corydalis

Summary

Summary: A plant genus of the family FUMARIACEAE (classified by some in PAPAVERACEAE) that contains isoquinoline alkaloids.

Top Publications

  1. Hu T, Zhang X, Ma S, Cheng Y, Yao X. [Chemical constituents from Corydalis yanhusuo]. Zhongguo Zhong Yao Za Zhi. 2009;34:1917-20 pubmed
    To study the chemical constituents from the 60% ethanol extract of Corydalis yanhusuo.
  2. Nawrot R, Wolun Cholewa M, Bialas W, Wyrzykowska D, Balcerkiewicz S, Gozdzicka Jozefiak A. Cytotoxic activity of proteins isolated from extracts of Corydalis cava tubers in human cervical carcinoma HeLa cells. BMC Complement Altern Med. 2010;10:78 pubmed publisher
    b>Corydalis cava Schweigg. & Koerte, the plant of numerous pharmacological activities, together with the studied earlier by our group Chelidonium majus L. (Greater Celandine), belong to the family Papaveraceae...
  3. Lei Y, Tan J, Wink M, Ma Y, Li N, Su G. An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1. Food Chem. 2013;136:1117-21 pubmed publisher
    ..A Chinese herbal plant Yanhusuo (Corydalis yanhusuo W.T...
  4. Hung T, Ngoc T, Youn U, Min B, Na M, Thuong P, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31:159-62 pubmed
    Pseudocoptisine, a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber, one of the important medicinal plants in traditional medicine...
  5. Qiu Y, Zong M, Yao Y, Chen B, Zhou X, Chen Z, et al. Genetic variation in wild and cultivated rhizoma corydalis revealed by ISSRs markers. Planta Med. 2009;75:94-8 pubmed publisher
    Rhizoma Corydalis is an important Chinese medicinal herb. In this paper, we employed ISSR data to explore the genetic variation in domesticated populations and wild populations of the species...
  6. Zhang J, Jin Y, Dong J, Xiao Y, Feng J, Xue X, et al. Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W.T. Wang using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Talanta. 2009;78:513-22 pubmed publisher
    ..This paper exploits this technique to identify the alkaloids in corydalis yanhusuo, an important antalgic Traditional Chinese Medicine (TCM)...
  7. Niu L, Xie Z, Cai T, Wu P, Xue P, Chen X, et al. Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution. J Sep Sci. 2011;34:987-94 pubmed publisher
    ..HSCCC) was successfully applied for the preparative separation and purification of alkaloids from Corydalis bungeana Turcz. (Kudiding in Chinese) for the first time...
  8. Cheong B, Choi D, Cho N, Lee J, Chang H, Shin M, et al. Modulation of Corydalis tuber on glycine-induced ion current in acutely dissociated rat periaqueductal gray neurons. Biol Pharm Bull. 2004;27:1207-11 pubmed
    Traditionally, Corydalis tuber has been used for the control of pain including headache, stomach ache, and neuralgia...
  9. Li W, Huang H, Zhang Y, Fan T, Liu X, Xing W, et al. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-?, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-?B activation and MAPK pathwa. Eur J Pharmacol. 2013;715:62-71 pubmed publisher
    The extracts or constituents from Corydalis impatiens are known to have many pharmacological activities...

More Information

Publications78

  1. Iwasa K, Kuribayashi A, Sugiura M, Moriyasu M, Lee D, Wiegrebe W. LC-NMR and LC-MS analysis of 2,3,10,11-oxygenated protoberberine metabolites in Corydalis cell cultures. Phytochemistry. 2003;64:1229-38 pubmed
    The metabolism of 2,3,10,11-oxygenated protoberberine alkaloids was studied in cell cultures of Corydalis species. Without prior isolation, the structures of the metabolites were determined by LC-MS and LC-NMR analyses...
  2. Lee T, Kim K, Lee S, Lee K, Son M, Jin M. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011;338:917-24 pubmed publisher
    ..isoquinoline alkaloid (5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine) from Corydalis tuber, and found that it has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5...
