piper

Summary

Summary: A plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.

Top Publications

  1. Hussain K, Ismail Z, Sadikun A, Ibrahim P. Antioxidant, anti-TB activities, phenolic and amide contents of standardised extracts of Piper sarmentosum Roxb. Nat Prod Res. 2009;23:238-49 pubmed publisher
    Ethanol and aqueous extracts of the different parts of Piper sarmentosum were analysed by HPLC for marker compounds to standardise these extracts...
  2. Arambewela L, Arawwawala L, Ratnasooriya W. Antidiabetic activities of aqueous and ethanolic extracts of Piper betle leaves in rats. J Ethnopharmacol. 2005;102:239-45 pubmed
    Leaves of Piper betle (Piperaceae) possess several bioactivities and are used in traditional medicinal systems. However, its antidiabetic activity has not been scientifically investigated so far...
  3. Lee S, Kim Y, Kim K, Lee H, Choi J, Lee W, et al. Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008;18:4544-6 pubmed publisher
    Eight alkamides 1-8 were isolated by bioassay-guided isolation of EtOH extracts of the fruits of Piper longum and Piper nigum (Piperaceae)...
  4. Oyedeji O, Adeniyi B, Ajayi O, Konig W. Essential oil composition of Piper guineense and its antimicrobial activity. Another chemotype from Nigeria. Phytother Res. 2005;19:362-4 pubmed
    The analysis of the essential oil of Piper guineense from Nigeria presents a new chemotype of constituents different from earlier reports with the absence of the usual myristicin...
  5. Moura do Carmo D, Amaral A, Machado G, Leon L, Silva J. Chemical and biological analyses of the essential oils and main constituents of Piper species. Molecules. 2012;17:1819-29 pubmed publisher
    The essential oils obtained from leaves of Piper duckei and Piper demeraranum by hydrodistillation were analyzed by gas chromatography-mass spectrometry. The main constituents found in P. demeraranum oil were limonene (19...
  6. Koroishi A, Foss S, Cortez D, Ueda Nakamura T, Nakamura C, Dias Filho B. In vitro antifungal activity of extracts and neolignans from Piper regnellii against dermatophytes. J Ethnopharmacol. 2008;117:270-7 pubmed publisher
    The present study was designated to evaluate the in vitro antidermatophyte activity of extracts from leaves of Piper regnellii as well as of the bioactivity-directed isolation of neolignans...
  7. Sunila E, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol. 2004;90:339-46 pubmed
    Alcoholic extract of the fruits of the plant Piper longum and its component piperine was studied for their immunomodulatory and antitumor activity...
  8. Suhana M, Farihah H, Faizah O, Nazrun S, Norazlina M, Norliza M, et al. Piper sarmentosum prevents glucocorticoid-induced osteoporotic bone resorption by increasing 11?-hydroxysteroid dehydrogenase type 1 activity. Clin Ter. 2011;162:313-8 pubmed
    ..Therefore, inhibition of this enzyme may reduce bone resorption markers. Piper sarmentosum (Ps) is a potent inhibitor of 11?HSD1 in liver and adipose tissue...
  9. Vijayakumar R, Nalini N. Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats. J Basic Clin Physiol Pharmacol. 2006;17:71-86 pubmed

More Information

Publications77

  1. Scodro R, Pires C, Carrara V, Lemos C, Cardozo Filho L, Souza V, et al. Anti-tuberculosis neolignans from Piper regnellii. Phytomedicine. 2013;20:600-4 pubmed publisher
    ..eupomatenoid-5 (1), conocarpan (4) and eupomatenoid-3 (7) and their derivatives (2, 3, 5, 6, and 8) from Piper regnellii, as well as their cytotoxicities...
  2. Rukachaisirikul T, Siriwattanakit P, Sukcharoenphol K, Wongvein C, Ruttanaweang P, Wongwattanavuch P, et al. Chemical constituents and bioactivity of Piper sarmentosum. J Ethnopharmacol. 2004;93:173-6 pubmed
    ..methyl piperate (12) and a mixture of beta-sitosterol (13) and stigmasterol (14), were isolated from the fruits of Piper sarmentosum (Piperaceae)...
