aquilegia

Summary

Summary: A plant genus of the family RANUNCULACEAE that contains aquiledine, isoaquiledine and cycloartane-type glycosides.

Top Publications

  1. Hodges S, Derieg N. Adaptive radiations: from field to genomic studies. Proc Natl Acad Sci U S A. 2009;106 Suppl 1:9947-54 pubmed publisher
    ..We focus on Aquilegia as a primary example of these advantages and highlight progress in understanding the genetic basis of flower ..
  2. Bylka W, Szaufer Hajdrych M, Matławska I, Goślińska O. Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L. Lett Appl Microbiol. 2004;39:93-7 pubmed
    The aim of this study was to analyse the antimicrobial properties extracts of Aquilegia vulgaris, and their principial flavonoid component and to compare the obtained results with the activity of gentamicin and nystatin.
  3. Puzey J, Kramer E. Identification of conserved Aquilegia coerulea microRNAs and their targets. Gene. 2009;448:46-56 pubmed publisher
    b>Aquilegia is an emerging model organism that is phylogenetically intermediate between the core eudicot and monocot models, Arabidopsis and Oryza...
  4. Whittall J, Hodges S. Pollinator shifts drive increasingly long nectar spurs in columbine flowers. Nature. 2007;447:706-9 pubmed
    ..Here, using a species-level phylogeny of the columbine genus, Aquilegia, we show a significant evolutionary trend for increasing spur length during directional shifts to pollinators ..
  5. Sharma B, Kramer E. Sub- and neo-functionalization of APETALA3 paralogs have contributed to the evolution of novel floral organ identity in Aquilegia (columbine, Ranunculaceae). New Phytol. 2013;197:949-57 pubmed publisher
    Previous studies of the lower eudicot model Aquilegia have revealed differential expression patterns of two APETALA3 (AP3) paralogs that appear to coincide with the development of a distinct fifth floral organ type, the staminodium...
  6. Yu Y, Yi Z, Liang Y. Validate antibacterial mode and find main bioactive components of traditional Chinese medicine Aquilegia oxysepala. Bioorg Med Chem Lett. 2007;17:1855-9 pubmed
    ..investigate antibacterial modes of action and find main antimicrobial component in traditional Chinese medicine, Aquilegia oxysepala, is developed...
  7. Fang G, Blackmon B, Henry D, Staton M, Saski C, Hodges S, et al. Genomic tools development for Aquilegia: construction of a BAC-based physical map. BMC Genomics. 2010;11:621 pubmed publisher
    The genus Aquilegia, consisting of approximately 70 taxa, is a member of the basal eudicot lineage, Ranuculales, which is evolutionarily intermediate between monocots and core eudicots, and represents a relatively unstudied clade in the ..
  8. Herlihy C, Eckert C. Experimental dissection of inbreeding and its adaptive significance in a flowering plant, Aquilegia canadensis (Ranunculaceae). Evolution. 2004;58:2693-703 pubmed
    ..We performed a floral emasculation experiment in 10 populations of Aquilegia canadensis (Ranunculaceae) and used allozyme markers to estimate the relative contribution of each mode of ..
  9. Puzey J, Gerbode S, Hodges S, Kramer E, Mahadevan L. Evolution of spur-length diversity in Aquilegia petals is achieved solely through cell-shape anisotropy. Proc Biol Sci. 2012;279:1640-5 pubmed publisher
    The role of petal spurs and specialized pollinator interactions has been studied since Darwin. Aquilegia petal spurs exhibit striking size and shape diversity, correlated with specialized pollinators ranging from bees to hawkmoths in a ..

More Information

Publications71

  1. El Nekeety A, El Kady A, Soliman M, Hassan N, Abdel Wahhab M. Protective effect of Aquilegia vulgaris (L.) against lead acetate-induced oxidative stress in rats. Food Chem Toxicol. 2009;47:2209-15 pubmed publisher
    ..The current study was carried out to evaluate the antioxidant activity of the ethanol extract of Aquilegia vulgaris (L.) against lead acetate (LA)-induced oxidative stress in male rats...
  2. Whittall J, Voelckel C, Kliebenstein D, Hodges S. Convergence, constraint and the role of gene expression during adaptive radiation: floral anthocyanins in Aquilegia. Mol Ecol. 2006;15:4645-57 pubmed
    ..We use the independent losses of floral anthocyanins in columbines (Aquilegia) to determine the degree of molecular convergence in gene expression across the anthocyanin biosynthetic pathway ..
