magnolia

Summary

Summary: A plant genus of the family MAGNOLIACEAE. The germacranolide sesquiterpene lactones costunolide, parthenolide, and costunolide diepoxide have been isolated from the leaves. Bark contains honokiol and magnolol. Parts are an ingredient of Banxia Houpo Tang.

Top Publications

  1. Li N, Song Y, Zhang W, Wang W, Chen J, Wong A, et al. Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Regul Toxicol Pharmacol. 2007;49:154-9 pubmed
    b>Magnolia bark extract (MBE) is an extract of the dried stem, root, or branch bark of magnolia trees that has been used historically in traditional Chinese and Japanese medicines, and more recently as a component of dietary supplements and ..
  2. Kim J, Kim J, Lee H, Lim H, Lee D, Kim D, et al. Suppression of inducible nitric oxide synthase expression by furfuran lignans from flower buds of Magnolia fargesii in BV-2 microglial cells. Phytother Res. 2010;24:748-53 pubmed publisher
    ..Three active lignans have been isolated from the flower buds of Magnolia fargesii by the bioassay-guided fractionation using lipopolysaccharide (LPS)-activated BV-2 microglial cell ..
  3. Mucci M, Carraro C, Mancino P, Monti M, Papadia L, Volpini G, et al. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. Minerva Ginecol. 2006;58:323-34 pubmed
    ..isoflavones (60 mg), lactobacilli (500 millions spores), calcium (141 mg) and vitamin D3 (5 microg) was added of Magnolia bark extract (60 mg) and magnesium (50 mg) (Estromineral serena, ES)...
  4. Ko C, Chen H, Lin Y, Chan M. Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea. Planta Med. 2003;69:532-6 pubmed
    Magnolol and honokiol are the two major phenolic constituents of the plant medicine "Houpo" ( Magnolia obovata), which is used in the treatment of chest tightness and asthma...
  5. Kong C, Lee J, Kim J, Seo Y. In vitro evaluation on the antiobesity effect of lignans from the flower buds of Magnolia denudata. J Agric Food Chem. 2011;59:5665-70 pubmed publisher
    ..study, an attempt has been made to isolate antiobesity components from crude extracts of the flower buds of Magnolia denudata by CH(2)Cl(2) and MeOH solvents...
  6. Chuang D, Chan M, Zong Y, Sheng W, He Y, Jiang J, et al. Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells. J Neuroinflammation. 2013;10:15 pubmed publisher
    The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders...
  7. Jackson C, Denney W. Annual and seasonal variation in the phyllosphere bacterial community associated with leaves of the southern Magnolia (Magnolia grandiflora). Microb Ecol. 2011;61:113-22 pubmed publisher
    ..We sampled replicate leaves from a single magnolia (Magnolia grandiflora) tree in the winter of three consecutive years (2007-2009) as well as during four seasons ..
  8. Han H, VAN Anh L. Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis. Anticancer Res. 2012;32:4445-52 pubmed
    ..The present study suggests that honokiol, magnolol and 4-O-methylhonokiol could be promising agents for reducing the multidrug resistance of cancer cells to anticancer drugs via the down-regulation of P-gp expression. ..
  9. Kalman D, Feldman S, Feldman R, Schwartz H, Krieger D, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008;7:11 pubmed publisher
    ..This study measured the effects of a proprietary blend of extracts of Magnolia officinalis and Phellodendron amurense (Relora) on anxiety, stress and sleep in healthy premenopausal women.

More Information

Publications77

  1. Koetter U, Barrett M, Lacher S, Abdelrahman A, Dolnick D. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009;124:421-5 pubmed publisher
    b>Magnolia officinalis Rehder and Wilson [Magnoliaceae] bark and Ziziphus spinosa (Buhge) Hu ex. Chen. [Fam. Rhamnaceae] seed have a history of use in traditional Asian medicine for mild anxiety, nervousness and sleep-related problems.
