vitex

Summary

Summary: A genus of trees in the Lamiaceae family containing assorted flavonoids with possible analgesic and antineoplastic properties. The fruit of these trees is used in herbal preparations.

Top Publications

  1. Chandramu C, Manohar R, Krupadanam D, Dashavantha R. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother Res. 2003;17:129-34 pubmed
    ..3), and ursolic acid (2beta-hydroxyurs-12-en-28-oic acid) (4), were isolated for the first time from leaves of Vitex negundo L...
  2. Dharmasiri M, Jayakody J, Galhena G, Liyanage S, Ratnasooriya W. Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo. J Ethnopharmacol. 2003;87:199-206 pubmed
    ..study confirmed the oral anti-inflammatory, analgesic and antihistamine properties of mature fresh leaves (MFL) of Vitex negundo L. (Verbenaceae) claimed in the Ayurveda medicine by orally treating a water extract of the leaves to rats...
  3. Tandon V, Gupta R. An experimental evaluation of anticonvulsant activity of Vitex-negundo. Indian J Physiol Pharmacol. 2005;49:199-205 pubmed
    ..rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract...
  4. Rooban B, Sasikala V, Sahasranamam V, Abraham A. Vitex negundo modulates selenite-induced opacification and cataractogensis in rat pups. Biol Trace Elem Res. 2010;138:282-92 pubmed publisher
    ..The goal of this study was to determine the efficacy of Vitex negundo in modulating the selenite-induced oxidative stress in vivo model...
  5. Hu Y, Hou T, Zhang Q, Xin H, Zheng H, Rahman K, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007;59:1307-12 pubmed
    The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-..
  6. Dongmo A, Azebaze A, Donfack F, Dimo T, Nkeng Efouet P, Devkota K, et al. Pentacyclic triterpenoids and ceramide mediate the vasorelaxant activity of Vitex cienkowskii via involvement of NO/cGMP pathway in isolated rat aortic rings. J Ethnopharmacol. 2011;133:204-12 pubmed publisher
    b>Vitex cienkowskii Kotschy & Peyritsch is a deciduous tree, prescribed by Cameroonian traditional healers as one of the most popular plant widely used in many disorders including cardiovascular diseases...
  7. Ahmad B, Azam S, Bashir S, Khan I, Adhikari A, Choudhary M. Anti-inflammatory and enzyme inhibitory activities of a crude extract and a pterocarpan isolated from the aerial parts of Vitex agnus-castus. Biotechnol J. 2010;5:1207-15 pubmed publisher
    ..benzofuro [3,2-c][1,3]dioxolo[4,5-g]chromen-9-ol was isolated from the ethyl acetate fraction of Vitex agnus-castus...
  8. Zheng C, Huang B, Han T, Zhang Q, Zhang H, Rahman K, et al. Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds. Pharm Biol. 2010;48:651-8 pubmed publisher
    The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds have been evaluated in several nociceptive mouse models...
  9. Lee S, Lee Y, Kim Y, Kim J, Kang D, Lee H. Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells. Inflammation. 2012;35:584-93 pubmed publisher
    ..Recent pharmacological studies have demonstrated that vitexicarpin, a flavonoid isolated from Vitex rotundifolia, has anti-inflammatory, antitumor, and analgesic properties...
  10. Sahare K, Anandhraman V, Meshram V, Meshram S, Reddy M, Tumane P, et al. Anti-microfilarial activity of methanolic extract of Vitex negundo and Aegle marmelos and their phytochemical analysis. Indian J Exp Biol. 2008;46:128-31 pubmed
    In the present study, methanolic extracts of roots of Vitex negundo L. and extracts of leaves of Vitex negundo L., Ricinus communis L. and Aegle marmelos Corr...

Detail Information

Publications65

  1. Chandramu C, Manohar R, Krupadanam D, Dashavantha R. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother Res. 2003;17:129-34 pubmed
    ..3), and ursolic acid (2beta-hydroxyurs-12-en-28-oic acid) (4), were isolated for the first time from leaves of Vitex negundo L...
  2. Dharmasiri M, Jayakody J, Galhena G, Liyanage S, Ratnasooriya W. Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo. J Ethnopharmacol. 2003;87:199-206 pubmed
    ..study confirmed the oral anti-inflammatory, analgesic and antihistamine properties of mature fresh leaves (MFL) of Vitex negundo L. (Verbenaceae) claimed in the Ayurveda medicine by orally treating a water extract of the leaves to rats...
