digitalis

Summary

Summary: A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.

Top Publications

  1. Belcastro P. Digitalis: from folklore remedy to valuable drug. J Am Pharm Assoc (Wash). 2002;42:857 pubmed
  2. Sales E, Nebauer S, Arrillaga I, Segura J. Cryopreservation of Digitalis obscura selected genotypes by encapsulation-dehydration. Planta Med. 2001;67:833-8 pubmed
    Shoot-tips from several genotypes of the cardenolide-producing perennial shrub Digitalis obscura L. were successfully cryopreserved using the encapsulation-dehydration technique. Precultivation on MS medium containing 0...
  3. Roca Pérez L, Boluda R, Gavidia I, Pérez Bermúdez P. Seasonal cardenolide production and Dop5betar gene expression in natural populations of Digitalis obscura. Phytochemistry. 2004;65:1869-78 pubmed
    Productivity variations and seasonal fluctuations of cardenolides have been studied in 10 natural populations of Digitalis obscura distributed in three bioclimatic belts. Main cardenolides in D...
  4. Gaffal K, Friedrichs G, El Gammal S. Ultrastructural evidence for a dual function of the phloem and programmed cell death in the floral nectary of Digitalis purpurea. Ann Bot. 2007;99:593-607 pubmed
    The floral nectary of Digitalis purpurea is a transitory organ with stomatal exudation of nectar...
  5. Grindeland J. Inbreeding depression and outbreeding depression in Digitalis purpurea: optimal outcrossing distance in a tetraploid. J Evol Biol. 2008;21:716-26 pubmed publisher
    ..In a population of tetraploid Digitalis purpurea, maternal plants were pollinated with donors at four distances: 0 (self-pollination), 1, 6 and 30 m...
  6. Khan M, CHESNEY J, Laber D, Miller D. Digitalis, a targeted therapy for cancer?. Am J Med Sci. 2009;337:355-9 pubmed publisher
    The clinical benefit of digitalis for patients with heart disease is well established. However, recent studies have also suggested that digitalis has antineoplastic activities at clinically relevant serum concentrations...
  7. Bertol J, Rigotto C, de Padua R, Kreis W, Barardi C, Braga F, et al. Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Res. 2011;92:73-80 pubmed publisher
    ..These results suggest that cardenolides might be promising for future antiviral drug design...
  8. Wu B, Li Y, Yan H, Ma Y, Luo H, Yuan L, et al. Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea. BMC Genomics. 2012;13:15 pubmed publisher
    b>Digitalis purpurea is an important ornamental and medicinal plant. There is considerable interest in exploring its transcriptome.
  9. Gozalpour E, Wittgen H, van den Heuvel J, Greupink R, Russel F, Koenderink J. Interaction of digitalis-like compounds with p-glycoprotein. Toxicol Sci. 2013;131:502-11 pubmed publisher
    b>Digitalis-like compounds (DLCs), or cardiac glycosides, are produced and sequestered by certain plants and animals as a protective mechanism against herbivores or predators...

More Information

Publications131 found, 100 shown here

  1. Küllertz G, Liebau A, Rücknagel P, Schierhorn A, Diettrich B, Fischer G, et al. Stress-induced expression of cyclophilins in proembryonic masses of Digitalis lanata does not protect against freezing/thawing stress. Planta. 1999;208:599-605 pubmed
    Using proembryonic masses (PEMs) of Digitalis lanata Erh...
  2. Müller B, Zumdick A, Schuphan I, Schmidt B. Metabolism of the herbicide glufosinate-ammonium in plant cell cultures of transgenic (rhizomania-resistant) and non-transgenic sugarbeet (Beta vulgaris), carrot (Daucus carota), purple foxglove (Digitalis purpurea) and thorn apple (Datura stramonium. Pest Manag Sci. 2001;57:46-56 pubmed
    ..Similar studies were performed with suspensions of carrot (Daucus carota), purple foxglove (Digitalis purpurea) and thorn apple (Datura stramonium)...
  3. Warren B. Digitalis purpurea. Am J Cardiol. 2005;95:544 pubmed
  4. Ojetti V, Migneco A, Bononi F, De Lorenzo A, Gentiloni Silveri N. Calcium channel blockers, beta-blockers and digitalis poisoning: management in the emergency room. Eur Rev Med Pharmacol Sci. 2005;9:241-6 pubmed
    ..Both support and antidotic therapy are necessary for these potentially unstable patients. Supportive measures and the use of digoxin-specific antibody fragments are first line treatment for digitalis glycoside poisoning.
  5. Garberoglio L, Giustetto C, Wolpert C, Gaita F. Is acquired short QT due to digitalis intoxication responsible for malignant ventricular arrhythmias?. J Electrocardiol. 2007;40:43-6 pubmed
  6. Gavidia I, Tarrio R, Rodriguez Trelles F, Pérez Bermúdez P, Seitz H. Plant progesterone 5beta-reductase is not homologous to the animal enzyme. Molecular evolutionary characterization of P5betaR from Digitalis purpurea. Phytochemistry. 2007;68:853-64 pubmed
    Plants of the genus Digitalis produce cardiac glycosides, i.e. digoxin, which are widely used for congestive heart failure. Progesterone 5beta-reductase (P5betaR) is a key enzyme in the biosynthesis of these natural products...
  7. Thorn A, Egerer Sieber C, Jäger C, Herl V, Müller Uri F, Kreis W, et al. The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductases. J Biol Chem. 2008;283:17260-9 pubmed
    ..of progesterone to 5beta-pregnane-3,20-dione and is a key enzyme in the biosynthetic pathway of cardenolides in Digitalis (foxglove) plants...
  8. Takahashi H, Yoshika M, Komiyama Y, Nishimura M. The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain. Hypertens Res. 2011;34:1147-60 pubmed publisher
    ..intracerebroventricular injection of ouabain increases blood pressure via sympathetic activation, an endogenous digitalis-like factor (EDLF) was thought to regulate cardiovascular system-related functions in the brain, particularly ..
  9. Patil J, Ahire M, Nitnaware K, Panda S, Bhatt V, Kishor P, et al. In vitro propagation and production of cardiotonic glycosides in shoot cultures of Digitalis purpurea L. by elicitation and precursor feeding. Appl Microbiol Biotechnol. 2013;97:2379-93 pubmed publisher
    b>Digitalis purpurea L. (Scrophulariaceae; Foxglove) is a source of cardiotonic glycosides such as digitoxin and digoxin which are commercially applied in the treatment to strengthen cardiac diffusion and to regulate heart rhythm...
  10. López Lázaro M, Palma De La Peña N, Pastor N, Martín Cordero C, Navarro E, Cortés F, et al. Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii. Planta Med. 2003;69:701-4 pubmed
    Recent research has shown the anticancer effects of digitalis compounds suggesting their possible use in medical oncology. Four extracts obtained from the leaves of Digitalis purpurea subsp...
  11. Weidemann H. Na/K-ATPase, endogenous digitalis like compounds and cancer development -- a hypothesis. Front Biosci. 2005;10:2165-76 pubmed
    ..several endogenous steroids, identical or similar to the plant and amphibian steroids, termed here collectively digitalis-like compounds (DLC), have been identified in human tissues...
  12. Herl V, Fischer G, Müller Uri F, Kreis W. Molecular cloning and heterologous expression of progesterone 5beta-reductase from Digitalis lanata Ehrh. Phytochemistry. 2006;67:225-31 pubmed
    A full-length cDNA clone that encodes progesterone 5beta-reductase (5beta-POR) was isolated from Digitalis lanata leaves. The reading frame of the 5beta-POR gene is 1170 nucleotides corresponding to 389 amino acids...
  13. Kummer J, Nair R, Krishnan S. Images in cardiovascular medicine. Bidirectional ventricular tachycardia caused by digitalis toxicity. Circulation. 2006;113:e156-7 pubmed
  14. Nesher M, Shpolansky U, Rosen H, Lichtstein D. The digitalis-like steroid hormones: new mechanisms of action and biological significance. Life Sci. 2007;80:2093-107 pubmed
    b>Digitalis-like compounds (DLC) are a family of steroid hormones synthesized in and released from the adrenal gland...
  15. Herl V, Frankenstein J, Meitinger N, Müller Uri F, Kreis W. Delta 5-3beta-hydroxysteroid dehydrogenase (3 beta HSD) from Digitalis lanata. Heterologous expression and characterisation of the recombinant enzyme. Planta Med. 2007;73:704-10 pubmed
    ..A 3 beta HSD gene was isolated from leaves of Digitalis lanata. It consisted of 870 nucleotides containing a 90 nucleotide long intron...