  2. Xu Q, Yi L, Pan Y, Wang X, Li Y, Li J, et al. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:715-25 pubmed
    Honokiol and magnolol are the main constituents simultaneously identified in the barks of Magnolia officinalis, which have been used in traditional Chinese medicine to treat a variety of mental disorders including depression...
  3. Wang Y, Li C, Lin I, Lee A, Hu M. Synthesis and radical scavenging of novel magnolol derivatives. J Pharm Pharmacol. 2002;54:1697-703 pubmed
    ..of potential antioxidants based on magnolol, a naturally occurring biphenolic obtained from the bark of Magnolia officinalis...
  4. Liu Z, Zhang X, Cui W, Zhang X, Li N, Chen J, et al. Evaluation of short-term and subchronic toxicity of magnolia bark extract in rats. Regul Toxicol Pharmacol. 2007;49:160-71 pubmed
    b>Magnolia bark has been traditionally used in Chinese and Japanese medicines, and its extract is a constituent of currently marketed dietary supplements and cosmetic products...
  5. Lee Y, Choi D, Han S, Kim Y, Kim K, Hwang B, et al. Inhibitory effect of ethanol extract of Magnolia officinalis on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's disease via regulating ?-secretase activity. Phytother Res. 2012;26:1884-92 pubmed publisher
    ..The components of the herb Magnolia officinalis are known to have antiinflammatory, antioxidative and neuroprotective activities...
  6. Seo J, Lee S, Lee Y, Kwon B, Ma Y, Hwang B, et al. Anxiolytic-like effects of obovatol isolated from Magnolia obovata: involvement of GABA/benzodiazepine receptors complex. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1363-9 pubmed
    This experiment was performed to investigate whether obovatol isolated from the leaves of Magnolia obovata has anxiolytic-like effects through GABA-benzodiazepine-receptors Cl(-) channel activation...
  7. Chang W, Yu Y, Hsu Y, Wu C, Yin P, Chiang S, et al. Inhibitory effect of Magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits. J Cardiovasc Pharmacol. 2006;47:463-8 pubmed
    ..Both lovastatin and Magnolia officinalis are hypocholesterolemic agents. Therefore, we investigated the effect of M...
  8. Lee S, Kim H, Cho Y, Park K, Kim E, Jung K, et al. Aqueous extract of Magnolia officinalis mediates proliferative capacity, p21WAF1 expression and TNF-alpha-induced NF-kappaB activity in human urinary bladder cancer 5637 cells; involvement of p38 MAP kinase. Oncol Rep. 2007;18:729-36 pubmed
    b>Magnolia officinalis is a commonly used herb in East Asian countries and has multiple pharmacological effects...
  9. Hoi C, Ho Y, Baum L, Chow A. Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells. Phytother Res. 2010;24:1538-42 pubmed publisher
    ..The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease...
  10. Kim H, Bae S, Kim D, Kim B, Lee S, Lee U, et al. Inhibitory role of magnolol on proliferative capacity and matrix metalloproteinase-9 expression in TNF-alpha-induced vascular smooth muscle cells. Int Immunopharmacol. 2007;7:1083-91 pubmed
    Magnolol, an active component extracted from Magnolia officinalis, has been reported to inhibit the development of atherosclerotic disease...
  11. Bajpai V, Yoon J, Kang S. Antioxidant and antidermatophytic activities of essential oil and extracts of Magnolia liliflora Desr. Food Chem Toxicol. 2009;47:2606-12 pubmed publisher
    ..was carried out to assess the antioxidant and antidermatophytic activities of the essential oil and extracts of Magnolia liliflora Desr. Antioxidant activity was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay...
  12. Lee Y, Choi I, Ban J, Lee H, Lee U, Han S, et al. 4-O-methylhonokiol attenuated ?-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase. J Nutr Biochem. 2011;22:476-86 pubmed publisher
    ..death and memory impairment, but pre-treatment of 4-O-methylhonokiol (4-O-MH), a novel compound extracted from Magnolia officinalis for 3 weeks (0.2, 0.5 and 1...
  13. Choi E. Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators. Int Immunopharmacol. 2011;11:1541-5 pubmed publisher
    ..Honokiol is a phenolic compound isolated from the bark of Magnolia officinalis, a plant widely used in traditional medicine...
  14. Kang J, Lee K, Han M, Lee H, Ahn J, Han S, et al. Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus. Phytother Res. 2008;22:883-8 pubmed publisher
    The present study reports the antiinflammatory activity of a methanol extract isolated from the stem bark of Magnolia kobus (MK)...
  15. Singh T, Katiyar S. Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2. Int J Oncol. 2011;38:769-76 pubmed publisher
    In the present study, we report the effects of honokiol, a phytochemical from Magnolia spp., on cancer cell migration capacity and the molecular mechanisms underlying these effects using breast cancer cell lines as an in vitro model...
  16. Lin S, Tsai S, Lee Chao P, Chen Y, Hou Y. Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats. Planta Med. 2011;77:1800-5 pubmed publisher
    Magnolol (M) is a polyphenol antioxidant abundant in the bark of Magnolia officinalis Rehder & E. Wilson, a popular Chinese herb...
  17. Walker J, Maitra A, Walker J, Ehrnhoefer Ressler M, Inui T, Somoza V. Identification of Magnolia officinalis L. bark extract as the most potent anti-inflammatory of four plant extracts. Am J Chin Med. 2013;41:531-44 pubmed publisher
    This study was designed to compare the anti-inflammatory potential of a Magnolia officinalis L. bark extract solely or in combination with extracts prepared from either Polygonum aviculare L., Sambucus nigra L., or Isodon japonicus L...
  18. Chang H, Lee S, Yang C, Chen I. Cytotoxic sesquiterpenes from Magnolia kachirachirai. Chem Biodivers. 2010;7:2737-47 pubmed publisher
    Bioassay-guided fractionation of the root wood of Magnolia kachirachirai (Kanehira & Yamamoto) Dandy (Magnoliaceae) led to the isolation of three new compounds, kachiraterpenol (1), (E)-2,3-bis(4-hydroxy-3-methoxyphenyl)prop-2-enal (..
  19. Chan S, Zhao M, Lao L, Fong H, Che C. Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum. Planta Med. 2008;74:381-4 pubmed publisher
    b>Magnolia officinalis is a commonly used traditional Chinese medicine for treating gastrointestinal disorders. HPLC quantification analysis revealed that magnolol and honokiol were the most abundant constituents of M...
  20. Chen C, Tan R, Qu W, Wu Z, Wang Y, Urade Y, et al. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice. Br J Pharmacol. 2011;164:1534-46 pubmed publisher
    ..The aim of this study was to evaluate the anti-convulsant effects of magnolol (6, 6', 7, 12-tetramethoxy-2, 2'-dimethyl-1-?-berbaman, C18H18O2) and the mechanisms involved...
  21. Hahm E, Arlotti J, Marynowski S, Singh S. Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction. Clin Cancer Res. 2008;14:1248-57 pubmed publisher
    This study was undertaken to determine the efficacy of honokiol, a constituent of oriental medicinal herb Magnolia officinalis, against human prostate cancer cells in culture and in vivo.
  22. Lee B, Doo H, Lee H, Jin S, Jung J, Hong S, et al. The inhibitory effects of aqueous extract of Magnolia officinalis on human mesangial cell proliferation by regulation of platelet-derived growth factor-BB and transforming growth factor-beta1 expression. J Pharmacol Sci. 2004;94:81-5 pubmed
    ..b>Magnolia officinalis, stem bark of Machilus thunbergii S., has multiple pharmacological effects...
  23. Li X, Gao H, Wang Y, Song J, Henry R, Wu H, et al. Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species. Sci China Life Sci. 2013;56:189-98 pubmed publisher
    b>Magnolia grandiflora is an important medicinal, ornamental and horticultural plant species. The chloroplast (cp) genome of M...
