chelidonium

Summary

Summary: A plant genus in the family PAPAVERACEAE, order Papaverales, subclass Magnoliidae.

Top Publications

  1. Kim Y, Shin M, Chung J, Kim E, Koo G, Lee C, et al. Modulation of Chelidonii herba on GABA activated chloride current in rat PAG neurons. Am J Chin Med. 2001;29:265-79 pubmed
    ..These results suggest that the inhibitory modulation of Chelidonii herba on GABA activated current via G-proteins in PAG neuron is an important analgesic mechanism. ..
  2. Stickel F, Pöschl G, Seitz H, Waldherr R, Hahn E, Schuppan D. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand J Gastroenterol. 2003;38:565-8 pubmed
    We report on two cases of acute liver injury along with the intake of Greater Celandine (Chelidonium majus), a well-known herbal remedy frequently used for irritable bowel syndrome...
  3. Barreto M, Pinto R, Arrabaça J, Pavão M. Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids. Toxicol Lett. 2003;146:37-47 pubmed
    The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e...
  4. Chung H, An H, Jeong H, Won J, Hong S, Kim H. Water extract isolated from Chelidonium majus enhances nitric oxide and tumour necrosis factor-alpha production via nuclear factor-kappaB activation in mouse peritoneal macrophages. J Pharm Pharmacol. 2004;56:129-34 pubmed
    b>Chelidonium majus is used to treat several inflammatory diseases and tumours. We have examined the effect of C. majus on nitric oxide (NO) production using mouse peritoneal macrophages. When C...
  5. Ernst E, Schmidt K. Ukrain - a new cancer cure? A systematic review of randomised clinical trials. BMC Cancer. 2005;5:69 pubmed
    Ukrain is an anticancer drug based on the extract of the plant Chelidonium majus L. Numerous pre-clinical and clinical investigations seem to suggest that Ukrain is pharmacologically active and clinically effective...
  6. Nawrot R, Kalinowski A, Gozdzicka Jozefiak A. Proteomic analysis of Chelidonium majus milky sap using two-dimensional gel electrophoresis and tandem mass spectrometry. Phytochemistry. 2007;68:1612-22 pubmed
    Milky sap, a milky-like orange fluid, isolated from the Greater Celandine (Chelidonium majus L...
  7. Lee Y, Kim S, Roh S, Choi H, Seo Y. Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice. J Ethnopharmacol. 2007;112:40-8 pubmed
    b>Chelidonium majus L. has multiple applications in Korean traditional medicine because of its anti-tumoral, cytotoxic, anti-inflammatory and anti-microbial activities and has long been known to have anti-inflammatory effects...
  8. Ikeuchi M, Tatematsu K, Yamaguchi T, Okada K, Tsukaya H. Precocious progression of tissue maturation instructs basipetal initiation of leaflets in Chelidonium majus subsp. asiaticum (Papaveraceae). Am J Bot. 2013;100:1116-26 pubmed publisher
    ..In this study, we compared two species in the Papaveraceae with different directions of leaflet initiation, Chelidonium majus subsp. asiaticum (basipetal) and Eschscholzia californica (acropetal). Because E...
  9. Mazzanti G, Di Sotto A, Franchitto A, Mammola C, Mariani P, Mastrangelo S, et al. Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment. J Ethnopharmacol. 2009;126:518-24 pubmed publisher
    Aerial parts of Chelidonium majus L. (Papaveraceae family) are traditionally used in the treatment of gallstones and dyspepsia, however several cases of hepatotoxicity are reported...

More Information

Publications85

  1. Gilca M, Gaman L, Panait E, Stoian I, Atanasiu V. Chelidonium majus--an integrative review: traditional knowledge versus modern findings. Forsch Komplementmed. 2010;17:241-8 pubmed publisher
    b>Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C...