  3. Dyer L, Dodson C, Stireman J, Tobler M, Smilanich A, Fincher R, et al. Synergistic effects of three Piper amides on generalist and specialist herbivores. J Chem Ecol. 2003;29:2499-514 pubmed
    The tropical rainforest shrub Piper cenocladum, which is normally defended against herbivores by a mutualistic ant, contains three amides that have various defensive functions...
  4. Amran A, Zakaria Z, Othman F, Das S, Raj S, Nordin N. Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits. Lipids Health Dis. 2010;9:44 pubmed publisher
    b>Piper sarmentosum (P.s) has flavonoid component in its leaves which has antioxidative effect. To date, its effect on atherosclerosis has not been studied histologically. The study aimed to investigate the effect of P...
  5. Bezerra D, Pessoa C, Moraes M, Alencar N, Mesquita R, Lima M, et al. In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. J Appl Toxicol. 2008;28:599-607 pubmed
    ..Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum...
  6. Tabopda T, Ngoupayo J, Liu J, Mitaine Offer A, Tanoli S, Khan S, et al. Bioactive aristolactams from Piper umbellatum. Phytochemistry. 2008;69:1726-31 pubmed publisher
    Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-..
  7. Taweechaisupapong S, Singhara S, Lertsatitthanakorn P, Khunkitti W. Antimicrobial effects of Boesenbergia pandurata and Piper sarmentosum leaf extracts on planktonic cells and biofilm of oral pathogens. Pak J Pharm Sci. 2010;23:224-31 pubmed
    ..this study aimed at determining the effects of oil and 95% ethanol extracts of Boesenbergia pandurata rhizomes and Piper sarmentosum leaf against four oral pathogens which were Streptococcus mutans, Lactobacillus sp...
  8. Verma V, Lobkovsky E, Gange A, Singh S, Prakash S. Piperine production by endophytic fungus Periconia sp. isolated from Piper longum L. J Antibiot (Tokyo). 2011;64:427-31 pubmed publisher
    ..This is the first report of the alternative source for this chemical other than its host, Piper longum...
  9. Ohno O, Watabe T, Nakamura K, Kawagoshi M, Uotsu N, Chiba T, et al. Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells. Biosci Biotechnol Biochem. 2010;74:1504-6 pubmed
    An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells...
  10. Ramos C, Vanin S, Kato M. Metabolism of (-)-grandisin from Piper solmsianum in Coleoptera and Lepidoptera species. Phytochemistry. 2008;69:2157-61 pubmed publisher
    The biotransformation of the major Piper solmsianum leaf phenylpropanoids, such as the tetrahydrofuran lignan grandisin and derivatives was investigated in the beetle Naupactus bipes as well as in the caterpillars Heraclides hectorides ..
  11. Paranjpe R, Gundala S, Lakshminarayana N, Sagwal A, Asif G, Pandey A, et al. Piper betel leaf extract: anticancer benefits and bio-guided fractionation to identify active principles for prostate cancer management. Carcinogenesis. 2013;34:1558-66 pubmed publisher
    ..Explored for their unique medicinal properties, the leaves of Piper betel, an evergreen perennial vine, are a reservoir of phenolics with antimutagenic, antitumor and antioxidant ..
  12. Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar G, Ghosh B. Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation. Eur J Pharmacol. 2007;575:177-86 pubmed
    ..It is the first amide to be isolated from Piper species...
  13. Lala L, D Mello P, Naik S. Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium. J Ethnopharmacol. 2004;91:277-80 pubmed
    quot;Trikatu"-an Ayurvedic formulation comprising of a 1:1:1 ratio of dried fruits of Piper nigrum, Piper longum and dried rhizomes of Zingiber officinale is widely used to enhance the bioavailability of drugs, like vasicine, ..
  14. Pullela S, Tiwari A, Vanka U, Vummenthula A, Tatipaka H, Dasari K, et al. HPLC assisted chemobiological standardization of alpha-glucosidase-I enzyme inhibitory constituents from Piper longum Linn-An Indian medicinal plant. J Ethnopharmacol. 2006;108:445-9 pubmed
    ..However, effective quality control methods in order to select right quality materials are lacking. Though Piper longum is a widely used herb in several Ayurvedic formulations prescribed for various diseases, there is no ..
