salvia miltiorrhiza

Summary

Summary: A plant species which is known as an Oriental traditional medicinal plant.

Top Publications

  1. Yang Y, Hou S, Cui G, Chen S, Wei J, Huang L. Characterization of reference genes for quantitative real-time PCR analysis in various tissues of Salvia miltiorrhiza. Mol Biol Rep. 2010;37:507-13 pubmed publisher
    Five reference genes, 18S, EF1alpha, alpha-Tubulin, Ubiquitin and Actin, from Salvia miltiorrhiza were analyzed as internal controls for gene expression profiling assay using quantitative real-time polymerase chain reaction (qRT-PCR)...
  2. Song Z, Li X, Wang H, Wang J. Genetic diversity and population structure of Salvia miltiorrhiza Bge in China revealed by ISSR and SRAP. Genetica. 2010;138:241-9 pubmed publisher
    b>Salvia miltiorrhiza Bge is a traditional Chinese medicinal herb used as an important drug to cure cardiovascular diseases...
  3. Hou X, Shao F, Ma Y, Lu S. The phenylalanine ammonia-lyase gene family in Salvia miltiorrhiza: genome-wide characterization, molecular cloning and expression analysis. Mol Biol Rep. 2013;40:4301-10 pubmed publisher
    b>Salvia miltiorrhiza Bunge is a well-known material of traditional Chinese medicine. Hydrophilic phenolic acids, such as rosmarinic acid and salvianolic acid B, are a group of pharmaceutically important compounds in S. miltiorrhiza...
  4. Chen Y, Jinn T, Chung T, Li F, Fan R, Tzen J. Magnesium lithospermate B extracted from Salvia miltiorrhiza elevates intracellular Ca(2+) level in SH-SY5Y cells. Acta Pharmacol Sin. 2010;31:923-9 pubmed publisher
    ..The elevated Ca(2+) levels seem to be supplied by Ca(2+) influx through the reversed mode of the Na(+)/Ca(2+) exchanger and intracellular release from endoplasmic reticulum. ..
  5. Zhou R, He L, Li Y, Shen Y, Chao R, Du J. Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction. J Ethnopharmacol. 2012;139:440-6 pubmed publisher
    b>Salvia miltiorrhiza has long been used in the traditional Chinese formulations for the treatment of heart ischemic diseases...
  6. Zhang J, Zhang Y, Zhang Y, Gao Y, Ma J, Wang N, et al. Salvia miltiorrhiza (Danshen) injection ameliorates iron overload-induced cardiac damage in mice. Planta Med. 2013;79:744-52 pubmed publisher
    The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), first recorded in the "Shen Nong's Herbal Classic", has long been used to treat cardiovascular conditions, although the mechanism(s) underlying its effects ..
  7. Li C, Dong X, Fan X, Wu J, Wang Q, Tian X, et al. Aqueous extract of danshen (Salvia miltiorrhiza Bunge) protects ovariectomized rats fed with high-fat diet from endothelial dysfunction. Menopause. 2013;20:100-9 pubmed publisher
    ..Danshen, the dried root of Salvia miltiorrhiza Bunge, has been used clinically in China to treat CVD and dyslipidemia in postmenopausal women, and its ..
  8. Lee W, Cheung C, Liu K, Fung K, Wong J, Lai P, et al. Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells. J Nat Prod. 2010;73:854-9 pubmed publisher
    ..1), dihydrotanshinone (2), tanshinone I (3), and tanshinone IIA (4), the active lipophilic constituents of Salvia miltiorrhiza, using MTT and caspase-3 activity assays and poly(ADP-ribose) polymerase cleavage in HepG2, Hep3B, and PLC/..
  9. Jiang M, Wang C, Zhang Y, Feng Y, Wang Y, Zhu Y. Sparse partial-least-squares discriminant analysis for different geographical origins of Salvia miltiorrhiza by (1) H-NMR-based metabolomics. Phytochem Anal. 2014;25:50-8 pubmed publisher
    ..To establish a method for detecting both primary and secondary metabolites in Salvia miltiorrhiza and screening potential geographical biomarkers effectively. Primary and secondary metabolites of S...

