coptis

Summary

Summary: A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.

Top Publications

  1. Min Y, Yang M, Lee K, Kim K, Choi S, Lee K. Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino. Arch Pharm Res. 2006;29:757-61 pubmed
    Six protoberberine alkaloids were isolated from the chloroform layer of the rhizome of Coptis japonica Makino (Ranunculaceae)...
  2. Chao D, Lin L, Kao S, Huang H, Chang C, Liang J, et al. Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-?B, and cellular transformation in HepG2 cells. Fitoterapia. 2011;82:696-703 pubmed publisher
    ..ZJW and its components, Coptis chinensis and Evodia rutaecarpa, inhibited AP-1 and NF-?B activities, and suppressed anchorage-independent growth ..
  3. Ikezawa N, Tanaka M, Nagayoshi M, Shinkyo R, Sakaki T, Inouye K, et al. Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. J Biol Chem. 2003;278:38557-65 pubmed
    ..in the biosynthesis of berberine, an antimicrobial benzylisoquinoline alkaloid, were isolated from cultured Coptis japonica cells and characterized. A sequence analysis showed that one C...
  4. Ikezawa N, Iwasa K, Sato F. Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells. J Biol Chem. 2008;283:8810-21 pubmed publisher
    ..characterization of a C-C phenol-coupling P450 cDNA (CYP80G2) from an expressed sequence tag library of cultured Coptis japonica cells...
  5. Zhang Q, Piao X, Piao X, Lu T, Wang D, Kim S. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. Food Chem Toxicol. 2011;49:61-9 pubmed publisher
    b>Coptis chinensis has been used in traditional Chinese medicine to treat inflammatory symptoms. Berberine is the main alkaloid compound of C. chinensis...
  6. Shitan N, Dalmas F, Dan K, Kato N, Ueda K, Sato F, et al. Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport. Phytochemistry. 2013;91:109-16 pubmed publisher
    ..However, knowledge of the membrane transport mechanism of alkaloids is still limited. Coptis japonica, a perennial Ranunculaceous plant, produces the benzylisoquinoline alkaloid berberine...
  7. Wen Q, Zhang N, Cao R, Zhou X, Tang J, Wu N. [Response of isozyme and stress indexes of Coptis chinensis to UV-B radiation]. Zhong Yao Cai. 2012;35:341-6 pubmed
    ..To study the physiological mechanism of anti-stress of Coptic chinensis and provide theoretical basis for its cultivation and promoting its quality...
  8. Wang X, Lin S, Kang H, Dai Z, Bai M, Ma X, et al. The effect of RHIZOMA COPTIDIS and COPTIS CHINENSIS aqueous extract on radiation-induced skin injury in a rat model. BMC Complement Altern Med. 2013;13:105 pubmed publisher
    Radiation-induced skin injury is a common complication of radiotherapy. The RHIZOMA COPTIDIS and COPTIS CHINENSIS aqueous extract (RCE) can ameliorate radiation-induced skin injury in our clinical observation...
  9. Morishige T, Dubouzet E, Choi K, Yazaki K, Sato F. Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells. Eur J Biochem. 2002;269:5659-67 pubmed
    To identify all of the O-methyltransferase genes involved in isoquinoline alkaloid biosynthesis in Coptis japonica cells, we sequenced 1014 cDNA clones isolated from high-alkaloid-producing cultured cells of C. japonica...

More Information

Publications103 found, 100 shown here

  1. Lin C, Ng L, Hsu F, Shieh D, Chiang L. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol. 2004;31:65-9 pubmed
    1. The present study was conducted to evaluate the cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents on hepatoma and leukaemia cells in vitro. 2...
  2. Otani M, Shitan N, Sakai K, Martinoia E, Sato F, Yazaki K. Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica. Plant Physiol. 2005;138:1939-46 pubmed
    ..of an isoquinoline alkaloid, berberine, which is produced and accumulated in the vacuole of cultured cells of Coptis japonica...
  3. Park E, Rhee H, Jung H, Ju S, Lee Y, Lee S, et al. Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytother Res. 2007;21:746-50 pubmed
    ..as potent as current synthetic medicines, the cortex of Phellodendron amurense Rupr (Rutaceae) and the rhizomes of Coptis chinensis Franch (Ranunculaceae) were combined in a 2:1 ratio...
  4. Liu J, He C, Zhou K, Wang J, Kang J. Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. Biochem Biophys Res Commun. 2009;378:174-8 pubmed publisher
    ..The purpose of this study was to determine whether the extracts of coptis, an anti-inflammatory herb, improve the anticancer efficacy of ER antagonists...
  5. Wang L, Ye X, Li X, Chen Z, Chen X, Gao Y, et al. [Metabolism, transformation and distribution of Coptis chinensis total alkaloids in rat]. Zhongguo Zhong Yao Za Zhi. 2010;35:2017-20 pubmed
    To determine the pharmacokinetics, distribution and mutual transformation of the total alkaloids, jatrorrhizine, coptisine, berberine and palmatine from Coptis chinensis in rats.
  6. Zhen Z, Chang B, Li M, Lian F, Chen L, Dong L, et al. Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats. Am J Chin Med. 2011;39:53-63 pubmed
    ..product of the decoction of Dachaihu which has a history of more than 2000 years, has main constituents of Coptis chinensis Franch, Scutellaria baicalensis Georgi, Rheum officinale Baill and Bupleurum chinense DC...
  7. Liu L, Chen Z. Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection. Anal Chim Acta. 2012;737:99-104 pubmed publisher
    ..of four isoquinoline alkaloids including berberine, jatrorrhizine, coptisine and palmatine in Chinese medicine Coptis chinensis. The typical HPLC analysis was performed on WondaSil(®) C18-WR column (250×4...
  8. Tanabe H, Suzuki H, Nagatsu A, Mizukami H, Ogihara Y, Inoue M. Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in. Phytomedicine. 2006;13:334-42 pubmed
    ..Among them, Unsei-in was found to effectively suppress VSMC proliferation, and Coptis rhizome was the responsible constituent crude drug...
  9. Wang X, Xu L, Peng J, Liu K, Zhang L, Zhang Y. In vivo inhibition of S180 tumors by the synergistic effect of the Chinese medicinal herbs Coptis chinensis and Evodia rutaecarpa. Planta Med. 2009;75:1215-20 pubmed publisher
    ..was to investigate the synergistic effect and mechanism of anticancer activity of Zuojinwan ( ZJW) comprising Coptis chinensis Franch ( HL) and Evodia rutaecarpa (Juss.) Benth ( WZY) at a ratio of 6 : 1 (w/w)...
  10. Ye X, Feng Y, Tong Y, Ng K, Tsao S, Lau G, et al. Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. J Ethnopharmacol. 2009;124:130-6 pubmed
    ..To clarify this ethnopharmacological relevance, hepatoprotective effect of Coptidis rhizoma aqueous extract (CRAE) and its possible mechanism were studied in rats intoxicated with carbon tetrachloride (CCl4) in the present study...
  11. Kim J, Jung H, Choi J, Lee N. Identification of anti-inflammatory target genes of Rhizoma coptidis extract in lipopolysaccharide-stimulated RAW264.7 murine macrophage-like cells. J Ethnopharmacol. 2010;130:354-62 pubmed publisher
    ..The aim of this study was to identify the anti-inflammatory target genes of Rhizoma coptidis extract (CEX) in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage-like cells...
  12. Chen H, Ye X, Cui X, He K, Jin Y, Chen Z, et al. Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells. Fitoterapia. 2012;83:67-73 pubmed publisher
    ..berberine, coptisine, palmatine, and jatrorrhizine were considered as the main bio-active compounds in Rhizoma Coptis (RC). Little attention was paid to investigate the pharmacological activity of minor constituents in RC...
  13. Inui T, Kawano N, Shitan N, Yazaki K, Kiuchi F, Kawahara N, et al. Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. Biol Pharm Bull. 2012;35:650-9 pubmed
    b>Coptis japonica (Cj) rhizomes are used as a crude drug for gastroenteritis, since they accumulate antimicrobial berberine. Berberine also shows various useful bioactivities, including cholesterol-lowering activity...
  14. Dubouzet J, Morishige T, Fujii N, An C, Fukusaki E, Ifuku K, et al. Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts. Biosci Biotechnol Biochem. 2005;69:63-70 pubmed
    ..we report the transient RNAi of endogenous biosynthetic genes involved in isoquinoline alkaloid biosynthesis in Coptis japonica protoplasts...
  15. Liu B, Li W, Chang Y, Dong W, Ni L. Extraction of berberine from rhizome of Coptis chinensis Franch using supercritical fluid extraction. J Pharm Biomed Anal. 2006;41:1056-60 pubmed
    Supercritical fluid was used to extract berberine from rhizome of Coptis chinensis Franch. The recovery of berberine was compared with various modifiers, i.e...
  16. Yuan L, Tu D, Ye X, Wu J. Hypoglycemic and hypocholesterolemic effects of Coptis chinensis franch inflorescence. Plant Foods Hum Nutr. 2006;61:139-44 pubmed
    Hypocholesterolemic and hypoglycemic activities of Coptis chinensis franch inflorescence (Coptis inflorescence) were studied using animal models. Serum total and LDL cholesterol of rats fed a diet containing 1% cholesterol and 0...
  17. Minami H, Dubouzet E, Iwasa K, Sato F. Functional analysis of norcoclaurine synthase in Coptis japonica. J Biol Chem. 2007;282:6274-82 pubmed
    ..We report here that a distinct cDNA isolated from Coptis japonica (CjNCS1) also catalyzed NCS reaction as well as a PR10 homologue of C. japonica (CjPR10A)...
  18. Yan D, Jin C, Xiao X, Dong X. Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry. J Biochem Biophys Methods. 2008;70:845-9 pubmed
    ..However, the antimicrobial activity does not vary significantly with methylenedioxy or methoxyl at C9 and C10 on phenyl ring...
  19. Jung H, Min B, Yokozawa T, Lee J, Kim Y, Choi J. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009;32:1433-8 pubmed
    ..As a result, Coptidis Rhizoma and the alkaloids contained therein would clearly have beneficial uses in the development of therapeutic and preventive agents for AD and oxidative stress-related disease...
  20. Gao X, Yang X, Marriott P. Simultaneous analysis of seven alkaloids in Coptis-Evodia herb couple and Zuojin pill by UPLC with accelerated solvent extraction. J Sep Sci. 2010;33:2714-22 pubmed publisher
    ..alkaloids, berberine, palmatine, coptisine, jatrorrhizine, epiberberine, evodiamine, and rutaecarpine, in the Coptis-Evodia herb couple and the Zuojin pill preparation...
  21. Tjong Y, Ip S, Lao L, Fong H, Sung J, Berman B, et al. Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome. J Ethnopharmacol. 2011;135:754-61 pubmed publisher
    b>Coptis chinensis rhizomes (Coptidis Rhizoma, CR), also known as "Huang Lian", is a common component of traditional Chinese herbal formulae used for the relief of abdominal pain and diarrhea...
  22. Yamada Y, Kokabu Y, Chaki K, Yoshimoto T, Ohgaki M, Yoshida S, et al. Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica. Plant Cell Physiol. 2011;52:1131-41 pubmed publisher
    ..We report here the isolation of a novel basic helix-loop-helix protein, CjbHLH1, from IQA-producing Coptis japonica. A BLAST search indicated that CjbHLH1 homologs were only found in plant species that produce IQAs...
  23. Shitan N, Bazin I, Dan K, Obata K, Kigawa K, Ueda K, et al. Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica. Proc Natl Acad Sci U S A. 2003;100:751-6 pubmed
    ..Berberine, a benzylisoquinoline alkaloid, is preferentially accumulated in the rhizome of Coptis japonica, a ranunculaceous plant, whereas gene expression for berberine biosynthetic enzymes has been observed ..
  24. Kato N, Dubouzet E, Kokabu Y, Yoshida S, Taniguchi Y, Dubouzet J, et al. Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica. Plant Cell Physiol. 2007;48:8-18 pubmed
    Selected cultured Coptis japonica cells produce a large amount of the benzylisoquinoline alkaloid berberine. Previous studies have suggested that berberine productivity is controlled at the transcript level of biosynthetic genes...
  25. Inui T, Tamura K, Fujii N, Morishige T, Sato F. Overexpression of Coptis japonica norcoclaurine 6-O-methyltransferase overcomes the rate-limiting step in Benzylisoquinoline alkaloid biosynthesis in cultured Eschscholzia californica. Plant Cell Physiol. 2007;48:252-62 pubmed
    ..We introduced two O-methyltransferase [Coptis japonica norcoclaurine 6-O-methyltransferase (6OMT) and 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase (4'..
  26. Yan H, Sun X, Sun S, Wang S, Zhang J, Wang R, et al. Anti-ultraviolet radiation effects of Coptis chinensis and Phellodendron amurense glycans by immunomodulating and inhibiting oxidative injury. Int J Biol Macromol. 2011;48:720-5 pubmed publisher
    HPLC analysis proved that Coptis chinensis glycan contained Ara, Man, and Gal. The monosaccharide constituents of Phellodendron amurense glycan were determined by HPLC analysis. HPLC analysis proved that P...
  27. Yokozawa T, Ishida A, Cho E, Nakagawa T. The effects of Coptidis Rhizoma extract on a hypercholesterolemic animal model. Phytomedicine. 2003;10:17-22 pubmed
    ..This study demonstrates that Coptidis Rhizoma may be a useful therapy for hypercholesterolemia through reducing oxidative stress and cholesterol levels...
  28. Xu J, Wang L, Xu B. [Research development of Coptis chinensis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26:704-7 pubmed
    To summarize the research and application of ecological planting technique for Coptis chinensis, and describe the recent development of its chemical components, pharmacological effects and clinical applications.
  29. Lu J, Liu Y, Li M, Li B, Xu Y. [Protective effects and its mechanisms of total alkaloids from rhizoma Coptis chinensis on Helicobacter pylori LPS induced gastric lesion in rats]. Zhongguo Zhong Yao Za Zhi. 2007;32:1333-6 pubmed
    To study the effects and its possible mechanisms of total alkaloids (TA) from rhizoma Coptis chinensis on H. pylori LPS induced gastric lesion in rats.
  30. Chen J, Wang F, Liu J, Lee F, Wang X, Yang H. Analysis of alkaloids in Coptis chinensis Franch by accelerated solvent extraction combined with ultra performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections. Anal Chim Acta. 2008;613:184-95 pubmed publisher
    ..UPLC) analysis has been developed for the identification and quantification of major alkaloids in extracts of Coptis chinensis Franch...
  31. Minami H, Kim J, Ikezawa N, Takemura T, Katayama T, Kumagai H, et al. Microbial production of plant benzylisoquinoline alkaloids. Proc Natl Acad Sci U S A. 2008;105:7393-8 pubmed publisher
  32. Feng Y, Siu K, Wang N, Ng K, Tsao S, Nagamatsu T, et al. Bear bile: dilemma of traditional medicinal use and animal protection. J Ethnobiol Ethnomed. 2009;5:2 pubmed publisher
    ..We then discussed the strategy for stopping the trading of bear bile and issues of bear bile related to potential alternative candidates, existing problems in alternative research and work to be done in the future...
  33. Auyeung K, Ko J. Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation. Int J Mol Med. 2009;24:571-7 pubmed
    ..In the present study, we investigated the anti-carcinogenic effects of Coptis chinensis and its major constituent, berberine, in HepG2 hepatocellular carcinoma (HCC) cells and attempted to ..
  34. Zhong G, Huang X, Ma K, Chen S, Qin S. [Quality assessment of Coptis chinensis in China]. Zhongguo Zhong Yao Za Zhi. 2005;30:495-7 pubmed
    To study the dynamic change of the ingredients of Coptis chinensis and evaluate the quality of the crude drugs from main producing areas...
  35. Liu Q, Zhou B, Wang X, Ke Y, Jin Y, Yin L, et al. Establishment of a search library about benzylisoquinoline alkaloids based on selective separation on the binaphthyl column and standard analysis on C18 column. J Sep Sci. 2012;35:3317-25 pubmed publisher
    ..In addition, the distribution of benzylisoquinoline alkaloids in the herbal medicines could be also summarized by searching the source samples in the library. ..
  36. Wang N, Feng Y, Cheung F, Chow O, Wang X, Su W, et al. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats. BMC Complement Altern Med. 2012;12:239 pubmed publisher
  37. Wang R, Lin N. [Research of coptis effect on incidence of neonatal jaundice based on Cox model]. Zhongguo Zhong Yao Za Zhi. 2010;35:1335-8 pubmed
    To learn the effects of coptis in treating neonatal jaundice and to find the index that guides the clinical administration of the medicine...
  38. Takanashi K, Yamada Y, Sasaki T, Yamamoto Y, Sato F, Yazaki K. A multidrug and toxic compound extrusion transporter mediates berberine accumulation into vacuoles in Coptis japonica. Phytochemistry. 2017;138:76-82 pubmed publisher
    ..that a multidrug and toxic compound extrusion protein 1 (CjMATE1) may act as a berberine transporter in cultured Coptis japonica cells. CjMATE1 was found to localize at tonoplasts in C...
  39. Liu Y, Song Y, Qin C, Zhang J. [Studies on quality control standard of zhishidaozhi tabloid pills]. Zhongguo Zhong Yao Za Zhi. 2002;27:838-40 pubmed
    ..To develop the quality control standard of Zhishidaozhi Tabloid Pills...
  40. Harada K, Fukusaki E, Bamba T, Sato F, Kobayashi A. In vivo 15N-enrichment of metabolites in suspension cultured cells and its application to metabolomics. Biotechnol Prog. 2006;22:1003-11 pubmed
    ..Here we present an experiment feeding (15)N-labeled inorganic salts to Arabidopsis (cell line T87) and Coptis cultured cells...
  41. Yin F, Qu X, Zeng W, Shu S. [Study on the autointoxication of aquatic extracts from different parts of Coptis chinensis]. Zhong Yao Cai. 2009;32:329-30 pubmed
    To study the autointoxication of aquatic extracts from different parts of Coptis chinensis...
  42. Park H, Kim Y, Leem K, Park S, Seo J, Kim H, et al. Coptis japonica root extract induces apoptosis through caspase3 activation in SNU-668 human gastric cancer cells. Phytother Res. 2005;19:189-92 pubmed
    ..We investigated the effects of the roots of Coptis japonica var. dissecta (Ranunculaceae) on human gastric cancer cells, SNU-668...
  43. Li J, Zuo F, Zhang L, Nakamura N, Hattori M. [Study on the metabolism of the precipitation of Xiexin decoction in rats I]. Zhongguo Zhong Yao Za Zhi. 2005;30:1673-6 pubmed
    ..The metabolites may be the potential biological components in vivo of baicalin in the precipitation. ..
  44. Wu M, Wang J. [Advance on study in anti-atherosclerosis mechanism of berberine]. Zhongguo Zhong Yao Za Zhi. 2008;33:2013-6 pubmed
    b>Coptis chinensis is a traditional Chinese herb that has the effect of clearing heat and drying dampness, purging fire to eliminate toxin. Berberine is the main alkaloid of C...
  45. Hong M, Tan H, Li S, Cheung F, Wang N, Nagamatsu T, et al. Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds. Int J Mol Sci. 2016;17: pubmed publisher
    ..Furthermore, one of the active compounds in coptis, berbamine may inhibit tumor progression by modulating microRNAs to regulate CSCs...
  46. Habtemariam S. Berberine and inflammatory bowel disease: A concise review. Pharmacol Res. 2016;113:592-599 pubmed publisher
    Berberine is the principal component of many popular medicinal plants (e.g. the genus Berberis, Coptis and Hydrastis among others) with a history of thousands of years of usage in traditional medicine...
  47. Lee C, Lee J, Seok J, Hur G, Park Y, Seol I, et al. Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. Planta Med. 2003;69:523-6 pubmed
    Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively...
  48. Suzuki H, Tanabe H, Mizukami H, Inoue M. Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine. Biol Pharm Bull. 2010;33:677-82 pubmed
    ..In particular, only coptisine induced Mdr1a/1b in A10 cells and stimulated rhodamine 123 efflux. Taken together, coptisine appears to exert VSMC-selective effects on Mdr1a/1b induction in contrast to berberine and palmatine. ..
  49. Jiang L, Zhao F. [Studies of preparing procedures of Yuhuangliang]. Zhong Yao Cai. 2010;33:517-20 pubmed
    ..The optimal preparing method was Rhizoma Coptidis adding amount of 10 mL (0.2 g/mL) juice of wuzhuyu mixed thoroughly, baking at 100 degrees C, for 15 min. The preparing procedure is effective, stable and reliable. ..
  50. Hong H, Chen P, Shih T, Ou C, Jhuo M, Huang Y, et al. Computational pharmaceutical analysis of anti-Alzheimer's Chinese medicine Coptidis Rhizoma alkaloids. Mol Med Rep. 2012;5:142-7 pubmed publisher
  51. Qin Wei Z, Yong Guang L. Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med. 2016;11:978-984 pubmed
    Berberine (BBR), an isoquinoline alkaloid originally isolated from the Chinese herb Coptis chinensis (Huanglian), exhibits anti-inflammatory and immunosuppressive properties...
  52. Jia F, Zou G, Fan J, Yuan Z. Identification of palmatine as an inhibitor of West Nile virus. Arch Virol. 2010;155:1325-9 pubmed publisher
    ..inhibition of West Nile virus (WNV) NS2B-NS3 protease and viral propagation by palmatine, a chemical compound from Coptis chinensis Franch...
  53. Liao Q, Fan D, Xiao X, Luo J, Liu S, Yan D, et al. [Fingerprints of different samples of processed Rhizoma Coptidi by HPLC]. Zhongguo Zhong Yao Za Zhi. 2007;32:210-4 pubmed
    ..The change of property of different processed RC is related with processing adjuvant, the possible mechanism is that new components are produced or the contents of known components have changed due to the adjuvant during processing. ..
  54. Tan B, Ma Y, Shi R, Wang T. Simultaneous quantification of three alkaloids of Coptidis Rhizoma in rat urine by high-performance liquid chromatography: application to pharmacokinetic study. Biopharm Drug Dispos. 2007;28:511-6 pubmed
    ..1% and <or=11.1%, respectively. This method is suitable to determine the three alkaloids of Coptidis Rhizoma in urine simultaneously and thus to investigate the pharmacokinetics of the alkaloids from Xiexin Decoction in rats. ..
  55. Weng X, Li Y, Yang Q, Wang Y, Liu X, Han X, et al. [Effects of Wuji pill compound with different compatibility on cytochrome P450 CYP3A1/3A2 in rat liver microsomes in vitro]. Zhongguo Zhong Yao Za Zhi. 2010;35:1164-9 pubmed
    ..Key words] Wuji pill; CYP3A1/3A2; testosterone; HPLC; different compatibility prescription of traditional Chinese medi-cine ..
  56. Xiang G, Fu T, Fan Q. [Chromosome characteristics of three Coptis species]. Zhongguo Zhong Yao Za Zhi. 2010;35:1367-71 pubmed
    In the present paper, three Coptis species, collected from Sichuan and Chongqing, China, were used for karyotypic analyses. The results indicated that both C. chinensis and C. omeinensis were diploid with chromosome 2n = 2x = 18, and C...
  57. Schramm A, Baburin I, Hering S, Hamburger M. HERG channel inhibitors in extracts of Coptidis rhizoma. Planta Med. 2011;77:692-7 pubmed publisher
    ..The methanolic extract of the TCM herbal drug Coptidis rhizoma (Coptis chinensis Franch., Ranunculaceae) reduced the peak tail hERG current by 31.7 ± 2.0% at 100 µg/mL...
  58. Zhang P, Song S, Liu W, Li L, Zhao W, Zhang Y. [Eeffects of Coptis Chinensis on vasoconstrictive activity of isolated thoracic aorta of normoxic and chronic intermittent hypobaric hypoxic rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011;27:420-5 pubmed
    To observe the effects of Coptis Chinensis on vasoconstrictive activity of isolated thoracic aorta rings of normoxic and chronic intermittent hypobaric hypoxic (CIHH) rats, and to investigate the underlying mechanisms...
  59. Tan P, Liu X, Li J, He J. [Study on the inhibit mechanism primarily of extracts from Coptis on clinical resistant the medicine of Staphylococcus aureus]. Zhong Yao Cai. 2011;34:1575-9 pubmed
    To discuss the inhibit mechanism primarily of extracts from Coptis on clinical resistant the medicine of Staphylococcus aureus...
  60. Sato F. Characterization of plant functions using cultured plant cells, and biotechnological applications. Biosci Biotechnol Biochem. 2013;77:1-9 pubmed
    ..I emphasize the high potential of functionally differentiated cell cultures, as well as some of the pitfalls, in the characterization of plant functions and biotechnological applications. ..
  61. Jiang S, Du P, An L, Yuan G, Sun Z. Anti-diabetic effect of Coptis Chinensis polysaccharide in high-fat diet with STZ-induced diabetic mice. Int J Biol Macromol. 2013;55:118-22 pubmed publisher
    ..In this study, a water-soluble polysaccharide, named as CCPW-1, was extracted and fractioned from the roots of Coptis Chinensis by DEAE Sepharose Fast Flow anion-exchange and Sephadex G-100 column chromatography...
  62. Choi Y, Kim M, Cho I, Kim J, Hong J, Lee T, et al. Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia. J Ethnopharmacol. 2013;149:506-12 pubmed publisher
    ..The results presented here clearly demonstrate that RC could significantly protect mice against LPS-induced acute liver injury. ..
  63. Lee S, Song D, Jang C. Effects of Coptis japonica on morphine-induced conditioned place preference in mice. Arch Pharm Res. 2003;26:540-4 pubmed
    ..In the present study, we investigated the effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice...
  64. Zhang Y, Yang J, Zou X, Liu L, Sun W. [Influence of match-pair of huanglian-rougui on rat intestinal absorption of total huanglian alkali]. Zhongguo Zhong Yao Za Zhi. 2007;32:1521-4 pubmed
    ..Chemical reaction in vitro and intestinal absorption were the key factors of match-pair of huanglian-rougui. ..
  65. Deng Y, Liao Q, Bi K, Yao M, Jiang X, Xie Z. [Analysis of the main components of coptis-evodia herb couple by HPLC-DAD-MS]. Yao Xue Xue Bao. 2008;43:299-302 pubmed
    A comprehensive HPLC-DAD-MS method was developed to study the chemical components of semi-bionic extract of Coptis-Evodia herb couple. The extract was isolated on a Hypersil BDS C18 column (4...
  66. Zhang J, Cai C, Cai Z, Liu G, Luo Y, Yang Z. [Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient]. Ying Yong Sheng Tai Xue Bao. 2008;19:1455-61 pubmed
    An investigation was made on the biomass and major active compounds of wild and cultivated Coptis teeta along an altitude gradient in Nujiang of Yunnan. The results showed that the rhizome and root biomass of wild C...
  67. Lu W, Chen W, Li R. [Study on self-microemulsifying drug delivery system of LianXiang prescription]. Zhong Yao Cai. 2010;33:450-5 pubmed
    ..The total alkaloid of Coptis chinensis--the essential oil of Eugenia caryophyllata-Cremophor RH60-1,2-propylene glycol(40: 20: 60: 20, w/w) was ..
  68. Liu K, Luo T, Zhang Z, Wang T, Kou J, Liu B, et al. Modified Si-Miao-San extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKK?/IRS-1/Akt-dependent pathway. J Ethnopharmacol. 2011;136:473-9 pubmed publisher
    ..The results suggest that mSMS inhibited inflammatory response and improved insulin sensitivity in hepatocytes via an IKK?/IRS-1/Akt-dependent pathway. ..
  69. Morishige T, Choi K, Sato F. In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase. Biosci Biotechnol Biochem. 2004;68:939-41 pubmed
    Coclaurine N-methyltransferase from Coptis japonica catalyzes the N-methylation of coclaurine as well as simple tetrahydroisoquinoline...
  70. Guo Z, Lin Z, Sun R, Sun S, Wang L. [Analysis of contents of berberine in Coptis chinensis of Lichuan]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26:618-21 pubmed
    To determine the contents of berberine in Coptis chinensis of Lichuan and establish its best cultivation scheme...
  71. Xie C, Hu J, Xiao H, Su X, Dong J, Tian R, et al. Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals. Electrophoresis. 2005;26:790-7 pubmed
    ..A comparison of the differences between CEC and capillary zone electrophoresis (CZE) separation was also discussed. ..
  72. Li B, Shang J, Zhou Q. [Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers]. Chin J Integr Med. 2005;11:217-21 pubmed
    To study the effects of total alkaloids (TA) extracted from Rhizoma Coptis Chinensis on experimental gastric ulcer models...
  73. Zhu L, Huang B, Ban X, He J, Chen Y, Han L, et al. Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC-MS analysis of its chemical composition. Food Chem Toxicol. 2012;50:2584-8 pubmed publisher
    Cultivated Coptis chinensis inflorescence has been highly valued in Chinese tea production for many years. The main alkaloid compounds in C...
  74. Li Y, Xu X. [The content condition of effective composition in Sanhuang Xiexin decoction]. Zhongguo Zhong Yao Za Zhi. 2006;31:383-5 pubmed
    ..To investigate the content and existing conditions of baicalin, berberine and rhein in Sanhuang Xiexin decoction suspension...
  75. Chen D, Li L, Peng R, Qu X. [Genetic diversity of Coptis chinensis germplasm based on ISSR analysis]. Zhongguo Zhong Yao Za Zhi. 2006;31:1937-40 pubmed
    To detemine the genetic diversity of Coptis chinensis.
  76. Zhao X, Li Q, Bian L, Zheng X, Zheng J, Zhang Y, et al. Using immobilized G-protein coupled receptors to screen bioactive traditional Chinese medicine compounds with multiple targets. J Pharm Biomed Anal. 2012;70:549-52 pubmed publisher
    ..The aqueous extracts from Salvia miltiorrhiza and Coptis chinensis were also analyzed by the automatic system. The compounds in S...
  77. Terasaka K, Shitan N, Sato F, Maniwa F, Ueda K, Yazaki K. Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins. Plant Cell Physiol. 2003;44:198-200 pubmed
    ..ATP-binding cassette (ABC) proteins, was applied to berberine-producing plant cell cultures, Thalictrum minus and Coptis japonica. One membrane protein at ca. 180 kDa was photoaffinity-labeled with 8-azido-[alpha-(32)P]ATP in the T...
  78. Chen J, Chen X. [Pharmacognostic identification of medicinal Asteropyrum plants in China]. Zhongguo Zhong Yao Za Zhi. 2002;27:94-7 pubmed
    ..To offer evidences for quality control of medicinal Asteropyrum plants...
  79. Tang L, Wei W, Chen L, Liu S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol. 2006;108:109-15 pubmed
  80. Takanashi K, Shitan N, Sugiyama A, Kamimoto Y, Hamamoto M, Iwaki T, et al. Galactinol synthase gene of Coptis japonica is involved in berberine tolerance. Biosci Biotechnol Biochem. 2008;72:398-405 pubmed
    ..In order to clarify the detoxification mechanism of alkaloids, we used cultured cells of Coptis japonica, which are capable of producing a yellow benzylisoquinoline alkaloid, berberine, and accumulate it in the ..
  81. Wang Y, Qiao L, Liu C, Lin N. [Effect and its mechanism of Coptis chinensis on oxidative hemolysis of erythrocytes in mice induced by acetylphenylhydrazine]. Zhongguo Zhong Yao Za Zhi. 2010;35:2449-52 pubmed
    To investigate the effect of Coptis chinensis on oxidative hemolysis of erythrocytes in mice.
  82. Hasada K, Yoshida T, Yamazaki T, Sugimoto N, Nishimura T, Nagatsu A, et al. Application of 1H-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma. J Nat Med. 2011;65:262-7 pubmed publisher
    ..The present quantitative (1)H-NMR method was also applicable to direct determination of protoberberine alkaloid contents in Coptidis Rhizoma...
  83. Kim S, Kim E, Kim W, Lee M, Kim S, Kim T. Coptis japonica Makino extract suppresses angiogenesis through regulation of cell cycle-related proteins. Biosci Biotechnol Biochem. 2016;80:1095-106 pubmed publisher
    ..In this study, we characterized the anti-angiogenic effects of Coptis japonica Makino extract (CJME) and its mechanism of action...
  84. Lim S, Choi H, Kim D. The Mixture of Anemarrhena asphodeloides and Coptis chinensis Attenuates High-Fat Diet-Induced Colitis in Mice. Am J Chin Med. 2017;45:1033-1046 pubmed publisher
    ..b>Coptis chinensis (CC, family Ranunculaceae), which inhibits macrophage activation by inhibiting the binding of ..
  85. Chen Y, Wang X, Sun H, Xing D, Hu J, Wai Z, et al. Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons. Biomed Chromatogr. 2008;22:28-33 pubmed
    ..Moreover, the organic cation transporter inhibitor cimetidine could decrease berberine concentration within the neurons, suggesting that the organic cation transporter might be involved in the berberine transport process...
  86. Wang X, Zhou Q, Han X, Xu L, Peng J. [Anti-cancer activity of Zuojinwan in vivo and influence to tumor markers in mice transplanted with sarcoma 180]. Zhongguo Zhong Yao Za Zhi. 2008;33:2230-4 pubmed
    ..of five kinds of tumor markers (TM) including acid phosphotase (ACP), alkaline phosphotase (AKP), creatine kinase (CK), aldolase (ALD) and lactate dehydrogenase (LDH) in serum compared with Coptis chinensis and Evodia rutaecarpa.
  87. Shen N, Li C, Huan Y, Shen Z. [Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders]. Yao Xue Xue Bao. 2010;45:699-704 pubmed
    ..The mechanisms involve many aspects of the diabetes, including regulating the blood cholesterol and triglyceride, lowering blood glucose, ameliorating the insulin resistant state and influencing the function of the pancreatic beta cell...
  88. Linn Y, Lu J, Lim L, Sun H, Sun J, Zhou Y, et al. Berberine-induced haemolysis revisited: safety of Rhizoma coptidis and Cortex phellodendri in chronic haematological diseases. Phytother Res. 2012;26:682-6 pubmed publisher
    ..There were, however, very few clinical reports of adverse reaction attributable to RC or CP in oral TCM concoction. We conclude that based on traditional dosage and indication, the use of RC and CP in oral concoction is safe...
  89. Chen L, Wang L, Zhang Q, Zhang S, Ye W. [Non-alkaloid chemical constituents from Coptis chinensis]. Zhongguo Zhong Yao Za Zhi. 2012;37:1241-4 pubmed
    To separate and identify chemical constituents from Coptis chinensis. The compounds were separated and purified by various chromatographic techniques...
  90. Tan Z, Zhu R, Shi R, Zhong J, Ma Y, Wang C, et al. Involvement of rat organic cation transporter 2 in the renal uptake of jatrorrhizine. J Pharm Sci. 2013;102:1333-42 pubmed publisher
    Jatrorrhizine is a protoberberine alkaloid derived from Coptis chinensis concentrated extremely in rat kidney...
  91. Li Q, Wu Y, Yuan L, Huang J. [Allelopathic effects of extracts from fibrous roots of Coptis chinensis on two leguminous species]. Zhongguo Zhong Yao Za Zhi. 2013;38:806-11 pubmed
    An experiment was carried out to study the allelopathic effects of Coptis chinensis fibrous root extracts (CRE) on the germination and seedling growth of Vicia faba and Pisum sativum in order to alleviate the allelopathic effects and ..
  92. Ma W, Zhu M, Zhang D, Yang L, Yang T, Li X, et al. Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2. Phytomedicine. 2017;25:45-51 pubmed publisher
    Berberine, a plant-derived compound isolated from Coptis chinensis used in traditional Chinese medicine, has been shown to possess anti-cancer properties...