piper nigrum

Summary

Summary: A plant species in the PIPERACEAE plant family. It is a common spice on foods and is used medicinally to increase gastrointestinal assimilation of other supplements and drugs. Piperine is a key component. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water.

Top Publications

  1. Kanaki N, Dave M, Padh H, Rajani M. A rapid method for isolation of piperine from the fruits of Piper nigrum Linn. J Nat Med. 2008;62:281-3 pubmed publisher
    A simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The method involves extraction of the fruit powder with glacial acetic acid, from which piperine is partitioned into ..
  2. Siddiqui B, Gulzar T, Begum S, Afshan F. Piptigrine, a new insecticidal amide from Piper nigrum Linn. Nat Prod Res. 2004;18:473-7 pubmed
    ..amide piptigrine (1) possessing highly extended conjugation was isolated from the dried ground seeds of Piper nigrum Linn. along with the known amides piperine and wisanine (hitherto unreported from this plant)...
  3. Vijayakumar R, Surya D, Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 2004;9:105-10 pubmed
    The present study was aimed to explore the effect of black pepper (Piper nigrum L.) on tissue lipid peroxidation, enzymic and non-enzymic antioxidants in rats fed a high-fat diet...
  4. Lin Z, Liao Y, Venkatasamy R, Hider R, Soumyanath A. Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro. J Pharm Pharmacol. 2007;59:529-36 pubmed
    ..b>Piper nigrum L...
  5. Barbieri E, Barreto C, Ribeiro R, de Oliveira V, Freire de Lima M, Moya Borja G. [Insecticide effects of natural amides from Piper and of the synthetic derivative tetrahydropiperine on Lucilia cuprina (Diptera: Calliphoridae) and Musca domestica (Diptera: Muscidae)]. Rev Bras Parasitol Vet. 2007;16:87-91 pubmed
    ..03 and 6.57 microg/fly, respectively. Males of L. cuprina were more resistant to tetrahydropiperine than females. However females of M. domestica were more resistant to the insecticide than males...
  6. Park I, Lee S, Shin S, Park J, Ahn Y. Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species. J Agric Food Chem. 2002;50:1866-70 pubmed
    The insecticidal activity of materials derived from the fruits of Piper nigrum against third instar larvae of Culex pipiens pallens, Aedes aegypti, and A...
  7. Ee G, Lim C, Rahmani M, Shaari K, Bong C. Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum. Molecules. 2010;15:2398-404 pubmed publisher
    Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines...
  8. Ahmed H, Salem A, Sabry G, Husein A, Kotob S. Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's disease-induced rats. J Med Food. 2013;16:437-46 pubmed publisher
    This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model...
  9. Jensen H, Scott I, Sims S, Trudeau V, Arnason J. Gene expression profiles of Drosophila melanogaster exposed to an insecticidal extract of Piper nigrum. J Agric Food Chem. 2006;54:1289-95 pubmed
    Black pepper, Piper nigrum L. (Piperaceae), has insecticidal properties and could potentially be utilized as an alternative to synthetic insecticides. Piperine extracted from P...

More Information

Publications93

  1. Liu Y, Yadev V, Aggarwal B, Nair M. Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Nat Prod Commun. 2010;5:1253-7 pubmed
    Black pepper (Piper nigrum) and hot pepper (Capsicum spp.) are widely used in traditional medicines. Although hot Capsicum spp...
  2. Majdalawieh A, Carr R. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food. 2010;13:371-81 pubmed publisher
    ..We anticipate that black pepper and cardamom constituents can be used as potential therapeutic tools to regulate inflammatory responses and prevent/attenuate carcinogenesis...
  3. Kapoor I, Singh B, Singh G, de Heluani C, De Lampasona M, Catalan C. Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum). J Agric Food Chem. 2009;57:5358-64 pubmed publisher
    Essential oil and oleoresins (ethanol and ethyl acetate) of Piper nigrum were extracted by using Clevenger and Soxhlet apparatus, respectively...
  4. Jensen H, Scott I, Sims S, Trudeau V, Arnason J. The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster. Insect Mol Biol. 2006;15:329-39 pubmed
    An ethyl acetate extract of Piper nigrum L. (Piperaceae) peppercorns was tested as a synergist for the botanical insecticide pyrethrum. A high synergist ratio of 11...