  3. Kramer E. Aquilegia: a new model for plant development, ecology, and evolution. Annu Rev Plant Biol. 2009;60:261-77 pubmed publisher
    The lower eudicot genus Aquilegia holds enormous potential for investigating aspects of development, ecology, and evolution that are otherwise unrepresented among existing model systems...
  4. Voelckel C, Borevitz J, Kramer E, Hodges S. Within and between whorls: comparative transcriptional profiling of Aquilegia and Arabidopsis. PLoS ONE. 2010;5:e9735 pubmed publisher
    The genus Aquilegia is an emerging model system in plant evolutionary biology predominantly because of its wide variation in floral traits and associated floral ecology. The anatomy of the Aquilegia flower is also very distinct...
  5. Hassan A, Mohamed S, El Nekeety A, Hassan N, Abdel Wahhab M. Aquilegia vulgaris L. extract counteracts oxidative stress and cytotoxicity of fumonisin in rats. Toxicon. 2010;56:8-18 pubmed publisher
    ..The aim of the current study was to evaluate the protective effects of the ethanol extract of Aquilegia vulgaris L...
  6. Kramer E, Hodges S. Aquilegia as a model system for the evolution and ecology of petals. Philos Trans R Soc Lond B Biol Sci. 2010;365:477-90 pubmed publisher
    The ranunculid genus Aquilegia holds extraordinary promise as a model system for investigating a wide range of questions relating to the evolution and ecology of petals...
  7. Hodges S, Kramer E. Columbines. Curr Biol. 2007;17:R992-4 pubmed
  8. Cooper E, Whittall J, Hodges S, Nordborg M. Genetic variation at nuclear loci fails to distinguish two morphologically distinct species of Aquilegia. PLoS ONE. 2010;5:e8655 pubmed publisher
    b>Aquilegia formosa and pubescens are two closely related species belonging to the columbine genus...
  9. Jodynis Liebert J, Matławska I, Bylka W, Murias M. Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. J Ethnopharmacol. 2005;97:351-8 pubmed
    ..w., p.o.) obtained from Aquilegia vulgaris (L.) (Ranunculaceae) herb...
  10. Sharma B, Guo C, Kong H, Kramer E. Petal-specific subfunctionalization of an APETALA3 paralog in the Ranunculales and its implications for petal evolution. New Phytol. 2011;191:870-83 pubmed publisher
    ..Functional analysis of the Aquilegia locus AqAP3-3 has demonstrated that the paralog is required for petal identity with little contribution to the ..
  11. Pabón Mora N, Sharma B, Holappa L, Kramer E, Litt A. The Aquilegia FRUITFULL-like genes play key roles in leaf morphogenesis and inflorescence development. Plant J. 2013;74:197-212 pubmed publisher
    ..diversification of this gene lineage, we studied the role of pre-duplication FUL-like genes in columbine (Aquilegia coerulea)...
  12. Whittall J, Medina Marino A, Zimmer E, Hodges S. Generating single-copy nuclear gene data for a recent adaptive radiation. Mol Phylogenet Evol. 2006;39:124-34 pubmed
    ..primers for a large number of loci in an especially rapid adaptive radiation, that of the flowering plant genus Aquilegia (Ranunculaceae), we developed an efficient method for amplifying multiple single-copy nuclear loci by sequencing ..
  13. Huang S, Tang L, Yu Q, Guo Y. Temporal floral sex allocation in protogynous Aquilegia yabeana contrasts with protandrous species: support for the mating environment hypothesis. Evolution. 2004;58:1131-4 pubmed
    ..This pattern was observed in protogynous Aquilegia yabeana (Ranunculaceae), in which ovule number per flower remained constant whereas pollen number decreased in ..
  14. Li L, Pang D, Liao Q, Xiao H. Genomic and EST microsatellite markers for Aquilegia flabellata and cross-amplification in A. oxysepala (Ranunculaceae). Am J Bot. 2011;98:e213-5 pubmed publisher
    The goal of this study was to identify genomic and expressed sequence tag (EST)-derived microsatellite markers from the species Aquilegia flabellata and assess their transferability in A. oxysepala.
  15. Fior S, Li M, Oxelman B, Viola R, Hodges S, Ometto L, et al. Spatiotemporal reconstruction of the Aquilegia rapid radiation through next-generation sequencing of rapidly evolving cpDNA regions. New Phytol. 2013;198:579-92 pubmed publisher
    b>Aquilegia is a well-known model system in the field of evolutionary biology, but obtaining a resolved and well-supported phylogenetic reconstruction for the genus has been hindered by its recent and rapid diversification...
