-flowered ranunculid mutant. Proc Natl Acad Sci U S A. 2012;109:E2267-75 pubmed publisher
    ..We conduct a functional analysis of the putative AG ortholog ThtAG1 from the ranunculid Thalictrum thalictroides, a representative of the sister lineage to all other eudicots...
  42. Samanani N, Facchini P. Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants. J Biol Chem. 2002;277:33878-83 pubmed
    ..NCS was purified 1590-fold to homogeneity from cell suspension cultures of meadow rue (Thalictrum flavum ssp. glaucum). The purification procedure, which resulted in a 4...
  43. Jain A, Ziegler J, Liscombe D, Facchini P, Tucker P, Panjikar S. Purification, crystallization and X-ray diffraction analysis of pavine N-methyltransferase from Thalictrum flavum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:1066-9 pubmed publisher
    A cDNA from the plant Thalictrum flavum encoding pavine N-methyltransferase, an enzyme belonging to a novel class of S-adenosylmethionine-dependent N-methyltransferases specific for benzylisoquinoline alkaloids, has been heterologously ..