  15. Connahs H, Rodríguez Castañeda G, Walters T, Walla T, Dyer L. Geographic variation in host-specificity and parasitoid pressure of an herbivore (geometridae) associated with the tropical genus piper (piperaceae). J Insect Sci. 2009;9:28 pubmed publisher
    ..The goals of this research were to examine: 1) whether Eois are specialized on the genus Piper (Piperaceae) and if hostplant specialization varies geographically; 2) whether Eois are equally vulnerable to ..
  16. Min K, Kim K, Ro J, Lee S, Kim J, Son J, et al. Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells. Planta Med. 2004;70:1115-8 pubmed
    ..In our ongoing study to find melanogenesis inhibitors from natural sources, Piper longum L (fruits, Piperaceae) was discovered to have an inhibitory effect on alpha-melanocyte-stimulating hormone (..
  17. de B F Ferraz A, Balbino J, Zini C, Ribeiro V, Bordignon S, von Poser G. Acaricidal activity and chemical composition of the essential oil from three Piper species. Parasitol Res. 2010;107:243-8 pubmed publisher
    The chemical composition of the essential oil obtained by hydrodistillation of the aerial parts of Piper amalago, Piper mikanianum, and Piper xylosteoides was elucidated by gas chromatography (GC) and GC/mass spectrometry analyses. P...
  18. Martins R, Lago J, Albuquerque S, Kato M. Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum. Phytochemistry. 2003;64:667-70 pubmed
    ..3,4,5-trimethoxybenzoic acid, isoelemicin and grandisin, two new tetrahydrofuran lignans were isolated from Piper solmsianun and characterized as rel-(7R,8R,7'R,8'R)-3',4'-methylenedioxy-3,4,5,5'-tetramethoxy-7,7'-epoxylignan ..
  19. Mikich S, Bianconi G, Maia B, Teixeira S. Attraction of the fruit-eating bat Carollia perspicillata to Piper gaudichaudianum essential oil. J Chem Ecol. 2003;29:2379-83 pubmed
    We performed field tests using mimetic Piper fruits with and without essential oil extracted through hydrodistillation from Piper gaudichaudianum ripe fruits in order to evaluate the role of odor in Carollia perspicillata attraction and ..
  20. Park B, Son D, Park Y, Kim T, Lee S. Antiplatelet effects of acidamides isolated from the fruits of Piper longum L. Phytomedicine. 2007;14:853-5 pubmed
    ..of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined...
  21. Lin L, Shen C, Shen Y, Tsai T. Anti-inflammatory neolignans from Piper kadsura. J Nat Prod. 2006;69:842-4 pubmed
    ..known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of Piper kadsura. The anti-inflammatory activities of these compounds were evaluated...
  22. Chen Y, Liao C, Chen I. Lignans, an amide and anti-platelet activities from Piper philippinum. Phytochemistry. 2007;68:2101-11 pubmed
    Investigation of the stem extract of Piper philippinum led to isolation of eight compounds, piperphilippinins I-VI (1-6), philippinamide (7), and (+)-bornyl caffeate (8), together with 26 known compounds...
  23. Barh D, Gupta K, Jain N, Khatri G, Leon Sicairos N, Canizalez Roman A, et al. Conserved host-pathogen PPIs. Globally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Pi. Integr Biol (Camb). 2013;5:495-509 pubmed publisher
    ..Ceftiofur, penicillin, and two natural compounds derived from Piper betel were predicted to inhibit Ack activity. One of these Piper betel compounds found to inhibit E...
  24. Marques J, Kitamura R, Lago J, Young M, Guimarães E, Kato M. Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. J Nat Prod. 2007;70:2036-9 pubmed
    Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A ( 1) and scutifoliamide B ( 2), together with the known compounds piperolactam C ( 3), ..