More Information

Publications86

  1. Slusarczyk S, Zimmermann S, Kaiser M, Matkowski A, Hamburger M, Adams M. Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza. Planta Med. 2011;77:1594-6 pubmed publisher
    ..throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum...
  2. Ahn Y, Kim S, Lee S, Ahn S, Kang S, Chung J, et al. Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease. Phytother Res. 2010;24:1886-92 pubmed publisher
    ..This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy...
  3. Lee S, Jeong S, Yang H, Jeong S, Jang Y, Park C, et al. Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages. J Ethnopharmacol. 2012;139:541-8 pubmed publisher
    Danshen (Salvia miltiorrhiza) is widely used in traditional herbal medicines for relief of a variety of symptoms related to complications arising from vascular diseases such as hypertension, diabetes, and atherosclerosis...
  4. Cheung D, Koon C, Wat E, Ko C, Chan J, Yew D, et al. A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor ?B (NF?B) pathway. J Ethnopharmacol. 2013;145:776-83 pubmed publisher
    The herbal formula DG, containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen), has long history in treating cardiovascular diseases...
  5. Wei X, Liu Y, Li Q, Yan L, Hu B, Pan C, et al. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation. 2013;20:17-29 pubmed publisher
    ..All the alterations after I/R were significantly ameliorated by CP. Post-treatment with CP ameliorates I/R-induced myocardial fibrosis, suggesting that CP may be applied as an option for preventing cardiac remodeling after I/R injury. ..
  6. Ng C, Koon C, Cheung D, Lam M, Leung P, Lau C, et al. The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation. J Ethnopharmacol. 2011;137:1366-72 pubmed publisher
    ..Radix Salviae miltiorrhizae (Danshen) and Radix Puerariae lobatae (Gegen) have long been used in traditional Chinese Medicine and serve as the principal herbs in treating cardiovascular disease...
  7. Xiao Y, Zhang L, Gao S, Saechao S, Di P, Chen J, et al. The c4h, tat, hppr and hppd genes prompted engineering of rosmarinic acid biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. PLoS ONE. 2011;6:e29713 pubmed publisher
    ..acid (RA) biosynthesis pathway for the production of beneficial RA and lithospermic acid B (LAB) in Salvia miltiorrhiza hairy root cultures...
  8. Chiu P, Wong S, Leung H, Leong P, Chen N, Zhou L, et al. Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKC?/mK(ATP) pathway in rats. Phytomedicine. 2011;18:916-25 pubmed publisher
    Danshen-Gegen (DG) decoction, an herbal formulation comprising Radix Salvia Miltiorrhiza and Radix Puerariae Lobatae, is prescribed for the treatment of coronary heart disease in Chinese medicine...
  9. Joe Y, Zheng M, Kim H, Kim S, Uddin M, Park C, et al. Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities. J Pharmacol Exp Ther. 2012;341:850-8 pubmed publisher
    b>Salvia miltiorrhiza (Danshen), a traditional Chinese herbal medicine, is commonly used for the prevention and treatment of cardiovascular disorders including atherosclerosis...
  10. Zhao Y, Hao Y, Ji H, Fang Y, Guo Y, Sha W, et al. Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. Cancer Prev Res (Phila). 2010;3:787-96 pubmed publisher
    ..We found that salvianolic acid B (Sal-B), isolated from Salvia miltiorrhiza Bge, can effectively suppress COX-2 expression and induce apoptosis in a variety of cancer cell lines...
  11. Paik Y, Yoon Y, Lee H, Jung M, Kang S, Chung S, et al. Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats. Exp Mol Med. 2011;43:341-9 pubmed
    ..We concluded that MLB has potent antifibrotic effect in TAA-treated cirrhotic rats, and inhibits fibrogenic responses in HSCs. These data suggest that MLB has potential as a novel therapy for hepatic fibrosis. ..
  12. Yang D, Ma P, Liang X, Wei Z, Liang Z, Liu Y, et al. PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots. Physiol Plant. 2012;146:173-83 pubmed publisher
    Tanshinones, a group of active ingredients in Salvia miltiorrhiza, are derived from at least two biosynthetic pathways, which are the mevalonate (MVA) pathway in the cytosol and the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway in ..