  16. Garrido J, Fenu G, Mattana E, Bacchetta G. Spatial genetic structure of Aquilegia taxa endemic to the island of Sardinia. Ann Bot. 2012;109:953-64 pubmed publisher
    ..is made of the spatial genetic structure of all known locations of the three Sardinian endemic species of Aquilegia in order to determine the relative roles of gene flow and genetic drift as underlying evolutionary forces ..
  17. Kramer E, Holappa L, Gould B, Jaramillo M, Setnikov D, Santiago P. Elaboration of B gene function to include the identity of novel floral organs in the lower eudicot Aquilegia. Plant Cell. 2007;19:750-66 pubmed
    The basal eudicot Aquilegia (columbine) has an unusual floral structure that includes two morphologically distinct whorls of petaloid organs and a clearly differentiated fifth organ type, the staminodium...
  18. Bartkowska M, Wong A, Sagar S, Zeng L, Eckert C. Lack of spatial structure for phenotypic and genetic variation despite high self-fertilization in Aquilegia canadensis (Ranunculaceae). Heredity (Edinb). 2018;121:605-615 pubmed publisher
    ..Although the short-lived plant Aquilegia canadensis produces large, complex, nectar-rich flowers, 75% of seed, on average, are self-fertilized...
  19. Du H, Ran F, Dong H, Wen J, Li J, Liang Z. Genome-Wide Analysis, Classification, Evolution, and Expression Analysis of the Cytochrome P450 93 Family in Land Plants. PLoS ONE. 2016;11:e0165020 pubmed publisher
    ..CYP93G and CYP93J are monocot-specific; CYP93E is unique to legumes; CYP93H and CYP93K are only found in Aquilegia coerulea, and CYP93D is Brassicaceae-specific...
  20. Monniaux M, Hay A. Cells, walls, and endless forms. Curr Opin Plant Biol. 2016;34:114-121 pubmed publisher
    ..modified cell growth patterns, including oriented cell expansion or division, found in the long petal spurs of Aquilegia flowers, and the Sarracenia purpurea pitcher leaf, respectively...
  21. Hao D, Ge G, Xiao P, Wang P, Yang L. Drug metabolism and pharmacokinetic diversity of ranunculaceae medicinal compounds. Curr Drug Metab. 2015;16:294-321 pubmed
    ..toxicity (ADME/T) of Ranunculaceae compounds, there is a lack of DMPK studies of traditional medicinal genera Aquilegia, Thalictrum and Clematis...
  22. Lega M, Fior S, Li M, Leonardi S, Varotto C. Genetic Drift Linked to Heterogeneous Landscape and Ecological Specialization Drives Diversification in the Alpine Endemic Columbine Aquilegia thalictrifolia. J Hered. 2014;105:542-554 pubmed
    ..The model genus Aquilegia represents a textbook example of a rapid and recent radiation through the Northern hemisphere, with the majority ..
  23. Clark S, Verwoerd W. A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. BMC Bioinformatics. 2011;12:343 pubmed publisher
    ..correspond to observational results of the same genes being co-regulated for eliminating floral pigmentation in Aquilegia and; ii) the impact of another MCS requiring CHS suppression, corresponds to findings where the suppression of ..
  24. Sharma B, Kramer E. Aquilegia B gene homologs promote petaloidy of the sepals and maintenance of the C domain boundary. Evodevo. 2017;8:22 pubmed publisher
    The model Aquilegia coerulea x "Origami" possesses several interesting floral features, including petaloid sepals that are morphologically distinct from the true petals and a broad domain containing many whorls of stamens...
  25. Abdel Aziem S, El Nekeety A, Barakat I, Mohamed M, Abdel Wahhab M. Aquilegia vulgaris extract protects against the oxidative stress and the mutagenic effects of cadmium in Balb/c mice. Exp Toxicol Pathol. 2011;63:337-44 pubmed publisher
    ..The aim of the current work was to evaluate the protective effect of Aquilegia vulgaris extract against the oxidative stress and the genotoxicity induced by Cd using the chromosomal ..
  26. Yu Q, Huang S. Flexible stigma presentation assists context-dependent pollination in a wild columbine. New Phytol. 2006;169:237-41 pubmed
    ..Here we investigated stigma presentation in the spring-flowering herb Aquilegia yabeana, whose linear stigma gradually develops over the lifetime of the flower...