  25. Cícero Bezerra Felipe F, Trajano Sousa Filho J, de Oliveira Souza L, Alexandre Silveira J, Esdras de Andrade Uchoa D, Rocha Silveira E, et al. Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice. Phytomedicine. 2007;14:605-12 pubmed
    In the present work, we studied the effects of piplartine (PIP), an amide alkaloid isolated from the roots of Piper tuberculatum (Piperaceae), in the elevated plus maze, open field, rota rod, pentylenetetrazole (PTZ)-induced seizures, ..
  26. Pan L, Matthew S, Lantvit D, Zhang X, Ninh T, Chai H, et al. Bioassay-guided isolation of constituents of Piper sarmentosum using a mitochondrial transmembrane potential assay. J Nat Prod. 2011;74:2193-9 pubmed publisher
    Bioassay-guided fractionation was conducted on a chloroform-soluble extract of the aerial parts of Piper sarmentosum collected in Vietnam, monitored by a mitochondrial transmembrane potential assay using HT-29 human colon cancer cells...
  27. Ruddock P, Charland M, Ramirez S, Lopez A, Neil Towers G, Arnason J, et al. Antimicrobial activity of flavonoids from Piper lanceaefolium and other Colombian medicinal plants against antibiotic susceptible and resistant strains of Neisseria gonorrhoeae. Sex Transm Dis. 2011;38:82-8 pubmed publisher
    ..In the current study, 21 crude methanol extracts, from 19 plants used in Colombian traditional medicine for cutaneous infections, were screened for antimicrobial activity against NG...
  28. Kumar S, Kamboj J, Suman -, Sharma S. Overview for various aspects of the health benefits of Piper longum linn. fruit. J Acupunct Meridian Stud. 2011;4:134-40 pubmed publisher
    ..Thousands of plants have been used traditionally to treat various diseases. Among them, species of the genus Piper are important medicinal plants used in various systems of medicine...
  29. Lopes A, López S, Regasini L, Junior J, Ambrósio D, Kato M, et al. In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. Nat Prod Res. 2008;22:1040-6 pubmed publisher
    This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated...
  30. Ugusman A, Zakaria Z, Hui C, Nordin N. Piper sarmentosum increases nitric oxide production in oxidative stress: a study on human umbilical vein endothelial cells. Clinics (Sao Paulo). 2010;65:709-14 pubmed publisher
    ..b>Piper sarmentosum is a tropical plant with antioxidant and anti-inflammatory activities...
  31. Monzote L, García M, Montalvo A, Scull R, Miranda M. Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum. Mem Inst Oswaldo Cruz. 2010;105:168-73 pubmed
    ..In this paper, we characterised the essential oil from Piper auritum, evaluated its cytotoxicity and determined its antileishmanial activity...
  32. Ugusman A, Zakaria Z, Hui C, Nordin N. Piper sarmentosum inhibits ICAM-1 and Nox4 gene expression in oxidative stress-induced human umbilical vein endothelial cells. BMC Complement Altern Med. 2011;11:31 pubmed publisher
    Aqueous extract of Piper sarmentosum (AEPS) is known to possess antioxidant and anti-atherosclerotic activities but the mechanism responsible for it remains unclear...
  33. Fincher R, Dyer L, Dodson C, Richards J, Tobler M, Searcy J, et al. Inter- and intraspecific comparisons of antiherbivore defenses in three species of rainforest understory shrubs. J Chem Ecol. 2008;34:558-74 pubmed publisher
    ..We examined trade-offs among defenses in closely related tropical rain forest shrubs (Piper cenocladum, P. imperiale, and P...
  34. Huang H, Morgan C, Asolkar R, Koivunen M, Marrone P. Phytotoxicity of sarmentine isolated from long pepper (Piper longum) fruit. J Agric Food Chem. 2010;58:9994-10000 pubmed publisher
    ..In this article, we describe the finding that a methanol extract of dry long pepper (Piper longum L.) fruits is phytotoxic to lettuce (Lactuca sativa L.) seedlings...
  35. Torres M, White J, Bischoff J. Hypocrella panamensis sp. nov. (Clavicipitaceae, Hypocreales): a new species infecting scale insects on Piper carrilloanum in Panama. Mycol Res. 2007;111:317-23 pubmed
    ..In its biological habit Hypocrella panamensis is similar to other species in Hypocrella in that it infects and degrades the scale insect, then grows superficially on nutrients that emerge to the plant surface through the stylet wound...
  36. Cai Z, Penaflor C, Kuehl J, Leebens Mack J, Carlson J, dePamphilis C, et al. Complete plastid genome sequences of Drimys, Liriodendron, and Piper: implications for the phylogenetic relationships of magnoliids. BMC Evol Biol. 2006;6:77 pubmed
    ..We sequenced the plastid genomes of three magnoliids, Drimys (Canellales), Liriodendron (Magnoliales), and Piper (Piperales), and used these data in combination with 32 other angiosperm plastid genomes to assess phylogenetic ..
  37. Chen Y, Chen J, Chang Y, Teng C, Lin W, Wu C, et al. A new aristolactam alkaloid and anti-platelet aggregation constituents from Piper taiwanense. Planta Med. 2004;70:174-7 pubmed
    A new alkaloid, piperolactam E, and fourteen known compounds have been isolated from the stem of Piper taiwanense...
  38. Moraes J, Nascimento C, Lopes P, Nakano E, Yamaguchi L, Kato M, et al. Schistosoma mansoni: In vitro schistosomicidal activity of piplartine. Exp Parasitol. 2011;127:357-64 pubmed publisher
    ..Here, we report the in vitro effect of piplartine, an amide isolated from Piper tuberculatum (Piperaceae), on Schistosoma mansoni adult worms. A piplartine concentration of 15...
  39. Jirovetz L, Buchbauer G, Ngassoum M, Geissler M. Aroma compound analysis of Piper nigrum and Piper guineense essential oils from Cameroon using solid-phase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry. J Chromatogr A. 2002;976:265-75 pubmed
    The investigation of aroma compounds of the essential oils of dried fruits of black pepper (Piper nigrum) and black and white "Ashanti pepper" (Piper guineense) from Cameroon by means of solid-phase microextraction (SPME) was ..
  40. Jacob S, Finub J, Narayanan A. Synthesis of silver nanoparticles using Piper longum leaf extracts and its cytotoxic activity against Hep-2 cell line. Colloids Surf B Biointerfaces. 2012;91:212-4 pubmed publisher
    ..eco-friendly technique for green synthesis of silver nanoparticles from 1 mM AgNO(3) solution using the extract of Piper longum leaf as reducing as well as capping agent...
  41. Lee W, Kim K, Yu S, Kim S, Chun S, Ji J, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013;430:406-12 pubmed publisher
    ..This is the first report of pipernonaline toward the anticancer activity of prostate cancer cells, which provides a role for candidate agent as well as the molecular basis for human prostate cancer...
  42. Quilez A, Berenguer B, Gilardoni G, Souccar C, de Mendonça S, Oliveira L, et al. Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav. J Ethnopharmacol. 2010;128:583-9 pubmed publisher
    The leaves of Piper carpunya Ruiz & Pav. (syn Piper lenticellosum C.D.C...
  43. Yamaguchi L, Lago J, Tanizaki T, Mascio P, Kato M. Antioxidant activity of prenylated hydroquinone and benzoic acid derivatives from Piper crassinervium Kunth. Phytochemistry. 2006;67:1838-43 pubmed
    ..The prenylated hydroquinones had higher antioxidant activity than the benzoic acids and, among the hydroquinones, the E isomer was more efficient than the Z isomer...
  44. Rodrigues Silva D, Baroni S, Svidzinski A, Bersani Amado C, Cortez D. Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae). J Ethnopharmacol. 2008;116:569-73 pubmed publisher
    Leaves of Piper ovatum are known in folk medicine as "joão burandi" or "anestésica" and in traditional Brazilian medicine are used to treat inflammatory disease...
  45. Portet B, Fabre N, Roumy V, Gornitzka H, Bourdy G, Chevalley S, et al. Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense. Phytochemistry. 2007;68:1312-20 pubmed
    The bioassay-guided purification of an n-hexane extract from the leaves of Piper hostmannianum var...