  13. Fan G, Zhu Y, Guo H, Wang X, Wang H, Gao X. Direct vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization. J Cardiovasc Pharmacol. 2011;57:340-7 pubmed publisher
    b>Salvia miltiorrhiza (Danshen) has been widely used in China and other Asian countries for treating various cardiovascular diseases resulting from its ability to improve coronary microcirculation and increase coronary blood flow...
  14. Koon C, Woo K, Leung P, Fung K. Salviae Miltiorrhizae Radix and Puerariae Lobatae Radix herbal formula mediates anti-atherosclerosis by modulating key atherogenic events both in vascular smooth muscle cells and endothelial cells. J Ethnopharmacol. 2011;138:175-83 pubmed publisher
    ..Salviae Miltiorrhizae Radix (Danshen) and Puerariae Lobatae Radix (Gegen) are principal herbs have long been used in combination for treating cardiovascular disease...
  15. Ren Z, Tong Y, Xu W, Ma J, Chen Y. Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression. Phytomedicine. 2010;17:212-8 pubmed publisher
    The root of Salvia miltiorrhiza Bunge, a well-known traditional Chinese medicine, has been used effectively for the treatment of cardiovascular diseases for a long time...
  16. Qiao Z, Ma J, Liu H. Evaluation of the antioxidant potential of Salvia miltiorrhiza ethanol extract in a rat model of ischemia-reperfusion injury. Molecules. 2011;16:10002-12 pubmed publisher
    The present study was undertaken to evaluate the protection potential of ethanol extract of Salvia miltiorrhiza (SMEE) against oxidative injury in the ischemia-reperfusion (I/R) model of rats in vivo...
  17. Li M, Zhang L, Cai R, Gao Y, Qi Y. Lipid-soluble extracts from Salvia miltiorrhiza inhibit production of LPS-induced inflammatory mediators via NF-?B modulation in RAW 264.7 cells and perform antiinflammatory effects in vivo. Phytother Res. 2012;26:1195-204 pubmed publisher
    b>Salvia miltiorrhiza, a traditional Chinese herbal medicine, is used to treat various inflammatory diseases. In the present study, the antiinflammatory effects of S...
  18. Wing Shing Cheung D, Koon C, Ng C, Leung P, Fung K, Kar Sing Poon S, et al. The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: a study of the combination effects of the 2-herb formula. J Ethnopharmacol. 2012;143:859-66 pubmed publisher
    The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) are principle herbs of Chinese herbal formulae which have long been used to treat cardiovascular diseases.
  19. Wang J, Wu J. Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures. Appl Microbiol Biotechnol. 2010;88:437-49 pubmed publisher
    b>Salvia miltiorrhiza Bunge (Lamiaceae) root, generally called Danshen, is an important herb in Chinese medicine widely used for treatment of cardiovascular diseases...
  20. Zhang Y, Li X, Wang Z. Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents. Food Chem Toxicol. 2010;48:2656-62 pubmed publisher
    Leaf of Salvia miltiorrhiza Bunge, the waste part during the root harvest, is rich in health-promoting phenolics and is a novel resource of natural antioxidants. The acetone and methanol extracts of leaves (AL and ML, respectively) of S...
  21. Cui Y, Bhandary B, Marahatta A, Lee G, Li B, Kim D, et al. Characterization of Salvia miltiorrhiza ethanol extract as an anti-osteoporotic agent. BMC Complement Altern Med. 2011;11:120 pubmed publisher
    b>Salvia miltiorrhiza (SM) has long been used as a traditional oriental medicine for cardiovascular disease. Accumulating evidence also indicates that SM has anti-osteoporotic effects...
  22. Cui B, Liang Z, Liu Y, Liu F, Zhu J. [Effects of ABA and its biosynthetic inhibitor fluridone on accumulation of penolic acids and activity of PAL and TAT in hairy root of Salvia miltiorrhiza]. Zhongguo Zhong Yao Za Zhi. 2012;37:754-9 pubmed
    ..Conducted 4 different concentrations in the hairy root of Salvia miltiorrhiza after culturing 18 days and treated with fluridone...
