punicaceae

Summary

Summary: A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida that is a small family with a single genus.

Top Publications

  1. Jurenka J. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008;13:128-44 pubmed
    ..Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity...
  2. Seeram N, Adams L, Henning S, Niu Y, Zhang Y, Nair M, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005;16:360-7 pubmed
    ..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...
  3. Duman A, Ozgen M, Dayisoylu K, Erbil N, Durgac C. Antimicrobial activity of six pomegranate (Punica granatum L.) varieties and their relation to some of their pomological and phytonutrient characteristics. Molecules. 2009;14:1808-17 pubmed publisher
    ..The MIC values for active pomegranate extracts ranged between 30 and >90 microg/mL. The results obtained appeared to confirm the antimicrobial potential of the Punica granatum varieties...
  4. Seeram N, Zhang Y, McKeever R, Henning S, Lee R, Suchard M, et al. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food. 2008;11:390-4 pubmed publisher
    ..This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl...
  5. Katz S, Newman R, Lansky E. Punica granatum: heuristic treatment for diabetes mellitus. J Med Food. 2007;10:213-7 pubmed
    ..Pomegranate fractions and their active compounds hold potential and are worthy of further investigations as safe and effective medical treatments for diabetes mellitus and its pathological consequences...
  6. Rosenblat M, Volkova N, Aviram M. Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2. Atherosclerosis. 2010;212:86-92 pubmed publisher
    ..To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression...
  7. Dkhil M. Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract. Parasitol Res. 2013;112:2639-46 pubmed publisher
    ..The study revealed that pomegranate as a natural product has protective effects against E. papillata-induced coccidiosis as well as it possesses an anthelmintic activity...
  8. Bagri P, Ali M, Aeri V, Bhowmik M, Sultana S. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 2009;47:50-4 pubmed publisher
  9. Adhami V, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer. 2009;61:811-5 pubmed publisher
    ..This review focuses on recent investigations into the effects of pomegranate fruit on cancer...

More Information

Publications76

  1. Abdel Moneim A. Evaluating the potential role of pomegranate peel in aluminum-induced oxidative stress and histopathological alterations in brain of female rats. Biol Trace Elem Res. 2012;150:328-36 pubmed publisher
  2. Endo E, Cortez D, Ueda Nakamura T, Nakamura C, Dias Filho B. Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans. Res Microbiol. 2010;161:534-40 pubmed publisher
  3. Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol. 2012;143:397-405 pubmed publisher
    Punica granatum L. (Punicaceae) has been used for centuries in many cultures for the prevention and treatment of a wide number of health disorders such as inflammation, diabetes, diarrhea, dysentery, dental plaque and to combat intestinal ..
  4. Dell Agli M, Galli G, Corbett Y, Taramelli D, Lucantoni L, Habluetzel A, et al. Antiplasmodial activity of Punica granatum L. fruit rind. J Ethnopharmacol. 2009;125:279-85 pubmed publisher
    Sun-dried rind of the immature fruit of Punica granatum L. (Punicaceae) (Pg) is presently used as a herbal formulation (OMARIA) in Orissa, India, for the therapy and prophylaxis of malaria...
  5. Lee S, Wu Y, Chien L, Chen S, Tzeng Y, Wu T. Proteomic exploration of the impacts of pomegranate fruit juice on the global gene expression of prostate cancer cell. Proteomics. 2012;12:3251-62 pubmed publisher
  6. McCarrell E, Gould S, Fielder M, Kelly A, El Sankary W, Naughton D. Antimicrobial activities of pomegranate rind extracts: enhancement by addition of metal salts and vitamin C. BMC Complement Altern Med. 2008;8:64 pubmed publisher
    ..The aim of this study was to determine the antimicrobial activities of combinations of pomegranate rind extracts (PRE) with a range of metals salts with the added stabiliser vitamin C...
  7. Fawole O, Makunga N, Opara U. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract. BMC Complement Altern Med. 2012;12:200 pubmed publisher
    ..This study evaluated, using in vitro assays, the antibacterial, antioxidant, and tyrosinase-inhibition activities of methanolic extracts from peels of seven commercially grown pomegranate cultivars...
  8. Hajimahmoodi M, Oveisi M, Sadeghi N, Jannat B, Hadjibabaie M, Farahani E, et al. Antioxidant properties of peel and pulp hydro extract in ten Persian pomegranate cultivars. Pak J Biol Sci. 2008;11:1600-4 pubmed
    ..The peel extract of sweet white peel cultivar appeared to have more potential as a health supplement rich in natural antioxidants compared to the pulp and peel extracts of other pomegranate cultivars...