  46. Navickiene H, Miranda J, Bortoli S, Kato M, Bolzani V, Furlan M. Toxicity of extracts and isobutyl amides from Piper tuberculatum: potent compounds with potential for the control of the velvetbean caterpillar, Anticarsia gemmatalis. Pest Manag Sci. 2007;63:399-403 pubmed
    ..amides pellitorine (compound 1) and 4,5-dihydropiperlonguminine (compound 2) were extracted from the seeds of Piper tuberculatum Jacq. (Piperaceae) in yields of 6.10 and 4.45% respectively...
  47. Kuete V, Sandjo L, Wiench B, Efferth T. Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinops giganteus, Xylopia aethiopica, Imperata cylindrica and Piper capense. J Ethnopharmacol. 2013;149:245-53 pubmed publisher
    Echinops giganteus, Imperata cylindrica, Piper capense and Xylopia aethiopica are four medicinal spices used in Cameroon to treat cancers.
  48. Lee M, Hsu J, Lin C, Lin M, Yuan S, Wang C. Induction of epidermal proliferation and expressions of PKC and NF-kappaB by betel quid extracts in mouse: the role of lime-piper additives in betel quid. Chem Biol Interact. 2002;140:35-48 pubmed
    ..In this study, the promoting effects of BQ and lime-piper additives (LPA) in BQ on epidermal hyperplasia in CD-1 mouse skin are investigated...
  49. Hermoso A, Jimenez I, Mamani Z, Bazzocchi I, Piñero J, Ravelo A, et al. Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity. Bioorg Med Chem. 2003;11:3975-80 pubmed
    Two dihydrochalcones (1 and 2) were isolated from Piper elongatum Vahl by activity-guided fractionation against extracellular promastigotes of Leishmania braziliensis in vitro...
  50. Sawangjaroen N, Sawangjaroen K, Poonpanang P. Effects of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall on caecal amoebiasis in mice. J Ethnopharmacol. 2004;91:357-60 pubmed
    The anti-amoebic effects of crude methanol extracts of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall against Entamoeba histolytica infecting the caecum of mice were studied...
  51. Scott I, Jensen H, Nicol R, Lesage L, Bradbury R, Sanchez Vindas P, et al. Efficacy of Piper (Piperaceae) extracts for control of common home and garden insect pests. J Econ Entomol. 2004;97:1390-403 pubmed
    Extracts from three species of the plant family Piperaceae, Piper nigrum [L.], Piper guineense [Schum & Thonn, and Piper tuberculatum [Jacq.], were tested for efficacy against insects from five orders...
  52. Tsai I, Lee F, Wu C, Duh C, Ishikawa T, Chen J, et al. New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Planta Med. 2005;71:535-42 pubmed
    ..E, and a new furanoid lignan, (+)-arborone, together with twelve known compounds, were isolated from the stems of Piper arborescens. The structures of these new compounds were determined by means of spectral analyses...
  53. Estai M, Suhaimi F, Das S, Fadzilah F, Alhabshi S, Shuid A, et al. Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study. Clinics (Sao Paulo). 2011;66:865-72 pubmed
    Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties.
  54. Silva M, Coímbra H, Pereira A, Almeida V, Lima T, Costa E, et al. Evaluation of piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens. Phytother Res. 2007;21:420-2 pubmed
    The activities of the crude ethanol extract from Piper cubeba seeds, (-)-cubebin and its semi-synthetic derivatives were evaluated against oral pathogens...
  55. Silva D, Endo E, Filho B, Nakamura C, Svidzinski T, de Souza A, et al. Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl. Molecules. 2009;14:1171-82 pubmed publisher
    ..Hydroalcoholic extracts of different parts of Piper ovatum Vahl, essential oil andamides isolated from leaves were tested against Gram-positive and Gram-negative ..
  56. Flores N, Jimenez I, Gimenez A, Ruiz G, Gutierrez D, Bourdy G, et al. Antiparasitic activity of prenylated benzoic acid derivatives from Piper species. Phytochemistry. 2009;70:621-7 pubmed publisher
    Fractionation of dichloromethane extracts from the leaves of Piper heterophyllum and P...