  3. Huang J, Fang M, Li Y, Ma Y, Cai X. [Analgesic effect of Corydalis yanhusuo in a rat model of trigeminal neuropathic pain]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:2161-4 pubmed
    To evaluate the analgesic effect of Corydalis yanhusuo on trigeminal neuropathic pain.in a rat model.
  4. Lee T, Son M, Kim S. Effects of corydaline from Corydalis tuber on gastric motor function in an animal model. Biol Pharm Bull. 2010;33:958-62 pubmed
    ..the prokinetic and gastric-relaxing effects of the isoquinoline alkaloid corydaline, which was extracted from Corydalis tubers (CT)...
  5. Xiao H, Peng J, Liang Y, Yang J, Bai X, Hao X, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011;25:1418-22 pubmed publisher
    ..6), coptisine (7) and dehydrocorydaline (8), were isolated from the methanolic extract of the tubers of Corydalis yanhusuo. Structures of these compounds were identified by spectroscopic techniques...
  6. Gao J, Shi J, Lee S, Zhang Q, Wang Y. Angiogenic pathway inhibition of Corydalis yanhusuo and berberine in human umbilical vein endothelial cells. Oncol Res. 2009;17:519-26 pubmed
    b>Corydalis yanhusuo, a well-known traditional Chinese medicine, is widely used in China as an analgesic for patients with terminal cancer. In this study, we want to expose the antiangiogenic effects and the underlying mechanisms of C...
  7. Yun K, Shin J, Choi J, Back N, Chung H, Lee K. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE(2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. Int Immunopharmacol. 2009;9:1323-31 pubmed publisher
    ..pseudocoptisine, a quaternary alkaloid with a benzylisoquinoline skeleton, which was isolated from the tubers of Corydalis turtschaninovii by examining its inhibitory effects on pro-inflammatory mediators in lipopolysaccharide (LPS)-..
  8. An H, Rim H, Chung H, Choi I, Kim N, Kim S, et al. Expression of inducible nitric oxide synthase by Corydalis turtschaninovii on interferon-gamma stimulated macrophages. J Ethnopharmacol. 2009;122:573-8 pubmed publisher
    b>Corydalis turtschaninovii (CT) has been used for tumor therapy. However, it is still unclear how this herb prevents the diseases in experimental models...
  9. Zhang Y, Yu Q, Zhao J, Guo Y. Differential effects of nectar robbing by the same bumble-bee species on three sympatric Corydalis species with varied mating systems. Ann Bot. 2009;104:33-9 pubmed publisher
    ..A system of three sympatric Corydalis species sharing the same nectar-robbing bumble-bee was therefore studied over 3 years in order to investigate ..
  10. Ling H, Wu L, Li L. Corydalis yanhusuo rhizoma extract reduces infarct size and improves heart function during myocardial ischemia/reperfusion by inhibiting apoptosis in rats. Phytother Res. 2006;20:448-53 pubmed
    The aim of the present investigation was to evaluate the effect of an extract from Corydalis yanhusuo W.T., a Chinese herbal medicine, on ischemia/reperfusion (I/R) injury and to determine the mechanism(s) involved...
  11. Xie C, Veitch N, Houghton P, Simmonds M. Flavonoid glycosides and isoquinolinone alkaloids from Corydalis bungeana. Phytochemistry. 2004;65:3041-7 pubmed
    ..7-O-beta-glucopyranosides of kaempferol and quercetin were isolated from the whole plant of Corydalis bungeana Turcz. together with eight known flavonol O-glycosides...
  12. Yuan C, Mehendale S, Wang C, Aung H, Jiang T, Guan X, et al. Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial. J Clin Pharmacol. 2004;44:1323-7 pubmed
    ..In this controlled clinical trial, the authors evaluated the analgesic effects of 2 herbal medicines, Corydalis yanhusuo and Angelicae dahuricae...
  13. Ding B, Zhou T, Fan G, Hong Z, Wu Y. Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD. J Pharm Biomed Anal. 2007;45:219-26 pubmed
    ..HPLC) with MS and UV-detection was developed for the qualitative and quantitative determination of alkaloids in Corydalis yanhusuo...
  14. Zhang J, Jin Y, Liu Y, Xiao Y, Feng J, Xue X, et al. Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC. J Sep Sci. 2009;32:1401-6 pubmed publisher
    ..liquid chromatography was successfully applied for the first time to isolate and purify alkaloids from Corydalis yanhusuo...