  5. Matsuda H, Kawaguchi Y, Yamazaki M, Hirata N, Naruto S, Asanuma Y, et al. Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents. Biol Pharm Bull. 2004;27:1611-6 pubmed
    A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells...
  6. Orav A, Stulova I, Kailas T, Muurisepp M. Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states. J Agric Food Chem. 2004;52:2582-6 pubmed
    ..Differently from other pepper samples, 1 year storage of green pepper corn raised the oil amount more than twice of both drying methods...
  7. Rahman S, Parvez A, Islam R, Khan M. Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh. Ann Clin Microbiol Antimicrob. 2011;10:10 pubmed publisher
    ..The present work aimed to find out the antimicrobial activity of natural spices on multi-drug resistant Escherichia coli isolates...
  8. Wei K, Li W, Koike K, Chen Y, Nikaido T. Nigramides A-S, dimeric amide alkaloids from the roots of Piper nigrum. J Org Chem. 2005;70:1164-76 pubmed
    ..amide alkaloids possessing a cyclobutane ring, nigramides P-S (17-20), have been isolated from the roots of Piper nigrum. Their structures were elucidated on the basis of their spectroscopic data...
  9. Aravind R, Kumar A, Eapen S, Ramana K. Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici. Lett Appl Microbiol. 2009;48:58-64 pubmed publisher
    To isolate and identify black pepper (Piper nigrum L) associated endophytic bacteria antagonistic to Phytophthora capsici causing foot rot disease.
  10. Subehan -, Usia T, Kadota S, Tezuka Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med. 2006;72:527-32 pubmed
    Nineteen alkamides isolated from Piper nigrum L. were tested for their mechanism-based inhibition on human liver microsomal dextromethorphan O-demethylation activity, a prototype marker for cytochrome P450 2D6 (CYP2D6)...
  11. Ahmad N, Abbasi B, Rahman I, Fazal H. Piper nigrum: micropropagation, antioxidative enzyme activities, and chromatographic fingerprint analysis for quality control. Appl Biochem Biotechnol. 2013;169:2004-15 pubmed publisher
    A reliable in vitro regeneration system for the economical and medicinally important Piper nigrum L. has been established...
  12. Tan L, Yin W, Chan K. Piper nigrum, Piper betle and Gnetum gnemon--natural food sources with anti-quorum sensing properties. Sensors (Basel). 2013;13:3975-85 pubmed publisher
    Various parts of Piper nigrum, Piper betle and Gnetum gnemon are used as food sources by Malaysians. The purpose of this study is to examine the anti-quorum sensing (anti-QS) properties of P. nigrum, P. betle and G. gnemon extracts...
  13. Rho M, Lee S, Park H, Choi J, Kang J, Kim K, et al. ACAT inhibition of alkamides identified in the fruits of Piper nigrum. Phytochemistry. 2007;68:899-903 pubmed
    In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated...
  14. Zaugg J, Baburin I, Strommer B, Kim H, Hering S, Hamburger M. HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site. J Nat Prod. 2010;73:185-91 pubmed publisher
    ..An ethyl acetate extract of black pepper fruits [Piper nigrum L...
  15. Kaleem M, Sheema -, Sarmad H, Bano B. Protective effects of Piper nigrum and Vinca rosea in alloxan induced diabetic rats. Indian J Physiol Pharmacol. 2005;49:65-71 pubmed
    In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administered orally to alloxan induced diabetic rats once a day for 4 weeks...
  16. Li S, Lei Y, Jia Y, Li N, Wink M, Ma Y. Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells. Phytomedicine. 2011;19:83-7 pubmed publisher
    ..These results suggest that piperine can reverse MDR by multiple mechanisms and it may be a promising lead compound for future studies...
  17. Lee S, Kim Y, Kim K, Lee H, Choi J, Lee W, et al. Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008;18:4544-6 pubmed publisher
    ..Their compounds 3-5, 7, and 8 inhibited potently the direct binding between sICAM-1 and LFA-1 of THP-1 cells in a dose-dependent manner, with IC(50) values of 10.7, 8.8, 13.4, 13.5, and 6.0 microg/mL, respectively...