  9. Shukla M, Gupta K, Rasheed Z, Khan K, Haqqi T. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition. 2008;24:733-43 pubmed publisher
    ..The present study was designed to evaluate a standardized preparation of POMx using collagen-induced arthritis (CIA) in mice, a widely used animal model of rheumatoid arthritis...
  10. Ouachrif A, Khalki H, Chaib S, Mountassir M, Aboufatima R, Farouk L, et al. Comparative study of the anti-inflammatory and antinociceptive effects of two varieties of Punica granatum. Pharm Biol. 2012;50:429-38 pubmed publisher
    ..Studies have shown that pomegranate, Punica granatum Linn. (Lythraceae), has remarkable biological and medicinal properties...
  11. Al Zoreky N. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. Int J Food Microbiol. 2009;134:244-8 pubmed publisher
    ..Phytochemical analyses revealed the presence of active inhibitors in peels, including phenolics and flavonoids. The activity of WME was related to its higher content (262.5 mg/g) of total phenolics...
  12. Hong M, Seeram N, Heber D. Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem. 2008;19:848-55 pubmed publisher
  13. Sánchez Lamar A, Fonseca G, Fuentes J, Cozzi R, Cundari E, Fiore M, et al. Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol. 2008;115:416-22 pubmed
    Punica granatum L. (Punicaceae) whole fruit extracts, have been used in Cuban traditional medicine as an effective drug for the treatment of respiratory diseases. This species showed interesting anti-viral activity, e.g...
  14. Rettig M, Heber D, An J, Seeram N, Rao J, Liu H, et al. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol Cancer Ther. 2008;7:2662-71 pubmed publisher
    ..Our study represents the first description of PE as a promising dietary agent for the prevention of the emergence of androgen independence that is driven in part by heightened NF-kappaB activity...
  15. Sartippour M, Seeram N, Rao J, Moro A, Harris D, Henning S, et al. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol. 2008;32:475-80 pubmed
    ..Further studies in humans are needed to confirm that angiogenesis can be inhibited by an ellagitannin-rich pomegranate extract administered orally as a dietary supplement...
  16. Basu A, Penugonda K. Pomegranate juice: a heart-healthy fruit juice. Nutr Rev. 2009;67:49-56 pubmed publisher
    ..Thus, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation, and evidence to date suggests it may be prudent to include this fruit juice in a heart-healthy diet...
  17. Xu K, Zhu C, Kim M, Yamahara J, Li Y. Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. J Ethnopharmacol. 2009;123:280-7 pubmed publisher
    ..Fatty liver is the most common cause of abnormal liver function tests. We investigated the effect and its underlying mechanism of pomegranate flower (PGF), a traditional antidiabetic medicine, on fatty liver...
  18. Hadipour Jahromy M, Mozaffari Kermani R. Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice. Phytother Res. 2010;24:182-5 pubmed publisher
    ..No cell proliferation or inflammatory cells were detected in the synovial fluid. The effectiveness of pomegranate juice in improving histopathological damage is emphasized and its chondroprotective effect in vivo highlighted...
  19. Rasheed Z, Akhtar N, Haqqi T. Pomegranate extract inhibits the interleukin-1?-induced activation of MKK-3, p38?-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. Arthritis Res Ther. 2010;12:R195 pubmed publisher
    ..In this study we determined the effect of a standardized pomegranate extract (PE) on the IL-1?-induced activation of MKK3/6, p38-MAPK isoforms and the activation of transcription factor RUNX-2 in primary human OA chondrocytes...
  20. Johanningsmeier S, Harris G. Pomegranate as a functional food and nutraceutical source. Annu Rev Food Sci Technol. 2011;2:181-201 pubmed publisher
    ..A more complete characterization of pomegranate components and their physiological fate may provide mechanistic insight into the potential health benefits observed in clinical trials...
  21. Shen C, Smith B, Lo D, Chyu M, Dunn D, Chen C, et al. Dietary polyphenols and mechanisms of osteoarthritis. J Nutr Biochem. 2012;23:1367-77 pubmed publisher
  22. Hartman R, Shah A, Fagan A, Schwetye K, Parsadanian M, Schulman R, et al. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol Dis. 2006;24:506-15 pubmed
    ..These results suggest that further studies to validate and determine the mechanism of these effects, as well as whether substances in PJ may be useful in AD, should be considered...
  23. Seeram N, Henning S, Zhang Y, Suchard M, Li Z, Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr. 2006;136:2481-5 pubmed
    ..Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established...
  24. Khan N, Hadi N, Afaq F, Syed D, Kweon M, Mukhtar H. Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis. 2007;28:163-73 pubmed
    ..2%, wt/vol) to athymic nude mice implanted with A549 cells resulted in a significant inhibition in tumor growth. Our results provide a suggestion that PFE can be a useful chemopreventive/chemotherapeutic agent against human lung cancer...
  25. Braga L, Leite A, Xavier K, Takahashi J, Bemquerer M, Chartone Souza E, et al. Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus. Can J Microbiol. 2005;51:541-7 pubmed
    ..aureus resistant to PGME was low and they did not survive. In conclusion, PGME dramatically enhanced the activity of all antibiotics tested, and thus, offers an alternative for the extension of the useful lifetime of these antibiotics...
  26. Machado T, Pinto A, Pinto M, Leal I, Silva M, Amaral A, et al. In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents. 2003;21:279-84 pubmed
    ..The results indicate that these natural products can be effective potential candidates for the development of new strategies to treat MRSA infections...
  27. Lansky E, Newman R. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007;109:177-206 pubmed
  28. Braga L, Shupp J, Cummings C, Jett M, Takahashi J, Carmo L, et al. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. J Ethnopharmacol. 2005;96:335-9 pubmed
    In Brazil, pomegranate (Punica granatum L. (Punicaceae)) is widely used as a phytotherapeutic agent. This study evaluates the effect of pomegranate extract on Staphylococcus aureus FRI 722 growth and subsequent enterotoxin production...
  29. Vidal A, Fallarero A, Peña B, Medina M, Gra B, Rivera F, et al. Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol. 2003;89:295-300 pubmed
    ..b>Punicaceae), used in Cuban traditional medicine a.o. for the treatment of respiratory diseases...
  30. Ahmed S, Wang N, Hafeez B, Cheruvu V, Haqqi T. Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro. J Nutr. 2005;135:2096-102 pubmed
    ..Taken together, these novel results indicate that PFE or compounds derived from it may inhibit cartilage degradation in OA and may also be a useful nutritive supplement for maintaining joint integrity and function...
  31. Afaq F, Malik A, Syed D, Maes D, Matsui M, Mukhtar H. Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol. 2005;81:38-45 pubmed
  32. Mehta R, Lansky E. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur J Cancer Prev. 2004;13:345-8 pubmed
    ..The results highlight enhanced breast cancer preventive potential both for the purified compound peak B and for pomegranate seed oil, both greater than that previously reported for pomegranate fermented juice polyphenols...
  33. Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis. 2006;187:363-71 pubmed
  34. Huang T, Peng G, Kota B, Li G, Yamahara J, Roufogalis B, et al. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component. Toxicol Appl Pharmacol. 2005;207:160-9 pubmed
    ..Thus, our findings indicate that PPAR-gamma is a molecular target for PGF extract and its prominent component gallic acid, and provide a better understanding of the potential mechanism of the anti-diabetic action of PGF...
  35. Malik A, Afaq F, Sarfaraz S, Adhami V, Syed D, Mukhtar H. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005;102:14813-8 pubmed
    ..We suggest that pomegranate juice may have cancer-chemopreventive as well as cancer-chemotherapeutic effects against prostate cancer in humans...
  36. Mori Okamoto J, Otawara Hamamoto Y, Yamato H, Yoshimura H. Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol. 2004;92:93-101 pubmed
    ..These changes suggest that the pomegranate extract inhibits ovariectomy-stimulated bone turnover. It is thus conceivable that pomegranate is clinically effective on a depressive state and bone loss in menopausal syndrome in women...
  37. Seeram N, Lee R, Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta. 2004;348:63-8 pubmed
    ..We conducted in vivo studies whereby a human subject consumed pomegranate juice (PJ) (180 ml) containing EA (25 mg) and ETs (318 mg, as punicalagins, the major fruit ellagitannin)...
  38. Aslam M, Lansky E, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006;103:311-8 pubmed
  39. Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T. Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation. Biosci Biotechnol Biochem. 2005;69:2368-73 pubmed
    ..PE, when taken orally, may be used as an effective whitening agent for the skin...
  40. Malik A, Mukhtar H. Prostate cancer prevention through pomegranate fruit. Cell Cycle. 2006;5:371-3 pubmed
  41. Sudheesh S, Vijayalakshmi N. Flavonoids from Punica granatum--potential antiperoxidative agents. Fitoterapia. 2005;76:181-6 pubmed
    ..Concentrations of glutathione in the tissues were also increased...
