paeonia

Summary

Summary: A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.

Top Publications

  1. Chen F, Lu H, Jiang Y. Purification of paeoniflorin from Paeonia lactiflora Pall. by high-speed counter-current chromatography. J Chromatogr A. 2004;1040:205-8 pubmed
    ..the first time for the preparative separation and purification of paeoniflorin from the Chinese medicinal plant Paeonia lactiflora Pall...
  2. Lee S, Kwon Y, Son K, Kim H, Heo M. Antioxidative constituents from Paeonia lactiflora. Arch Pharm Res. 2005;28:775-83 pubmed
    The ethanol extract of the peony root (Paeonia Lactiflora Pall, Paeoniaceae) as well as its major active components including gallic acid and methyl gallate were evaluated for their protective effects against free radical generation and ..
  3. Kim S, Lee M, Lee K, Sung S, Kim J, Kim Y. Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro. J Enzyme Inhib Med Chem. 2009;24:1138-40 pubmed publisher
    The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H(2)O(2)...
  4. Ou T, Wu C, Hsu J, Chyau C, Lee H, Wang C. Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. J Ethnopharmacol. 2011;135:162-72 pubmed publisher
    Extracts of Paeonia lactiflora Pall (RPA), a traditional Chinese medicines has been shown to treat cancers.
  5. Wu S, Wu D, Chen Y. Chemical constituents and bioactivities of plants from the genus Paeonia. Chem Biodivers. 2010;7:90-104 pubmed publisher
  6. Sun W, Wei W, Wu L, Gui S, Wang H. Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2007;112:514-23 pubmed
    b>Paeonia lactiflora and Astragalus membranaceus are two popular traditional Chinese medicines, commonly used in Chinese herb prescription to treat liver disease...
  7. Sun W, Wang L, Liu H, Li X, Wei W. A standardized extract from Paeonia lactiflora and Astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats. Int J Mol Med. 2012;29:491-8 pubmed publisher
    b>Paeonia lactiflora and Astragalus membranaceus are two popular traditional Chinese medicines, commonly used in Chinese herb prescription to treat liver disease...
  8. Xiao L, Wang Y, Liu J, Luo X, Ye Y, Zhu X. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Life Sci. 2005;78:413-20 pubmed
    ..Transient MCAO also induced impairments in TP and performance in the water maze. Treatment with PF was able to reverse or alleviate these impairments. These results indicate that PF may be effective for treatment of stroke...
  9. Zhang W, Dai S. Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol. 2012;14:27-31 pubmed publisher
    b>Paeonia lactiflora Pallas, also named Chinese Paeony, is a Chinese herb. A decoction of its root has been used to treat painful or inflammatory disorders in traditional Chinese medicine...

More Information

Publications65

  1. Nizamutdinova I, Jin Y, Kim J, Yean M, Kang S, Kim Y, et al. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med. 2008;74:14-8 pubmed publisher
    ..this study was to investigate the effects of paeoniflorin (PF) and paeonol (PN), the main active compounds of the Paeonia albiflora Pallas, on myocardial ischemia and reperfusion (I/R)-induced injury in Sprague-Dawley rats IN VIVO...
  2. Baumgartner R, Steinmann D, Heiss E, Atanasov A, Ganzera M, Stuppner H, et al. Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. J Nat Prod. 2010;73:1578-81 pubmed publisher
    ..assay with human recombinant PTP1B 1,2,3,4,6-penta-O-galloyl-D-glucopyranose was isolated from the roots of Paeonia lactiflora as an inhibitor of PTP1B, with an IC(50) value of 4.8 ?M...
  3. Ding H, Chou T, Lin R, Chan L, Wang G, Liang C. Antioxidant and antimelanogenic behaviors of Paeonia suffruticosa. Plant Foods Hum Nutr. 2011;66:275-84 pubmed publisher
    Antioxidant properties of eight Paeonia suffruticosa (Ps) extracts (Ps-1 to Ps-8) were evaluated. The respective half maximally effective concentration (EC(50)) values of Ps-1 ~ 8 were 10.0, 9.8, 63.6, >100, 3.8, 85.1, 6.9, and 0...
  4. Li C, Yazawa K, Kondo S, Mukudai Y, Sato D, Kurihara Y, et al. The root bark of Paeonia moutan is a potential anticancer agent in human oral squamous cell carcinoma cells. Anticancer Res. 2012;32:2625-30 pubmed
    ..The aim of this study was to determine the antitumor activity of the root bark of Paeonia moutan (RBPM) in human squamous cell carcinoma (OSCC) cells...
  5. Shu Q, Wischnitzki E, Liu Z, Ren H, Han X, Hao Q, et al. Functional annotation of expressed sequence tags as a tool to understand the molecular mechanism controlling flower bud development in tree peony. Physiol Plant. 2009;135:436-49 pubmed publisher
    Tree peony (Paeonia suffruticosaAndrews) is an important medicinal and ornamental plant. In China, its root bark is an important ingredient for traditional Chinese medicine...
  6. Shu Q, Wang L, Wu J, Du H, Liu Z, Ren H, et al. Analysis of the formation of flower shapes in wild species and cultivars of tree peony using the MADS-box subfamily gene. Gene. 2012;493:113-23 pubmed publisher
    Tree peony (Paeonia suffricotisa) cultivars have a unique character compared with wild species; the stamen petalody results in increased whorls of petals and generates different flower forms, which are one of the most important traits ..
  7. Zhang J, Shu Q, Liu Z, Ren H, Wang L, De Keyser E. Two EST-derived marker systems for cultivar identification in tree peony. Plant Cell Rep. 2012;31:299-310 pubmed publisher
    Tree peony (Paeonia suffruticosa Andrews), a woody deciduous shrub, belongs to the section Moutan DC. in the genus of Paeonia of the Paeoniaceae family...
  8. Wang R, Chou G, Zhu E, Wang Z, Bi K. A new phenolic glycoside from the roots of Paeonia veitchii. J Asian Nat Prod Res. 2006;8:277-80 pubmed
    From the roots of Paeonia veitchii Lynch., a new phenolic glycoside, 2-O-[alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranoside]-benzaldehyde (1) was isolated together with seven known phenolic compounds...
  9. Park H, Jo S, Jung U, Yee S. Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM. Phytother Res. 2008;22:36-42 pubmed
    ..fraction to the total water extract of a mixture of three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix...
  10. Zeng J, Dou Y, Guo J, Wu X, Dai Y. Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice. Phytomedicine. 2013;20:753-9 pubmed publisher
    Paeoniflorin (PF), the major active constituent of Paeonia lactiflora Pallas, has previously been reported to alleviate hepatic fibrosis. Whether and how it affects renal fibrosis was evaluated in the present study...
  11. Mao Q, Huang Z, Ip S, Che C. Antidepressant-like effect of ethanol extract from Paeonia lactiflora in mice. Phytother Res. 2008;22:1496-9 pubmed publisher
    The present study investigated the antidepressant effect of ethanol extract of Paeonia lactiflora (EPL) in mice using forced swim test, tail suspension test, open-field test and reserpine test...
  12. Lee B, Shin Y, Bae E, Han S, Kim J, Kang S, et al. Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch Pharm Res. 2008;31:445-50 pubmed publisher
    The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan...
  13. Dong H, Liu Z, Song F, Yu Z, Li H, Liu S. Structural analysis of monoterpene glycosides extracted from Paeonia lactiflora Pall. using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and high-performance liquid chromatography/electrospray ionization tandem . Rapid Commun Mass Spectrom. 2007;21:3193-9 pubmed
    ..Then, the extracts of the traditional Chinese medicine Paeonia lactiflora Pall...
  14. Hayes P, Lehmann R, Penman K, Bone K, Kitching W, De Voss J. RP-HPLC detection of a sulphiting-induced artefact from paeoniflorin in dried roots of Paeonia lactiflora. Phytochem Anal. 2006;17:251-4 pubmed
    Paeoniflorin is one of the bioactive ingredients of the roots of Paeonia lactiflora (Paeoniaceae). A comparative study of processed and non-processed commercial samples of dried roots of P...
  15. Choi Y, Yoo H, Noh I, Lee J, Park J, Choi W, et al. Bioassay-guided isolation of novel compound from Paeonia suffruticosa Andrews roots as an IL-1? inhibitor. Arch Pharm Res. 2012;35:801-5 pubmed publisher
    ..7 cells, oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester (1) was isolated from the roots of Paeonia suffruticosa Andrews as an inhibitor of IL-1? with an IC(50) value of 56 ?M...
  16. Xie X, Yu C, Xu H, Wang S, Wang D, Zhang L, et al. [Quality evaluation of prepared slices of Paeonia lactiflon--determination of paeoniflorin by HPLC]. Zhongguo Zhong Yao Za Zhi. 2004;29:759-62 pubmed
    To establish the quality criteria of the prepared slices of Paeonia lactiflon.
  17. Koo Y, Kim J, Koo J, Kang S, Bae K, Kim Y, et al. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Pharmazie. 2010;65:624-8 pubmed
    ..Dry roots of Paeonia lactiflora and dry root bark of P...
  18. Li C, Du H, Wang L, Shu Q, Zheng Y, Xu Y, et al. Flavonoid composition and antioxidant activity of tree peony (Paeonia section moutan) yellow flowers. J Agric Food Chem. 2009;57:8496-503 pubmed publisher
    ..This work is valuable for elucidation of phenolic composition in tree peony flowers and for further utilization of them as functional food and medicine materials...
  19. Zhang J, Wang J, Xia T, Zhou S. DNA barcoding: species delimitation in tree peonies. Sci China C Life Sci. 2009;52:568-78 pubmed publisher
    ..paper we exemplify the necessity of adopting a phylogenetic concept of species in DNA barcoding for tree peonies (Paeonia sect. Moutan)...
  20. Li L, Cheng F, Zhang Q. Microsatellite markers for the Chinese herbaceous peony Paeonia lactiflora (Paeoniaceae). Am J Bot. 2011;98:e16-8 pubmed publisher
    ..Microsatellite (simple sequence repeat, SSR) primers were developed for the Chinese peony, P. lactiflora, to investigate the diversity within Chinese peony germplasm resources...
  21. Sun W, Wei W, Gui S, Wu L, Wang H. Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by bacillus Calmette-Guérin and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol. 2008;103:143-9 pubmed publisher
    b>Paeonia lactiflora and Astragalus membranaceus are two popular traditional Chinese medicines, commonly used in Chinese herb prescription to treat liver disease. The extract from the roots of P. lactiflora and A...
  22. Lin T, Wang K, Lin C, Chiang L, Chang J. Anti-viral activity of water extract of Paeonia lactiflora pallas against human respiratory syncytial virus in human respiratory tract cell lines. Am J Chin Med. 2013;41:585-99 pubmed publisher
    b>Paeonia lactiflora Pallas (P. lactiflora, Ranunculaceae) is a common ingredient of Sheng-Ma-Ge-Gen-Tang (SMGGT; Shoma-kakkon-to) and Ge-Gen-Tang (GGT; kakkon-to)...
  23. Ngan L, Moon J, Shibamoto T, Ahn Y. Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori. J Agric Food Chem. 2012;60:9062-73 pubmed publisher
    ..benzoic acid (BA), methyl gallate (MG), and 1,2,3,4,6-penta-O-galloyl-?-d-glucopyranose (PGG) identified in Paeonia lactiflora root, structurally related compounds, and four antibiotics toward three reference strains and four ..
  24. Wang X, Cheng C, Sun Q, Li F, Liu J, Zheng C. Isolation and purification of four flavonoid constituents from the flowers of Paeonia suffruticosa by high-speed counter-current chromatography. J Chromatogr A. 2005;1075:127-31 pubmed
    ..and kaempferol-7-O-glucoside have been isolated and purified for the first time from the flowers of Paeonia suffruticosa by high-speed counter-current chromatography with a two-phase solvent system composed of ethyl ..
  25. Huang X, Zhu W, Dai S, Gai S, Zheng G, Zheng C. The involvement of mitochondrial phosphate transporter in accelerating bud dormancy release during chilling treatment of tree peony (Paeonia suffruticosa). Planta. 2008;228:545-52 pubmed publisher
    A cDNA clone was isolated from tree peony (Paeonia suffruticosa) subtractive cDNA library of burst buds and characterized with regard to its sequence, expression in response to chilling treatment during the release of bud dormancy, and ..
  26. Braca A, Kiem P, Yen P, Nhiem N, Quang T, Cuong N, et al. New monoterpene glycosides from Paeonia lactiflora. Fitoterapia. 2008;79:117-20 pubmed publisher
    ..3), together with two known monoterpene glycosides, paeoniflorin (4) and benzoylpaeoniflorin (5), were isolated from the roots of Paeonia lactiflora. Their structures were established on the basis of spectral and chemical evidence.
  27. Pan L, Dai M. Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression. Phytomedicine. 2009;16:1027-32 pubmed publisher
    Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of the radix of Paeonia suffruticosa, has been reported to have a beneficial effect in prevention and treatment of cardiovascular diseases...
  28. Zhao G, Shen Y, Ma J, Li F, Shi X. [Protection of polysaccharides-2b from mudan cortex of Paeonia suffruticosa andr on diabetic cataract in rats]. Zhongguo Zhong Yao Za Zhi. 2007;32:2036-9 pubmed
    To observe the the protective effection of polysaccharides-2b of mudan cortex of Paeonia suffruticosa andr (PSM2b) on diabetic cataract.
  29. Yuan J, Cheng F, Zhou S. Genetic structure of the tree peony (Paeonia rockii) and the Qinling Mountains as a geographic barrier driving the fragmentation of a large population. PLoS ONE. 2012;7:e34955 pubmed publisher
    ..In this study, the genetic differentiation and genetic structure of Paeonia rockii and the role of the Qinling Mountains as a barrier that has driven intraspecific fragmentation were ..
  30. Ngan L, Moon J, Kim J, Shibamoto T, Ahn Y. Growth-inhibiting effects of Paeonia lactiflora root steam distillate constituents and structurally related compounds on human intestinal bacteria. World J Microbiol Biotechnol. 2012;28:1575-83 pubmed publisher
    The growth-inhibiting activities of Paeonia lactiflora (Paeoniaceae) root steam distillate constituents and structurally related compounds against nine harmful intestinal bacteria and eight lactic acid-producing bacteria were compared ..
  31. Lee S, Yoon M, Park H. Protective effects of Paeonia lactiflora pall on hydrogen peroxide-induced apoptosis in PC12 cells. Biosci Biotechnol Biochem. 2008;72:1272-7 pubmed
    This study was conducted to examine the antioxidative and neuroprotective effects of Paeonia lactiflora pall (PLE). Total phenolic content of PLE was 89.65 mg of gallic acid equivalent per gram of PLE...
  32. Zhao D, Tao J, Han C, Ge J. Flower color diversity revealed by differential expression of flavonoid biosynthetic genes and flavonoid accumulation in herbaceous peony (Paeonia lactiflora Pall.). Mol Biol Rep. 2012;39:11263-75 pubmed publisher
    Herbaceous peony (Paeonia lactiflora Pall.) is an important ornamental plant which contains different flower colors...
  33. Choi C, Choi Y, Cha M, Kim Y, Yon G, Hong K, et al. In vitro BACE-1 inhibitory activity of resveratrol oligomers from the seed extract of Paeonia lactiflora. Planta Med. 2011;77:374-6 pubmed publisher
    ..A new resveratrol oligomer (1) together with eight related components (2- 9) were isolated from the seed extract of Paeonia lactiflora (Paeoniaceae) as active principles responsible for the inhibition of beta-site APP-cleaving enzyme 1 (..
  34. Hong M, Kim J, Na S, Bae H, Shin Y, Kim S, et al. Inhibitory effects of Paeonia suffruticosa on allergic reactions by inhibiting the NF-kappaB/I kappaB-alpha signaling pathway and phosphorylation of ERK in an animal model and human mast cells. Biosci Biotechnol Biochem. 2010;74:1152-6 pubmed
    The root cortex of Paeonia suffruticosa Andrews (PSA), also known as Moutan Cortex, is known to have anti-allergic and anti-inflammatory properties. This study investigates the effect and mechanism of PSA by in vivo and in vitro methods...
  35. Ha D, Tuan D, Thu N, Nhiem N, Ngoc T, Yim N, et al. Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells. Bioorg Med Chem Lett. 2009;19:5556-9 pubmed publisher
    ..In conclusion, our results suggest that these compounds, especially compound 1, may have beneficial roles in glucose metabolism via the AMPK pathway...
  36. Xu W, Zhou L, Ma X, Chen Y, Qin B, Zhai X, et al. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12:2031-7 pubmed
    ..was to investigate the therapeutic effects of the combination of paeoniflorin and albiflorin (CPA) extracted from Paeonia radix on radiation and chemotherapy induced myelosuppression in two animal models: mice and rabbits...
  37. Wang H, Gu W, Chu W, Zhang S, Tang X, Qin G. Monoterpene glucosides from Paeonia lactiflora. J Nat Prod. 2009;72:1321-4 pubmed publisher
    Four new "cage-like" monoterpene glucosides (1-4) were isolated from Paeonia lactiflora. The structures of these compounds were established by spectroscopic methods, mainly 1D and 2D NMR, and mass spectrometric analysis...
  38. Hao Q, Liu Z, Shu Q, Zhang R, De Rick J, Wang L. Studies on Paeonia cultivars and hybrids identification based on SRAP analysis. Hereditas. 2008;145:38-47 pubmed publisher
    Plants of Paeonia are valuable for their ornamental and medicinal values. Genetic relations and hybrids identification among different sections of Paeonia were studied using sequence related amplified polymorphism (SRAP) markers...
  39. Gai S, Zhang Y, Mu P, Liu C, Liu S, Dong L, et al. Transcriptome analysis of tree peony during chilling requirement fulfillment: assembling, annotation and markers discovering. Gene. 2012;497:256-62 pubmed publisher
    Tree peony (Paeonia suffruticosa Andrews) is a well-known horticultural and medicinal plant...
  40. Wu J, Sun W, Hu S, Zhang S, Wei W. A standardized extract from Paeonia lactiflora and Astragalus membranaceus induces apoptosis and inhibits the proliferation, migration and invasion of human hepatoma cell lines. Int J Oncol. 2013;43:1643-51 pubmed publisher
    b>Paeonia lactiflora and Astragalus membranaceus are two traditional Chinese medicines, which are commonly used in Chinese herb prescription to treat liver diseases...
  41. Ding H, Lin H, Chang T. Tyrosinase inhibitors isolated from the roots of Paeonia suffruticosa. J Cosmet Sci. 2009;60:347-52 pubmed
    The inhibition of mushroom tyrosinase by Paeonia suffruticosa root-derived materials was evaluated...
  42. Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, et al. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo. J Neurochem. 2009;109:1648-57 pubmed publisher
    ..This study demonstrated that Paeonia suffruticosa, a traditional medicinal herb, not only inhibited fibril formation of both Abeta(1-40) and Abeta(1-..
  43. Lau C, Chan C, Chan Y, Lau K, Lau T, Lam F, et al. Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol. Phytomedicine. 2007;14:778-84 pubmed
    Cortex Moutan (CM, root bark of Paeonia suffruticosa Andr.) is one of the common herbs found in anti-diabetic traditional Chinese medicine formulae...
  44. Yang H, Ko W, Kim J, Ro H. Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. Fitoterapia. 2004;75:45-9 pubmed
    Paeoniflorin (1), isolated from the methanol extract of Paeonia lactiflora, showed a lowering effect on cholesterol level in the experimentally-induced hyperlipidemic rats...
  45. Lee S, Lee I, Mar W. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells. Arch Pharm Res. 2003;26:832-9 pubmed
    ..The root of Paeonia lactiflora Pall., and the root cortex of Paeonia suffruticosa Andr...
  46. Tanaka T, Fukumori M, Ochi T, Kouno I. Paeonianins A-E, new dimeric and monomeric ellagitannins from the fruits of Paeonia lactiflora. J Nat Prod. 2003;66:759-63 pubmed
    Four new dimeric ellagitannins, paeonianins A-D (2-5), were isolated from the fruits of Paeonia lactiflora, together with a new ellagitannin monomer, paeonianin E (1). Their structures were determined by spectroscopic methods...
  47. Riaz N, Anis I, Malik A, Ahmed Z, Aziz Ur Rehman -, Muhammad P, et al. Paeonins A and B, lipoxygenase inhibiting monoterpene galactosides from Paeonia emodi. Chem Pharm Bull (Tokyo). 2003;51:252-4 pubmed
    ..A and B, new monoterpene galactosides have been isolated from the chloroform-soluble fraction of the roots of Paeonia emodi and showed potent lipoxygenase inhibitory activity...
  48. Hong J, Chung S, Lee J, Kim S, Shin H, Kim H, et al. Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats. Biol Pharm Bull. 2003;26:166-9 pubmed
    b>Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae...
  49. Kim H, Chang E, Cho S, Chung S, Park H, Choi S. Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora. Biosci Biotechnol Biochem. 2002;66:1990-3 pubmed
    ..trans-epsilon-viniferin, gnetin H, and suffruticosol A and B, were isolated and identified from seeds of Paeonia lactiflora...
  50. Kim H, Chang E, Bae S, Shim S, Park H, Rhee C, et al. Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora. Arch Pharm Res. 2002;25:293-9 pubmed
    ..transresveratrol, trans-epsilon-viniferin, gnetin H, suffruticosols A and B, isolated from the seeds of Paeonia lactiflora Pall...
  51. Tong L, Wan M, Zhou D, Gao J, Zhu Y, Bi K. LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang-Min-Ling-Wan. Biomed Chromatogr. 2010;24:1324-31 pubmed publisher
    ..The results provided a meaningful basis for evaluating the clinical applications of traditional Chinese medicine. ..
  52. Wu J, Yao N, Wang D. [Determination of paeoniflorin in rat plasma by HPLC-MS/MS and its pharmacokinetics]. Zhongguo Zhong Yao Za Zhi. 2008;33:2369-73 pubmed
    ..The parameters of C(max), AUC(0 --> tau) and MRT were significantly changed (P < 0.05). Radix Angelicae Sinensis can significantly affect the pharmacokinetics of paeoniflorin, the principal component of Radix Paeoniae Rubra. ..
  53. Men W, Chen Y, Yang Q, Li Y, Gong Z, Weng X, et al. [Study on metabolism of Coptis chinensis alkaloids from different compatibility of Wuji Wan in human intestinal flora]. Zhongguo Zhong Yao Za Zhi. 2013;38:417-21 pubmed
    ..To study the metabolism of berberine and palmatine in prescription compatibility of Wuji Wan in human intestinal flora...
  54. Lu Z, Masaki T, Shoyama Y, Tanaka H. Construction and expression of a single chain Fv fragment against pharmacologically active paeoniflorin in Escherichia coli, and its potential use in an enzyme-linked immunosorbent assay. Planta Med. 2006;72:151-5 pubmed
    ..78 to 25 microg/mL. The results obtained by ELISA employing both the recombinant scFv and the original MAbC31B9 showed a reasonably good agreement with each other...
  55. Du J, Dong B. [Comparative study on clinical efficacy of using methotrexate singly or combined with total glucosides of Paeony in treating rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25:540-2 pubmed
    ..To observe the clinical efficacy of methotrexate (MTX) combined with total glucosides of Peony (TGP) on rheumatoid arthritis (RA)...
  56. Xie W, Ma X, Shao N. [Preliminary study on change of serum proteome in noxious heat blood stasis syndrome treated by radix Paeoniae rubra]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25:520-4 pubmed
    ..To study the effect of red peony root (RPR) on serum proteome in rat suffering from noxious heat with blood stasis Syndrome (NH-BS)...