tinospora

Summary

Summary: A plant genus of the family MENISPERMACEAE. Members have been used in AYURVEDIC MEDICINE. Hypoglycemic effect has been reported.

Top Publications

  1. Stanely Mainzen Prince P, Menon V. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res. 2003;17:410-3 pubmed
    ..investigation was undertaken to evaluate the hypoglycaemic and hypolipidaemic effects of an alcohol extract of Tinospora cordifolia roots, an indigenous plant used in Ayurvedic medicine in India...
  2. Li R, Leach D, Myers S, Leach G, Lin G, Brushett D, et al. Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth. Phytother Res. 2004;18:78-83 pubmed
    b>Tinospora smilacina Benth. has been used in Australian indigenous medicine for the treatment of headache, rheumatoid arthritis and other inflammatory disorders...
  3. Ahmed S, Manhas L, Verma V, Khajuria R. Quantitative determination of four constituents of Tinospora sps. by a reversed-phase HPLC-UV-DAD method. Broad-based studies revealing variation in content of four secondary metabolites in the plant from different eco-geographical regions of India. J Chromatogr Sci. 2006;44:504-9 pubmed
    ..markers, such as 20beta-hydroxyecdysone, tinosporaside, cordioside, and columbin, present in three species of Tinospora viz, T. cordifolia, T. malabrica, and T. crispa...
  4. Prince P, Padmanabhan M, Menon V. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Phytother Res. 2004;18:785-7 pubmed
    The present study investigates the effect of oral administration of an alcoholic extract of Tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats...
  5. Thippeswamy G, Sheela M, Salimath B. Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity. Eur J Pharmacol. 2008;588:141-50 pubmed publisher
    ..The present study identified octacosanol isolated from the plant Tinospora cordifolia as a new antiangiogenic compound with inhibitory effects on in vivo angiogenesis assays...
  6. Singh R, Banerjee S, Kumar P, Raveesha K, Rao A. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine. 2006;13:74-84 pubmed
    ..we investigated the effect of a hydroalcoholic (80% ethanol: 20% distilled water) extract of aerial roots of Tinospora cordifolia (50 and 100mg/kg body wt...
  7. Gupta R, Sharma A. Antifertility effect of Tinospora cordifolia (Willd.) stem extract in male rats. Indian J Exp Biol. 2003;41:885-9 pubmed
    ..Serum testosterone levels showed significant reduction after Tinospora extract feeding...
  8. Sangeetha M, Balaji Raghavendran H, Gayathri V, Vasanthi H. Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. J Nat Med. 2011;65:544-50 pubmed publisher
    ..The anti-diabetic efficiency of a medicinal plant, Tinospora cordifolia (TC) was studied in experimentally induced type 2 diabetes in Sprague-Dawley rats...
  9. Reddy S, Ramatholisamma P, Ramesh B, Baskar R, Saralakumari D. Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in Wistar rats. Horm Metab Res. 2009;41:741-6 pubmed
    ..The present study was designed to investigate the eff ect of the aqueous extract of Tinospora cordifolia stem (TCAE) on the adverse eff ects of fructose loading toward carbohydrate and lipid metabolism in ..

More Information

Publications76

  1. Purandare H, Supe A. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study. Indian J Med Sci. 2007;61:347-55 pubmed
    ..We evaluated the role of generalized immunomodulation in diabetic ulcers by using Tinospora cordifolia as an adjuvant therapy and studied its influence on parameters/determinants of healing, on bacterial ..
  2. Singh L, Tyagi S, Rizvi M, Goel H. Effect of Tinospora cordifolia on gamma ray-induced perturbations in macrophages and splenocytes. J Radiat Res. 2007;48:305-15 pubmed
    b>Tinospora cordifolia (RTc) has already been reported to protect whole-body lethally irradiated mice. This study has focussed on certain aspects of immuno-competence, which are adversely affected by irradiation...
  3. Sudhakaran D, Srirekha P, Devasree L, Premsingh S, Michael R. Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus. Indian J Exp Biol. 2006;44:726-32 pubmed
    ..hydrophila. The results indicates the potential of T. cordifolia leaf extracts for use as an immunoprophylactic to prevent diseases in finfish aquaculture. ..
  4. Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol Sci. 2002;27:139-46 pubmed
    Effect of Tinospora cordifolia extract on modulation of hepatoprotective and immunostimulatory functions in carbon tetrachloride (CCl4) intoxicated mature rats is reported here. Administration of CCl4 (0...
  5. Alexander C, Kirubakaran C, Michael R. Water soluble fraction of Tinospora cordifolia leaves enhanced the non-specific immune mechanisms and disease resistance in Oreochromis mossambicus. Fish Shellfish Immunol. 2010;29:765-72 pubmed publisher
    The present paper describes the effect of water-soluble fraction of the leaves of the Indian medicinal plant, Tinospora cordifolia (Miers) on the non-specific immunity and disease resistance in Oreochromis mossambicus (Peters)...
  6. Nair P, Melnick S, Ramachandran R, Escalon E, Ramachandran C. Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia. Int Immunopharmacol. 2006;6:1815-24 pubmed
    The signaling mechanism of the novel (1,4)-alpha-D-glucan (RR1) isolated from the medicinal plant Tinospora cordifolia was investigated in macrophages to evaluate its immunostimulating properties. When RAW264...
  7. Agrawal S, Naqvi S, Gupta S, Srivastava S. Prevention and management of diabetic retinopathy in STZ diabetic rats by Tinospora cordifolia and its molecular mechanisms. Food Chem Toxicol. 2012;50:3126-32 pubmed publisher
    We investigated the potential of Tinospora cordifolia (TC) in treatment of diabetic retinopathy in STZ-induced rats due to its antihyperglycemic, angiogenic, antiinflammatory and antioxidant effects...
  8. Rungruang T, Boonmars T. In vivo antiparasitic activity of the Thai traditional medicine plant--Tinospora crispa--against Plasmodium yoelii. Southeast Asian J Trop Med Public Health. 2009;40:898-900 pubmed
    We investigated the in vivo antimalarial effect of crude extract of Tinospora crispa, a Thai traditional medicine plant...
  9. Kapur P, Jarry H, Wuttke W, Pereira B, Seidlova Wuttke D. Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats. Maturitas. 2008;59:329-38 pubmed publisher
    ..The available courses of therapy to osteoporosis in menopausal women are limited by several side effects generated. A need therefore arises to explore herbal alternatives that are effective and safe...
  10. Rawal A, Muddeshwar M, Biswas S. Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochem Biophys Res Commun. 2004;324:588-96 pubmed
    ..Rubia cordifolia (RC), Fagonia cretica linn (FC), and Tinospora cordifolia (TC) have been reported to contain a wide variety of antioxidants and have been in use in the eastern ..
  11. Badar V, Thawani V, Wakode P, Shrivastava M, Gharpure K, Hingorani L, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol. 2005;96:445-9 pubmed
    The efficacy of Tinospora cordifolia (TC) extract in patients of allergic rhinitis was assessed in a randomized double blind placebo controlled trial. Seventy-five patients were randomly given either TC or placebo for 8 weeks...
  12. Jahfar M. Glycosyl composition of polysaccharide from Tinospora cordifolia. Acta Pharm. 2003;53:65-9 pubmed
    Polysaccharide from Tinospora cordifolia was isolated, purified, hydrolysed, trimethylsilylated and then subjected to GC-MC studies. The polysaccharide composition was estimated as follows: glucose 98.0%, arabinose 0.5%, rhamnose 0...
  13. Mukherjee R, De U, Ram G. Evaluation of mammary gland immunity and therapeutic potential of Tinospora cordifolia against bovine subclinical mastitis. Trop Anim Health Prod. 2010;42:645-51 pubmed publisher
    Enhancement of the diseased mammary gland immunity and therapeutic potential of hydro-methanolic extract of Tinospora cordifolia (T. cordifolia; stem) in bovine subclinical mastitis was investigated...
  14. Chaudhary R, Jahan S, Goyal P. Chemopreventive potential of an Indian medicinal plant (Tinospora cordifolia) on skin carcinogenesis in mice. J Environ Pathol Toxicol Oncol. 2008;27:233-43 pubmed
    b>Tinospora cordifolia (Guduchi), an Indian medicinal plant, was used to explore antitumor promoting activity in a two-stage skin carcinogenesis model...
  15. Gowrishankar R, Kumar M, Menon V, Divi S, Saravanan M, Magudapathy P, et al. Trace Element Studies on Tinospora cordifolia (Menispermaceae), Ocimum sanctum (Lamiaceae), Moringa oleifera (Moringaceae), and Phyllanthus niruri (Euphorbiaceae) Using PIXE. Biol Trace Elem Res. 2010;133:357-63 pubmed publisher
    Traditionally, Tinospora cordifolia (Willd.) Hook. F. & Thomson (Menispermaceae), Ocimum sanctum L. (Lamiaceae), Moringa oleifera Lam. (Moringaceae), and Phyllanthus niruri L...
  16. Adhvaryu M, Reddy N, Vakharia B. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 2008;14:4753-62 pubmed
    To evaluate the ability of Curcuma longa (CL) and Tinospora cordifolia (TC) formulation to prevent anti-tuberculosis (TB) treatment (ATT) induced hepatotoxicity.
  17. Leyon P, Kuttan G. Effect of Tinospora cordifolia on the cytokine profile of angiogenesis-induced animals. Int Immunopharmacol. 2004;4:1569-75 pubmed
    The antiangiogenic activity of Tinospora cordifolia was studied using in vivo as well as in vitro models. In vivo antiangiogenic activity was studied using B16F10 melanoma cell-induced capillary formation in animals...
  18. Panchabhai T, Kulkarni U, Rege N. Validation of therapeutic claims of Tinospora cordifolia: a review. Phytother Res. 2008;22:425-41 pubmed publisher
    This review article attempts to correlate Ayurvedic pharmacology and therapeutic claims for Tinospora cordifolia (Tc) with the evidence generated using scientific research methodology...
  19. Singh N, Kumar A, Gupta P, Chand K, Samant M, Maurya R, et al. Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Parasitol Res. 2008;102:561-5 pubmed
    ..With this rationale, ethanolic extract of Tinospora sinensis Linn and its four fractions were tested in vitro against promastigotes and intracellular amastigotes ..
  20. Jahfar M, Azadi P. Glycosyl composition of polysaccharide from Tinospora cordifolia. II. Glycosyl linkages. Acta Pharm. 2004;54:73-8 pubmed
    Polysaccharide from Tinospora cordifolia was isolated, purified, methylated, hydrolyzed, reduced and acetylated. The partially methylated alditol acetate (PMAA) derivative thus obtained was subjected to GC-MS studies...
  21. Rout G. Identification of Tinospora cordifolia (Willd.) Miers ex Hook F & Thomas using RAPD markers. Z Naturforsch C. 2006;61:118-22 pubmed
    ..Studies were undertaken for identification and genetic variation within 15 clones of Tinospora cordifolia through random amplified polymorphic DNA (RAPD) markers...
  22. Pandey V, Shankar B, Sainis K. G1-4 A, an arabinogalactan polysaccharide from Tinospora cordifolia increases dendritic cell immunogenicity in a murine lymphoma model. Int Immunopharmacol. 2012;14:641-9 pubmed publisher
    ..In this study, we have investigated the effect of G1-4A, a polysaccharide isolated from Indian medicinal plant, Tinospora cordifolia on phenotypic and functional maturation of murine bone marrow derived dendritic cells (BMDC) and its ..
  23. Sengupta S, Mukherjee A, Goswami R, Basu S. Hypoglycemic activity of the antioxidant saponarin, characterized as alpha-glucosidase inhibitor present in Tinospora cordifolia. J Enzyme Inhib Med Chem. 2009;24:684-90 pubmed publisher
    b>Tinospora cordifolia, used in anti-diabetic herbal drug preparations, was reported [12] to contain an alpha-glucosidase inhibitor, characterized as saponarin (apigenin-6-C-glucosyl-7-O-glucoside)...
  24. Kapur P, Pereira B, Wuttke W, Jarry H. Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP. Phytomedicine. 2009;16:679-82 pubmed publisher
    Recently, Tinospora cordifolia (TC) was shown to affect prostate growth in rats. It is not known whether this is a direct effect of TC or whether it is induced by altered hormone release...
  25. Goel H, Prem Kumar I, Rana S. Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection. Indian J Exp Biol. 2002;40:727-34 pubmed
    ..The results reveal that the direct and indirect antioxidant actions of T. cordifolia probably act in corroboration to manifest the overall radioprotective effects...
  26. Ruan C, Lam S, Chi T, Lee S, Su M. Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice. Phytomedicine. 2012;19:719-24 pubmed publisher
    Diabetes mellitus (DM) often leads to disability from vascular complications and neurological complications. Tinospora crispa has been widely used in Asia and Africa as a remedy for diabetes and other diseases...
  27. Rao S, Rao P. Alteration in the radiosensitivity of HeLa cells by dichloromethane extract of guduchi (Tinospora cordifolia). Integr Cancer Ther. 2010;9:378-84 pubmed publisher
    Exposure of HeLa cells to TCE (dichloromethane extract of Tinospora cordifolia) for 4 hours before exposure to 2-Gy ?-radiation caused a significant decrease in the cell viability (approximately 50%)...
  28. Jagetia G, Rao S. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice. Biol Pharm Bull. 2006;29:460-6 pubmed
    The anticancer activity of dichloromethane extract of guduchi [Tinospora cordifolia (Willd.) Miers ex Hook. F. & Thoms. Family: Menispermaceae (TCE)] in the mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated...
  29. Reddy S, Ramatholisamma P, Karuna R, Saralakumari D. Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol. 2009;47:2224-9 pubmed publisher
    ..The aim of the present study was to investigate whether aqueous extract of Tinospora cordifolia stem (TCAE) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats...
  30. Subramanian M, Chintalwar G, Chattopadhyay S. Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage. Redox Rep. 2002;7:137-43 pubmed
    The antioxidant activity of an arabinogalactan polysaccharide (TSP) isolated from Tinospora cordifolia, an Indian medicinal plant, was studied...
  31. Singh N, Singh S, Shrivastava P. Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through activation of tumor-associated macrophages. Immunopharmacol Immunotoxicol. 2004;26:145-62 pubmed
    ..DL), a spontaneous transplantable T cell lymphoma, can be activated by the alcoholic extract of medicinal plant Tinospora cordifolia (ALTC)...
  32. Mishra A, Kumar S, Bhargava A, Sharma B, Pandey A. Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants. Cell Mol Biol (Noisy-le-grand). 2011;57:16-25 pubmed
    ..In the present study antioxidant and antistaphylococcal activities of Bauhinia variegata, Tinospora cardifolia and Piper longum have been determined...
  33. Aranha I, Clement F, Venkatesh Y. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). J Ethnopharmacol. 2012;139:366-72 pubmed publisher
    Guduchi (Tinospora cordifolia), a widely used plant in folk and Ayurvedic systems of medicine is well known for its immunomodulatory activity; however, the presence of an immunomodulatory protein (ImP) in guduchi has not been investigated.
  34. Choudhary M, Ismail M, Shaari K, Abbaskhan A, Sattar S, Lajis N, et al. cis-Clerodane-type furanoditerpenoids from Tinospora crispa. J Nat Prod. 2010;73:541-7 pubmed publisher
    Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new...
  35. Hamsa T, Kuttan G. Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels. Exp Toxicol Pathol. 2012;64:307-14 pubmed publisher
    ..In this study we investigated the effect of Tinospora cordifolia on urotoxicity induced by acute dose of CP using Swiss albino mice model...
  36. Sengupta M, Sharma G, Chakraborty B. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC Complement Altern Med. 2011;11:102 pubmed publisher
    ..The present study focuses on the immunostimulant properties of Tinospora cordifolia extract that are exerted on circulating macrophages isolated from CCl(4) (0...
  37. Dhanasekaran M, Baskar A, Ignacimuthu S, Agastian P, Duraipandiyan V. Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. Invest New Drugs. 2009;27:347-55 pubmed publisher
    ..10R)-4R, 8R-dihydroxy-2S, 3R:15, 16-diepoxycleroda-13(16), 17, 12S:18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular ..
  38. Sharma U, Bala M, Kumar N, Singh B, Munshi R, Bhalerao S. Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol. 2012;141:918-26 pubmed publisher
    b>Tinospora cordifolia mentioned as "Rasayana" is extensively used in various herbal preparations for the treatment of different ailments for its general tonic, antiperiodic, antispasmodic, antiinflammatory, antiarthritic, ..
  39. Koppada R, Norozian F, Torbati D, Kalomiris S, Ramachandran C, Totapally B. Physiological effects of a novel immune stimulator drug, (1,4)-?-D-glucan, in rats. Basic Clin Pharmacol Toxicol. 2009;105:217-21 pubmed publisher
    The (1,4)-?-D-glucan (?-D-glucan), derived from medicinal plant, Tinospora cordifolia, activates human lymphocytes with downstream synthesis of the pro- and anti-inflammatory cytokines, in vitro...
  40. Maurya R, Manhas L, Gupta P, Mishra P, Singh G, Yadav P. Amritosides A, B, C and D: clerodane furano diterpene glucosides from Tinospora cordifolia. Phytochemistry. 2004;65:2051-5 pubmed
    Four new clerodane furano diterpene glucosides (amritosides A, B, C and D) were isolated as their acetates from Tinospora cordifolia stems. The structures of these compounds were established on the basis of spectroscopic studies.
  41. Chougale A, Ghadyale V, Panaskar S, Arvindekar A. Alpha glucosidase inhibition by stem extract of Tinospora cordifolia. J Enzyme Inhib Med Chem. 2009;24:998-1001 pubmed publisher
    Inhibitors of alpha glucosidase have potential use in the treatment of diabetes mellitus. The stem extract of Tinospora cordifolia was evaluated for inhibition of the enzyme...
  42. Khan M, Harsha P, Giridhar P, Ravishankar G. Pigment identification, antioxidant activity, and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms fruit. Int J Food Sci Nutr. 2011;62:239-49 pubmed publisher
    The stem, leaf, and root of Tinospora cordifolia (willd.) have been highly exploited for medicinal preparations; however, the nutritional and nutraceutical potential of its attractive red berries (fruits) have not so far been studied...
  43. Mukherjee A, Ghosh A, Sengupta S. Purification and characterization of a thiol amylase over produced by a non-cereal non-leguminous plant, Tinospora cordifolia. Carbohydr Res. 2010;345:2731-5 pubmed publisher
    A 43kDa ?-amylase was purified from Tinospora cordifolia by glycogen precipitation, ammonium sulfate precipitation, gel filtration chromatography, and HPGPLC. The enzyme was optimally active in pH 6...
  44. Phan V, Chau V, Nguyen T, La V, Dan T, Nguyen H, et al. Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia. Fitoterapia. 2010;81:485-9 pubmed publisher
    Phytochemical investigation of the methanol extract of Tinospora cordifolia aerial parts led to the isolation of four new and seven known compounds...
  45. Patel M, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 2011;18:1045-52 pubmed publisher
    The stem of Tinospora cordifolia (TC) is widely used in the therapy of diabetes in traditional folk medicine of India. In the present study, isoquinoline alkaloid rich fraction (AFTC) derived from stem of TC and three alkaloids viz...
  46. Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar G, Sainis K. Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia. Immunol Lett. 2009;123:60-71 pubmed publisher
    G1-4A, a polysaccharide from an Indian medicinal plant Tinospora cordifolia, was recently shown to protect mice against septic shock by modulating the proinflammatory cytokines. G1-4A also activated B cells polyclonally...
  47. Pahadiya S, Sharma J. Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia. Phytother Res. 2003;17:552-4 pubmed
    b>Tinospora cordifolia is widely used in Ayurvedic medicines. It is known for its immunomodulatory, antihepatotoxic, antistress and antioxidant properties...
  48. Rao P, Kumar V, Viswanath R, Subbaraju G. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol Pharm Bull. 2005;28:2319-22 pubmed
    ..The present study was designed to investigate the effects of pretreatment with alcoholic extract of Tinospora cordifolia in an in vivo rat model...
  49. Singh S, Singh N, Shrivastava P. Effect of alcoholic extract of Ayurvedic herb Tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host. Fitoterapia. 2006;77:1-11 pubmed
    The present study investigates the effect of in vivo administration of alcoholic extract of Tinospora cordifolia whole plant (ALTC) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice ..
  50. Singh R. Tinospora cordifolia as an adjuvant drug in the treatment of hyper-reactive malarious splenomegaly--case reports. J Vector Borne Dis. 2005;42:36-8 pubmed
    The effect of aqueous extract of Tinospora cordifolia, an immunomodulator with antimalarial activity along with chloroquine was studied in the treatment of three cases of hyper-reactive malarious splenomegaly in District Hospital, ..
  51. Goel H, Prasad J, Singh S, Sagar R, Agrawala P, Bala M, et al. Radioprotective potential of an herbal extract of Tinospora cordifolia. J Radiat Res. 2004;45:61-8 pubmed
    A preparation of Tinospora cordifolia (RTc) administered i.p. (200 mg/kg b.w...
  52. Shivananjappa M, Muralidhara -. Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia. Nutrition. 2012;28:581-7 pubmed publisher
    ..In this study, we examined the propensity of Tinospora cordifolia (TC) to attenuate embryopathy and OS in pregnant diabetic rats.
  53. Nadig P, Revankar R, Dethe S, Narayanswamy S, Aliyar M. Effect of Tinospora cordifolia on experimental diabetic neuropathy. Indian J Pharmacol. 2012;44:580-3 pubmed publisher
    To evaluate the effect of aqueous extract of stem of Tinospora cordifolia (TC) on hyperalgesia in streptozotocin induced diabetic rats and in- vitro aldose reductase inhibition.
  54. Praman S, Mulvany M, Williams D, Andersen R, Jansakul C. Hypotensive and cardio-chronotropic constituents of Tinospora crispa and mechanisms of action on the cardiovascular system in anesthetized rats. J Ethnopharmacol. 2012;140:166-78 pubmed publisher
    b>Tinospora crispa has been used in folkloric medicine for the control of blood pressure...
  55. More P, Pai K. In vitro NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of macrophages after Tinospora cordifolia (guduchi) treatment. Immunopharmacol Immunotoxicol. 2012;34:368-72 pubmed publisher
    ..It was observed that the macrophage cell line J774A.1 when treated with Tinospora cordifolia (guduchi) and LPS showed enhanced NADH-oxidase, NADPH-oxidase and myeloperoxidase production as ..
  56. Abiramasundari G, Sumalatha K, Sreepriya M. Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro. J Ethnopharmacol. 2012;141:474-80 pubmed publisher
    Ancient Indian ayurvedic literature prescribes Tinospora cordifolia as a remedy to rheumatoid arthritis, inflammatory and allied diseases of musculo skeletal system.
  57. Panchabhai T, Ambarkhane S, Joshi A, Samant B, Rege N. Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study. Phytother Res. 2008;22:646-50 pubmed publisher
    This study investigated the hepatoprotective effect of two Indian medicinal plants Tinospora cordifolia (Tc), Phyllanthus emblica (Pe), and their combination, in a rat model of isoniazid, rifampicin and pyrazinamide induced hepatic ..
  58. Desai V, Ramkrishnan R, Chintalwar G, Sainis K. G1-4A, an immunomodulatory polysaccharide from Tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock. Int Immunopharmacol. 2007;7:1375-86 pubmed
    ..we have investigated the possibility of using an arabinogalactan polysaccharide, G1-4A, from the stem of Tinospora cordifolia, for protection against endotoxin induced sepsis...
  59. Singh N, Singh S, Shrivastava P. Effect of Tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells. Immunopharmacol Immunotoxicol. 2005;27:1-14 pubmed
    We and others previously have reported that extract prepared from medicinal plant Tinospora cordifolia shows a wide spectrum of immunoaugmentary effects...
  60. Rawal A, Muddeshwar M, Biswas S. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. BMC Complement Altern Med. 2004;4:11 pubmed
    ..Rubia cordifolia (RC), Fagonia cretica linn (FC) and Tinospora cordifolia (TC) have been reported to contain a wide variety of antioxidants and have been in use in the eastern ..
  61. Sangsuwan C, Udompanthurak S, Vannasaeng S, Thamlikitkul V. Randomized controlled trial of Tinospora crispa for additional therapy in patients with type 2 diabetes mellitus. J Med Assoc Thai. 2004;87:543-6 pubmed
    A randomized double blind placebo controlled trial was conducted to determine the efficacy of Tinospora crispa as additional treatment in patients with type 2 diabetes mellitus who did not respond to oral hypoglycemic drugs and refused ..
  62. Leyon P, Kuttan G. Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis. J Ethnopharmacol. 2004;90:233-7 pubmed
    Administration of the polysaccharide fraction from Tinospora cordifolia was found to be very effective in reducing the metastatic potential of B16F-10 melanoma cells...
  63. Grover J, Rathi S, Vats V. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens and Tinospora cordifolia) extracts. Indian J Exp Biol. 2002;40:273-6 pubmed
    ..M. charantia and E. jambolana modified it favorably while M. pruriens and T. cordifolia did not exert any favorable change...
  64. Rao S, Rao P, Rao B. Preliminary investigation of the radiosensitizing activity of guduchi (Tinospora cordifolia) in tumor-bearing mice. Phytother Res. 2008;22:1482-9 pubmed publisher
    The radiosensitizing activity of dichloromethane extract of guduchi [Tinospora cordifolia (WILLD.) MIERS ex HOOK. F. & THOMS...
  65. Prince P, Kamalakkannan N, Menon V. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats. Acta Pol Pharm. 2004;61:283-7 pubmed
    The present study investigates the effect of oral administration of an alcoholic extract of Tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats...
  66. Nair P, Rodriguez S, Ramachandran R, Alamo A, Melnick S, Escalon E, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol. 2004;4:1645-59 pubmed
    ..kDa and exhibiting unique immune stimulating properties is isolated and characterized from the medicinal plant Tinospora cordifolia...
  67. Kongkathip N, Dhumma upakorn P, Kongkathip B, Chawananoraset K, Sangchomkaeo P, Hatthakitpanichakul S. Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa. J Ethnopharmacol. 2002;83:95-9 pubmed
    This report describes the isolation of two triterpenes from the stems of Tinospora crispa, namely, cycloeucalenol (1). and cycloeucalenone (2). for the first time. It was found that cycloeucalenol (1)...