  24. Li X, Hu Z, Lin X, Li Q, Gao H, Luo G, et al. [High-throughput pyrosequencing of the complete chloroplast genome of Magnolia officinalis and its application in species identification]. Yao Xue Xue Bao. 2012;47:124-30 pubmed
    ..The complete chloroplast genome of Magnolia officinalis sequenced by high-throughput pyrosequencing and a sequencing procedure was established...
  25. Youn U, Chen Q, Lee I, Kim H, Yoo J, Lee J, et al. Two new lignans from the stem bark of Magnolia obovata and their cytotoxic activity. Chem Pharm Bull (Tokyo). 2008;56:115-7 pubmed
    Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13)...
  26. Hu Y, Qiao J, Zhang X, Ge C. Antimicrobial effect of Magnolia officinalis extract against Staphylococcus aureus. J Sci Food Agric. 2011;91:1050-6 pubmed publisher
    The antimicrobial effect of Magnolia officinalis extract (MOE) against Staphylococcus aureus was investigated in a minced mutton system and the mechanisms of its antimicrobial activity were studied by light microscopy, transmission ..
  27. Baek J, Lee Y, Lee C, Go H, Kim J, Seo J, et al. Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells. Nitric Oxide. 2009;20:122-8 pubmed publisher
    ..Epimagnolin and fargesin are compounds isolated from the ethanol extract of Magnoliae flos, the seed of the Magnolia plant and are used to treat nasal congestion, headache and sinusitis in Asian countries...
  28. Lee J, Lee Y, Lee B, Nam S, Lee S, Kim Y, et al. Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid. Pharmacol Biochem Behav. 2010;95:31-40 pubmed publisher
    The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M...
  29. Kuo W, Chung C, Hwang T, Chen J. Biphenyl-type neolignans from Magnolia officinalis and their anti-inflammatory activities. Phytochemistry. 2013;85:153-60 pubmed publisher
    ..The MeOH extract of the stem bark of Magnolia officinalis showed potent inhibitory effects on superoxide anion generation and elastase release by human ..
  30. Zhou H, Shin E, Guo L, Youn U, Bae K, Kang S, et al. Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation. Eur J Pharmacol. 2008;586:340-9 pubmed publisher
    The extracts or constituents from the bark of Magnolia (M.) obovata are known to have many pharmacological activities. 4-Methoxyhonokiol, a neolignan compound isolated from the stem bark of M...
  31. Lee Y, Lee Y, Lee C, Jung J, Han S, Hong J. Therapeutic applications of compounds in the Magnolia family. Pharmacol Ther. 2011;130:157-76 pubmed publisher
    The bark and/or seed cones of the Magnolia tree have been used in traditional herbal medicines in Korea, China and Japan...
  32. Setsuko S, Ishida K, Tomaru N. Size distribution and genetic structure in relation to clonal growth within a population of Magnolia tomentosa Thunb. (Magnoliaceae). Mol Ecol. 2004;13:2645-53 pubmed
    To establish a baseline for conservation of a threatened clonal tree, Magnolia tomentosa, we investigated size distribution and genetic structure within a population, using six microsatellite markers...
  33. Vaid M, Sharma S, Katiyar S. Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation. Carcinogenesis. 2010;31:2004-11 pubmed publisher
    ..effective chemopreventive agents for skin cancer, we assessed the effect of honokiol, a phytochemical from the Magnolia plant, on ultraviolet (UV) radiation-induced skin tumorigenesis using the SKH-1 hairless mouse model...
  34. Tanaka K, Hasegawa J, Asamitsu K, Okamoto T. Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB. Eur J Pharmacol. 2007;565:212-9 pubmed
    ..In this study, we found that Magnolia ovovata extract inhibited NF-kappaB-mediated gene expression and demonstrated that external swabbing with ..
  35. Huang H, Hsieh W, Niu Y, Chang T. Inhibition of melanogenesis and antioxidant properties of Magnolia grandiflora L. flower extract. BMC Complement Altern Med. 2012;12:72 pubmed publisher
    b>Magnolia grandiflora L. flower is wildly used in Asian as a traditional herbal medication. The purpose of the study was to investigate the antimelanogenic and antioxidant properties of Magnolia grandiflora L. flower extract...
