scutellaria baicalensis

Summary

Summary: A plant species of the genus Scutellaria, family LAMIACEAE, that contains skullcap flavone and is used in CHINESE HERBAL DRUGS.

Top Publications

  1. Lee S, Kim D, Jung J, Oh J, Park H, Park C, et al. Schizandra chinensis and Scutellaria baicalensis counter stress behaviors in mice. Phytother Res. 2007;21:1187-92 pubmed
    The individual and combined antistress effects of the fruit of Schizandra chinensis and the radix of Scutellaria baicalensis were evaluated using a mouse acute stress model...
  2. Ye F, Xui L, Yi J, Zhang W, Zhang D. Anticancer activity of Scutellaria baicalensis and its potential mechanism. J Altern Complement Med. 2002;8:567-72 pubmed
    b>Scutellaria baicalensis is a widely used Chinese herbal medicine that historically is used in anti-inflammatory and anticancer therapy...
  3. Heo H, Shin Y, Cho W, Choi Y, Kim H, Kwon Y. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. J Ethnopharmacol. 2009;122:20-7 pubmed publisher
    b>Scutellaria baicalensis Georgi (Labiatae) extracts have been used as traditional Korean medicine, to treat cerebral ischemia in addition to bacterial infection and inflammatory diseases...
  4. Kimura Y, Sumiyoshi M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. Eur J Pharmacol. 2011;661:124-32 pubmed publisher
    ..study, we examined the effects of two main flavonoids (wogonin and baicalein) isolated from the roots of Scutellaria baicalensis, a traditional remedy for allergic inflammatory diseases long used in China and Japan, on acute UVB ..
  5. Lin Y, Dai Z, Lin R, Chu K, Chen I, Wu J, et al. Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. Phytomedicine. 2010;17:760-70 pubmed publisher
    Baicalin isolated from Scutellaria baicalensis is a traditional Chinese herbal medicine used for cardiovascular dysfunction. The ionic mechanism of the vasorelaxant effects of baicalin remains unclear...
  6. Xu G, Dou J, Zhang L, Guo Q, Zhou C. Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serum. Biol Pharm Bull. 2010;33:238-43 pubmed
    Baicalein, an extract from Scutellaria baicalensis, was evaluated for its ability to inhibit the influenza virus in vivo...
  7. Jung H, Kim M, Gwak N, Im Y, Lee K, Sohn Y, et al. Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro. J Ethnopharmacol. 2012;141:345-9 pubmed publisher
    b>Scutellaria baicalensis (SB) is one of the most widely used medicinal herbs for the treatment of inflammation. In this study, we investigated the antiallergic effect of SB in vivo and in vitro...
  8. Jianjun J, Huiru D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Nat Prod Res. 2008;22:1410-2 pubmed publisher
    ..In this work, high-purity baicalein was prepared. In the process of preparation, baicalin was obtained from Scutellaria baicalensis Georgi by alkali-solution and acid-isolation methods, and then high-purity baicalein was obtained by ..
  9. Choi Y, Kang O, Park H, Tae J, Kim D, Kang C, et al. Effect of processed Scutellaria baicalensis on dextran sulfate sodium-induced colitis in mice. Int J Mol Med. 2005;16:667-72 pubmed
    b>Scutellaria baicalensis Georgi (Labiatae) has been used in the treatment of inflammatory diseases. Drug processing (Poje) is the process of treating crude drugs by several methods before use...

More Information

Publications87

  1. Hui K, Huen M, Wang H, Zheng H, Sigel E, Baur R, et al. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem Pharmacol. 2002;64:1415-24 pubmed
    ..Its anxiolytic effect was not accompanied by sedative and myorelaxant side-effects typical of BDZs. ..
  2. Hao H, Aixia Y, Lei F, Nancai Y, Wen S. Effects of baicalin on Chlamydia trachomatis infection in vitro. Planta Med. 2010;76:76-8 pubmed publisher
    ..In conclusion, our findings demonstrated that baicalin can effectively inhibit Chlamydia Trachomatis in HeLa cells and therefore can be considered a potential agent for the therapy of infectious diseases caused by C. trachomatis. ..
  3. Lu Y, Joerger R, Wu C. Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. J Agric Food Chem. 2011;59:10934-42 pubmed publisher
    b>Scutellaria baicalensis Georgi (SBG), commonly named Huangqin, showed strong in vitro antimicrobial effects...
  4. Qi Q, Peng J, Liu W, You Q, Yang Y, Lu N, et al. Toxicological studies of wogonin in experimental animals. Phytother Res. 2009;23:417-22 pubmed publisher
    Wogonin, one active ingredient extract from the radix of Scutellaria baicalensis Georgi, is known to possess a broad spectrum of pharmacological, medicinal and therapeutic properties, especially the anticancer activity studied recently...
  5. Ye F, Jiang S, Volshonok H, Wu J, Zhang D. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. Nutr Cancer. 2007;57:100-10 pubmed
    b>Scutellaria baicalensis is a widely used Chinese herbal medicine historically used in antiinflammatory and anticancer therapy...
  6. Boyle S, Doolan P, Andrews C, Reid R. Evaluation of quality control strategies in Scutellaria herbal medicines. J Pharm Biomed Anal. 2011;54:951-7 pubmed publisher
    ..The species Scutellaria baicalensis has been shown to possess anti-inflammatory, anti-viral and anti-tumor properties and is one of the most ..
  7. Yoon S, Lee Y, Park S, Kim H, Bae H, Kim H, et al. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. J Ethnopharmacol. 2009;125:286-90 pubmed publisher
    The root of Scutellaria baicalensis Georgi (Labiatae), also known as Scutellariae Radix, possesses anticancer, antiviral, and anti-inflammatory properties. And it is one of the most widespread herbal remedies used in Oriental medicine...
  8. Hao H, Aixia Y, Dan L, Lei F, Nancai Y, Wen S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. Fitoterapia. 2009;80:448-52 pubmed publisher
    ..Our findings demonstrate that Baicalin can inhibit C. trachomatis effectively and therefore, can be considered as potential agents for therapy of Chlamydia infectious diseases. ..
  9. Kim E, Shim B, Kang S, Jeong G, Lee J, Yu Y, et al. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. J Ethnopharmacol. 2009;126:320-31 pubmed publisher
    A herbal preparation using Scutellaria baicalensis (S. baicalensis) Georgi (Huang Qin, SB) was formulated to effectively protect cancer patients from inflammatory reactions...
  10. Zhang D, Wu J, Ye F, Xue L, Jiang S, Yi J, et al. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res. 2003;63:4037-43 pubmed
    b>Scutellaria baicalensis is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anticancer therapy...
  11. Huan S, Wang K, Yeh S, Lee C, Lin L, Liu D, et al. Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. Molecules. 2012;17:6277-89 pubmed publisher
    ..In TCM, Scutellaria baicalensis is usually used to cure mylabris-induced hematuria...
  12. Murch S, Rupasinghe H, Goodenowe D, Saxena P. A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. Plant Cell Rep. 2004;23:419-25 pubmed
    In vitro manipulation of plant regeneration in the Chinese medicinal species Scutellaria baicalensis Georgi (Huang-qin) resulted in 26 chemically distinct germplasm lines...
  13. Aung H, Dey L, Mehendale S, Xie J, Wu J, Yuan C. Scutellaria baicalensis extract decreases cisplatin-induced pica in rats. Cancer Chemother Pharmacol. 2003;52:453-8 pubmed
    ..In this study, we investigated the effects of Scutellaria baicalensis, an antioxidant herbal medicine, on cisplatin-induced nausea using a rat model...
  14. Yang X, Huang S, Chen J, Song N, Wang L, Zhang Z, et al. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Vaccine. 2010;28:737-43 pubmed publisher
    ..adjuvant effect of aqueous extracts obtained from medicinal herbs of Astragalus membranaceus (Am) and Scutellaria baicalensis GEORGI (Sb) on the immune response to Toxoplasma gondii in the mouse models induced by ultraviolet (UV)-..
  15. Hong T, Jeong M, Zahn M, Fay B, Lee K, Hwangbo H, et al. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. J AOAC Int. 2009;92:785-8 pubmed
    ..This simple method can be completed in an hour for the quality control of Univestin and its raw material, S. baicalensis. The method is sensitive and can detect T. chamaedrys at levels as low as 0.5% (w/w)...