  27. Gleason E, Kramer E. Characterization of Aquilegia Polycomb Repressive Complex 2 homologs reveals absence of imprinting. Gene. 2012;507:54-60 pubmed publisher
    ..Here we examine the evolution and expression of the PRC2 and VEL PHD families in Aquilegia, a member of the lower eudicot order Ranunculales and an emerging model for the investigation of plant ecology, ..
  28. Alcántara J, Bastida J, Rey P. Linking divergent selection on vegetative traits to environmental variation and phenotypic diversification in the Iberian columbines (Aquilegia). J Evol Biol. 2010;23:1218-33 pubmed publisher
    ..b>Aquilegia)...
  29. Yoshimitsu H, Nishida M, Nohara T. Two labdane diterpene and megastigmane glycosides from Aquilegia hybrida. Chem Pharm Bull (Tokyo). 2008;56:1009-12 pubmed
    ..and B, and a new megastigmane glycoside, named aquoside C, have been isolated from the air-dried aerial parts of Aquilegia hybrida together with three known compounds comprising a phenolic glycoside and two flavone C-glycosides...
  30. Gleason E, Kramer E. Conserved roles for Polycomb Repressive Complex 2 in the regulation of lateral organ development in Aquilegia x coerulea 'Origami'. BMC Plant Biol. 2013;13:185 pubmed publisher
    ..While the functions of these transcription factors are known to be deeply conserved, whether or not their regulation by PRC2 is similarly conserved remains an open question...
  31. Griffin C, Eckert C. Experimental analysis of biparental inbreeding in a self-fertilizing plant. Evolution. 2003;57:1513-9 pubmed
    ..We estimated biparental inbreeding in two populations of the largely self-fertilizing plant Aquilegia canadensis using standard inference as well as a novel experiment comparing apparent selfing between plants that ..
  32. Chen S, Gao G, Wang L, Liao M, Yang J, Xiao P. [Studies on the chemical constituents from Aquilegia ecalcarata Maxim]. Zhongguo Zhong Yao Za Zhi. 2001;26:472-4 pubmed
    To study the chemical constituents from Aquilegia ecalcarata.
  33. Chen S, Wang L, Gao G, Liao M, Xiao P. [Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey]. Zhongguo Zhong Yao Za Zhi. 1999;24:158-60, 191 pubmed
    To study the chemical constituents in Aquilegia oxysepala.
  34. Ree R. Detecting the historical signature of key innovations using stochastic models of character evolution and cladogenesis. Evolution. 2005;59:257-65 pubmed
    ..Applied to a well-known example in plants, nectar spurs in columbines, the method gives much stronger support to the key innovation hypothesis than previous tests...
  35. Adamska T, Młynarczyk W, Jodynis Liebert J, Bylka W, Matławska I. Hepatoprotective effect of the extract and isocytisoside from Aquilegia vulgaris. Phytother Res. 2003;17:691-6 pubmed
    ..4'-methoxy-5,7-dihydroxy fl avone 6-C-beta-glucopyranoside (isocytisoside, ISOC) from the leaves and stems of Aquilegia vulgaris L. were studied using the CCl(4)-induced hepatotoxicity test...
  36. Nishida M, Yoshimitsu H, Okawa M, Nohara T. Four new cycloartane glycosides from Aquilegia vulgaris and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction. Chem Pharm Bull (Tokyo). 2003;51:683-7 pubmed
    Four new cycloartane glycosides, named aquilegiosides C-F, were isolated from the dried aerial parts of Aquilegia vulgaris. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence...
  37. Canto A, Perez R, Medrano M, Castellanos M, Herrera C. Intra-plant variation in nectar sugar composition in two Aquilegia species (Ranunculaceae): contrasting patterns under field and glasshouse conditions. Ann Bot. 2007;99:653-60 pubmed
    ..variation in nectar sugar composition in field and glasshouse plants of the bumblebee-pollinated perennial herbs Aquilegia vulgaris subsp. vulgaris and Aquilegia pyrenaica subsp. cazorlensis (Ranunculaceae)...
  38. Michaelson L, Longman A, Sayanova O, Stobart A, Napier J. Isolation and characterization of a cDNA encoding a Delta8 sphingolipid desaturase from Aquilegia vulgaris. Biochem Soc Trans. 2002;30:1073-5 pubmed
    We have isolated a cDNA encoding the Delta(8) sphingolipid desaturase from the plant Aquilegia vulgaris L. via a PCR-based strategy using primers designed to target the conserved histidine box regions of microsomal desaturases...
  39. Hale C, Frelich L, Reich P, Pastor J. Exotic earthworm effects on hardwood forest floor, nutrient availability and native plants: a mesocosm study. Oecologia. 2008;155:509-18 pubmed
    ..N and P availability, and the mortality and biomass of four native understory plant species (Acer saccharum, Aquilegia canadensis, Aralia racemosa, and Carex pensylvanica)...
  40. Brunet J, Holmquist K. The influence of distinct pollinators on female and male reproductive success in the Rocky Mountain columbine. Mol Ecol. 2009;18:3745-58 pubmed publisher
    ..two kinds of pollinators on reproductive success via male and female functions in the Rocky Mountain columbine, Aquilegia coerulea...
  41. Brunet J, Sweet H. Impact of insect pollinator group and floral display size on outcrossing rate. Evolution. 2006;60:234-46 pubmed
    ..examined the influence of distinct insect pollinator groups on outcrossing rate in the rocky mountain columbine, Aquilegia coerulea...
  42. Lavergne S, Debussche M, Thompson J. Limitations on reproductive success in endemic Aquilegia viscosa (Ranunculaceae) relative to its widespread congener Aquilegia vulgaris: the interplay of herbivory and pollination. Oecologia. 2005;142:212-20 pubmed
    ..study is to compare the relative impact of herbivory and pollination on maternal reproductive success in endemic Aquilegia viscosa and its widespread congener Aquilegia vulgaris...
  43. Bylka W. E- and Z-p-methoxycinnamic acid from Aquilegia vulgaris. Acta Pol Pharm. 2004;61:307-8 pubmed
    ..Two isomers E- and Z-p-methoxycinnamic acid were isolated from the leaves with stems of A. vulgaris L. and their structures were determined by 1HMR and 13C NMR spectral data...
  44. Mushtaq S, Aga M, Qazi P, Ali M, Shah A, Lone S, et al. Isolation, characterization and HPLC quantification of compounds from Aquilegia fragrans Benth: Their in vitro antibacterial activities against bovine mastitis pathogens. J Ethnopharmacol. 2016;178:9-12 pubmed publisher
    The underground parts of Aquilegia fragrans are traditionally used for the treatment of wounds and various inflammatory diseases like bovine mastitis...
  45. Blein T, Pulido A, Vialette Guiraud A, Nikovics K, Morin H, Hay A, et al. A conserved molecular framework for compound leaf development. Science. 2008;322:1835-9 pubmed publisher
    ..This domain has a dual role promoting leaflet separation locally and leaflet formation at distance. In this manner, boundaries of compound leaves resemble boundaries functioning during animal development...
  46. Sharma B, Kramer E. Virus-induced gene silencing in the rapid cycling columbine Aquilegia coerulea "Origami". Methods Mol Biol. 2013;975:71-81 pubmed publisher
    b>Aquilegia Origami is an emerging model system for ecology and evolution, which has numerous genetic and genomic tools. Virus-induced gene silencing (VIGS) has been established as an effective approach to study gene function in Aquilegia...
  47. Kujawska M, Jodynis Liebert J, Ewertowska M, Adamska T, Matlawska I, Bylka W. Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats. Indian J Exp Biol. 2007;45:702-11 pubmed
    ..It can be concluded that the protective effect of the A. vulgaris extract in CCl4-induced liver injury is mediated by inhibition of microsomal lipid peroxidation and restoring activity of some antioxidant and related enzymes...
  48. Jankovics T, Bai Y, Kovács G, Bardin M, Nicot P, Toyoda H, et al. Oidium neolycopersici: intraspecific variability inferred from amplified fragment length polymorphism analysis and relationship with closely related powdery mildew fungi infecting various plant species. Phytopathology. 2008;98:529-40 pubmed publisher
    ..The relationship between O. neolycopersici and powdery mildew anamorphs infecting Aquilegia vulgaris, Chelidonium majus, Passiflora caerulea, and Sedum alboroseum was also investigated...
  49. Jodynis Liebert J, Adamska T, Ewertowska M, Bylka W, Matławska I. Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats. Exp Toxicol Pathol. 2009;61:443-51 pubmed publisher
    ..w.day) given 2 days a week for 6 weeks; group III was treated simultaneously with ethanol extract of Aquilegia vulgaris (100 mg/kg b.w.day) for 6 weeks; group V with silymarin, positive control, at a dose of 100 mg/kg b.w...
  50. Eckert C, Ozimec B, Herlihy C, Griffin C, Routley M. Floral morphology mediates temporal variation in the mating system of a self-compatible plant. Ecology. 2009;90:1540-8 pubmed
    ..in the proportion of seeds self-fertilized (s) between two years within 19 populations of the short-lived herb Aquilegia canadensis. Selfing varied widely among populations (range in s = 0.17-1.00, mean s = 0...
  51. Ritland K. Evolutionary potential in the wild: more than meets the eye. Mol Ecol. 2011;20:3494-5 pubmed publisher
    The genus Aquilegia consists of 60-70 perennial plant species widely distributed throughout the northern hemisphere. Its flowers have a delicate and ornamental appearance that makes them a favourite of gardeners...
  52. Castellanos M, Alcántara J, Rey P, Bastida J. Intra-population comparison of vegetative and floral trait heritabilities estimated from molecular markers in wild Aquilegia populations. Mol Ecol. 2011;20:3513-24 pubmed publisher
    ..For several taxa of the perennial herb genus Aquilegia, we estimated heritabilities of floral and vegetative traits and, combined with estimates of natural selection, ..
  53. Sasaki Y, Nagumo S. [Study of plant DNA polymorphism--experiments for students]. Yakugaku Zasshi. 2005;125:205-11 pubmed
    ..Total DNA is extracted from a piece of leaf derived from Aconitum carmichaeli or Aquilegia flabellate, the nuclear 5...
  54. Zhu R, Gao Y, Xu L, Zhang Q. Genetic diversity of Aquilegia (Ranunculaceae) species and cultivars assessed by AFLPs. Genet Mol Res. 2011;10:817-27 pubmed publisher
    Species of the genus Aquilegia are exceptionally diverse in their floral morphology and color, commonly known as columbine. They are widely planted ornamentals and are highly attractive for hummingbirds...
  55. Herrera C, García I, Perez R. Invisible floral larcenies: microbial communities degrade floral nectar of bumble bee-pollinated plants. Ecology. 2008;89:2369-76 pubmed
    ..individual nectary level in flowers of three southern Spanish bumble bee-pollinated plants (Helleborus foetidus, Aquilegia vulgaris, and Aquilegia pyrenaica cazorlensis)...
  56. Ewertowska M, Jodynis Liebert J, Kujawska M, Adamska T, Matławska I, Szaufer Hajdrych M. Effect of Aquilegia vulgaris (L.) ethyl ether extract on liver antioxidant defense system in rats. Int J Occup Med Environ Health. 2009;22:115-23 pubmed publisher
    The ethyl ether extract from Aquilegia vulgaris (L.) (Ranunculaceae) contains a lot of phenolic acids...
  57. Murias M, Jodynis Liebert J, Matławska I, Bylka W. Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris. Fitoterapia. 2005;76:476-80 pubmed
    Two extracts (ethyl acetate and ethanol) and isocytisoside obtained from Aquilegia vulgaris were tested for their antioxidant and free radical scavenging activity in vitro...
  58. Ennos R. Floral evolution: spurred on by pollinators. Heredity (Edinb). 2008;100:3-4 pubmed
  59. Brunet J. Pollinators of the Rocky Mountain columbine: temporal variation, functional groups and associations with floral traits. Ann Bot. 2009;103:1567-78 pubmed publisher
    ..The variation in three floral traits is described and correlations between pollinator type, functional pollinator groups or altitude and floral traits are examined...
  60. Nishida M, Yoshimitsu H, Okawa M, Nohara T. Four new cycloartane glycosides from Aquilegia vulgaris. Chem Pharm Bull (Tokyo). 2003;51:956-9 pubmed
    Four new cycloartane glycosides, named aquilegiosides G-J, were isolated from the dried aerial parts of Aquilegia vulgaris. Their structures were determined by spectroscopic analysis and chemical evidence.
  61. Jaime R, Rey P, Alcántara J, Bastida J. Glandular trichomes as an inflorescence defence mechanism against insect herbivores in Iberian columbines. Oecologia. 2013;172:1051-60 pubmed publisher
    ..role of glandular trichomes against herbivorous insects in the inflorescence of Iberian columbines (genus Aquilegia), and its inter-population and inter-taxa variation in relation to herbivore abundance and potential selective ..
  62. Qi Y, Yang Y. [Medicinal plant resources of Trib. Isopyreae and prospects of exploitation]. Zhong Yao Cai. 2002;25:87-9 pubmed
    ..This paper reports their resources, habitats and medicinal properties. On the basis of referring to the native and abroad medical studies on the plants from same Trilbe, their prospects of exploitation were advised...