  18. Chang Y, Lee S, Na J, Chang P, Han J. Protection of Grain Products from Sitophilus oryzae (L.) Contamination by Anti-Insect Pest Repellent Sachet Containing Allyl Mercaptan Microcapsule. J Food Sci. 2017;82:2634-2642 pubmed publisher
    ..activities of essential oils (EOs) from garlic (Allium Sativum), ginger (Zingiber Officinalis), black pepper (Piper nigrum), onion (Allium cepa), and fennel (Foeniculum vulgare) as well as major compounds (allyl disulfide, AD; allyl ..
  19. Jalili M, Jinap S, Son R. The effect of chemical treatment on reduction of aflatoxins and ochratoxin A in black and white pepper during washing. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:485-93 pubmed publisher
    ..5% ± 2.7% using benzoic acid and 54.5% ± 2.7% using sodium hydroxide. There was no significant difference between black and white peppers (p < 0.05). ..
  20. Verma A, Kushwaha H, Srivastava A, Srivastava S, Jamal N, Srivastava K, et al. Piperine attenuates UV-R induced cell damage in human keratinocytes via NF-kB, Bax/Bcl-2 pathway: An application for photoprotection. J Photochem Photobiol B. 2017;172:139-148 pubmed publisher
    ..Piperine (PIP), as a plant alkaloid, is an important constituent present in black pepper (Piper nigrum), used widely in ayurvedic and other traditional medicines and has broad pharmacological properties...
  21. Jin C, Jia Y, Dong H, Zhou J, Sun G, Zhang Y, et al. Stir-fried white pepper can treat diarrhea in infants and children efficiently: a randomized controlled trial. Am J Chin Med. 2013;41:765-72 pubmed publisher
    ..5 years with diarrhea compared to treatment with montmorillonite powder, especially for the patients with acute diarrhea or persistent diarrhea. ..
  22. Howshigan J, Perera K, Samita S, Rajapakse P. The effects of an Ayurvedic medicinal toothpaste on clinical, microbiological and oral hygiene parameters in patients with chronic gingivitis: a double-blind, randomised, placebo-controlled, parallel allocation clinical trial. Ceylon Med J. 2015;60:126-32 pubmed publisher
    ..Acacia chundra Willd, Adhatoda vasica Nees., Mimusops elengi L., Piper nigrum L., Pongamia pinnate L. Pirerre, Quercus infectoria Olivier., Syzygium aromaticum L., Terminalia chebula Retz...
  23. Lee S, Rho M, Park H, Choi J, Kang J, Lee J, et al. Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum. J Agric Food Chem. 2006;54:9759-63 pubmed
    ..8 (2), 37.2 (3), 20.1 (4), and 21.2 (5) microM, respectively, but the IC50 value for 1 was more than 900 microM. This finding indicates that compounds possessing piperidine groups (2-5) can be potential DGAT inhibitors. ..
  24. Yan G, Zhu C, Luo Y, Yang Y, Wei J. [Potential allelopathic effects of Piper nigrum, Mangifera indica and Clausena lansium]. Ying Yong Sheng Tai Xue Bao. 2006;17:1633-6 pubmed
    With Piper nigrum, Mangifera indica and Clausena lansium as the donators, this paper studied their potential allelopathic effects on the germination and growth of Zea mays, Glycine max, Cucurbita moschata, Arachis hypogaea, Raphanus ..
  25. Krchnak V, Zajicek J, Miller P, Miller M. Selective molecular sequestration with concurrent natural product functionalization and derivatization: from crude natural product extracts to a single natural product derivative in one step. J Org Chem. 2011;76:10249-53 pubmed publisher
    ..Several plants, including Piper nigrum, Eugenia caryophyllata, and Pimenta dioica, were extracted with organic solvent in the presence of a nitroso-..
  26. Khaliq T, Sarfraz M, Ashraf M. Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes. West Indian Med J. 2015;64:527-532 pubmed publisher
    ..i>Curcuma longa,a spice, is commonly known as turmeric and belongs to the family Zingiberaceae. Piper nigrumis also a spice, commonly called black pepper, and belongs to the family Piperaceae...
  27. Deng Y, Sriwiriyajan S, Tedasen A, Hiransai P, Graidist P. Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro. J Ethnopharmacol. 2016;188:87-95 pubmed publisher
    b>Piper nigrum is widely used as a folk medicine including usage for pain relief, fevers, as well as an anti-cancer agent. However the crude extract of piperine free P...
  28. Wei K, Dou D, Pei Y, Chen Y. [Comparison of the chemical constituents and pharmacological action of Piper nigrum Linn. with P. methysticum forst]. Zhongguo Zhong Yao Za Zhi. 2002;27:328-33 pubmed
  29. Al Jasass F, Al Jasser M. Chemical composition and fatty acid content of some spices and herbs under Saudi Arabia conditions. ScientificWorldJournal. 2012;2012:859892 pubmed publisher
    ..The differences in the results obtained are due to environmental factors, production areas, cultivars used to produce seeds and also due to the different methods used to prepare these local spices. ..
  30. Mahdy K, Shaker O, Wafay H, Nassar Y, Hassan H, Hussein A. Effect of some medicinal plant extracts on the oxidative stress status in Alzheimer's disease induced in rats. Eur Rev Med Pharmacol Sci. 2012;16 Suppl 3:31-42 pubmed
    ..The present study aims to investigate the effect of Salvia triloba and Piper nigrum plant extracts on the oxidative stress status in Alzheimer's disease induced in rats...
  31. Figueroa Lopez K, Andrade Mahecha M, Torres Vargas O. Development of Antimicrobial Biocomposite Films to Preserve the Quality of Bread. Molecules. 2018;23: pubmed publisher
    ..Clove (Syzygium aromaticum), nutmeg (Myristica fragrans), and black pepper (Piper nigrum) oleoresins containing antimicrobial compounds of natural origin were incorporated into the films...
  32. Ngamo L, Ngassoum M, Jirovetz L, Ousman A, Nukenine E, Mukala O. Protection of stored maize against Sitophilus zeamais (Motsch.) by use of essential oils of spices from Cameroon. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2001;66:473-8 pubmed
    ..Lamiaceae) 74% after 4 days after ingestion. Piper nigrum (L.) (Piperaceae) killing more than 96% of weevil 48 hours after the contact...
  33. Wei K, Li W, Koike K, Pei Y, Chen Y, Nikaido T. New amide alkaloids from the roots of Piper nigrum. J Nat Prod. 2004;67:1005-9 pubmed
    ..and 1-[1-oxo-5(3,4-methylenedioxyphenyl)-2Z,4E-pentadienyl]pyrrolidine (7), were isolated from the roots of Piper nigrum, together with 32 known amides...
  34. Tammina S, Mandal B, Ranjan S, Dasgupta N. Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines. J Photochem Photobiol B. 2017;166:158-168 pubmed publisher
    Different sized tetragonal tin oxide nanoparticles (SnO2 NPs) were synthesized using Piper nigrum seed extract at three different calcination temperatures (300, 500, 900°C) and these nanoparticles (NPs) were characterized by ..
  35. Gu F, Huang F, Wu G, Zhu H. Contribution of Polyphenol Oxidation, Chlorophyll and Vitamin C Degradation to the Blackening of Piper nigrum L. Molecules. 2018;23: pubmed publisher
    Black pepper (Piper nigrum L.) is the most widely used spice in the world. Blackening is considered to be beneficial and important in the processing of black pepper because it contributes to its color and flavor...
  36. Margaria P, Ciuffo M, Pacifico D, Turina M. Evidence that the nonstructural protein of Tomato spotted wilt virus is the avirulence determinant in the interaction with resistant pepper carrying the TSW gene. Mol Plant Microbe Interact. 2007;20:547-58 pubmed
    ..Analysis of another RB strain phenotype allowed us to conclude that local necrotic response is not sufficient for resistance in Capsicum spp. carrying the Tsw gene. ..
  37. Hao C, Xia Z, Fan R, Tan L, Hu L, Wu B, et al. De novo transcriptome sequencing of black pepper (Piper nigrum L.) and an analysis of genes involved in phenylpropanoid metabolism in response to Phytophthora capsici. BMC Genomics. 2016;17:822 pubmed
    b>Piper nigrum L., or "black pepper", is an economically important spice crop in tropical regions...