  3. Tandon V, Gupta R. An experimental evaluation of anticonvulsant activity of Vitex-negundo. Indian J Physiol Pharmacol. 2005;49:199-205 pubmed
    ..rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract...
  4. Rooban B, Sasikala V, Sahasranamam V, Abraham A. Vitex negundo modulates selenite-induced opacification and cataractogensis in rat pups. Biol Trace Elem Res. 2010;138:282-92 pubmed publisher
    ..The goal of this study was to determine the efficacy of Vitex negundo in modulating the selenite-induced oxidative stress in vivo model...
  5. Hu Y, Hou T, Zhang Q, Xin H, Zheng H, Rahman K, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007;59:1307-12 pubmed
    The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-..
  6. Dongmo A, Azebaze A, Donfack F, Dimo T, Nkeng Efouet P, Devkota K, et al. Pentacyclic triterpenoids and ceramide mediate the vasorelaxant activity of Vitex cienkowskii via involvement of NO/cGMP pathway in isolated rat aortic rings. J Ethnopharmacol. 2011;133:204-12 pubmed publisher
    b>Vitex cienkowskii Kotschy & Peyritsch is a deciduous tree, prescribed by Cameroonian traditional healers as one of the most popular plant widely used in many disorders including cardiovascular diseases...
  7. Ahmad B, Azam S, Bashir S, Khan I, Adhikari A, Choudhary M. Anti-inflammatory and enzyme inhibitory activities of a crude extract and a pterocarpan isolated from the aerial parts of Vitex agnus-castus. Biotechnol J. 2010;5:1207-15 pubmed publisher
    ..benzofuro [3,2-c][1,3]dioxolo[4,5-g]chromen-9-ol was isolated from the ethyl acetate fraction of Vitex agnus-castus...
  8. Zheng C, Huang B, Han T, Zhang Q, Zhang H, Rahman K, et al. Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds. Pharm Biol. 2010;48:651-8 pubmed publisher
    The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds have been evaluated in several nociceptive mouse models...
  9. Lee S, Lee Y, Kim Y, Kim J, Kang D, Lee H. Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells. Inflammation. 2012;35:584-93 pubmed publisher
    ..Recent pharmacological studies have demonstrated that vitexicarpin, a flavonoid isolated from Vitex rotundifolia, has anti-inflammatory, antitumor, and analgesic properties...
  10. Sahare K, Anandhraman V, Meshram V, Meshram S, Reddy M, Tumane P, et al. Anti-microfilarial activity of methanolic extract of Vitex negundo and Aegle marmelos and their phytochemical analysis. Indian J Exp Biol. 2008;46:128-31 pubmed
    In the present study, methanolic extracts of roots of Vitex negundo L. and extracts of leaves of Vitex negundo L., Ricinus communis L. and Aegle marmelos Corr...
  11. Gallo M, Vieira P, Fernandes J, da Silva M, Salimena Pires F. Compounds from Vitex polygama active against kidney diseases. J Ethnopharmacol. 2008;115:320-2 pubmed
    b>Vitex polygama Cham. (Lamiaceae, formerly Verbenaceae) is a familiar Brazilian species popularly known as Tarumã whose leaf tea has been used by population to treat kidney diseases...
  12. Zanatta L, de Sousa E, Cazarolli L, Junior A, Pizzolatti M, Szpoganicz B, et al. Effect of crude extract and fractions from Vitex megapotamica leaves on hyperglycemia in alloxan-diabetic rats. J Ethnopharmacol. 2007;109:151-5 pubmed
    The effect of the crude extract, ethyl acetate and n-butanol fractions from Vitex megapotamica (Spreng) Moldenke on glycemia was investigated in diabetic rats...
  13. Liu J, Burdette J, Sun Y, Deng S, Schlecht S, Zheng W, et al. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004;11:18-23 pubmed
    A methanol extract of chaste-tree berry (Vitex agnus-castus L.) was tested for its ability to displace radiolabeled estradiol from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta)...
  14. Kiuchi F, Matsuo K, Ito M, Qui T, Honda G. New norditerpenoids with trypanocidal activity from Vitex trifolia. Chem Pharm Bull (Tokyo). 2004;52:1492-4 pubmed
    Trypanocidal constituents of the fruits of Vitex trifolia were investigated...