  23. Shu Z, Wang Z, Mu X, Liang Z, Guo H. A dominant gene for male sterility in Salvia miltiorrhiza Bunge. PLoS ONE. 2012;7:e50903 pubmed publisher
    A natural male sterile mutant of Salvia miltiorrhiza (Labiatae, Sh-B) was found during field survey in 2002...
  24. Wang Y, Xu F, Chen J, Shen X, Deng Y, Xu L, et al. Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: inhibition by salvianolic acid B from Salvia miltiorrhiza. Phytomedicine. 2011;19:13-9 pubmed publisher
    ..In conclusion, our results provide evidence for a direct influence of MMP-9 on cardiac fibroblast migration, collagen and cytokine secretion, which can be attenuated by SalB...
  25. Liu J, Lee T, Miedzyblocki M, Chan G, Bigam D, Cheung P. Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets. J Ethnopharmacol. 2011;137:44-9 pubmed publisher
    Tanshinone IIA (STS), an active ingredient of the Chinese herb Danshen (Salvia miltiorrhiza) for angina and stroke in adults, has been reported to inhibit platelet function...
  26. Song J, Wang Z. RNAi-mediated suppression of the phenylalanine ammonia-lyase gene in Salvia miltiorrhiza causes abnormal phenotypes and a reduction in rosmarinic acid biosynthesis. J Plant Res. 2011;124:183-92 pubmed publisher
    Medicinal Salvia miltiorrhiza contains two main groups of active pharmaceutical ingredients: lipid-soluble tanshinones and water-soluble phenolic acids, including rosmarinic acid and salvianolic acid B...
  27. Dai H, Xiao C, Liu H, Tang H. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion. J Proteome Res. 2010;9:1460-75 pubmed publisher
    ..To understand the comprehensive metabolic responses of Salvia miltiorrhiza Bunge (SMB) to continuous and exhaustive water depletion, we characterized the SMB metabonomic variations ..
  28. Liang Z, Yang D, Liang X, Zhang Y, Liu Y, Liu F. Roles of reactive oxygen species in methyl jasmonate and nitric oxide-induced tanshinone production in Salvia miltiorrhiza hairy roots. Plant Cell Rep. 2012;31:873-83 pubmed publisher
    b>Salvia miltiorrhiza is one of the most popular traditional Chinese medicinal plants for treatment of coronary heart disease. Tanshinones are the main biological active compounds in S. miltiorrhiza...
  29. Kai G, Xu H, Zhou C, Liao P, Xiao J, Luo X, et al. Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. Metab Eng. 2011;13:319-27 pubmed publisher
    ..synthase (DXS) and geranylgeranyl diphosphate synthase (GGPPS) involved in tanshinone biosynthesis into Salvia miltiorrhiza hairy roots by Agrobacterium-mediated gene transfer technology...
  30. Sun X, Fu X, Cai H, Liu Q, Li C, Liu Y, et al. Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice. Phytother Res. 2011;25:1087-94 pubmed publisher
    This study was designed to investigate mechanisms of the protective effects of Salvia miltiorrhiza polysaccharide (SMPS) against lipopolysaccharide (LPS)-induced immunological liver injury (ILI) in Bacille Calmette-Guérin (BCG)-primed ..
  31. Yang T, Lin F, Chen Y, Chiu J, Shiao M, Tsai C, et al. Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits. J Sci Food Agric. 2011;91:134-41 pubmed publisher
    ..In this study the in vitro and in vivo inhibitory effects of Sal B on oxidative stress were determined...
  32. Qian J, Song J, Gao H, Zhu Y, Xu J, Pang X, et al. The complete chloroplast genome sequence of the medicinal plant Salvia miltiorrhiza. PLoS ONE. 2013;8:e57607 pubmed publisher
    b>Salvia miltiorrhiza is an important medicinal plant with great economic and medicinal value. The complete chloroplast (cp) genome sequence of Salvia miltiorrhiza, the first sequenced member of the Lamiaceae family, is reported here...
  33. Guo Y, Zhou L, Li T, Wang L. Preparative separation of lithospermic acid B from Salvia miltiorrhiza by polyamide resin and preparative high-performance liquid chromatography. J Chromatogr A. 2011;1218:4606-11 pubmed publisher
    ..separating lithospermic acid B (LAB) from a crude extract of the roots of the traditional Chinese medicine Salvia miltiorrhiza Bunge ("Danshen")...