  38. Nascimento S, Lima A, Borges B, De Souza C. Endophytic bacteria from Piper tuberculatum Jacq.: isolation, molecular characterization, and in vitro screening for the control of Fusarium solani f. sp piperis, the causal agent of root rot disease in black pepper (Piper nigrum L.). Genet Mol Res. 2015;14:7567-77 pubmed publisher
    ..sp piperis, the causal agent of black pepper (Piper nigrum) root rot disease in the Amazon region...
  39. Hou Y, Zhou B, Wu X, Fu Y, Wang Y. [Allelopathy of decomposing pepper stalk on pepper growth]. Ying Yong Sheng Tai Xue Bao. 2006;17:699-702 pubmed
    ..The allelopathic effects of decomposed pepper stalk on the physiological indices of pepper root activity ranged from 0.0163 to 0.6507, which was significantly higher than that of plant growth index. ..
  40. Tak J, Lee J, Park J. Resveratrol and piperine enhance radiosensitivity of tumor cells. BMB Rep. 2012;45:242-6 pubmed
    ..Applying natural products as sensitizers for IR-induced apoptotic cell death offers a promising therapeutic approach to treat cancer. ..
  41. Zheng J, Zhou Y, Li Y, Xu D, Li S, Li H. Spices for Prevention and Treatment of Cancers. Nutrients. 2016;8: pubmed publisher
    ..Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such ..
  42. Morales A, Ruiz I, Oliva J, Barba A. Determination of sixteen pesticides in peppers using high-performance liquid chromatography/mass spectrometry. J Environ Sci Health B. 2011;46:525-9 pubmed publisher
    ..A linear dynamic range was obtained over a range of concentrations from 10 to 100 ?g kg?¹ for each of the analytes, with correlation coefficients >0.997. ..
  43. Zhang H, Matsuda H, Nakamura S, Yoshikawa M. Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells. Bioorg Med Chem Lett. 2008;18:3272-7 pubmed publisher
  44. Bell C, Atkinson H, Andrade A, Nguyên H, Swibawa I, Lilley C, et al. A high throughput molecular pipeline reveals the diversity in prevalence and abundance of Pratylenchus and Meloidogyne species in coffee plantations. Phytopathology. 2018;: pubmed publisher
    ..canephora) and its intercropped species Musa acuminata (banana) and Piper nigrum (black pepper). Pratylenchus coffeae and P...
  45. Chavarria D, Silva T, Magalhães e Silva D, Remião F, Borges F. Lessons from black pepper: piperine and derivatives thereof. Expert Opin Ther Pat. 2016;26:245-64 pubmed publisher
    Piperine is a simple and pungent alkaloid found in the seeds of black pepper (Piper nigrum)...
  46. Ferrer C, Mezcua M, Martínez Uroz M, Pareja L, Lozano A, Fernandez Alba A. Method development and validation for determination of thiosultap sodium, thiocyclam, and nereistoxin in pepper matrix. Anal Bioanal Chem. 2010;398:2299-306 pubmed publisher
    ..Stability studies of thiosultap sodium in water were performed by evaluating a 100-?g?l(-1) solution of this compound in water. It was analyzed over 7 days, after which more than 80% degradation of thiosultap sodium could be observed. ..
  47. Prakash U, Srinivasan K. Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats. Br J Nutr. 2010;104:31-9 pubmed publisher
  48. Mani A, Vasanthi C, Gopal V, Chellathai D. Role of phyto-stabilised silver nanoparticles in suppressing adjuvant induced arthritis in rats. Int Immunopharmacol. 2016;41:17-23 pubmed publisher
    The present study was aimed to evaluate the anti-arthritic effects of silver nanoparticles synthesised using Piper nigrum extract and to further establish its mechanism of action in a rat model of adjuvant induced arthritis (AA)...
  49. Park I. Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti. Nat Prod Res. 2012;26:2129-31 pubmed publisher
    The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes ..
  50. Zhang J, Wang Y, Pan D, Cao J, Shao X, Chen Y, et al. Effect of black pepper essential oil on the quality of fresh pork during storage. Meat Sci. 2016;117:130-6 pubmed publisher
    ..The lower TVB-N value of BPEO treatments than the control could be attributed to the inhibition of Pseudomonas spp. and Enterobacteriaceae. Gram-negative bacteria were more sensitive than Gram-positive bacteria to BPEO. ..
  51. Siddiqui B, Gulzar T, Begum S, Afshan F, Sattar F. Insecticidal amides from fruits of Piper nigrum Linn. Nat Prod Res. 2005;19:143-50 pubmed
    The petroleum ether and ethyl acetate fractions of dried ground seeds of Piper nigrum Linn...
  52. Sriwiriyajan S, Tedasen A, Lailerd N, Boonyaphiphat P, Nitiruangjarat A, Deng Y, et al. Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrum Extract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats. Cancer Prev Res (Phila). 2016;9:74-82 pubmed publisher
    b>Piper nigrum (P. nigrum) is commonly used in traditional medicine. This current study aimed to investigate the anticancer and cancer preventive activity of a piperine-free P...
  53. Liu H, Zeng F, Wang Q, Ou S, Tan L, Gu F. The effect of cryogenic grinding and hammer milling on the flavour quality of ground pepper (Piper nigrum L.). Food Chem. 2013;141:3402-8 pubmed publisher
    ..However, we found that the flavour quality of ground pepper was reduced during storage...
  54. Tsukamoto S, Tomise K, Miyakawa K, Cha B, Abe T, Hamada T, et al. CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper. Bioorg Med Chem. 2002;10:2981-5 pubmed
    ..E, were isolated as inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from the white pepper, Piper nigrum. Their structures were elucidated by spectroscopic methods...
  55. Al Baghdadi O, Prater N, Van der Schyf C, Geldenhuys W. Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease. Bioorg Med Chem Lett. 2012;22:7183-8 pubmed publisher
    ..Piperine is an alkaloid from the source plant of both black and white pepper grains, Piper nigrum. Piperine has been shown to have a wide range of activity, including MAO inhibitory activity...
  56. Gobena D, Roig J, Galmarini C, Hulvey J, Lamour K. Genetic diversity of Phytophthora capsici isolates from pepper and pumpkin in Argentina. Mycologia. 2012;104:102-7 pubmed publisher
    ..capsici in Argentina. The implications for breeding resistant peppers and overall disease management are discussed...
  57. Hlavackova L, Urbanova A, Ulicna O, Janega P, Cerna A, Babal P. Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition. Bratisl Lek Listy. 2010;111:426-31 pubmed
    ..The presented study is aimed on exploring the effects of black pepper on blood pressure in the rat model of experimental hypertension induced by chronic NO synthesis inhibition...
  58. Kirchberg J, Büttner D, Thiemer B, Sawers R. Aconitase B is required for optimal growth of Xanthomonas campestris pv. vesicatoria in pepper plants. PLoS ONE. 2012;7:e34941 pubmed publisher
    ..We therefore propose that optimal growth and survival of Xcv in pepper plants depends on AcnB, which might be required for the utilization of citrate as carbon source and could also help protect the bacterium against oxidative stress...
  59. Siddiqui B, Gulzar T, Begum S, Afshan F, Sultana R. A new natural product and insecticidal amides from seeds of Piper nigrum Linn. Nat Prod Res. 2008;22:1107-11 pubmed publisher
    Studies on the petroleum ether soluble and insoluble fraction of ethanol extract of dried ground seeds of Piper nigrum resulted in the isolation and structure elucidation of 1 new and 11 known compounds which include 3 hitherto unreported ..
  60. Rentería Canett I, Xoconostle Cazares B, Ruiz Medrano R, Rivera Bustamante R. Geminivirus mixed infection on pepper plants: synergistic interaction between PHYVV and PepGMV. Virol J. 2011;8:104 pubmed publisher
    ..These include analyses of symptom severity, viral DNA concentration and tissue localization of both viruses in single and mixed infections...
  61. Joy N, Prasanth V, Soniya E. Microsatellite based analysis of genetic diversity of popular black pepper genotypes in South India. Genetica. 2011;139:1033-43 pubmed publisher
    ..The study was first to portray the precise genetic relatedness among the major indigenous genotypes of black pepper...
  62. Naseri M, Yahyavi H. Antispasmodic effect of Piper nigrum fruit hot water extract on rat ileum. Pak J Biol Sci. 2008;11:1492-6 pubmed
    ..The extract spasmolytic effect was attenuated neither by glibenclamide (10 microM) nor by tetraethylammonium (1 mM). Present results suggest that the spasmolytic effect of the extract on rat ileum was possibly mediated via Ca2+ influx...
  63. Venkatesh S, Durga K, Padmavathi Y, Reddy B, Mullangi R. Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics. Arzneimittelforschung. 2011;61:506-9 pubmed publisher
    Piperine (CAS 94-62-2), an alkaloid obtained from Piper nigrum and P. longum, is a known inhibitor of various enzymes (CYP isozymes) responsible for biotransformation of drugs...
  64. Iqbal G, Iqbal A, Mahboob A, Farhat S, Ahmed T. Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine. Curr Pharm Biotechnol. 2016;17:962-73 pubmed
    Black pepper (Piper nigrum Linn.) has vital pharmacological properties with profound effects on central nervous system...
  65. Reddy S, Srinivas P, Praveen B, Kishore K, Raju B, Murthy U, et al. Antibacterial constituents from the berries of Piper nigrum. Phytomedicine. 2004;11:697-700 pubmed
    b>Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P...
  66. Bhat A, Siljo A, Deeshma K. Rapid detection of Piper yellow mottle virus and Cucumber mosaic virus infecting black pepper (Piper nigrum) by loop-mediated isothermal amplification (LAMP). J Virol Methods. 2013;193:190-6 pubmed publisher
    ..The optimal conditions arrived at were validated by testing field samples of infected vines of three species from different regions. ..
  67. Gordo S, Pinheiro D, Moreira E, Rodrigues S, Poltronieri M, de Lemos O, et al. High-throughput sequencing of black pepper root transcriptome. BMC Plant Biol. 2012;12:168 pubmed publisher
    Black pepper (Piper nigrum L.) is one of the most popular spices in the world. It is used in cooking and the preservation of food and even has medicinal properties...
  68. El Hamss R, Idaomar M, Alonso Moraga A, Muñoz Serrano A. Antimutagenic properties of bell and black peppers. Food Chem Toxicol. 2003;41:41-7 pubmed
    ..melanogaster was used to study the modulating action of bell pepper (Capsicum annuum) and black pepper (Piper nigrum) in combination with the alkylating agent methyl methanesulfonate (MMS) and the promutagen agent ethyl ..
  69. Wei K, Li W, Koike K, Pei Y, Chen Y, Nikaido T. Complete 1H and 13C NMR assignments of two phytosterols from roots of Piper nigrum. Magn Reson Chem. 2004;42:355-9 pubmed
    ..chemical shifts were made for stigmastane-3,6-dione and stigmast-4-ene-3,6-dione, isolated from the roots of Piper nigrum (Piperaceae)...
  70. Truong N, Liew E, Burgess L. Characterisation of Phytophthora capsici isolates from black pepper in Vietnam. Fungal Biol. 2010;114:160-70 pubmed
    Phytophthora foot rot of black pepper caused by Phytophthora capsici is a major disease of black pepper (Piper nigrum) throughout Vietnam. To understand the population structure of P. capsici, a large collection of P...
  71. Hai Y, Kong X, Li J, Lei G. [Determination of thiophanate-methyl residue in peppers by solid phase extraction-HPLC]. Se Pu. 2005;23:319 pubmed
  72. Wu B, Fan R, Hu L, Wu H, Hao C. Genetic diversity in the germplasm of black pepper determined by EST-SSR markers. Genet Mol Res. 2016;15: pubmed publisher
    ..This verified the origin of black pepper. The newly developed EST-SSRs are highly valuable resources for the conservation of black pepper germplasm diversity and for black pepper breeding. ..
