salvia officinalis

Summary

Summary: A plant species of the Salvia genus known as a spice and medicinal plant.

Top Publications

  1. Miura K, Kikuzaki H, Nakatani N. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem. 2002;50:1845-51 pubmed
    A new abietane diterpenoid, 12-O-methyl carnosol (2), was isolated from the leaves of sage (Salvia officinalis L.), together with 11 abietane diterpenoids, 3 apianane terpenoids, 1 anthraquinone, and 8 flavonoids...
  2. Iuvone T, De Filippis D, Esposito G, D Amico A, Izzo A. The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity. J Pharmacol Exp Ther. 2006;317:1143-9 pubmed
    Traditional use and clinical reports suggest that the culinary herb sage (Salvia officinalis) may be effective for patients with mild to moderate Alzheimer's disease (AD)...
  3. Horiuchi K, Shiota S, Hatano T, Yoshida T, Kuroda T, Tsuchiya T. Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). Biol Pharm Bull. 2007;30:1147-9 pubmed
    An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid...
  4. Lima C, Valentao P, Andrade P, Seabra R, Fernandes Ferreira M, Pereira Wilson C. Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage. Chem Biol Interact. 2007;167:107-15 pubmed
    Common sage (Salvia officinalis L., Lamiaceae) is an aromatic and medicinal plant well known for its antioxidant properties. Some in vivo studies have shown the biological antioxidant effects of sage...
  5. Ben Farhat M, Jordan M, Chaouech Hamada R, Landoulsi A, Sotomayor J. Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L. J Agric Food Chem. 2009;57:10349-56 pubmed publisher
    The variation in the chemical composition of the essential oil of Salvia officinalis , growing in different habitats, was studied. GC-MS analysis revealed 57 compounds representing 94.68-96.80% of total oils...
  6. Eidi M, Eidi A, Bahar M. Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats. Nutrition. 2006;22:321-6 pubmed
    The leaves of sage (Salvia officinalis L., Lamiaceae) are reported to have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, astringent, eupeptic and anti-hydrotic effects...
  7. Bors W, Michel C, Stettmaier K, Lu Y, Foo L. Antioxidant mechanisms of polyphenolic caffeic acid oligomers, constituents of Salvia officinalis. Biol Res. 2004;37:301-11 pubmed
    ..acid, rosmarinic acid and oligomers of caffeic acid with multiple catechol groups are all constituents of Salvia officinalis. Their antioxidant potential was investigated with regard to their radical scavenging activity and the ..
  8. Keshavarz M, Mostafaie A, Mansouri K, Bidmeshkipour A, Motlagh H, Parvaneh S. In vitro and ex vivo antiangiogenic activity of Salvia officinalis. Phytother Res. 2010;24:1526-31 pubmed publisher
    ..Herein, the antiangiogenic activity of Salvia officinalis extract and its fractions was investigated. S...
  9. Hossain M, Rai D, Brunton N, Martin Diana A, Barry Ryan C. Characterization of phenolic composition in Lamiaceae spices by LC-ESI-MS/MS. J Agric Food Chem. 2010;58:10576-81 pubmed publisher
    ..The diagnostic fragmentation patterns of the compounds during collision-induced dissociation (CID) elucidated the structural information of the compounds analyzed...

More Information

Publications99

  1. Mayer B, Baggio C, Freitas C, dos Santos A, Twardowschy A, Horst H, et al. Gastroprotective constituents of Salvia officinalis L. Fitoterapia. 2009;80:421-6 pubmed publisher
    The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg...
  2. Horiuchi K, Shiota S, Kuroda T, Hatano T, Yoshida T, Tsuchiya T. Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. Biol Pharm Bull. 2007;30:287-90 pubmed
    We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE)...
  3. Jerkovic I, Mastelic J, Marijanović Z. A variety of volatile compounds as markers in unifloral honey from dalmatian sage (Salvia officinalis L.). Chem Biodivers. 2006;3:1307-16 pubmed
    Volatile compounds of unifloral Salvia officinalis L. honey has been investigated for the first time...
  4. Lima C, Fernandes Ferreira M, Pereira Wilson C. Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice. Food Chem Toxicol. 2007;45:456-64 pubmed
    In a previous study, the drinking of a Salvia officinalis tea (prepared as an infusion) for 14 days improved liver antioxidant status in mice and rats where, among other factors, an enhancement of glutathione-S-transferase (GST) activity ..
  5. Lima C, Azevedo M, Araujo R, Fernandes Ferreira M, Pereira Wilson C. Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?. Br J Nutr. 2006;96:326-33 pubmed
    Common sage (Salvia officinalis L.) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals...
  6. Sá C, Ramos A, Azevedo M, Lima C, Fernandes Ferreira M, Pereira Wilson C. Sage tea drinking improves lipid profile and antioxidant defences in humans. Int J Mol Sci. 2009;10:3937-50 pubmed publisher
    b>Salvia officinalis (common sage) is a plant with antidiabetic properties...
  7. Christensen K, Jørgensen M, Kotowska D, Petersen R, Kristiansen K, Christensen L. Activation of the nuclear receptor PPAR? by metabolites isolated from sage (Salvia officinalis L.). J Ethnopharmacol. 2010;132:127-33 pubmed publisher
    b>Salvia officinalis has been used as a traditional remedy against diabetes in many countries and its glucose-lowering effects have been demonstrated in animal studies...
  8. Lima C, Andrade P, Seabra R, Fernandes Ferreira M, Pereira Wilson C. The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol. 2005;97:383-9 pubmed
    ..the biosafety and bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L...
  9. Ninomiya K, Matsuda H, Shimoda H, Nishida N, Kasajima N, Yoshino T, et al. Carnosic acid, a new class of lipid absorption inhibitor from sage. Bioorg Med Chem Lett. 2004;14:1943-6 pubmed
    The methanolic extract from the leaves of Salvia officinalis L. (sage) showed significant inhibitory effect on serum triglyceride elevation in olive oil-loaded mice (500 and 1000 mg/kg, p.o...
  10. Raal A, Orav A, Arak E. Composition of the essential oil of Salvia officinalis L. from various European countries. Nat Prod Res. 2007;21:406-11 pubmed
    Variations in the essential oil composition of Salvia officinalis L. growing in Estonia and in other European countries were determined. The oils were obtained in yields of 2.2-24.8 mL kg(-1)...
  11. Kennedy D, Scholey A. The psychopharmacology of European herbs with cognition-enhancing properties. Curr Pharm Des. 2006;12:4613-23 pubmed
  12. Oboh G, Henle T. Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro. J Med Food. 2009;12:77-84 pubmed publisher
    ..sought to determine the antioxidant activity and protective ability of water-extractable phytochemicals from Salvia officinalis leaves (strongly aromatic leaves used in flavoring cooked foods) on lipid peroxidation induced by some pro-..
  13. Grausgruber Gröger S, Schmiderer C, Steinborn R, Novak J. Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae). J Plant Physiol. 2012;169:353-9 pubmed publisher
    Garden sage (Salvia officinalis L., Lamiaceae) is one of the most important medicinal and aromatic plants and possesses antioxidant, antimicrobial, spasmolytic, astringent, antihidrotic and specific sensorial properties...
  14. Radosavljevic I, Jakse J, Javornik B, Satovic Z, Liber Z. New microsatellite markers for Salvia officinalis (Lamiaceae) and cross-amplification in closely related species. Am J Bot. 2011;98:e316-8 pubmed publisher
    ..Microsatellite primers were identified to study the genetic diversity, population genetic structure, and relationships of common sage and closely related species...
  15. Vuković Gacić B, Nikcevic S, Beric Bjedov T, Knezevic Vukcevic J, Simic D. Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae. Food Chem Toxicol. 2006;44:1730-8 pubmed
    ..Limonene showed antimutagenic effect only in D7. Our data recommend sage monoterpenes for further chemoprevention studies...
  16. Hayouni E, Chraief I, Abedrabba M, Bouix M, Leveau J, Mohammed H, et al. Tunisian Salvia officinalis L. and Schinus molle L. essential oils: their chemical compositions and their preservative effects against Salmonella inoculated in minced beef meat. Int J Food Microbiol. 2008;125:242-51 pubmed publisher
    The essential oils (EOs) extracted from the aerial parts of cultivated Salvia officinalis L. and the berries of Schinus molle L...
  17. Slamenova D, Masterova I, Lábaj J, Horvathova E, Kubala P, Jakubikova J, et al. Cytotoxic and DNA-damaging effects of diterpenoid quinones from the roots of Salvia officinalis L. on colonic and hepatic human cells cultured in vitro. Basic Clin Pharmacol Toxicol. 2004;94:282-90 pubmed
    ..quinones (royleanone- SAR 3, horminone- SAR 26, and acetyl horminone- SAR 43) isolated from the roots of Salvia officinalis L...
  18. Aherne S, Kerry J, O Brien N. Effects of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells. Br J Nutr. 2007;97:321-8 pubmed
    ..The plant extracts examined were rosemary (Rosmarinus officinalis L.), oregano (Origanum vulgare L.), sage (Salvia officinalis L.) and echinacea (Echinacea purpurea L.)...
  19. Ehrnhöfer Ressler M, Fricke K, Pignitter M, Walker J, Walker J, Rychlik M, et al. Identification of 1,8-cineole, borneol, camphor, and thujone as anti-inflammatory compounds in a Salvia officinalis L. infusion using human gingival fibroblasts. J Agric Food Chem. 2013;61:3451-9 pubmed publisher
    Drinking or gargling Salvia officinalis L...
  20. Kontogianni V, Tomic G, Nikolic I, Nerantzaki A, Sayyad N, Stosic Grujicic S, et al. Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem. 2013;136:120-9 pubmed publisher
    The goal of this study was to monitor the anti-proliferative activity of Rosmarinus officinalis and Salvia officinalis extracts against cancer cells and to correlate this activity with their phytochemical profiles using liquid ..
  21. Zimmermann B, Walch S, Tinzoh L, Stühlinger W, Lachenmeier D. Rapid UHPLC determination of polyphenols in aqueous infusions of Salvia officinalis L. (sage tea). J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879:2459-64 pubmed publisher
    Sage tea, the aqueous infusion of dried sage leaves (Salvia officinalis L.), is used as a form of food as well as a form of traditional herbal medicine...
  22. Geneva M, Stancheva I, Boychinova M, Mincheva N, Yonova P. Effects of foliar fertilization and arbuscular mycorrhizal colonization on Salvia officinalis L. growth, antioxidant capacity, and essential oil composition. J Sci Food Agric. 2010;90:696-702 pubmed publisher
    ..and Glomus intraradices inoculation on the growth, qualitative and quantitative pattern of essential oil in Salvia officinalis was determined. Sage plants were grown in a glass house on a soil/sand mixture (w/w = 3:1)...
  23. Kennedy D, Pace S, Haskell C, Okello E, Milne A, Scholey A. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology. 2006;31:845-52 pubmed
    b>Salvia officinalis (sage) has previously been shown both to possess in vitro cholinesterase inhibiting properties, and to enhance mnemonic performance and improve mood in healthy young participants...
  24. Qnais E, Abu Dieyeh M, Abdulla F, Abdalla S. The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts. Pharm Biol. 2010;48:1149-56 pubmed publisher
    The leaf of sage Salvia officinalis L. (Lamiaceae) is reputed in the folk medicine of Arabia, and Jordan in particular, to relieve pain associated with gastrointestinal disturbance.
  25. Sokovic M, Glamoclija J, Marin P, Brkic D, Van Griensven L. Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model. Molecules. 2010;15:7532-46 pubmed publisher
    ..spicata, Ocimum basilicum, Origanum vulgare, Thymus vulgaris and Salvia officinalis have been determined. The antibacterial activity of these oils and their main components; i.e...
  26. Bozin B, Mimica Dukic N, Samojlik I, Jovin E. Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils. J Agric Food Chem. 2007;55:7879-85 pubmed
    The essential oils of rosemary ( Rosmarinus officinalis L.) and sage ( Salvia officinalis L.) were analyzed by means of gas chromatography-mass spectrometry and assayed for their antimicrobial and antioxidant activities...
  27. Schnitzler P, Nolkemper S, Stintzing F, Reichling J. Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations. Phytomedicine. 2008;15:62-70 pubmed
    Aqueous and ethanolic extracts of Salvia officinalis (Lamiaceae) from two different locations (Garden and Swabian Mountains) were examined in vitro on RC-37 cells for their antiviral activity against herpes simplex virus type 1 (HSV-1) ..
  28. Glisic S, Ristic M, Skala D. The combined extraction of sage (Salvia officinalis L.): ultrasound followed by supercritical CO2 extraction. Ultrason Sonochem. 2011;18:318-26 pubmed publisher
    A wide spectrum of phytochemicals could be isolated from sage (Salvia officinalis L...
  29. Radulescu V, Chiliment S, Oprea E. Capillary gas chromatography-mass spectrometry of volatile and semi-volatile compounds of Salvia officinalis. J Chromatogr A. 2004;1027:121-6 pubmed
    The essential oil and infusion of Salvia officinalis leaves have been widely applied in traditional medicine since ancient times and nowadays subjected to extensive research of their antibacterial, antiviral and cytotoxic properties...
  30. Rodrigues M, Kanazawa L, das Neves T, da Silva C, Horst H, Pizzolatti M, et al. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. J Ethnopharmacol. 2012;139:519-26 pubmed publisher
    b>Salvia officinalis L. has been used as a traditional herbal medicine for gastric disturbances and inflammatory processes...
  31. Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi A, Khani M. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther. 2003;28:53-9 pubmed
    ..b>Salvia officinalis has been used in herbal medicine for many centuries...
  32. Fischedick J, Standiford M, Johnson D, Johnson J. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. Bioorg Med Chem. 2013;21:2618-22 pubmed publisher
    ..In order to better understand the structure activity relationship of phenolic diterpenes from Salvia officinalis L...
  33. Russo A, Formisano C, Rigano D, Senatore F, Delfine S, Cardile V, et al. Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions. Food Chem Toxicol. 2013;55:42-7 pubmed publisher
    b>Salvia officinalis L. can be found worldwide and its leaves are commonly used as ingredient in food industry...
  34. Celik I, Isik I. Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats. Nat Prod Res. 2008;22:66-75 pubmed
    ..This study was designed to investigate the protective effects of Foeniculum vulgare (FV) and Salvia officinalis (SO) waters infusions against carcinogen chemical trichloroacetic acid (TCA)-exposure in rats...
  35. Alarcon Aguilar F, Roman Ramos R, Flores Saenz J, Aguirre Garcia F. Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. Phytother Res. 2002;16:383-6 pubmed
    The hypoglycaemic activities of four water ethanol extracts (WEE) prepared from Bidens pilosa L., Salvia officinalis L., Psacalium peltatum H.B.K. (Cass) and Turnera diffusa Willd. were investigated in healthy and alloxan-diabetic mice...
  36. Santos Gomes P, Seabra R, Andrade P, Fernandes Ferreira M. Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.). J Plant Physiol. 2003;160:1025-32 pubmed
    Sage (Salvia officinalis L.) calli were established by culturing internodal segments, excised from aseptic seedlings, on MS basal medium gellied with agar and supplemented with 0...
  37. Hubbert M, Sievers H, Lehnfeld R, Kehrl W. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. Eur J Med Res. 2006;11:20-6 pubmed
    ..II/III study with adaptive two-stage design and interim analysis compared the efficacy and tolerability of spray (containing a Salvia officinalis fluid extract) against placebo in the treatment of patients with acute viral pharyngitis. -
  38. Jedinak A, Muckova M, Kost álová D, Maliar T, Masterova I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch C. 2006;61:777-82 pubmed
    ..We found interesting results for beta-ursolic acid isolated from Salvia officinalis, which significantly inhibited all tested proteases in vitro in the micromolar range...
  39. Zivkovic J, Ristić M, Kschonsek J, Westphal A, Mihailović M, Filipović V, et al. Comparison of Chemical Profile and Antioxidant Capacity of Seeds and Oils from Salvia sclarea and Salvia officinalis. Chem Biodivers. 2017;: pubmed publisher
    ..Both seeds contained a large amount of oil (around 20%) rich in polyunsaturated fatty acids. While Salvia officinalis seed oil can be classified as oleic-linoleic oil, the predominant fatty acid in Salvia sclarea was ?-..
  40. Hasanein P, Felehgari Z, Emamjomeh A. Preventive effects of Salvia officinalis L. against learning and memory deficit induced by diabetes in rats: Possible hypoglycaemic and antioxidant mechanisms. Neurosci Lett. 2016;622:72-7 pubmed publisher
    Learning and memory impairment occurs in diabetes. Salvia officinalis L. (SO) has been used in Iranian traditional medicine as a remedy against diabetes. We hypothesized that chronic administration of SO (400, 600 and 800mg/kg, p.o...
  41. Rahte S, Evans R, Eugster P, Marcourt L, Wolfender J, Kortenkamp A, et al. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles. Planta Med. 2013;79:753-60 pubmed publisher
    ..In a recent clinical study, Salvia officinalis tincture was found to reduce hot flush frequency and intensity...
  42. Pellegrini M, Ricci A, Serio A, Chaves López C, Mazzarrino G, D Amato S, et al. Characterization of Essential Oils Obtained from Abruzzo Autochthonous Plants: Antioxidant and Antimicrobial Activities Assessment for Food Application. Foods. 2018;7: pubmed publisher
    ..The EOs were extracted from Rosmarinus officinalis, Origanum vulgare, Salvia officinalis, Mentha piperita, Allium sativum, Foeniculum vulgare, Satureja montana, ..
