scrophularia

Summary

Summary: A plant genus of the family SCROPHULARIACEAE. Members contain iridoids.

Top Publications

  1. Kim S, Koo K, Sung S, Ma C, Yoon J, Kim Y. Iridoids from Scrophularia buergeriana attenuate glutamate-induced neurotoxicity in rat cortical cultures. J Neurosci Res. 2003;74:948-55 pubmed
    In previous work, we isolated 7 neuroprotective iridoid glycosides from the 90% MeOH fraction of Scrophularia buergeriana (Scrophulariaceae)...
  2. Jeong E, Lee K, Kim S, Sung S, Kim Y. Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice. Eur J Pharmacol. 2008;588:78-84 pubmed publisher
    The cognitive-enhancing activities of E-harpagoside and 8-O-E-p-methoxycinnamoylharpagide (MCA-Hg) isolated from Scrophularia buergeriana were evaluated in scopolamine-induced amnesic mice by the Morris water maze and by passive avoidance ..
  3. Jing J, Chan C, Xu L, Jin D, Cao X, Mok D, et al. Development of an in-line HPLC fingerprint ion-trap mass spectrometric method for identification and quality control of Radix Scrophulariae. J Pharm Biomed Anal. 2011;56:830-5 pubmed publisher
    ..The results indicated that the newly developed HPLC-DAD-MS fingerprint method would be suitable for quality control of Radix Scrophulariae...
  4. Ahmed B, Al Rehaily A, Al Howiriny T, El Sayed K, Ahmad M. Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity. Biol Pharm Bull. 2003;26:462-7 pubmed
    ..the two new compounds scropolioside-D(2) (1) and harpagoside-B (2), were isolated from the aerial parts of Scrophularia deserti DEL (Scrophulariaceae)...
  5. Yang S, Chen C, Zhao Y, Xi W, Zhou X, Chen B, et al. Association between chemical and genetic variation of wild and cultivated populations of Scrophularia ningpoensis Hemsl. Planta Med. 2011;77:865-71 pubmed publisher
    b>Scrophularia ningpoensis Hemsl. is an important Chinese medicinal herb with a domestication history of more than one thousand years...
  6. Giessrigl B, Yazici G, Teichmann M, Kopf S, Ghassemi S, Atanasov A, et al. Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers. Int J Oncol. 2012;40:2063-74 pubmed publisher
    Different studies describe the anti-inflammatory effects of Scrophularia species, a medicinal plant widely used in folk medicine since ancient times...
  7. Stavri M, Mathew K, Gibbons S. Antimicrobial constituents of Scrophularia deserti. Phytochemistry. 2006;67:1530-3 pubmed
    A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(zeta)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1)...
  8. Nguyen A, Fontaine J, Malonne H, Claeys M, Luhmer M, Duez P. A sugar ester and an iridoid glycoside from Scrophularia ningpoensis. Phytochemistry. 2005;66:1186-91 pubmed
    From cytotoxic extracts of the roots of Scrophularia ningpoensis Hemsl...
  9. Díaz A, Abad M, Fernández L, Silván A, De Santos J, Bermejo P. Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. Life Sci. 2004;74:2515-26 pubmed
    Five phenylpropanoid glycosides isolated from Scrophularia scorodonia L...

More Information

Publications95

  1. Ramunno A, Serrilli A, Piccioni F, Serafini M, Ballero M. Taxonomical markers in two endemic plants of Sardinia: Verbascum conocarpum and Scrophularia trifoliata. Nat Prod Res. 2006;20:511-6 pubmed
    The monoterpenoid composition of Verbascum conocarpum and Scrophularia trifoliata, both endemic plants of Sardinia, was examined...
  2. Valtueña F, Ortega Olivencia A, Rodríguez Riaño T, Pérez Bote J, Mayo C. Behaviour of pollinator insects within inflorescences of Scrophularia species from Iberian Peninsula. Plant Biol (Stuttg). 2013;15:328-34 pubmed publisher
    ..We here analyse behaviour of the principal pollinator groups in five protogynous species of Scrophularia with different flower sizes (S. sambucifolia, S. grandiflora, S. lyrata, S. scorodonia and S...
  3. Lai C, Lin H, Nalawade S, Fang W, Tsay H. Hyperhydricity in shoot cultures of Scrophularia yoshimurae can be effectively reduced by ventilation of culture vessels. J Plant Physiol. 2005;162:355-61 pubmed
    An effective procedure for obtaining healthy shoots from nodal segments of Scrophularia yoshimurae is described. Nodal segments cultured on Murashige and Skoog's (MS) basal medium supplemented with 1.0 mg L(-1) benzyladenine (BA) and 0...