  42. Adams L, Seeram N, Aggarwal B, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem. 2006;54:980-5 pubmed
    ..Therefore, the polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells...
  43. Afaq F, Saleem M, Krueger C, Reed J, Mukhtar H. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer. 2005;113:423-33 pubmed
    ..Thus, an in-depth study to define active agent(s) in PFE capable of affording antitumor-promoting effect is warranted...
  44. Cerdá B, Espín J, Parra S, Martinez P, Tomas Barberan F. The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. Eur J Nutr. 2004;43:205-20 pubmed
    ..The most potent in vitro antioxidant polyphenol from this juice is the ellagitannin punicalagin. However, the bioavailability of ellagitannins, including punicalagin, has not been previously described in humans...
  45. Cerdá B, Llorach R, Ceron J, Espín J, Tomas Barberan F. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr. 2003;42:18-28 pubmed
    ..Nothing is known about the bioavailability and metabolism of punicalagin or other food ellagitannins. The present work aims to evaluate the bioavailability and metabolism of punicalagin in the rat as an animal model...
  46. Mertens Talcott S, Jilma Stohlawetz P, Rios J, Hingorani L, Derendorf H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food Chem. 2006;54:8956-61 pubmed
    ..Overall, this study demonstrated the absorbability of EA from a pomegranate extract high in ellagitannin content and its ex vivo antioxidant effects...
  47. Ranjbar M, Zibaee A, Sendi J. A trypsin-like proteinase in the midgut of Ectomyelois ceratoniae Zeller (Lepidoptera: Pyralidae): purification, characterization, and host plant inhibitors. Arch Insect Biochem Physiol. 2014;85:1-12 pubmed publisher
    ..Characterization of serine proteinases of insects mainly trypsins is one of the promising methods to decrease population and damages via extracting their inhibitors and providing resistant varieties. ..
  48. Pirbalouti A, Azizi S, Koohpayeh A, Hamedi B. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. Acta Pol Pharm. 2010;67:511-6 pubmed
    The flowers of Malva sylvestris Linn. (Malvaceae) and Punica granatum Linn. (Punicaceae) are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, bum, wound and for their ..
  49. Seeram N, Aronson W, Zhang Y, Henning S, Moro A, Lee R, et al. Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem. 2007;55:7732-7 pubmed
    ..This warrants future human tissue bioavailability studies and further clinical studies in men with CaP. ..
  50. Shalimu D, Sun J, Baskin C, Baskin J, Sun L, Liu Y. Changes in oxidative patterns during dormancy break by warm and cold stratification in seeds of an edible fruit tree. AoB Plants. 2016;8: pubmed publisher
  51. Yılmaz B, Usta C. Ellagic acid-induced endothelium-dependent and endothelium-independent vasorelaxation in rat thoracic aortic rings and the underlying mechanism. Phytother Res. 2013;27:285-9 pubmed publisher
    ..The results of the present study have demonstrated in the rat thoracic aorta that EA causes vasorelaxations, which are partly modulated via endothelium-dependent mechanisms and through inhibition of calcium influx. ..
  52. Mestry S, Gawali N, Pai S, Gursahani M, Dhodi J, Munshi R, et al. Punica granatum improves renal function in gentamicin-induced nephropathy in rats via attenuation of oxidative stress. J Ayurveda Integr Med. 2018;: pubmed publisher
    ..Data suggests that MPGL attenuated oxidative stress associated renal injury by preserving antioxidant enzymes, reducing lipid peroxidation and inhibiting inflammatory mediators such as TNF-α. ..
  53. Voruganti S, Yamsani S, Ravula S, Gannu R, Yamsani M. Effect of pomegranate juice on intestinal transport and pharmacokinetics of nitrendipine in rats. Phytother Res. 2012;26:1240-5 pubmed publisher
    ..Therefore, the concomitant use of PJ, as food supplement, and nitrendipine should be avoided, although further clinical studies need to be undertaken in order to confirm this finding. ..
  54. Mansour S, Sangi S, Harsha S, Khaleel M, Ibrahim A. Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract. Asian Pac J Trop Biomed. 2013;3:563-8 pubmed publisher
    ..These results show that administration of PE, NSO and OO could modify sperm characteristics and antioxidant activity of adult male wistar rats. ..
  55. Parmar H, Kar A. Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice. Biofactors. 2007;31:17-24 pubmed
    ..Subsequent phytochemical analysis indicated that the high content of total polyphenols in the test peels might be related to the antidiabetic and antiperoxidative effects of the test peels. ..
  56. Park H, Moon E, Kim A, Kim M, Lee S, Lee J, et al. Extract of Punica granatum inhibits skin photoaging induced by UVB irradiation. Int J Dermatol. 2010;49:276-82 pubmed publisher
    ..The major polyphenols in PG, particularly catechin, play a significant role in its photoprotective effects on UVB-induced skin damage. ..
  57. Calani L, Beghè D, Mena P, Del Rio D, Bruni R, Fabbri A, et al. Ultra-HPLC-MS(n) (Poly)phenolic profiling and chemometric analysis of juices from ancient Punica granatum L. Cultivars: a nontargeted approach. J Agric Food Chem. 2013;61:5600-9 pubmed publisher
  58. Kuang N, He Y, Xu Z, Bao L, He R, Kurihara H. [Effect of pomegranate peel extracts on experimental prostatitis rats]. Zhong Yao Cai. 2009;32:235-9 pubmed
    ..05 or P < 0.01). PPE can markedly improve the protective function of oxidation resistance, it may involve its regulatory action on anti-oxidation. ..
  59. Stockton A, Farhat G, McDougall G, Al Dujaili E. Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial. J Nutr Sci. 2017;6:e39 pubmed publisher
    ..Results suggest that PE may reduce blood pressure and possibly prevent hypertension in the normotensive population. Further large trials are required to elucidate this effect...
  60. Kazemi M, Karim R, Mirhosseini H, Abdul Hamid A. Optimization of pulsed ultrasound-assisted technique for extraction of phenolics from pomegranate peel of Malas variety: Punicalagin and hydroxybenzoic acids. Food Chem. 2016;206:156-66 pubmed publisher
    ..Punicalagin and ellagic acid were the most predominant phenolic compounds quantified in the pomegranate peel extract (PPE) from Malas variety. PPE contained a minor content of gallic acid. ..
  61. Khan G, Gorin M, Rosenthal D, Pan Q, Bao L, Wu Z, et al. Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integr Cancer Ther. 2009;8:242-53 pubmed publisher
    ..Because nuclear transcription factor-kB (NF-kB) is known to regulate cell survival, proliferation, tumorigenesis, and inflammation, it was postulated that PFEs may exert anticancer effects at least in part by modulating NF-kB activity...
  62. Yan H, Peng K, Wang Q, Gu Z, Lu Y, Zhao J, et al. Effect of pomegranate peel polyphenol gel on cutaneous wound healing in alloxan-induced diabetic rats. Chin Med J (Engl). 2013;126:1700-6 pubmed
    Pomegranate (punica granatum) belongs to the family Punicaceae, and its peel has been used as a traditional Chinese medicine because of its efficacy in restraining intestine, promoting hemostasis, and killing parasites...
  63. Abdel Moneim A, Othman M, Mohmoud S, El Deib K. Pomegranate peel attenuates aluminum-induced hepatorenal toxicity. Toxicol Mech Methods. 2013;23:624-33 pubmed publisher
  64. Catola S, Marino G, Emiliani G, Huseynova T, Musayev M, Akparov Z, et al. Physiological and metabolomic analysis of Punica granatum (L.) under drought stress. Planta. 2016;243:441-9 pubmed publisher
    ..These data evidence a possible role of the oxylipin pathway in the response to water stress in pomegranate plants. ..
  65. Diamanti A, Igoumenidis P, Mourtzinos I, Yannakopoulou K, Karathanos V. Green extraction of polyphenols from whole pomegranate fruit using cyclodextrins. Food Chem. 2017;214:61-66 pubmed publisher
    ..Pomegranate liquid extracts may be used as raw materials for several end-users in the food, cosmetic and pharmaceutical industries. ..
  66. Abid M, Cheikhrouhou S, Renard C, Bureau S, Cuvelier G, Attia H, et al. Characterization of pectins extracted from pomegranate peel and their gelling properties. Food Chem. 2017;215:318-25 pubmed publisher
    ..The variation in the pectin gel formation between varieties was attributed to difference in pectin characteristics particularly the hydrodynamic volume and the neutral sugar content. ..
  67. Kasimsetty S, Bialonska D, Reddy M, Thornton C, Willett K, Ferreira D. Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. J Agric Food Chem. 2009;57:10636-44 pubmed publisher
    ..Western blots of the CYP1B1 protein indicated that the urolithins interfered with the expression of CYP1B1 protein. Thus, urolithins were found to display a dual mode mechanism by decreasing CYP1B1 activity and expression...