hibiscus

Summary

Summary: A plant genus of the family MALVACEAE. Members contain CITRIC ACID; MALATES; ANTHOCYANINS; FLAVONOIDS; GLYCOSIDES; DIETARY FIBER; and LIGNANS. Hibiscus sabdariffa is common constituent of HERBAL TEAS. Hibiscus cannabinus is a source of hemp fiber for TEXTILES.

Top Publications

  1. Ali B, Mousa H, El Mougy S. The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats. Phytother Res. 2003;17:56-9 pubmed
    We investigated the effect of the water extract of the dried flowers of Hibiscus sabdariffa L. and Hibiscus anthocyanins (HAs) (which are a group of natural pigments occurring in the dried calyx of H...
  2. Telefo P, Moundipa P, Tchouanguep F. Oestrogenicity and effect on hepatic metabolism of the aqueous extract of the leaf mixture of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis. Fitoterapia. 2002;73:472-8 pubmed
    The aqueous extract of the leaf mixtures of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis given by oral route to immature female rats, at doses of 13, 49 and 94 mg/kg per day for 15 days induced a ..
  3. Adhirajan N, Ravi Kumar T, Shanmugasundaram N, Babu M. In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. J Ethnopharmacol. 2003;88:235-9 pubmed
    Petroleum ether extract of leaves and flowers of Hibiscus rosa-sinensis was evaluated for its potential on hair growth by in vivo and in vitro methods...
  4. Sachdewa A, Khemani L. Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats. J Ethnopharmacol. 2003;89:61-6 pubmed
    ..were determined in streptozotocin induced diabetic rats after oral administration of an ethanol flower extract of Hibiscus rosa sinensis...
  5. Sharma S, Khan N, Sultana S. Study on prevention of two-stage skin carcinogenesis by Hibiscus rosa sinensis extract and the role of its chemical constituent, gentisic acid, in the inhibition of tumour promotion response and oxidative stress in mice. Eur J Cancer Prev. 2004;13:53-63 pubmed
    We designed the present study to investigate the role of gentisic acid in the chemopreventive activity of Hibiscus rosa sinensis extract on 7,12-dimethyl benz(a)anthracene (DMBA)/croton oil-mediated carcinogenesis in mouse skin via 12-O-..
  6. Yin G, Cao L, Xu P, Jeney G, Nakao M. Hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract against carbon tetrachloride-induced hepatocyte damage in Cyprinus carpio. In Vitro Cell Dev Biol Anim. 2011;47:10-5 pubmed publisher
    The present study aims to evaluate the hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract on the carbon tetrachloride (CCl(4))-induced hepatocyte damage in fish and provide evidence as to whether it can be potentially ..
  7. Shivananda Nayak B, Sivachandra Raju S, Orette F, Chalapathi Rao A. Effects of Hibiscus rosa sinensis L (Malvaceae) on wound healing activity: a preclinical study in a Sprague Dawley rat. Int J Low Extrem Wounds. 2007;6:76-81 pubmed
    b>Hibiscus rosa sinensis (H rosa sinensis), a plant product, has been used for the treatment of a variety of diseases as well as to promote wound healing...
  8. Mojiminiyi F, Dikko M, Muhammad B, Ojobor P, Ajagbonna O, Okolo R, et al. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia. 2007;78:292-7 pubmed
    The present study was designed to investigate the efficacy of an aqueous calyx extract of Hibiscus sabdariffa (HS) in two forms of experimental hypertension: salt-induced and L-NAME (N(omega)-L-arginine methyl ester)-induced and in ..
  9. Salah A, Gathumbi J, Vierling W. Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats. Phytother Res. 2002;16:283-5 pubmed
    The methanol extracts of Hibiscus sabdariffa (p < 0.01) showed a significant dose dependent relaxant effect (IC50) = 350 microM) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds...

More Information

Publications103 found, 100 shown here

  1. Yang Y, Wang C, Huang C, Chen M, Chen M, Peng C. Polyphenols of Hibiscus sabdariffa improved diabetic nephropathy via attenuating renal epithelial mesenchymal transition. J Agric Food Chem. 2013;61:7545-51 pubmed publisher
    We previously reported that Hibiscus sabdariffa polyphenol extracts (HPE) are beneficial for diabetic nephropathy...
  2. Shui G, Peng L. An improved method for the analysis of major antioxidants of Hibiscus esculentus Linn. J Chromatogr A. 2004;1048:17-24 pubmed
    Major antioxidants of aqueous ethanol extract from Lady's Finger (Hibiscus esculentus Linn) were systematically investigated in this study...
  3. Ochani P, D Mello P. Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and calyces extracts in rats. Indian J Exp Biol. 2009;47:276-82 pubmed
    Antioxidant and antihyperlipidemic activities of the extracts of leaves and calyces of Hibiscus sabdariffa were investigated by studying their in vitro inhibitory activity on lipid peroxidation and in vivo effects on cholesterol induced ..