  15. Singh N, Jyoti -, Vemu B, Nandi A, Singh H, Kumar R, et al. Acaricidal activity of Cymbopogon winterianus, Vitex negundo and Withania somnifera against synthetic pyrethroid resistant Rhipicephalus (Boophilus) microplus. Parasitol Res. 2014;113:341-50 pubmed publisher
    ..was used to assess the acaricidal activity of aqueous and ethanolic extracts of leaves of Cymbopogon winterianus, Vitex negundo, and Withania somnifera along with roots of V. negundo against the SP resistant engorged females of R. (B...
  16. Rooban B, Lija Y, Biju P, Sasikala V, Sahasranamam V, Abraham A. Vitex negundo attenuates calpain activation and cataractogenesis in selenite models. Exp Eye Res. 2009;88:575-82 pubmed publisher
    ..Our present study focuses on the isolation of flavonoids from Vitex negundo and to assess its efficacy in preventing these changes in the lens of selenite-induced cataract models...
  17. Haq R, Shah A, Khan A, Ullah Z, Khan H, Khan R, et al. Antitussive and toxicological evaluation of Vitex negundo. Nat Prod Res. 2012;26:484-8 pubmed publisher
    b>Vitex negundo Linn. (Verbenaceae) is used in traditional medical system for respiratory disorders. This study was carried out to investigate its cough-relieving potential. The antitussive effect of the butanolic extract of V...
  18. Sridhar C, Rao K, Subbaraju G. Flavonoids, triterpenoids and a lignan from Vitex altissima. Phytochemistry. 2005;66:1707-12 pubmed
    ..in addition to several known triterpene acids and flavonoids from the ethyl acetate extractives of the leaves of Vitex altissima...
  19. van Die M, Burger H, Teede H, Bone K. Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med. 2013;79:562-75 pubmed publisher
    b>Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice...
  20. Kobayakawa J, Sato Nishimori F, Moriyasu M, Matsukawa Y. G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). Cancer Lett. 2004;208:59-64 pubmed
    ..Further examinations are required to confirm that casticin is an antitumor drug for specific cancers with low toxicity...
  21. Das S, Parveen S, Kundra C, Pereira B. Reproduction in male rats is vulnerable to treatment with the flavonoid-rich seed extracts of Vitex negundo. Phytother Res. 2004;18:8-13 pubmed
    A partially purified flavonoid-rich extract was prepared from the seed of Vitex negundo. The effect of this extract on the reproductive system of male rats was investigated at four different concentrations...
  22. Jarry H, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V. Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. Planta Med. 2003;69:945-7 pubmed
    Recent cell culture experiments indicated that extracts of Vitex agnus-castus (VAC) may contain yet unidentified phytoestrogens. Estrogenic actions are mediated via estrogen receptors (ER)...
  23. Huang H, Chang T, Chang L, Wang H, Yih K, Hsieh W, et al. Inhibition of melanogenesis versus antioxidant properties of essential oil extracted from leaves of Vitex negundo Linn and chemical composition analysis by GC-MS. Molecules. 2012;17:3902-16 pubmed publisher
    ..negundo Linn leaves decreased melanin production in B16F10 melanoma cells and showed potent antioxidant activities. The essential oil can thereby serve as an inhibitor of melanin synthesis and could also act as a natural antioxidant...
  24. Wang H, Cai B, Cui C, Zhang D, Yang B. [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway]. Yao Xue Xue Bao. 2005;40:27-31 pubmed
    ..To investigate the inhibitory effect of vitexicarpin on the proliferation of human cancer cells and its mechanism of action...
  25. Ohyama K, Akaike T, Hirobe C, Yamakawa T. Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth. Biol Pharm Bull. 2003;26:10-8 pubmed
    A crude extract was prepared with ethanol from dried ripened Vitex agnus-castus fruits growing in Israel (Vitex extract)...
  26. Karunamoorthi K, Ramanujam S, Rathinasamy R. Evaluation of leaf extracts of Vitex negundo L. (Family: Verbenaceae) against larvae of Culex tritaeniorhynchus and repellent activity on adult vector mosquitoes. Parasitol Res. 2008;103:545-50 pubmed publisher
    Petroleum ether (60-80 degrees C) extracts of the leaves of Vitex negundo (Verbenaceae) were evaluated for larvicidal activity against larval stages of Culex tritaeniorhynchus in the laboratory. Larvae of C...
  27. Hu Y, Hou T, Xin H, Zhang Q, Zheng H, Rahman K, et al. Estrogen-like activity of volatile components from Vitex rotundifolia L. Indian J Med Res. 2007;126:68-72 pubmed
    The fruits of Vitex rotundifolia L. are used as a traditional medicine in China. Dried fruits of V. rotundifolia (rich in essential oils) have been known to show strong estrogenic activity...
  28. Ling T, Ling W, Chen Y, Wan X, Xia T, Du X, et al. Antiseptic activity and phenolic constituents of the aerial parts of Vitex negundo var. cannabifolia. Molecules. 2010;15:8469-77 pubmed publisher
    ..4), and isovitexin (5), along with ?-tocoquinone (3) and ?-sitosterol (6) were isolated from the aerial parts of Vitex negundo var. cannabifolia. The isolation was performed using bio-assay tracking experiments...
  29. Azhar Ul Haq -, Malik A, Anis I, Khan S, Ahmed E, Ahmed Z, et al. Enzyme inhibiting lignans from Vitex negundo. Chem Pharm Bull (Tokyo). 2004;52:1269-72 pubmed
    ..The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase...
  30. Gorkow C, Wuttke W, März R. [Effectiveness of Vitex agnus-castus preparations]. Wien Med Wochenschr. 2002;152:364-72 pubmed
    ..The success rates on fertility disorders should be confirmed in controlled double-blind studies (10, 33, 34)...
  31. Webster D, He Y, Chen S, Pauli G, Farnsworth N, Wang Z. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol. 2011;81:170-7 pubmed publisher
    b>Vitex agnus-castus (VAC) has been used since ancient Greek times and has been shown clinically to be effective for the treatment of pre-menstrual syndrome. However, its mechanism of action has only been partially determined...
  32. van Die M, Bone K, Burger H, Reece J, Teede H. Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: findings from a subpopulation analysis. J Altern Complement Med. 2009;15:1045-8 pubmed publisher
  33. Chopin Lucks B. Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154]. Complement Ther Nurs Midwifery. 2003;9:157-60 pubmed
    The first trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus for menopausal balance was conducted in the summer of 2000 by the author...
  34. Zamani M, Neghab N, Torabian S. Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome. Acta Med Iran. 2012;50:101-6 pubmed
    ..In this study the therapeutic effect of Vitex agnus castus on women who had the PMS, in comparison with placebo, were investigated...
  35. Ladeji O, Udoh F, Okoye Z. Activity of aqueous extract of the bark of Vitex doniana on uterine muscle response to drugs. Phytother Res. 2005;19:804-6 pubmed
    The activity of Vitex doniana on the uterine muscle response was investigated. The bark of Vitex doniana was extracted in boiled water at 100 degrees C, and the extracted solution filtered and centrifuged with refrigeration...
  36. Azhar Ul Haq -, Malik A, Khan M, Anwar Ul Haq -, Khan S, Ahmad A, et al. Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship. Phytomedicine. 2006;13:255-60 pubmed
    Phytochemical investigation of the methanol extract of Vitex negundo afforded eight lignans; negundin A 1, negundin B 2, 6-hydroxy-4-(4-hydroxy-3-methoxy)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-naphthaledehyde 3, vitrofolal E 4, (+)-..
  37. Matsui M, Kumar Roine S, Darius H, Chinain M, Laurent D, Pauillac S. Characterisation of the anti-inflammatory potential of Vitex trifolia L. (Labiatae), a multipurpose plant of the Pacific traditional medicine. J Ethnopharmacol. 2009;126:427-33 pubmed publisher
    b>Vitex trifolia L. (Labiatae) is a plant commonly employed against Ciguatera Fish Poisoning (CFP) in the Pacific region...
  38. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003;18:191-5 pubmed
    Clinical trials have demonstrated that serotonin reuptake inhibitors (SRIs) and the extract of Vitex agnus castus are effective for the treatment of premenstrual dysphoric disorder (PMDD)...
  39. van Die M, Burger H, Bone K, Cohen M, Teede H. Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial. Menopause. 2009;16:156-63 pubmed publisher
    To evaluate the effectiveness of a phytotherapeutic intervention comprising a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) in the management of menopausal symptoms.
  40. Hajdú Z, Hohmann J, Forgo P, Martinek T, Dervarics M, Zupko I, et al. Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. Phytother Res. 2007;21:391-4 pubmed
    From the n-hexane fraction of the fruits of Vitex agnus-castus, two labdane-type diterpenes, vitetrifolin B and C, were isolated by means of multiple chromatographic separations, together with the previously identified rotundifuran, ..
  41. Ondo J, Lekana Douki J, Bongui J, Zang Edou E, Zatra R, Toure Ndouo F, et al. In vitro antiplasmodial activity and cytotoxicity of extracts and fractions of Vitex madiensis, medicinal plant of Gabon. Trop Med Int Health. 2012;17:316-21 pubmed publisher
    b>Vitex madiensis Oliv. (Lamiaceae) is traditionally used to treat malaria symptoms in Haut-Ogooué, Gabon...
  42. Gupta R, Tandon V. Antinociceptive activity of Vitex-negundo Linn leaf extract. Indian J Physiol Pharmacol. 2005;49:163-70 pubmed
    ..acid induced writhing in mice were employed to study the antinociceptive activity of ethanolic leaf extract of Vitex-negundo (VN) (100, 250 and 500 mg/kg, p.o)...
  43. Kannathasan K, Senthilkumar A, Venkatesalu V, Chandrasekaran M. Larvicidal activity of fatty acid methyl esters of Vitex species against Culex quinquefasciatus. Parasitol Res. 2008;103:999-1001 pubmed publisher
    The larvicidal activity of fatty acid methyl ester (FAME) extracts of Vitex altissima, Vitex negundo and Vitex trifolia was studied against early fourth-instar larvae of Culex quinquefasciatus...
  44. Kannathasan K, Senthilkumar A, Venkatesalu V. Mosquito larvicidal activity of methyl-p-hydroxybenzoate isolated from the leaves of Vitex trifolia Linn. Acta Trop. 2011;120:115-8 pubmed publisher
    ..In the present study, a crystalline compound methyl-p-hydroxybenzoate was isolated from the methanol extract of Vitex trifolia leaves and it was identified by (1)H and (13)C NMR and single crystal X-ray diffractometer...
  45. Webster D, Lu J, Chen S, Farnsworth N, Wang Z. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006;106:216-21 pubmed
    The dried ripe fruit of Vitex agnus-castus L. (VAC) is widely used for the treatment of premenstrual syndrome (PMS)...
  46. van Die M, Burger H, Teede H, Bone K. Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. J Altern Complement Med. 2009;15:853-62 pubmed publisher
    The origin of the current practice of administering Vitex agnus-castus in menopause-related complaints is uncertain, but appears to be relatively recent...
  47. Daniele C, Thompson Coon J, Pittler M, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005;28:319-32 pubmed
    b>Vitex agnus castus L. (VAC) [Verbenaceae] is a deciduous shrub that is native to Mediterranean Europe and Central Asia...
  48. Sehmisch S, Boeckhoff J, Wille J, Seidlova Wuttke D, Rack T, Tezval M, et al. Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation. Phytother Res. 2009;23:851-8 pubmed publisher
    ..The groups either received soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks...
  49. Sena Filho J, Duringer J, Maia G, Tavares J, Xavier H, da Silva M, et al. Ecdysteroids from Vitex species: distribution and compilation of their 13C-NMR spectral data. Chem Biodivers. 2008;5:707-13 pubmed publisher
    ..The present work describes the distribution of ecdysteroids in plants from the genus Vitex from a review of previous work on seventeen Vitex species...
  50. Tandon V, Gupta R. Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs. Indian J Med Res. 2006;124:447-50 pubmed
    Leaves of Vitex negundo (VN) have been investigated for their antiinflammatory activity in past, including its mechanism of action. However, nobody has evaluated its potential role as an adjuvant with standard anti-inflammatory therapy...
  51. He Z, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, et al. Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas. 2009;63:99-103 pubmed publisher
    ..To investigate the efficacy and safety of VAC BNO 1095 extract in Chinese women suffering from moderate to severe premenstrual syndrome (PMS)...
  52. Alam M, Gomes A. Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts. J Ethnopharmacol. 2003;86:75-80 pubmed
    The methanolic root extracts of Vitex negundo Linn. and Emblica officinalis Gaertn. were explored for the first time for antisnake venom activity. The plant (V. negundo and E...
  53. Weisskopf M, Schaffner W, Jundt G, Sulser T, Wyler S, Tullberg Reinert H. A Vitex agnus-castus extract inhibits cell growth and induces apoptosis in prostate epithelial cell lines. Planta Med. 2005;71:910-6 pubmed
    Extracts of Vitex agnus-castus fruits (VACF) are described to have beneficial effects on disorders related to hyperprolactinemia (cycle disorders, premenstrual syndrome)...
  54. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova Wuttke D. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine. 2003;10:348-57 pubmed
    Extracts of the fruits of chaste tree (Vitex agnus castus = AC) are widely used to treat premenstrual symptoms. Double-blind placebo-controlled studies indicate that one of the most common premenstrual symptoms, i.e...
  55. Tiwari N, Thakur J, Saikia D, Gupta M. Antitubercular diterpenoids from Vitex trifolia. Phytomedicine. 2013;20:605-10 pubmed publisher
    ..for the first time, along with fifteen known compounds, from the hexane soluble fraction of methanolic extract of Vitex trifolia leaves. The structures of these new diterpenoids were elucidated by spectral analysis...
  56. Hu Y, Xin H, Zhang Q, Zheng H, Rahman K, Qin L. Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents. Phytomedicine. 2007;14:668-74 pubmed
    b>Vitex rotundifolia L. is widely distributed along the sea coast of China...
  57. Tasduq S, Kaiser P, Gupta B, Gupta V, Johri R. Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride. World J Gastroenterol. 2008;14:3693-709 pubmed
    ..To evaluate the protective effect of 2'-p-hydroxybenzoylmussaenosidic acid [negundoside (NG), against carbon tetrachloride (CCl(4))-induced toxicity in HuH-7 cells...
  58. Meier B, Berger D, Hoberg E, Sticher O, Schaffner W. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine. 2000;7:373-81 pubmed
    The pharmacological effects of ethanolic Vitex agnus-castus fruit-extracts (especially Ze 440) and various extract fractions of different polarities were evaluated both by radioligand binding studies and by superfusion experiments...
  59. Mehlhorn H, Schmahl G, Schmidt J. Extract of the seeds of the plant Vitex agnus castus proven to be highly efficacious as a repellent against ticks, fleas, mosquitoes and biting flies. Parasitol Res. 2005;95:363-5 pubmed
    ..It was found that a CO2 extract of the seeds of the Mediterranean plant Vitex agnus castus (monk's pepper) can be used as a spray to keep away especially Ixodes ricinus and Rhipicephalus ..
  60. Arif Lodhi M, Iqbal Choudhary M, Malik A, Ahmad S. alpha-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn. J Enzyme Inhib Med Chem. 2008;23:400-5 pubmed
    The lignans (1-8) isolated from the roots of Vitex negundo Linn. were screened against the serine proteases alpha-chymotrypsin, thrombin and prolyl endopeptidase...
  61. Gallo M, Rocha W, da Cunha U, Diogo F, da Silva F, Vieira P, et al. Bioactivity of extracts and isolated compounds from Vitex polygama (Verbenaceae) and Siphoneugena densiflora (Myrtaceae) against Spodoptera frugiperda (Lepidoptera: Noctuidae). Pest Manag Sci. 2006;62:1072-81 pubmed
    The effects of crude extracts, fractions and isolated compounds from Vitex polygama Cham...
  62. Ohyama K, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T. Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress. Int J Biochem Cell Biol. 2005;37:1496-510 pubmed
    We have previously reported that an ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) displays cytotoxic activity against certain kinds of human cancer cell line resulting in the induction of apoptosis...
  63. Diaz F, CHAVEZ D, Lee D, Mi Q, Chai H, Tan G, et al. Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. J Nat Prod. 2003;66:865-7 pubmed
    Bioassay-guided fractionation of the chloroform-soluble extract of the leaves of Vitex negundo led to the isolation of the known flavone vitexicarpin (1), which exhibited broad cytotoxicity in a human cancer cell line panel...
  64. Suksamrarn A, Kumpun S, Kirtikara K, Yingyongnarongkul B, Suksamrarn S. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002;68:72-3 pubmed
    A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark...