rheum

Summary

Summary: A plant genus of the family POLYGONACEAE. Members contain chrysophanic acid, rhein, EMODIN, and other ANTHRAQUINONES. The roots were formerly used as PURGATIVES.

Top Publications

  1. Li W, Chan S, Guo D, Chung M, Leung T, Yu P. Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines. J Ethnopharmacol. 2009;124:251-6 pubmed publisher
    b>Rheum officinale Baill. (Da Huang) is one of the herbs commonly used in traditional Chinese medicine formulae against cancer. The traditional decoction is similar to the water extract used in the present study.
  2. Zhao Y, Wang J, Zhou G, Shan L, Xiao X. Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats. Basic Clin Pharmacol Toxicol. 2009;104:463-9 pubmed publisher
    ..effects of anthraquinones from Rhubarb, a Chinese herbal medicine, consisting of the root and rhizome of Rheum palmatum L., R. tanguticum Maxim. Ex Balf., or R. officinale Baill...
  3. Mishra S, Tiwari S, Shrivastava A, Srivastava S, Boudh G, Chourasia S, et al. Antidyslipidemic effect and antioxidant activity of anthraquinone derivatives from Rheum emodi rhizomes in dyslipidemic rats. J Nat Med. 2014;68:363-71 pubmed publisher
    The aim of the present study was to evaluate the antidyslipidemic effect of ethanolic extract of Rheum emodi rhizomes and its constituents in Triton-WR-1339 and high-fat diet (HFD)-induced dyslipidemic rats...
  4. Abe T, Morita H, Noma H, Kohno T, Noguchi H, Abe I. Structure function analysis of benzalacetone synthase from Rheum palmatum. Bioorg Med Chem Lett. 2007;17:3161-6 pubmed
    ..The diketide forming activity of Rheum palmatum BAS is attributed to the characteristic substitution of the conserved active-site Phe215 with Leu (..
  5. Wang J, Zhao Y, Xiao X, Li H, Zhao H, Zhang P, et al. Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats. J Ethnopharmacol. 2009;124:18-25 pubmed publisher
    ..In this investigation an attempt was made to assess the value and toxic potential of rhubarb to treat CRF...
  6. Heger M, Ventskovskiy B, Borzenko I, Kneis K, Rettenberger R, Kaszkin Bettag M, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006;13:744-59 pubmed
    To investigate the efficacy and safety of the special extract ERr 731 from the roots of Rheum rhaponticum compared to placebo in perimenopausal women with climacteric complaints.
  7. Ghawana S, Kumar S, Ahuja P. Early low-temperature responsive mitogen activated protein kinases RaMPK1 and RaMPK2 from Rheum australe D. Don respond differentially to diverse stresses. Mol Biol Rep. 2010;37:933-8 pubmed publisher
    b>Rheum grows luxuriantly in a niche of low temperature (LT) at high altitudes in Himalayan belt. The plant is expected to harbor novel genes particularly for tolerance to LT...
  8. Liu L, Yuan S, Long Y, Guo Z, Sun Y, Li Y, et al. Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid. Int Immunopharmacol. 2009;9:1568-77 pubmed publisher
    ..In our previous study, Rheum tanguticum polysaccharide (RTP), extracted from traditional Chinese medicine rhubarb, targeted mannose receptor, ..
  9. Jin H, Sakaida I, Tsuchiya M, Okita K. Herbal medicine Rhei rhizome prevents liver fibrosis in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Life Sci. 2005;76:2805-16 pubmed
    ..These results indicate that Rhei rhizome significantly reduces liver fibrosis by the direct inhibition of stellate cell activation without reducing hepatocyte cell death...

More Information

Publications63

  1. Kogure K, Yamauchi I, Tokumura A, Kondou K, Tanaka N, Takaishi Y, et al. Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan. Phytomedicine. 2004;11:645-51 pubmed
    ..penninervis, Inula macrophylla, Prangos pabularia, P. tschimganica and Rheum maximowiczii collected in Uzbekistan on ADP/Fe2+-induced lipid peroxidation of egg yolk phosphatidylcholine ..
  2. Mase A, Makino B, Tsuchiya N, Yamamoto M, Kase Y, Takeda S, et al. Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis. J Ethnopharmacol. 2010;127:742-9 pubmed publisher
    ..In the present study, we investigated the active ingredients of ICKT...
  3. Abe I, Takahashi Y, Morita H, Noguchi H. Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum. Eur J Biochem. 2001;268:3354-9 pubmed
    ..A cDNA encoding BAS was for the first time cloned and sequenced from rhubarb (Rheum palmatum), a medicinal plant rich in phenylbutanoids including pharmaceutically important phenylbutanone glucoside,..
  4. Alam M, Javed K, Jafri M. Effect of Rheum emodi (Revand Hindi) on renal functions in rats. J Ethnopharmacol. 2005;96:121-5 pubmed
    ..effects of water-soluble (W-S) and water-insoluble (W-INS) portions of the alcoholic extract of Revand Hindi (Rheum emodi) were investigated on cadmium chloride, mercuric chloride, potassium dichromate and gentamicin-induced ..
  5. Kaszkin Bettag M, Ventskovskiy B, Kravchenko A, Rettenberger R, Richardson A, Heger P, et al. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause. 2007;14:270-83 pubmed
    To investigate the efficacy of the special extract ERr 731 from the roots of Rheum rhaponticum compared with placebo on anxiety, health state, and general well-being in perimenopausal women.
  6. Ye M, Han J, Chen H, Zheng J, Guo D. Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2007;18:82-91 pubmed
    ..From six rhubarb species, official (Rheum officinale, R. palmatum, and R. tanguticum) and unofficial (R. franzenbachii, R. hotaoense, and R...
  7. Huang Q, Lu G, Shen H, Chung M, Ong C. Anti-cancer properties of anthraquinones from rhubarb. Med Res Rev. 2007;27:609-30 pubmed
    ..In this review the toxicological and anti-neoplastic potentials of the main anthraquinones from Rhubarb, Rheum palmatum, will be highlighted...
  8. Cheema S, Goel V, Basu T, Agellon L. Dietary rhubarb (Rheum rhaponticum) stalk fibre does not lower plasma cholesterol levels in diabetic rats. Br J Nutr. 2003;89:201-6 pubmed
    Rhubarb (Rheum rhapontiam) stalk fibre was previously shown to be hypolipidaemic under clinical and experimental conditions...
  9. Wei W, Chen H, Ni Z, Liu H, Tong H, Fan L, et al. Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation. Int J Oncol. 2011;39:1381-90 pubmed publisher
  10. Choi S, Lee S, Jang K, Chung S, Park S, Kang H, et al. Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum. Arch Pharm Res. 2005;28:1027-30 pubmed
    ..fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin (1) and ..
  11. Wang A, Yang M, Liu J. Molecular phylogeny, recent radiation and evolution of gross morphology of the rhubarb genus Rheum (Polygonaceae) inferred from chloroplast DNA trnL-F sequences. Ann Bot. 2005;96:489-98 pubmed
    b>Rheum, a highly diversified genus with about 60 species, is mainly confined to the mountainous and desert regions of the Qinghai-Tibetan plateau and adjacent areas...
  12. Liu L, Mei Q, Liu L, Zhang F, Liu Z, Wang Z, et al. Protective effects of Rheum tanguticum polysaccharide against hydrogen peroxide-induced intestinal epithelial cell injury. World J Gastroenterol. 2005;11:1503-7 pubmed
    To describe the effect of Rheum tanguticum polysaccharide (RTP) on hydrogen peroxide-induced human intestinal epithelial cell injury.
  13. Kim J, Kim H, Pandit S, Chang K, Jeon J. Inhibitory effect of a bioactivity-guided fraction from Rheum undulatum on the acid production of Streptococcus mutans biofilms at sub-MIC levels. Fitoterapia. 2011;82:352-6 pubmed publisher
    b>Rheum undulatum root has been used traditionally in Korea for the treatment of dental diseases. The purpose of this study was to separate a fraction from R...
  14. Morita H, Shimokawa Y, Tanio M, Kato R, Noguchi H, Sugio S, et al. A structure-based mechanism for benzalacetone synthase from Rheum palmatum. Proc Natl Acad Sci U S A. 2010;107:669-73 pubmed publisher
    ..We solved the crystal structures of both the wild-type and chalcone-producing I207L/L208F mutant of Rheum palmatum BAS at 1.8 A resolution...
  15. Zhao L, Liang J, Li W, Cheng K, Xia X, Deng X, et al. The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L. Molecules. 2011;16:5928-37 pubmed publisher
    ..UAE) was applied to the extraction of anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) from Rheum palmatum L...
  16. Qin Y, Wang J, Kong W, Zhao Y, Yang H, Dai C, et al. The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism. J Ethnopharmacol. 2011;133:1096-102 pubmed publisher
    ..The present study investigated the pharmacological effects of different extracts of rhubarb on intestinal function of mice, further to explore possible reasons for the adverse effects of long-term use of rhubarb as a purgative...
  17. Yang C, Shen L, Xie Z, Jiang X, Liang N, Chen Z. [Experimental studies of therapeutic effect of Rheum officinale on acute pancreatitis]. Zhong Yao Cai. 2011;34:84-8 pubmed
    To investigate the therapeutic effect of Rheum off?cinale on acute pancreatitis.
  18. Xiong H, Luo J, Hou W, Xiao H, Yang Z. The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo. J Ethnopharmacol. 2011;133:718-23 pubmed publisher
    ..We initiated this study to test if emodin is the active ingredients from Rheum tanguticum (R...
  19. Li Z, Li L, Sun Y, Li J. Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract. Chemotherapy. 2007;53:320-6 pubmed
    ..In search for new anti-HBV agents with higher efficiency and less side effects, the anti-HBV activities of traditional Chinese medicine Rheum palmatum L. ethanol extract (RPE) and isolated anthraquinones were evaluated.
  20. Tang T, Yin L, Yang J, Shan G. Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur J Pharmacol. 2007;567:177-85 pubmed
    Emodin (1, 3, 8-trihydroxy-6-methyl-anthraquinone) is an anthraquinone derivative from the roots of Rheum officinale Baill, a Chinese herb widely and traditionally used for wound healing...
  21. Kuo P, Hsu Y, Ng L, Lin C. Rhein inhibits the growth and induces the apoptosis of Hep G2 cells. Planta Med. 2004;70:12-6 pubmed
    ..Taken together, p53 and the CD95/CD95L apoptotic system possibly participated in the antiproliferative activity of rhein in Hep G2 cells...
  22. Tang J, Zhang J, Wu Y, Li Z. Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity. Phytother Res. 2006;20:1046-51 pubmed
    Angelica sinensis (Oliv.) Diels (DG), Ligusticum chuanxiong Hort. (CX) and Rheum palmatum L. (DH), three well known traditional Chinese medicines (TCM), have been used widely for the treatment of various types of disorders in China...
  23. Wober J, Möller F, Richter T, Unger C, Weigt C, Jandausch A, et al. Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds. J Steroid Biochem Mol Biol. 2007;107:191-201 pubmed
    The special extract ERr 731 from the roots of Rheum rhaponticum is the major constituent of Phytoestrol N which is used for the treatment of climacteric symptoms in menopausal women...
  24. Wang J, Zhao H, Zhao Y, Jin C, Liu D, Kong W, et al. Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury. PLoS ONE. 2011;6:e24498 pubmed publisher
  25. Krenn L, Presser A, Pradhan R, Bahr B, Paper D, Mayer K, et al. Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi. J Nat Prod. 2003;66:1107-9 pubmed
    A sulfated emodin glucoside, emodin 8-O-beta-D-glucopyranosyl-6-O-sulfate (1), was isolated from the roots of Rheum emodi in an investigation of the active constituents of this Nepalese medicinal plant, and its structure was determined ..
  26. Shia C, Juang S, Tsai S, Chang P, Kuo S, Hou Y, et al. Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity. Planta Med. 2009;75:1386-92 pubmed publisher
    Anthraquinones are a major group of polyphenols in the rhizome of Rheum palmatum L. (RP). This study investigated the metabolism and pharmacokinetics of anthraqinones in RP decoction in rats...
  27. Shi P, Huang Z, Chen G. Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. Am J Chin Med. 2008;36:805-13 pubmed
    ..It is expected that rhein will be effective and useful as a new agent in hepatocelluar carcinoma treatment in the future...
  28. Singh N, Gupta A, Sinha A, Ahuja P. High-performance thin layer chromatography method for quantitative determination of four major anthraquinone derivatives in Rheum emodi. J Chromatogr A. 2005;1077:202-6 pubmed
    ..e. physcion, chrysophanol, emodin and chrysophanol glycoside in Rheum emodi is described. HPTLC of anthraquinone derivatives was performed on pre-coated RP-18 F254S HPTLC plates...
  29. Kim D, Park E, Bae E, Han M. Metabolism of rhaponticin and chrysophanol 8-o-beta-D-glucopyranoside from the rhizome of rheum undulatum by human intestinal bacteria and their anti-allergic actions. Biol Pharm Bull. 2000;23:830-3 pubmed
    Rhaponticin and chrysophanol 8-o-beta-D-glucopyranoside isolated from the rhizomes of Rheum undulatum (Family Polygonaceae) are metabolized to rhapontigenin and chrysophanol, respectively, by human intestinal microflora...
  30. Cai Y, Sun M, Xing J, Corke H. Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. J Agric Food Chem. 2004;52:7884-90 pubmed
    The phenolic constituents in the roots of Rheum officinale and Rubia cordifolia were identified with the aid of high-performance liquid chromatography and liquid chromatography-mass spectrometry and by comparison with authentic standards...
  31. Song J, Yang T, Chang K, Han S, Yi H, Jeon J. In vitro anti-cariogenic activity of dichloromethane fraction from Rheum undulatum L. root. Arch Pharm Res. 2006;29:490-6 pubmed
    This study aimed to evaluate in vitro effects of Rheum undulatum L...
  32. Raal A, Pokk P, Arend A, Aunapuu M, Jõgi J, Okva K, et al. Trans-resveratrol alone and hydroxystilbenes of rhubarb (Rheum rhaponticum L.) root reduce liver damage induced by chronic ethanol administration: a comparative study in mice. Phytother Res. 2009;23:525-32 pubmed publisher
    The hepatoprotective effects and pharmacokinetics of trans-resveratrol and hydroxystilbenes of the garden rhubarb (Rheum rhaponticum L., R. rhaponticum) root ethanol extract were studied...
  33. Pussa T, Raudsepp P, Kuzina K, Raal A. Polyphenolic composition of roots and petioles of Rheum rhaponticum L. Phytochem Anal. 2009;20:98-103 pubmed publisher
    Various species of the genus Rheum (Polygonaceae) are known for their high content of medicinally important hydroxyanthraquinones...
  34. Jin W, Wang Y, Ge R, Shi H, Jia C, Tu P. Simultaneous analysis of multiple bioactive constituents in Rheum tanguticum Maxim. ex Balf. by high-performance liquid chromatography coupled to tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21:2351-60 pubmed
    ..ionization mass spectrometry (ESI-MS) to simultaneously analyze multiple bioactive constituents in the extract of Rheum tanguticum Maxim. ex Balf. (Dahuang), a traditional Chinese medicine (TCM)...
  35. Wang X, Yang R, Feng S, Hou X, Zhang Y, Li Y, et al. Genetic variation in Rheum palmatum and Rheum tanguticum (Polygonaceae), two medicinally and endemic species in China using ISSR markers. PLoS ONE. 2012;7:e51667 pubmed publisher
    Both Rheum palmatum and R. tanguticum are important but endangered medicinal plants endemic to China...
  36. Chu X, Wei M, Yang X, Cao Q, Xie X, Guan M, et al. Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma. Food Chem Toxicol. 2012;50:2368-75 pubmed publisher
    ..These findings suggest that emodin may effectively delay the progression of airway inflammation and could be used as a therapy for patients with allergic airway inflammation...
  37. Sun Y, Wang A, Wan D, Wang Q, Liu J. Rapid radiation of Rheum (Polygonaceae) and parallel evolution of morphological traits. Mol Phylogenet Evol. 2012;63:150-8 pubmed publisher
    In this study, we examined diversification history of Rheum and tested the hypothesis that morphological traits related to plant 'body-plans' evolved in parallel in this genus...
  38. Möller F, Zierau O, Jandausch A, Rettenberger R, Kaszkin Bettag M, Vollmer G. Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells. Phytomedicine. 2007;14:716-26 pubmed
    The special extract ERr 731 from the roots of Rheum rhaponticum is the major constituent of Phytoestrol N which is used for the alleviation of menopausal symptoms...
  39. Jin W, Ge R, Wei Q, Bao T, Shi H, Tu P. Development of high-performance liquid chromatographic fingerprint for the quality control of Rheum tanguticum Maxim. ex Balf. J Chromatogr A. 2006;1132:320-4 pubmed
    ..by using high-performance liquid chromatography-photodiode array detection (HPLC-DAD) to control the quality of Rheum tanguticum Maxim. ex Balf...
  40. Wang J, Zhao H, Kong W, Jin C, Zhao Y, Qu Y, et al. Microcalorimetric assay on the antimicrobial property of five hydroxyanthraquinone derivatives in rhubarb (Rheum palmatum L.) to Bifidobacterium adolescentis. Phytomedicine. 2010;17:684-9 pubmed publisher
    ..The influence of substituent groups on anti- B. adolescentis activity might be related with the polarity and the sequence was carboxyl>hydroxyl>hydroxylmethyl>methyl and methoxyl...
  41. Iizuka A, Iijima O, Kondo K, Itakura H, Yoshie F, Miyamoto H, et al. Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness. J Ethnopharmacol. 2004;91:89-94 pubmed
    ..We consider this a useful method for selecting of Rhubarb and propose a new scientific approach for the selection of natural medicines...
  42. Liu L, Wang Z, Xu C, Pan B, Mei Q, Long Y, et al. Effects of Rheum tanguticum polysaccharide on TNBS -induced colitis and CD4+T cells in rats. World J Gastroenterol. 2003;9:2284-8 pubmed
    To study the effects of Rheum tanguticum polysaccharide(-1) (RTP(-1)) on ulcerative colitis in rats induced by 2, 4, 6-trinitrophene sulphonic acid (TNBS) and their possible mechanism.
  43. Lee J, Kim J, Kim C. Pharmacokinetic analysis of rhein in Rheum undulatum L. J Ethnopharmacol. 2003;84:5-9 pubmed
    This research aims to identify the main active compounds of Rhei undulati Rhizoma (roots of Rheum undulatum LINNE) and determine the types of anthraquinones absorbed into the body and their pharmacokinetic parameters...
  44. Ibrahim M, Khan A, Tiwari S, Habeeb M, Khaja M, Habibullah C. Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies. World J Gastroenterol. 2006;12:7136-42 pubmed
    to evaluate the antibacterial activity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi).
  45. Han J, Ye M, Xu M, Qiao X, Chen H, Wang B, et al. Comparison of phenolic compounds of rhubarbs in the section deserticola with Rheum palmatum by HPLC-DAD-ESI-MSn. Planta Med. 2008;74:873-9 pubmed publisher
    A sophisticated LC-ESI-MS (n) method was utilized for the analysis of the phenolic compounds in five unofficial RHEUM species for the first time. These species belong to the section deserticola Maxim...
  46. Yang D, Fushimi H, Cai S, Komatsu K. Molecular analysis of Rheum species used as Rhei Rhizoma based on the chloroplast matK gene sequence and its application for identification. Biol Pharm Bull. 2004;27:375-83 pubmed
    ..In the Japanese Pharmacopoeia, Rhei Rhizoma is prescribed for four Rheum species, Rheum palmatum, R. tanguticum, R. officinale, and R...
  47. Liu L, Guo Z, Lv Z, Sun Y, Cao W, Zhang R, et al. The beneficial effect of Rheum tanguticum polysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: the role of macrophage mannose receptor in inflammation and immune response. Int Immunopharmacol. 2008;8:1481-92 pubmed publisher
    ..In the present study, we evaluated the effect of Rheum tanguticum polysaccharide (RTP), a water soluble fraction extracted from rhubarb, on protection from inflammation ..
  48. Zhao X, Zheng Z, Feng S, Shi Z, Chen D. A TD-DFT study on the photo-physicochemical properties of chrysophanol from rheum. Int J Mol Sci. 2009;10:3186-93 pubmed publisher
    ..Based on the photosensitive activities, chrysophanol may be potentially used as the photodynamic medicine for clinical therapy of the diseases occurring on the shallow surface and vascular capillary diseases...
  49. Wang H, Song H, Yue J, Li J, Hou Y, Deng J. Rheum officinale (a traditional Chinese medicine) for chronic kidney disease. Cochrane Database Syst Rev. 2012;:CD008000 pubmed publisher
    ..Despite such interventions, CKD incidence and mortality rates continue to increase. Rheum officinale (Da Huang) a medicinal herb used widely in China to treat CKD has been reported to offer a range of ..
  50. Kang S, Lee C, Choung E, Bak J, Bae J, Yoo H, et al. Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum. Arch Pharm Res. 2008;31:722-6 pubmed publisher
    The Rheum palmatum L., a traditional medicine in Korea, was screened for their estrogenic activity in a recombinant yeast system with a human estrogen receptor (ER) expression plasmid and a reporter plasmid used in a previous study...
  51. Suresh Babu K, Tiwari A, Srinivas P, Ali A, China Raju B, Rao J. Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson. Bioorg Med Chem Lett. 2004;14:3841-5 pubmed
    The methanolic extract of rhizome of Himalayan rhubarb Rheum emodi displayed mild yeast as well as mammalian intestinal alpha-glucosidase inhibitory activity...
  52. Wang L, Li D, Bao C, You J, Wang Z, Shi Y, et al. Ultrasonic extraction and separation of anthraquinones from Rheum palmatum L. Ultrason Sonochem. 2008;15:738-46 pubmed publisher
    ..extraction (UNE) was developed and applied to extract anthraquinones (emodin, aloe-emodin and rhein) from Rheum palmatum L...
  53. Papke A, Kretzschmar G, Zierau O, Kaszkin Bettag M, Vollmer G. Effects of the special extract ERr 731 from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats. J Steroid Biochem Mol Biol. 2009;117:176-84 pubmed publisher
    A recent clinical study with a two-year application of the extract ERr 731 from Rheum rhaponticum demonstrated its efficacy and potentially suggested it safety regarding unwanted endometrial side effects...
  54. Yang F, Zhang T, Tian G, Cao H, Liu Q, Ito Y. Preparative isolation and purification of hydroxyanthraquinones from Rheum officinale Baill by high-speed counter-current chromatography using pH-modulated stepwise elution. J Chromatogr A. 1999;858:103-7 pubmed
    ..chromatography was successfully used for the isolation and purification of hydroxyanthraquinones from Rheum officinale Baill (Dahuang) using pH-modulated stepwise elution...