  4. Ramirez Rodrigues M, Plaza M, Azeredo A, Balaban M, Marshall M. Physicochemical and phytochemical properties of cold and hot water extraction from?Hibiscus sabdariffa. J Food Sci. 2011;76:C428-35 pubmed publisher
    b>Hibiscus cold (25 °C) and hot (90 °C) water extracts were prepared in various time-temperature combinations to determine equivalent extraction conditions regarding their physicochemical and phytochemical properties...
  5. Segura Carretero A, Puertas Mejía M, Cortacero Ramírez S, Beltran R, Alonso Villaverde C, Joven J, et al. Selective extraction, separation, and identification of anthocyanins from Hibiscus sabdariffa L. using solid phase extraction-capillary electrophoresis-mass spectrometry (time-of-flight /ion trap). Electrophoresis. 2008;29:2852-61 pubmed publisher
    ..exact masses and fragmentation patterns has been developed in order to know the anthocyanins in dried calyces of Hibiscus sabdariffa L...
  6. Huang C, Chan K, Lin W, Su S, Wang C, Peng C. Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose--a mechanism involves connective tissue growth factor signals. J Agric Food Chem. 2009;57:3073-9 pubmed publisher
    Recently, the herbal extract of Hibiscus sabdariffa was shown to have multiple bioactive effects, including anti-atherosclerosis. On the basis of this, we aimed to examine whether the polyphenolic isolate of H...
  7. Beltran Debon R, Alonso Villaverde C, Aragones G, Rodríguez Medina I, Rull A, Micol V, et al. The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans. Phytomedicine. 2010;17:186-91 pubmed publisher
    ..The aqueous extract of Hibiscus sabdariffa is rich in anthocyanins and other phenolic compounds including hydroxycitric and chlorogenic acids...
  8. Atawodi S, Atawodi J, Idakwo G, Pfundstein B, Haubner R, Wurtele G, et al. Polyphenol composition and antioxidant potential of Hibiscus esculentus L. fruit cultivated in Nigeria. J Med Food. 2009;12:1316-20 pubmed publisher
    ..Polyphenols, a heterogeneous group of compounds, are one of these constituents. Hibiscus esculentus L...
  9. Wu L, Tang T, Zhou R, Shi S. PCR-mediated recombination of the amplification products of the Hibiscus tiliaceus cytosolic glyceraldehyde-3-phosphate dehydrogenase gene. J Biochem Mol Biol. 2007;40:172-9 pubmed
    ..Here, we report on the occurrence of PCR-mediated recombination in the GapC gene family of Hibiscus tiliaceus...
  10. Liu L, Wang C, Lee C, Su S, Chen H, Hsu J, et al. Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models. J Sci Food Agric. 2010;90:329-37 pubmed publisher
    ..Acetaminophen (AAP)-induced oxidative stress can cause cell death to induce liver damage. The antioxidant effect of Hibiscus sabdariffa L. (HS) was shown in previous studies...
  11. Li D, Li X, Li T, Dang H, Proksch P, Wang B. Benzaldehyde derivatives from Eurotium rubrum, an endophytic fungus derived from the mangrove plant Hibiscus tiliaceus. Chem Pharm Bull (Tokyo). 2008;56:1282-5 pubmed
    ..of Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus. The structures of these compounds were determined by extensive analysis of their spectroscopic data...
  12. Liu J, Chen C, Wang W, Hsu J, Yang M, Wang C. The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem Toxicol. 2006;44:336-43 pubmed
    Dried flower Hibiscus sabdariffa L. (HSE) extracts, a local soft drink material and medicinal herb, were studied for their protective effects against liver fibrosis induced using carbon tetrachloride (CCl(4)) in rats...
  13. Alarcon Aguilar F, Zamilpa A, Perez Garcia M, Almanza Perez J, Romero Nuñez E, Campos Sepulveda E, et al. Effect of Hibiscus sabdariffa on obesity in MSG mice. J Ethnopharmacol. 2007;114:66-71 pubmed
    The aim of the present investigation was determine whether a standardized Hibiscus sabdariffa calyces aqueous extract has an effect on body weight in an obese animal model induced by the administration of monosodium glutamate...
  14. Hritcu L, Foyet H, Stefan M, Mihasan M, Asongalem A, Kamtchouing P. Neuroprotective effect of the methanolic extract of Hibiscus asper leaves in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. J Ethnopharmacol. 2011;137:585-91 pubmed publisher
    While the Hibiscus asper Hook.f...
  15. Ojeda D, Jimenez Ferrer E, Zamilpa A, Herrera Arellano A, Tortoriello J, Alvarez L. Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa. J Ethnopharmacol. 2010;127:7-10 pubmed publisher
    The beverages of Hibiscus sabdariffa calyces are widely used in Mexico as diuretic, for treating gastrointestinal disorders, liver diseases, fever, hypercholesterolemia and hypertension...
