myristica fragrans

Summary

Summary: A plant species in the MYRISTICACEAE family. The seed is used as a spice and used for antimicrobial and psychoactive effects. Myristicin, SAFROLE, and methyleugenol are key components.

Top Publications

  1. Grover J, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24:675-80 pubmed
    ..Thus, overall extracts of nutmeg showed a good antidiarrheal effect, with a significant sedative property. The extracts possessed only a weak analgesic effect, with no harmful effects on blood pressure and ECG...
  2. Parle M, Dhingra D, Kulkarni S. Improvement of mouse memory by Myristica fragrans seeds. J Med Food. 2004;7:157-61 pubmed
    ..The present study was undertaken to investigate the effect of Myristica fragrans (MF) seeds on learning and memory in mice...
  3. Sonavane G, Sarveiya V, Kasture V, Kasture S. Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav. 2002;71:239-44 pubmed
    In the present study, the n-hexane extract of Myristica fragrans (MF) seeds, acetone-insoluble part of the n-hexane extract (AIMF) and trimyristin (TM) were assessed for their anxiogenic activity...
  4. Wang Y, Yang X, Tao H, Liu H. [GC-MS analysis of essential oils from seeds of Myristica fragrans in Chinese market]. Zhongguo Zhong Yao Za Zhi. 2004;29:339-42 pubmed
    To analyze the constituents of the essential oils extracted from nine samples of commercial seeds of Myristica fragrans Houtt respectively and to provide qualities control foundations.
  5. Qiu Q, Zhang G, Sun X, Liu X. [Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation]. Zhong Yao Cai. 2004;27:823-6 pubmed
    Essential oils were extracted from Myristica fragrans Houtt. by supercritical fluid extraction (SFE) and steam distillation (SD). Their components were analyzed by gas chromatography-mass spectrometry and compared...
  6. Dhingra D, Sharma A. Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. J Med Food. 2006;9:84-9 pubmed
    The present study was undertaken to investigate the effect of an n-hexane extract of Myristica fragrans seeds on depression in mice by using the forced swim test (FST) and the tail suspension test (TST). M...
  7. Beyer J, Ehlers D, Maurer H. Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther Drug Monit. 2006;28:568-75 pubmed
  8. Anggakusuma -, Yanti -, Hwang J. Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells. J Dermatol Sci. 2010;57:114-22 pubmed publisher
  9. Morita T, Jinno K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, et al. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury. J Agric Food Chem. 2003;51:1560-5 pubmed
    ..However, further studies are needed to elucidate the hepatoprotective mechanism(s) of myristicin...

More Information

Publications84

  1. Tajuddin -, Ahmad S, Latif A, Qasmi I. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med. 2003;3:6 pubmed
    ..In order to explore the sexual function improving effect of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry...
  2. Wahab A, Ul Haq R, Ahmed A, Khan R, Raza M. Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytother Res. 2009;23:153-8 pubmed publisher
    ..study was to investigate the anticonvulsant activity of the volatile oil of nutmeg, the dried seed kernel of Myristica fragrans Houtt, using well-established animal seizure models and to evaluate its potential for acute toxicity and ..
  3. Sharma M, Kumar M. Radioprotection of Swiss albino mice by Myristica fragrans houtt. J Radiat Res. 2007;48:135-41 pubmed
    Nutmeg, the dried seed kernel of Myristica fragrans, MF (Family: Myristicaceae) possesses antifungal, hepatoprotective and antioxidant properties...
  4. Tajuddin -, Ahmad S, Latif A, Qasmi I, Amin K. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med. 2005;5:16 pubmed
    b>Myristica fragrans Houtt. (nutmeg) has been mentioned in Unani medicine to be of value in the management of male sexual disorders...
  5. Narasimhan B, Dhake A. Antibacterial principles from Myristica fragrans seeds. J Med Food. 2006;9:395-9 pubmed
    Nutmeg (Myristica fragrans) is used in food preparations for its aromatic flavor. The present investigation was undertaken to evaluate the antibacterial activity of constituents of M. fragrans seeds. Seeds of M...
  6. Checker R, Chatterjee S, Sharma D, Gupta S, Variyar P, Sharma A, et al. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol. 2008;8:661-9 pubmed publisher
    Recently, the lignans present in the aqueous extract of fresh nutmeg mace (aril of the fruit of Myristica fragrans) were shown to possess antioxidant properties in cell free systems and protected PUC18 plasmid against radiation-induced ..
  7. Chirathaworn C, Kongcharoensuntorn W, Dechdoungchan T, Lowanitchapat A, Sa nguanmoo P, Poovorawan Y. Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J Med Assoc Thai. 2007;90:2422-8 pubmed
    b>Myristica fragrans Houtt. (nutmeg) contains antibacterial, antiviral and anti-cancer activities. However the mechanisms underlying those activities have not been clearly explained.
  8. Yang X, Huang X, Ahmat M. [New neolignan from seed of Myristica fragrans]. Zhongguo Zhong Yao Za Zhi. 2008;33:397-402 pubmed
    To study the chemical constituents in the nutmeg (seed of Myristica fragrans).
  9. Cho J, Choi G, Son S, Jang K, Lim H, Lee S, et al. Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi. Pest Manag Sci. 2007;63:935-40 pubmed
    ..vivo antifungal activity against various plant diseases, we found that treatment with a methanol extract of Myristica fragrans Houttyn (nutmeg) seeds reduced the development of various plant diseases...
  10. Chung J, Choo J, Lee M, Hwang J. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine. 2006;13:261-6 pubmed
    ..Preliminary antibacterial screening revealed that the extract of Myristica fragrans, widely cultivated for the spice and flavor of foods, possessed strong inhibitory activity against S. mutans...
  11. Cho Y, Kim K, Shim J, Hwang J. Inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanin biosynthesis. Biol Pharm Bull. 2008;31:986-9 pubmed
    The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT...
  12. Dhingra D, Parle M, Kulkarni S. Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice. J Med Food. 2006;9:281-3 pubmed
    ..was undertaken to estimate the acetylcholinesterase- inhibiting activity of extracts of Glycyrrhiza glabra, Myristica fragrans seeds, and ascorbic acid and compare these values with a standard acetylcholinesterase-inhibiting drug, ..
  13. Yang S, Na M, Jang J, Kim K, Kim B, Sung N, et al. Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans. Phytother Res. 2006;20:680-2 pubmed
    ..Bioassay-guided fractionation of a MeOH extract of the semen of Myristica fragrans Houtt...
  14. Piras A, Rosa A, Marongiu B, Atzeri A, Dessi M, Falconieri D, et al. Extraction and separation of volatile and fixed oils from seeds of Myristica fragrans by supercritical CO?: chemical composition and cytotoxic activity on Caco-2 cancer cells. J Food Sci. 2012;77:C448-53 pubmed publisher
    ..Moreover, the essential oil obtained from nutmeg, as well as myristicin, showed a significant in vitro inhibitory effect on the growth of a colon cancer cell line (undifferentiated Caco-2 cells)...
  15. Yang X, Huang X, Ma L, Wu Q, Xu W. The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model. Planta Med. 2010;76:1587-91 pubmed publisher
    The intestinal permeability and transport of 10 neolignans isolated from MYRISTICA FRAGRANS were studied by using the Caco-2 cell monolayer model. The 10 neolignans were measured by HPLC...
  16. Rukayadi Y, Kim K, Hwang J. In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. Phytother Res. 2008;22:308-12 pubmed
    ..The study aimed to determine the efficacy of macelignan, isolated from nutmeg (Myristica fragrans Houtt.), in removing each single oral primary biofilm in vitro on a polystyrene 96-well microtiter plate...
  17. Takino M, Tanaka T, Yamaguchi K, Nakahara T. Atmospheric pressure photo-ionization liquid chromatography/mass spectrometric determination of aflatoxins in food. Food Addit Contam. 2004;21:76-84 pubmed
    ..3-5.1%. The limit of detection (S/N = 3) in all food was in the range 0.11-0.5 ng g(-1). From these studies, it is suggested that APPI can be used as an additional tool in food residue analysis. ..
  18. Patil S, Ghadyale V, Taklikar S, Kulkarni C, Arvindekar A. Insulin secretagogue, alpha-glucosidase and antioxidant activity of some selected spices in streptozotocin-induced diabetic rats. Plant Foods Hum Nutr. 2011;66:85-90 pubmed publisher
    ..b>Myristica fragrans, Parmelia perlata, Illicium verum, Trachyspermum copticum and Myristica malabarica, the commonly used spices ..
  19. Breidbach A, Ulberth F. Comparative evaluation of methods for the detection of 2-alkylcyclobutanones as indicators for irradiation treatment of cashew nuts and nutmeg. Food Chem. 2016;201:52-8 pubmed publisher
    ..None of the 26 cashew nut and 14 nutmeg samples purchased in different EU Member States contained traces of 2-alkylcyclobutanones. ..
  20. Ananthakumar A, Variyar P, Sharma A. Estimation of aroma glycosides of nutmeg and their changes during radiation processing. J Chromatogr A. 2006;1108:252-7 pubmed
    ..A routine method based on extraction into n-butanol and subsequent quantification of post-irradiation changes in aroma glycosides on a TLC plate using a densitometer is proposed. ..
  21. Okano K, Tomita T, Ohzu Y, Takai M, Ose A, Kotsuka A, et al. Aflatoxins B and g contamination and aflatoxigenic fungi in nutmeg. Shokuhin Eiseigaku Zasshi. 2012;53:211-6 pubmed
    ..bombycis based on morphological characters, growth rates at 37°C and 42°C and also molecular-genetic methods. Our results indicate that these two species are mainly responsible for aflatoxin G contamination in nutmeg products. ..
  22. Ma J, Hwang Y, Cho W, Han S, Hwang J, Han J. Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells. Biol Pharm Bull. 2009;32:1085-90 pubmed
    A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells...
  23. Raffo A, D Aloise A, Magrì A, Leclercq C. Quantitation of tr-cinnamaldehyde, safrole and myristicin in cola-flavoured soft drinks to improve the assessment of their dietary exposure. Food Chem Toxicol. 2013;59:626-35 pubmed publisher
    ..The lowest MOE values, from 1900 to 3000, were observed for children and teen agers in the United Kingdom and Ireland. ..
  24. Xiong R, Li W, Li Y, Zheng K, Zhang T, Gao M, et al. Er Shen Wan extract reduces diarrhea and regulates AQP 4 and NHE 3 in a rat model of spleen-kidney Yang deficiency-induced diarrhea. Biomed Pharmacother. 2018;98:834-846 pubmed publisher
    ..and Myristicae Semen (Nutmeg, from Myristica fragrans Houtt.), is widely used to treat spleen-kidney Yang deficiency (SKYD)-induced diarrhea...
  25. Pandey R, Mahar R, Hasanain M, Shukla S, Sarkar J, Rameshkumar K, et al. Rapid screening and quantitative determination of bioactive compounds from fruit extracts of Myristica species and their in vitro antiproliferative activity. Food Chem. 2016;211:483-93 pubmed publisher
    ..Myristica beddomeii, Myristica fragrans, Myristica fatua and Myristica malabarica...
  26. Balakrishnan S, Sivaji I, Kandasamy S, Duraisamy S, Kumar N, Gurusubramanian G. Biosynthesis of silver nanoparticles using Myristica fragrans seed (nutmeg) extract and its antibacterial activity against multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates. Environ Sci Pollut Res Int. 2017;24:14758-14769 pubmed publisher
    ..In the present study, silver nanoparticles (AgNPs) from aqueous seed extract of Myristica fragrans (nutmeg) were characterized...
  27. Li F, Yang X. Biotransformation of myrislignan by rat liver microsomes in vitro. Phytochemistry. 2008;69:765-71 pubmed
    ..propan-1-ol, is a major acyclic neolignan in seeds of Myristica fragrans. Studies have suggested that myrislignan may deter feeding activity, but little is known about its ..
  28. Martinez Sena M, de la Guardia M, Esteve Turrillas F, Armenta S. Hard cap espresso extraction and liquid chromatography determination of bioactive compounds in vegetables and spices. Food Chem. 2017;237:75-82 pubmed publisher
    ..Hard cap espresso machines offer a fast, effective and quantitative tool for the extraction of bioactive compounds from food samples with an extraction time lower than 30s, using a global available and low cost equipment. ..
  29. McKenna A, Nordt S, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med. 2004;11:240-1 pubmed
    ..Emergency staff should be aware of the effects of nutmeg, which may present in marijuana users who seek alternative substances. ..
  30. Nurkanto A, Julistiono H. Screening and study of antifungal activity of leaf litter actinomycetes isolated from Ternate Island, Indonesia. Asian Pac J Trop Med. 2014;7S1:S238-43 pubmed publisher
    ..Actinomycetes were isolated from leaf litter of Durio species, Syzygium aromaticum, Piper betle, Myristica fragrans, or Pandanus species and unknown plants. Actinomycetes isolates were cultured in a liquid medium...
  31. Plaingam W, Sangsuthum S, Angkhasirisap W, Tencomnao T. Kaempferia parviflora rhizome extract and Myristica fragrans volatile oil increase the levels of monoamine neurotransmitters and impact the proteomic profiles in the rat hippocampus: Mechanistic insights into their neuroprotective effects. J Tradit Complement Med. 2017;7:538-552 pubmed publisher
    Potentially useful in the treatment of neurodegenerative disorders, Kaempferia parviflora and Myristica fragrans have been shown to possess a wide spectrum of neuropharmacological activities and neuroprotective effects in..
  32. Park J, Hwan Lim S, Ram Kim B, Jae Jeong H, Kwon H, Song G, et al. Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans. Bioorg Med Chem Lett. 2017;27:3060-3064 pubmed publisher
    ..characterization of novel inhibitors of the Streptococcus pneumoniae sialidases NanA, NanB, and NanC from Myristica fragrans seeds...
  33. Sohn J, Han K, Choo J, Hwang J. Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage. Biofactors. 2007;29:1-10 pubmed
    In this study, we investigated the protective effect of macelignan, isolated from Myristica fragrans Houtt. (nutmeg) against tert-butylhydroperoxide (t-BHP)-induced cytotoxicity in a human hepatoma cell line, HepG2...
  34. Han Y, Kim M, Hwang J. Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. Inflammation. 2012;35:1723-31 pubmed publisher
    ..To evaluate the anti-allergic effects of macelignan isolated from Myristica fragrans Houtt...
  35. Li F, Yang X. Metabolism of the lignan dehydrodiisoeugenol in rats. Planta Med. 2011;77:1712-7 pubmed publisher
    Dehydrodiisoeugenol (DDIE), a major active lignan from the seed and aril of the fruit of Myristica fragrans Houtt...
  36. Paul S, Hwang J, Kim H, Jeon W, Chung C, Han J. Multiple biological properties of macelignan and its pharmacological implications. Arch Pharm Res. 2013;36:264-72 pubmed publisher
    Macelignan found in the nutmeg mace of Myristica fragrans obtains increasing attention as a new avenue in treating various diseases...
  37. Dzotam J, Simo I, Bitchagno G, Celik I, Sandjo L, Tane P, et al. In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3',4',7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria. BMC Complement Altern Med. 2018;18:15 pubmed publisher
    Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes...
  38. Zhao R, Wang W, Zhao L, Li Z, Wang J. [Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice]. Zhongguo Zhong Yao Za Zhi. 2009;34:447-9 pubmed
    ..01) and the contents of MDA was reduced significantly (P < 0.01). The volatile oil from nutmeg showed induction effect on the hepatic microsomal CYP in mice. ..
  39. Mukherjee P, Kumar V, Houghton P. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res. 2007;21:1142-5 pubmed
    ..Andrographis paniculata, Centella asiatica, Evalvulus alsinoides, Nardostachys jatamansi, Nelumbo nucifera, Myristica fragrans used in Indian systems of medicine, were tested for in vitro acetylcholinesterase inhibitory activity based ..
  40. Li F, Yang X. Simultaneous determination of diastereomers (+)-licarin A and isolicarin A from Myristica fragrans in rat plasma by HPLC and its application to their pharmacokinetics. Planta Med. 2008;74:880-4 pubmed publisher
    ..05 and 0.25 microg/mL for (+)-licarin A, and 0.05 and 0.10 microg/mL for isolicarin A, respectively. This assay method was successfully applied to study the pharmacokinetics of diastereomers (+)-licarin A and isolicarin A in rat plasma...
  41. Krol C, Janssen M. [Unusual use of nutmeg]. Ned Tijdschr Geneeskd. 2010;154:A2214 pubmed
    ..Symptoms disappear without sequelae after 24-48 h. Treatment consists of supportive measures. In the event of haemodynamic instability, cardiovascular monitoring is indicated...
  42. Zhu Z, Yang S, Zhao W, Li R, Zhao C. A Comparative Pharmacokinetic Study of Myrislignan by UHPLC-MS After Oral Administration of a Monomer and Myristica fragrans Extract to Rats. J Chromatogr Sci. 2016;54:689-96 pubmed publisher
    ..the pharmacokinetic properties of myrislignan after oral administration of the myrislignan monomer and Myristica fragrans extract in rats...
  43. Sein Anand J, Barwina M, Waldman W. [Acute intoxication with nutmeg used as a recreational purpose--a case report]. Przegl Lek. 2013;70:693-4 pubmed
    ..Poisoning had a stormy clinical course with symptoms of gastrointestinal, cardiovascular and nervous system. The widespread availability of nutmeg suggests that real number of these poisonings may be underestimated in our country...
  44. Nguyen P, Le T, Kang H, Chae J, Kim S, Kwon K, et al. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett. 2010;20:4128-31 pubmed publisher
    ..As part of an ongoing search for new AMPK activators from plants, this study found that the total extract of Myristica fragrans (nutmeg) activated the AMPK enzyme in differentiated C2C12 cells...
  45. Piaru S, Mahmud R, Abdul Majid A, Mahmoud Nassar Z. Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Asian Pac J Trop Med. 2012;5:294-8 pubmed publisher
    Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils...
  46. Cuong T, Hung T, Na M, Ha D, Kim J, Lee D, et al. Inhibitory effect on NO production of phenolic compounds from Myristica fragrans. Bioorg Med Chem Lett. 2011;21:6884-7 pubmed publisher
    ..3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry...
  47. Leung E, Tang P, Ye Y, Chan W. Analysis of 2-alkylcyclobutanones in cashew nut, nutmeg, apricot kernel, and pine nut samples: re-evaluating the uniqueness of 2-alkylcyclobutanones for irradiated food identification. J Agric Food Chem. 2013;61:9950-4 pubmed publisher
    ..Thus, 2-DCB and 2-TCB are still valid to be used as biomarkers for identifying irradiated food. ..
  48. Demetriades A, Wallman P, McGuiness A, Gavalas M. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J. 2005;22:223-5 pubmed
  49. Noiles K, Pratt M. Contact dermatitis to Vicks VapoRub. Dermatitis. 2010;21:167-9 pubmed
    ..We present a case of a patient who developed an ACD secondary to application of her VVR...
  50. Duan L, Tao H, Hao X, Gu Q, Zhu W. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans. Planta Med. 2009;75:1241-5 pubmed publisher
    Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (-)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)-phenyl]-1-nonanone ( 1) and (7 R,8 R)-7,8-dihydro-7-(3,..
  51. Sohn J, Han K, Kim J, Rukayadi Y, Hwang J. Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol Pharm Bull. 2008;31:273-7 pubmed
    ..This study investigated the protective effect of macelignan, isolated from Myristica fragrans HOUTT...
  52. Zhang C, Qi X, Shi Y, Sun Y, Li S, Gao X, et al. Estimation of trace elements in mace (Myristica fragrans Houtt) and their effect on uterine cervix cancer induced by methylcholanthrene. Biol Trace Elem Res. 2012;149:431-4 pubmed publisher
    In the present work, trace elemental analysis of mace (Myristica fragrans Houtt) was carried out by the atomic absorption spectrometry technique...
  53. Kelly B, Gavin B, Clarke M, Lane A, Larkin C. Nutmeg and psychosis. Schizophr Res. 2003;60:95-6 pubmed
  54. Akinboro A, Mohamed K, Asmawi M, Othman A, Ying T, Maidin S. Mutagenic and antimutagenic assessment of methanol leaf extract of Myristica fragrans (Houtt.) using in vitro and in vivo genetic assays. Drug Chem Toxicol. 2012;35:412-22 pubmed publisher
    ..This study determined the potential anticancer efficacy of the leaf extract of Myristica fragrans (Houtt.). Methanol leaf extract of M. fragrans (Houtt...
  55. Akinboro A, Mohamed K, Asmawi M, Sulaiman S, Sofiman O. Antioxidants in aqueous extract of Myristica fragrans (Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L. cells. J Zhejiang Univ Sci B. 2011;12:915-22 pubmed publisher
    In this study, freeze-dried water extract from the leaves of Myristica fragrans (Houtt.) was tested for mutagenic and antimutagenic potentials using the Allium cepa assay...
  56. Lee M, Kim K, Kim D, Lee K, Hwang J. meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells. Biol Pharm Bull. 2011;34:1628-30 pubmed
    ..of meso-dihydroguaiaretic acid (MDA), anti-oxidative and anti-inflammatory compound isolated from the Myristica fragrans HOUTT., by oil red O staining, reverse transcription-polymerase chain reaction (RT-PCR), and Western blot...
  57. Muñoz Acuña U, Carcache P, Matthew S, Carcache de Blanco E. New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects. Food Chem. 2016;202:269-75 pubmed publisher
    The bioassay-guided fractionation of the aril of Myristica fragrans (mace spice) yielded five phenolic compounds, one new acyclic bis phenylpropanoid (1) and four previously known phenolic compounds: compounds (1) (S) 1-(3,4,5-..
  58. Forrester M. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol. 2005;24:563-6 pubmed
    ..6 versus 16.7%). The majority of both abuse and non-abuse calls were managed outside of health care facilities (54.5 and 66.7%, respectively). None of the ingestions resulted in more than moderate clinical effects or death...
  59. Li F, Yang X. Determination of dehydrodiisoeugenol in rat tissues using HPLC method. Biomed Chromatogr. 2008;22:1206-12 pubmed publisher
    Dehydrodiisoeugenol (DDIE) is a bioactive neolignan from the seeds of Myristica fragrans Houtt., which exhibits good anti-inflammatory activity...
  60. Maeda A, Tanimoto S, Abe T, Kazama S, Tanizawa H, Nomura M. [Chemical constituents of Myristica fragrans Houttuyn seed and their physiological activities]. Yakugaku Zasshi. 2008;128:129-33 pubmed
    ..High antioxidant activity was found in monoterpenoid extracts including terpinene-4-ol (3), alpha-terpineol (4), and 4-allyl-2,6-dimethoxyphenol (12). Compound, 12 expressed particularly high antioxidant activity...
  61. Smith Palmer A, Stewartt J, Fyfe L. Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils. J Med Microbiol. 2002;51:567-74 pubmed
    ..These changes were observed despite the oils causing no change to the final bacterial concentration or total extracellular protein concentration...
  62. Kang J, Min B, Lee J. Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. Phytother Res. 2013;27:1694-9 pubmed publisher
    ..of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (EATN), a neolignan isolated from Myristica fragrans, using human platelets...
  63. Motilal S, Maharaj R. Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study. J Altern Complement Med. 2013;19:347-52 pubmed publisher
    ..Nutmeg has certain properties that may be effective in ameliorating neuropathic pain. The purpose of this study was to determine whether topical nutmeg extracts can reduce pain or improve the quality of life in PDN sufferers...
  64. Mahady G, Pendland S, Stoia A, Hamill F, Fabricant D, Dietz B, et al. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res. 2005;19:988-91 pubmed
    ..Methanol extracts of Myristica fragrans (seed) had a MIC of 12...
  65. Kwon Y, Kim D, Kim J, Hwang J. Effects of licarin E on expression of matrix metalloproteinase-1 and type-1 procollagen in UVB-irradiated human skin fibroblasts. Phytother Res. 2011;25:1891-4 pubmed publisher
    ..This study evaluated the effects of licarin E isolated from mace, the aril of Myristica fragrans Houtt., on MMP-1 and type-1 procollagen levels in UVB-irradiated human skin fibroblasts...
  66. Carstairs S, Cantrell F. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila). 2011;49:177-80 pubmed publisher
    ..Numerous citations in the medical literature report its abuse as a psychoactive agent, primarily for its purported hallucinogenic effects that are thought to be due to the compound myristicin; these are primarily limited to case reports...
  67. Muchtaridi -, Subarnas A, Apriyantono A, Mustarichie R. Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice. Int J Mol Sci. 2010;11:4771-81 pubmed publisher
    The present study was designed to evaluate the inhibitory effect of nutmeg (Myristica fragrans Houtt.) seed essential oil on the locomotor activity of mice in a wheel cage...
  68. Jung W, Jang Y, Hieu T, Lee C, Ahn Y. Toxicity of Myristica fagrans seed compounds against Blattella germanica (Dictyoptera: Blattellidae). J Med Entomol. 2007;44:524-9 pubmed
    The insecticidal constituents of hexane-soluble fraction from a methanolic extract of the seeds from Myristica fragrans (Myristicaceae) against adult females of Blattella germanica (L...
  69. El Alfy A, Wilson L, ElSohly M, Abourashed E. Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay. J Ethnopharmacol. 2009;126:280-6 pubmed publisher
    ..Nutmeg at high doses is considered a cheap substitute to several drugs of abuse. Earlier reports have attributed amphetamine-like activities to nutmeg...
  70. Firouzi R, Shekarforoush S, Nazer A, Borumand Z, Jooyandeh A. Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken. J Food Prot. 2007;70:2626-30 pubmed
    ..Although examination of spices in culture media can yield accurate microbiological data, without complementary tests in foods these data are of limited value for assessing food safety...
  71. Lee K, Mun S, Pyun H, Kim M, Hwang J. Effects of macelignan isolated from Myristica fragrans (Nutmeg) on expression of matrix metalloproteinase-1 and type I procollagen in UVB-irradiated human skin fibroblasts. Biol Pharm Bull. 2012;35:1669-75 pubmed
    ..Macelignan, a natural lignan compound isolated from Myristica fragrans HOUTT. (nutmeg), has been reported to possess antioxidant and antiinflammatory activities...
  72. Niyas Z, Variyar P, Gholap A, Sharma A. Effect of gamma-irradiation on the lipid profile of nutmeg (Myristica fragrans Houtt.). J Agric Food Chem. 2003;51:6502-4 pubmed
    The effect of gamma-irradiation on the lipid constituents of nutmeg (Myristica fragrans) was examined at radiation doses between 2.5 and 10 kGy...
  73. Yadav A, Bhatnagar D. Modulatory effect of spice extracts on iron-induced lipid peroxidation in rat liver. Biofactors. 2007;29:147-57 pubmed
    ..used in Indian foods such as cloves (Syzygium aromaticum), licorice (Glycyrrhiza glabra), mace (aril of Myristica fragrans) and greater cardamom (Amomum subulatum), were selected as the test samples to find their effect on the ..
  74. Kwon H, Kim M, Jeong H, Yang M, Park K, Jeong T, et al. Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds. Bioorg Med Chem Lett. 2008;18:194-8 pubmed
    Six diarylbutane lignans 1-5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound...
  75. Hang X, Yang X. [GC-MS analysis of essential oil from nutmeg processed by different traditional methods]. Zhongguo Zhong Yao Za Zhi. 2007;32:1669-75 pubmed
    To analyze the chemical components of the essential oil extracted from the seeds of Myristica fragrans (nutmeg) processed by different methods (steamed with water steam, roasted with flour, sauted with flour, roasted with talcum powder, ..