camptotheca

Summary

Summary: A plant genus of the family NYSSACEAE (sometimes classified in the CORNACEAE family). It is a source of CAMPTOTHECIN.

Top Publications

  1. Oberlies N, Kroll D. Camptothecin and taxol: historic achievements in natural products research. J Nat Prod. 2004;67:129-35 pubmed
    ..Camptothecin, first isolated and identified from Camptotheca acuminata, was found to kill cancer cells uniquely via topoisomerase I poisoning...
  2. Zhang J, Yu Y, Liu D, Liu Z. Extraction and composition of three naturally occurring anti-cancer alkaloids in Camptotheca acuminata seed and leaf extracts. Phytomedicine. 2007;14:50-6 pubmed
    ..Extraction of CPT from Camptotheca acuminata trees remains to be a cost-effective way in the supply equation compared with a total synthesis...
  3. Lorence A, Medina Bolivar F, Nessler C. Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots. Plant Cell Rep. 2004;22:437-41 pubmed
    Camptothecin (CPT) is an anticancer and antiviral alkaloid produced by the Chinese tree Camptotheca acuminata (Nyssaceae) and some other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae...
  4. Sun Y, Luo H, Li Y, Sun C, Song J, Niu Y, et al. Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport. BMC Genomics. 2011;12:533 pubmed publisher
    b>Camptotheca acuminata is a Nyssaceae plant, often called the "happy tree", which is indigenous in Southern China. C...
  5. Kusari S, Zühlke S, Spiteller M. Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis. J Nat Prod. 2011;74:764-75 pubmed publisher
    ..We recently isolated an endophytic fungus, Fusarium solani, from Camptotheca acuminata, capable of biosynthesizing camptothecin (CPT, 1), but this capability substantially decreased on ..
  6. Kim Y, Kim D, Lee S, Lee I. Wound-induced expression of the ferulate 5-hydroxylase gene in Camptotheca acuminata. Biochim Biophys Acta. 2006;1760:182-90 pubmed
    ..We isolated F5H cDNA and genomic DNA from Camptotheca acuminata and investigated the expression pattern of the C. acuminata F5H (CaF5H1) gene in response to wounding...
  7. Pasqua G, Monacelli B, Mulinacci N, Rinaldi S, Giaccherini C, Innocenti M, et al. The effect of growth regulators and sucrose on anthocyanin production in Camptotheca acuminata cell cultures. Plant Physiol Biochem. 2005;43:293-8 pubmed
    ..concentrations of growth regulators and sucrose on anthocyanin production in cell suspension cultures of Camptotheca acuminata Decaisne (Nyssaceae) was described for the first time and qualitatively and quantitatively evaluated...
  8. Pi Y, Liao Z, Jiang K, Huang B, Deng Z, Zhao D, et al. Molecular cloning, characterization and expression of a jasmonate biosynthetic pathway gene encoding allene oxide cyclase from Camptotheca acuminata. Biosci Rep. 2008;28:349-55 pubmed publisher
    ..3.99.6), an essential enzyme in jasmonic acid and its methyl ester biosynthesis, was cloned from Camptotheca acuminata (named as CaAOC), a native medicinal plant species in China...
  9. Yao H, Gong Y, Zuo K, Ling H, Qiu C, Zhang F, et al. Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata. J Plant Physiol. 2008;165:203-13 pubmed
    ..as CaDXR) was isolated and characterized for the first time from a medicinal Nyssaceae plant species, Camptotheca acuminata...

More Information

Publications77

  1. Valletta A, Santamaria A, Pasqua G. CPT accumulation in the fruit and during early phases of plant development in Camptotheca acuminata Decaisne (Nyssaceae). Nat Prod Res. 2007;21:1248-55 pubmed
    We describe the dynamics of camptothecin (CPT) accumulation during the early phases of plant development in Camptotheca acuminata...
  2. Pan X, Chen M, Liu Y, Wang Q, Zeng L, Li L, et al. A new isopentenyl diphosphate isomerase gene from Camptotheca acuminata: cloning, characterization and functional expression in Escherichia coli. DNA Seq. 2008;19:98-105 pubmed publisher
    ..Here we report cloning, characterization and functional expression of a new cDNA encoding IPI from Camptotheca acuminata...
  3. Kusari S, Zühlke S, Spiteller M. Correlations between camptothecin and related metabolites in Camptotheca acuminata reveal similar biosynthetic principles and in planta synergistic effects. Fitoterapia. 2011;82:497-507 pubmed publisher
    ..We analyzed these metabolites in Camptotheca acuminata sampled from Germany and China, using LC-MS/MS and LC-ESI-HRMS/MS, coupled with chemometrics...
  4. Liu W, Wang Z. [Accumulation and localization of camptothecin in young shoot of Camptotheca acuminata]. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao. 2004;30:405-12 pubmed
    ..were investigated using optical, fluorescence and scanning electron microscopy and the camptothecin content in Camptotheca acuminata was analyzed by HPLC. Secretory structure, especially secretory canals were found...
  5. Pan X, Xu H, Liu X, Gao X, Lu Y. Improvement of growth and camptothecin yield by altering nitrogen source supply in cell suspension cultures of Camptotheca acuminata. Biotechnol Lett. 2004;26:1745-8 pubmed
    Nitrate at 70 mM gave the highest biomass of Camptotheca acuminata in suspension culture in MS medium, but a NH4+/NO3- molar ratio of 5:1 (giving a total of 40 mM N) gave the maximum camptothecin yield...
  6. Pasqua G, Monacelli B, Valletta A. Cellular localisation of the anti-cancer drug camptothecin in Camptotheca acuminata Decne (Nyssaceae). Eur J Histochem. 2004;48:321-7 pubmed
    In Camptotheca acuminata, we studied the cellular sites of accumulation of the alkaloid camptothecin (CPT), in both plants grown in the field and those grown in a greenhouse, subjecting the latter to stress (i.e...
  7. Pi Y, Jiang K, Cao Y, Wang Q, Huang Z, Li L, et al. Allene oxide cyclase from Camptotheca acuminata improves tolerance against low temperature and salt stress in tobacco and bacteria. Mol Biotechnol. 2009;41:115-22 pubmed publisher
    ..An AOC gene (defined as CaAOC, Database Accession No. AY863428) had been isolated from Camptotheca acuminata in previous work...
  8. Li S, Yi Y, Wang Y, Zhang Z, Beasley R. Camptothecin accumulation and variations in camptotheca. Planta Med. 2002;68:1010-6 pubmed
    b>Camptotheca (Nyssaceae) is a major source of anticancer camptothecin (CPT). It is imperative to understand CPT accumulation and variations in Camptotheca in order to develop CPT production strategies for endangered germplasm...
  9. Lu D, Dong J, Jin H, Sun L, Xu X, Zhou T, et al. Nitrate reductase-mediated nitric oxide generation is essential for fungal elicitor-induced camptothecin accumulation of Camptotheca acuminata suspension cell cultures. Appl Microbiol Biotechnol. 2011;90:1073-81 pubmed publisher
    ..NO, we examined nitrate reductase (NR) activities and the expression levels of NIA1 and NIA2 genes of Camptotheca acuminata cells treated with PB90, a protein elicitor from Phytophthora boehmeriae...
  10. Liu K, Ding X, Deng B, Chen W. 10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata. Biotechnol Lett. 2010;32:689-93 pubmed publisher
    A new 10-hydroxycamptothecin (HCPT)-producing fungus was isolated from Camptotheca acuminata. The strain was classified as a Xylaria sp. based on the internal transcribed spacer and 18S rDNA gene analysis...
  11. Kusari S, Zühlke S, Spiteller M. An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. J Nat Prod. 2009;72:2-7 pubmed publisher
    ..and characterization of a novel endophytic fungus isolated from the inner bark of the medicinal plant Camptotheca acuminata, which produced 1-3 in rich mycological medium (Sabouraud dextrose broth), under shake-flask ..
  12. Monacelli B, Valletta A, Rascio N, Moro I, Pasqua G. Laticifers in Camptotheca acuminata Decne: distribution and structure. Protoplasma. 2005;226:155-61 pubmed
    In this paper, a system of laticifers in Camptotheca acuminata Decne (Nyssaceae) is described. Laticifers were already present in the leaf primordia of the shoot apex...
  13. Lu H, Gorman E, McKnight T. Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminata. Planta. 2005;221:352-60 pubmed
    The potent anticancer and antiviral compound camptothecin (CPT) is a monoterpene indole alkaloid produced by Camptotheca acuminata...
  14. Kim J, Jeong M, Lee S, Song J. Camptothecin and topotecan inhibit adipocyte differentiation by inducing degradation of PPARγ. Biochem Biophys Res Commun. 2015;463:1122-8 pubmed publisher
    Camptothecin is an anti-cancer drug extracted from Camptotheca acuminata, a tree native to mainland China. Phase III clinical trials for camptothecin have been completed, and it is now used as a chemotherapeutic reagent...
  15. Bracher F, Tremmel T. From Lead to Drug Utilizing a Mannich Reaction: The Topotecan Story. Arch Pharm (Weinheim). 2017;350: pubmed publisher
    ..A prominent example is camptothecin from the Chinese tree Camptotheca acuminata, which shows extraordinary cytotoxic activity based on a specific molecular mode of action (..
  16. Zu Y, Gao C, Wang W, Yang F, Liu Y, Wang M, et al. Characteristics of the microbial community in rhizosphere of Camptotheca acuminata cultured with exotic invasive plant Eupatorium adenophorum. Sci China C Life Sci. 2007;50:22-30 pubmed
    ..tRFLP) combined with 16S rDNA clone library were adopted to investigate the impacts of secretion from Camptotheca acuminata (abbreviated to Ca) roots on the quantities and structure of eukaryotic microbes and bacteria in the ..
  17. Dev S, Dhaneshwar S, Mathew B. Discovery of Camptothecin Based Topoisomerase I Inhibitors: Identification Using an Atom Based 3D-QSAR, Pharmacophore Modeling, Virtual Screening and Molecular Docking Approach. Comb Chem High Throughput Screen. 2016;19:752-763 pubmed
    Camptothecin is a quinoline alkaloid, isolated from the Chinese tree Camptotheca acuminate which exhibits its cytotoxic activity by the inhibition of nuclear enzyme Topoisomerase I (topo I)...
  18. Svenson S, Wolfgang M, Hwang J, Ryan J, Eliasof S. Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101. J Control Release. 2011;153:49-55 pubmed publisher
  19. Chen F, Li W, Jiang L, Pu X, Yang Y, Zhang G, et al. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in production of geraniol in Escherichia coli. J Ind Microbiol Biotechnol. 2016;43:1281-92 pubmed publisher
    ..Here we report the functional characterization of CaGES from Camptotheca acuminata, a camptothecin-producing plant, and its application in production of geraniol in Escherichia coli...
  20. Kumar D, Kumar S, Ayachit G, Bhairappanavar S, Ansari A, Sharma P, et al. Cross-Kingdom Regulation of Putative miRNAs Derived from Happy Tree in Cancer Pathway: A Systems Biology Approach. Int J Mol Sci. 2017;18: pubmed publisher
    ..i>Camptotheca acuminata, a highly important medicinal plant known for its anti-cancer potential was selected to ..
  21. Martino E, Della Volpe S, Terribile E, Benetti E, Sakaj M, Centamore A, et al. The long story of camptothecin: From traditional medicine to drugs. Bioorg Med Chem Lett. 2017;27:701-707 pubmed publisher
    20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree)...
  22. Pan C, Hu Y, Song J, Yi H, Wang L, Yang Y, et al. Effects of 10-hydroxycamptothecin on intrinsic mitochondrial pathway in silkworm BmN-SWU1 cells. Pestic Biochem Physiol. 2016;127:15-20 pubmed publisher
    10-Hydroxycamptothecin (HCPT), a plant alkaloid isolated from Camptotheca acuminate, is known as a planted-derived insecticide, however, the specific mechanism in insect cells is still unclear...
  23. Yang L, Jiang L, Li W, Yang Y, Zhang G, Luo Y. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli. J Ind Microbiol Biotechnol. 2017;44:1431-1441 pubmed publisher
    ..Herein a homomeric GPPS from Camptotheca acuminata, a camptothecin-producing plant, was obtained from 5'- and 3'-rapid amplification of cDNA ends and ..
  24. Wu D, Shi W, Zhao J, Wei Z, Chen Z, Zhao D, et al. Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205. Arch Biochem Biophys. 2016;604:74-85 pubmed publisher
    CPT-11 (irinotecan) is a derivative of camptothecin which is a natural product derived from the Chinese tree Camptotheca acuminta and widely used in antitumor therapy...
  25. Li C, Zhang Y, Zhao C, Ni Y, Wang K, Zhang J, et al. Ultrasonic Assisted-Reflux Synergistic Extraction of Camptothecin and Betulinic Acid from Camptotheca acuminata Decne. Fruits. Molecules. 2017;22: pubmed publisher
    ..synergistic extraction (UARSE) method for extracting camptothecin (CPT) and betulinic acid (BA) from Camptotheca acuminata Decne. fruits has been developed in this study...
  26. Wang L, Li Z, Zhang L, Zhang Y, Mao L, Jiang H. Synthesis, insecticidal activity and inhibition on topoisomerase I of 20(S)-t-Boc-amino acid derivatives of camptothecin. Pestic Biochem Physiol. 2017;139:46-52 pubmed publisher
    Camptothecin (CPT), a quinolone alkaloid extracted from Camptotheca acuminata Decne, exhibits potential insecticidal activities against various insect species...
  27. Ran X, Zhang G, Li S, Wang J. Characterization and antitumor activity of camptothecin from endophytic fungus Fusarium solani isolated from Camptotheca acuminate. Afr Health Sci. 2017;17:566-574 pubmed publisher
    ..Camptothecin (CPT) is a potent drug against cancers, originally from plants. The endophytic fungi could produce the secondary metabolite same as the host and is used as medicine...
  28. Ueno Y, Matsuda H, Mizutani H, Iwamoto T, Okuda M. Involvement of specific transport system on uptake of lactone form of SN-38 in human intestinal epithelial cell line Caco-2. Biol Pharm Bull. 2012;35:54-8 pubmed
    ..These results suggest that apical uptake of SN-38 by Caco-2 is dominantly performed as a lactone form through a specific transporter, which is competitively inhibited by baicalin. ..
  29. Deng S, May B, Zhang A, Lu C, Xue C. Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2013;169:769-82 pubmed publisher
    ..of: Mahonia aquifolium (n = 5), Aloe vera (n = 3), indigo naturalis (n = 2), kukui nut oil (n = 1) and Camptotheca acuminata nut (n = 1). Methodological quality was variable...
  30. Babjak M, Kanazawa A, Anderson R, Greene A. Concise synthesis of 22-hydroxyacuminatine, cytotoxic camptothecinoid from Camptotheca acuminata, by pyridone benzannulation. Org Biomol Chem. 2006;4:407-9 pubmed
  31. Wang L, Wei Y. [Fluorimetric analysis of camptothecin in Chinese herbal medicine common Camptotheca fruit]. Yao Xue Xue Bao. 2012;47:1370-4 pubmed
    Three-dimensional (3D) fluorescence spectra and thin layer fluorescence chromatogram of common Camptotheca fruit (CCF) crude drug, camptothecin (CPT) and 10-hydroxycamptothecin (HCPT) have been studied, and a novel fluorimetric method ..
  32. Ding T, Jiang T, Zhou J, Xu L, Gao Z. Evaluation of antimicrobial activity of endophytic fungi from Camptotheca acuminata (Nyssaceae). Genet Mol Res. 2010;9:2104-12 pubmed publisher
    ..We isolated 26 endophytic fungi from the leaves, stems and fruits of "the tree of life", Camptotheca acuminata, and tested them for antimicrobial activities based on growth inhibition measurements in a modified ..
  33. Zhu W, Zhao L, Zhao G, Duan X, Qin S, Li J, et al. Plantactinospora endophytica sp. nov., an actinomycete isolated from Camptotheca acuminata Decne., reclassification of Actinaurispora siamensis as Plantactinospora siamensis comb. nov. and emended descriptions of the genus Plantactinospora and Planta. Int J Syst Evol Microbiol. 2012;62:2435-42 pubmed publisher
    A novel endophytic actinomycete, designated strain YIM 68255(T), was isolated from healthy leaves of Camptotheca acuminata Decne. collected in Yunnan province, south-west China and characterized by using a polyphasic approach...
  34. Lin T, Wang G, Lin X, Hu Z, Chen Q, Xu Y, et al. Three new oblongolides from Phomopsis sp. XZ-01, an endophytic fungus from Camptotheca acuminate. Molecules. 2011;16:3351-9 pubmed publisher
    ..XZ-01 of Camptotheca acuminate...
  35. Guo Q, Yuan Q. A novel 10-hydroxycamptothecin-glucoside from the fruit of Camptotheca acuminata. Nat Prod Res. 2016;30:1053-9 pubmed publisher
    Glycosides were isolated from the fruit of Camptotheca acuminata and identified using NMR, MS, UV and IR spectrometries. 10-O-(1-?-D-glycosyl) camptothecin (1) was identified for the first time in a natural material...
  36. Yu P, Xia L, Zhao J, Zhang G, Zhang Z, Lang M, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35:1295-9 pubmed
    ..Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT...
  37. Zhu W, Zhang J, Qin Y, Xiong Z, Zhang D, Klenk H, et al. Blastococcus endophyticus sp. nov., an actinobacterium isolated from Camptotheca acuminata. Int J Syst Evol Microbiol. 2013;63:3269-73 pubmed publisher
    A novel endophytic actinobacterium, designated strain YIM 68236(T), was isolated from healthy leaves of Camptotheca acuminata. and characterized by using a polyphasic approach. Cells of this strain occurred singly, in pairs or in tetrads...
  38. Pasqua G, Silvestrini A, Monacelli B, Mulinacci N, Menendez P, Botta B. Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne. Plant Physiol Biochem. 2006;44:220-5 pubmed
    The metabolic profile of secondary products in calli and cell suspension cultures of Camptotheca acuminata Decaisne was investigated and compared to that of the leaves and roots taken from the plant...
  39. Li M, Tang W, Zeng F, Lou L, You T. Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. Bioorg Med Chem Lett. 2008;18:6441-3 pubmed publisher
    ..The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed...
  40. Li Q, Zhu Q, Zhang X, Hua C, Deng X, Zhao T, et al. A liquid chromatography-tandem mass spectrometry method for pharmacokinetics and tissue distribution of a camptothecin quaternary derivative in rats. Fitoterapia. 2013;90:57-64 pubmed publisher
    ..12% to 108.2%. The preclinical data obtained using this method is expected to facilitate future clinical investigations of CPT8...
  41. Li S, Zhang Z, Cain A, Wang B, Long M, Taylor J. Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata. J Agric Food Chem. 2005;53:32-7 pubmed
    Leaf spots and root rots are major fungal diseases in Camptotheca acuminata that limit cultivation of the plant for camptothecin (CPT), a promising anticancer and antiviral alkaloid...
  42. Ding X, Liu K, Deng B, Chen W, Li W, Liu F. Isolation and characterization of endophytic fungi from Camptotheca acuminata. World J Microbiol Biotechnol. 2013;29:1831-8 pubmed publisher
    In this study, a total of 161 endophytic fungal isolates from Camptotheca acuminata were obtained and classified to 16 taxa according to morphological and molecular analysis...
  43. Zeng X, Li Y, Wu S, Hao R, Li H, Ni H, et al. New and highly efficient column chromatographic extraction and simple purification of camptothecin from Camptotheca acuminata and Nothapodytes pittosporoides. Phytochem Anal. 2013;24:623-30 pubmed publisher
    ..Camptothecin, a widely used natural anti-cancer drug, is difficult to extract and purify effectively from plants...
  44. Liu W. [Improved camptothecin production by cell lines of Camptotheca acuminata]. Shi Yan Sheng Wu Xue Bao. 2003;36:275-8 pubmed
    The concentration of camptothecin was determined in different tissues of Camptotheca acuminata seedling. The concentrations of camptothecin in new leaves and roots were significantly higher than in other tissues...
  45. Pu X, Qu X, Chen F, Bao J, Zhang G, Luo Y. Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Appl Microbiol Biotechnol. 2013;97:9365-75 pubmed publisher
    Camptothecin (CPT), the third largest anticancer drug, is produced mainly by Camptotheca acuminata and Nothapodytes foetida...
  46. Bastian P, Chavarría Krauser A, Engwer C, Jäger W, Marnach S, Ptashnyk M. Modelling in vitro growth of dense root networks. J Theor Biol. 2008;254:99-109 pubmed publisher
    ..Our results provide further understanding of growth and density distribution of hairy root network and therefore it is a sound base for future applications to describe, e.g., secondary metabolite production...
  47. Gu Q, Song D, Zhang H, Zhu M. [Effects of cu2+ on biosynthesis of camptothecin in cell cultures of Camptotheca acuminata]. Sheng Wu Gong Cheng Xue Bao. 2006;22:624-8 pubmed
    Camptothecin is a strong anti-tumor compound isolated from Camptotheca acuminata. One of the most important way for the production of Camptothecin is by cell cultures of Camptotheca acuminata...
  48. Sun S, Yan X. [Effects of nitrogen forms on camptothecin content and its metabolism-related enzymes activities in Camptotheca acuminata seedlings]. Zhongguo Zhong Yao Za Zhi. 2008;33:1519-23 pubmed
    To investigate the effects of nitrogen forms on the camptothecin (CPT) content, tryptophan synthase (TSB) and tryptophan decarboxylase (TDC) activities in Camptotheca acuminata seedlings.
  49. Li G, Chen N, Zhang Y, Li P, Huang X, Jiang R, et al. Six New Pentacyclic Triterpenoids from the Fruit of Camptotheca acuminata. Chem Biodivers. 2017;14: pubmed publisher
    Six new pentacyclic triterpenoids were isolated from the fruit of Camptotheca acuminata. The chemical structures of the new compounds were elucidated by extensive spectroscopic analysis including HR-ESI-MS, IR, UV, 1D- and 2D-NMR...
  50. Wu Y, Lu C, Qian X, Huang Y, Shen Y. Diversities within genotypes, bioactivity and biosynthetic genes of endophytic actinomycetes isolated from three pharmaceutical plants. Curr Microbiol. 2009;59:475-82 pubmed publisher
    ..and fifty endophytic actinomycetes were isolated from three pharmaceutical plants, Annonaceae squamosal, Camptotheca acuminate and Taxus chinensis. Bioactivity test showed that 72...
  51. Sukhanova A, Grokhovsky S, Ermishov M, Mochalov K, Zhuze A, Oleinikov V, et al. DNA structural alterations induced by bis-netropsins modulate human DNA topoisomerase I cleavage activity and poisoning by camptothecin. Biochem Pharmacol. 2002;64:79-90 pubmed
  52. Zhao Y, Liu D, Liang W, Ye Z. In-vivo pharmacokinetics, tissue distribution and anti-tumour effect of hydroxycamptothecin delivered in oil-in-water submicron emulsions. J Pharm Pharmacol. 2012;64:783-91 pubmed publisher
    ..The aim of this study was to investigate the pharmacokinetics, tissue distribution and anti-tumour effect of hydroxycamptothecin submicron emulsions (HCPT-SEs)...
  53. Wang Q, Pi Y, Hou R, Jiang K, Huang Z, Hsieh M, et al. Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (CaHDR) from Camptotheca acuminata and its functional identification in Escherichia coli. BMB Rep. 2008;41:112-8 pubmed
    ..last catalytic enzyme of the MEP pathway for terpenoid biosynthesis, was isolated from camptothecin-producing Camptotheca acuminata. The full-length cDNA of CaHDR was 1686 bp encoding 459 amino acids...
  54. Shen L, Zheng L, Liu H, Liu R, Zhang K, Lai R. Rhizobium kunmingense sp. nov., isolated from rhizosphere soil of Camptotheca acuminata Decne. J Gen Appl Microbiol. 2010;56:143-9 pubmed
    Strain LXD30(T) was isolated from rhizosphere soil of a plant of the species Camptotheca acuminata Decne which is native to warm, humid stream banks in southern China...
  55. Li S, Wang P, Yuan W. Induced endogenous autotoxicity in Camptotheca. Front Biosci (Elite Ed). 2010;2:1196-210 pubmed
    Are plants always immune to their endogenous toxic secondary metabolites? Without disturbance, fast-growing Camptotheca plants can avoid poison by its endogenous camptothecin (DNA topoisomerase I inhibitor) at more than 10 times higher ..
  56. Hu J, Wang L, Xiang T, Pang J. [Studies on the megasporogenesis and microsporegenesis and the development of the female gametophyte and male gametophyte in Camptotheca acuminate]. Fen Zi Xi Bao Sheng Wu Xue Bao. 2008;41:367-75 pubmed
    The ovarium is hypostasy in Camptotheca acuminate Decne.. It has a locule and an ovule. The ovule is pendulous, anatropous andunitegmic. The ovule of Camptotheca acuminate Decne. is pseudocrassinucellate ovule...
  57. Shi W, Zu Y, Yang L, Zhao C, LI J. [Isolation and purification of 10-hydroxycamptothecin and vincoside-lactam from Camptotheca acuminata seed by polyamide]. Zhongguo Zhong Yao Za Zhi. 2008;33:2486-9 pubmed
    ..technological parameters of the isolation and purification of 10-hydroxycamptothecin and vincoside-lactam from Camptotheca acuminata seed by polyamide...
  58. Valletta A, Trainotti L, Santamaria A, Pasqua G. Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae). BMC Plant Biol. 2010;10:69 pubmed publisher
    b>Camptotheca acuminata is a major natural source of the terpenoid indole alkaloid camptothecin (CPT)...
  59. Pi Y, Liao Z, Chai Y, Zeng H, Wang P, Gong Y, et al. Molecular cloning and characterization of a novel stem-specific gene from Camptotheca acuminata. J Biochem Mol Biol. 2006;39:68-75 pubmed
    ..for the first time the isolation of a new cytochrome P450 cDNA that expressed in a stem-specific manner from Camptotheca acuminata (designated as CaSS), a native medicinal plant species in China, using RACE-PCR...
  60. Xiao X, Antony S, Pommier Y, Cushman M. Total synthesis and biological evaluation of 22-hydroxyacuminatine. J Med Chem. 2006;49:1408-12 pubmed
    A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported...
  61. Jiang M, Huang R, Wu Y, Zhou F, Su Q, Wei A. [The study of dynamic acccumulation of camptothecin in Camptotheca acuminata fruit by TLCS]. Zhong Yao Cai. 2008;31:684-6 pubmed
    To establish TLC scanning method for the determination of camptothecin in Camptotheca acuminata fruit, and analysis the dynamic accumulation of camptothecin in Camptotheca acuminata fruit to find out the best collection period.
  62. Sun S, Yan X. [Effect of nitrogen on camptothecin content in Camptotheca acuminata seedlings]. Zhongguo Zhong Yao Za Zhi. 2008;33:356-9 pubmed
    To investigate the effects of nitrogen concentration on the camptothecin (CPT) content in Camptotheca acuminata seedlings:
  63. Pi Y, Jiang K, Hou R, Gong Y, Lin J, Sun X, et al. Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments. Biocell. 2010;34:139-43 pubmed
    ..tissues including roots, stems, leaves, young flower buds, opening flowers, fading flowers and seeds from Camptotheca acuminata, were investigated. The young flower buds had the highest alkaloid concentrations (camptothecin, 2...
  64. Anderson R, Raolji G, Kanazawa A, Greene A. A novel, expeditious synthesis of racemic camptothecin. Org Lett. 2005;7:2989-91 pubmed
    ..Key steps include a Claisen rearrangement of a functionalized allylic ether, a hindered Heck coupling, and a Friedländer condensation...
  65. Montoro P, Maldini M, Piacente S, Macchia M, Pizza C. Metabolite fingerprinting of Camptotheca acuminata and the HPLC-ESI-MS/MS analysis of camptothecin and related alkaloids. J Pharm Biomed Anal. 2010;51:405-15 pubmed publisher
    The major phytochemical constituents, namely, alkaloids, flavonoids and ellagic acid derivatives, of leaves of Camptotheca acuminata were identified using high performance liquid chromatography (HPLC) coupled with electrospray mass ..
  66. Lin J, Liu X, Bao Y, Hou S, An L, Lin X. Effects of isocamptothecin, a novel camptothecin analogue, on proliferation, apoptosis and telomerase activity in HaCaT cells. Exp Dermatol. 2008;17:530-6 pubmed publisher
    ..These results indicate that isocamptothecin possesses similar effects on keratinocytes with camptothecin, but shows far less cytotoxicity, it may probably become a promising agent for psoriasis therapy...
  67. Li W, Yan Z, Shi K. [Experimental study on the viricidal effect of rough extracts of camptothecine fruit on herpes simplex virus-2 in vitro]. Hunan Yi Ke Da Xue Xue Bao. 2002;27:121-2 pubmed
    ..To study the viricidal effect of rough extracts of camptothecine fruit on herpes simplex virus-2 (HSV-2)...
  68. Liu Y, Hu Z, Lin X, Lu C, Shen Y. A new polyketide from Diaporthe sp. SXZ-19, an endophytic fungal strain of Camptotheca acuminate. Nat Prod Res. 2013;27:2100-4 pubmed publisher
    ..SXZ-19 of Camptotheca acuminate...