  2. Nawrot R, Wołuń Cholewa M, Gozdzicka Jozefiak A. Nucleases isolated from Chelidonium majus L. milky sap can induce apoptosis in human cervical carcinoma HeLa cells but not in Chinese Hamster Ovary CHO cells. Folia Histochem Cytobiol. 2008;46:79-83 pubmed publisher
    Milky sap isolated from Chelidonium majus L. (Greater Celandine) serves as a rich source of various biologically active substances such as alkaloids, flavonoids and phenolic acids. Previous research showed that the activity of Ch...
  3. Biswas S, Bhattacharjee N, Khuda Bukhsh A. Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice. Food Chem Toxicol. 2008;46:1474-87 pubmed publisher
    Ethanolic whole plant extract of Chelidonium majus, extensively used in traditional systems of medicine against various liver ailments, has been tested for its possible anti-tumor, hepato-protective and anti-genotoxic effects in p-..
  4. Zhou Q, Liu Y, Wang X, Di X. A sensitive and selective liquid chromatography-tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. in rat plasma and its application to a pharmacokinetic study. J Mass Spectrom. 2013;48:111-8 pubmed publisher
    b>Chelidonium majus L. is one of the most important medicinal plants of the family Papaveraceae. Its pharmacological effects have been primarily attributed to the presence of a number of alkaloids...
  5. Kuenzel J, Geisler K, Strahl O, Grundtner P, Beckmann M, Dittrich R. Chelidonium majus and its effects on uterine contractility in a perfusion model. Eur J Obstet Gynecol Reprod Biol. 2013;169:213-7 pubmed publisher
    ..The aim of the present study was to investigate the effect of celandine on the uterine muscle, using a perfusion model of swine uteri...
  6. Jang S, Kim B, Lee W, An S, Choi H, Jeon B, et al. Stylopine from Chelidonium majus inhibits LPS-induced inflammatory mediators in RAW 264.7 cells. Arch Pharm Res. 2004;27:923-9 pubmed
    Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries...
  7. Cordes N, Plasswilm L, Bamberg M, Rodemann H. Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation. Int J Radiat Biol. 2002;78:17-27 pubmed
    Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L., has demonstrated a promising impact on chemotherapy in a variety of malignancies...
  8. Fil chenkov O, Zavelevych M, Khranovs ka N, Zaïka L, Potopal s kyĭ A. [Modified alkaloids from Chelidonium majus L. induce G2/M arrest, caspase-3 activation, and apoptosis in human acute lymphoblastic leukemia MT-4 cells]. Ukr Biokhim Zh (1999). 2006;78:81-7 pubmed
    The novel anticancer drug amitosine representing the mixture of thiophosphamide-modified alkaloids from Chelidonium majus L. has been reported to inhibit growth of various solid tumors in vivo...
  9. Crijns A, De Smet P, van den Heuvel M, Schot B, Haagsma E. [Acute hepatitis after use of a herbal preparation with greater celandine (Chelidonium majus)]. Ned Tijdschr Geneeskd. 2002;146:124-8 pubmed
    ..due to acute hepatitis several weeks after ingestion of a herbal preparation containing greater celandine (Chelidonium majus) and curcuma root, which had been prescribed by an alternative therapist due to a skin complaint...
  10. Nawrot R, Lesniewicz K, Pienkowska J, Gozdzicka Jozefiak A. A novel extracellular peroxidase and nucleases from a milky sap of Chelidonium majus. Fitoterapia. 2007;78:496-501 pubmed
    ..SDS-PAGE, peroxidase activity assay and mass spectrometry data, a new extracellular peroxidase (CMP) from Chelidonium majus milky sap was isolated and characterized...
  11. Park J, Cuong T, Hung T, Lee I, Na M, Kim J, et al. Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells. Bioorg Med Chem Lett. 2011;21:6960-3 pubmed publisher
    ..norchelidonine (4), chelidonine (5), berberine (6), and 8-hydroxydihydrosanguinarine (7), were isolated from Chelidonium majus...
  12. Groot E, Sinha N, Gleissberg S. Expression patterns of STM-like KNOX and Histone H4 genes in shoot development of the dissected-leaved basal eudicot plants Chelidonium majus and Eschscholzia californica (Papaveraceae). Plant Mol Biol. 2005;58:317-31 pubmed
    ..Here we report the isolation of class I KNOX genes from two species of the basal eudicot family Papaveraceae, Chelidonium majus and Eschscholzia californica...
  13. Biswas S, Khuda Bukhsh A. Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium majus, during azo dye induced hepatocarcinogenesis in mice. Indian J Exp Biol. 2004;42:698-714 pubmed
    Several cytogenetical and enzymatic protocols were used to test if two microdoses of Chelidonium majus, namely Chelidonium-30 (Ch-30) and Chelidonium-200 (Ch-200), used as homeopathic drugs, showed anti-tumor activity and also favorably ..
  14. Biswas S, Pathak S, Bhattacharjee N, Das J, Khuda Bukhsh A. Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice. J Altern Complement Med. 2005;11:839-54 pubmed
    ..to examine whether the potentized homeopathic remedy Carcinosin 200, fed alone and in combination with Chelidonium 200, has differential protective effects against p-dimethylaminoazobenzene (p-DAB)-induced hepatocarcinogenesis ..
  15. Banerjee A, Pathak S, Biswas S, Roy Karmakar S, Boujedaini N, Belon P, et al. Chelidonium majus 30C and 200C in induced hepato-toxicity in rats. Homeopathy. 2010;99:167-76 pubmed publisher
    ..Homeopathy is a popular form of complementary and alternative medicine and is used to treat for certain liver ailments...
  16. Kuznetsova L, Nikol skaia E, Sochilina E, Faddeeva M. [The inhibition enzymatic hydrolysis of acetylthiocholine by acetylcholinesterase using principal alkaloids isolated from celandine and macleya and their derivatives]. Tsitologiia. 2001;43:1046-50 pubmed
    ..hydrolysis of acetylthiocholine by human erythrocyte acetylcholinesterase of principal alkaloids isolated from Chelidonium majus L...
  17. Yang G, Lee K, Lee M, Kim S, Ham I, Choi H. Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin lesions in NC/Nga mice. J Ethnopharmacol. 2011;138:398-403 pubmed publisher
    b>Chelidonium majus (CM) has traditionally been used for treatment of various inflammatory diseases including atopic dermatitis (AD). However its action on atopic dermatitis (AD) is unclear...
  18. Dobrucka R, Dlugaszewska J, Kaczmarek M. Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract. Biomed Microdevices. 2017;20:5 pubmed publisher
    The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties...
  19. Koriem K, Arbid M, Asaad G. Chelidonium majus leaves methanol extract and its chelidonine alkaloid ingredient reduce cadmium-induced nephrotoxicity in rats. J Nat Med. 2013;67:159-67 pubmed publisher
    ..The natriuretic and antidiuretic effects of methyl alcohol extracts of Chelidonium majus L. (C. majus) leaves were evaluated in kidney of cadmium-intoxicated rats...
  20. Tütüncü Konyar S, Ozturk N, Dane F. Occurrence, types and distribution of calcium oxalate crystals in leaves and stems of some species of poisonous plants. Bot Stud. 2014;55:32 pubmed publisher
    ..Aristolochiaceae), Humulus lupulus L. (Cannabaceae), Saponaria officinalis L. (Caryophyllaceae), Chelidonium majus L. (Papaveraceae), Hypericum perforatum L. (Hypericaceae), Tribulus terrestris L...
  21. Meng F, Zuo G, Hao X, Wang G, Xiao H, Zhang J, et al. Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates. J Ethnopharmacol. 2009;125:494-6 pubmed publisher
    The herb of Chelidonium majus Linn is known to possess a variety of biological activities and applied in the therapy of various infectious diseases...
  22. Kunzel J, Geisler K, Hoffmann I, Muller A, Beckmann M, Dittrich R. Myometrial response to neurotropic and musculotropic spasmolytic drugs in an extracorporeal perfusion model of swine uteri. Reprod Biomed Online. 2011;23:132-40 pubmed publisher
    ..Denaverine and pethidine in particular may in the future be able to play an important role in improving the pregnancy rate after IVF. ..
  23. Philchenkov A, Kaminskyy V, Zavelevich M, Stoika R. Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects. Toxicol In Vitro. 2008;22:287-95 pubmed
    ..chelidonine (CHE) and sanguinarine (SAN), two structurally related benzophenanthridine alkaloids isolated from Chelidonium majus L. (Papaveraceae), were compared...
  24. Capistrano I R, Wouters A, Lardon F, Gravekamp C, Apers S, Pieters L. In vitro and in vivo investigations on the antitumour activity of Chelidonium majus. Phytomedicine. 2015;22:1279-87 pubmed publisher
    b>Chelidonium majus L. (Papaveraceae) (greater celandine) is a medicinal herb that is widely spread in Europe. Antitumoural activity has been reported for C. majus extracts. To investigate the antitumour activity of a C...
  25. Nawrot R, Lippmann R, Matros A, Musidlak O, Nowicki G, Mock H. Proteomic comparison of Chelidonium majus L. latex in different phases of plant development. Plant Physiol Biochem. 2017;112:312-325 pubmed publisher
    b>Chelidonium majus L. (Papaveraceae) latex is used in traditinonal folk medicine to treat papillae, warts, condylomas, which are visible effects of human papilloma virus (HPV) infections...
  26. Song J, Yang H, Pyo S, Jung I, Yi S, Yun Y. Immunomodulatory activity of protein-bound polysaccharide extracted from Chelidonium majus. Arch Pharm Res. 2002;25:158-64 pubmed
    ..from natural sources, the protein-bound polysaccharide, CM-Ala, has been isolated from the water extract of Chelidonium majus L. (Papaveraceae)...
  27. Zhou Q, Liu Y, Wang X, Di X. Microwave-assisted extraction in combination with capillary electrophoresis for rapid determination of isoquinoline alkaloids in Chelidonium majus L. Talanta. 2012;99:932-8 pubmed publisher
    ..by capillary electrophoresis (CE) was developed for the quantification of eight isoquinoline alkaloids in Chelidonium majus L. (Ch. majus)...
  28. Teschke R, Glass X, Schulze J. Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports. Regul Toxicol Pharmacol. 2011;61:282-91 pubmed publisher
    Toxic liver injury due to the herb Greater Celandine (GC) (Chelidonium majus L.) has been assumed in patients originating from various European countries and created concern...
  29. Hardeman E, Van Overbeke L, Ilegems S, Ferrante M. Acute hepatitis induced by greater celandine (Chelidonium majus). Acta Gastroenterol Belg. 2008;71:281-2 pubmed
  30. Shin H, Kim H, Kim S, Chung W, Kim S, Um J. Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-?B and caspase-1 in HMC-1 cells. Immunopharmacol Immunotoxicol. 2011;33:614-9 pubmed publisher
    Chelidonic acid (CA) is a ?-pyrone which is contained in the rhizome of Chelidonium majus L...
  31. Noureini S, Esmaeili H, Abachi F, Khiali S, Islam B, Kuta M, et al. Selectivity of major isoquinoline alkaloids from Chelidonium majus towards telomeric G-quadruplex: A study using a transition-FRET (t-FRET) assay. Biochim Biophys Acta Gen Subj. 2017;1861:2020-2030 pubmed publisher
    Natural bioproducts are invaluable resources in drug discovery. Isoquinoline alkaloids of Chelidonium majus constitute a structurally diverse family of natural products that are of great interest, one of them being their selectivity for ..
  32. Pantano F, Mannocchi G, Marinelli E, Gentili S, Graziano S, Busardò F, et al. Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature. Eur Rev Med Pharmacol Sci. 2017;21:46-52 pubmed
    The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper...
  33. Paul A, Bishayee K, Ghosh S, Mukherjee A, Sikdar S, Chakraborty D, et al. Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways. Zhong Xi Yi Jie He Xue Bao. 2012;10:1025-38 pubmed
    To evaluate the role of chelidonine isolated from ethanolic extract of Chelidonium majus in inducing apoptosis in HeLa cells and to assess the main signalling pathways involved...
  34. Pan J, Yang Y, Zhang R, Yao H, Ge K, Zhang M, et al. Enrichment of chelidonine from Chelidonium majus L. using macroporous resin and its antifungal activity. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1070:7-14 pubmed publisher
    b>Chelidonium majus L. (greater celandine) has been used as an herbal medicine for several centuries. This study investigated an efficient method to purify chelidonine from the extract of C. majus L...
  35. Deng A, Zhang H, Li Q, Li Z, Zhang Z, Wu L, et al. Six scalemic mixtures of 6-monosubstituted dihydrobenzophenanthridine alkaloids from Chelidonium majus and optically active structures of enantiomers. Phytochemistry. 2017;144:159-170 pubmed publisher
    ..alkaloids were separated as corresponding six scalemic mixtures from the aerial part of Chelidonium majus...
  36. Wei Q, Zhao M, Li X. Extraction of Chelerythrine and its Effects on Pathogenic Fungus Spore Germination. Pharmacogn Mag. 2017;13:600-606 pubmed publisher
    ..One potential botanical pesticide is chelerythrine, a main alkaloid of Chelidonium majus L., which has high antitumor, fungistasis, and antiphlogosis bioactivity.
  37. Nawrot R, Barylski J, Lippmann R, Altschmied L, Mock H. Combination of transcriptomic and proteomic approaches helps to unravel the protein composition of Chelidonium majus L. milky sap. Planta. 2016;244:1055-1064 pubmed
    A novel annotated Chelidonium majus L. transcriptome database composed of 23,004 unique coding sequences allowed to significantly improve the sensitivity of proteomic C...
  38. Habermehl D, Kammerer B, Handrick R, Eldh T, Gruber C, Cordes N, et al. Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. BMC Cancer. 2006;6:14 pubmed
    ..drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L...
  39. Tcherniuk S, Chesnokova O, Oleinikov I, Potopalsky A, Oleinikov A. Anti-malarial effect of semi-synthetic drug amitozyn. Malar J. 2015;14:425 pubmed publisher
    ..The semi-synthetic drug amitozyn, obtained through alkylation of major celandine (Chelidonium majus) alkaloids with N,N'N'-triethylenethiophosphoramide (ThioTEPA), is a widely used Eastern European folk ..
  40. Pavel A, Vlahovici A, Trifan M, Băra I, Creanga D. [Magnetic liquid influence upon some plant species of pharmaceutical interest]. Rev Med Chir Soc Med Nat Iasi. 2001;105:565-9 pubmed
    ..and Chelidonium majus L...
  41. Nadova S, Miadokova E, Alfoldiova L, Kopaskova M, Hasplova K, Hudecova A, et al. Potential antioxidant activity, cytotoxic and apoptosis-inducing effects of Chelidonium majus L. extract on leukemia cells. Neuro Endocrinol Lett. 2008;29:649-52 pubmed
    The purpose of this study was to assess whether a methanol extract isolated from the greater celandine Chelidonium majus L...
  42. Paul A, Das J, Das S, Samadder A, Khuda Bukhsh A. Poly (lactide-co-glycolide) nano-encapsulation of chelidonine, an active bioingredient of greater celandine (Chelidonium majus), enhances its ameliorative potential against cadmium induced oxidative stress and hepatic injury in mice. Environ Toxicol Pharmacol. 2013;36:937-47 pubmed publisher
    ..Expression pattern of certain inflammatory and apoptotic signal proteins also indicated better hepato-protective abilities of nano-chelidonine, making it a more suitable protective drug than chelidonine against cadmium toxicity in mice...
  43. Kaminskyy V, Kulachkovskyy O, Stoika R. A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids. Toxicol Lett. 2008;177:168-81 pubmed publisher
  44. Gu Y, Qian D, Duan J, Wang Z, Guo J, Tang Y, et al. Simultaneous determination of seven main alkaloids of Chelidonium majus L. by ultra-performance LC with photodiode-array detection. J Sep Sci. 2010;33:1004-9 pubmed publisher
    ..alkaloids, protopine, chelidonine, coptisine, stylopine, sanguinarine, berberine, and chelerythrine, in Chelidonium majus L. (Ch. majus) samples by ultra-performance LC method with photodiode array detection is described...
  45. Gerencer M, Turecek P, Kistner O, Mitterer A, Savidis Dacho H, Barrett N. In vitro and in vivo anti-retroviral activity of the substance purified from the aqueous extract of Chelidonium majus L. Antiviral Res. 2006;72:153-6 pubmed
    We have isolated a substance with anti-retroviral activity from the freshly prepared crude extract of Chelidonium majus L...
  46. van Noordwijk J. ["Dosis solum facit venenum" also for herbal products]. Ned Tijdschr Geneeskd. 2002;146:100-2 pubmed
    A report of severe hepatitis due to the use of material from the plant Chelidonium majus, reminds us that herbal products can be much more life-threatening than many people realise...
  47. Petruczynik A, Gadzikowska M, Waksmundzka Hajnos M. Optimization of the separation of some Chelidonium maius L. alkaloids by reversed phase high-performance liquid chromatography using cyanopropyl bonded stationary phase. Acta Pol Pharm. 2002;59:61-4 pubmed
    ..method using two stationary phases: RP-18 and cyanopropyl silica for the analysis of some alkaloids in Chelidonium maius L. extracts is performed...
  48. De Smet P. Safety concerns about kava not unique. Lancet. 2002;360:1336 pubmed
  49. Buzuk G, Lovkova M, Sokolova S, Tiutekin I. [Genetic aspects of the relationship between isoquinoline alkaloids and mineral elements in greater celandine (Chelidonium majus L.)]. Prikl Biokhim Mikrobiol. 2003;39:37-42 pubmed
    ..Mathematical models describing the regulation of isoquinoline metabolism by some of the mineral elements were obtained in the analytical form. The results suggest that this process is genetically determined...
  50. Saglam H, Arar G. Cytotoxic activity and quality control determinations on Chelidonium majus. Fitoterapia. 2003;74:127-9 pubmed
    The quality control determinations on herba and radix Chelidonii prepared from Chelidonium majus L., growing wildly in Bursa, Uluda? surroundings, have been conducted according to DAB 9...
  51. Kruglova E, Ermak E, Soloshchuk T, Potopal skiĭ A, Potopal skaia I. [Berberine and amitozine binding with calf thymus DNA]. Ukr Biokhim Zh (1999). 2005;77:70-6 pubmed
    ..6 x 10(3)-10(4) M(-1)). Competitive binding of berberine to DNA in presence of ethidium bromide has been investigated as well. It has been shown that it competes with berberine for DNA binding sites...
  52. Goryluk A, Rekosz Burlaga H, Błaszczyk M. Isolation and characterization of bacterial endophytes of Chelidonium majus L. Pol J Microbiol. 2009;58:355-61 pubmed
    The aim of this study was to isolate and identify endophytic bacteria from stems of Chelidonium majus L. (greater celandine) and to evaluate their antifungal properties. In total, 34 bacterial endophyte strains were isolated...
  53. Kamins kyĭ V, Kryv iak N, Lutsyk M, Stoika R. [Effect of alkaloids from celandine on calcium accumulation and oxidative phosphorylation in mitochondria depending on their DNA intercalating properties]. Ukr Biokhim Zh (1999). 2006;78:73-8 pubmed
    The effect of principal alkaloids (sanguinarine, chelerythrine, coptisine, chelidonine) of greater celandine Chelidonium majus L., as well as the alkaloids from Colchicum autumnale L...
  54. Zhang Z, Guo Y, Wei X. [Screen for natural benzylisoquinoline alkaloids against tumor]. Zhongguo Zhong Yao Za Zhi. 2011;36:2684-8 pubmed
    ..To search for natural benzylisoquinoline alkaloids against tumor...
  55. Nawrot R. Defense-related Proteins from Chelidonium majus L. as Important Components of its Latex. Curr Protein Pept Sci. 2017;18:864-880 pubmed publisher
    ..most recent research on plant pathogenesis- and defenserelated proteins from latex-bearing medicinal plant Chelidonium majus (Papaveraceae) in the context of its importance for latex activity, function, pharmacological activities, ..
  56. Moro P, Cassetti F, Giugliano G, Falce M, Mazzanti G, Menniti Ippolito F, et al. Hepatitis from Greater celandine (Chelidonium majus L.): review of literature and report of a new case. J Ethnopharmacol. 2009;124:328-32 pubmed publisher
    ..Nevertheless, use of medicinal plants can have unwanted, negative effects. By means of the description of an adverse reaction to a herbal remedy, we highlight the need for better efficacy-toxicity studies on these products...
  57. Cahlíková L, Opletal L, Kurfürst M, Macakova K, Kulhánková A, Hostálková A. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat Prod Commun. 2010;5:1751-4 pubmed
    The roots and aerial parts of Chelidonium majus L. were extracted with EtOH and fractionated using CHCl3 and EtOH...
  58. Zuo G, Meng F, Han J, Hao X, Wang G, Zhang Y, et al. In vitro activity of plant extracts and alkaloids against clinical isolates of extended-spectrum ?-lactamase (ESBL)-producing strains. Molecules. 2011;16:5453-9 pubmed publisher
    ..Their MIC values ranged between 1.56-12.50 mg/mL. The most active plant extract was Chelidonium majus L. (MIC = 1.56 mg/mL)...
  59. Jankovics T, Bai Y, Kovács G, Bardin M, Nicot P, Toyoda H, et al. Oidium neolycopersici: intraspecific variability inferred from amplified fragment length polymorphism analysis and relationship with closely related powdery mildew fungi infecting various plant species. Phytopathology. 2008;98:529-40 pubmed publisher
    ..The relationship between O. neolycopersici and powdery mildew anamorphs infecting Aquilegia vulgaris, Chelidonium majus, Passiflora caerulea, and Sedum alboroseum was also investigated...
  60. Kim D, Lee J, Park S, Oh S, Kim S, Kim D, et al. 6-Acetonyl-5,6-dihydrosanguinarine (ADS) from Chelidonium majus L. triggers proinflammatory cytokine production via ROS-JNK/ERK-NF?B signaling pathway. Food Chem Toxicol. 2013;58:273-9 pubmed publisher
    b>Chelidonium majus L. is an herbal plant that is commonly used in Western phytotherapy and traditional Chinese medicine for diuretic, antitussive, eye-regenerative, anti-osteoporotic, and radioprotective purposes...
  61. Clayton R, Turner R. Cosmetic surgery: who needs surgeons when you've got creams?. Br J Dermatol. 2007;156:1383-4 pubmed
  62. Rifai K, Flemming P, Manns M, Trautwein C. [Severe drug hepatitis caused by Chelidonium]. Internist (Berl). 2006;47:749-51 pubmed
    ..Other causes of acute hepatitis were excluded. Therefore, the ingestion of a Chelidonium-containing preparation (celandine) was thought to be responsible for the hepatitis...
  63. Lanvers Kaminsky C, Nolting D, Köster J, Schröder A, Sandkötter J, Boos J. In-vitro toxicity of Ukrain against human Ewing tumor cell lines. Anticancer Drugs. 2006;17:1025-30 pubmed
    ..compared the cytotoxicity of Ukrain with the cytotoxicity of N,N',N''-triethylenethiophosphoramide (thioTEPA), Chelidonium majus L. alkaloids, doxorubicin, cyclophosphamide and etoposide against four human Ewing tumor cell lines...
  64. Teschke R, Glass X, Schulze J, Eickhoff A. Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from Europe. Eur J Gastroenterol Hepatol. 2012;24:270-80 pubmed publisher
    In 21 published case reports, the use of the herb Greater Celandine (GC) (Chelidonium majus L.) has been causally related to liver injury, but a variety of confounding variables were evident that might have offset causality...
  65. El Readi M, Eid S, Ashour M, Tahrani A, Wink M. Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids. Phytomedicine. 2013;20:282-94 pubmed publisher
    ..This study demonstrates that chelidonine and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzo[c]phenanthridine alkaloids, has the ability to overcome MDR of ..
  66. Shin M, Jang M, Chang H, Lim S, Han S, Park H, et al. Modulation of Chelidonii herba on glycine-activated and glutamate-activated ion currents in rat periaqueductal gray neurons. Clin Chim Acta. 2003;337:93-101 pubmed
    ..Chelidonii herba is classified as Papaver somniferum L. Aqueous extract from C. herba is traditionally used for disorders with symptoms like pain, bloating, abdominal cramp after meals...
  67. Havelek R, Seifrtova M, Královec K, Krocova E, Tejkalova V, Novotny I, et al. Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells. Phytomedicine. 2016;23:253-66 pubmed publisher
    ..Collectively, the data indicate that chelidonine and homochelidonine are potent inducers of cell death in cancer cell lines, highlighting their potential relevance in leukemic cells. ..
  68. Cho K, Yoo I, Kim W. 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. Biol Pharm Bull. 2006;29:2317-20 pubmed
    Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE)...
  69. Zhang M, Liang H, Gao D, Zhang B, Li X, Guo X. [Characteristics of 23 species of weed in northeast of China hyperaccumulating PAHs in contaminated soils]. Huan Jing Ke Xue. 2011;32:3088-93 pubmed
    ..Potentilla aiscolor B. and Chelidonium majus L. were all higher than 1, which were 1.01, 4.98, 38.24 respectively...
  70. Tarantino G, Pezzullo M, Di Minno M, Milone F, Pezzullo L, Milone M, et al. Drug-induced liver injury due to "natural products" used for weight loss: a case report. World J Gastroenterol. 2009;15:2414-7 pubmed
    ..The true incidence of phytotherapy-related hepatotoxicity and its pathogenic mechanisms are largely unknown. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies...
  71. Düllmann J, Van Damme E, Peumans W, Ziesenitz M, Schumacher U. Lectin histochemistry of the rat lymph node: visualisation of stroma, blood vessels, sinuses, and macrophages. A contribution to the concept of an immune accessory role of sinus-lining endothelia. Acta Histochem. 2002;104:77-83 pubmed
    The lectin Chelidonium majus agglutinin (CMA) was previously shown to visualise endothelia of all blood vessels and those lining sinuses of red pulp, stromal reticular meshwok (RM) and dendritic cells of lymphatic follicles in white pulp ..
  72. Kulp M, Bragina O, Kogerman P, Kaljurand M. Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L. J Chromatogr A. 2011;1218:5298-304 pubmed publisher
    ..native fluorescence (UV-LEDIF) detection for the determination of isoquinoline alkaloids in extracts of Chelidonium majus L. Samples were extracted with acidic methanol and the extracts were directly analysed by CE...
  73. Li X, Yao J, Zhou Z, Shen J, Ru H, Liu X. Activity of the chelerythrine, a quaternary benzo[c]phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius. Parasitol Res. 2011;109:247-52 pubmed publisher
    ..In the present study, bioactivity-guide fractionation was employed to identify active compound from Chelidonium majus L. against D. intermedius...
  74. Buzuk G, Lovkova M, Sokolova S, Tyutekin Y. Evaluation of the correlation and regression relationships between the concentrations of alkaloids and chemical elements in individual greater celandine (Chelidonium majus L.) plants. Dokl Biol Sci. 2002;387:562-4 pubmed
  75. Janovska M, Kubala M, Simanek V, Ulrichova J. Fluorescence of sanguinarine: spectral changes on interaction with amino acids. Phys Chem Chem Phys. 2010;12:11335-41 pubmed publisher
    ..We have also demonstrated that spectral change analysis can aid investigation of SG/DHSG interactions with proteins and we were able to identify SG(+)-binding site on Na(+)/K(+)-ATPase...
  76. Sun N, Yu L. [Determination of chelerythrine in Chelidonium majus by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2009;34:2918-9 pubmed
    To develop an HPLC method for determination of the content of chelerythrine in Chelidonium majus.