  4. Tasdemir D, Güner N, Perozzo R, Brun R, Donmez A, Calis I, et al. Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots. Phytochemistry. 2005;66:355-62 pubmed
    The ethanolic root extract of Scrophularia lepidota, an endemic plant of the Turkish flora, has been investigated for its anti-protozoal and inhibitory effect towards plasmodial enoyl-ACP reductase (FabI), a key enzyme of fatty acid ..
  5. Baradaran P, Mohammadi A, Mansoori B, Baradaran S, Baradaran B. Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Biomed Pharmacother. 2017;85:718-724 pubmed publisher
    ..In the present study, we determine the effect of Scrophularia oxysepala on triggering apoptosis and diminishing growth, size and weight of the tumor in the allograft model ..
  6. Goldar S, Baradaran B, Shekari Khaniani M, Azadmehr A, Derakhshan S, Mohammadi A, et al. Extracts of Scrophularia frigida Boiss display potent antitumor effects in human breast cancer cells by inducing apoptosis and inhibition of expression of the human epidermal growth factor receptor 2. Cell Mol Biol (Noisy-le-grand). 2016;62:83-89 pubmed
    Some species of the Scrophularia genus have been extensively used as a natural remedy for treatment of various medical conditions...
  7. Zhu T, Zhang L, Ling S, Qian F, Li Y, Xu J. Anti-Inflammatory Activity Comparison among Scropoliosides-Catalpol Derivatives with 6-O-Substituted Cinnamyl Moieties. Molecules. 2015;20:19823-36 pubmed publisher
    ..Various scropoliosides were extracted, isolated, and purified from Scrophularia dentata Royle ex Benth...
  8. Baden C, Franke S, Dobler S. Host dependent iridoid glycoside sequestration patterns in Cionus hortulanus. J Chem Ecol. 2013;39:1112-4 pubmed publisher
    ..Curculionidae, Mecininae) sequester the iridoid glycosides (IGs) aucubin and catalpol from their host plants Scrophularia or Verbascum (Scrophulariaceae)...
  9. Kim S, Lee K, Koo K, Sung S, Lee N, Kim J, et al. Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots. J Nat Prod. 2002;65:1696-9 pubmed
    Four new iridoid glycosides were isolated from a 90% MeOH extract of Scrophularia buergeriana roots and characterized as 8-O-E-p-methoxycinnamoylharpagide (1), 8-O-Z-p-methoxycinnamoylharpagide (2), 6'-O-E-p-methoxycinnamoylharpagide (3), ..
  10. Jian W, Yu S, Tang M, Duan H, Huang J. A combination of the main constituents of Fufang Xueshuantong Capsules shows protective effects against streptozotocin-induced retinal lesions in rats. J Ethnopharmacol. 2016;182:50-6 pubmed publisher
    ..H. Chen, Salvia miltiorrhiza Bunge, Astragalus membranaceus (Fisch.) Bunge, and Scrophularia ningpoensis Hemsl, has proven effective for the treatment of diabetic retinopathy...
  11. Venditti A, Frezza C, Riccardelli M, Foddai S, Nicoletti M, Serafini M, et al. Secondary metabolites from Scrophularia canina L. Nat Prod Res. 2016;30:1665-9 pubmed publisher
    A re-examination of Scrophularia canina L...
  12. Li J, Ding X, Zhang R, Jiang W, Sun X, Xia Z, et al. Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways. Neuroscience. 2015;303:103-14 pubmed publisher
    ..the effect of Harpagoside (abbreviated HAR), an iridoid glycosides purified from the Chinese medicinal herb Scrophularia ningpoensis, on neurodegeneration induced by β-amyloid peptide (Aβ) and the underlying molecular ..
  13. Andersson P, Ehrlén J, Hambäck P. Plant patch structure influences plant fitness via antagonistic and mutualistic interactions but in different directions. Oecologia. 2016;180:1175-82 pubmed publisher
    ..and pollen limitation on plant reproductive performance in 28 patches of the self-compatible perennial herb Scrophularia nodosa and assessed how such effects varied with plant patch size, plant density and tree cover...
  14. Sukhtezari S, Almasi H, Pirsa S, Zandi M, Pirouzifard M. Development of bacterial cellulose based slow-release active films by incorporation of Scrophularia striata Boiss. extract. Carbohydr Polym. 2017;156:340-350 pubmed publisher
    Novel bacterial cellulose (BC) based monolayer and multilayer films, incorporating 5wt.% Scrophularia striata Boiss. extract (SE) were obtained...
  15. Yu H, Zhong M, Ding R, Song T, Yoshimitsu M, Xu X, et al. [A quantitative method for simultaneous assay of seven active ingredients with one marker in Scrophularia ningpoensis root]. Zhongguo Zhong Yao Za Zhi. 2017;42:2719-2724 pubmed publisher
    To establish a new quantitative method for simultaneous determination of multi-components in Scrophularia root by using high performance liquid chromatography (HPLC) and validate its feasibilities?Meanwhile,using catalpol as one chemical ..
  16. Sohn S, Ko E, Jeon S, Lee B, Kim S, Dong M, et al. The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells. Neurotoxicology. 2009;30:368-76 pubmed publisher
    ..This study was conducted to evaluate the protective mechanisms of Scrophularia ningpoensis (SN) extracts and chemicals on TG-stimulated U-87MG cells...
  17. Ahmad M, Muhammad N, Mehjabeen -, Jahan N, Alam S, Ahmad M, et al. Biological screening of Scrophularia nodosa extract and its fractions. Pak J Pharm Sci. 2012;25:307-13 pubmed
    Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities...
  18. Ma Q, Han L, Mu Y, Guan P, Lei H, Wang Z, et al. New Iridoids from Scrophularia ningpoensis. Chem Pharm Bull (Tokyo). 2017;65:869-873 pubmed publisher
    Five new compounds including five iridoids (1-5) and six known compounds were isolated from the rhizomes of Scrophularia ningpoensis. Their structures were determined by extensive NMR and IR, MS spectroscopic data analyses...
  19. Valtueña F, Rodríguez Riaño T, Lopez J, Mayo C, Ortega Olivencia A. Peripatric speciation in an endemic Macaronesian plant after recent divergence from a widespread relative. PLoS ONE. 2017;12:e0178459 pubmed publisher
    The Macaronesian Scrophularia lowei is hypothesized to have arisen from the widespread S. arguta on the basis of several phylogenetic studies of the genus, but sampling has been limited...
  20. Pasdaran A, Hamedi A. The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity. Pharm Biol. 2017;55:2211-2233 pubmed publisher
    b>Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction.
  21. Chen C, Chen C, Wu X, Wang R, Li Y. [Effects of extracts of Radix Scrophulariae on blood pressure in spontaneously hypertensive rats and the underlying mechanisms]. Zhong Xi Yi Jie He Xue Bao. 2012;10:1009-17 pubmed
    ..ERS possesses beneficial effects in inhibiting hypertension and attenuating arteriosclerosis. The underlying mechanism may be associated with restraining the release of vasoconstrictors, such as NA, Ang II, ET-1 and TXB(2). ..
  22. Wu X, Song X, Yang H, Liu F, Zhang X, Liu J, et al. [Identification and phylogenetic analysis of endophytic fungi isolated from Scrophularia ningpoensis]. Zhongguo Zhong Yao Za Zhi. 2017;42:902-911 pubmed publisher
    The endophytic fungi from root, main stem, branch and leaf of Scrophularia ningpoensis were isolated and identified from Wulong and Chongqing, and the population diversity analysis and phylogenetic analysis were followed...
  23. Wang Y, Liang Z, Li Q, Yang H, Chen H, Zhao Z, et al. Identification of powdered Chinese herbal medicines by fluorescence microscopy, Part 1: Fluorescent characteristics of mechanical tissues, conducting tissues, and ergastic substances. Microsc Res Tech. 2011;74:269-80 pubmed publisher
    ..Hence, fluorescence microscopy could be a useful additional method for the authentication of powdered CHMs if the fluorescent characteristics of specific CHMs are known...
  24. Xie L, Wang J, Liu H, Cai S. [Establishment of a TLC identification method for xuanshen(radix scrophulariae)]. Zhongguo Zhong Yao Za Zhi. 2000;25:654-6 pubmed
    ..The specificity of the method has been proved by a comparative detection of Xuanshen from different habitats and several crude drugs which are easily confused with Xuanshen. The method is simple, accurate and reliable. ..
  25. Niu Z, Wang R, Shang M, Cai S. A new iridoid glycoside from Scrophularia ningpoensis. Nat Prod Res. 2009;23:1181-8 pubmed publisher
    A new iridoid glycoside, named 6'-O-cinnamoylharpagide (1), has been isolated from the roots of Scrophularia ningpoensis (Scrophulariaceae) together with nine known compounds, harpagide (2), harpagoside (3), 8-O-feruloylharpagide (4), 8-O-..
  26. Lange I, Moschny J, Tamanyan K, Khutsishvili M, Atha D, Borris R, et al. Scrophularia orientalis extract induces calcium signaling and apoptosis in neuroblastoma cells. Int J Oncol. 2016;48:1608-16 pubmed publisher
    ..The current study examined the anticancer effects of a dichloromethane extract from Scrophularia orientalis L. (Scrophulariaceae), a plant that has been used in Traditional Chinese Medicine...
  27. Ortega Olivencia A, Rodríguez Riaño T, Pérez Bote J, Lopez J, Mayo C, Valtueña F, et al. Insects, birds and lizards as pollinators of the largest-flowered Scrophularia of Europe and Macaronesia. Ann Bot. 2012;109:153-67 pubmed publisher
    It has traditionally been considered that the flowers of Scrophularia are mainly pollinated by wasps. We studied the pollination system of four species which stand out for their large and showy flowers: S. sambucifolia and S...
  28. He D, Chen Y, Yang S, Zhang X, Zhao J, Mo J, et al. [Antifungal effects of three medicinal crops on Phytophthora nicotianae]. Zhongguo Zhong Yao Za Zhi. 2017;42:3509-3515 pubmed publisher
    ..investigate the antifungal effects of extracts from stem-leaf and root, root exudates, and their combination of Scrophularia ningpoensis, Chuanmingshen violaceum and Pinellia ternata The results showed that: ?Stem-leaf and root extracts ..
  29. Gu W, Chen C, Wang Y. [Comparative study of Scrophulariae and Aconite in inhibiting myocardial hypertrophy in rats and mice]. Zhong Xi Yi Jie He Xue Bao. 2008;6:376-80 pubmed publisher
    ..The inhibition of Aconite of hot nature on cardiac hypertrophy is not significant. ..
  30. Ahmad M, Muhammad N, Mehjabeen -, Jahan N, Ahmad M, Obaidullah -, et al. Spasmolytic effects of Scrophularia nodosa extract on isolated rabbit intestine. Pak J Pharm Sci. 2012;25:267-75 pubmed
    b>Scrophularia nodosa (figwort), an indigenous medicinal plant grows in moist and cultivated waste ground. It contains saponins, cardioactive glycosides, flavonoids, resin, sugar and organic acids...
  31. Calis I, Sezgin Y, Donmez A, Rüedi P, Tasdemir D. Crypthophilic acids A, B, and C: resin glycosides from aerial parts of Scrophularia crypthophila. J Nat Prod. 2007;70:43-7 pubmed
    The water-soluble part of the methanolic extract from the aerial parts of Scrophularia crypthophila, through chromatographic methods, yielded three new resin glycosides, crypthophilic acids A - C (1-3)...
  32. Kamada T, Yamashiro T, Maki M. Intraspecific morphological and genetic differentiation in Scrophularia grayana (Scrophulariaceae). J Plant Res. 2007;120:437-43 pubmed
    b>Scrophularia grayana, which is distributed throughout northern Japan and Sakhalin, and its locally endemic variety var. grayanoides, have been examined morphometrically and genetically...
  33. Lee M, Choi O, Park J, Cho H, Ahn M, Kim S, et al. Simultaneous determination of four active constituents in the roots of Scrophularia buergeriana by HPLC-DAD and LC-ESI-MS. J Sep Sci. 2007;30:2345-50 pubmed
    ..HG), E-cinnamic acid (CA), and E-p-methoxycinnamic acid (MCA), in the extract of Scrophularia buergeriana was studied using HPLC-diode array detector-electrospray-MS (HPLC-DAD-ESI-MS)...
  34. Niu Z, Wang R, Jing Y, Shang M, Cai S. [Study on preparation and quantity determination of Scrophularia ningpoensis dispensing granules]. Zhongguo Zhong Yao Za Zhi. 2009;34:39-42 pubmed
    To develop the preparation method and to determine the quantity of effective constituents of Scrophularia ningpoensis dispensing granules. Nine experiments were carried out through L9 (3(4)) orthogonal design...
  35. Kim S, Kang S, Lee K, Kim S, Markelonis G, Oh T, et al. Anti-amnestic activity of E-p-methoxycinnamic acid from Scrophularia buergeriana. Brain Res Cogn Brain Res. 2003;17:454-61 pubmed
    We previously reported that phenylpropanoids isolated from the roots of Scrophularia buergeriana Miquel (Scrophulariaceae) protected cultured cortical neurons against glutamate-induced neurotoxicity [Kim and Kim, Phytochemistry, 54 (2000) ..
  36. Shin H, Medriano C, Park B, Park Y, Lee K. Screening and identification of neuroprotective compounds from Scrophularia buergeriana using cell extraction coupled with LC-MS. J Pharm Biomed Anal. 2018;148:355-360 pubmed publisher
    ..The extracts and major compounds (phenylpropanoids and iridoid glycosides) of Scrophularia buergeriana Miquel have been reported to show neuroprotective effects both in vitro and in vivo...
  37. Qiu Q, Cen F, Zhen H. [Study on chemical constituents of petroleum ether portion from seed of Picria felterrae]. Zhong Yao Cai. 2013;36:230-2 pubmed
    ..Compounds I, II and IV are isolated from this plant for the first time. ..
  38. Xie W, Shao N, Ma X, Ding Q, Zhao X, Liu N, et al. [Study on serum proteome of rat endotoxemia treated by figwort root]. Zhongguo Zhong Yao Za Zhi. 2004;29:877-82 pubmed
    ..To study the serum proteome of rat endotoxemia treated by figwort root (FR)...
  39. Hajiaghaee R, Monsef Esfahani H, Khorramizadeh M, Saadat F, Shahverdi A, Attar F. Inhibitory effect of aerial parts of Scrophularia striata on matrix metalloproteinases expression. Phytother Res. 2007;21:1127-9 pubmed
    ..The aim of the present research was to verify the effects of a total extract and sequential extracts of Scrophularia striata Boiss (Scrophulariaceae) on MMPs activity...
  40. Gu W, Chen C, Wu Q, Lu J, Liu Y, Zhang S. Effects of Chinese herb medicine Radix Scrophulariae on ventricular remodeling. Pharmazie. 2010;65:770-5 pubmed
    ..ERS has beneficial effect against ventricular remodeling. The mechanism may be related to decreasing the level of Ang II and cardiac fibrosis, modulating some gene expressions associated with cardiac hypertrophy...
  41. Han J, Lowary T. Total synthesis of buergerinin F and buergerinin G. J Org Chem. 2003;68:4116-9 pubmed
    ..A linear sequence was used to synthesize 1 in 15 steps and 9% overall yield from thymidine. Subsequent oxidation of 1 with ruthenium tetroxide afforded 2 in 77% yield...
  42. Chen D, Li L, Peng R, Wu Y, Cai Y. [Analysis of genetic difference among Scrophularia ningpoensis cultivars by SRAP]. Zhongguo Zhong Yao Za Zhi. 2009;34:138-42 pubmed
    The genetic difference among Scrophularia ningpoensis cultivars were analyzed in molecular level.
  43. Li X, Fang D, Cong X, Cao G, Cai H, Cai B. Application of Fourier transform near-infrared spectroscopy combined with high-performance liquid chromatography in rapid and simultaneous determination of essential components in crude Radix Scrophulariae. AAPS PharmSciTech. 2012;13:1428-35 pubmed publisher
    ..028. The developed models were applied to unknown samples with satisfactory results. The established method was validated and can be applied to the intrinsic quality control of crude Radix Scrophulariae...
  44. Navarro Pérez M, Lopez J, Fernández Mazuecos M, Rodríguez Riaño T, Vargas P, Ortega Olivencia A. The role of birds and insects in pollination shifts of Scrophularia (Scrophulariaceae). Mol Phylogenet Evol. 2013;69:239-54 pubmed publisher
    The mixed vertebrate-insect pollination system is rare in Holarctic plants. Phylogenetic relationships of 116 Scrophularia taxa were investigated based on two plastid (ndhF and trnL-trnF) and one nuclear (ITS) DNA regions...
  45. Azadmehr A, Oghyanous K, Hajiaghaee R, Amirghofran Z, Azadbakht M. Antioxidant and neuroprotective effects of Scrophularia striata extract against oxidative stress-induced neurotoxicity. Cell Mol Neurobiol. 2013;33:1135-41 pubmed publisher
    In this study, the neuroprotective effect of Scrophularia striata Boiss (Scrophulariaceae) extract, a plant growing in northeastern of Iran, against oxidative stress-induced neurocytotoxicity in PC12 was evaluated...
  46. Li P, Zhang Y, Xiao L, Jin X, Yang K. Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study. Anal Bioanal Chem. 2007;389:2259-64 pubmed
    ..5 +/- 398.8 ng h mL(-1), and t(1/2) 4.9 +/- 1.3 and 2.5 +/- 0.9 h, respectively. These results indicated that the proposed method is simple, selective, and feasible for pharmacokinetic study of radix Scrophulariae extract in rats...
  47. Wu Q, Wen X, Qi L, Wang W, Yi L, Bi Z, et al. An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:751-6 pubmed publisher
    Harpagoside, a major bioactive iridoid glucoside in genus Scrophularia, has been widely used in clinical practice for the treatment of pain in the joints and lower back for its neuroprotective and anti-inflammation activities...
  48. Yang X, Yang S, Zhang X, Li L. [Determination of five compounds in Scrophularia ningpoensis by HPLC-UV-ELSD]. Zhongguo Zhong Yao Za Zhi. 2009;34:68-71 pubmed
    To develop an HPLC-UV-ELSD method for the determination of aucubi, harpagide, harpagoside, angoroside C and cinnamic acid in Scrophularia ningpoensis.
  49. Kim J, Kim Y, Lee H, Lim S, Park K. Effect of Scrophularia buergeriana extract on the degranulation of mast cells and ear swelling induced by dinitrofluorobenzene in mice. Inflammation. 2012;35:183-91 pubmed publisher
    b>Scrophularia buergeriana Miquel (Scrophulariaceae, SB) is a biennial plant native to Korea, northern China, and Japan that plays an important role in traditional medicine...
  50. Zhang X, Wang R, An R, Wu X, Wang X, Li Y. [Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC]. Zhongguo Zhong Yao Za Zhi. 2011;36:709-11 pubmed
    To develop an HPLC method for the simultaneous quantitation of five constituents in Scrophularia ningpoensis.
  51. Gu W, Chen C. [The study of Xuanshen on ventricular remodeling and cardiac endothelin-1 expression in rats treated with pressure-overload]. Zhong Yao Cai. 2008;31:393-6 pubmed
    ..To investigate the influence of Xuanshen on cardiac endothelin-1 expression, ventricular remodeling and its mechanism in rats treated with pressure-overload...
  52. Yan L, Song F, Han J, Su J, Qu F, Song Y, et al. [Fluorescence spectra analysis of the scrophularia soup]. Guang Pu Xue Yu Guang Pu Fen Xi. 2008;28:1891-4 pubmed
    The cold-water and boiled-water soaked scrophularia soups have been prepared. The emission and excitation spectra of each scrophularia soup under different conditions have been measured at room temperature...
  53. Manivannan A, Soundararajan P, Park Y, Jeong B. Chemical Elicitor-Induced Modulation of Antioxidant Metabolism and Enhancement of Secondary Metabolite Accumulation in Cell Suspension Cultures of Scrophularia kakudensis Franch. Int J Mol Sci. 2016;17:399 pubmed publisher
    b>Scrophularia kakudensis is an important medicinal plant with pharmaceutically valuable secondary metabolites...
  54. Azadmehr A, Afshari A, Baradaran B, Hajiaghaee R, Rezazadeh S, Monsef Esfahani H. Suppression of nitric oxide production in activated murine peritoneal macrophages in vitro and ex vivo by Scrophularia striata ethanolic extract. J Ethnopharmacol. 2009;124:166-9 pubmed publisher
    b>Scrophularia striata (Scrophulariaceae), a traditional Iranian medicine, has been used for the treatment of allergy, rheumatics and chronic inflammatory disorders.
  55. Chen D, Zhang X, Wang Y, Li L. [Genetic diversity of Scrophularia ningpoensis based on SCoT analysis]. Zhongguo Zhong Yao Za Zhi. 2012;37:2368-72 pubmed
    To explore the genetic diversity and relationship of different Scrophularia ningpoensis cultivars.
  56. Wang S, Ruan J, Zhao Y, Zhang Z. Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies. Biomed Chromatogr. 2008;22:50-7 pubmed
    ..The method was successfully applied to the pharmacokinetic study of harpagoside and cinnamic acid following oral administration of Radix Scrophulariae extract to rats...
  57. Chen C, Duan L, Zhou X, Chen B, Fu C. Molecular authentication of geo-authentic Scrophularia ningpoensis. J Zhejiang Univ Sci B. 2011;12:393-8 pubmed publisher
    b>Scrophularia ningpoensis has long been used in the Chinese Materia Medica for inflammation. Like other herbal medicines, S...
  58. Yang S, Li J, Zhao Y, Chen B, Fu C. Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl. J Agric Food Chem. 2011;59:1612-21 pubmed publisher
    b>Scrophularia ningpoensis Hemsl. is an important Chinese medicinal herb with a history of domestication of over 1000 years. Phytochemical variation of S...
  59. Wu B, Liu P, Gao Y, Wang Y. [Effect of water extract from traditional Chinese medicines Rehmannia glutinosa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas on contents of CYP450 and activities of CYP3A, CYP2E1 and CYP1A2 in rat]. Zhongguo Zhong Yao Za Zhi. 2011;36:2710-4 pubmed
    To study the effects of the water extract of Rehmannia glutionsa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas, which are the drug from Tianwang Buxin Wan from nourishing vin, on the content of cytohrome ..
  60. Jensen S, Calis I, Gotfredsen C, Søtofte I. Structural revision of some recently published iridoid glucosides. J Nat Prod. 2007;70:29-32 pubmed
    ..Another compound named harpagoside-B, isolated from Scrophularia deserti and proposed to be 9-epi-6-O-methylharpagoside (11), was demonstrated from the spectroscopic data given ..
  61. Chen B, Liu Y, Liu H, Wang N, Yang B, Yao X. Iridoid and aromatic glycosides from Scrophularia ningpoensis Hemsl. and their inhibition of [Ca2+](i) increase induced by KCl. Chem Biodivers. 2008;5:1723-35 pubmed publisher
    Bioassay-guided fractionation of EtOH extract of the roots of Scrophularia ningpoensis Hemsl. resulted in the isolation of three new iridoid glycosides, i.e...
  62. Xu C, Luo L, Tan R. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model. J Ethnopharmacol. 2004;91:345-9 pubmed
    Plantago asiatica, Scrophularia ningpoensis and Ilex pubescens are among the traditional Chinese medicines which are more frequently prescribed for treating depression-like ailments in the past and present traditional Chinese medical ..
  63. Sesterhenn K, Distl M, Wink M. Occurrence of iridoid glycosides in in vitro cultures and intact plants of Scrophularia nodosa L. Plant Cell Rep. 2007;26:365-71 pubmed
    Shoot, root, and callus cultures of Scrophularia nodosa L. (Scrophulariaceae) were established and cultivated in vitro...
  64. Bas E, Recio M, Abdallah M, Máñez S, Giner R, Cerda Nicolas M, et al. Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside. J Ethnopharmacol. 2007;110:419-27 pubmed
    We have studied scrovalentinoside, an iridoid with anti-inflammatory properties isolated from Scrophularia auriculata ssp. pseudoauriculata, as an anti-inflammatory agent in different experimental models of delayed-type hypersensitivity...
  65. Wang B, Wu W, Feng X, Li Z, Sun W. [Study on HPLC fingerprint of Herba Veronicae Dilatatae]. Zhong Yao Cai. 2004;27:95-7 pubmed
    ..To establish HPLC fingerprint of Herba Veronicae Dilatatae...
  66. Xu P, Zheng Y, Lv X, Yao S, Chen X. Biological characteristics of Cionus latefasciatus (Coleoptera: Curculionidae) and effects of temperature on its growth and development. J Econ Entomol. 2009;102:1039-43 pubmed
    Cionus latefasciatus Voss (Coleoptera: Curculionidae) is one of the most important insect pests on Scrophularia ningpoensis Hemsl...
  67. Monsef Esfahani H, Hajiaghaee R, Shahverdi A, Khorramizadeh M, Amini M. Flavonoids, cinnamic acid and phenyl propanoid from aerial parts of Scrophularia striata. Pharm Biol. 2010;48:333-6 pubmed publisher
    No phytochemical investigation regarding Scrophularia striata Boiss. (Scrophulariaceae) has been performed, although several reports about other Scrophularia species have been published. The inhibitory effects of aerial parts of S...
  68. Kim H, Park J, Lee K, Lee D, Kwak J, Kim Y, et al. Ferulic acid protects against carbon tetrachloride-induced liver injury in mice. Toxicology. 2011;282:104-11 pubmed publisher
    Ferulic acid (FA), isolated from the root of Scrophularia buergeriana, is a phenolic compound possessing antioxidant, anticancer, and antiinflammatory activities...
  69. Chen X, Liu Y, Chen P. Iridoid glycosyl esters from Scrophularia ningpoensis. Nat Prod Res. 2007;21:1187-90 pubmed
    ..glycosyl ester, scrophulninoside A (1), as well as the known compounds (2-3), were isolated from the n-BuOH soluble fraction of the Scrophularia ningpoensis. The structure of scrophulninoside A (1) was elucidated by spectroscopic methods.
  70. Azadmehr A, Hajiaghaee R, Mazandarani M. Induction of apoptosis and G2 /M cell cycle arrest by Scrophularia striata in a human leukaemia cell line. Cell Prolif. 2013;46:637-43 pubmed publisher
    b>Scrophularia striata Boiss (Scrophulariaceae) is a plant that grows in northeastern Iran; it has been used traditionally to treat various inflammatory disorders. This study was designed to investigate cytotoxic effects of S...
  71. Bhattacharyya S, Dey N, Maiti I. Analysis of cis-sequence of subgenomic transcript promoter from the Figwort mosaic virus and comparison of promoter activity with the cauliflower mosaic virus promoters in monocot and dicot cells. Virus Res. 2002;90:47-62 pubmed
    ..The FMV Sgt promoter is a constitutive promoter; expression level in seedlings was in the order: root>leaf>stem...
  72. Tasdemir D, Brun R, Franzblau S, Sezgin Y, Calis I. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine. 2008;15:209-15 pubmed
    ..1-3), the first resin glycosides occurring in another family (Scrophulariaceae), and the other constituents of Scrophularia cryptophila were examined for in vitro antiprotozoal and antimycobacterial potentials...
  73. Huang C, Shang Y, Zhang J, Zhang J, Li W, Jiao B. Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice. Am J Chin Med. 2008;36:149-57 pubmed
    Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl...
  74. Vranckx G, Vandelook F. A season- and gap-detection mechanism regulates seed germination of two temperate forest pioneers. Plant Biol (Stuttg). 2012;14:481-90 pubmed publisher
    ..Digitalis purpurea and Scrophularia nodosa are two small-seeded herbaceous species that typically grow in vegetation gaps in European temperate ..
  75. Zhang L, Guo F, Wang S, Li Y. A new triterpenoid tetrasaccharide from the root of Scrophularia ningpoensis. Yao Xue Xue Bao. 2012;47:1358-62 pubmed
    ..along with three known phenylethyl glycosides (2-4), was isolated from the root of traditional Chinese medicine Scrophularia ningpoensis. Among them, compounds 2 and 3 were obtained from Scrophularia genus for the first time...
  76. Wu Q, Yuan Q, Liu E, Qi L, Bi Z, Li P. Fragmentation study of iridoid glycosides and phenylpropanoid glycosides in Radix Scrophulariae by rapid resolution liquid chromatography with diode-array detection and electrospray ionization time-of-flight mass spectrometry. Biomed Chromatogr. 2010;24:808-19 pubmed publisher
    ..The major fragmentation pathways of PGs in Radix Scrophulariae obtained through the MS data was schemed systematically for the first time, which provides a reference for other PGs derivatives...
  77. Kim S, Park J, Myung N, Moon P, Choi I, An H, et al. Scrophularia buergeriana regulates cytokine production in vitro. Immunopharmacol Immunotoxicol. 2009;31:246-52 pubmed publisher
    The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses...
  78. Safarzadeh E, Delazar A, Kazemi T, Orangi M, Shanehbandi D, Esnaashari S, et al. The Cytotoxic and Apoptotic Effects of Scrophularia Atropatana Extracts on Human Breast Cancer Cells. Adv Pharm Bull. 2017;7:381-389 pubmed publisher
    ..The present study was designed to explore the cytotoxic effects and the cell death mechanism of Scrophularia atropatana extracts...
  79. Yang X, Wang M, Shu S, Zou Z, Xiang K. [Damage and control of Agrotis ypsilon on Scrophularia ningpoensis]. Zhongguo Zhong Yao Za Zhi. 2009;34:2441-3 pubmed
    To study the damage of Agrotis ypsilon on Scrophularia ningpoensis and the control method, so as to provide scientific basis for its integrated pests management (IPM).
  80. Tian J, Ye X, Shang Y, Deng Y, He K, Li X. Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography. J Sep Sci. 2012;35:2659-64 pubmed publisher
    In this study, the bioactive component harpagoside and angroside C in the root of Scrophularia ningpoensis Hemsley was simultaneously separated by high-speed counter-current chromatography (HSCCC)...
  81. Germinara G, Frontera A, de Cristofaro A, Rotundo G. Insecticidal activity of different extracts from Scrophularia canina L. against Culex pipiens molestus Forskal (Diptera, Culicidae). J Environ Sci Health B. 2011;46:473-9 pubmed publisher
    ..activity of different extracts (aqueous, methyl alcohol, hexane and petroleum ether) of the aerial part of Scrophularia canina against the second and fourth-instar larvae and adult females of Culex pipiens molestus was investigated...
  82. Park S, Chae Y, Facchini P. Genetic transformation of the figwort, Scrophularia buergeriana Miq., an Oriental medicinal plant. Plant Cell Rep. 2003;21:1194-8 pubmed
    b>Scrophularia buergeriana Miq. (figwort) contains a diverse group of bioactive natural products and is used to treat a variety of ailments, including fever, constipation, neuritis, and laryngitis...
  83. Brodmann J, Emer D, Ayasse M. Pollinator attraction of the wasp-flower Scrophularia umbrosa (Scrophulariaceae). Plant Biol (Stuttg). 2012;14:500-5 pubmed publisher
    Certain species of Scrophularia (Scrophulariaceae), such as S. nodosa and S. umbrosa, are mainly pollinated by social wasps and are consequently described as wasp-flowers...
  84. Xi X, Liu G. [Influence of drug compatibility on extractive retes of chlorogenic acid and isochlorogenic acid in simiaoyonglan tang decoction]. Zhongguo Zhong Yao Za Zhi. 1999;24:694-6, 704 pubmed
    ..To study the influence of drug compatibility on the extractive rates of chlorogenic acid and isochlorogenic acid in Simiaoyonglan Tang (SMYAT) decoction...
  85. Tong S, Yan J, Lou J. Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography. Phytochem Anal. 2006;17:406-8 pubmed
    The bioactive component harpagoside was successfully separated from the crude extract of Scrophularia ningpoensis Hemsley by one-step purification using high-speed counter-current chromatography (HSCCC)...
  86. Fang H, Ning D, Liang X. [Studies on technology optimization for extracting triterpenoid saponins from Picria felterrae by multi-target grading method]. Zhong Yao Cai. 2009;32:1902-5 pubmed
    ..To study the optimum extraction conditions of triterpenoid saponins from Picria felterrae...