rehmannia

Summary

Summary: A plant genus of the family Rehmanniaceae. Members contain catapol, rehmannin and ALKALOIDS.

Top Publications

  1. Zhang X, An L, Bao Y, Wang J, Jiang B. d-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol. Food Chem Toxicol. 2008;46:2888-94 pubmed publisher
    The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh rehmannia roots, on the behavior and brain energy metabolism in senescent mice induced by d-galactose were assessed...
  2. Qi J, Li X, Song J, Eneji A, Ma X. Genetic relationships among Rehmannia glutinosa cultivars and varieties. Planta Med. 2008;74:1846-52 pubmed publisher
    Many cultivars of Rehmannia glutinosa are grown in China for medicinal uses, but detailed agronomic and morphological descriptions are available for only a few...
  3. Shieh J, Cheng K, Chung H, Kerh Y, Yeh C, Cheng J. Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats. J Agric Food Chem. 2011;59:3747-53 pubmed publisher
    Catalpol is one of the active principles from roots of Rehmannia glutinosa Steud (Scrophulariaceae) that is widely used to treat diabetic disorders in Chinese traditional medicine using the name of Di-Huang, which is used to investigate ..
  4. Lim D, Kim Y. Dried root of Rehmannia glutinosa prevents bone loss in ovariectomized rats. Molecules. 2013;18:5804-13 pubmed publisher
    Dried root of Rehmannia glutinosa is a kidney-tonifying herbal medicine with a long history of safe use in traditional folk medicine for the treatment of joint diseases...
  5. Chae H, Kim H, Kim D, Woo E, Cho Y, Chae S. Saeng-Ji-Hwang has a protective effect on adriamycin-induced cytotoxicity in cardiac muscle cells. Life Sci. 2005;76:2027-42 pubmed
    ..Overall, the results suggest that SJH-associated Mn-SOD and GSH are important factors in the mechanism of the SJH-induced protective mechanism in H9C2 cardiac muscle cells...
  6. Chang W, Thissen U, Ehlert K, Koek M, Jellema R, Hankemeier T, et al. Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy. Planta Med. 2006;72:458-67 pubmed
    ..quality control strategy in Traditional Chinese Medicine (TCM), we have measured the metabolite fingerprints of Rehmannia glutinosa by GC-MS...
  7. Yu H, Oh hashi K, Tanaka T, Sai A, Inoue M, Hirata Y, et al. Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1/2 pathways independently. Pharmacol Res. 2006;54:39-45 pubmed
    Among four herbs of traditional Chinese medicines (TCMs) used in the therapy of dementia, Rehmannia glutinosa (RG) was found to induce the gene expression of glial cell line-derived neurotrophic factor (GDNF) in C6 glioblastoma cells and ..
  8. Zhang R, Li M, Jia Z. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol. 2008;117:199-214 pubmed publisher
    b>Rehmannia glutinosa, a widely used traditional Chinese herb, belongs to the family of Scrophulariaceae, and is taken to nourish Yin and invigorate the kidney in traditional Chinese medicine (TCM) and has a very high medicinal value...
  9. Shin S, Park C, Yang C, Park J. Protective effect of Rehmannia glutinosa on the UV-induced apoptosis in U937 cells. Am J Chin Med. 2008;36:1159-70 pubmed
    ..The steamed root of Rehmannia glutinosa (Saeng Jihuang, SJH) is reported to have an antioxidant activity...

More Information

Publications133 found, 100 shown here

  1. Sung Y, Yoon T, Jang J, Park S, Kim H. Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice. J Ethnopharmacol. 2011;134:37-44 pubmed publisher
    b>Rehmannia glutinosa is known in Asia as a traditional herbal medicine with anti-inflammatory properties...
  2. Wu P, Wu S, Tsai Y, Lin Y, Chao J. Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats. Am J Chin Med. 2011;39:1173-91 pubmed
    Polysaccharide-rich Lycium barbarum and Rehmannia glutinosa have been considered to have immune-modulating activity...
  3. Cheng J, Huang L, Shao A, Lin S. [RAPD analysis on different varieties of Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2002;27:505-8 pubmed
    To provide molecular evidences for its breeding by studying the genetic relationship among varieties of Rehmannia glutinosa.
  4. Zhang X, Zhang A, Jiang B, Bao Y, Wang J, An L. Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa. Phytomedicine. 2008;15:484-90 pubmed publisher
    ..Catalpol may be a potential anti-aging agent and worth testing for further preclinical study aimed for senescence or neurodegenerative diseases such as Alzheimer's and Parkinson's diseases...
  5. Huang W, Niu H, Lin M, Cheng J, Hsu F. Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. J Nat Prod. 2010;73:1170-2 pubmed publisher
    The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus...
  6. Yook T, Yu J, Lee H, Song B, Kim L, Roh J, et al. Comparing the effects of distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix pharmacopuncture with heart rate variability (HRV): a randomized, sham-controlled and double-blind clinical trial. J Acupunct Meridian Stud. 2009;2:239-47 pubmed publisher
    This study compared the effects of distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix pharmacopuncture on the autonomic nervous system and heart rate variability...
  7. Lee B, Shim I, Lee H, Hahm D. Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats. J Microbiol Biotechnol. 2011;21:874-83 pubmed
    Many studies have shown that the steamed root of Rehmannia glutinosa (SRG), which is widely used in the treatment of various neurodegenerative diseases in the context of Korean traditional medicine, is effective for improving cognitive ..
  8. Li Z, Yang Y, Xie D, Zhu L, Zhang Z, Lin W. Identification of autotoxic compounds in fibrous roots of Rehmannia (Rehmannia glutinosa Libosch.). PLoS ONE. 2012;7:e28806 pubmed publisher
    b>Rehmannia is a medicinal plant in China. Autotoxicity has been reported to be one of the major problems hindering the consecutive monoculture of Rehmannia. However, potential autotoxins produced by the fibrous roots are less known...
  9. Huang Y, Jiang C, Hu Y, Zhao X, Shi C, Yu Y, et al. Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell. Carbohydr Polym. 2013;96:516-21 pubmed publisher
    The aim of this study is to investigate immunomodulatory effect of rehmannia glutinosa polysaccharide (RGP) on murine splenic lymphocyte and bone marrow derived dendritic cells (DCs)...
  10. Chao J, Chiang S, Wang C, Tsai Y, Wu M. Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells. World J Gastroenterol. 2006;12:4478-84 pubmed
    To investigate the effect of hot water-extracted Lycium barbarum (LBE) and Rehmannia glutinosa (RGE) on cell proliferation and apoptosis in rat and/or human hepatocellular carcinoma (HCC) cells.
  11. Chen H, Hao H, Xiong J, Qi X, Zhang C, Lin W. [Effects of successive cropping Rehmannia glutinosa on rhizosphere soil microbial flora and enzyme activities]. Ying Yong Sheng Tai Xue Bao. 2007;18:2755-9 pubmed
    With the soils cropped Rehmannia glutinosa for one and two years as test materials, this paper studied the variations of microbial flora and enzyme activities in rhizosphere...
  12. Sun P, Guo Y, Qi J, Zhou L, Li X. Isolation and expression analysis of tuberous root development related genes in Rehmannia glutinosa. Mol Biol Rep. 2010;37:1069-79 pubmed publisher
    ..In this study, we focused on the molecular profiling of the tuberous root development of Rehmannia glutinosa...
  13. Li J, Wang M, Lin Z, Yuan Q, Yu R, Huang L. [Isolation and identification of endophytic fungi from different swollen root of Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2010;35:1679-83 pubmed
    The swollen root of Rehmannia glutinosa is used as one kind of important Chinese traditional medicine. The root of R. glutinosa usually swelled in rotational cropping but not in continuous cropping. The rhizosphere microorganisms of R...
  14. Yang Y, Chen X, Chen J, Xu H, Li J, Zhang Z. Differential miRNA expression in Rehmannia glutinosa plants subjected to continuous cropping. BMC Plant Biol. 2011;11:53 pubmed publisher
    The productivity of the medicinally significant perennial herb Rehmannia glutinosa is severely affected after the first year of cropping...
  15. Wu L, Wang H, Zhang Z, Lin R, Zhang Z, Lin W. Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil. PLoS ONE. 2011;6:e20611 pubmed publisher
    The consecutive monoculture for most of medicinal plants, such as Rehmannia glutinosa, results in a significant reduction in the yield and quality...
  16. Zhang R, Zhou J, Jia Z, Zhang Y, Gu G. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol. 2004;90:39-43 pubmed
    The hypoglycemic and anti-diabetic effect of Rehmannia glutinosa oligosaccharide (ROS) in glucose-induced hyperglycemic and alloxan-induced diabetic rats and its mechanism was investigated in this paper...
  17. Kim S, Son Y, Chun J, Kim S, Chung G, Hwang K, et al. Antioxidant property of an active component purified from the leaves of paraquat-tolerant Rehmannia glutinosa. Redox Rep. 2005;10:311-8 pubmed
    Acteoside extracted from the leaves of Rehmannia glutinosa was examined to determine the mechanism(s) of its antioxidant properties...
  18. Chang W, Choi Y, van der Heijden R, Lee M, Lin M, Kong H, et al. Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots. Chem Pharm Bull (Tokyo). 2011;59:546-52 pubmed
    ..The root of Rehmannia glutinosa has to be processed by nine cycles of rice wine immersing, steaming and drying before using in ..
  19. Poon T, Ong K, Cheung B. Review of the effects of the traditional Chinese medicine Rehmannia Six Formula on diabetes mellitus and its complications. J Diabetes. 2011;3:184-200 pubmed publisher
    b>Rehmannia Six Formula (RF) is a formula that is commonly used in Traditional Chinese Medicine to treat patients with diabetes...
  20. Liu C, Cheng L, Ko C, Wong C, Cheng W, Cheung D, et al. Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway. J Ethnopharmacol. 2012;143:867-75 pubmed publisher
    The root of Rehmannia glutinosa (RR) is commonly used to reduce inflammation in various traditional Chinese herbal formulae; however, little is known regarding its active component(s).
  21. Cui Y, Yan Z, Hou S, Chang Z. [Intelligence enhancement of radix Rehmanniae praeparata and some comments on its research]. Zhongguo Zhong Yao Za Zhi. 2002;27:404-6, 456 pubmed
  22. Zhang X, Zhang Y, Zhao J, Liu C, Wang S, Yang L, et al. Nonomuraea fuscirosea sp. nov., an actinomycete isolated from the rhizosphere soil of rehmannia (Rehmannia glutinosa Libosch). Int J Syst Evol Microbiol. 2014;64:1102-7 pubmed publisher
    A novel actinomycete, designated strain NEAU-dht8(T), was isolated from the rhizosphere soil of rehmannia (Rehmannia glutinosa Libosch) and characterized using a polyphasic approach...
  23. Han Y, Jung H, Lee J, Kim J, Kang S, Kim Y, et al. 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food. 2012;15:505-10 pubmed publisher
    Rehmanniae Radix Preparata, the steamed root of Rehmannia glutinosa Libosch, has been widely used for the treatment of inflammatory conditions in Oriental medicines...
  24. Ok H, Gebreamanuel M, Oh S, Jeon H, Lee W, Kwon O. A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet. Calcif Tissue Int. 2015;97:624-33 pubmed publisher
    The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis)...
  25. Lee S, Kim J, Choi R, Kim Y, Lee J, Kang S. A new polyoxygenated triterpene and two new aeginetic acid quinovosides from the roots of Rehmannia glutinosa. Chem Pharm Bull (Tokyo). 2011;59:742-6 pubmed
    ..named glutinolic acid (1) and two new aeginetic acid quinovosides (2, 3) were isolated from the roots of Rehmannia glutinosa LIBOSCH. (Scrophulariaceae) cultivated in Gunwi-gun, Korea...
  26. Shao J, Liu Z, Wang L, Song Z, Chang H, Han N, et al. Screening of the optimized prescription from Suqingwan in terms of its therapeutic effect on DSS-induced ulcerative colitis by its regulation of inflammatory and oxidative mediators. J Ethnopharmacol. 2017;202:54-62 pubmed publisher
    ..b>Rehmannia glutinosa Libosch. and four other herbal medicines...
  27. Liu Y, Liu L, Ying X, Wei W, Han C, Liu Y, et al. Dried Rehmannia root protects against glutamate-induced cytotoxity to PC12 cells through energy metabolism-related pathways. Neural Regen Res. 2017;12:1338-1346 pubmed publisher
    b>Rehmannia has been shown to be clinically effective in treating neurodegenerative diseases; however, the neuroprotective mechanisms remain unclear...
  28. Cao X, Yang Y, Feng F, Li M, Gu L, Wang F, et al. [Research progress of relationship between continuous cropping obstacles and microRNAs in Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2017;42:1104-1108 pubmed publisher
    The efficacy of Rehmannia glutinosa which as a large quantity of traditional Chinese medicine is significant. However, the land must be given up after one season of R...
  29. Wen X, Lou H, Yang S, Li X, Cheng X, Xu L, et al. [Photosynthetic pigment contents of different germplasm of Rehmannia glutinosa and the relationship between pigments and leaf color]. Zhongguo Zhong Yao Za Zhi. 2002;27:828-31 pubmed
    To evaluate the germplasm of Rehmannia glutinosa on the basis of photosynthetic pigment contents (PPC). 20 cultivars were planted on the same condition. On Oct. 23 and Sept...
  30. Meng Q, Lv X, Jin X. [Effect of Rehmannia glutinosa Libosch water extraction on gene expression of proinsulin in type 2 diabetes mellitus rats]. Zhong Yao Cai. 2008;31:397-9 pubmed
    To investigate the mechanisms of treating 2-DM by Rehmannia glutinosa Libosch water extraction (RGLE). The mRNA level of proinsulin in rats panreas tissue was examined by semi-quatitativa RT-PCR,and the protein was measured by SDS-PAGE...
  31. Wang H, Liu T, Zhu Y, Guan S, Ma X, Cui Z. Effect of protocatechuic acid from Alpinia oxyphylla on proliferation of human adipose tissue-derived stromal cells in vitro. Mol Cell Biochem. 2009;330:47-53 pubmed publisher
    The effect of protocatechuic acid (PCA) from Alpinia oxyphylla and catapol from Rehmannia on the proliferation capacity of human adipose tissue-derived stromal cells (hADSCs) was investigated in vitro...
  32. Licciardi P, Underwood J. Identification of a novel vaccine adjuvant that stimulates and maintains diphtheria toxoid immunity. Vaccine. 2010;28:3865-73 pubmed publisher
    ..This study reports potent and long-lasting diphtheria toxoid-specific immunity by the botanical medicinal, Rehmannia Six Formula, using an in vivo mouse model of vaccine immunity...
  33. Park H, Kim J, Lee Y, Chun H, Choi Y, Shin H, et al. PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice. Neurosci Lett. 2016;617:254-63 pubmed publisher
    ..PMC-12), which is a mixture of four medicinal herbs, that is, Polygonum multiflorum, Polygala tenuifolia, Rehmannia glutinosa, and Acorus gramineus, on hippocampal neurogenesis, learning, and memory in mice...
  34. Liu Y, Shi G, Wang X, Zhang C, Wang Y, Chen R, et al. Nine new compounds from the whole plants of Rehmannia chingii. J Asian Nat Prod Res. 2016;18:509-19 pubmed publisher
    Nine new compounds, together with 16 known analogs, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1-9 were elucidated on the basis of their spectroscopic data and chemical evidence...
  35. Park E, Kang M, Oh J, Jung M, Park C, Cho C, et al. Yukmijihwang-tang derivatives enhance cognitive processing in normal young adults: a double-blinded, placebo-controlled trial. Am J Chin Med. 2005;33:107-15 pubmed
    ..YMJd treatment may help dementia patients or the elderly recover from cognition deficiencies or degeneration in clinic. ..
  36. Wang J, Kong H, Yuan Z, Gao P, Dai W, Hu C, et al. A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect. J Pharm Biomed Anal. 2013;83:57-64 pubmed publisher
  37. Lien A, Jiang Y, Mou C, Sun M, Gau B, Yen H. Integrative traditional Chinese medicine therapy reduces the risk of diabetic ketoacidosis in patients with type 1 diabetes mellitus. J Ethnopharmacol. 2016;191:324-330 pubmed publisher
    ..The most common Chinese herbal formula and single herb is Liu-wei-di-huang-wan (Six-ingredient pill of Rehmannia) and Huang-qi (Radix Astragali; Astragalus membranaceus (Fisch.) Bunge, Astragalus membranaceus var...
  38. Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X. Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. Int J Biol Sci. 2017;13:327-338 pubmed publisher
    Catalpol and puerarin are two monomers of Rehmannia glutinosa and Lobed Kudzuvine Root, which are two herbs commonly used together in ancient prescriptions of traditional Chinese medicine for cerebral ischemia...
  39. Guo X, Zhang R, Jia Z, Li M, Wang J. [Effects of Rehmannia glutinosa oligosaccharides on proliferation of 3T3-L1 adipocytes and insulin resistance]. Zhongguo Zhong Yao Za Zhi. 2006;31:403-7 pubmed
    To investigate the influence of Rehmannia glutinosa oligosaccharides (ROS) on the proliferation of 3T3-L1 adipocytes and insulin resistance...
  40. Lang Q, Ma B, Li W, Zhang C, Wang H, Zhang S, et al. [Investigation of constituents in siwu tang fractions by chromatographic and ESI-MS methods]. Zhongguo Zhong Yao Za Zhi. 2004;29:334-9 pubmed
    ..The results of this study are important as references for the discussion of the chemical foundation of hematopoietic effect of Siwu Tang. ..
  41. Chen S, Yuan Y, Luo Y, Huang L, Chen P, Li X. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. Zhongguo Zhong Yao Za Zhi. 2010;35:682-5 pubmed
    ..995). Active ingredients and related genes (PAL, UBGAT) in suspension cultures of S. baicalensis were promoted significantly by light. ..
  42. Cao J, Liang Z, Yang D, Liu Y, Duan Q. [End point determination by HPLC chromatographic fingerprint in processing prepared Rehmannia]. Zhongguo Zhong Yao Za Zhi. 2010;35:2556-60 pubmed
    ..content variations of three important active components catalpol, 5-hydroxymethylfurfural and acteoside in Rehmannia rhizome were analyzed during processing, as well as changes of the fingerprints...
  43. Kim T, Kim S, Sung S. Quantitation of ?-galactosides in Rehmannia glutinosa by hydrophilic interaction chromatography-evaporative light scattering detector. Phytochem Anal. 2012;23:607-12 pubmed publisher
    ..b>Rehmannia glutinosa is reported to contain RFOs; however, there are no reports on their content level in R. glutinosa...
  44. Zhang Q, Fong C, Yu W, Chen Y, Wei F, Koon C, et al. Herbal formula Astragali Radix and Rehmanniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27 via the activation of transformation growth factor (TGF-?) pathway and promoting extracellular matrix (ECM) deposition. Phytomedicine. 2012;20:9-16 pubmed publisher
    ..NF3 could regulate gene transcription for extracellular matrix synthesis via the Smad pathway, and gene transcription for cell motility via the Ras/MAPK (non-Smad) pathway. ..
  45. Fan H, Li M, Zheng H, Yang Y, Gu L, Wang F, et al. [Spatiotemporal expression and analysis of responding consecutive monoculture genes in Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2012;37:3029-35 pubmed
    ..SSH) technique to construct the forward and reverse subtractive cDNA libraries of consecutive monoulture Rehmannia glutinosa. Five genes related with consecutive monoculture problem of R...
  46. Huang L, Sun S, Zheng Y. [Simultaneous determination and optimization of extraction process of catalpol and acteoside from rehmanniae radix]. Zhong Yao Cai. 2012;35:1318-22 pubmed
    ..The accuracy and precision of the developed HPLC protocol is adequate for simultaneous quantification of Catalpol and Acteoside in Rehmanniae Radix. The optimized extraction condition could be obtained by RSM using CCD. ..
  47. Xue J, Xue T, Guo L, Zhu Y, Lu H, Zhang A, et al. [Study on optimization of induction system of test-tube tuberous roots from leaves of Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2012;37:3812-4 pubmed
    ..sucrose and plant growth substances of different concentrations on the induction of test-tube tuberous roots of Rehmannia glutinosa, in order to establish an efficient system for the induction of test-tube tuberous roots from leaves ..
  48. Anh N, Sung T, Franke K, Wessjohann L. Phytochemical studies of Rehmannia glutinosa rhizomes. Pharmazie. 2003;58:593-5 pubmed
    ..and the calcium salt of rehmapicroside (2) have been isolated from rhizomes of the Vietnamese variety of Rehmannia glutinosa Libosch together with a series of known compounds: norcarotenoids (3-5), 2-formyl-5-hydroxy-..
  49. Bai Y, Fan K, Li J, Wang D, Chen Z. [The correlation between 2D-IR and HPLC in dried Rehmannia glutinosa processed by different processing techniques]. Zhongguo Zhong Yao Za Zhi. 2005;30:504-7 pubmed
    ..There are good correlations between their datas. It is properly to evaluate the quality of dried R. glutinosa processed by different processing techniques and different producing areas. ..
  50. Wu L, Wang H, You C, Zhang Z, Niu M, Zhang Z, et al. [Establishment of extraction method and 2-dimensional electrophoresis conditions for root tuber proteome analysis of Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2011;36:984-7 pubmed
    ..and high resolution 2-DE (two-dimensional electrophoresis) protocol for root tuber proteome analysis of Rehmannia glutinosa. Proteins from root tuber of R...
  51. Song M, Chen Y, Du H, Zhang S, Wang Y, Zeng L, et al. RAW REHMANNIA RADIX POLYSACCHARIDE CAN EFFECTIVELY RELEASE PEROXIDATIVE INJURY INDUCED BY DUCK HEPATITIS A VIRUS. Afr J Tradit Complement Altern Med. 2017;14:8-21 pubmed publisher
    ..Duck viral hepatitis (DVH), caused by duck hepatitis A virus (DHAV), is a fatal contagious infectious disease which spreads rapidly with high morbidity and high mortality, and there is no effective clinical drug against DVH...
  52. Liu H, Lin F, Li E, Wu M, Tong X. [The influence of the different components of nourishing kidney herbs on osteoporosis rats]. Zhongguo Zhong Yao Za Zhi. 2003;28:262-5 pubmed
  53. Guo C, Bai X, Zhang W, Wang Z, Fu Y. [Determination of catalpol in dried rehmannia root and Taohong Siwu Decoction with high performance liquid chromatography]. Zhong Xi Yi Jie He Xue Bao. 2004;2:135-7 pubmed
    To determinate the catalpol contents in dried rehmannia root and Taohong Siwu Decoction containing rehmannia root with high performance liquid chromatography (HPLC). Catalpol was separated on a YWG-C18 column using water-acetonitrile (99...
  54. Lau T, Chan Y, Lau C, Lau K, Lau C, Fung K, et al. Radix Astragali and Radix Rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues. Phytother Res. 2009;23:809-15 pubmed publisher
    ..The results in this study indicate that fibroblast viability enhancement effects of RA and RR likely underlie the healing effects of F1 and F2 in diabetic foot ulcers. ..
  55. Liu C, Tam J, Sanders A, Ko C, Fung K, Leung P, et al. Molecular angiogenic events of a two-herb wound healing formula involving MAPK and Akt signaling pathways in human vascular endothelial cells. Wound Repair Regen. 2013;21:579-87 pubmed publisher
    ..Hence, we demonstrated the complexity of the angiogenic effect activated by NF3 molecularly and functionally. NF3 treatment could offer therapeutic value to chronic wound healing for its pro-angiogenic efficacy. ..
  56. Wei G, Liu H, Wen X, Guo Y. [Discussion on the quality marker of rehmanniae radix praeparata in the Chinese Pharmacopoeia]. Zhong Yao Cai. 2013;36:853-6 pubmed
    ..It is unreasonable that RR and RRP have the same standard in the content of verbascoside. It is suggested that the maximum limit of verboscoside should be set in the new version of Chinese pharmacopoeia. ..
  57. Wen X, Wei J, Yang S, Ma X. [Preservation of germplasm of Rehmannia glutinosa in vitro]. Zhongguo Zhong Yao Za Zhi. 2003;28:17-20 pubmed
    ..10 months later, most of the preserved plantlets browned and wilted except those on medium A. The low temperature endurance of R. glutinosa is cultivar-dependent. Medium A can preserve "85-5" for more than 10 months in vitro. ..
  58. Tan W, Song C, Tan H, Liu L, Ma Z, Wang Y, et al. [Hematopoietic effect of siwu decoction in the mice with blood deficiency induced by compound method of bleeding, starved feeding and exhausting]. Zhongguo Zhong Yao Za Zhi. 2005;30:926-9 pubmed
    ..58% which were significantly higher than that in model group without treatment of Siwu Decoction. Siwu decoction significantly improve the hematopoiesis in the mice with blood deficiency induced by compound method mentioned above. ..
  59. Wang X, Yang M, Liu F, Lu F, Xu L, Zou X. [Effect of Rhizoma coptidis and Radix rehmanniae with different ratio on pharmacokinetics of berberine in rats]. Zhongguo Zhong Yao Za Zhi. 2007;32:1795-7 pubmed
    ..Difference of 4groups in C(max), AUC(0-t), AUC(0-infinity), is significant (P <0.05). Radix Rehmanniae of large dose can effectively enhance berberine's bioavailability in rats. ..
  60. Zhang R, Zhao Y, Sun Y, Lu X, Yang X. Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa Libosch. J Agric Food Chem. 2013;61:7786-93 pubmed publisher
    ..was aimed to isolate and characterize the raffinose family oligosaccharides (RGOs) from a novel plant source of Rehmannia glutinosa Libosch, and further evaluate whether RGOs can attenuate CCl4-induced oxidative stress and hepatopathy ..
  61. Sun Y, Wen X, Zhao Y, Shen T, Liu Z, Gao H, et al. Yeast exposure in the preparation of steamed rehmannia root improving its effects on alloxan-induced diabetic rats. J Ethnopharmacol. 2013;150:514-20 pubmed publisher
    The root of Rehmannia glutinosa (Gaertn.) DC. has been used in China for more than 2000 years to treat various diseases including diabetes mellitus (DM) and its complications. Steamed rehmannia root (SRR) is one of the mainly used forms...
  62. Liang Q, Lu X, Ma Z, Tan H, Ma B, Gao Y, et al. [Preliminary study on hematopoietic constituents of si-wu-tang]. Zhongguo Zhong Yao Za Zhi. 2004;29:546-9 pubmed
    ..Fraction C2, C3, B and paeoniflorin could promote the proliferation of hematopoietic progenitor cell in bone marrow of radiated mice. Fraction C2, C3, B and paeoniflorin are responsible for hematopoietic activity of si-wu-tang. ..
  63. Li M, Yang Y, Feng F, Zhang B, Chen S, Yang C, et al. Differential proteomic analysis of replanted Rehmannia glutinosa roots by iTRAQ reveals molecular mechanisms for formation of replant disease. BMC Plant Biol. 2017;17:116 pubmed publisher
    The normal growth of Rehmannia glutinosa, a widely used medicinal plant in China, is severely disturbed by replant disease...
  64. Zhu M, Liu X, Ju hee O, Chang soo Y, Je Hyun L. [Effect of concentration of catalpol and 5-hydroxymethyl-2-furaldehyde from processing of Rehmanniae Radix]. Zhongguo Zhong Yao Za Zhi. 2007;32:1155-7 pubmed
    ..Analyze the effect of concentration of catalpol and 5-HMF from Rehmanniae Radix at various processing, and provide the foundation for further study. ..
  65. Liu Y, Liang D, Luo H, Hao Z, Wang Y, Zhang C, et al. Ionone glycosides from the roots of Rehmannia glutinosa. J Asian Nat Prod Res. 2014;16:11-9 pubmed publisher
    ..and a new monoterpene (5), together with 10 known analogues (6-15), were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis...
  66. Xu L, Zhang W, Zeng L, Jin J. Rehmannia glutinosa polysaccharide induced an anti-cancer effect by activating natural killer cells. Int J Biol Macromol. 2017;105:680-685 pubmed publisher
    b>Rehmannia glutinosa polysaccharide (RGP) has exhibited an immune stimulatory effect, such as dendritic cell activation, but it has not been studied in terms of the activation capacity of natural killer (NK) cells in mice in vivo...
  67. Xue J, Shi L, Zhang A. [Microtuber induction in vitro from Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2002;27:824-7 pubmed
    ..active carbon and light time influenced formation of adventitious root and microtuber in vitro from plantlet of Rehmannia glutinosa (85-5)...
  68. Zhang D, Wen X, Wang X, Shi M, Zhao Y. Antidepressant effect of Shudihuang on mice exposed to unpredictable chronic mild stress. J Ethnopharmacol. 2009;123:55-60 pubmed publisher
    Depression is a severe mood disorder. It was treated with Shudihuang, the steamed roots of Rehmannia glutinota Libosch. (SRG), in traditional Chinese medicine. The present paper was designed to verify its antidepressant effect...
  69. Lau T, Lam F, Lau K, Chan Y, Lee K, Sahota D, et al. Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J Ethnopharmacol. 2009;123:155-62 pubmed publisher
    ..The present study provided scientific basis to support the traditional use of Radix Rehmanniae in diabetic foot ulcer. ..
  70. Li S, Song J, Qiao C, Zhou Y, Qian K, Lee K, et al. A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis. J Pharm Biomed Anal. 2010;51:812-23 pubmed publisher
    ..This newly proposed strategy can not only be used to explore chemical markers but also to investigate the chemical transforming mechanisms underlying traditional herb processing. ..
  71. Lee B, Lee H, Jung Y, Kim S, Lee Y, Chang S, et al. The effects of a novel botanical agent on lipopolysaccharide-induced alveolar bone loss in rats. J Periodontol. 2013;84:1221-9 pubmed publisher
    ..A botanical mixture of extracts from two natural substances, Panax notoginseng and Rehmannia glutinosa Libosch, was developed as a novel botanical agent synthesized with anti-inflammatory effect...
  72. Qiu H, Fan W, Fu P, Zuo C, Feng P, Liu F, et al. General acteoside of Rehmanniae leaves in the treatment of primary chronic glomerulonephritis: a randomized controlled trial. Afr J Tradit Complement Altern Med. 2013;10:109-15 pubmed
    ..5%) and control group (2.5%, P = 0.7238). Both general acteoside of Rehmanniae leaves and piperazine ferulate can reduce proteinuria and erythrocyturia effectively in the treatment of primary chronic glomerulonephritis. ..
  73. Zhao P, Li H, Lei Y, Li T, Kim S, Kim I. Effect of fermented medicinal plants on growth performance, nutrient digestibility, fecal noxious gas emissions, and diarrhea score in weanling pigs. J Sci Food Agric. 2016;96:1269-74 pubmed publisher
    ..No studies have evaluated the use of fermented medicinal plants (FMP) made up of Gynura procumbens, Rehmannia glutinosa and Scutellaria baicalensis in weanling pigs...
  74. Guo P, Wang S. [Effects of Siwu Tang on protein expression of HFCL]. Zhongguo Zhong Yao Za Zhi. 2006;31:1083-6 pubmed
    ..Through promoting HFCL proliferation and acting on multipleprotein targets, the blood enriching function of Siwu Tang was exerted indirectly. ..
  75. Zhou L, Yi W, Qi J, Sun P, Niu S, Jiao L, et al. [Effects of seedling quality on growth of Rehmannia glutinosa and oligosaccharide content]. Zhongguo Zhong Yao Za Zhi. 2012;37:2037-40 pubmed
    To study the effect of seedling quality on growth, yield and quality of Rehmannia glutinosa at harvest and build a basis for its GAP. The seedling quality of R...
  76. Peng W, You F, Li X, Jia M, Zheng C, Han T, et al. A new diphenyl ether from the endophytic fungus Verticillium sp. isolated from Rehmannia glutinosa. Chin J Nat Med. 2013;11:673-5 pubmed publisher
    To investigate the chemical constituents of the endophytic fungus Verticillium sp. isolated from Rehmannia glutinosa...
  77. Li X, Yang S, Yang J. [Comparison and correlative analysis on characters of Rehmannia glutinosa Libosch. Varieties]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23:560-2 pubmed
    To compare the economical characters, yield characters and content of catalpol on Rehmannia glutinosa Libosch. varieties. To study characters by field randomized block test and analysis of variance...
  78. Wang G, Hou Z, Tang Y, Zhao J, Sun Y, Dong C, et al. Determination of endpoint of procedure for radix rehmanniae steamed based on ultraviolet spectrophotometry combination with continuous wavelet transform and kernel independent component analysis. Anal Chim Acta. 2010;679:43-8 pubmed publisher
    ..It provides an alternative approach for determination of the endpoint of the procedure for processing traditional Chinese medicine (TCM). ..
  79. Baek G, Jang Y, Jeong S, Cha J, Joo M, Shin S, et al. Rehmannia glutinosa suppresses inflammatory responses elicited by advanced glycation end products. Inflammation. 2012;35:1232-41 pubmed publisher
    Fresh rhizome of Rehmannia glutinosa Libosch. (Saeng-jihwang in Korean: SJH) has been prescribed for the treatment of diabetes-associated complications...
  80. Kim M, Lee C, Yook T. Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. J Acupunct Meridian Stud. 2013;6:98-109 pubmed publisher
  81. Kubota K, Fukue H, Sato H, Hashimoto K, Fujikane A, Moriyama H, et al. The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB. Front Pharmacol. 2017;8:850 pubmed publisher
    ..05; 10-500 ?g/ml HJG, p < 0.001). While six herbal constituents of HJG, Rehmannia root, Dioscorea rhizome, Rhizoma Alismatis, Poria sclerotium, Moutan bark, and Cinnamon bark, could induce ..
  82. Xue J, Ge D, Zhang A, Liu J. [Progress on research of tissue culture of Rehmannia glutinosa]. Zhongguo Zhong Yao Za Zhi. 2003;28:1114-7 pubmed
    To review the development of tissue culture on Rehmannia glutinosa. Documentaries at home and abroad were consulted. The tissue culture conditions of R. glutinosa were summarized and the problems of tissue culture in R...
  83. Zhou Y, Jing J, Li Z, Zhang B, Jia J. [Assessment of genetic diversity of Rehmannia glutinosa germplasm detected by RAPDs and ISSRs]. Yi Chuan. 2004;26:922-8 pubmed
    RAPD and ISSR markers were used to assess the germplasm genetic diversity among 10 individuals of Rehmannia glutinosa, including 8 cultivars and 2 virus-free lines micropropagated by tip tissue culture...
  84. Mao X, Zhong Y, Yan A, Wang B, Wang Y, Wan Y. Simultaneous determination of organochlorine and pyrethriod pesticide residues in the Chinese patent medicines by gas chromatography-tandem mass spectrometry. J Environ Sci Health B. 2017;:1-9 pubmed publisher
    ..determination of organochlorine and pyrethriod pesticide residues in Chinese patent medicines Six ingredient rehmannia pills and Xiaoyao pills. These pesticides were extracted by ethyl acetate...
  85. Son Y, Lee S, Kim S, Jang Y, Chun J, Lee J. Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation. J Pharm Pharmacol. 2011;63:1309-19 pubmed publisher
    Acteoside is a phenylpropanoid glycoside extracted from the leaves of Rehmannia glutinosa that displays various biological activities...
  86. Tan W, Yu K, Liu Y, Ouyang M, Yan M, Luo R, et al. Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata. Int J Biol Macromol. 2012;50:59-62 pubmed publisher
    ..The mechanism was related to the increase of the storage of hepatic glycogen and the decrease of the accumulation of SUN and BLA. ..
  87. Wang Y, Li X, Li X, Qi J, Sun P, Zhou L. [Analysis of genetic diversity of wild Rehmannia glutinosa by using RAPD and ISSR markers]. Zhongguo Zhong Yao Za Zhi. 2008;33:2591-5 pubmed
    To analyze the genetic diversity of wild Rehmannia glutinosa and evaluate and compare random amplified polymorphic DNA (RAPD) and inter sample sequence repeat (ISSR) for analysis of R. glutinosa accessions...
  88. Du L, Xiang J, Fan J, Li X, Luo L. [Detection of tobacco mosaic virus (TMV) in Rehmannia glutinosa f. hueichingensis by IC-RT-PCR]. Zhongguo Zhong Yao Za Zhi. 2013;38:2092-5 pubmed
    ..and efficient detection method for tobacco mosaic virus (TMV), and provide technical support of TMV detection of Rehmannia glutinosa f. hueichingensis...
  89. Wu Y, Zheng Q, Lu Y, Wang S, Zhu Z. [Identification on Chinese materia medica Radix Rehmanniae preparata by X-ray diffraction Fourier pattern method]. Zhong Yao Cai. 2002;25:318-20 pubmed
    ..The standard X-ray diffraction Fourier Pattern and characteristic diffraction peaks of Radix Rehmanniae Preparata were obtained. This method can be used for identification on Chinese medicinal materia Radix Rehmanniae Preparata. ..
  90. Li H, Chou G, Wang Z, Hu Z. [HPLC determination of acteoside in Radix Rehmanniae]. Zhongguo Zhong Yao Za Zhi. 2006;31:822-4 pubmed
    ..Acteoside showed good linear relationship at the range of 10-500 microg x mL(-1) (r = 0.9990). The average recovery was 100.1%, RS D 3.7%. The proposed method promised to be applicable for the quality control of Radix Rehmanniae. ..
  91. Lv X, Meng Q, Guo X. [Effect of Rehmannia glutinosa water extraction on insulin resistance and gene expression of resistin in type 2 diabetes mellitus rats]. Zhongguo Zhong Yao Za Zhi. 2007;32:2182-4 pubmed
    To investigate the effect of Rehmannia glutinosa water extraction (RGL) on adipose metabolic disorder and gene expression of resistin in type 2 diabetes mellitus rats...
  92. Sun Z, Zhang M, Zhang J, Feng J. Antifungal and cytotoxic activities of the secondary metabolites from endophytic fungus Massrison sp. Phytomedicine. 2011;18:859-62 pubmed publisher
    ..which could be isolated repeatedly from wild Rehmannia glutinosa...