  43. Hamada Y, Stow D, Roberts D, Franklin J, Kyriakidis P. Assessing and monitoring semi-arid shrublands using object-based image analysis and multiple endmember spectral mixture analysis. Environ Monit Assess. 2013;185:3173-90 pubmed publisher
    ..The framework in this study can be applied to other physiognomically comparable shrubland communities. ..
  44. Kołodziejska J, Berner Strzelczyk A, Piechota Urbanska M. [Dry plant extracts in the prescription of dental hydrogels with Carbopol 971P]. Polim Med. 2009;39:27-35 pubmed
  45. Molnar M, Jerkovic I, Suknović D, Bilić Rajs B, Aladić K, Subarić D, et al. Screening of Six Medicinal Plant Extracts Obtained by Two Conventional Methods and Supercritical CO₂ Extraction Targeted on Coumarin Content, 2,2-Diphenyl-1-picrylhydrazyl Radical Scavenging Capacity and Total Phenols Content. Molecules. 2017;22: pubmed publisher
    ..Don, Angelica archangelica L., Lavandula officinalis L., Salvia officinalis L., Melilotus officinalis L., and Ruta graveolens L. were used...
  46. Kavvadias D, Monschein V, Sand P, Riederer P, Schreier P. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003;69:113-7 pubmed
    Benzodiazepine receptor binding assay-guided fractionation of the methanol extract from sage leaves ( Salvia officinalis L.) revealed three flavones and two abietane diterpenes functioning as benzodiazepine receptor-active components...
  47. Tedone L, Bonaccorsi I, Dugo P, Cotroneo A, Dugo G, Mondelloa L. Reliable identification and quantification of volatile components of sage essential oil using ultra HRGC. Nat Prod Commun. 2011;6:417-22 pubmed
    b>Salvia officinalis (common sage) essential oil was chemically characterized by means of GC-MS, using 100 meter capillary columns with two different stationary phases...
  48. Horst K, Rychlik M. Quantification of 1,8-cineole and of its metabolites in humans using stable isotope dilution assays. Mol Nutr Food Res. 2010;54:1515-29 pubmed publisher
    ..Summing up the urinary excretion over 10 h, 2-hydroxycineole, the 9-isomer, the 3-isomer and the 7-isomer accounted for 20.9, 17.2, 10.6 and 3.8% of the cineole dose, respectively. ..
  49. da Silva S, Ferreira D, Pintado M, Sarmento B. Chitosan-based nanoparticles for rosmarinic acid ocular delivery--In vitro tests. Int J Biol Macromol. 2016;84:112-20 pubmed publisher
    In this study, chitosan nanoparticles were used to encapsulate antioxidant rosmarinic acid, Salvia officinalis (sage) and Satureja montana (savory) extracts as rosmarinic acid natural vehicles...
  50. Stojanović Radić Z, Pejcic M, Stojanovic N, Sharifi Rad J, Stankovic N. Potential of Ocimum basilicum L. and Salvia officinalis L. essential oils against biofilms of P. aeruginosa clinical isolates. Cell Mol Biol (Noisy-le-grand). 2016;62:27-33 pubmed
    ..Ocimum basilicum L. (basil) and Salvia officinalis L. (sage) are widely used plants in traditional medicine for the treatment of different conditions...
  51. Barclay J, Vestey J, Lambert A, Balmer C. Reducing the symptoms of lymphoedema: is there a role for aromatherapy?. Eur J Oncol Nurs. 2006;10:140-9 pubmed
    ..It also slightly, but not significantly reduced limb volume. However, aromatherapy oils, carefully chosen on the basis that they should benefit this group, did not appear to influence any improvement in these measures...
  52. Abu Darwish M, Al Ramamneh E, Kyslychenko V, Karpiuk U. The antimicrobial activity of essential oils and extracts of some medicinal plants grown in Ash-shoubak region - South of Jordan. Pak J Pharm Sci. 2012;25:239-46 pubmed
    ..inhibitory effects of essential oils as well as chloroformic extracts of Thymus vulgaris, Thymus serpyllum, Salvia officinalis and Pimpinella anisum grown in Ash-shoubak region-south of Jordan and their possible individual ..
  53. Sertel S, Eichhorn T, Plinkert P, Efferth T. [Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)]. HNO. 2011;59:1203-8 pubmed publisher
    ..The aim of this investigation was to study the cytotoxicity of Salvia officinalis L. (sage) essential oil...
  54. Spiridonov N, Arkhipov V, Foigel A, Shipulina L, Fomkina M. Protonophoric and uncoupling activity of royleanones from Salvia officinalis and euvimals from Eucalyptus viminalis. Phytother Res. 2003;17:1228-30 pubmed
    The mechanism of action of quinones from the roots of Salvia officinalis L. (royleanones) and terpenoid phenolaldehydes from the leaves of Eucalyptus viminalis Labill. (euvimals) was studied...
  55. Grassi P, Novak J, Steinlesberger H, Franz C. A direct liquid, non-equilibrium solid-phase micro-extraction application for analysing chemical variation of single peltate trichomes on leaves of Salvia officinalis. Phytochem Anal. 2004;15:198-203 pubmed
    ..Three insertion levels of an individual plant of Salvia officinalis involving an immature apical young leaf, an expanding and a fully developed leaf, respectively, were used to ..
  56. Könczöl A, Muller J, Földes E, Béni Z, Végh K, Kery A, et al. Applicability of a blood-brain barrier specific artificial membrane permeability assay at the early stage of natural product-based CNS drug discovery. J Nat Prod. 2013;76:655-63 pubmed publisher
    ..of this procedure was demonstrated using extracts prepared from Tanacetum parthenium, Vinca major, Salvia officinalis, and Corydalis cava, representing different types of chemical diversity and complexity...
  57. Lachenmeier D, Uebelacker M. Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes?. Regul Toxicol Pharmacol. 2010;58:437-43 pubmed publisher
    ..In conclusion, the evidence does not point to any need for changes in regulations but confirms the current limits as sufficiently protective for consumers. ..
  58. da Silva S, Oliveira A, Ferreira D, Sarmento B, Pintado M. Development and validation method for simultaneous quantification of phenolic compounds in natural extracts and nanosystems. Phytochem Anal. 2013;24:638-44 pubmed publisher
  59. Chohan M, Naughton D, Jones L, Opara E. An investigation of the relationship between the anti-inflammatory activity, polyphenolic content, and antioxidant activities of cooked and in vitro digested culinary herbs. Oxid Med Cell Longev. 2012;2012:627843 pubmed publisher
    ..The significant correlations between TEAC and estimated phenolic content and the anti-inflammatory activity suggest a possible contributory role of polyphenols to the anti-inflammatory activity of the culinary herbs investigated. ..
  60. Santos Gomes P, Fernandes Ferreira M. Essential oils produced by in vitro shoots of sage (Salvia officinalis L.). J Agric Food Chem. 2003;51:2260-6 pubmed
    In vitro shoots of sage (Salvia officinalis L.) were established under eight different hormonal supplementations and proliferated by subculture of nodal shoot segments...
  61. Ignea C, Cvetkovic I, Loupassaki S, Kefalas P, Johnson C, Kampranis S, et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microb Cell Fact. 2011;10:4 pubmed publisher
    ..Using the developed molecular tools, new yeast strains were generated with increased capacity to produce plant terpenoids. The approach taken and the durability of the strains allow successive rounds of improvement to maximize yields. ..
  62. Flampouri E, Sotiropoulou Ν, Mavrikou S, Mouzaki Paxinou A, Tarantilis P, Kintzios S. Conductive polymer-based bioelectrochemical assembly for in vitro cytotoxicity evaluation: Renoprotective assessment of Salvia officinalis against carbon tetrachloride induced nephrotoxicity. Biochim Biophys Acta Gen Subj. 2017;1861:2304-2314 pubmed publisher
    ..The nephrotoxicity agent CCl4 and the medicinal plant Salvia officinalis were used on the proposed assembly. Renal cell viability was also assayed through the MTT assay...
  63. Tardugno R, Pellati F, Iseppi R, Bondi M, Bruzzesi G, Benvenuti S. Phytochemical composition and in vitro screening of the antimicrobial activity of essential oils on oral pathogenic bacteria. Nat Prod Res. 2018;32:544-551 pubmed publisher
    ..globulus, Eugenia caryophyllata, Leptospermum scoparium, Mentha arvensis, Mentha piperita, Myrtus communis, Salvia officinalis, Melaleuca alternifolia, Rosmarinus officinalis, Lavandula x intermedia, Thymus capitatus and Thymus ..
  64. Stege P, Sombra L, Messina G, Martinez L, Silva M. Determination of melatonin in wine and plant extracts by capillary electrochromatography with immobilized carboxylic multi-walled carbon nanotubes as stationary phase. Electrophoresis. 2010;31:2242-8 pubmed publisher
    ..The LOD for melatonin was 0.01 ng/mL. The method was successfully applied to the determination of melatonin in red and white wine, grape skin and plant extracts of Salvia officinalis L.
  65. Bouaziz M, Yangui T, Sayadi S, Dhouib A. Disinfectant properties of essential oils from Salvia officinalis L. cultivated in Tunisia. Food Chem Toxicol. 2009;47:2755-60 pubmed publisher
    The essential oils were obtained by hydro-distillation of the aerial part of Salvia officinalis L. cultivated in Sfax gardens, Tunisia...
  66. Exarchou V, Nenadis N, Tsimidou M, Gerothanassis I, Troganis A, Boskou D. Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. J Agric Food Chem. 2002;50:5294-9 pubmed
    ..This deshielding may be attributed to the strong intramolecular six-membered ring hydrogen bond of the OH(5)...CO(4) moiety. ..
  67. Binsi P, Nayak N, Sarkar P, Jeyakumari A, Muhamed Ashraf P, Ninan G, et al. Structural and oxidative stabilization of spray dried fish oil microencapsulates with gum arabic and sage polyphenols: Characterization and release kinetics. Food Chem. 2017;219:158-168 pubmed publisher
    ..The encapsulates containing sage extract showed a lower rate of lipid oxidation during storage. ..
  68. Vandecasteele K, Ost P, Oosterlinck W, Fonteyne V, Neve W, Meerleer G. Evaluation of the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation. Phytother Res. 2012;26:208-13 pubmed publisher
    The purpose of this pilot study was to evaluate the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation therapy (ADT)...
  69. Jaswir I, Che Man Y, Hassan T. Performance of phytochemical antioxidant systems in refined-bleached-deodorized palm olein during frying. Asia Pac J Clin Nutr. 2005;14:402-13 pubmed
    ..Samples of the oil after frying were analyzed for different physical and chemical properties. OR and OS were found to be effective phytochemical antioxidants protecting RBD palm olein against oxidative deterioration during frying. ..
  70. Belbahri L, Calmin G, Pawlowski J, Lefort F. Phylogenetic analysis and real time PCR detection of a presumbably undescribed Peronospora species on sweet basil and sage. Mycol Res. 2005;109:1276-87 pubmed
    ..In addition to this work, PCR primers for real time PCR analysis have been developed for the specific detection of this downy mildew pathogen from infected tissues or seeds. It is shown that these primers can also be used in classic PCR...
  71. Radwan A, Kleinwächter M, Selmar D. Impact of drought stress on specialised metabolism: Biosynthesis and the expression of monoterpene synthases in sage (Salvia officinalis). Phytochemistry. 2017;141:20-26 pubmed publisher
    ..Accordingly, the transcription rates of the monoterpene synthases were analyzed. Salvia officinalis plants were cultivated under moderate drought stress...
  72. Moss L, Rouse M, Wesnes K, Moss M. Differential effects of the aromas of Salvia species on memory and mood. Hum Psychopharmacol. 2010;25:388-96 pubmed publisher
    ..Research has demonstrated that orally administered Salvia officinalis and Salvia lavandulaefolia are capable of modulating cognition and mood...
  73. Ozan F, Polat Z, Tepe B, Er K. Influence of storage media containing Salvia officinalis on survival of periodontal ligament cells. J Contemp Dent Pract. 2008;9:17-24 pubmed
    The purpose of this study was to determine the ability of Salvia officinalis (S. officinalis) extracts to serve as a storage medium for the maintenance of periodontal ligament (PDL) cell viability of avulsed teeth...
  74. Karst J, Piculell B, Brigham C, Booth M, Hoeksema J. Fungal communities in soils along a vegetative ecotone. Mycologia. 2013;105:61-70 pubmed publisher
    ..High alpha and beta diversity and possible sampling artifacts necessitate extensive sampling to reveal differentiation in these fungal communities. ..
  75. Azevedo M, Lima C, Fernandes Ferreira M, Almeida M, Wilson J, Pereira Wilson C. Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose. Mol Nutr Food Res. 2011;55 Suppl 1:S15-25 pubmed publisher
    ..Additionally, SFT and RA for 4 days significantly inhibited the carbohydrate-induced adaptive increase of SGLT1 in BBM. SFT and RA modulate the trafficking of SGLT1 to the BBM and may contribute to the control of plasma glucose. ..
  76. Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd. 2001;8:373-82 pubmed
    ..The development of new antiviral drugs, especially herbal preparations, thus remains desirable. In a screening study with plant extracts, a rhubarb root extract and a sage extract showed a promising activity...
  77. Zhang L, Lin Y, Leng X, Huang M, Zhou G. Effect of sage (Salvia officinalis) on the oxidative stability of Chinese-style sausage during refrigerated storage. Meat Sci. 2013;95:145-50 pubmed publisher
    ..05). Addition of sage to the sausages at levels of 0.1% and 0.15% reduced textural deterioration during refrigerated storage (P<0.05). Sage used in this study had no negative effects on the sensory properties of sausages...
  78. Bandoniene D, Murkovic M, Venskutonis P. Determination of rosmarinic acid in sage and borage leaves by high-performance liquid chromatography with different detection methods. J Chromatogr Sci. 2005;43:372-6 pubmed
    ..The amount of rosmarinic acid in borage leaves is similar compared with Salvia officinalis (15 mg/g)...
  79. Baj T, Ludwiczuk A, Sieniawska E, Skalicka Wozniak K, Widelski J, Zieba K, et al. GC-MS analysis of essential oils from Salvia officinalis L.: comparison of extraction methods of the volatile components. Acta Pol Pharm. 2013;70:35-40 pubmed
    ..components composition in the samples obtained by hydrodistillation and solid-phase microextraction of Salvia officinalis was described...
  80. Calucci L, Pinzino C, Zandomeneghi M, Capocchi A, Ghiringhelli S, Saviozzi F, et al. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices. J Agric Food Chem. 2003;51:927-34 pubmed
    ..Significant losses of total ascorbate were found for black pepper, cinnamon, nutmeg, oregano, and sage, whereas a significant decrease of carotenoids content was observed for cinnamon, oregano, parsley, rosemary, bird pepper, and sage...
  81. Perry E, Howes M. Medicinal plants and dementia therapy: herbal hopes for brain aging?. CNS Neurosci Ther. 2011;17:683-98 pubmed publisher
  82. Tounekti T, Hernández I, Müller M, Khemira H, Munné Bosch S. Kinetin applications alleviate salt stress and improve the antioxidant composition of leaf extracts in Salvia officinalis. Plant Physiol Biochem. 2011;49:1165-76 pubmed publisher
    A pot experiment was carried out under glasshouse conditions with common sage (Salvia officinalis L...
  83. Hossain M, Brunton N, Martin Diana A, Barry Ryan C. Application of response surface methodology to optimize pressurized liquid extraction of antioxidant compounds from sage (Salvia officinalis L.), basil (Ocimum basilicum L.) and thyme (Thymus vulgaris L.). Food Funct. 2010;1:269-77 pubmed publisher
    ..05) higher than solid/liquid extracts. Predicted models were highly significant (p < 0.05) for both total phenol (TP) and FRAP values in all the spices with high regression coefficients (R(2)) ranging from 0.651 to 0.999...
  84. Estévez M, Ventanas S, Ramírez R, Cava R. Analysis of volatiles in porcine liver pâtés with added sage and rosemary essential oils by using SPME-GC-MS. J Agric Food Chem. 2004;52:5168-74 pubmed
  85. Modabbernia A, Akhondzadeh S. Saffron, passionflower, valerian and sage for mental health. Psychiatr Clin North Am. 2013;36:85-91 pubmed publisher
    ..This article discusses clinically relevant scientific information on medicinal extracts of 4 herbs: saffron, passionflower, valerian, and sage...
  86. Ozturk I, Tornuk F, Sagdic O, Kisi O. Application of non-linear models to predict inhibition effects of various plant hydrosols on Listeria monocytogenes inoculated on fresh-cut apples. Foodborne Pathog Dis. 2012;9:607-16 pubmed publisher
    ..monocytogenes counts. The ANN model was also effective; the MLR model was found to be poor at estimating L. monocytogenes numbers...
  87. Booth A, Amen R, Scott M, Greenway F. Oral dose-ranging developmental toxicity study of an herbal supplement (NT) and gallic acid in rats. Adv Ther. 2010;27:250-5 pubmed publisher
    ..To evaluate the combination of rhubarb, astragalus, red sage, ginger, and turmeric (mixture referred to as "NT") together with gallic acid for evidence of reproductive toxicity in rats...
  88. Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther. 2011;28:490-500 pubmed publisher
    ..Sage (Salvia officinalis) has been traditionally used to treat sweating and menopausal hot flushes, as well as to alleviate ..
  89. Zheljazkov V. Assessment of wool waste and hair waste as soil amendment and nutrient source. J Environ Qual. 2005;34:2310-7 pubmed
    ..Inka'), peppermint (Mentha x piperita L. 'Black Mitchum'), and garden sage (Salvia officinalis L...
  90. Feres M, Figueiredo L, Barreto I, Coelho M, Araujo M, Cortelli S. In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. J Int Acad Periodontol. 2005;7:90-6 pubmed