  73. Ahmad N, Abbasi B, Fazal H. Effect of different in vitro culture extracts of black pepper (Piper nigrum L.) on toxic metabolites-producing strains. Toxicol Ind Health. 2016;32:500-6 pubmed publisher
    ..Regenerated tissues of P. nigrum are a good source of biologically active metabolites for antimicrobial activities, and callus culture presented itself as a good candidate for such activities. ..
  74. Grosso C, Jäger A, Staerk D. Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC-SPE-NMR for advanced bioactivity profiling of plant extracts. Phytochem Anal. 2013;24:141-7 pubmed publisher
    ..New analytical technologies that allow simultaneously chemical and biological screening of extracts are therefore urgently needed...
  75. Atal S, Agrawal R, Vyas S, Phadnis P, Rai N. Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice. Acta Pol Pharm. 2012;69:965-9 pubmed
    ..Piperine, the chief alkaloid present in Piper nigrum (black pepper), has a wide array of uses in alternative and complementary therapies...
  76. K P S, R S. Integrated plant nutrient system - with special emphasis on mineral nutriton and biofertilizers for Black pepper and cardamom - A review. Crit Rev Microbiol. 2016;42:439-53 pubmed publisher
    ..This review focuses on the integrated plant nutrition system incorporating biofertilizer with special emphasis on developing and formulating biofertilizer consortium. ..
  77. Seddigi Z, Kandhro G, Shah F, Danish E, Soylak M. Assessment of metal contents in spices and herbs from Saudi Arabia. Toxicol Ind Health. 2016;32:260-9 pubmed publisher
    ..Consumers of these spices/herbs would not be exposed to any risk associated with the daily intake of 10 g of spices per day as far as metals Fe, Zn, Cu, Cr, Mn, Ni, and Pb are concerned...
  78. Bae H, Jayaprakasha G, Crosby K, Jifon J, Patil B. Influence of extraction solvents on antioxidant activity and the content of bioactive compounds in non-pungent peppers. Plant Foods Hum Nutr. 2012;67:120-8 pubmed publisher
  79. Siddiqui B, Gulzar T, Mahmood A, Begum S, Khan B, Afshan F. New insecticidal amides from petroleum ether extract of dried Piper nigrum L. whole fruits. Chem Pharm Bull (Tokyo). 2004;52:1349-52 pubmed
    The petroleum ether extract of dried ground whole fruits of Piper nigrum L...
  80. Thavara U, Tawatsin A, Bhakdeenuan P, Wongsinkongman P, Boonruad T, Bansiddhi J, et al. Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand. Southeast Asian J Trop Med Public Health. 2007;38:663-73 pubmed
    ..Mansf., Citrus hystrix DC., Curcuma longa L., Litsea cubeba (Lour.) Pers., Piper nigrum L., Psidium guajava L...
  81. Kumar A, Munder A, Aravind R, Eapen S, Tummler B, Raaijmakers J. Friend or foe: genetic and functional characterization of plant endophytic Pseudomonas aeruginosa. Environ Microbiol. 2013;15:764-79 pubmed publisher
    ..aeruginosa strains. Safety issues related to the selection of plant endophytic bacteria for crop protection are discussed...
  82. Samuel M, Oliver S, Coetzee M, Brooke B. The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes. Parasit Vectors. 2016;9:238 pubmed publisher
    ..Therefore, there is an urgent need for new insecticidal compounds. Black pepper (dried fruit from the vine, Piper nigrum), used as a food additive and spice, and its principal alkaloid piperine, have previously been shown to have ..
  83. Sajid M, Ali S. Mediation of cholino-piperine like receptors by extracts of Piper nigrum induces melanin dispersion in Rana tigerina tadpole melanophores. J Recept Signal Transduct Res. 2011;31:286-90 pubmed publisher
    The present study was carried out to determine the effects of lyophilized dried fruit extracts of Piper nigrum and pure piperine on the tadpole melanophores of frog Rana tigerina which offer excellent in vitro opportunities for studying ..
  84. Hirata N, Tokunaga M, Naruto S, Iinuma M, Matsuda H. Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf. Biol Pharm Bull. 2007;30:2402-5 pubmed
    Previously we reported that Piper nigrum leaf extract showed a potent stimulation effect on melanogenesis and that (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2) were isolated as active constituents...