  57. Tuntiwachwuttikul P, Phansa P, Pootaeng on Y, Taylor W. Chemical constituents of the roots of Piper sarmentosum. Chem Pharm Bull (Tokyo). 2006;54:149-51 pubmed
    Sixteen compounds were isolated from the fresh roots of Piper sarmentosum...
  58. Flores N, Jimenez I, Gimenez A, Ruiz G, Gutierrez D, Bourdy G, et al. Benzoic acid derivatives from Piper species and their antiparasitic activity. J Nat Prod. 2008;71:1538-43 pubmed publisher
    b>Piper glabratum and P. acutifolium were analyzed for their content of main secondary constituents, affording nine new benzoic acid derivatives (1, 2, 4, 5, 7, and 10-13), in addition to four known compounds (3, 6, 8, and 9)...
  59. Christina A, Saraswathy G, Robert S, Kothai R, Chidambaranathan N, Nalini G, et al. Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?. Phytomedicine. 2006;13:196-8 pubmed
    This study was carried out to evaluate the antifibrotic effect of ethanol extract of the fruits of Indian herb Piper longum Linn. Liver fibrosis was induced in rats by CCl(4) administration...
  60. Lago J, Ramos C, Casanova D, Morandim A, Bergamo D, Cavalheiro A, et al. Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum. J Nat Prod. 2004;67:1783-8 pubmed
    b>Piper crassinervium, P. aduncum, P. hostmannianum, and P...
  61. Araújo M, Câmara C, Born F, Moraes M, Badji C. Acaricidal activity and repellency of essential oil from Piper aduncum and its components against Tetranychus urticae. Exp Appl Acarol. 2012;57:139-55 pubmed publisher
    The chemical composition of essential oil of leaves of Piper aduncum L., growing wild in a fragment of the Atlantic Rainforest biome in northeastern Brazil, was determined through gas chromatography-mass spectrometry...
  62. Lin M, Wang C, Huang H, Chou M, Chou F. The tumorigenic characteristics of lime-piper betel quid-transformed JB6 cells. Arch Toxicol. 2004;78:167-73 pubmed
    ..In this study, the tumor-promoting neoplastic transformation effect of Lime-Piper betel quid (LPB) was examined on JB6 cells. The treatment of LPB at a high dose (1...
  63. de Almeida R, Souto R, Bastos C, da Silva M, Maia J. Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil. Chem Biodivers. 2009;6:1427-34 pubmed publisher
    The essential oils of the specimens of Piper aduncum that occur in deforested areas of Brazilian Amazon, North Brazil, are rich in dillapiole (35-90%), a derivative of phenylpropene, to which are attributed biological properties...
  64. Vendrametto M, Santos A, Nakamura C, Dias Filho B, Cortez D, Ueda Nakamura T. Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens. Parasitol Int. 2010;59:154-8 pubmed publisher
    ..Here we investigated the antileishmanial activity of eupomatenoid-5, a neolignan isolated from leaves of Piper regnellii var. pallescens...
  65. Amran A, Zakaria Z, Othman F, Das S, Al Mekhlafi H, Nordin N. Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of piper sarmentosum on experimental rabbits fed with cholesterol diet. Lipids Health Dis. 2011;10:2 pubmed publisher
    ..The present study aimed to evaluate the effect of aqueous extract of Piper sarmentosum (P...
  66. Roersch C. Piper umbellatum L.: a comparative cross-cultural analysis of its medicinal uses and an ethnopharmacological evaluation. J Ethnopharmacol. 2010;131:522-37 pubmed publisher
    ..This review assesses the botany, traditional medicinal uses, phytochemistry, pharmacology and toxicology of P. umbellatum...
  67. Jin Z, Borjihan G, Zhao R, Sun Z, Hammond G, Uryu T. Antihyperlipidemic compounds from the fruit of Piper longum L. Phytother Res. 2009;23:1194-6 pubmed publisher
    A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents...
  68. Zakaria Z, Patahuddin H, Mohamad A, Israf D, Sulaiman M. In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. J Ethnopharmacol. 2010;128:42-8 pubmed publisher
    b>Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever.