nuphar

Summary

Summary: A plant genus of the family NYMPHAEACEAE. Members contain sesquiterpene thioalkaloids.

Top Publications

  1. Yoo M, Chanderbali A, Altman N, Soltis P, Soltis D. Evolutionary trends in the floral transcriptome: insights from one of the basalmost angiosperms, the water lily Nuphar advena (Nymphaeaceae). Plant J. 2010;64:687-98 pubmed publisher
    ..Here, we explore the floral transcriptome of the basal angiosperm, Nuphar advena (water lily), for insights into the ancestral developmental program of flowers...
  2. Yin C, Richter U, Börner T, Weihe A. Evolution of plant phage-type RNA polymerases: the genome of the basal angiosperm Nuphar advena encodes two mitochondrial and one plastid phage-type RNA polymerases. BMC Evol Biol. 2010;10:379 pubmed publisher
    ..RpoT polymerases in the plant kingdom and to get more insight into the potential importance of having more than one phage-type RNA polymerase (RNAP) available, we searched for the respective genes in the basal angiosperm Nuphar advena.
  3. Goodenough K, Moran W, Raubo P, Harrity J. Development of a flexible approach to Nuphar alkaloids via two enantiospecific piperidine-forming reactions. J Org Chem. 2005;70:207-13 pubmed
    ..7 via two enantiospecific piperidine-forming techniques and its employment in a general synthetic approach to Nuphar alkaloids...
  4. Moran W, Goodenough K, Raubo P, Harrity J. A concise asymmetric route to Nuphar alkaloids. A formal synthesis of (-)-deoxynupharidine. Org Lett. 2003;5:3427-9 pubmed
    reaction: see text] A stereocontrolled route to Nuphar alkaloids is described that employs a formal [3 + 3] cycloaddition strategy to assemble the piperidine nucleus...
  5. Raubeson L, Peery R, Chumley T, Dziubek C, Fourcade H, Boore J, et al. Comparative chloroplast genomics: analyses including new sequences from the angiosperms Nuphar advena and Ranunculus macranthus. BMC Genomics. 2007;8:174 pubmed
    ..within angiosperms, to include representatives from basally diverging lineages such as the genomes reported here: Nuphar advena (from a basal-most lineage) and Ranunculus macranthus (a basal eudicot)...
  6. Williams J, Edwards J, Ramsey A. Economy, efficiency, and the evolution of pollen tube growth rates. Am J Bot. 2016;103:471-83 pubmed publisher
    ..scaling of wall production rate (WPR) to PTGR in three water lilies that flower concurrently: Nymphaea odorata, Nuphar advena and Brasenia schreberi...
  7. Kujawska M, Klepacki P, Łuczaj Ł. Fischer's Plants in folk beliefs and customs: a previously unknown contribution to the ethnobotany of the Polish-Lithuanian-Belarusian borderland. J Ethnobiol Ethnomed. 2017;13:20 pubmed publisher
    ..Prunella vulgaris, and Nuphar lutea or Lilium sp. The most salient use categories were medicinal, followed by food and home garden plants...
  8. Jain S, Jacob M, Walker L, Tekwani B. Screening North American plant extracts in vitro against Trypanosoma brucei for discovery of new antitrypanosomal drug leads. BMC Complement Altern Med. 2016;16:131 pubmed publisher
    ..Hoita macrostachya, Sabal minor, Syzygium aqueum, Hamamelis virginiana, Coccoloba pubescens, Rhus integrifolia and Nuphar luteum were identified as highly potent antitrypanosomal extracts with IC50 values <1 ?g/mL...
  9. Hein A, Polsakiewicz M, Knoop V. Frequent chloroplast RNA editing in early-branching flowering plants: pilot studies on angiosperm-wide coexistence of editing sites and their nuclear specificity factors. BMC Evol Biol. 2016;16:23 pubmed publisher
    ..angiosperm genera like Amborella, Calycanthus, Ceratophyllum, Chloranthus, Illicium, Liriodendron, Magnolia, Nuphar and Zingiber...

More Information

Publications32

  1. Raghavan S, Rajendar S. Stereoselective total synthesis of (-)-nupharamine utilizing an α-chlorosulfide and a sulfinimine for C-C bond formation. Org Biomol Chem. 2016;14:131-7 pubmed publisher
    An efficient stereoselective synthesis of the nuphar alkaloid, (-)-nupharamine, is reported...
  2. Korotkov A, Li H, Chapman C, Xue H, Macmillan J, Eastman A, et al. Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids. Angew Chem Int Ed Engl. 2015;54:10604-7 pubmed publisher
    Herein, we describe the first total syntheses of five members of the dimeric nuphar alkaloids: (+)-6,6'-dihydroxythiobinupharidine (+)-1 a, (+)-6-hydroxythiobinupharidine (+)-1 b, (-)-6,6'-dihydroxythionuphlutine (-)-2â€..
  3. Shiga T, Yokogawa M, Kaneko S, Isagi Y. Genetic diversity and population structure of Nuphar submersa (Nymphaeaceae), a critically endangered aquatic plant endemic to Japan, and implications for its conservation. J Plant Res. 2017;130:83-93 pubmed publisher
    b>Nuphar submersa (Nymphaeaceae) is a critically endangered freshwater macrophyte indigenous to central Japan, with only four small extant populations represented across its entire range...
  4. Lu P, Herrmann A, Zakarian A. Toward the Synthesis of Nuphar Sesquiterpene Thioalkaloids: Stereodivergent Rhodium-Catalyzed Synthesis of the Thiolane Subunit. J Org Chem. 2015;80:7581-9 pubmed publisher
    A stereodivergent approach to the central thiolane subunit of Nuphar sesquiterpene thioalkaloids has been developed. This approach features a rhodium-catalyzed Stevens-type rearrangement in conjunction with an enzyme resolution reaction...
  5. Yildirim A, Karakaş F, Turker A. In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey. Asian Pac J Trop Med. 2013;6:616-24 pubmed publisher
    ..astracanicum) Jacq., Nepeta nuda (N. nuda) L., Stachys annua (S. annua) L., Genista lydia (G. lydia) Boiss., Nuphar lutea (N. lutea) L., Nymphaea alba (N. alba) L., Vinca minor (V. minor) L., Stellaria media (S. media) L...
  6. Ivanova A, Philippov D, Kulichevskaya I, Dedysh S. Distinct diversity patterns of Planctomycetes associated with the freshwater macrophyte Nuphar lutea (L.) Smith. Antonie Van Leeuwenhoek. 2018;111:811-823 pubmed publisher
    ..The specific focus was made on planctomycetes associated with Nuphar lutea (L.) Smith, an emergent macrophyte with floating leaves, which is widespread in the Holarctic...
  7. Li H, Korotkov A, Chapman C, Eastman A, Wu J. Enantioselective Formal Syntheses of 11 Nuphar Alkaloids and Discovery of Potent Apoptotic Monomeric Analogues. Angew Chem Int Ed Engl. 2016;55:3509-13 pubmed publisher
    Concise, scalable, and enantioselective formal syntheses of eight dimeric and three monomeric nuphar alkaloids were achieved, along with the construction of a stereochemically diverse collection of the first known monomeric analogues ..
  8. Michael J. Simple Indolizidine and Quinolizidine Alkaloids. Alkaloids Chem Biol. 2016;75:1-498 pubmed publisher
    ..analogs), ficuseptine, lasubines, and other simple quinolizidines of the Lythraceae, the simple furyl-substituted Nuphar alkaloids, and a mixed quinolizidine-quinazoline alkaloid...
  9. Ozer L, El On J, Golan Goldhirsh A, Gopas J. Leishmania major: anti-leishmanial activity of Nuphar lutea extract mediated by the activation of transcription factor NF-?B. Exp Parasitol. 2010;126:510-6 pubmed publisher
    Here we report the effect of a partially purified alkaloid fraction (NUP) of Nuphar lutea on nuclear factor kappa B (NF-?B) expression and studied its mechanism of toxicity against Leishmania major in C3H mice peritoneal macrophages...
  10. Chanderbali A, Yoo M, Zahn L, Brockington S, Wall P, Gitzendanner M, et al. Conservation and canalization of gene expression during angiosperm diversification accompany the origin and evolution of the flower. Proc Natl Acad Sci U S A. 2010;107:22570-5 pubmed publisher
    ..However, male gymnosperm cones share genetic features with both perianth (sterile attractive and protective) organs and stamens, supporting the evolutionary origin of the floral perianth from the male genetic program of seed plants...
  11. el On J, Ozer L, Gopas J, Sneir R, Enav H, Luft N, et al. Antileishmanial activity in Israeli plants. Ann Trop Med Parasitol. 2009;103:297-306 pubmed publisher
    ..Of the 41 extracts examined, those of two plants (Nuphar lutea>Withania somnifera) were highly effective (with a maximum inhibitory effect of >50%), those of three ..
  12. Nurminen L, Horppila J. Life form dependent impacts of macrophyte vegetation on the ratio of resuspended nutrients. Water Res. 2009;43:3217-26 pubmed publisher
    ..The floating-leaved Nuphar lutea had a reductive effect on P resuspension but no significant effect on N resuspension...
  13. Snir A, Gurevitz M, Marcus Y. Alterations in Rubisco activity and in stomatal behavior induce a daily rhythm in photosynthesis of aerial leaves in the amphibious-plant Nuphar lutea. Photosynth Res. 2006;90:233-42 pubmed
    b>Nuphar lutea is an amphibious plant with submerged and aerial foliage, which raises the question how do both leaf types perform photosynthetically in two different environments...
  14. Lefebvre D, Kelly D, Budd K. Biotransformation of Hg(II) by cyanobacteria. Appl Environ Microbiol. 2007;73:243-9 pubmed
    ..Furthermore, the efficiency of conversion into beta-HgS by cyanobacteria may lead to the development of applications in the bioremediation of mercury...
  15. Johnson L. Gitksan medicinal plants--cultural choice and efficacy. J Ethnobiol Ethnomed. 2006;2:29 pubmed
    ..I examine use of medicinal plants from a "biobehavioral" perspective to illuminate cultural selection of plants used for medicine by the Gitksan of northwestern British Columbia, Canada...
  16. Matsuda H, Yoshida K, Miyagawa K, Nemoto Y, Asao Y, Yoshikawa M. Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity. Bioorg Med Chem Lett. 2006;16:1567-73 pubmed
    The methanolic extract and its alkaloid fraction from the rhizomes of Nuphar pumilum showed cytotoxic effects on human leukemia cell (U937), mouse melanoma cell (B16F10), and human fibroblast (HT1080)...
  17. Sebesvari Z, Ettwig K, Emons H. Biomonitoring of tin and arsenic in different compartments of a limnic ecosystem with emphasis on Corbicula fluminea and Dikerogammarus villosus. J Environ Monit. 2005;7:203-7 pubmed
    Asian clam Corbicula fluminea, the amphipod Dikerogammarus villosus and the macrophyte Nuphar lutea were tested for investigating spatial and temporal variability in the bioavailability of tin and arsenic in the River Lippe, Germany...
  18. Ozer J, Eisner N, Ostrozhenkova E, Bacher A, Eisenreich W, Benharroch D, et al. Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide. Cancer Biol Ther. 2009;8:1860-8 pubmed
    ..Strong inhibition of NFkappaB activity was found in extracts of leaf and rhizome from Nuphar lutea L. SM. (Nuphar)...
  19. el On J, Ozer L, Gopas J, Sneir R, Golan Goldhirsh A. Nuphar lutea: in vitro anti-leishmanial activity against Leishmania major promastigotes and amastigotes. Phytomedicine. 2009;16:788-92 pubmed publisher
    ..Several anti-leishmanial drugs of choice are of plant origin. Many of the available drugs against the disease are toxic and in certain cases parasite drug resistance is developed. The development of new compounds is urgently required...
  20. Wahl M. Ecological modulation of environmental stress: interactions between ultraviolet radiation, epibiotic snail embryos, plants and herbivores. J Anim Ecol. 2008;77:549-57 pubmed publisher
    ..g. Nuphar lutea) is related to the prevalence of the leaf-mining beetle Galerucella nymphaeae. 2...
  21. Golubev A, Sikorskiĭ V, Kalinin V, Afonin V, Chekan G. [The radioactive contamination dynamics of water body ecosystems of different types in the Chernobyl atomic station alienation zone in Belarus]. Radiats Biol Radioecol. 2007;47:322-32 pubmed
  22. Goulet R, Lalonde J, Munger C, Dupuis S, Dumont Frenette G, Prémont S, et al. Phytoremediation of effluents from aluminum smelters: a study of Al retention in mesocosms containing aquatic plants. Water Res. 2005;39:2291-300 pubmed
    ..the study were to measure the bioaccumulation of dissolved Al by the aquatic plants Typha latifolia, Lemna minor, Nuphar variegatum and Potamogeton epihydrus, and to evaluate their importance in the retention of Al by the mesocosms...
  23. Matsuda H, Morikawa T, Oda M, Asao Y, Yoshikawa M. Potent anti-metastatic activity of dimeric sesquiterpene thioalkaloids from the rhizome of Nuphar pumilum. Bioorg Med Chem Lett. 2003;13:4445-9 pubmed
    The methanolic extract and its alkaloid fraction from the rhizomes of Nuphar pumilum inhibited invasion of B16 melanoma cells across collagen-coated filters in vitro...