  16. Peng J, Qi Q, You Q, Hu R, Liu W, Feng F, et al. Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. J Ethnopharmacol. 2009;124:257-62 pubmed publisher
    ..9+/-231.4 ngh/ml, while the elimination half-life (t(1/2)) was 1.51+/-0.43 h in dogs treated with 20mg/kg wogonin. Wogonin offered a wide margin of safety and had no organ toxicity for a long time intravenous administration in dogs. ..
  17. Xu F, Li Z, Zheng J, Gee Cheung F, Chan T, Zhu L, et al. The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. J Pharm Sci. 2013;102:4205-11 pubmed publisher
    ..Baicalein (BA), baicalin (BG), and wogonin (WG) are the three major bioactive components of Scutellaria baicalensis. In this study, we evaluated the inhibitory effects of BA, BG, and WG on the cellular uptake of specific ..
  18. Zhang X, Li W, Li W, Ren K, Fan C, Chen Y, et al. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Pharm Biol. 2011;49:256-61 pubmed publisher
    b>Scutellaria baicalensis Georgi (Labiatae) (SbG), one of the fifty fundamental herbs of Chinese herbology, has been reported to have anti-asthmatic, antifungal, antioxidative, and anti-inflammatory activities.
  19. Huang S, Wang C, Yang R, Chu C, Wu H, Pang J. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Phytomedicine. 2010;17:47-54 pubmed publisher
    Crude extract of Scutellaria baicalensis (S. baicalensis) has cytotoxic effect on human myelogenous leukemia cells (HL-60). We invesigated which compound from the crude extract is responsible for the cytotoxic effect on HL-60 cells...
  20. Yu C, Qu F, Mao Y, Li D, Zhen Z, Nass R, et al. Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. Pharm Biol. 2013;51:1228-35 pubmed publisher
    b>Scutellaria baicalensis Georgi (Labiatae) is one of the most commonly used medicinal herbs, especially in traditional Chinese medicine...
  21. Zhen Z, Chang B, Li M, Lian F, Chen L, Dong L, et al. Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats. Am J Chin Med. 2011;39:53-63 pubmed
    ..Dachaihu which has a history of more than 2000 years, has main constituents of Coptis chinensis Franch, Scutellaria baicalensis Georgi, Rheum officinale Baill and Bupleurum chinense DC...
  22. Mo S, Liu W, Chen Y, Luo H, Sun L, Chen X, et al. Ligand- and protein-based modeling studies of the inhibitors of human cytochrome P450 2D6 and a virtual screening for potential inhibitors from the Chinese herbal medicine, Scutellaria baicalensis (Huangqin,Baikal Skullcap). Comb Chem High Throughput Screen. 2012;15:36-80 pubmed
    ..Finally, we screened for potential binders/inhibitors from the Chinese herbal medicine Scutellaria baicalensis (Huangqin, Baikal Skullcap) using the established pharmacophore model for CYP2D6 inhibitors and molecular ..
  23. Ye F, Wang H, Jiang S, Wu J, Shao J, Cheng X, et al. Quality evaluation of commercial extracts of Scutellaria baicalensis. Nutr Cancer. 2004;49:217-22 pubmed
    ..Therefore, chemical analysis alone is inadequate for quality control, and biological assays must be included for botanical products to ensure chemical authenticity as well as pharmacological/biological potency and consistency...
  24. Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson P. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res. 2005;11:3905-14 pubmed
    Botanical preparations are widely used by patients with prostate cancer. Scutellaria baicalensis, a botanical with a long history of medicinal use in China, was a constituent of the herbal mixture PC-SPES, a product that inhibited ..
  25. Wang C, Mehendale S, Calway T, Yuan C. Botanical flavonoids on coronary heart disease. Am J Chin Med. 2011;39:661-71 pubmed
    ..In this article, we will discuss two herbs containing potent flavonoids, Scutellaria baicalensis and grape seed proanthocyanidin, which can potentially offer cardiac protection against ischemic heart ..
  26. Jeong K, Shin Y, Park S, Park J, Kim N, Um J, et al. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. J Biomed Sci. 2011;18:14 pubmed publisher
    ..These findings suggest that SBG, especially high dose, 100 mg/kg, improved the memory impairments significantly and showed antioxidation, antiinflammation and intrinsic caspase-mediated apoptosis effects...
  27. Yim J, Kim Y, Moon S, Cho K, Bae H, Kim J, et al. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull. 2004;27:1580-3 pubmed
    ..These results suggest that the human intestinal microflora enzymes that convert herbal components to their bioactive compounds may be used as selection markers of responders to traditional medicines...
  28. Park K, Park H, Kang S, Nagappan A, Lee D, Kim J, et al. Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. J Ethnopharmacol. 2011;133:634-41 pubmed publisher
    b>Scutellaria baicalensis Georgi is a widely used medicinal herb in several Asian countries including Korea...
  29. Lee Y, Cheng P, Chim L, Kung C, Ka S, Chung M, et al. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. J Ethnopharmacol. 2011;135:179-85 pubmed publisher
    ..To evaluate the protective effect of baicalein on myocardial dysfunction caused by endotoxaemia in rats and to explore the possible mechanisms...
  30. Chan E, Liu X, Guo D, Kwan Y, Leung G, Lee S, et al. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. Am J Chin Med. 2011;39:693-704 pubmed
    ..In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds...
  31. Pan T, Wang P, Leu Y, Wu T, Wu T. Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway. J Ethnopharmacol. 2012;139:829-37 pubmed publisher
    The bioactive components extracted from Scutellaria baicalensis Georgi (SB) have been widely used for anti-cancer, anti-oxidation, anti-inflammation and modulating the immune response.
  32. Wu J, Hu D, Wang K. [Study of Scutellaria baicalensis and Baicalin against antimicrobial susceptibility of Helicobacter pylori strains in vitro]. Zhong Yao Cai. 2008;31:707-10 pubmed
    To compare the antimicrobial activities of Scutellaria baicalensis and Baicalin against Helicobacter pylori (H. pylori) in vitro.
  33. Kumagai T, Muller C, Desmond J, Imai Y, Heber D, Koeffler H. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk Res. 2007;31:523-30 pubmed
    b>Scutellaria baicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S...
  34. Martin J, Dusek J. [The Baikal scullcap (Scutellaria baicalensis Georgi)--a potential source of new drugs]. Ceska Slov Farm. 2002;51:277-83 pubmed
    The scullcap (Scutellaria baicalensis Georgi) is a medicinal plant of traditional Chinese medicine and the drug--Scutellariae radix--is, because of its antioxidant, antiviral, antibacterial, antiinflammatory, antiallergic, and sedative ..
  35. Horvath C, Martos P, Saxena P. Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. J Chromatogr A. 2005;1062:199-207 pubmed
    ..array detection (DAD)-mass spectrometry (MS) in root and aerial tissues of the medicinal plant Scutellaria baicalensis was developed...
  36. Shao Z, Vanden Hoek T, Li C, Schumacker P, Becker L, Chan K, et al. Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro. Am J Chin Med. 2004;32:89-95 pubmed
    b>Scutellaria baicalensis (SbE) is a commonly used Chinese herb medicine and grape seed proanthocyanidins is a popular herbal supplement in the United States. Both herbs have been shown to possess potent antioxidant effects...
  37. Yu K, Gong Y, Lin Z, Cheng Y. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis. J Pharm Biomed Anal. 2007;43:540-8 pubmed
    Quantitative analysis and chromatographic fingerprinting for the quality evaluation of a Chinese herb Scutellaria baicalensis Georgi using capillary electrophoresis (CE) technique was developed. The separation was performed with a 50...
  38. Hwang Y, Jinhua M, Choi B, Cui C, Jeon W, Kim H, et al. Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments. J Ethnopharmacol. 2011;137:681-9 pubmed publisher
    Extracts of the roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used to relieve fever related to bacterial infection and inflammatory diseases in traditional Korean medicine and have been reported to be effective in ..
  39. Li H, Chen F. Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. J Chromatogr A. 2005;1074:107-10 pubmed
    The medicinal plant Scutellaria baicalensis Georgi has been used widely in traditional Chinese medicine for anti-inflammation, anticancer, antiviral and antibacterial infections, reducing the total cholesterol level and decreasing blood ..
  40. Guo X, Wang X, Su W, Zhang G, Zhou R. DNA barcodes for discriminating the medicinal plant Scutellaria baicalensis (Lamiaceae) and its adulterants. Biol Pharm Bull. 2011;34:1198-203 pubmed
    b>Scutellaria baicalensis GEORGI (Lamiaceae) is the botanical origin of the well-known traditional Chinese medicine "Huang Qin" (Radix Scutellariae)...
  41. Zandi K, Lim T, Rahim N, Shu M, Teoh B, Sam S, et al. Extract of Scutellaria baicalensis inhibits dengue virus replication. BMC Complement Altern Med. 2013;13:91 pubmed publisher
    b>Scutellaria baicalensis (S. baicalensis) is one of the traditional Chinese medicinal herbs that have been shown to possess many health benefits...
  42. Dong P, Zhang Y, Gu J, Wu W, Li M, Yang J, et al. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. J Ethnopharmacol. 2011;137:1373-80 pubmed publisher
    A traditional Chinese medicine Scutellaria baicalensis is prescribed for the treatment of a variety of inflammatory diseases and tumors in clinic in China...
  43. Su S, He C, Li L, Chen J, Zhou T. Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis. Chem Biodivers. 2008;5:1353-63 pubmed publisher
    b>Scutellaria baicalensis was collected from four wild and four cultivated populations from different locations in China...
  44. Waisundara V, Hsu A, Huang D, Tan B. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Chin Med. 2008;36:517-40 pubmed
    ..out to investigate the effect of combining the antidiabetic drug, metformin, with an ethanolic extract of Scutellaria baicalensis, a plant whose root is known for its radical scavenging activity...
  45. Takahashi H, Chen M, Pham H, Angst E, King J, Park J, et al. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011;1813:1465-74 pubmed publisher
    b>Scutellaria baicalensis (SB) and SB-derived polyphenols possess anti-proliferative activities in several cancers, including pancreatic cancer (PaCa). However, the precise molecular mechanisms have not been fully defined...
  46. Wu S, Sun A, Liu R. Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography. J Chromatogr A. 2005;1066:243-7 pubmed
    ..HSCCC) method for isolation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi (Huang-qin in Chinese) was successfully established by using ethyl acetate-methanol-1% acetic acid ..
  47. Heo H, Kim D, Choi S, Shin D, Lee C. Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. J Agric Food Chem. 2004;52:4128-32 pubmed
    The free radical scavenging activities of two major flavonoids (baicalein and baicalin) in Scutellaria baicalensis were determined...
  48. Yimam M, Zhao Y, Ma W, Jia Q, DO S, Shin J. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. Food Chem Toxicol. 2010;48:1202-9 pubmed publisher
    A standardized plant composition--UP446, with primarily baicalin from the roots of Scutellaria baicalensis and (+)-catechin from the heartwoods of Acacia catechu--has been used in both joint supplements and a prescription medical food...
  49. Xu H, Park N, Li X, Kim Y, Lee S, Park S. Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. Bioresour Technol. 2010;101:9715-22 pubmed publisher
    ..of genes in flavones biosynthesis was investigated in different organs and suspension cells obtained from Scutellaria baicalensis. Three full-length cDNAs encoding phenylalanine ammonia-lyase isoforms (SbPAL1, SbPAL2, and SbAPL3) and ..
  50. Lu T, Song J, Huang F, Deng Y, Xie L, Wang G, et al. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J Ethnopharmacol. 2007;110:412-8 pubmed
    ..quot;heat-clearing" multiherb remedy of traditional Chinese medicine, and Radix scutellariae (Scutellaria baicalensis Georgi, Labiatae) is a key ingredient herb in it...
  51. Yuan Y, Liu Y, Wu C, Chen S, Wang Z, Yang Z, et al. Water deficit affected flavonoid accumulation by regulating hormone metabolism in Scutellaria baicalensis Georgi roots. PLoS ONE. 2012;7:e42946 pubmed publisher
    The content of flavonoids especially baicalin and baicalein determined the medical quality of Scutellaria baicalensis which is a Chinese traditional medicinal plant...
  52. Hou Y, Lin S, Tsai S, Ko M, Chang Y, Chao P. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Planta Med. 2011;77:455-60 pubmed publisher
    Scutellariae Radix (root of Scutellaria baicalensis, SR) contains numerous flavonoids such as baicalin, baicalein, and wogonin...
  53. Kang B, Chung S, Kim S, Cho D, Kim T. Involvement of nuclear factor-kappaB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis. Planta Med. 2003;69:687-91 pubmed
    ..In this study we investigated the effects of baicalein, a flavonoid present in the root of Scutellaria baicalensis, on the production of IL-12 from mouse macrophages stimulated with lipopolysaccharide (LPS)...
  54. Regulska Ilow B, Biernat J, Grajeta H, Ilow R, Drzewicka M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Nahrung. 2004;48:123-8 pubmed
    ..The addition of bioflavonoids to the diet beneficially reduced the atherogenic index value in the group fed with fresh oil, and increased its value in the group fed with oxidized lard...
  55. Shin J, Kang H, Shim J, Sohn N. Scutellaria baicalensis attenuates blood-brain barrier disruption after intracerebral hemorrhage in rats. Am J Chin Med. 2012;40:85-96 pubmed
    ..The present study evaluated the effects of Scutellaria baicalensis (SR) water extracts on BBB disruption after intracerebral hemorrhage (ICH) in rats...
  56. Jang S, Kim H, Hwang K, Jekal S, Pae H, Choi B, et al. Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice. Immunopharmacol Immunotoxicol. 2003;25:585-94 pubmed
    ..These results show that the hepatoprotective effects of BA against AP overdose may be due to its ability to block the bioactivation of AP by inhibiting CYP2E1 expression...
  57. Ye F, Che Y, McMillen E, Gorski J, Brodman D, Saw D, et al. The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells. Nutr Cancer. 2009;61:530-7 pubmed publisher
    b>Scutellaria baicalensis is an anti-inflammatory and antineoplastic Chinese herbal therapy. We have previously shown that S. baicalensis can inhibit hepatocellular carcinoma (HCC) cell growth in vitro...
  58. Huang W, Lee A, Yang C. Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. Biosci Biotechnol Biochem. 2006;70:2371-80 pubmed
    The active ingredients of 'golden root' of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin...
  59. Yune T, Lee J, Cui C, Kim H, Oh T. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J Neurochem. 2009;110:1276-87 pubmed publisher
    ..In this study, we examined the neuroprotective effects of total ethanol extract of Scutellaria baicalensis (EESB), after SCI...
  60. Kim D, Hossain M, Kang Y, Jang J, Lee Y, Im E, et al. Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice. Int J Oncol. 2013;43:1652-8 pubmed publisher
    ..Baicalein (5,6,7-trihydroxyflavone) is a phenolic flavonoid compound derived mainly from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used in oriental medicine...
  61. Wang C, Calway T, Wen X, Smith J, Yu C, Wang Y, et al. Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Int J Oncol. 2013;42:1018-26 pubmed publisher
    b>Scutellaria baicalensis extract (SbE) has been shown to exert chemopreventive effects on several types of cancer...
  62. Himeji M, Ohtsuki T, Fukazawa H, Tanaka M, Yazaki S, Ui S, et al. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett. 2007;245:269-74 pubmed
    Methanol extract from cultured Scutellaria baicalensis cells inhibited the proliferation of human monocytic leukemia cell line THP-1 and human osteogenic sarcoma cell line HOS...
  63. Shang Y, Miao H, Cheng J, Qi J. Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats. Biol Pharm Bull. 2006;29:805-10 pubmed
    Previous studies reported that the total flavonoids from the stems and leaves of Scutellaria baicalensis Georgi (TFSS) could enhance and improve learning and memory abilities in experimental animals, and reduce the neuronal pathologic ..
  64. Li Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009;35:57-68 pubmed publisher
    ..b>Scutellaria baicalensis is one of the most popular and multi-purpose herb used in China traditionally for treatment of ..
  65. Lai M, Hsiu S, Hou Y, Tsai S, Chao P. Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis. Planta Med. 2004;70:132-7 pubmed
    Scutellariae Radix (SR), the root of Scutellaria baicalensis (Labiatae), is widely used in clinical Chinese medicine...
  66. Park H, Yoon S, Choi J, Lee G, Choi J, Shin C, et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. Eur J Pharmacol. 2007;574:112-9 pubmed
    In previous studies, we identified sedative effects of Scutellaria baicalensis extracts and found that these extracts or their constituents may also have anticonvulsive effects. Wogonin is a natural product isolated from S...
  67. Huang W, Chien P, Yang C, Lee A. Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. Chem Pharm Bull (Tokyo). 2003;51:339-40 pubmed
    ..Demethylation of 1 yielded 3, which, by oxidation with I(2)/dimethyl sulfoxide (DMSO), was readily converted to oroxylin A and wogonin after column chromatography...
  68. Burnett B, Jia Q, Zhao Y, Levy R. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food. 2007;10:442-51 pubmed
    A mixed extract containing two naturally occurring flavonoids, baicalin from Scutellaria baicalensis and catechin from Acacia catechu, was tested for cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibition via enzyme, cellular, and in ..
  69. Scheck A, Perry K, Hank N, Clark W. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. BMC Complement Altern Med. 2006;6:27 pubmed
    Flavonoid-rich extracts from the mature roots of Scutellaria baicalensis have been shown to exhibit antiproliferative effects on various cancer cell lines. We assessed the ability of an ethanolic extract of S...
  70. Zhang Y, Wang X, Wang X, Xu Z, Liu Z, Ni Q, et al. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. J Ethnopharmacol. 2006;108:355-60 pubmed
    The protective effect of flavonoids extracted from Scutellaria baicalensis Georgi on cerebral ischemia injury has been explored in experimental animals...
  71. Shang Y, Qin B, Cheng J, Miao H. Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells. Phytother Res. 2006;20:53-7 pubmed
    ..The neuroprotective effects of flavonoids from the stems and leaves of Scutellaria baicalensis Georgi (SSF) against hydrogen peroxide (H2O2)-induced rat pheochromocytoma line PC12 injury were ..
  72. Wang C, Li X, Wang Q, Mehendale S, Yuan C. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. Phytomedicine. 2010;17:63-8 pubmed publisher
    Based on our previous observation, the whole Scutellaria baicalensis extract (SbE) did not show significant breast cancer cell inhibitory effect...
  73. Kim D, Son E, Kim M, Heo Y, Nam J, Ro J, et al. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Planta Med. 2010;76:678-82 pubmed publisher
    ..Our results suggest that SHC reduce degranulation during mast cell activation and could be a promising candidate for the treatment of immune/allergic diseases related to mast cells...
  74. Gao J, Morgan W, Sanchez Medina A, Corcoran O. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicol Appl Pharmacol. 2011;254:221-8 pubmed publisher
    Despite a lack of scientific authentication, Scutellaria baicalensis is clinically used in Chinese medicine as a traditional adjuvant to chemotherapy of lung cancer...
  75. Sheng J, Chen H, Shen L. [Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis]. Guang Pu Xue Yu Guang Pu Fen Xi. 2009;29:211-3 pubmed
    b>Scutellaria baicalensis is one of the most important Chinese herbs. It is widely used in Asian medicine to improve impaired brain function and to treat headaches, and used to treat prostate cancer...
  76. Zhao Y, Li H, Gao Z, Gong Y, Xu H. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. Eur J Pharmacol. 2006;536:192-9 pubmed
    ..In this paper, the effects of the three active components of the root of Scutellaria baicalensis Georgi, i.e...
  77. Kimura Y, Sumiyoshi M. Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Phytomedicine. 2013;20:328-36 pubmed publisher
    ..We examined the effects of wogonin isolated from Scutellaria baicalensis roots on tumor growth and metastasis using a highly metastatic model in osteosarcoma LM8-bearing mice...
  78. Yuan Q, Zhang Z, Hu J, Guo L, Shao A, Huang L. Impacts of recent cultivation on genetic diversity pattern of a medicinal plant, Scutellaria baicalensis (Lamiaceae). BMC Genet. 2010;11:29 pubmed publisher
    ..b>Scutellaria baicalensis Georgi (Huang-qin or Chinese skullcap) is a very important medicinal plant in China...