  16. Mohamed R, Fernandez J, Pineda M, Aguilar M. Roselle (Hibiscus sabdariffa) seed oil is a rich source of gamma-tocopherol. J Food Sci. 2007;72:S207-11 pubmed
    The antioxidant potential of roselle (Hibiscus sabdariffa L.) extracts was studied...
  17. Sukwattanasinit T, Burana Osot J, Sotanaphun U. Spectrophotometric method for quantitative determination of total anthocyanins and quality characteristics of roselle (Hibiscus sabdariffa). Planta Med. 2007;73:1517-22 pubmed
    ..Total contents of anthocyanins and phenolics were proportional to the antiradical capacity. ..
  18. Yusri N, Chan K, Iqbal S, Ismail M. Phenolic content and antioxidant activity of Hibiscus cannabinus L. seed extracts after sequential solvent extraction. Molecules. 2012;17:12612-21 pubmed publisher
    A sequential solvent extraction scheme was employed for the extraction of antioxidant compounds from kenaf (Hibiscus cannabinus L.) seeds. Yield of extracts varied widely among the solvents and was the highest for hexane extract (16...
  19. Frank T, Janssen M, Netzel M, Strass G, Kler A, Kriesl E, et al. Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J Clin Pharmacol. 2005;45:203-10 pubmed
    Pharmacokinetic parameters of several dietary anthocyanins following consumption of Hibiscus sabdariffa L. extract were determined in 6 healthy volunteers. Subjects were given a single oral dose of 150 mL of Hibiscus sabdariffa L...
  20. Yang M, Peng C, Chan K, Yang Y, Huang C, Wang C. The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. J Agric Food Chem. 2010;58:850-9 pubmed publisher
    b>Hibiscus sabdariffa extract (HSE) was shown to lower the plasma lipid level and reduce the liver damage...
  21. Gurrola Díaz C, García López P, Sánchez Enríquez S, Troyo Sanroman R, Andrade González I, Gómez Leyva J. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomedicine. 2010;17:500-5 pubmed publisher
    ..Currently, the antihypertensive and hypolipidemic properties of aqueous Hibiscus sabdariffa extracts (HSE) have been demonstrated in clinical trials and in vivo experiments...
  22. Herrera Arellano A, Flores Romero S, Chavez Soto M, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine. 2004;11:375-82 pubmed
    In order to compare the antihypertensive effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa with captopril, a controlled and randomized clinical trial was done...
  23. Rosa R, Melecchi M, da Costa Halmenschlager R, Abad F, Simoni C, Caramão E, et al. Antioxidant and antimutagenic properties of Hibiscus tiliaceus L. methanolic extract. J Agric Food Chem. 2006;54:7324-30 pubmed
    The genus Hibiscus thrives in a variety of climates and produces a diversity of natural compounds with bioactive properties. We have studied the chemical composition and the in vivo antioxidant properties of Hibiscus tiliaceus L...
  24. Srinivasan K, Min B, Ryu K, Adkins S, Wong S. Determination of complete nucleotide sequence of Hibiscus latent Singapore virus: evidence for the presence of an internal poly(A) tract. Arch Virol. 2005;150:153-66 pubmed publisher
    We have sequenced the complete genome of a hibiscus-infecting tobamovirus, Hibiscus latent Singapore virus (HLSV)...
  25. Venkatesh S, Thilagavathi J, Shyam Sundar D. Anti-diabetic activity of flowers of Hibiscus rosasinensis. Fitoterapia. 2008;79:79-81 pubmed
    The ethanol extract of flowers of Hibiscus rosasinensis at doses of 250 mg/kg and 500 mg/kg significantly reduced the blood glucose level in both acute (1, 3, 5 h) and sub acute (1, 3, 5, 7 days) treatments.
  26. Lin H, Huang H, Huang C, Chen J, Wang C. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog. 2005;43:86-99 pubmed
    ..b>Hibiscus sabdariffa Linne (Malvaceae), an attractive plant believed to be native to Africa, is cultivated in the Sudan and ..
  27. Odigie I, Ettarh R, Adigun S. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J Ethnopharmacol. 2003;86:181-5 pubmed
    The effect of aqueous extract of petals of Hibiscus sabdariffa (HS) on the established stages of 2-Kidney, 1-Clip renovascular hypertension was investigated in Sprague-Dawley rats...
  28. Takayama K, Ohi Toma T, Kudoh H, Kato H. Origin and diversification of Hibiscus glaber, species endemic to the oceanic Bonin Islands, revealed by chloroplast DNA polymorphism. Mol Ecol. 2005;14:1059-71 pubmed publisher
    Abstract Two woody Hibiscus species co-occur in the Bonin Islands of the northwestern Pacific Ocean: Hibiscus glaber Matsum. is endemic to the islands, and its putative ancestral species, Hibiscus tiliaceus L...
  29. Moundipa P, Beboy N, Zelefack F, Ngouela S, Tsamo E, Schill W, et al. Effects of Basella alba and Hibiscus macranthus extracts on testosterone production of adult rat and bull Leydig cells. Asian J Androl. 2005;7:411-7 pubmed
    To determine the androgenic effects of Basella alba and Hibiscus macranthus extracts in the rat and the bull, and to develop a novel in vitro test system using Leydig cells from bull testes...
  30. Ebrahimzadeh M, Nabavi S, Nabavi S. Antidepressant activity of Hibiscus esculentus L. Eur Rev Med Pharmacol Sci. 2013;17:2609-12 pubmed
    b>Hibiscus (H.) esculentus L. (Okra) is distributed from Africa to Asia, Southern European and America and widely used as food. The aim of present study was to investigate antidepressant activity of Okra seeds and leaves...
  31. Gutierrez A, Rodríguez I, Del Río J. Chemical characterization of lignin and lipid fractions in kenaf bast fibers used for manufacturing high-quality papers. J Agric Food Chem. 2004;52:4764-73 pubmed
    The chemical composition of lignin and lipids of bast fibers from kenaf (Hibiscus cannabinus) used for high-quality paper pulp production was studied...
  32. Hirunpanich V, Utaipat A, Morales N, Bunyapraphatsara N, Sato H, Herunsale A, et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 2006;103:252-60 pubmed
    The present study was designed to investigate the hypolipidemic effects and antioxidant effects of Hibiscus sabdariffa L...
  33. Lin H, Chen J, Kuo W, Wang C. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem Biol Interact. 2007;165:59-75 pubmed
    ..b>Hibiscus sabdariffa Linne (Malvaceae), an attractive plant believed to be native to Africa, is cultivated in the Sudan and ..
  34. Gao R, Ng F, Liu P, Wong S. Hibiscus chlorotic ringspot virus coat protein upregulates sulfur metabolism genes for enhanced pathogen defense. Mol Plant Microbe Interact. 2012;25:1574-83 pubmed publisher
    In both Hibiscus chlorotic ringspot virus (HCRSV)-infected and HCRSV coat protein (CP) agroinfiltrated plant leaves, we showed that sulfur metabolism pathway related genes-namely, sulfite oxidase (SO), sulfite reductase, and adenosine 5'-..
  35. Peng C, Chyau C, Chan K, Chan T, Wang C, Huang C. Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. J Agric Food Chem. 2011;59:9901-9 pubmed publisher
    ..In conclusion, we demonstrated the anti-insulin resistance properties of HPE and its effect on hypoglycemia, hypolipidemia, and antioxidation. HPE has the potential to be an adjuvant for diabetic therapy...
  36. Visi D, D Souza N, Ayre B, Webber Iii C, Allen M. Investigation of the bacterial retting community of kenaf (Hibiscus cannabinus) under different conditions using next-generation semiconductor sequencing. J Ind Microbiol Biotechnol. 2013;40:465-75 pubmed publisher
    The microbial communities associated with kenaf (Hibiscus cannabinus) plant fibers during retting were determined in an effort to identify possible means of accelerating this process for industrial scale-up...
  37. Amin A, Hamza A. Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci. 2005;77:266-78 pubmed
    ..report, we used water extracts of three herbal plants that have been commonly used for treating many illnesses (Hibiscus sabdariffa, Rosmarinus officinalis and Salvia officinalis)...
  38. Chen J, Huang S, Duh C, Chen I, Wang T, Fang H. A new cytotoxic amide from the stem wood of Hibiscus tiliaceus. Planta Med. 2006;72:935-8 pubmed
    ..and stigmasterol, a mixture of beta-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses...
  39. Takayama K, Kajita T, Murata J, Tateishi Y. Phylogeography and genetic structure of Hibiscus tiliaceus--speciation of a pantropical plant with sea-drifted seeds. Mol Ecol. 2006;15:2871-81 pubmed
    Phylogenetic relationships and the spatial genetic structure of a pantropical plant with sea-drifted seeds, Hibiscus tiliaceus L., and its allied species were investigated...
  40. Gauthaman K, Saleem M, Thanislas P, Prabhu V, Krishnamoorthy K, Devaraj N, et al. Cardioprotective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat. BMC Complement Altern Med. 2006;6:32 pubmed
    The present study investigates the cardioprotective effects of Hibiscus rosa sinensis in myocardial ischemic reperfusion injury, particularly in terms of its antioxidant effects.
  41. Fakeye T, Pal A, Bawankule D, Yadav N, Khanuja S. Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytother Res. 2009;23:412-6 pubmed publisher
    The effects of a 90-day oral administration of water and alcohol extracts of dried calyx of Hibiscus sabdariffa were evaluated in albino rats. Haematological, biochemical and histopathological changes were monitored every 30 days...
  42. Zhang X, Wong S. Hibiscus chlorotic ringspot virus upregulates plant sulfite oxidase transcripts and increases sulfate levels in kenaf (Hibiscus cannabinus L.). J Gen Virol. 2009;90:3042-50 pubmed publisher
    b>Hibiscus chlorotic ringspot virus (HCRSV) coat protein (CP) is required for encapsidation and virus systemic movement...
  43. Hou D, Tong X, Terahara N, Luo D, Fujii M. Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys. 2005;440:101-9 pubmed
    Delphinidin 3-sambubioside (Dp3-Sam), a Hibiscus anthocyanin, was isolated from the dried calices of Hibiscus sabdariffa L...
  44. Gilani A, Bashir S, Janbaz K, Shah A. Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea. J Ethnopharmacol. 2005;102:289-94 pubmed
    The aqueous-ethanolic extract of the aerial parts of Hibiscus rosasinensis Linn...
  45. Herrera Arellano A, Miranda Sánchez J, Avila Castro P, Herrera Alvarez S, Jiménez Ferrer J, Zamilpa A, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007;73:6-12 pubmed
    b>Hibiscus sabdariffa L. (Malvaceae) has been used in different countries as an antihypertensive...
  46. Li L, Sattler I, Deng Z, Groth I, Walther G, Klaus Dieter Menzel -, et al. A-seco-oleane-type triterpenes from Phomopsis sp. (strain HKI0458) isolated from the mangrove plant Hibiscus tiliaceus. Phytochemistry. 2008;69:511-7 pubmed
    From the fermentation broth of an unidentified Phomopsis sp. (strain HKI0458) isolated from the mangrove plant Hibiscus tiliaceus, four A-seco-oleane-type triterpenes, namely 3,4-seco-olean-11,13-dien-4,15alpha, 22beta,24-tetraol-3-oic ..
  47. Farombi E, Ige O. Hypolipidemic and antioxidant effects of ethanolic extract from dried calyx of Hibiscus sabdariffa in alloxan-induced diabetic rats. Fundam Clin Pharmacol. 2007;21:601-9 pubmed
    The present study investigated the hypolipidemic and antioxidant effects of ethanolic extract of Hibiscus sabdariffa L (HSE) in rats treated with alloxan. The results were compared with the standard hypolipidemic drug lovastatin...
  48. Olaleye M, Rocha B. Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system. Exp Toxicol Pathol. 2008;59:319-27 pubmed
    ..protective effects of administration (100mg/kg) of some medicinal plants (Kigelia africana, Calotropis procera, Hibiscus sabdariffa and Alchornea cordifolia) on PCM-induced liver damage in mice...
  49. Kao E, Tseng T, Lee H, Chan K, Wang C. Anthocyanin extracted from Hibiscus attenuate oxidized LDL-mediated foam cell formation involving regulation of CD36 gene. Chem Biol Interact. 2009;179:212-8 pubmed
    ..b>Hibiscus sabdariffa L...
  50. Telefo P, Moundipa P, Tchouanguep F. Inductive effect of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus on in vitro production of estradiol. J Ethnopharmacol. 2004;91:225-30 pubmed
    ..of the mechanisms of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus, locally used to regulate the menstrual cycle and to treat dysmenorrhea or cases of infertility in ..
  51. Carvajal Zarrabal O, Waliszewski S, Barradas Dermitz D, Orta Flores Z, Hayward Jones P, Nolasco Hipólito C, et al. The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plant Foods Hum Nutr. 2005;60:153-9 pubmed
    ..The object of the present study was to evaluate the effect of Hibiscus sabdariffa L. dried calyx ethanolic extract on the serum lipid profile of Sprague-Dawley rats...
  52. Li W, Wong S. Analyses of subgenomic promoters of Hibiscus chlorotic ringspot virus and demonstration of 5' untranslated region and 3'-terminal sequences functioning as subgenomic promoters. J Virol. 2006;80:3395-405 pubmed
    b>Hibiscus chlorotic ringspot virus (HCRSV), which belongs to the genus Carmovirus, generates two 3'-coterminal subgenomic RNAs (sgRNAs) of 1.4 kb and 1.7 kb...
  53. Lee W, Wang C, Chen Y, Hsu J, Cheng S, Chen H, et al. Polyphenol extracts from Hibiscus sabdariffa Linnaeus attenuate nephropathy in experimental type 1 diabetes. J Agric Food Chem. 2009;57:2206-10 pubmed publisher
    ..Oxidative stress is one of the precipitation factors in diabetic nephropathy. Previously, Hibiscus sabdariffa Linnaeus and its polyphenol extracts were found to possess antioxidative effects...
  54. Trivellini A, Ferrante A, Vernieri P, Serra G. Effects of abscisic acid on ethylene biosynthesis and perception in Hibiscus rosa-sinensis L. flower development. J Exp Bot. 2011;62:5437-52 pubmed publisher
    ..of the complex relationship between ethylene and abscisic acid (ABA) on flower development and senescence in Hibiscus rosa-sinensis L. was investigated...
  55. Liang X, Lucy A, Ding S, Wong S. The p23 protein of hibiscus chlorotic ringspot virus is indispensable for host-specific replication. J Virol. 2002;76:12312-9 pubmed
    b>Hibiscus chlorotic ringspot virus (HCRSV) possesses a novel open reading frame (ORF) which encodes a putative 23-kDa protein (p23). We report here the in vivo detection of p23 and demonstrate its essential role in viral replication...
  56. Lee Y, Byeon S, Kim J, Lee J, Rhee M, Hong S, et al. Immunomodulatory effect of Hibiscus cannabinus extract on macrophage functions. J Ethnopharmacol. 2007;113:62-71 pubmed
    b>Hibiscus cannabinus L. (Malvaceae) (known as Kenaf) has long been used as a folk medicine in India and Africa for the treatment of blood and throat disorders, bilious conditions, fever and puerperium...
  57. Mozaffari Khosravi H, Jalali Khanabadi B, Afkhami Ardekani M, Fatehi F, Noori Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Hum Hypertens. 2009;23:48-54 pubmed publisher
    To compare the antihypertensive effectiveness of sour tea (ST; Hibiscus sabdariffa) with black tea (BT) infusion in diabetic patients, this double-blind randomized controlled trial was carried out...
  58. Foyet H, Hritcu L, Ciobica A, Stefan M, Kamtchouing P, Cojocaru D. Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease. J Ethnopharmacol. 2011;133:773-9 pubmed publisher
    While the Hibiscus asper Hook.f...
  59. Tewary S, Oda T, Kendall A, Bian W, Stubbs G, Wong S, et al. Structure of hibiscus latent singapore virus by fiber diffraction: a nonconserved his122 contributes to coat protein stability. J Mol Biol. 2011;406:516-26 pubmed publisher
    b>Hibiscus latent Singapore virus (HLSV) is a rigid rod-shaped plant virus and a new member of the Tobamovirus family. Unlike all other Tobamoviruses, the HLSV genome contains a unique poly(A) tract in its 3' untranslated region...
  60. Holser R, Bost G, Van Boven M. Phytosterol composition of hybrid Hibiscus seed oils. J Agric Food Chem. 2004;52:2546-8 pubmed
    The seed oils from fifteen hybrid Hibiscus varieties were analyzed for desmethyl sterol content to identify bioactive compounds that could promote the use of these oils for edible applications...
  61. Marianthi T. Kenaf (Hibiscus cannabinus L.) core and rice hulls as components of container media for growing Pinus halepensis M. seedlings. Bioresour Technol. 2006;97:1631-9 pubmed
    ..The seedlings produced in the growth media containing kenaf did not attain a suitable planting size and showed poorer field performance than control seedlings...
  62. Tian Q, Sun D, Zhao M, Zhang W. Inhibition of nitric oxide synthase (NOS) underlies aluminum-induced inhibition of root elongation in Hibiscus moscheutos. New Phytol. 2007;174:322-31 pubmed
    ..Here, we investigated the role of NO in Al toxicity to Hibiscus moscheutos. Exposure of H...
  63. Lam S, Ng T. Novel galactonic acid-binding hexameric lectin from Hibiscus mutabilis seeds with antiproliferative and potent HIV-1 reverse transcriptase inhibitory activities. Acta Biochim Pol. 2009;56:649-54 pubmed
    A hexameric 150-kDa lectin was isolated from dried Hibiscus mutabilis seeds using a chromatographic protocol that involved ion exchange chromatography on SP-Sepharose, and gel filtration on Superdex 75 and Superdex 200...
  64. Mahmoud Y. Effect of extract of Hibiscus on the ultrastructure of the testis in adult mice. Acta Histochem. 2012;114:342-8 pubmed publisher
    b>Hibiscus sabdariffa extract is a popular beverage in many tropical and sub-tropical countries. Although, Hibiscus tea is known for its medicinal effects for thousands of years, scientific evidence of its systemic safety is very limited...
  65. Fernández Arroyo S, Herranz López M, Beltran Debon R, Borrás Linares I, Barrajón Catalán E, Joven J, et al. Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status. Mol Nutr Food Res. 2012;56:1590-5 pubmed publisher
    The aqueous extracts of Hibiscus sabdariffa have been commonly used in folk medicine. Nevertheless, the compounds or metabolites responsible for its healthy effects have not yet been identified...
  66. Chen C, Hsu J, Wang S, Chiang H, Yang M, Kao E, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem. 2003;51:5472-7 pubmed
    b>Hibiscus sabdariffa L., a local soft drink material and medicinal herb, is usually used effectively in native medicines against hypertension, pyrexia, and liver disorders. Here, we report an extract, HSE (H...
  67. Ouoba L, Parkouda C, Diawara B, Scotti C, Varnam A. Identification of Bacillus spp. from Bikalga, fermented seeds of Hibiscus sabdariffa: phenotypic and genotypic characterization. J Appl Microbiol. 2008;104:122-31 pubmed
    To identify Bacillus spp. responsible of the fermentation of Hibiscus sabdariffa for production of Bikalga, an alkaline fermented food used as a condiment in Burkina Faso.
  68. Yang G, Zhou R, Tang T, Shi S. Simple and efficient isolation of high-quality total RNA from Hibiscus tiliaceus, a mangrove associate and its relatives. Prep Biochem Biotechnol. 2008;38:257-64 pubmed publisher
    b>Hibiscus tiliaceus, one of the mangrove associates, is an ideal plant for the study of ecological adaptation and salt tolerance as it may give clues to the evolutionary pathway by which the highly specialized adaptive syndrome of mangrove ..
  69. Kao E, Hsu J, Wang C, Yang S, Cheng S, Lee H. Polyphenols extracted from Hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditions and regulating cyclooxygenase-2 expression. Biosci Biotechnol Biochem. 2009;73:385-90 pubmed
    Oxidative stress and inflammation are related to several chronic diseases including cancer and atherosclerosis. Hibiscus sabdariffa Linnaeus has been found to possess antioxidant effects...
  70. Saini P, Gayen P, Nayak A, Kumar D, Mukherjee N, Pal B, et al. Effect of ferulic acid from Hibiscus mutabilis on filarial parasite Setaria cervi: molecular and biochemical approaches. Parasitol Int. 2012;61:520-31 pubmed publisher
    In the reported work the in vitro activity of a methanolic extract of leaves of Hibiscus mutabilis (Malvaceae) against bovine Setaria cervi worms has been investigated...
  71. Hopkins A, Lamm M, Funk J, Ritenbaugh C. Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies. Fitoterapia. 2013;85:84-94 pubmed publisher
    The effectiveness of Hibiscus sabdariffa L...
  72. Villalpando Arteaga E, Mendieta Condado E, Esquivel Solís H, Canales Aguirre A, Galvez Gastelum F, Mateos Díaz J, et al. Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-? and SREBP-1c in diet-induced obese mice. Food Funct. 2013;4:618-26 pubmed publisher
    ..We investigated whether the aqueous extract of Hibiscus sabdariffa L...
  73. Liang X, Lee B, Wong S. Covariation in the capsid protein of hibiscus chlorotic ringspot virus induced by serial passaging in a host that restricts movement leads to avirulence in its systemic host. J Virol. 2002;76:12320-4 pubmed
    b>Hibiscus chlorotic ringspot virus (HCRSV) from naturally infected Hibiscus rosa-sinensis L. loses virulence in its experimental systemic host Hibiscus cannabinus L. (kenaf) after serial passages in a local lesion host Chenopodium quinoa...
  74. Pfeil B, Brubaker C, Craven L, Crisp M. Paralogy and orthology in the MALVACEAE rpb2 gene family: investigation of gene duplication in hibiscus. Mol Biol Evol. 2004;21:1428-37 pubmed
    ..b>Hibiscus and related taxa possess two rpb2 genes, both of which produce congruent phylogenetic patterns that are largely ..
  75. Zhou T, Fan Z, Li H, Wong S. Hibiscus chlorotic ringspot virus p27 and its isoforms affect symptom expression and potentiate virus movement in kenaf (Hibiscus cannabinus L.). Mol Plant Microbe Interact. 2006;19:948-57 pubmed
    b>Hibiscus chlorotic ringspot virus (HCRSV), a member of the genus Carmovirus, encodes p27 (27-kDa protein) and two other in-frame isoforms (p25 and p22.5) that are coterminal at the carboxyl end...
  76. Ajay M, Chai H, Mustafa A, Gilani A, Mustafa M. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol. 2007;109:388-93 pubmed
    Previous studies have demonstrated the anti-hypertensive effects of Hibiscus sabdariffa L. (HS) in both humans and experimental animals...
  77. Asagba S, Adaikpoh M, Kadiri H, Obi F. Influence of aqueous extract of Hibiscus sabdariffa L. petal on cadmium toxicity in rats. Biol Trace Elem Res. 2007;115:47-57 pubmed
    ..Cd) on some selected biochemical parameters, as well as the possible protective role of aqueous extracts of Hibiscus sabdariffa L petal were studied in 12-wk-old male Wistar albino rats...
  78. Fakeye T, Pal A, Bawankule D, Khanuja S. Immunomodulatory effect of extracts of Hibiscus sabdariffa L. (Family Malvaceae) in a mouse model. Phytother Res. 2008;22:664-8 pubmed publisher
    ..The insoluble fraction could find use as an immunostimulatory agent in humans...
  79. Paoletti E, Ferrara A, Calatayud V, Cerveró J, Giannetti F, Sanz M, et al. Deciduous shrubs for ozone bioindication: Hibiscus syriacus as an example. Environ Pollut. 2009;157:865-70 pubmed publisher
    Ozone-like visible injury was detected on Hibiscus syriacus plants used as ornamental hedges. Weekly spray of the antiozonant ethylenediurea (EDU, 300ppm) confirmed that the injury was induced by ambient ozone...
  80. Gonzalez Palomares S, Estarrón Espinosa M, Gómez Leyva J, Andrade González I. Effect of the temperature on the spray drying of Roselle extracts (Hibiscus sabdariffa L.). Plant Foods Hum Nutr. 2009;64:62-7 pubmed publisher
    The effect of the drying temperature on the volatile components and sensory acceptance of the Roselle (Hibiscus sabdariffa) extract in powder was investigated...
  81. Mozaffari Khosravi H, Jalali Khanabadi B, Afkhami Ardekani M, Fatehi F. Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes. J Altern Complement Med. 2009;15:899-903 pubmed publisher
    There is increasing evidence that intake of sour tea (Hibiscus sabdariffa) has hypoglycemic and hypolipidemic effects and may benefit patients suffering from metabolic disorders such as diabetes...
  82. Ravishankar S, Jaroni D, Zhu L, Olsen C, McHugh T, Friedman M. Inactivation of Listeria monocytogenes on ham and bologna using pectin-based apple, carrot, and hibiscus edible films containing carvacrol and cinnamaldehyde. J Food Sci. 2012;77:M377-82 pubmed publisher
    ..to investigate the antimicrobial effects of carvacrol and cinnamaldehyde, incorporated into apple, carrot, and hibiscus-based edible films against Listeria monocytogenes on contaminated ham and bologna...
  83. Wu P, Chuang T, He C, Wu T. Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis. Bioorg Med Chem. 2004;12:2193-7 pubmed
    The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), ..
  84. Hirunpanich V, Utaipat A, Morales N, Bunyapraphatsara N, Sato H, Herunsalee A, et al. Antioxidant effects of aqueous extracts from dried calyx of Hibiscus sabdariffa Linn. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biol Pharm Bull. 2005;28:481-4 pubmed
    The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL)...
  85. Ali B, Al Wabel N, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res. 2005;19:369-75 pubmed
    This article reviews the reported phytochemical, pharmacological and toxicological properties of Hibiscus sabdariffa L...
  86. Farombi E, Fakoya A. Free radical scavenging and antigenotoxic activities of natural phenolic compounds in dried flowers of Hibiscus sabdariffa L. Mol Nutr Food Res. 2005;49:1120-8 pubmed
    ..HSCF, chloroform soluble fraction and HSEA, ethyl acetate soluble fraction) obtained from the dried flowers of Hibiscus sabdariffa L were investigated. The total antioxidant activity of the extracts was estimated to be 4.6 and 8...
  87. Chang Y, Huang K, Huang A, Ho Y, Wang C. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem Toxicol. 2006;44:1015-23 pubmed
    ..As shown in previous studies Hibiscus sabdariffa L...
  88. Rosa R, Moura D, Melecchi M, dos Santos R, Richter M, Camarão E, et al. Protective effects of Hibiscus tiliaceus L. methanolic extract to V79 cells against cytotoxicity and genotoxicity induced by hydrogen peroxide and tert-butyl-hydroperoxide. Toxicol In Vitro. 2007;21:1442-52 pubmed
    Plants of the genus Hibiscus thrives produce a diversity of molecules with bioactive properties. In a previous study of Hibiscus tiliaceus L...
  89. Sáyago Ayerdi S, Arranz S, Serrano J, Goñi I. Dietary fiber content and associated antioxidant compounds in Roselle flower (Hibiscus sabdariffa L.) beverage. J Agric Food Chem. 2007;55:7886-90 pubmed
    The beverage of Hibiscus sabdariffa flowers is widely consumed in Mexico. Polyphenols contained in plant foods are frequently associated with dietary fiber...
  90. Kim J, So H, Youn M, Kim H, Kim Y, Park C, et al. Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharmacol. 2007;114:260-7 pubmed
    b>Hibiscus sabdariffa L., a tropical beverage material and medical herb, is used commonly as in folk medicines against hypertension, pyrexia, inflammation, liver disorders, and obesity...
  91. Prasongwatana V, Woottisin S, Sriboonlue P, Kukongviriyapan V. Uricosuric effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former subjects. J Ethnopharmacol. 2008;117:491-5 pubmed publisher
    The Roselle (Hibiscus sabdariffa) was investigated for its uricosuric effect.
  92. Mourtzinos I, Makris D, Yannakopoulou K, Kalogeropoulos N, Michali I, Karathanos V. Thermal stability of anthocyanin extract of Hibiscus sabdariffa L. in the presence of beta-cyclodextrin. J Agric Food Chem. 2008;56:10303-10 pubmed publisher
    The thermal stability of anthocyanin extract isolated from the dry calyces of Hibiscus sabdariffa L. was studied over the temperature range 60-90 degrees C in aqueous solutions in the presence or absence of beta-cyclodextrin (beta-CD)...