  34. Gong Y, Li Y, Lu Y, Li L, Abdolmaleky H, Blackburn G, et al. Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int J Cancer. 2011;129:1042-52 pubmed publisher
    ..The objective of this study was to determine the effects of a group of tanshinones from a Chinese herb Salvia Miltiorrhiza, cryptotanshinone (CT), tanshinone IIA (T2A) and tanshinone I (T1) on prostate cancer...
  35. Yan Y, Wang Z, Tian W, Dong Z, Spencer D. Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza. Sci China Life Sci. 2010;53:273-85 pubmed publisher
    b>Salvia miltiorrhiza Bge. is a well-known traditional Chinese herb. Its roots have been formulated and used clinically for the treatment of various diseases...
  36. Ming Q, Han T, Li W, Zhang Q, Zhang H, Zheng C, et al. Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza. Phytomedicine. 2012;19:330-3 pubmed publisher
    In this study the isolation of an endophytic fungus from the root of the medicinal herb Salvia miltiorrhiza Bunge is reported for the first time...
  37. Zhang Y, Zhang Y, Xie Y, Gao Y, Ma J, Yuan J, et al. Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza. J Ethnopharmacol. 2013;148:671-81 pubmed publisher
    b>Salvia miltiorrhiza (SM, also known as Danshen) is a well-known Chinese medicinal herb, which has shown hepatoprotective effects with anti-fibrotic, anti-oxidative, anti-inflammatory and anti-apoptotic properties...
  38. Zhou X, Chan K, Yeung J. Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes. Drug Metabol Drug Interact. 2012;27:9-18 pubmed publisher
    Danshen, the dried root and rhizome of Salvia miltiorrhiza Bunge, is a widely used medicinal plant for the treatment of cardiovascular diseases in China and a complementary medicine in the West...
  39. Liu X, Yang Y, Zhang X, Xu S, He S, Huang W, et al. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2 cell. J Gastroenterol Hepatol. 2010;25:420-6 pubmed publisher
    Compound Astragalus and Salvia miltiorrhiza extract (CASE) is made up of astragalosides, astragalus polysaccharide and salvianolic acids extracted from Astragalus membranaceus Bunge (Leguminosae) and Salvia miltiorhiza Bunge (Lamiaceae) ..
  40. Gu X, Chen J, Xiao Y, Di P, Xuan H, Zhou X, et al. Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza. Plant Cell Rep. 2012;31:2247-59 pubmed publisher
    ..3.99.6). Here, we cloned and characterized the AOC gene (SmAOC) from Salvia miltiorrhiza. As expected, SmAOC expression was induced by abiotic stimuli such as methyl jasmonate (MeJA), ultraviolet ..
  41. He S, Yang Y, Liu X, Huang W, Yang S, Zhang X. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-??/?Smad pathway. Br J Dermatol. 2012;166:564-74 pubmed publisher
    ..We have previously demonstrated that compound Astragalus and Salvia miltiorrhiza extract (CASE) inhibits liver fibrosis and reduces invasion capacity of HepG2 cells by mediating the TGF-?/..
  42. Dai H, Xiao C, Liu H, Hao F, Tang H. Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Miltiorrhiza Bunge. J Proteome Res. 2010;9:1565-78 pubmed publisher
    ..Here, we systematically characterized the metabonomic variations associated with three Salvia miltiorrhiza Bunge (SMB) cultivars using the combined NMR and LC-DAD-MS detections in conjunction with multivariate data ..
  43. Tang Y, Wang M, Le X, Meng J, Huang L, Yu P, et al. Antioxidant and cardioprotective effects of Danshensu (3-(3, 4-dihydroxyphenyl)-2-hydroxy-propanoic acid from Salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats. Phytomedicine. 2011;18:1024-30 pubmed publisher
    ..These data demonstrate that DSS can prevent cardiac I/R injury and improve cardiac function in a rat model of hypertrophy, the effects partially resulting from antioxidants and the protection from Cx43 expression...