  16. Butler L, Hay F, Ellis R, Smith R. Post-abscission, pre-dispersal seeds of Digitalis purpurea remain in a developmental state that is not terminated by desiccation ex planta. Ann Bot. 2009;103:785-94 pubmed publisher
    ..This study set out to investigate whether or not there is a critical moisture content, below which drying terminates maturation events for seeds harvested after mass maturity but before dispersal...
  17. Butler L, Hay F, Ellis R, Smith R, Murray T. Priming and re-drying improve the survival of mature seeds of Digitalis purpurea during storage. Ann Bot. 2009;103:1261-70 pubmed publisher
    ..Here a seed lot of Digitalis purpurea L...
  18. Pérez Bermúdez P, García A, Tuñón I, Gavidia I. Digitalis purpurea P5 beta R2, encoding steroid 5 beta-reductase, is a novel defense-related gene involved in cardenolide biosynthesis. New Phytol. 2010;185:687-700 pubmed publisher
    ..and here we investigate the function and regulation of P5 beta R2, a new progesterone 5 beta-reductase gene from Digitalis purpurea. P5 beta R2 cDNA was isolated from a D...
  19. Dos Santos A, Helber I, Antonio E, Franco M, Tucci P. Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction. Int J Cardiol. 2013;167:357-61 pubmed publisher
    The aim of the present study was to evaluate if the influence of digitalis on survival depends on the severity of cardiac dysfunction in heart failure (HF).
  20. Newman L, Feinberg M, LeWine H. Clinical problem-solving. A bitter tale. N Engl J Med. 2004;351:594-9 pubmed
  21. Butler A, Keating R. Old herbal remedies and modern combination therapy. Scott Med J. 2011;56:170-3 pubmed publisher
    ..It is suggested that, in the development of these therapies, it might be possible to learn from the drug 'cocktails' found in plants. ..
  22. de Padua R, Meitinger N, de Souza Filho J, Waibel R, Gmeiner P, Braga F, et al. Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4). Steroids. 2012;77:1373-80 pubmed publisher
    Cell cultures of Digitalis species are known to accept exogenous substrates for biotransformation reactions...
  23. Upshaw J, van Klaveren D, Konstam M, Kent D. Digoxin Benefit Varies by Risk of Heart Failure Hospitalization: Applying the Tufts MC HF Risk Model. Am J Med. 2018;131:676-683.e2 pubmed publisher
    ..It is unknown whether there is heterogeneity of treatment effect for digitalis therapy according to predicted risk of heart failure hospitalization...
  24. Aronson J, Ramachandran M. The diagnosis of art: Alice, the Duchess, Sir John Tenniel, foxgloves, and roses. J R Soc Med. 2007;100:576-8 pubmed
  25. Bjelde B, Miller N, Stillman J, Todgham A. The Role of Oxygen in Determining Upper Thermal Limits in Lottia digitalis under Air Exposure and Submersion. Physiol Biochem Zool. 2015;88:483-93 pubmed publisher
    ..FLT], and temperature sensitivity) was affected by hyperoxia and hypoxia in the finger limpet, Lottia digitalis, under air exposure and submersion...
  26. Goldman P. Herbal medicines today and the roots of modern pharmacology. Ann Intern Med. 2001;135:594-600 pubmed
    The transformation of digitalis from a folk medicine, foxglove, to a modern drug, digoxin, illustrates principles of modern pharmacology that have helped make drugs safer and more effective...
  27. Lopina O. Interaction of Na,K-ATPase catalytic subunit with cellular proteins and other endogenous regulators. Biochemistry (Mosc). 2001;66:1122-31 pubmed
    ..Na,K-ATPase beta- and gamma-subunits, ankyrin, phosphoinositide-3 kinase, and AP-2 protein) and endogenous digitalis-like factors are considered...
  28. Trohler U. Withering's 1785 appeal for caution when reporting on a new medicine. J R Soc Med. 2007;100:155-6 pubmed
  29. Weisse A. A fond farewell to the foxglove? The decline in the use of digitalis. J Card Fail. 2010;16:45-8 pubmed publisher
    Since William Withering's report on the foxglove in 1785, digitalis, in 1 form or another, has remained a mainstay in the treatment of congestive heart failure and as a means of rate control in atrial fibrillation...
  30. Vibe Nielsen S, Petersen R. [Antidigitalis Fab-fragment for treating poisoning from a foxglove plant]. Ugeskr Laeger. 2013;175:1701-2 pubmed
  31. Zeng Y, Quek Y, Kee C, Low M, Bloodworth B, Ge X. Analysis of 32 toxic natural substances in herbal products by liquid chromatography quadrupole linear ion trap mass spectrometry. J Pharm Biomed Anal. 2015;115:169-73 pubmed publisher
    ..The analytes include aconite alkaloids, lobelia alkaloids, solanaceous alkaloids, digitalis steroid glycosides, strychnine, tetrahydropalmatine etc. They werecommonly used in herbal products...
  32. Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R, Hashimoto K. Antiarrhythmic and cardiohemodynamic effects of a novel Ca(2+) channel blocker, AH-1058, assessed in canine arrhythmia models. Eur J Pharmacol. 2000;398:107-12 pubmed
    ..ropeny l]piperidine hydrochloride (AH-1058), were analyzed using the epinephrine-, digitalis- and two-stage coronary ligation-induced canine ventricular arrhythmia models...
  33. Testani J, Brisco M, Tang W, Kimmel S, Tiku Owens A, Forfia P, et al. Potential effects of digoxin on long-term renal and clinical outcomes in chronic heart failure. J Card Fail. 2013;19:295-302 pubmed publisher
    b>Digitalis glycosides are known to improve the hemodynamic and neurohormonal perturbations that contribute to heart failure (HF)-induced renal dysfunction (RD)...
  34. Munkert J, Costa C, Budeanu O, Petersen J, Bertolucci S, Fischer G, et al. Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers. Plant Biol (Stuttg). 2015;17:1113-22 pubmed publisher
    ..Sequence comparison of the catalytic pocket of the P5βR enzymes and homology modelling using Digitalis lanata P5βR (PDB ID: 2V6G) as template highlighted the importance of the hydrophobicity of the binding pocket ..
  35. Erdmann E. The management of heart failure--an overview. Basic Res Cardiol. 2000;95 Suppl 1:I3-7 pubmed
    ..The basis for medical treatment of chronic heart failure depends on diuretics, digitalis, ACE inhibitors, and beta-blockers...
  36. Periyasamy S, Chen J, Cooney D, Carter P, Omran E, Tian J, et al. Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function. Kidney Int. 2001;60:2367-76 pubmed
    ..effects are similar to that seen with ouabain and can be prevented by co-incubation with an antibody fragment to digitalis, which also attenuates the sodium pump inhibitory effect, we suggest that this (these) substance(s) circulating ..
  37. Okano A. Studies on the constituents of Digitalis purpurea L. VII. Enzymatic decomposition of glucodigifucoside. Pharm Bull. 1957;5:279-82 pubmed
  38. Vithayathil M, Edwards M. Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis. BMJ Case Rep. 2016;2016: pubmed publisher
    ..After viewing the images of comfrey and foxglove, it highlighted the possibility of mistaken ingestion of Digitalis, containing the organic forms of cardiac glycosides, such as digoxin and digitoxin...
  39. Gable M, Abdallah S, Najjar S, Liu L, Askari A. Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase. Biochem Biophys Res Commun. 2014;446:1151-4 pubmed publisher
    ..its essential transport function, the sodium pump also activates multiple cell signaling pathways in response to digitalis drugs such as ouabain...
  40. Coiro S, Girerd N, Rossignol P, Bauersachs J, Pitt B, Fay R, et al. Association of digitalis treatment with outcomes following myocardial infarction in patients with heart failure or evidence of left ventricular dysfunction: an analysis from the High-Risk Myocardial Infarction Database Initiative. Clin Res Cardiol. 2017;106:722-733 pubmed publisher
    Contradictory findings have been reported regarding the safety and efficacy of digitalis in patients recovering from acute myocardial infarction (MI)...
  41. Pérez Alonso N, Chong Pérez B, Capote A, Pérez A, Gerth A, Angenon G, et al. Biotechnological Approaches for Biomass and Cardenolide Production in Digitalis purpurea L. Methods Mol Biol. 2016;1391:81-102 pubmed publisher
    b>Digitalis purpurea L. is one of the main economically viable sources of cardenolides (cardiac glycosides) for the pharmaceutical industry...
  42. García Iranzo E, Rodríguez Lucena F, Matoses Chirivella C, García Monsalve A, Murcia López A, Navarro Ruiz A. Pharmacokinetic monitoring of chronic treatment with digoxin from Primary Health Care. Farm Hosp. 2017;41:527-532 pubmed publisher
    ..Of the group 2.25 (13.6%) patientes were hospital admission from emergency department for presenting digitalis intoxication with CSD>2 ng/ml, and 39 (21.3%) patients for low dosing with CSD<0.5 ng/ml...
  43. Li W, Xie S, Tse L, Lagergren J. Digitalis use and lung cancer risk by histological type in men. Int J Cancer. 2017;141:1981-1986 pubmed publisher
    ..Estrogen has been suggested to counteract lung cancer development. We aimed to test the hypothesis that digitalis use decreases lung cancer risk due to its estrogenic and other anticancer properties in men...
  44. Satoh D, Oyama Y, Ishii H. Studies on digitalis glycosides: acetylgitoxin-alpha from gitoxin. Pharm Bull. 1957;5:493 pubmed
  45. Breckenridge A. William Withering's legacy--for the good of the patient. Clin Med (Lond). 2006;6:393-7 pubmed
    The lessons that the physician William Withering learned from his studies of digitalis are still relevant today...
  46. Pozo M, Lachance M, Herrera C. Nectar yeasts of two southern Spanish plants: the roles of immigration and physiological traits in community assembly. FEMS Microbiol Ecol. 2012;80:281-93 pubmed publisher
    ..abilities of all yeast species forming the pool of potential colonizers for two Spanish flowering plants (Digitalis obscura and Atropa baetica)...
  47. Perrone A, Capasso A, Festa M, Kemertelidze E, Pizza C, Skhirtladze A, et al. Antiproliferative steroidal glycosides from Digitalis ciliata. Fitoterapia. 2012;83:554-62 pubmed publisher
    ..classes of spirostane (2,3), pregnane (5-7) and cardenolide (8-10) glycosides, were isolated from the seeds of Digitalis ciliata. Their structures were elucidated by 1D and 2D-NMR experiments as well as ESI-MS analysis...
  48. Metzner M, Ruecknagel K, Knudsen J, Kuellertz G, Mueller Uri F, Diettrich B. Isolation and characterization of two acyl-CoA-binding proteins from proembryogenic masses of Digitalis lanata Ehrh. Planta. 2000;210:683-5 pubmed
    Two acyl-CoA-binding-protein (ACBP) isoforms were isolated from proembryogenic masses of Digitalis lanata Ehrh. by column chromatography and preparative HPLC. The ACBPs had molecular masses of 9926 and 9997 Da, respectively...
  49. Satoh D, Oyama Y, Okumura T. Studies on digitalis glycoside; acetyldigitoxin-alpha from digitoxin. Pharm Bull. 1957;5:627 pubmed
  50. Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H. Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database. J Epidemiol. 2017;27:373-380 pubmed publisher
    ..need for overdose prevention programs that focus on psychiatric patients aged 19-49 years who are prescribed benzodiazepines or barbiturates and on non-psychiatric patients aged ?75 years who are prescribed benzodiazepines or digitalis.
  51. Tesselaar M, Crezee T, Swarts H, Gerrits D, Boerman O, Koenderink J, et al. Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca2+, FOS, and Autophagy-Dependent Pathways. Mol Cancer Ther. 2017;16:169-181 pubmed publisher
    ..Five autophagy-activating compounds, all known as digitalis-like compounds, restored hNIS expression and iodide uptake in thyroid cancer cell lines...
  52. Go K, Bhandary K. Structural studies on the biosides of Digitalis lanata: bisdigitoxosides of digitoxigenin, gitoxigenin and digoxigenin. Acta Crystallogr B. 1989;45 ( Pt 3):306-12 pubmed
    ..This has also been observed in the trioside digoxin. The torsion angle C(13)-C(17)-C(20)-C(22) in the two forms differs by 7 degrees.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  53. Moore W, Taylor L. Extraction and quantitation of digoxin and acetyldigoxin from the Digitalis lanata leaf via near-supercritical methanol-modified carbon dioxide. J Nat Prod. 1996;59:690-3 pubmed
    ..that employs a near-supercritical mixture of CO2 and MeOH to extract the cardiac glycoside, digoxin, from the Digitalis lanata leaf...
  54. Choi D, Lee J, Kim M, Woo E, Kim Y, Kang K. Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation. J Biomed Sci. 2005;12:949-59 pubmed
    ..In the present study, we isolated chrysoeriol from the leaves of Digitalis purpurea (foxglove), and studied its effect on the induction of the inducible nitric oxide synthase (iNOS) gene, ..
  55. Boronnikova S, Kokaeva Z, Gostimskii S, Dribnokhodova O, Tikhomirova N. [Analysis of DNA polymorphism in a relict Uralian species, yellow foxglove (Digitalis grandiflora Mill.), using RAPD and ISSR markers]. Genetika. 2007;43:653-9 pubmed
    Genetic polymorphism of the Uralian relict plant species, yellow foxglove Digitalis grandiflora Mill. (family Scrophulariaceae), was examined using RAPD and ISSR techniques. A total of 149 RAPD and 74 ISSR markers were tested...
  56. Abu Amer N, Priel E, Karlish S, Farfel Z, Mayan H. Hypermagnesuria in Humans Following Acute Intravenous Administration of Digoxin. Nephron. 2017;: pubmed publisher
    Hypomagnesemia is a known predisposing condition for the appearance of digitalis toxicity...
  57. Adamczyk M, Grote J. Efficient synthesis of 3-aminodigoxigenin and 3-aminodigitoxigenin probes. Bioorg Med Chem Lett. 1999;9:771-4 pubmed
    ..Labeling of the pure amines resulted in good yields of the isomerically pure probes. ..
  58. Kwon H, Sim H, Lee S, Lee Y, Park Y, Hong S. HPLC method validation for Digitalis and its analogue by pulsed amperometric detection. J Pharm Biomed Anal. 2011;54:217-21 pubmed publisher
    ..The linear regression coefficient was 0.9962-0.9998 for concentrations of 1-25 ?g/mL. Cardiac glycosides in the Digitalis purpurea leaf displayed intra- and inter-day precisions (RSDs) of <9.30% and average recoveries of 98.63-99...
  59. Wu Z, Awaji T, Motomura S, Hashimoto K. [Effects of a new antiarrhythmic drug, KW-3407, on canine ventricular arrhythmia models]. Nihon Yakurigaku Zasshi. 1992;100:117-26 pubmed
    ..5 fumarate, were examined. To evaluate antiarrhythmic effects, two-stage coronary ligation-, digitalis- and adrenaline-induced spontaneously occurring arrhythmias were used...
  60. Kempf T, Bavendiek U, Bauersachs J. [New pharmacologic therapies for chronic heart failure]. Internist (Berl). 2017;58:990-999 pubmed publisher
    ..Whether digitalis affects the prognosis in heart failure remains unclear; however, serum concentration should be targeted at the ..
  61. Furberg C, Vittinghoff E, Davidson M, Herrington D, Simon J, Wenger N, et al. Subgroup interactions in the Heart and Estrogen/Progestin Replacement Study: lessons learned. Circulation. 2002;105:917-22 pubmed
    ..The findings are discussed in the context of known mechanisms of action and prior scientific knowledge. Use of digitalis and history of myocardial infarction emerged as 2 possible modifiers of the effect of hormone therapy during the ..
  62. Ergin A, Eryol N, Unal S, Deliceo A, Topsakal R, Seyfeli E. Epidemiological and pharmacological profile of congestive heart failure at Turkish academic hospitals. Anadolu Kardiyol Derg. 2004;4:32-8 pubmed
    ..During hospitalization, angiotensin converting enzyme (ACE) inhibitors were used by 77%, diuretics by 95%, digitalis by 76%, nitrate by 85%, beta-blockers by 3%, aspirin by 86%, anticoagulants by 44%, Ca antagonist by 10%, ..
  63. Simpson R. Assessing the safety of drugs through observational research. Heart. 2008;94:129-30 pubmed publisher
  64. Peng M, Yang M, Ding Y, Yu L, Deng Y, Lai W, et al. Mechanism of endogenous digitalis-like factor?induced vascular endothelial cell damage in patients with severe preeclampsia. Int J Mol Med. 2018;41:985-994 pubmed publisher
    Although endogenous digitalis?like factor (EDLF) is associated with the development of various physical disorders, the role in preeclampsia remains unclear...
  65. Xie X, Zhao S. [Congestive heart failure and paraoxonase]. Hunan Yi Ke Da Xue Xue Bao. 2002;27:157-8 pubmed
    ..The PON activity of patients with congestive heart failure significantly decreases. ..
  66. Gobbini M, Cerri A. Digitalis-like compounds: the discovery of the O-aminoalkyloxime group as a very powerful substitute for the unsaturated gamma-butyrolactone moiety. Curr Med Chem. 2005;12:2343-55 pubmed
    b>Digitalis compounds are used in the treatment of congestive heart failure as positive inotropic agents; their action is mainly due to the inhibition of the Na(+),K(+)-ATPase...
  67. Usai M, Atzei A, Marchetti M. Cardenolides content in wild Sardinian Digitalis purpurea L. populations. Nat Prod Res. 2007;21:798-804 pubmed
    In order to quantify the amounts of digitoxigenin and gitoxigenin in wild Sardinian Digitalis purpurea L. an easy extraction method and an high performance liquid chromatography (HPLC) analytical technique have been set up...
  68. Benli M, Yigit N, Geven F, Güney K, Bingol U. Antimicrobial activity of endemic Digitalis lamarckii Ivan from Turkey. Indian J Exp Biol. 2009;47:218-21 pubmed
    ..5 mg/ml. The minimum bactericidal concentration (MBC) of B. subtilis, S. aureus, and L. monocytogenes was calculated to be > or = 199.5 mg/ml, and MBC value for Shigella was calculated as > or = 399 mg/ml. ..
  69. Pollehn T, Brady W, Perron A. Electrocardiographic ST segment depression. Am J Emerg Med. 2001;19:303-9 pubmed
    ..events, such as left bundle branch block (LBBB), left ventricular hypertrophy (LVH), and those with therapeutic digitalis levels...
  70. Johansson S, Goransson U, Luijendijk T, Backlund A, Claeson P, Bohlin L. A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products. J Nat Prod. 2002;65:32-41 pubmed
    ..Of the tested extracts, 41% inhibited pNA formation more than 60%, and 3% stimulated formation. The extract of Digitalis purpurea enhanced pNA formation, and digitoxin, the active compound, was isolated and identified...
  71. Ventura H. Historical vignettes in heart failure. History of heart failure. Congest Heart Fail. 2004;10:203 pubmed
  72. Fukuda K, Handa S, Ogawa S, Nakamura Y, Kawamura Y. [How to select newly-developed oral inotropic agents: an evaluation based on their effects on heart rate and arrhythmias]. J Cardiol. 1990;20:755-65 pubmed
    ..It was concluded that not only the severity of heart failure but the chronotropic and arrhythmogenic effects should be considered when choosing inotropic agents...
  73. Levy P, Dubois Rande J, Cohen Solal A, Levy E. [Economic study of carvedilol in heart failure. A cost effectiveness study in France]. Arch Mal Coeur Vaiss. 2001;94:166-70 pubmed
    ..out in the USA on 1094 patients showed that Carvedilol, associated with the usual bitherapy and eventually with digitalis, reduced the mortality and number of hospital admissions of patients with cardiac failure...
  74. Maffe S, Cucchi L, Zenone F, Bertoncelli C, Beldì F, Colombo M, et al. Digitalis must be banished from the table: a rare case of acute accidental Digitalis intoxication of a whole family. J Cardiovasc Med (Hagerstown). 2009;10:727-32 pubmed publisher
    Advanced Digitalis intoxication is a rare event, mainly associated with overdose in patients with Digitalis therapy...
  75. Stuhlemmer U, Haussmann W, Milek F, Kreis W, Reinhard E. 3 alpha-Hydroxysteroid-5 beta-oxidoreductase in tissue cultures of Digitalis lanata. Z Naturforsch C. 1993;48:713-21 pubmed
    ..or 5 beta-pregnan-3 beta-ol-20-one, were administered to light- or dark-grown shoot cultures of Digitalis lanata...
  76. González Andrés V. [Systematic review of the effectiveness and indications of antidigoxin antibodies in the treatment of digitalis intoxication]. Rev Esp Cardiol. 2000;53:49-58 pubmed
    ..There are two types of digitalis intoxication: one that appears as a complication of the treatment with digitalis, and the other as a result of ..
  77. Kudo M, Watt R, Moffat A. Rapid identification of Digitalis purpurea using near-infrared reflectance spectroscopy. J Pharm Pharmacol. 2000;52:1271-7 pubmed
    Glycosides from Digitalis are widely used for the treatment of various cardiac conditions. The potential for near-infrared (NIR) spectroscopy as a technique for the rapid identification of Digitalis purpurea was studied...
  78. Takahara A, Hirasawa A, Dohmoto H, Shoji M, Yoshimoto R, Sugiyama A, et al. In vivo antiarrhythmic profile of AP-792 assessed in different canine arrhythmia models. Jpn J Pharmacol. 2001;87:21-6 pubmed
    ..hydrochloride, were analyzed using the epinephrine-, digitalis- and two-stage coronary ligation-induced canine ventricular arrhythmia models...
  79. Dyer S. Plant exposures: wilderness medicine. Emerg Med Clin North Am. 2004;22:299-313, vii pubmed
    ..This article discusses poisonous plants, the symptoms that might arise if they are ingested, and the treatments that should be administered to patients...
  80. Hass D, Kozuch P, Brandt L. Pharmacologically mediated colon ischemia. Am J Gastroenterol. 2007;102:1765-80 pubmed
    ..The aim of this paper is to highlight this often unrecognized cause of CI, thereby helping physicians to be aware of the association, to recognize its occurrence promptly, and to possibly reduce morbidity and mortality. ..
  81. Warrell D. Researching nature's venoms and poisons. Trans R Soc Trop Med Hyg. 2009;103:860-6 pubmed publisher
    ..Antivenom rapidly restored haemostatic function but failed to correct other effects of venom toxins incurred during the 3h before he could be treated. ..
  82. Hayamizu K, Morimoto S, Nonaka M, Hoka S, Sasaguri T. Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca2+ transients. Arch Biochem Biophys. 2018;637:40-47 pubmed publisher
    ..These results suggest that QCT exerts a cardiotonic action in vivo at least, in part, through digitalis-like enhancement of CaT by itself and its metabolite tamarixetin.
  83. Tesselaar M, Crezee T, Schuurmans I, Gerrits D, Nagarajah J, Boerman O, et al. Digitalislike Compounds Restore hNIS Expression and Iodide Uptake Capacity in Anaplastic Thyroid Cancer. J Nucl Med. 2018;59:780-786 pubmed publisher
  84. Abarquez R. The old but reliable digitalis: persistent concerns and expanded indications. Int J Clin Pract. 2001;55:108-14 pubmed
    b>Digitalis has been an old but reliable drug for 240 years. Concerns regarding its clinical indications and benefits still exist in the absence of a reduction in all-cause mortality...
  85. Hassapoyannes C, Easterling B, Chavda K, Chavda K, Movahed M, Welch G. The effect of chronic digitalization on pump function in systolic heart failure. Eur J Heart Fail. 2001;3:593-9 pubmed
    ..lt; or =45%) participated from our institution in a multi-center, chronic, randomized, double-blind study of digitalis vs. placebo...
  86. Satoh D, Wada T, Ishii H, Oyama Y, Okumura T. Studies on digitalis glycosides. VII. Gitoroside, digitalonin, and gitoxin pentaacetate. Pharm Bull. 1957;5:253-5 pubmed
  87. Dietzsch A, Stanley D, Stout J. Relative abundance of an invasive alien plant affects native pollination processes. Oecologia. 2011;167:469-79 pubmed publisher
    ..and alien pollen deposition, fruit and seed set were measured in a self-compatible native focal plant, Digitalis purpurea, and compared between field sites that contained different relative abundances of R. ponticum...
  88. Carroll J, Seely E, Tao Q, Graves S. Digitalis-like factor response to hyperinsulinemia accompanying a euglycemic hyperinsulinemic clamp or oral glucose tolerance test. Life Sci. 2001;69:829-37 pubmed
    ..An endogenous sodium pump inhibitor or digitalis-like factor (DLF) has been proposed as a hypertensive agent and its plasma concentrations are elevated in ..
  89. Shpak C, Hiller R, Shpak B, Khananshvili D. The endogenous inhibitor of NCX1 does not resemble the properties of digitalis compound. Biochem Biophys Res Commun. 2003;308:114-9 pubmed
    ..data, it is concluded that the endogenous inhibitor of NCX1 does not resemble the targeting properties of digitalis like compound...
  90. Oh J, Lee J, Han S, Moon Y, Kim Y, Woo E, et al. Effects of phenylethanoid glycosides from Digitalis purpurea L. on the expression of inducible nitric oxide synthase. J Pharm Pharmacol. 2005;57:903-10 pubmed
    ..glycosides (purpureaside A, desrhamnosyl acteoside, calceolarioside B and plantainoside D) from the leaves of Digitalis purpurea (foxglove)...
  91. Rossner S. William Withering (1741-1799). Obes Rev. 2006;7:301 pubmed
  92. Lockie T, Willcocks M, Harrington D. An unusual case of atrioventricular heart block in a young vegan. Int J Cardiol. 2008;125:e12-3 pubmed