  36. Tamaki I, Ishida K, Setsuko S, Tomaru N. Interpopulation variation in mating system and late-stage inbreeding depression in Magnolia stellata. Mol Ecol. 2009;18:2365-74 pubmed publisher
    ..We investigated the mating system and late-stage inbreeding depression (delta) in 10 populations of Magnolia stellata using nine microsatellite markers and evaluated the effects of population size and the degree of ..
  37. Battle T, Arbiser J, Frank D. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood. 2005;106:690-7 pubmed
    ..These data indicate that honokiol is a potent inducer of apoptosis in B-CLL cells and should be examined for further clinical application either as a single agent or in combination with other anticancer agents...
  38. Feltenstein M, Schühly W, Warnick J, Fischer N, Sufka K. Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot. Pharmacol Biochem Behav. 2004;79:299-302 pubmed
    ..Two plants native to the southeastern United States, Magnolia grandiflora (L.) and Smallanthus uvedalius (L.) [syn Polymnia uvedalius (L...
  39. Ma L, Chen J, Wang X, Liang X, Luo Y, Zhu W, et al. Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. J Med Chem. 2011;54:6469-81 pubmed publisher
    ..The antiangiogenic effect and antiproliferative activity of these structurally modified honokiol analogues and derivatives have led to the establishment of a structure-activity relationship...
  40. Jacobo Salcedo M, Gonzalez Espindola L, Alonso Castro A, Gonzalez Martinez M, Dominguez F, Garcia Carranca A. Antimicrobial activity and cytotoxic effects of Magnolia dealbata and its active compounds. Nat Prod Commun. 2011;6:1121-4 pubmed
    ..Several Magnolia (Magnoliaceae) species have been reported to exert antimicrobial effects on sensitive and multidrug-resistant ..
  41. Dinis A, Coutinho A. Interaction of lipid bodies with other cell organelles in the maturing pollen of Magnolia x soulangeana (Magnoliaceae). Protoplasma. 2009;238:35-46 pubmed publisher
    The pollen grain maturation in Magnolia x soulangeana was studied ultrastructurally and cytochemically using both the light and transmission electron microscope...
  42. Liu L, Wu X, Fan L, Chen X, Hu Z. Separation and determination of honokiol and magnolol in herbal medicines by flow injection-capillary electrophoresis. Anal Bioanal Chem. 2006;384:1533-9 pubmed
    A simple, rapid, and accurate method for the separation and determination of honokiol and magnolol in Magnolia officinalis and related herbal medicines was developed by combination of flow injection (FI) and capillary zone electrophoresis ..
  43. Lee Y, Yuk D, Kim T, Kim Y, Kim K, Kim K, et al. Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity. J Nat Med. 2009;63:274-82 pubmed publisher
    Magnolol, honokiol, and obovatol are well-known bioactive constituents of the bark of Magnolia officinalis and have been used as traditional Chinese medicines for the treatment of neurosis, anxiety, and stroke...
  44. Kuang D, Wu H, Wang Y, Gao L, Zhang S, Lu L. Complete chloroplast genome sequence of Magnolia kwangsiensis (Magnoliaceae): implication for DNA barcoding and population genetics. Genome. 2011;54:663-73 pubmed publisher
    ..The plastome of Magnolia kwangsiensis Figlar & Noot...
  45. Kim J, Lim H, Lee D, Kim J, Kim D, Lee H, et al. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorg Med Chem Lett. 2009;19:937-40 pubmed publisher
    ..1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia...
  46. Kassuya C, Cremoneze A, Barros L, Simas A, Lapa F, Mello Silva R, et al. Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). J Ethnopharmacol. 2009;124:369-76 pubmed publisher
    b>Magnolia ovata (A.St.-Hil.) Spreng (formerly Talauma ovata), known as "pinha-do-brejo" or "baguaçu", is a large tree widely distributed in Brazil. Its trunk bark has been used in folk medicine against fever...
  47. Garrison R, Chambliss W. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006;12:50-4 pubmed
    To determine the efficacy of a dietary supplement ingredient containing proprietary extracts of Magnolia officinalis and Phellodendron amurense in helping overweight, otherwise healthy, premenopausal female adults, who typically eat more ..
  48. Lee S, Cho Y, Park K, Kim E, Kang B, Jung K, et al. Inhibitory effects of the aqueous extract of Magnolia officinalis on the responses of human urinary bladder cancer 5637 cells in vitro and mouse urinary bladder tumors induced by N-Butyl-N-(4-hydroxybutyl) nitrosamine in vivo. Phytother Res. 2009;23:20-7 pubmed publisher
    This study investigated the anticancer activity of Magnolia officinalis on urinary bladder cancer in vitro and in vivo, and elucidated the mechanism of its activity. An aqueous extract of M...
  49. Nakazawa T, Yasuda T, Ohsawa K. Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice. J Pharm Pharmacol. 2003;55:1583-91 pubmed
    As a part of our search for the active metabolite from the bark of Magnolia officinalis (Magnoliaceae), the aqueous extract was orally administered to rats, and metabolites in the urine were analysed by a high-performance liquid ..
  50. Yang S, Hsieh M, Tsai T, Hsu S. Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. Br J Pharmacol. 2003;138:193-201 pubmed
    1 Magnolol, an active component isolated from the root and stem bark of Magnolia officinalis, has been reported to exhibit antitumour effects, but little is known about its molecular mechanisms of action...
  51. Oh J, Kang L, Ban J, Kim Y, Kim K, Han S, et al. Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected]. Chem Biol Interact. 2009;180:506-14 pubmed publisher
    The bioactive constituents isolated from the bark of Magnolia officinalis such as magnolol, honokiol and obovatol have anti-inflammatory properties through the inactivation of NF-kappaB which is an important factor in the regulation of ..
  52. Shen C, Ni C, Shen Y, Huang Y, Kuo C, Wu T, et al. Phenolic constituents from the stem bark of Magnolia officinalis. J Nat Prod. 2009;72:168-71 pubmed publisher
    ..syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2-8b were studied for anti-inflammatory and antioxidative activities...
  53. Shen Y, Li C, Zhou S, Pang E, Story D, Xue C. Chemistry and bioactivity of Flos Magnoliae, a Chinese herb for rhinitis and sinusitis. Curr Med Chem. 2008;15:1616-27 pubmed
    ..A small number of water-soluble compounds have been isolated from Magnolia flower buds, including a benzylisoquinoline alkaloid magnoflorine, an ester ethyl-E-p-hydroxyl-cinnamate and a ..
  54. Wu X, Yu C, Cai W, Hua J, Li S, Wang W. Protective effect of a polyphenolic rich extract from Magnolia officinalis bark on influenza virus-induced pneumonia in mice. J Ethnopharmacol. 2011;134:191-4 pubmed publisher
    b>Magnolia officinalis bark is used in traditional Chinese medicine for the treatment of cough, colds, fever, chronic bronchitis and stomach ailments.
  55. Youn U, Chen Q, Jin W, Lee I, Kim H, Lee J, et al. Cytotoxic lignans from the stem bark of Magnolia officinalis. J Nat Prod. 2007;70:1687-9 pubmed
    ..2), and 4'-methoxymagnaldehyde E ( 3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds ( 4- 11)...
  56. Chen C, Zhou X, Luo Y, Huang Z, Urade Y, Qu W. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Neuropharmacology. 2012;63:1191-9 pubmed publisher
    ..6,6',7,12-tetramethoxy-2,2'-dimethyl-1-beta-berbaman, C(18)H(18)O(2)), an active ingredient of the bark of Magnolia officinalis, has been reported to exert potent anti-epileptic effects via the GABA(A) receptor...
  57. Syu W, Shen C, Lu J, Lee G, Sun C. Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis. Chem Biodivers. 2004;1:530-7 pubmed
    ..enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA), the medicinal plant Magnolia officinalis was subjected to bioassay-directed fractionation, which led to the isolation of the known neolignans ..
  58. Pyo M, Lee Y, Yun Choi H. Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata. Arch Pharm Res. 2002;25:325-8 pubmed
    ..obovatol, methyl caffeate, and syringin, were isolated from the methanol extracts of the barks and fruits of Magnolia obovata. The compounds were identified based on the spectroscopic data...
  59. Alonso Castro A, Zapata Bustos R, Dominguez F, Garcia Carranca A, Salazar Olivo L. Magnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathway. Phytomedicine. 2011;18:926-33 pubmed publisher
    Some Magnolia (Magnoliaceae) species are used for the empirical treatment of diabetes mellitus, but the antidiabetic properties of Magnolia dealbata have not yet been experimentally validated...
  60. Shih H, Hwang T, Chen H, Kuo P, Lee E, Lee K, et al. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release. PLoS ONE. 2013;8:e59502 pubmed publisher
    ..houpulins C and D (3 and 4), were isolated and characterized from an ethanol extract obtained from the roots of Magnolia officinalis...
  61. Bai X, Cerimele F, Ushio Fukai M, Waqas M, Campbell P, Govindarajan B, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003;278:35501-7 pubmed
    ..Aqueous extracts of Magnolia grandiflora exhibit potent activity in our SVR proliferation assays...
  62. Martinez A, Dominguez F, Orozco S, Chavez M, Salgado H, Gonzalez M, et al. Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. J Ethnopharmacol. 2006;106:250-5 pubmed
    b>Magnolia dealbata Zucc. is considered to have tranquilizer and anticonvulsant properties in Mexican traditional medicine...
  63. Wu Y, Lin L, Tsai T. Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection. Biomed Chromatogr. 2006;20:1076-81 pubmed
    ..spectrometric detection (LC-MS/MS) was developed for the simultaneous determination of honokiol and magnolol in Magnolia officinalis...
  64. Hepburn N, Schmidt D, Mower J. Loss of two introns from the Magnolia tripetala mitochondrial cox2 gene implicates horizontal gene transfer and gene conversion as a novel mechanism of intron loss. Mol Biol Evol. 2012;29:3111-20 pubmed
    ..chain reaction (PCR)-based assay to detect recent intron losses from the mitochondrial cox2 gene within genus Magnolia, which was previously suggested to have variability in cox2 intron content...
  65. Lee S, Chappell J. Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora. Plant Physiol. 2008;147:1017-33 pubmed publisher
    b>Magnolia grandiflora (Southern Magnolia) is a primitive evergreen tree that has attracted attention because of its horticultural distinctiveness, the wealth of natural products associated with it, and its evolutionary position as a basal ..
  66. He J, Chen L, Si Y, Huang B, Ban X, Wang Y. Population structure and genetic diversity distribution in wild and cultivated populations of the traditional Chinese medicinal plant Magnolia officinalis subsp. biloba (Magnoliaceae). Genetica. 2009;135:233-43 pubmed publisher
    b>Magnolia officinalis subsp. biloba, a traditional Chinese medicinal plant, experienced severe declines in the number of populations and the number of individuals in the late 20th century due to the widespread harvest of the subspecies...
  67. Yu S, Yan R, Liang R, Wang W, Yang B. Bioactive polar compounds from stem bark of Magnolia officinalis. Fitoterapia. 2012;83:356-61 pubmed publisher
    ..together with nine known compounds, were isolated from the polar part of methanol extract of the stem bark of Magnolia officinalis. The structures of the new compounds were established on the basis of spectral analysis...
  68. Schühly W, Khan S, Fischer N. Neolignans from North American Magnolia species with cyclooxygenase 2 inhibitory activity. Inflammopharmacology. 2009;17:106-10 pubmed publisher
    Based upon reported ethnomedicinal use by Native Americans, extracts and pure isolates from leaves and seeds of Magnolia grandiflora, M. virginiana, M. acuminata and M...