  15. Xu Z, Chen X, Zhang Q, Chen L, Wang Y. Corydalis yanhusuo W.T. Wang extract inhibits MCF-7 cell proliferation by inducing cell cycle G2/M arrest. Am J Chin Med. 2011;39:579-86 pubmed
    b>Corydalis yanhusuo W.T. Wang (YHS) is a traditional Chinese herb widely prescribed for promoting blood circulation, reinforcing vital energy and alleviating pain...
  16. Saito S, Tanaka M, Matsunaga K, Li Y, Ohizumi Y. The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber. Biol Pharm Bull. 2004;27:1270-4 pubmed
    ..We have applied this bioassay to search anti-allergic ingredient from a total methanolic extract of Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. HSU)...
  17. Zhu X, Zhang Z, Li P, Liang W, Feng X, Liu M. Shenyuan, an extract of American Ginseng and Corydalis Tuber formula, attenuates cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and oxidative stress in a porcine model of acute myocardial infarction. J Ethnopharmacol. 2013;150:672-81 pubmed publisher
    The decoction of American Ginseng and Corydalis Tuber has been widely used for treatment of cardiovascular diseases due to their anti-ischemic and anti-arrhythmic effects...
  18. Hung T, Na M, Dat N, Ngoc T, Youn U, Kim H, et al. Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii. J Ethnopharmacol. 2008;119:74-80 pubmed publisher
    ..course of screening plants used in Korean folk medicine as memory enhancers, a 70% ethanol extract of tuber from Corydalis turtschaninovii Besser (Papaveraceae) showed significant acetylcholinesterase (AChE) inhibitory activity...
  19. Li H, Han T, Liu R, Zhang C, Chen H, Zhang W. Alkaloids from Corydalis saxicola and their anti-hepatitis B virus activity. Chem Biodivers. 2008;5:777-83 pubmed publisher
    Eight protoberberine-type alkaloids and two indole alkaloids were isolated from the MeOH extracts of the herb Corydalis saxicola Bunting (Papaveraceae)...
  20. Lee T, Choi J, Kim D, Choi S, Lee K, Son M, et al. Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber. Phytomedicine. 2008;15:836-43 pubmed publisher
    ..for functional dyspepsia (FD), a prokinetic agent, DA-9701 has been newly formulated with Pharbitis Semen and Corydalis Tuber and we evaluated the gastroprokinetic effects of DA-9701 in comparison with conventional prokinetics...
  21. Henkes H, Franz M, Kendall O, Monroe J, Legaspi A, LeDoux J, et al. Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat. AANA J. 2011;79:S75-80 pubmed
    ..Tetrahydropalmatine (THP), an active component isolated from the Chinese herbal plant Corydalis yanhusuo, is used in Asia for its analgesic, sedative, and hypnotic properties during herbal therapy...
  22. Wu Y, Ma Y, Zhao Y, Yao S, Zhou J, Zhou Y, et al. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola. Planta Med. 2007;73:787-91 pubmed
    ..A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3 - 18) were isolated from Corydalis saxicola Bunting...
  23. Kim D, Lee K, Baek N, Kim S, Park H, Lim J, et al. Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. Arch Pharm Res. 2004;27:1127-31 pubmed
    ..2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques...
  24. Halbsguth C, Meissner O, Häberlein H. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site. Planta Med. 2003;69:305-9 pubmed
    Protoberberine alkaloids from the rhizomes of Corydalis cava were investigated with regard to their influence on the GABA A receptor using radioreceptor assays...
  25. Shi J, Zhang X, Ma Z, Zhang M, Sun F. Characterization of aromatase binding agents from the dichloromethane extract of Corydalis yanhusuo using ultrafiltration and liquid chromatography tandem mass spectrometry. Molecules. 2010;15:3556-66 pubmed publisher
    ..In the present study, nine alkaloids from the dichloromethane extract of Corydalis yanhusuo were identified by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tested for their ..
  26. Kim K, Piao C, Choi S, Son M, Lee K. New cytotoxic tetrahydroprotoberberine-aporphine dimeric and aporphine alkaloids from Corydalis turtschaninovii. Planta Med. 2010;76:1732-8 pubmed publisher
    ..with 13 known protoberberine (4-16) and nine known aporphine alkaloids (17-25), were isolated from the tubers of Corydalis turtschaninovii...
  27. Liao Z, Liang X, Zhu J, Zhao G, Yang M, Wang G, et al. Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP. J Ethnopharmacol. 2010;129:115-20 pubmed publisher
    Yuanhu Zhitong prescription that consists of Corydalis yanhusuo and Radix Angelicae dahuricae has been used for the treatment of gastralgia, costalgia, headache and dysmenorrhea in Traditional Chinese Medicine...
  28. Adsersen A, Kjølbye A, Dall O, Jäger A. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort. J Ethnopharmacol. 2007;113:179-82 pubmed
    ..of screening plants used in Danish folk medicine as memory enhancers, a crude methanolic extract of tubers from Corydalis cava showed significant acetylcholinesterase inhibitory activity in a dose-dependent manner...
  29. Gao J, Shi J, He K, Zhang Q, Li S, Lee S, et al. Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncol Rep. 2008;20:819-24 pubmed
    Yanhusuo (Corydalis yanhusuo W.T. Wang) is a well-known traditional Chinese medicine (TCM)...
  30. Li H, Zhang W, Liu R, Zhang C, Han T, Wang X, et al. Simultaneous determination of four active alkaloids from a traditional Chinese medicine Corydalis saxicola Bunting. (Yanhuanglian) in plasma and urine samples by LC-MS-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;831:140-6 pubmed
    ..thereafter called YHL-I, YHL-II, YHL-III, and YHL-IV, respectively) from a Chinese traditional medicine Corydalis saxicola Bunting. (Yanhuanglian) in rat plasma and urine was established and validated...
  31. Wu L, Ling H, Li L, Jiang L, He M. Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction. J Pharm Pharmacol. 2007;59:695-701 pubmed
    As indicated in ancient Chinese medical books, Corydalis yanhusuo has therapeutic effects on cardiovascular diseases...
  32. Gao J, He T, Li Y, Wang Y. A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity. Oncol Rep. 2009;22:1077-83 pubmed
    ..Yanhusuo San' (YHSS), which consists of yanhusuo (Rhizoma Corydalis) and Ezhu (Rhizoma Curcumae), has been an archaic Chinese medicine prescription since the Song dynasty (960-1279 ..
  33. Cheng X, Shi Y, Sun H, Jin W, Zheng S, Li K, et al. [Identification and analysis of absorbed components in rat plasma after oral administration of active fraction of Corydalis yanhusuo by LC-MS/MS]. Yao Xue Xue Bao. 2009;44:167-74 pubmed
    To analyze and identify the constituents in rat plasma after oral administration of the active fraction of Corydalis yanhusuo, a LC-MS/MS method was established...
  34. Liu L, Yu X, Wang Z, Sun J, Pan R, Yang C, et al. Simultaneous determination and pharmacokinetics of five alkaloids in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry after the oral administration of Corydalis bungeana Turcz extract. J Sep Sci. 2016;39:296-305 pubmed publisher
    ..acetylcorynoline, and 8-oxocorynoline, five main active components from Corydalis bungeana Turcz (C. bungeana Turcz)...
  35. Novak Z, Chlebek J, Opletal L, Jiros P, Macakova K, Kunes J, et al. Corylucinine, a new alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity. Nat Prod Commun. 2012;7:859-60 pubmed
    A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained...
  36. Wu H, Wang P, Liu M, Tang L, Fang J, Zhao Y, et al. A 1H-NMR-Based Metabonomic Study on the Anti-Depressive Effect of the Total Alkaloid of Corydalis Rhizoma. Molecules. 2015;20:10047-64 pubmed publisher
    b>Corydalis Rhizoma, named YuanHu in China, is the dried tuber of Corydalis yanhusuo W.T. Wang which is used in Traditional Chinese Medicine for pain relief and blood activation...
  37. Gao D, Wang B, Huo Z, He Y, Polachi N, Lei Z, et al. Analysis of chemical constituents in an herbal formula Jitong Ning Tablet. J Pharm Biomed Anal. 2017;140:301-312 pubmed publisher
    ..Chinese herbal formula, consists of Eucommia ulmodies oliv, Angelicae pubescentis radix, Aconiti radix cocta, Corydalis yanhusuo w.t. wang, Glycyrrhizae radix et rhizoma, Paeoniae radix rubra and Radix puerariae...
  38. Chen X, Zhang Y, Lin S, Yang H, Wu H, Li S, et al. [Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method]. Zhongguo Zhong Yao Za Zhi. 2012;37:2005-11 pubmed
    ..As ingredients are selectively absorbed in intestinal sac, the everted intestinal sac method is selected to assess the intestinal absorption characteristics of ingredients of Yuanhuzhitong prescription. ..
  39. Lobbens E, Vissing K, Jorgensen L, van de Weert M, Jäger A. Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity. J Ethnopharmacol. 2017;200:66-73 pubmed publisher
    ..Furthermore, five plant extracts from Corydalis species inhibited the enzymatic activity of acetylcholinesterase considerably, one plant extract inhibited the ..
  40. Vandelook F, van Assche J. Temperature conditions control embryo growth and seed germination of Corydalis solida (L.) Clairv., a temperate forest spring geophyte. Plant Biol (Stuttg). 2009;11:899-906 pubmed publisher
    ..the requirements for breaking dormancy and for seed germination of the European perennial spring geophyte Corydalis solida (Fumariaceae). Ripe seeds of C...
  41. Yoo M, Lee S, Kim Y, Seo D, Baek N, Ryu J, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016;14:3029-36 pubmed publisher
    ..In a screen of natural compounds for the enhancement of MyoD activity, dehydrocorydaline (DHC) from the Corydalis tuber was identified...
  42. Shen Y, Han C, Xia B, Zhou Y, Liu C, Liu A. [Determination of four alkaloids in Corydalis decumbens by HPLC]. Zhongguo Zhong Yao Za Zhi. 2011;36:2110-2 pubmed
    ..HPLC method for determination of protopine, palmatine hydrochloride, bicuculline and tetrahydropalmatine, in Corydalis decumbens. The separation was performed on a ZORBAX Eclipse XDB-C18 column (4...
  43. Hu X, Sun A, Yu L, Wu Q. [Effects of Corydalis ambailis migo total alkaloids on experimental cerebral ischemia]. Zhong Xi Yi Jie He Xue Bao. 2005;3:46-9 pubmed
    To observe the protective effects of Corydalis ambailis migo total alkaloids (COAMTA) on cerebral ischemia/reperfusion injury in rats and to investigate its mechanism...
  44. Cheng X, Shi Y, Zhen S, Sun H, Jin W. HPLC-MS analysis of ethanol extract of Corydalis yanhusuo and simultaneous determination of eight protoberberine quaternary alkaloids by HPLC-DAD. J Chromatogr Sci. 2010;48:441-4 pubmed
    ..liquid chromatography (HPLC)-electrospray tandem mass spectrometry (ESI-MS-MS) for the ethanol extract of Corydalis yanhusuo was established in this study...
  45. Ma Z, Xu W, Jensen N, Roth B, Liu Chen L, Lee D. Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules. 2008;13:2303-12 pubmed
    Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and ..
  46. Liu J, Han X. [Study on time-effect and dose-effect of serum containing Chinese herbal medicine]. Zhongguo Zhong Yao Za Zhi. 2006;31:829-31 pubmed
    ..The suppression rate of LDH release was also different in drug serum taken at different time after SSTG treatment. It was not the case that the higher the dose given to animal, the better the pharmacological effects. ..
  47. Zhou Q, Deng A, Qin H. Two new quaternary protoberberine alkaloids from Corydalis yanhusuo. J Asian Nat Prod Res. 2012;14:476-81 pubmed publisher
    ..protoberberine alkaloids, namely corydayanine (1) and yanhusuine (2), were isolated from the tubers of Corydalis yanhusuo...
  48. Singh N, Azmi S, Maurya S, Singh U, Jha R, Pandey V. Two plant alkaloids isolated from Corydalis longipes as potential antifungal agents. Folia Microbiol (Praha). 2003;48:605-9 pubmed
    The alkaloids N-methylhydrasteine hydroxylactam and 1-methoxyberberine chloride were isolated from Corydalis longipes...
  49. Wu F, Zheng H, Yang Z, Cheng B, Wu J, Liu X, et al. Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using 1H NMR analysis. J Pharm Biomed Anal. 2017;140:199-209 pubmed publisher
    ..The total alkaloids of Corydalis saxicola Bunting (TACS), a collection of important bioactive ingredients derived from the traditional Chinese ..
  50. Xu W, Wang Y, Ma Z, Chiu Y, Huang P, Rasakham K, et al. L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors. Drug Alcohol Depend. 2013;133:693-703 pubmed publisher
    ..of l-isocorypalmine (l-ICP), a mono-demethylated analog of l-tetrahydropalmatine (l-THP), from the plant Corydalis yanhusuo...
  51. Cheng X, Wang D, Jiang L, Yang D. Simultaneous determination of eight bioactive alkaloids in Corydalis saxicola by high-performance liquid chromatography coupled with diode array detection. Phytochem Anal. 2008;19:420-8 pubmed publisher
    b>Corydalis saxicola Bunting (Papaveraceae), a traditional folk medicine, has been used to treat hepatic diseases for a long time. Owing to its signicant clinical effectiveness against hepatitis, cirrhosis and hepatoma, C...
  52. Wang C, Guo Z, Zhang J, Zeng J, Zhang X, Liang X. High-performance purification of quaternary alkaloids from Corydalis yanhusuo W. T. Wang using a new polar-copolymerized stationary phase. J Sep Sci. 2011;34:53-8 pubmed publisher
    An efficient method for purification of alkaloids from Corydalis yanhusuo W. T. Wang using HPLC was developed, featuring a polar-copolymerized stationary phase named C18HCE...
  53. Jeong E, Lee S, Yu S, Park N, Lee H, Yim Y, et al. Identification of structurally diverse alkaloids in Corydalis species by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2012;26:1661-74 pubmed publisher
    Alkaloids with significant therapeutic effects are the main active constituents of Corydalis (C.) species. There are several kinds of alkaloids in C...
  54. Ou J, Kong L, Pan C, Su X, Lei X, Zou H. Determination of DL-tetrahydropalmatine in Corydalis yanhusuo by L-tetrahydropalmatine imprinted monolithic column coupling with reversed-phase high performance liquid chromatography. J Chromatogr A. 2006;1117:163-9 pubmed
    A method for direct determination of DL-tetrahydropalmatine (DL-THP) in Corydalis yanhusuo, a traditional Chinese herb, by L-THP imprinted monolithic precolumn on-line/off-line coupling with reversed-phase high performance liquid ..
  55. Kudo G, Ida T. Early onset of spring increases the phenological mismatch between plants and pollinators. Ecology. 2013;94:2311-20 pubmed
    ..We investigated the phenologies of a spring ephemeral, Corydalis ambigua, and its pollinators (bumble bees), and seed-set success over 10-14 years in three populations...
  56. Könczöl A, Muller J, Földes E, Béni Z, Végh K, Kery A, et al. Applicability of a blood-brain barrier specific artificial membrane permeability assay at the early stage of natural product-based CNS drug discovery. J Nat Prod. 2013;76:655-63 pubmed publisher
    ..was demonstrated using extracts prepared from Tanacetum parthenium, Vinca major, Salvia officinalis, and Corydalis cava, representing different types of chemical diversity and complexity...
  57. Mao Z, Wang X, Liu Y, Huang Y, Liu Y, Di X. Simultaneous determination of seven alkaloids from Rhizoma Corydalis Decumbentis in rabbit aqueous humor by LC-MS/MS: Application to ocular pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1057:46-53 pubmed publisher
    ..to establish a fast and sensitive LC-MS/MS method for simultaneous determination of seven alkaloids from Rhizoma Corydalis Decumbentis in rabbit aqueous humor...
