nigella sativa

Summary

Summary: A plant genus of the family RANUNCULACEAE that contains alpha-hederin, a triterpene saponin in the seeds, and is the source of black seed oil.

Top Publications

  1. Ali B, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003;17:299-305 pubmed
    The seeds of Nigella sativa Linn...
  2. Kaleem M, Kirmani D, Asif M, Ahmed Q, Bano B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp Biol. 2006;44:745-8 pubmed
    ..The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats...
  3. Harzallah H, Grayaa R, Kharoubi W, Maaloul A, Hammami M, Mahjoub T. Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis. Oxid Med Cell Longev. 2012;2012:854065 pubmed publisher
    We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon ..
  4. El Shenawy N, Soliman M, Reyad S. The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Rev Inst Med Trop Sao Paulo. 2008;50:29-36 pubmed
    ..of this study was to assess the antioxidant and anti-schistosomal activities of the garlic extract (AGE) and Nigella sativa oil (NSO) on normal and Schistosoma mansoni-infected mice. AGE (125 mg kg-1, i.p.) and NSO (0.2 mg kg-1, i.p...
  5. Mehta B, Mehta P, Gupta M. A new naturally acetylated triterpene saponin from Nigella sativa. Carbohydr Res. 2009;344:149-51 pubmed publisher
    ..hederagenin from an ethanolic extract of seeds of Nigella sativa Linn...
  6. Yildiz F, Coban S, Terzi A, Ates M, Aksoy N, Cakir H, et al. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World J Gastroenterol. 2008;14:5204-9 pubmed
    To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sativa (NS) treatment group (Group 3)...
  7. Hossein B, Nasim V, Sediqa A. The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed Guinea pigs. Exp Lung Res. 2008;34:183-94 pubmed publisher
    ..However, the protective effect of Nigella sativa on inflammatory process was shown...
  8. Abu El Ezz N. Effect of Nigella sativa and Allium cepa oils on Trichinella spiralis in experimentally infected rats. J Egypt Soc Parasitol. 2005;35:511-23 pubmed
    ..sativa oil. In conclusion, N. sativa and A. cepa oils have anthelmintic effect in the rats infected with T. spiralis infection and increased the production of antibodies generated during life cycle of this parasite. ..
  9. Boskabady M, Shirmohammadi B, Jandaghi P, Kiani S. Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. BMC Pharmacol. 2004;4:3 pubmed
    In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains...

More Information

Publications94

  1. Yildiz F, Coban S, Terzi A, Savas M, Bitiren M, Celik H, et al. Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys. Ren Fail. 2010;32:126-31 pubmed publisher
    ..The protective effects of Nigella sativa against ischemia-perfusion damage to various organs have been previously documented...
  2. Al Ali A, Alkhawajah A, Randhawa M, Shaikh N. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad. 2008;20:25-7 pubmed
    Thymoquinone is the major active principle of Nigella sativa (N. sativa) and constitutes about 30% of its volatile oil or ether extract. N. sativa oil and seed are commonly used as a natural remedy for many ailments...
  3. Balaha M, Tanaka H, Yamashita H, Abdel Rahman M, Inagaki N. Oral Nigella sativa oil ameliorates ovalbumin-induced bronchial asthma in mice. Int Immunopharmacol. 2012;14:224-31 pubmed publisher
    b>Nigella sativa oil (NSO) is used in folk medicine as a therapy for many diseases including bronchial asthma. We investigated the possible modulating effects of NSO on asthma-like phenotypes in a mouse model of bronchial asthma...
  4. Kocyigit Y, Atamer Y, Uysal E. The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. Saudi Med J. 2009;30:893-6 pubmed
    To investigate the effect of oral treatment of Wistar albino rats with different doses of Nigella sativa L. (NS) powdered seeds on the levels of serum lipids...
  5. Hadjzadeh M, Khoei A, Hadjzadeh Z, Parizady M. Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats. Urol J. 2007;4:86-90 pubmed
    The aim of this study was to investigate the effects of the ethanolic extract of Nigella sativa L (NS) seeds on kidney calculi in rats...
  6. Kanter M. Protective effects of Nigella sativa on the neuronal injury in frontal cortex and brain stem after chronic toluene exposure. Neurochem Res. 2008;33:2241-9 pubmed publisher
    The goal of this study was designed to evaluate the possible protective effects of Nigella sativa (NS) on the neuronal injury in the frontal cortex and brain stem after chronic toluene exposure in rats...
  7. El Saleh S, Al Sagair O, Al Khalaf M. Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. Int J Cardiol. 2004;93:19-23 pubmed
    ..Here we show that active antioxidant components of the traditionally used black seeds of Nigella sativa plant protect against the development of methionine-induced HHcy and its associated state of oxidative stress...
  8. Dehkordi F, Kamkhah A. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008;22:447-52 pubmed publisher
    ..a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of treatment with an oral Nigella sativa (NS) seed extract supplement in patients with mild HT...
  9. Velho Pereira R, Barhate C, Kulkarni S, Jagtap A. Validated high-performance thin-layer chromatographic method for the quantification of thymoquinone in Nigella Sativa extracts and formulations. Phytochem Anal. 2011;22:367-73 pubmed publisher
    ..molecules, one of them being thymoquinone (TQ) the bioactive constituent of the volatile oil of black seed, Nigella sativa L. (NS)...
  10. Salem M, Alenzi F, Attia W. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro. Br J Biomed Sci. 2011;68:131-7 pubmed
    ..Based on recent studies showing in vivo antioxidant effects of thymoquinone (TQ), the active ingredient of Nigella sativa seeds, this study aims to determine whether or not TQ can increase survival and sustain the expression of the ..
  11. Rooney S, Ryan M. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res. 2005;25:2199-204 pubmed
    The separate effects of alpha-hederin and thymoquinone, the two principal bioactive constituents of Nigella sativa, on four human cancer cell lines [A549 (lung carcinoma), HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) ..
  12. Sultan M, Butt M, Ahmad R, Pasha I, Ahmad A, Qayyum M. Supplementation of Nigella sativa fixed and essential oil mediates potassium bromate induced oxidative stress and multiple organ toxicity. Pak J Pharm Sci. 2012;25:175-81 pubmed
    ..The present research was designed study the health promoting potential of black cumin (Nigella sativa) fixed oil (BCFO) and essential oil (BCEO) against oxidative stress with special reference to multiple organ ..
  13. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res. 2004;18:195-9 pubmed
    The steam-distilled essential oil of Iranian black cumin seed (Nigella sativa L.) was investigated for its composition and analgesic and antiinflammatory properties...
  14. Ibrahim Z, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, et al. Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 2008;56:119-28 pubmed
    b>Nigella sativa (family Ranunculaceae) is an annual plant that has been traditionally used on the Indian subcontinent and in Middle Eastern countries. In this study, we investigated the effect of N...
  15. Farah I, Begum R. Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomed Sci Instrum. 2003;39:359-64 pubmed
    ..Sativa alone or in combination with oxidative stress were found to be effective in vitro in inactivating MCF-7 breast cancer cells, unveiling opportunities for promising results in the field of prevention and treatment of cancer...
  16. Al Ghamdi M. Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage. Am J Chin Med. 2003;31:721-8 pubmed
    It has been reported that Nigella sativa oil possesses hepatoprotective effects in some models of liver toxicity. However, it is N. sativa seeds that are used in the treatment of liver ailments in folk medicine rather than its oil...
  17. Kanter M, Meral I, Dede S, Gunduz H, Cemek M, Ozbek H, et al. Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats. J Vet Med A Physiol Pathol Clin Med. 2003;50:264-8 pubmed
    This study was designed to investigate the effects Nigella sativa L. (NS) and Urtica dioica L. (UD) on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in carbon tetrachloride (CCl4)-treated rats...
  18. Kanter M. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res. 2008;33:87-96 pubmed
    The aim of this study was designed to investigate the possible beneficial effects of Nigella sativa (NS) and thymoquinone (TQ) on histopathological changes of sciatic nerves in streptozotocin-induced diabetic rats...
  19. Işik H, Cevikbaş A, Gurer U, Kiran B, Uresin Y, Rayaman P, et al. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract. 2010;19:206-11 pubmed publisher
    To investigate the effects of Nigella sativa seed supplementation on symptom levels, polymorphonuclear leukocyte (PMN) functions, lymphocyte subsets and hematological parameters of allergic rhinitis...
  20. Sayed Ahmed M, Nagi M. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol. 2007;34:399-405 pubmed
    1. The present study investigated the possible protective effects of thymoquinone (TQ), a compound derived from Nigella sativa with strong anti-oxidant properties, against gentamicin (GM)-induced nephrotoxicity. 2...
  21. Alkharfy K, Al Daghri N, Al Attas O, Alokail M. The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice. Int Immunopharmacol. 2011;11:250-4 pubmed publisher
    ..Thymoquinone, a constituent of Nigella sativa (black seed), holds exceptional promise as an anti-cancer and anti-inflammatory agent...
  22. Türkdoğan M, Ozbek H, Yener Z, Tuncer I, Uygan I, Ceylan E. The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride-induced hepatotoxicity in rats. Phytother Res. 2003;17:942-6 pubmed
    The role of Nigella sativa L. (Ranunculaceae) (NS) and Urtica dioica L. was investigated (UD) in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis and cirrhosis...
  23. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004;11:56-64 pubmed
    The anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, were investigated using pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizure models...
  24. Al Johar D, Shinwari N, Arif J, Al Sanea N, Jabbar A, El Sayed R, et al. Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats. Phytother Res. 2008;22:1311-23 pubmed publisher
    This study examined the chemopreventive effect of Nigella sativa and some of its antioxidant constituents on a number of colon cancer biomarkers in rats induced with azoxymethane (AOM)...
  25. Qidwai W, Hamza H, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med. 2009;15:639-44 pubmed publisher
    The seed extracts from Nigella sativa is used by Unani physicians of traditional medicine (Hakims or Tabibs) and Ayurvedic practitioners (Vaids) in the treatment of several medical disorders including dyslipidemia, obesity, and ..
  26. Boskabady M, Vahedi N, Amery S, Khakzad M. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J Ethnopharmacol. 2011;137:1028-34 pubmed publisher
    ETHNOMEDICAL RELEVANCE: The anti-inflammatory activity of both systemic and local administrations of essential oil from Nigella sativa L. has been shown.
  27. Hasan T, Shafi G, Syed N, Alfawaz M, Alsaif M, Munshi A, et al. Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis. Nat Prod Commun. 2013;8:213-6 pubmed
    b>Nigella sativa (NS), also known as black cumin, has long been used in traditional medicine for treating various cancer conditions...
  28. Ramadan M, Mörsel J. Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil. Nahrung. 2002;46:240-4 pubmed
    Black cumin (Nigella sativa L.) seed oil was extracted with two different solvents, n-hexane (H) and a mixture of chloroform/methanol (CM) (2:1, by volume). Amount of total lipid (TL) was higher in the CM miscelle (39...
  29. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius J, et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 2003;17:1209-14 pubmed
    b>Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies...
  30. Kanter M, Meral I, Yener Z, Ozbek H, Demir H. Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J Exp Med. 2003;201:213-9 pubmed
    ..More studies are needed to demonstrate the exact mechanism of action of N. sativa L. on ameliorated blood glucose concentration in STZ-induced diabetes...
  31. Salim E, Fukushima S. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer. 2003;45:195-202 pubmed
    Chemopreventive effects of orally administered Nigella sativa oil on the induction and development of 1,2-dimethylhydrazine-induced aberrant crypt foci (ACF), putative preneoplastic lesions for colon cancer, were investigated in Fischer ..
  32. Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med. 2005;71:739-42 pubmed
    ..sativa and suggest that these agents should be further studied for possible use as non-steroidal anti-inflammatory drugs...
  33. Altan M, Kanter M, Donmez S, Kartal M, Buyukbas S. Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats. Acta Histochem. 2007;109:304-14 pubmed
    Extracts of the seeds of Nigella sativa (NS), an annual herbaceous plant of the Ranunculaceae family, have been used for many years for therapeutic purposes, including their potential anti-diabetic properties...
  34. Lupidi G, Scire A, Camaioni E, Khalife K, De Sanctis G, Tanfani F, et al. Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin. Phytomedicine. 2010;17:714-20 pubmed publisher
    Thymoquinone (TQ) is the main constituent of Nigella sativa essential oil which shows promising in vitro and in vivo antineoplastic growth inhibition against various tumor cell lines...
  35. Gheita T, Kenawy S. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012;26:1246-8 pubmed publisher
    The constituents of Nigella sativa modulate the immune system. The aim of the present work was to study the effectiveness of Nigella sativa oil in RA patients...
  36. Khan N, Sultana S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Eur J Cancer Prev. 2005;14:159-68 pubmed
    In an earlier communication we reported that Nigella sativa suppresses potassium bromate-induced renal oxidative damage...
  37. Noor N, Aboul Ezz H, Faraag A, Khadrawy Y. Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. Epilepsy Behav. 2012;24:199-206 pubmed publisher
    The present study aimed to investigate the effect of curcumin and Nigella sativa oil (NSO) on amino acid neurotransmitter alterations and the histological changes induced by pilocarpine in the hippocampus and cortex of rats...
  38. Bourgou S, Ksouri R, Bellila A, Skandrani I, Falleh H, Marzouk B. Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots. C R Biol. 2008;331:48-55 pubmed publisher
    In the present investigation, methanolic extracts from shoots and roots of Tunisian Nigella sativa were assayed for their antioxidant and antimutagenic activities...
  39. Abdel Zaher A, Abdel Rahman M, ELwasei F. Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice. Neurochem Res. 2010;35:1557-65 pubmed publisher
    The effects of Nigella sativa oil on morphine-induced tolerance and dependence in mice and possible mechanism(s) of these effects were investigated, for the first time, in this study...
  40. Assayed M. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Immunopharmacol Immunotoxicol. 2010;32:284-96 pubmed publisher
    ..Wistar rats, divided into 4 groups, 15 each, were designed as I-control rats, II-rats orally intubated with Nigella sativa oil (1 ml/kg b.wt...
  41. Isik F, Tunali Akbay T, Yarat A, Genc Z, Pisiriciler R, Caliskan Ak E, et al. Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig Dis Sci. 2011;56:721-30 pubmed publisher
    The pathogenesis and treatment of ulcerative colitis remain poorly understood. The aim of the present study is to investigate the effects of black cumin (Nigella sativa) oil on rats with colitis.
  42. Abbas A, Abdel Aziz M, Zalata K, Abd Al Galel T. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol. 2005;12:95-102 pubmed
    It has been reported that Nigella sativa oil possesses anti-inflammatory and bronchodilator activities. Besides, non - toxic and wide margin of safety for therapeutic doses compared with Dexamethasone...
  43. Khan M, Ashfaq M, Zuberi H, Mahmood M, Gilani A. The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytother Res. 2003;17:183-6 pubmed
    The effect of an aqueous extract of Nigella sativa seeds was studied on candidiasis in mice. An intravenous inoculum of Candida albicans produced colonies of the organism in the liver, spleen and kidneys...
  44. Botnick I, Xue W, Bar E, Ibdah M, Schwartz A, Joel D, et al. Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. Molecules. 2012;17:10159-77 pubmed publisher
    Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance...
  45. Mahmmoud Y, Christensen S. Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. Biochim Biophys Acta. 2011;1808:2413-20 pubmed publisher
    b>Nigella sativa seed oil was found to contain a modulator of Na,K-ATPase. Separation analyses combined with (1)H NMR and GCMS identified the inhibitory fraction as a mixture of oleic and linoleic acids...
  46. Tripathi Y, Chaturvedi A, Pandey N. Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug. Indian J Exp Biol. 2012;50:413-8 pubmed
    ..Its mechanism of action was proposed primarily through its antioxidant potential and not through direct inhibition of other kinases, involved in its signaling cascade...
  47. Boskabady M, Keyhanmanesh R, Khamneh S, Ebrahimi M. The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs. Clinics (Sao Paulo). 2011;66:879-87 pubmed
    To examine the preventive effect of a hydro-ethanolic extract of Nigella sativa on the tracheal responsiveness and white blood cell count in the lung lavage fluid of sensitized guinea pigs.
  48. Randhawa M, Alghamdi M. Anticancer activity of Nigella sativa (black seed) - a review. Am J Chin Med. 2011;39:1075-91 pubmed
    b>Nigella sativa (N. sativa) seed has been an important nutritional flavoring agent and natural remedy for many ailments for centuries in ancient systems of medicine, e.g. Unani, Ayurveda, Chinese and Arabic Medicines...
  49. Yaman I, Balikci E. Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats. Exp Toxicol Pathol. 2010;62:183-90 pubmed publisher
    ..In conclusion, NS acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GS both in the biochemical and histopathological parameters...
  50. Nagi M, Almakki H. Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity. Phytother Res. 2009;23:1295-8 pubmed publisher
    Thymoquinone (TQ), the main constituents of the volatile oil from Nigella sativa seeds is reported to protect laboratory animals against chemical carcinogenesis and toxicity through mechanism(s) that is not fully understood...
  51. Boskabady M, Farhadi J. The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14:1137-44 pubmed publisher
    ..relaxant, anticholinergic (functional antagonism), and antihistaminic effects of various extracts and oils of Nigella sativa seed have been demonstrated...
  52. Ng W, Yazan L, Ismail M. Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein. Toxicol In Vitro. 2011;25:1392-8 pubmed publisher
    Thymoquinone (TQ), the active constituent of Nigella sativa or black cumin exhibited cytotoxic effects in several cancer cell lines. In this study, the cytotoxicity of TQ in human cervical squamous carcinoma cells (SiHa) was investigated...
  53. Butt M, Sultan M. Nigella sativa: reduces the risk of various maladies. Crit Rev Food Sci Nutr. 2010;50:654-65 pubmed publisher
    ..Numerous plants have been tested for their therapeutic potential; Nigella sativa, commonly known as black cumin, is one of them...
  54. Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I. Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods. J Food Prot. 2008;71:2475-80 pubmed
    b>Nigella sativa L...
  55. Terzi A, Coban S, Yildiz F, Ates M, Bitiren M, Taskin A, et al. Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats. J Invest Surg. 2010;23:21-7 pubmed publisher
    In previous studies, it has been demonstrated that Nigella Sativa (NS) has protective effects against ischemia reperfusion injury on various organs...
  56. Al Naggar T, Gómez Serranillos M, Carretero M, Villar A. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88:63-8 pubmed
    Pharmacological studies have been conducted on the aqueous and methanol extracts of defatted Nigella sativa L. seeds to evaluate their effects on the central nervous system (CNS) and on analgesic activity...
  57. Kanter M, Akpolat M, Aktas C. Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. J Mol Histol. 2009;40:379-85 pubmed publisher
    The aim of this study was to evaluate the possible protective effects of the volatile oil of Nigella sativa (NS) seeds on insulin immunoreactivity and ultrastructural changes of pancreatic beta-cells in STZ-induced diabetic rats...
  58. Boskabady M, Keyhanmanesh R, Saadatloo M. Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s). Indian J Exp Biol. 2008;46:805-10 pubmed
    ..The results showed relaxant effect of most fractions from N. sativa on tracheal chains of guinea pigs which was more potent for methanol and dichloromethane fractions...
  59. Barakat E, El Wakeel L, Hagag R. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 2013;19:2529-36 pubmed publisher
    To evaluate the safety, efficacy and tolerability of Nigella sativa (N. sativa) in patients with hepatitis C not eligible for interferon (IFN)-?.
  60. Abdel Wahhab M, Aly S. Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. J Appl Toxicol. 2005;25:218-23 pubmed
    ..b>Nigella sativa (black cumin) and Syzygium aromaticum (clove) oil are used for the treatment of inflammatory diseases and have ..
  61. Ghannadi A, Hajhashemi V, Jafarabadi H. An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. J Med Food. 2005;8:488-93 pubmed
    Extracts obtained from the seeds of Nigella sativa are used as a spice or remedy for the treatment of various inflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphenols...
  62. Keyhanmanesh R, Boskabady M, Eslamizadeh M, Khamneh S, Ebrahimi M. The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs. Planta Med. 2010;76:218-22 pubmed publisher
    In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic, effects of Nigella sativa have been demonstrated on guinea pig tracheal chains...
  63. Boskabady M, Keyhanmanesh R, Khameneh S, Doostdar Y, Khakzad M. Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs. J Zhejiang Univ Sci B. 2011;12:201-9 pubmed publisher
    Several different pharmacological effects have been described for Nigella sativa (Siah-Daneh), including an anti-inflammatory effect. In the present study, the effect of the extract of N...
  64. Alenzi F, El Bolkiny Y, Salem M. Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. Br J Biomed Sci. 2010;67:20-8 pubmed
    Constituents of the Nigella sativa seed are reported to possess potent antioxidant effects...
  65. Aljabre S, Randhawa M, Akhtar N, Alakloby O, Alqurashi A, Aldossary A. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. J Ethnopharmacol. 2005;101:116-9 pubmed
    The antifungal activity of ether extract of Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of Trichophyton rubrum and one each of Trichophyton interdigitale, ..
  66. Boskabady M, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol. 2007;21:559-66 pubmed
    In previous studies, the relaxant, anticholinergic (functional antagonism) antihistaminic, effects of Nigella sativa have been demonstrated on guinea-pig tracheal chains...
  67. Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation. BMC Complement Altern Med. 2011;11:29 pubmed publisher
    Thymoquinone is an active principle of Nigella sativa seed known as "Habbah Al-Sauda" in Arabic countries and "Sinouj" in Tunisia. Bacterial biofilms tend to exhibit significant tolerance to antimicrobials drugs during infections...
  68. Korany N, Ezzat B. Prophylactic effect of green tea and Nigella sativa extracts against fenitrothion-induced toxicity in rat parotid gland. Arch Oral Biol. 2011;56:1339-46 pubmed publisher
    ..The aim of the present study was to compare between two antioxidant treatments in prevention of fenitrothion induced toxicity on rat parotid salivary gland...
  69. Kacem R, Meraihi Z. The effect of essential oil extracted from Nigella sativa (L.) seeds on human neutrophil functions. Nat Prod Res. 2009;23:1168-75 pubmed publisher
    ..The observed inhibition of neutrophil functions occurred via intracellular pathway. Active serine protease could be essential for neutrophil responding process and/or signal transduction pathways...
  70. Rogozhin E, Oshchepkova Y, Odintsova T, Khadeeva N, Veshkurova O, Egorov T, et al. Novel antifungal defensins from Nigella sativa L. seeds. Plant Physiol Biochem. 2011;49:131-7 pubmed publisher
    From seeds of Nigella sativa L. (Ranunculaceae), an endemic plant of Uzbekistan, two novel defensins named Ns-D1 and Ns-D2, were isolated and sequenced...
  71. Salem M. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5:1749-70 pubmed
    ..Seeds of Nigella sativa, a dicotyledon of the Ranunculaceae family, have been employed for thousands of years as a spice and food ..
  72. Boskabady M, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010;17:707-13 pubmed publisher
    In the present study, the antiasthmatic (bronchodilatory) effect of the boiled extract of Nigella sativa in the airways of asthmatic patients was examined...
  73. El Ghamery A, el Kholy M, Abou El Yousser M. Evaluation of cytological effects of Zn2+ in relation to germination and root growth of Nigella sativa L. and Triticum aestivum L. Mutat Res. 2003;537:29-41 pubmed
    The effects of different treatments with zinc sulfate (Zn(2+)) on the cytology and growth of Nigella sativa and Triticum aestivum were investigated...
  74. Le P, Benhaddou Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad P. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol. 2004;94:251-9 pubmed
    We studied the effect of a 4-week intragastric gavage with a petroleum ether extract of Nigella sativa seeds on blood glucose, insulin and lipids in the normal rat...
  75. Rastogi L, Feroz S, Pandey B, Jagtap A, Mishra K. Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L. Int J Radiat Biol. 2010;86:719-31 pubmed publisher
    An ethanolic extract of Nigella sativa L. (EE-NS) was investigated for its antioxidant properties and radioprotective effects against gamma-radiation-induced oxidative damage.
  76. Bakathir H, Abbas N. Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Complement Altern Med. 2011;8:159-64 pubmed
    b>Nigella sativa (NS) seeds have been used for medicinal purposes for centuries both as herbs and its oil. In Islam it is regarded as one of the greatest forms of healing medicine included in the medicine of prophet Mohammed...
  77. Dahri A, Chandiol A, Rahoo A, Memon R. Effect of Nigella sativa (kalonji) on serum cholesterol of albino rats. J Ayub Med Coll Abbottabad. 2005;17:72-4 pubmed
    ..The effect of Nigella sativa on levels of cholesterol fractions were determined in this study on rats.
  78. Hadjzadeh M, Keshavarzi Z, Tabatabaee Yazdi S, Ghasem Shirazi M, Rajaei Z, Khajavi Rad A. Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat. Iran J Kidney Dis. 2012;6:99-104 pubmed
    The aim of this study was to test whether Nigella sativa (NS) seeds can reduce cisplatin-induced toxicity.
  79. Coban S, Yildiz F, Terzi A, Al B, Aksoy N, Bitiren M, et al. The effects of Nigella sativa on bile duct ligation induced-liver injury in rats. Cell Biochem Funct. 2010;28:83-8 pubmed publisher
    b>Nigella sativa (NS) has been shown to have antioxidant and antiinflammatory activities in different conditions. The goal of this study was to evaluate the effects of NS on cholestatic liver injury in rats...
  80. Hosseinzadeh H, Parvardeh S, Asl M, Sadeghnia H, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine. 2007;14:621-7 pubmed
    It has been previously reported that Nigella sativa oil (NSO) and thymoquinone (TQ), active constituent of N. sativa seeds oil, may prevent oxidative injury in various models...
  81. Kanter M. Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem Res. 2008;33:579-88 pubmed
    The aim of this study was designed to investigate the possible beneficial effects of Nigella sativa (NS) and derived thymoquinone (TQ) on neurodegeneration in hippocampus after chronic toluene exposure in rats...
  82. Kanter M, Coskun O, Korkmaz A, Oter S. Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. Anat Rec A Discov Mol Cell Evol Biol. 2004;279:685-91 pubmed
    The aim of the present study was to evaluate the possible protective effects of Nigella sativa L. (NS) against beta-cell damage from streptozotocin (STZ)-induced diabetes in rats...
  83. Amin S, Mir S, Kohli K, Ali B, Ali M. A study of the chemical composition of black cumin oil and its effect on penetration enhancement from transdermal formulations. Nat Prod Res. 2010;24:1151-7 pubmed publisher
    The chemical composition of the solvent extracted fixed oil of black cumin (Nigella sativa L.) seeds was determined by capillary GC and GC/MS. Thirty-two fatty acids (99.9%) have been identified in the fixed oil...
  84. Farrag A, Mahdy K, Abdel Rahman G, Osfor M. Protective effect of Nigella sativa seeds against lead-induced hepatorenal damage in male rats. Pak J Biol Sci. 2007;10:2809-16 pubmed
    ..The present study was carried out to investigate the possible protective effect of co-administered Nigella sativa seeds on lead acetate-induced rats' toxicity in particularly on liver and kidney...
  85. Ezz H, Khadrawy Y, Noor N. The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. Neurochem Res. 2011;36:2195-204 pubmed publisher
    ..The present study aims to evaluate the antioxidant effects of curcumin, Nigella sativa oil (NSO) and valproate on the levels of malondialdehyde, nitric oxide, reduced glutathione and the activities ..