  44. Liang X, Chen X, Liang Q, Zhang H, Hu P, Wang Y, et al. Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats. J Proteome Res. 2011;10:790-9 pubmed publisher
    ..The Panax ginseng group, Salvia miltiorrhiza group, and SLF group were treated with water extractions of Panax ginseng (PG), Salvia miltiorrhiza (SM), ..
  45. Zhang S, Liu Y, Shen S, Liang Z, Yang D. [Effects of elicitors on accumulation of phenolic acids and tanshinones in Salvia miltiorrhiza hairy root]. Zhongguo Zhong Yao Za Zhi. 2011;36:1269-74 pubmed
    ..methyl jasmonate and their synergistic action on the accumulation of phenolic acids and tanshinones in Salvia miltiorrhiza hairy root. Different elicitors were added to S...
  46. Dong J, Wan G, Liang Z. Accumulation of salicylic acid-induced phenolic compounds and raised activities of secondary metabolic and antioxidative enzymes in Salvia miltiorrhiza cell culture. J Biotechnol. 2010;148:99-104 pubmed publisher
    ..on the accumulation of phenolic compounds and the activities of PAL, TAT, SOD, CAT and POD enzymes in the Salvia miltiorrhiza cell culture...
  47. Tang C, Xue H, Bai C, Fu R. Regulation of adhesion molecules expression in TNF-?-stimulated brain microvascular endothelial cells by tanshinone IIA: involvement of NF-?B and ROS generation. Phytother Res. 2011;25:376-80 pubmed publisher
    ..The present study explored the effects of tanshinone IIA (Tan IIA), an active ingredient present in the Salvia miltiorrhiza root, on the expression of cellular adhesion molecules in TNF-?-stimulated brain microvascular endothelial ..
  48. Trinh H, Chae S, Joh E, Son K, Jeon S, Kim D. Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2010;132:344-8 pubmed publisher
    The rhizome of Salvia miltiorrhiza Bunge (SM, family Labiatae), which contains tanshinones as main constituents, has been used as a cardiovascular and anti-inflammatory agent in Chinese medicine.
  49. Cui G, Huang L, Tang X, Zhao J. Candidate genes involved in tanshinone biosynthesis in hairy roots of Salvia miltiorrhiza revealed by cDNA microarray. Mol Biol Rep. 2011;38:2471-8 pubmed publisher
    b>Salvia miltiorrhiza is a valuable Chinese herb (Danshen) that is widely used in traditional Chinese medicine. Diterpene quinones, known as tanshinones, are the main bioactive components of S...
  50. Zou C, Lu F, Mao W, Liu X. Chinese herbal medicine Danshen formulations for preventing renal disease in Henoch-Schönlein Purpura: a systematic review and meta-analysis. J Altern Complement Med. 2012;18:394-401 pubmed publisher
    ..The study objective was to evaluate the use of Danshen formulations in preventing renal disease in Henoch-Schönlein Purpura (HSP) either as sole agents or in combination with other drug regimens...
  51. Lee S, Kim Y, Lee S, Lee B. The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy. J Ethnopharmacol. 2011;137:1409-14 pubmed publisher
    Diabetic nephropathy (DN) is the most common cause of end stage renal disease. In this study, the effects of Salvia miltiorrhiza (SM) were studied in an experimental rat model of DN that was induced by streptozotocin (STZ) treatment.
  52. Wu W, Wang Y. Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components. Acta Pharmacol Sin. 2012;33:1119-30 pubmed publisher
    b>Salvia miltiorrhiza, a traditional medical herb known as danshen, has been widely used in China to improve blood circulation, relieve blood stasis, and treat coronary heart disease...
  53. Yan Q, Wu J, Liu R. Modeling of tanshinone synthesis and phase distribution under the combined effect of elicitation and in situ adsorption in Salvia miltiorrhiza hairy root cultures. Biotechnol Lett. 2011;33:813-9 pubmed publisher
    ..In conclusion, the modeling of tanshinone synthesis and phase distribution identified the process mechanism under the combined effect of elicitation and adsorption and this modeling can be used in similar plant tissue culture systems...
  54. Wu S, Wu D, Liang J, Berthod A. Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge. J Sep Sci. 2012;35:964-76 pubmed publisher
    ..The model is tested with the separation of tanshinones from the rhizome of Salvia miltiorrhiza Bunge...
  55. