coix

Summary

Summary: A plant genus of the family POACEAE. The seed is used in folk medicine (DRUGS, CHINESE HERBAL).

Top Publications

  1. Kim S, Yun S, Jung B, Lee E, Hahm D, Shim I, et al. Hypolipidemic effects of crude extract of adlay seed (Coix lachrymajobi var. mayuen) in obesity rat fed high fat diet: relations of TNF-alpha and leptin mRNA expressions and serum lipid levels. Life Sci. 2004;75:1391-404 pubmed
    ..Accordingly, the oriental medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling...
  2. Lu X, Liu W, Wu J, Li M, Wang J, Wu J, et al. A polysaccharide fraction of adlay seed (Coixlachryma-jobi L.) induces apoptosis in human non-small cell lung cancer A549 cells. Biochem Biophys Res Commun. 2013;430:846-51 pubmed publisher
    Different seed extracts from Coix lachryma-jobi (adlay seed) have been used for the treatment of various cancers in China, and clinical data support the use of these extracts for cancer therapy; however, their underlying molecular ..
  3. Ha D, Nam Trung T, Bich Thu N, Van On T, Hai Nam N, Van Men C, et al. Adlay seed extract (Coix lachryma-jobi L.) decreased adipocyte differentiation and increased glucose uptake in 3T3-L1 cells. J Med Food. 2010;13:1331-9 pubmed publisher
    The aim of the present study was to investigate effects of the ethyl acetate fraction of an ethanol extract of Coix lachryma-jobi (ECLJ) on glucose uptake and adipocyte differentiation in 3T3-L1 cells...
  4. Han Y, Wang G, Liu Z, Liu J, Yue W, Song R, et al. Divergence in centromere structure distinguishes related genomes in Coix lacryma-jobi and its wild relative. Chromosoma. 2010;119:89-98 pubmed publisher
    ..Here, we report the sequences of one centromere-associated bacterial artificial chromosome clone from a Coix lacryma-jobi library. Two Ty3/gypsy-class retrotransposons, centromeric retrotransposon of C...
  5. Yu F, Gao J, Zeng Y, Liu C. Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats. J Sci Food Agric. 2011;91:1843-8 pubmed publisher
    Adlay (Coix lacryma-jobi L. subsp. ma-yuen (Romanet) T. Koyama (family Poaceae)) seed has been used as a dietary supplement for its therapeutic effects for thousands of years...
  6. Meng X, Huang B, Zhou L, He Y, Chen Q, Yuan Y, et al. Construction of a Coix BAC library and isolation of the 22 kDa α-coixin gene cluster. Genome. 2010;53:667-74 pubmed publisher
    b>Coix lacryma-jobi L. (Coix) is a close relative of maize and is considered a valuable genetic resource for crop improvement...
  7. Leseberg C, Duvall M. The complete chloroplast genome of Coix lacryma-jobi and a comparative molecular evolutionary analysis of plastomes in cereals. J Mol Evol. 2009;69:311-8 pubmed publisher
    ..A complete plastome from Coix lacryma-jobi (Poaceae) and a draft plastome from Joinvillea plicata (Joinvilleaceae) were sequenced and analyzed...
  8. Chung C, Hsia S, Lee M, Chen H, Cheng F, Chan L, et al. Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. J Agric Food Chem. 2011;59:6025-33 pubmed publisher
    Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM)...
  9. Lu H, Jiang P, Hsu L, Chyan C, Tzen J. Characterization of oil bodies in adlay (Coix lachryma-jobi L). Biosci Biotechnol Biochem. 2010;74:1841-7 pubmed
    Oil bodies were observed in cells of both embryo and aleurone layers of mature adlay grains (Coix lachryma-jobi L. var. ma-yuen Stapf). Stable oil bodies were successfully isolated from the adlay grains...

More Information

Publications86

  1. Yu F, Gao J, Zeng Y, Liu C. Inhibition of Coix seed extract on fatty acid synthase, a novel target for anticancer activity. J Ethnopharmacol. 2008;119:252-8 pubmed publisher
    b>Coix seed has been traditionally used to treat cancers in folk medicine.
  2. Woo J, Li D, Wilsbach K, Orita H, Coulter J, Tully E, et al. Coix seed extract, a commonly used treatment for cancer in China, inhibits NFkappaB and protein kinase C signaling. Cancer Biol Ther. 2007;6:2005-11 pubmed
    A pharmaceutical grade extract of Coix lachryma-jobi seeds is currently the most commonly used treatment for cancer in China...
  3. Zhou L, Huang B, Meng X, Wang G, Wang F, Xu Z, et al. The amplification and evolution of orthologous 22-kDa ?-prolamin tandemly arrayed genes in coix, sorghum and maize genomes. Plant Mol Biol. 2010;74:631-43 pubmed publisher
    ..Here, we isolated and sequenced the Coix 22-kDa prolamin (coixin) gene cluster (283 kb), and carried out a comparative analysis with orthologous 22-kDa ..
  4. Chen H, Shih C, Hsu H, Chiang W. Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem. 2010;58:2596-601 pubmed publisher
    ..The purpose of this study was to investigate the effects of adlay (Job's tears, Coix lachryma-jobi L. var...
  5. Zhan Y, Huang X, Cao J, Lu Y, Wu X, Liu J, et al. Clinical safety and efficacy of Kanglaite® (Coix Seed Oil) injection combined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev. 2012;13:5319-21 pubmed
    To observe efficacy and side effects, as well as the impact on quality of life, of Kanglaite® (Coix Seed Oil) injections combined with chemotherapy in the treatment of advanced gastric cancer patiensts.
  6. Yu Y, Lu Y, Tang X, Cui F. Formulation, preparation and evaluation of an intravenous emulsion containing Brucea javanica oil and Coix Seed oil for anti-tumor application. Biol Pharm Bull. 2008;31:673-80 pubmed
    ..of this study was to prepare and evaluate the intravenous emulsion (BCOE) containing Brucea javanica oil (BJO) and Coix seed oil (CSO), which is used in anti-tumor treatment...
  7. Kim S, Yun S, Lee E. The water extract of adlay seed (Coix lachrymajobi var. mayuen) exhibits anti-obesity effects through neuroendocrine modulation. Am J Chin Med. 2007;35:297-308 pubmed
    ..These results suggest that adlay may regulate neuroendocrine activity in the brain. Accordingly, administration of adlay may be considered for therapies targeting obesity...
  8. Qu D, He J, Liu C, Zhou J, Chen Y. Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation. Int J Nanomedicine. 2014;9:109-19 pubmed publisher
    Ganoderma lucidum triterpene-loaded microemulsions (TMEs) using Coix lacryma-jobi (adlay) seed oil as oil phase were prepared, characterized, and evaluated for enhanced antitumor activity...
  9. Hsia S, Chiang W, Kuo Y, Wang P. Downregulation of progesterone biosynthesis in rat granulosa cells by adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) bran extracts. Int J Impot Res. 2006;18:264-74 pubmed
    Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has long been used as a traditional Chinese medicine for dysfunctions of the endocrine system and inflammation conditions...
  10. Lu Y, Zhang B, Jia Z, Wu W, Lu Z. Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi. Hepatobiliary Pancreat Dis Int. 2011;10:303-7 pubmed
    ..In this study, we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis, SC), and monitored the expression of Bcl-2 and caspase-8.
  11. Dong M, Si W, Wang W, Bai B, Nie D, Song W, et al. Determination of type A trichothecenes in coix seed by magnetic solid-phase extraction based on magnetic multi-walled carbon nanotubes coupled with ultra-high performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2016;408:6823-31 pubmed publisher
    ..A trichothecenes including T-2 toxins (T2), HT-2 toxins (HT-2), diacetoxyscirpenol (DAS), and neosolaniol (NEO) in coix seed...
  12. Li S, Huang H, Li Z, Li Z, He Z, Liang H. Chromium removal capability and photosynthetic characteristics of Cyperus alternifolius and Coix lacryma-jobi L. in vertical flow constructed wetland treated with hexavalent chromium bearing domestic sewage. Water Sci Technol. 2017;76:2203-2212 pubmed publisher
    ..Two plants, Cyperus alternifolius (C. alternifolius) and Coix lacryma-jobi L. (C. lacryma-jobi L.) grown in the VFWM enhanced the purification of Cr(VI) enriched domestic sewage...
  13. Yu Y, Chang W, Liu C, Tsai C. Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull. 2004;27:802-5 pubmed
    ..Therefore, supplementation with BL or adlay can decrease plasma lipids and inhibit LDL oxidation in hyperlipidemic smokers and/or non-smokers. ..
  14. Qu D, Wang L, Liu M, Shen S, Li T, Liu Y, et al. Oral Nanomedicine Based on Multicomponent Microemulsions for Drug-Resistant Breast Cancer Treatment. Biomacromolecules. 2017;18:1268-1280 pubmed publisher
    ..The etoposide-loaded ECG-MEs were composed of coix seed oil and ginsenoside Rh2 (G-Rh2), both of which possess not only the synergistic antitumor effect with ..
  15. Chen H, Hsu H, Chiang W. Allergic immune-regulatory effects of adlay bran on an OVA-immunized mice allergic model. Food Chem Toxicol. 2012;50:3808-13 pubmed publisher
    ..These results suggest that adlay bran extract can reduce an allergic reaction by balancing Th1/Th2 immune responses and that it might be used in the treatment of this condition. ..
  16. Hsu H, Lin B, Lin J, Kuo C, Chiang W. Suppression of allergic reactions by dehulled adlay in association with the balance of TH1/TH2 cell responses. J Agric Food Chem. 2003;51:3763-9 pubmed
    ..These results suggest that dehulled adlay has a modulating ability to shift the balance from Th2 to Th1 dominance in the T cell mediated immune system and may be beneficial for the treatment of allergic disorders. ..
  17. Hung W, Chang H. Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. J Agric Food Chem. 2003;51:7333-7 pubmed
    ..Taken together, these results suggest that inhibition of COX-2 is one of the mechanisms by which the methanolic extract of adlay seed inhibits cancer growth and prevents lung tumorigenesis. ..
  18. Huang D, Kuo Y, Lin F, Lin Y, Chiang W. Effect of Adlay ( Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and its phenolic components on Cu2+-treated low-density lipoprotein (LDL) oxidation and lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem. 2009;57:2259-66 pubmed publisher
    ..In conclusion, ATE has antioxidative and anti-inflammatory activities, and its effects are partially related to its phenolic components. Thus, ATE has the potential to be developed as a functional food targeting chronic diseases. ..
  19. Wang D, Yang C, Wang Z, Yang Y, Li D, Ding X, et al. Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation. Sci Rep. 2017;7:9373 pubmed publisher
    ..In this study, we have found that the Norcantharidin (NCTD) + Coix lacryma-jobi seed oil (CLSO) combination exhibited more potent antitumor effects in an terms of cytotoxicity and ..
  20. Kong W, Shen H, Zhang X, Yang X, Qiu F, Ou Yang Z, et al. Analysis of zearalenone and ?-zearalenol in 100 foods and medicinal plants determined by HPLC-FLD and positive confirmation by LC-MS-MS. J Sci Food Agric. 2013;93:1584-90 pubmed publisher
    ..Immunoaffinity clean-up and HPLC-FLD proved to have broad applicability in the field of simultaneously detecting ZON and ?-ZOL in foods and medicinal plants and other complicated matrices. ..
  21. Chang H, Huang Y, Hung W. Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and in vivo. J Agric Food Chem. 2003;51:3656-60 pubmed
    ..Taken together, these results indicate that the components of adlay seed exert an anticancer effect in vitro and in vivo and may be useful for the prevention of lung tumorigenesis. ..
  22. Wang J, Liu L, Ball T, Yu L, Li Y, Xing F. Revealing a 5,000-y-old beer recipe in China. Proc Natl Acad Sci U S A. 2016;113:6444-8 pubmed publisher
    ..a surprising beer recipe in which broomcorn millet (Panicum miliaceum), barley (Hordeum vulgare), Job's tears (Coix lacryma-jobi), and tubers were fermented together...
  23. Chung C, Hsu H, Huang D, Hsu H, Lin J, Shih C, et al. Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway. J Agric Food Chem. 2010;58:7616-23 pubmed publisher
    Adlay ( Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop and was reported to possess anti-inflammatory activity and an antiproliferative effect in cancer cell lines...
  24. Li J, Xiao T, Zhang Q, Dong M. Interactive effect of herbivory and competition on the invasive plant Mikania micrantha. PLoS ONE. 2013;8:e62608 pubmed publisher
    ..To examine this prediction, thus, we conducted an experiment in which both invasive Mikania micrantha and native Coix lacryma-job i were grown together and subjected to herbivory-mimicking defoliation...
  25. Rajesh K, Bharath B, Rao C, Bhat K, Bhat K, Bhat P. Neutralization of Naja naja venom induced lethality, edema and myonecrosis by ethanolic root extract of Coix lacryma-jobi. Toxicol Rep. 2017;4:637-645 pubmed publisher
    i>Coix lacryma-jobi, commonly known as job's tear, is a tall grain-bearing tropical plant of the family Poaceae...
  26. Wang Y, Zhang C, Zhang S, Zhao Z, Wang J, Song J, et al. Kanglaite sensitizes colorectal cancer cells to Taxol via NF-?? inhibition and connexin 43 upregulation. Sci Rep. 2017;7:1280 pubmed publisher
    ..Kanglaite injection is an extract from Coix lacryma-jobi seed and is usually combined with other agents to treat cancer...
  27. Kong W, Li J, Qiu F, Wei J, Xiao X, Zheng Y, et al. Development of a sensitive and reliable high performance liquid chromatography method with fluorescence detection for high-throughput analysis of multi-class mycotoxins in Coix seed. Anal Chim Acta. 2013;799:68-76 pubmed publisher
    As an edible and medicinal plant, Coix seed is readily contaminated by more than one group of mycotoxins resulting in potential risk to human health...
  28. Drobnik J. Chinese vegetative materia medica in a venereological treatise by Jean Astruc from 1740. J Ethnopharmacol. 2016;187:293-301 pubmed publisher
    ..speciosa, Clematis vitalba, Coix lacryma-jobi, Commiphora myrrha, Cydonia oblonga, Daemonorops draco, D...
  29. Li B, Qiao L, Li L, Zhang Y, Li K, Wang L, et al. A Novel Antihypertensive Derived from Adlay (Coix larchryma-jobi L. var. ma-yuen Stapf) Glutelin. Molecules. 2017;22: pubmed publisher
    Our previous studies have shown that Coix glutelin pepsin hydrolysate can effectively inhibit angiotensin converting enzyme (ACE) activity in vitro...
  30. Shi Y, Pan T. Anti-diabetic effects of Monascus purpureus NTU 568 fermented products on streptozotocin-induced diabetic rats. J Agric Food Chem. 2010;58:7634-40 pubmed publisher
    ..A significant reduction was found in urine sugar and urine protein levels. The study scientifically validates the widely claimed use of red-mold-fermented products as an ethnomedicine to treat diabetes mellitus...
  31. Son E, Kim Y, Park C, Park K, Jeong S, Park J, et al. Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. BMC Complement Altern Med. 2017;17:486 pubmed publisher
    b>Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf has been used in China as an herbal medicine. Many studies of this plant have reported anti-proliferative and apoptotic activities on human cancer cell lines...
  32. de Luna M, Flores E, Cenia M, Lu M. Removal of copper ions from aqueous solution by adlai shell (Coix lacryma-jobi L.) adsorbents. Bioresour Technol. 2015;192:841-4 pubmed publisher
    Adlai shell (Coix lacryma-jobi L.) adsorbents (ASA) were used to remove copper ions from aqueous solutions under batch conditions. The effect of physical and chemical modification of ASA on Cu(II) removal was evaluated...
  33. Liu K, Luo T, Zhang Z, Wang T, Kou J, Liu B, et al. Modified Si-Miao-San extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKK?/IRS-1/Akt-dependent pathway. J Ethnopharmacol. 2011;136:473-9 pubmed publisher
    ..The results suggest that mSMS inhibited inflammatory response and improved insulin sensitivity in hepatocytes via an IKK?/IRS-1/Akt-dependent pathway. ..
  34. Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M. Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors. Biol Pharm Bull. 2010;33:854-61 pubmed
    ..This study demonstrated that 11-hydroxy-(9Z)-octadecenoic acid ((9Z)-11-HOE), which was isolated from adlay seeds (Coix lacryma-jobi L. var. ma-yuen STAF...
  35. Pang D, Su X, Zhu Z, Sun J, Li Y, Song Y, et al. Flavonoid dimers from the total phenolic extract of Chinese dragon's blood, the red resin of Dracaena cochinchinensis. Fitoterapia. 2016;115:135-141 pubmed publisher
    ..Compounds 4 and 5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 4.9±0.4 and 5.4±0.6?M, respectively. ..
  36. Chen H, Lo Y, Chiang W. Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. J Ethnopharmacol. 2012;141:119-27 pubmed publisher
    Adlay (Job's tears, Coix lachryma-jobi L. var. ma-yuen Stapf) has long been used in China to treat rheumatism.
  37. Zhao C, He B, Yang Y, Liao J. Dietary therapy of qi-yin-reinforcing porridge for the alleviation of chemotherapy related symptoms of gastrointestinal tumors: a single-case randomized controlled study. Chin J Integr Med. 2013;19:418-23 pubmed publisher
    ..To investigate the efficacy of dietary therapy of qi-yin-reinforcing porridge for the alleviation of clinical symptoms during FOLFOX chemotherapy...
  38. Huang T, Wu W, Li Y, Zhang J, Huang L. [Interventional therapy combining Seed of Job's-stears with lipiodol for hepatoma-bearing rats]. Zhonghua Gan Zang Bing Za Zhi. 2002;10:452-4 pubmed
    ..To study the effect of the interventional therapy of hepatoma-bearing rat by Seed of Job's-stears (SJS) injection combining with lipiodol...
  39. Jiang Y, Zhang Z, Ding D, Sun E, Wang J, Jia X. [Study on porous maize starch preparation and powdering coix seed oil]. Zhongguo Zhong Yao Za Zhi. 2013;38:2287-91 pubmed
    To optimize the preparation conditions of porous starch The porous starch was used to powder coix seed oil. Porous starch was made of maize starch by using compound enzymes of glucoamylase and alpha-amylase...
  40. Qu D, Sun W, Liu M, Liu Y, Zhou J, Chen Y. Bitargeted microemulsions based on coix seed ingredients for enhanced hepatic tumor delivery and synergistic therapy. Int J Pharm. 2016;503:90-101 pubmed publisher
    A hepatic tumor bitargeted microemulsions drug delivery system using coix seed oil and coix seed polysaccharide (CP) acting as anticancer components, as well as functional excipients, was developed for enhanced tumor-specific accumulation ..
  41. Han Y, Wang X, Liu L, Song Y. Comparative physical localization of maize mir1 gene in Zea mays L. and Coix lacryma-jobi L. Yi Chuan Xue Bao. 2004;31:335-9 pubmed
    ..The results of Southern blotting suggested that there were sequences homologous to mir1 in Coix lacryma-jobi L. genome. Then, the sequences were mapped on the distal region of long arm of chromosome 7 in C...
  42. Tseng Y, Yang J, Chang H, Mau J. Taste quality of monascal adlay. J Agric Food Chem. 2004;52:2297-300 pubmed
    ..No flavor 5'-nucleotides were found. On the basis of the results obtained, monascal adlay products might give a bitter perception...
  43. Li S, Chen C, Lin S, Chiang W, Shih C. Effects of adlay bran and its ethanolic extract and residue on preneoplastic lesions of the colon in rats. J Sci Food Agric. 2011;91:547-52 pubmed publisher
    Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a cereal crop used in traditional Chinese medicine and as a nutritious food. Epidemiologists have suspected that the low cancer rates in southeastern China might be related to adlay...
  44. Huang D, Chung C, Kuo Y, Lin Y, Chiang W. Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem. 2009;57:10651-7 pubmed publisher
    ..This is the first time that eriodictyol (1) and this ceramide (2) have been found in AH, and the anti-inflammatory properties of the AHE-Ea fraction can be attributed, at least in part, to the presence of these two compounds...
  45. Huang B, Chiang M, Yao H, Chiang W. The effect of adlay oil on plasma lipids, insulin and leptin in rat. Phytomedicine. 2005;12:433-9 pubmed
    ..Results from this study suggest that dietary adlay oil can reduce leptin, adipose tissue and LDL-C levels in rats...
  46. Li P, Tsai W, Chien C. Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat. Food Chem. 2013;136:765-74 pubmed publisher
  47. Lu Y, Wu L, Dong Q, Li C. Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2. Hepatobiliary Pancreat Dis Int. 2009;8:267-72 pubmed
    ..In this experiment, we examined whether KLT inhibits HepG2 cell growth, if so, tried to explore its mechanism...
  48. Shen X, Wang Z, Yu X. [Mutagenic effects of gamma-rays on Coix lacryma-jobi var. ma-yuen]. Zhongguo Zhong Yao Za Zhi. 2007;32:1016-8 pubmed
    To study the mutagenic effect of gamma-rays on Coix lacryma-jobi var. ma-yuen.
  49. Apirattananusorn S, Tongta S, Cui S, Wang Q. Chemical, molecular, and structural characterization of alkali extractable nonstarch polysaccharides from Job's tears. J Agric Food Chem. 2008;56:8549-57 pubmed publisher
    The polished Job's tears ( Coix lachryma-jobi L.) seeds, dark and white husk types, were sequentially extracted by hot water (75 degrees C) and 0.5 M NaOH solution...
  50. Kim H, Song H, Davaatseren M, Chang H, Chun H. Endoplasmic reticulum stress induced by an ethanol extract of Coicis semen in Chang liver cells. BMC Complement Altern Med. 2018;18:100 pubmed publisher
    ..CSE or coixol may have cytotoxic effect to Chang liver cells and, may induce ER stress and stimulate the UPR via activation of the PERK and IRE1 pathways in normal liver cells. ..
  51. Li G, Peng J, Gao W, Li R, Zhao J, Wang Z. [Identification of disease resistance to Ustilago coicis in southern Coix germplasm]. Zhongguo Zhong Yao Za Zhi. 2010;35:2950-3 pubmed
    To identified the resistance of Coix to Ustilago coicis and screen the high disease-resistance Coix germplasm.
  52. Han X, Ji X, Zhao H, Zhang Y, Liu G, Wang Y, et al. MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG. Afr J Tradit Complement Altern Med. 2017;14:239-246 pubmed publisher
    b>Coix seed has the functions of fortifying the spleen and inhibiting the dampness. However, it remains unclear which Coix seed compositions is responsible for these functions...
  53. Bao Y, Yuan Y, Xia L, Jiang H, Wu W, Zhang X. Neutral lipid isolated from endosperm of Job's tears inhibits the growth of pancreatic cancer cells via apoptosis, G2/M arrest, and regulation of gene expression. J Gastroenterol Hepatol. 2005;20:1046-53 pubmed
    ..The present study was designed to examine its antiproliferative effects in the PaTu-8988 and SW1990 human pancreatic cancer cells and to investigate its potential mechanism(s)...
  54. Dallas S, Ho G. Subsurface flow reedbeds using alternative media for the treatment of domestic greywater in Monteverde, Costa Rica, Central America. Water Sci Technol. 2005;51:119-28 pubmed
    ..33 and 2.67 cm/day and hydraulic retention times (HRT) ranged from 3.5 to 7.5 days. The six reedbeds planted with Coix lacryma-jobi proved to be significantly more effective in pathogen removal and BOD reduction than the unplanted ..
  55. Byun A, Kwon S, Kim S. Administration of Herbal Complexes, Dangguijakyak-san (TJ-23) and Coix Seeds, for Treating Verruca Planae: A Case Report. Explore (NY). 2016;12:65-7 pubmed publisher
    ..and was subsequently treated with Dangguijakyak-san (TJ-23; Tsumura, Japan; and Tokishakuyakusan in Japanese) and coix seed tablets with favorable outcomes...
  56. Yeh P, Chiang W, Chiang M. Effects of dehulled adlay on plasma glucose and lipid concentrations in streptozotocin-induced diabetic rats fed a diet enriched in cholesterol. Int J Vitam Nutr Res. 2006;76:299-305 pubmed
    Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a cereal food for humans and has been also used as a superior medical herb substance and functional food for traditional treatment of diabetes in China...
  57. Chen H, Chen Y, Huang Y, Tsai H, Kuo C. 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med. 2012;52:1054-66 pubmed publisher
    ..4-Ketopinoresinol (4-KPR), the (?-?) double-cyclized type of lignan obtained from adlay (Coix lachryma-jobi L. var...
  58. Lee M, Lin H, Cheng F, Chiang W, Kuo Y. Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran. Food Chem Toxicol. 2008;46:1933-9 pubmed publisher
    Five active compounds that inhibit cancer cells were isolated from adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf), and their structures and activities in vitro were characterized...
  59. Yoza K, Nakamura S, Yaguchi M, Haraguchi K, Ohtsubo K. Molecular cloning and functional expression of cDNA encoding a cysteine proteinase inhibitor, cystatin, from Job's tears (Coix lacryma-jobi L. var. Ma-yuen Stapf). Biosci Biotechnol Biochem. 2002;66:2287-91 pubmed
    ..The cystatin cDNA was expressed in Escherichia coli as a His-tagged recombinant protein. The purified recombinant protein inhibited papain...
  60. Lu X, Liu W, Luo C. [Apoptotic effect of coix polysaccharides on A549 lung cancer cells in vitro]. Zhongguo Fei Ai Za Zhi. 2012;15:624-9 pubmed publisher
    b>Coix seeds are commonly used in Traditional Chinese Medicine and ingested through daily diet. The aim of this study is to analyze the apoptotic effect of coix polysaccharides on A549 cells...
  61. Xiang Z, Zhu M, Chen B, Chen Y. [Identification of triacylglycerols in coix oil by high performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry]. Zhongguo Zhong Yao Za Zhi. 2005;30:1436-8 pubmed
    To identify triacylglycerols in coix oil.
  62. Yao G, Zhang G, Luan J, Ye D, Yan J, Zhu P, et al. [Coix lachryma jobi L varma-yuan induces apoptosis of jurkat cell line in acute T lymphoblast leukemia and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:879-82 pubmed
    The aim of the present study was to investigate the anti-proliferation and pro-apoptosis effect of Coix lachrymajobi L varma-yuan on acute T lymphoblast leukemia cell line Jurkat cells and its mechanism...
  63. Kim J, Shin J, Lee S. Cardioprotective effects of diet with different grains on lipid profiles and antioxidative system in obesity-induced rats. Int J Vitam Nutr Res. 2012;82:85-93 pubmed publisher
    ..This effect was related to several mechanisms that corresponded to lowering plasma lipids, decreasing TBARS, and increasing antioxidant activities...
  64. Wang L, Sun J, Yi Q, Wang X, Ju X. Protective effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on hypercholesterolemia-induced oxidative stress in rats. Molecules. 2012;17:8886-97 pubmed publisher
    The present study examines the effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) (APE) on high cholesterol diet fed rats (HCD)...
  65. Chung C, Hsu C, Lin J, Kuo Y, Chiang W, Lin Y. Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines. J Agric Food Chem. 2011;59:1185-94 pubmed publisher
    ..4, 25.3, and 69.3%, respectively. In conclusion, ABE has antiproliferative activities, and this effect is partially related to the presence of lactams and spiroenone...
  66. Han Y, Qi C, She C, Liu L, Song Y. Physical mapping of the 45S and 5S rDNA in Coix lacryma-jobi L. Shi Yan Sheng Wu Xue Bao. 2003;36:393-6 pubmed
  67. Peng J, Gao W, Peng C, He C, Zhang Q, Bi W. [Characteristics of germplasm resources in Coix from xishuangbanna]. Zhongguo Zhong Yao Za Zhi. 2010;35:415-8 pubmed
    To evaluate the genetic diversity among wild germplasm resources of Coix that distributed at altitude of 550-1550 m in Xishuangbanna, Yunnan province by comparing the morphological variation, biological and economical factors.
  68. Zhao Y, Wang Y, Yang J, Liu D. [A study on the rotation of crops among Panax quinquefolium, Perilla frutescens and Coix lacryma-jobi]. Zhongguo Zhong Yao Za Zhi. 2005;30:12-5 pubmed
    ..To provide evidence for establishing an efficient method of growing Panax quinquefolium by rotation of crops...
  69. Dong Q, Zhong X, Zheng S. [Effect of Kanglaite injection oncyclooxygenase activity in lung carcinoma A549 cell]. Zhongguo Zhong Yao Za Zhi. 2005;30:1621-3, 1633 pubmed
    ..To study the effect of Kanglaite injection on cyclooxygenase activity in lung carcinoma A549 cells...
  70. Hu A, Zhao S, Liang H, Qiu T, Chen G. Ultrasound assisted supercritical fluid extraction of oil and coixenolide from adlay seed. Ultrason Sonochem. 2007;14:219-24 pubmed
    Oil and coixenolide are important components of adlay seed (Coix lachrymal-jobi L. var. Adlay) with many beneficial functions to human health...
  71. Wang L, Chen J, Xie H, Ju X, Liu R. Phytochemical profiles and antioxidant activity of adlay varieties. J Agric Food Chem. 2013;61:5103-13 pubmed publisher
    ..Knowing the phytochemical profiles and antioxidant activity of adlay gives insights to its potential application to promote health. ..
  72. Hsia S, Yeh C, Kuo Y, Wang P, Chiang W. Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro. Exp Biol Med (Maywood). 2007;232:1181-94 pubmed
    Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has been used as a traditional Chinese medicine for dysfunction of the endocrine system. However, there have been few studies on the effects of adlay seed on the endocrine system...
  73. Xi X, Zhu Y, Tong Y, Yang X, Tang N, Ma S, et al. Assessment of the Genetic Diversity of Different Job's Tears (Coix lacryma-jobi L.) Accessions and the Active Composition and Anticancer Effect of Its Seed Oil. PLoS ONE. 2016;11:e0153269 pubmed publisher
    Job's tears (Coix lachryma-jobi L.) is an important crop used as food and herbal medicine in Asian countries. A drug made of Job's tears seed oil has been clinically applied to treat multiple cancers...
  74. Shih C, Chiang W, Kuo M. Effects of adlay on azoxymethane-induced colon carcinogenesis in rats. Food Chem Toxicol. 2004;42:1339-47 pubmed
    Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop used in traditional Chinese medicine and as a nutritious food. It has been reported that adlay has anti-inflammatory and anti-tumor activity...
  75. Xiong J, Qin Y, Mahmood Q, Liu H, Yang D. Phosphorus removal from secondary effluents through integrated constructed treatment system. Mar Pollut Bull. 2011;63:98-101 pubmed publisher
    ..45% after 40 days of operation, the average DP and TP removal efficiencies of the integrated CTS were 97.43% and 96.40%, respectively. The integrated CTS has good potential in removing COD as well as P from secondary effluents...
  76. Yokoi H, Mizukami H, Nagatsu A, Ohno T, Tanabe H, Inoue M. Peroxisome proliferator-activated receptor gamma ligands isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.). Biol Pharm Bull. 2009;32:735-40 pubmed
    ..using the PPARgamma luciferase reporter assay, 6 hydroxy unsaturated fatty acids were isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.) extracts with acetone and 70% ethanol...
  77. Hu Y, Liang H, Gong W, Xu Z, Zou Q. [The effect of kanglaite injection(KLT) on the proliferation and telomerase activity of rat mesangial cells]. Zhongguo Zhong Yao Za Zhi. 2005;30:450-3 pubmed
    ..To observe the effect of Kanglaite injection(KLT) on the proliferation and telomerase activity of mesangial cells in rats...