  58. Bruce W, Fonder H, Compton J, Garrett N. Investigation of modulation of the alpha-2 receptor in tetrahydropalmatine (THP) analgesia in male Sprague-Dawley rats. J Diet Suppl. 2009;6:13-21 pubmed publisher
    ..2000). Tetrahydropalmatine (THP), a derivative of the herb corydalis, may have analgesic properties (Hu & Jin, 2000a; Wei, Zou, Young, Dubner, & Ren, 1999); however, the ..
  59. Ahn B, Kim J, Kong C, Seo Y, Kim S. Protective effect of (2'S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage. J Photochem Photobiol B. 2012;109:20-7 pubmed publisher
    A salt tolerant plant, Corydalis heterocarpa has been used as a folk medicine to treat travail and spasm. Recent studies have also reported antioxidant and antiinflammatory activities of compounds isolated from C. heterocarpa...
  60. Shen Y, Han C, Jiang Y, Zhou X, Zhu Z, Lei X. Rapid quantification of four major bioactive alkaloids in Corydalis decumbens (Thunb.) Pers. by pressurised liquid extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Talanta. 2011;84:1026-31 pubmed publisher
    ..analysis has been developed for the identification and quantification of four major alkaloids in extracts of Corydalis decumbens (Thunb.) Pers...
  61. Khodorova N, Miroslavov E, Shavarda A, Laberche J, Boitel Conti M. Bud development in corydalis (Corydalis bracteata) requires low temperature: a study of developmental and carbohydrate changes. Ann Bot. 2010;105:891-903 pubmed publisher
    ..The present study aims to compare the developmental anatomy and carbohydrate content of the tuberous geophyte Corydalis bracteata growing under natural winter conditions from 10 to -10 degrees C (field-grown) and under a mild ..
  62. Ren J, Xu J, Yu X. [Study on the influence on Rhizoma Corydalis by different harvest time and processing methods]. Zhong Yao Cai. 2009;32:1026-8 pubmed
    To choose the best harvest time and initial processing method of Rhizoma Corydalis.
  63. Jha R, Pandey M, Singh A, Singh S, Singh V. New alkaloids from Corydalis species. Nat Prod Res. 2009;23:250-5 pubmed publisher
    ..isocorypalmine, (-)-corydalmine and (+)-bicuculline have been isolated from the crude base fraction of Corydalis chaerophylla...
  64. Xu X, Yu G, Wang Z. [Resource investigation and quality evaluation on wild Corydalis yanhusuo]. Zhongguo Zhong Yao Za Zhi. 2004;29:399-401 pubmed
    To study the resource and the quality of wild Corydalis yanhusuo distributed in China.
  65. Xu J, Sun Y, Yu X, Ren J, Wang Z. [Study on method of Corydalis yanhusuo producing and concocting integration processing]. Zhongguo Zhong Yao Za Zhi. 2011;36:2484-8 pubmed
    To establish integration processing method for pretreating and vinegar producing Corydalis yanhusuo.
  66. Lu H, Wang S, Cai R, Meng Y, Xie X, Zhao W. Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy. J Pharm Biomed Anal. 2012;59:44-9 pubmed publisher
    ..of near-infrared spectroscopy (NIRS), a convenient and rapid method for determination of alkaloids in Corydalis Tuber extract and classification for samples from different locations have been developed...
  67. Guo Z, Wang C, Liang T, Liang X. Polar-copolymerized approach based on horizontal polymerization on silica surface for preparation of polar-modified stationary phases. J Chromatogr A. 2010;1217:4555-60 pubmed
    ..In addition, the application results demonstrated that the C18HCE had superior separation performance in alkaloids separation at acidic conditions compared to some commercial stationary phases...
  68. Zhao D, Tang Y, Wang H. [Studies on the alkaloids from herb of Corydalis adunca]. Zhongguo Zhong Yao Za Zhi. 2005;30:1756-7 pubmed
    To study the alkaloid constituents of Corydalis adunca.
  69. Goel M, Singh U, Jha R, Pandey V, Pandey M. Individual and combined effect of (+/-)-alpha-hydrastine and (+/-)-beta-hydrastine on spore germination of some fungi. Folia Microbiol (Praha). 2003;48:363-8 pubmed
    alpha-Hydrastine and (+/-)-beta-hydrastine were isolated from Corydalis longipes; both exhibited considerable efficacy against spore germination of some saprophytic and phytopathogenic fungi...