cissampelos

Summary

Summary: A plant genus of the family MENISPERMACEAE. Members contain eletefine (a stephaoxocane alkaloid) and tropoloisoquinoline and protoberberine ALKALOIDS.

Top Publications

  1. Nwafor S, Akah P. Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats. Indian J Exp Biol. 2003;41:181-3 pubmed
    Five fractions (F1-F5) isolated from the methanolic leaf extract of Cissampelos mucronata A. Rich were investigated for antiulcer activity...
  2. Bezerra Santos C, Balestieri F, Rossi Bergmann B, Peçanha L, Piuvezam M. Cissampelos sympodialis Eichl. (Menispermaceae): oral treatment decreases IgE levels and induces a Th1-skewed cytokine production in ovalbumin-sensitized mice. J Ethnopharmacol. 2004;95:191-7 pubmed
    ..OVA)-induced allergy was used to evaluate the effectiveness of oral treatment with the leaf extract of Cissampelos sympodialis Eichl...
  3. Alexandre Moreira M, Freire de Lima C, Trindade M, Castro Faria Neto H, Piuvezam M, Peçanha L. Cissampelos sympodialis Eichl (Menispermaceae) leaf extract induces interleukin-10-dependent inhibition of Trypanosoma cruzi killing by macrophages. Braz J Med Biol Res. 2003;36:199-205 pubmed
    The aqueous fraction of the ethanolic extract (AFL) of Cissampelos sympodialis Eichl (Menispermaceae), popularly known as milona, has been shown to have both immunosuppressive and anti-inflammatory effects...
  4. Marinho A, Barbosa Filho J, Oliveira E. A validated method for the simultaneous quantitation of bioactive alkaloid markers in the leaf ethanolic extract of Cissampelos sympodialis Eichl.: a phenological variation study. Phytochem Anal. 2012;23:426-32 pubmed publisher
    The leaf hydroalcoholic extract of Cissampelos sympodialis Eichl. (Menispermaceae) has shown promising activity in different animal models of asthma...
  5. Ramírez I, Carabot A, Meléndez P, Carmona J, Jimenez M, Patel A, et al. Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira. Phytochemistry. 2003;64:645-7 pubmed
    From the aerial parts of Cissampelos pareira L...
  6. Amresh -, Reddy G, Rao C, Shirwaikar A. Ethnomedical value of Cissampelos pareira extract in experimentally induced diarrhoea. Acta Pharm. 2004;54:27-35 pubmed
    The antidiarrhoeal activity of the ethanolic extract of Cissampelos pareira (Menispermaceae) roots was assessed on experimental animals. The hydroethanolic extract (25-100 mg dry extract kg(-1) body mass, p.o...
  7. Rocha J, Decote Ricardo D, Redner P, Lopes U, Barbosa Filho J, Piuvezam M, et al. Inhibitory effect of the alkaloid warifteine purified from Cissampelos sympodialis on B lymphocyte function in vitro and in vivo. Planta Med. 2010;76:325-30 pubmed publisher
    The aqueous fraction of the ethanolic extract of the plant CISSAMPELOS SYMPODIALIS (Menispermaceae) was previously described to inhibit B cell function. The alkaloid warifteine is the major component of this extract...
  8. Tshibangu J, Wright A, König G. HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata. Phytochem Anal. 2003;14:13-22 pubmed
    The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum...
  9. Porto N, de Figueiredo R, Oliveira A, de Fátima Agra M. Leaf epidermal characteristics of Cissampelos L. (Menispermaceae) species from Northeastern Brazil. Microsc Res Tech. 2011;74:370-6 pubmed publisher
    The morphological similarities among the species of Cissampelos are remarkable and the difficult to distinguish them as well...

More Information

Publications39

  1. Ganguly M, Kr Borthakur M, Devi N, Mahanta R. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice. J Ethnopharmacol. 2007;111:688-91 pubmed
    meenakshi Cissampelos pareira Linn. is one of the folk medicinal plants commonly used as antifertility agent in some places of India...
  2. Amresh G, Singh P, Rao C. Antinociceptive and antiarthritic activity of Cissampelos pareira roots. J Ethnopharmacol. 2007;111:531-6 pubmed
    In the present study, 50% aqueous ethanolic extract of Cissampelos pareira (Menispermaceae) roots (C. pareira) at the dose levels of 100-400 mg/kg, once daily for 3 days exhibited significant (P < 0...
  3. Bezerra Santos C, Vieira de Abreu A, Barbosa Filho J, Bandeira Melo C, Piuvezam M, Bozza P. Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine. Int Immunopharmacol. 2006;6:1152-60 pubmed
    ..Here, we evaluated the anti-allergic properties of an extract of the Brazilian Menispermaceae Cissampelos sympodialis, focusing on its effects on allergic eosinophilia...
  4. Melo P, de Medeiros Cavalcante H, Barbosa Filho J, de Fátima Formiga Melo Diniz M, de Medeiros I, Haun M. Warifteine and milonine, alkaloids isolated from Cissampelos sympodialis Eichl: cytotoxicity on rat hepatocyte culture and in V79 cells. Toxicol Lett. 2003;142:143-51 pubmed
    Two alkaloids were isolated from the leaves of Cissampelos sympodialis; a bisbenzylisoquinoline compound named warifteine and a novel 8,14-dihydromorphinandienone alkaloid named milonine...
  5. Alexandre Moreira M, Piuvezam M, Peçanha L. Modulation of B lymphocyte function by an aqueous fraction of the ethanol extract of Cissampelos sympodialis Eichl (Menispermaceae). Braz J Med Biol Res. 2003;36:1511-22 pubmed
    b>Cissampelos sympodialis Eichl species are used in folk medicine for the treatment of asthma, arthritis and rheumatism...
  6. Amresh G, Reddy G, Rao C, Singh P. Evaluation of anti-inflammatory activity of Cissampelos pareira root in rats. J Ethnopharmacol. 2007;110:526-31 pubmed
    In the present study, 50% ethanolic extract of Cissampelos pareira roots (CPE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o...
  7. Bezerra Santos C, Vieira de Abreu A, Vieira G, Filho J, Barbosa Filho J, Pires A, et al. Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma. Int Immunopharmacol. 2012;13:148-55 pubmed publisher
    b>Cissampelos sympodialis Eichl. (Menispermaceae) is a plant found in Northeastern and Southeast of Brazil and hot water infusion of C...
  8. Sood R, Raut R, Tyagi P, Pareek P, Barman T, Singhal S, et al. Cissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus Serotypes. PLoS Negl Trop Dis. 2015;9:e0004255 pubmed publisher
    ..Our results show that the alcoholic extract of Cissampelos pariera Linn (Cipa extract) was a potent inhibitor of all four DENVs in cell-based assays, assessed in terms of ..
  9. de Sales I, Machado F, Marinho A, Lúcio A, Barbosa Filho J, Batista L. Cissampelos sympodialis Eichl. (Menispermaceae), a medicinal plant, presents antimotility and antidiarrheal activity in vivo. BMC Complement Altern Med. 2015;15:253 pubmed publisher
    b>Cissampelos sympodialis (Menispermaceae), known as "Milona" has a specific verified medicinal use for the treatment of diarrhea and respiratory tract diseases...
  10. Vijayan D, Cheethaparambil A, Pillai G, Balachandran I. Molecular authentication of Cissampelos pareira L. var. hirsuta (Buch.-Ham. ex DC.) Forman, the genuine source plant of ayurvedic raw drug 'Patha', and its other source plants by ISSR markers. 3 Biotech. 2014;4:559-562 pubmed publisher
    b>Cissampelos pareira L. var. hirsuta (Buch.-Ham. ex DC.) Forman belongs to family Menispermaceae. The roots of this taxon are used in the treatment of various diseases like stomach pain, fever, skin disease, etc...
  11. Giovannini P, Howes M. Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence. J Ethnopharmacol. 2017;199:240-256 pubmed publisher
    ..Only nine species were reported in at least three studies: Cissampelos pareira L., Piper amalago L., Aristolochia trilobata L., Sansevieria hyacinthoides (L...
  12. Alves M, Scotti M, Scotti L, Mendonça F, Filho J, de Melo S, et al. Secondary Metabolites from Cissampelos, A Possible Source for New Leads with Anti-Inflammatory Activity. Curr Med Chem. 2017;24:1629-1644 pubmed publisher
    The genus Cissampelos comprises of 21 species which have a wide global distribution and various pharmacological activities such as analgesic and antipyretic, antiinflammatory, anti-allergic, bronchodilation, and immunomodulation among ..
  13. Akhalwaya S, van Vuuren S, Patel M. An in vitro investigation of indigenous South African medicinal plants used to treat oral infections. J Ethnopharmacol. 2018;210:359-371 pubmed publisher
    ..The organic extract of Cissampelos torulosa stems displayed the lowest MIC value of 0.05mg/mL against both Lactobacillus spp...
  14. Silva L, Alves A, Cavalcante Silva L, Braga R, de Almeida R, Barbosa Filho J, et al. Milonine, a Morphinandienone Alkaloid, Has Anti-Inflammatory and Analgesic Effects by Inhibiting TNF-? and IL-1? Production. Inflammation. 2017;40:2074-2085 pubmed publisher
    Milonine is a morphinandienone alkaloid from Cissampelos sympodialis Eichl (Menispermaceae), a plant used in Brazil to treat inflammatory disorders...
  15. Ricciardi Verrastro B, Maria Torres A, Ricciardi G, Teibler P, Maruñak S, Barnaba C, et al. The effects of Cissampelos pareira extract on envenomation induced by Bothropsdiporus snake venom. J Ethnopharmacol. 2018;212:36-42 pubmed publisher
    ..diporus is responsible for 80% of them. In the northeast of the country (Corrientes Provinces), Cissampelos pareira L. (Menispermaceae) is commonly used against the venom of B...
  16. Singh P, Rawat P. Evolving herbal formulations in management of dengue fever. J Ayurveda Integr Med. 2017;8:207-210 pubmed publisher
    ..Azadirachta indica, Carica papaya, Hippophae rhamnoides and Cissampelos pareira extracts were found effective and demonstrated improvement in clinical symptoms and direct inhibitory ..
  17. Bala M, Kumar S, Pratap K, Verma P, Padwad Y, Singh B. Bioactive isoquinoline alkaloids from Cissampelos pareira. Nat Prod Res. 2017;:1-6 pubmed publisher
    The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), ..
  18. Alves A, Vieira G, Gadelha F, Cavalcante Silva L, Martins M, Barbosa Filho J, et al. Milonine, an Alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae) Inhibits Histamine Release of Activated Mast Cells. Inflammation. 2017;40:2118-2128 pubmed publisher
    Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions...
  19. Alves M, Ferreira L, Gadelha F, Ferreira L, Felix M, Scotti M, et al. Toxicological evaluation in silico and in vivo of secondary metabolites of Cissampelos sympodialis in Mus musculus mice following inhalation. Nat Prod Res. 2017;:1-7 pubmed publisher
    The ethanolic extract of the leaves of Cissampelos sympodialis showed great pharmacological potential, with inflammatory and immunomodulatory activities, however, it showed some toxicological effects...
  20. Singh B, Pillai K, Kohli K, Haque S. Cissampelos pareira Linn. ameliorates thyroxin-induced cardiac hypertrophy in rats. J Ethnopharmacol. 2016;178:281-8 pubmed publisher
    b>Cissampelos pareira extract has been traditionally used in ayruveda as cardiotonic, diuretics and in heart complains but its pharmacological evaluation in thyroxin-induced cardiac hypertrophy has not yet been explored...
  21. Cavalcanti da Silva E, Dias Rayol C, Medeiros P, Figueiredo R, Piuvezan M, Brabosa Filho J, et al. Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae). ScientificWorldJournal. 2012;2012:516408 pubmed publisher
    ..This bisbenzylisoquinoline alkaloid was isolated from the leaves and roots of Cissampelos sympodialis Eichl...
  22. Surendran S, Eswaran M, Vijayakumar M, Rao C. In vitro and in vivo hepatoprotective activity of Cissampelos pareira against carbon-tetrachloride induced hepatic damage. Indian J Exp Biol. 2011;49:939-45 pubmed
    Administration of hydroalcoholic extract of Cissampelos pareira roots (CPRE) and standard drug silymarin in rats showed significant hepatoprotective action against CCl4 induced hepatotoxicity...
  23. Nondo R, Mbwambo Z, Kidukuli A, Innocent E, Mihale M, Erasto P, et al. Larvicidal, antimicrobial and brine shrimp activities of extracts from Cissampelos mucronata and Tephrosia villosa from coast region, Tanzania. BMC Complement Altern Med. 2011;11:33 pubmed publisher
    The leaves and roots of Cissampelos mucronata A. Rich (Menispermaceae) are widely used in the tropics and subtropics to manage various ailments such as gastro-intestinal complaints, menstrual problems, venereal diseases and malaria...
  24. Lorenzo V, Alves M, Scotti L, Dos Santos S, de Fátima Formiga Melo Diniz M, Scotti M. Computational Chemistry Study of Natural Alkaloids and Homemade Databank to Predict Inhibitory Potential Against Key Enzymes in Neurodegenerative Diseases. Curr Top Med Chem. 2017;17:2926-2934 pubmed publisher
    b>Cissampelos sympodialis Eichl is used in folk medicine for the treatment of various inflammatory diseases; several alkaloids have been isolated from this species and some of them have anti-allergic, immunomodulatory and spasmolytic ..
  25. Amresh G, Singh P, Rao C. Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals. J Ethnopharmacol. 2008;116:454-60 pubmed publisher
    Laghupatha (Cissampelos pareira) a important medicinal plant in Indian traditional system of medicine and is widely used in many countries by different tribal...
  26. Ayers S, Zink D, Mohn K, Powell J, Brown C, Murphy T, et al. Anthelmintic activity of aporphine alkaloids from Cissampelos capensis. Planta Med. 2007;73:296-7 pubmed
    ..S)-dicentrine (1) and (S)-neolitsine (2), have been isolated from the MeOH extract of the aerial parts of Cissampelos capensis (Menispermaceae)...
  27. Costa H, Leite F, Alves A, Barbosa Filho J, dos Santos C, Piuvezam M. Managing murine food allergy with Cissampelos sympodialis Eichl (Menispermaceae) and its alkaloids. Int Immunopharmacol. 2013;17:300-8 pubmed publisher
    Food allergy is a severe human disease with imminent risk of life. Cissampelos sympodialis (Menispermaceae) is a native Brazilian plant used in Brazilian folk medicine for the treatment of respiratory allergies...
  28. Vieira G, De Lima J, De Figueiredo R, Mascarenhas S, Bezerra Santos C, Piuvezam M. Inhaled Cissampelos sympodialis down-regulates airway allergic reaction by reducing lung CD3+ T cells. Phytother Res. 2013;27:916-25 pubmed publisher
    b>Cissampelos sympodialis Eichl. (Menispermaceae) root infusion is used in Northeast Brazil to treat allergic asthma...
  29. Cerqueira Lima A, Alcantara Neves N, de Carvalho L, Costa R, Barbosa Filho J, Piuvezam M, et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Curr Drug Targets. 2010;11:1458-67 pubmed
    ..Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory ..
  30. Almeida R, Melo Diniz M, Medeiros I, Quintans Júnior L, Navarro D, Falcão A, et al. Anorectic and behavioural effects of chronic Cissampelos sympodialis treatment in female and male rats. Phytother Res. 2005;19:121-4 pubmed
    Male and female rats were treated daily for 13 weeks with an ethanol extract of Cissampelos sympodialis leaves (9, 45 and 225 mg[sol ]kg)...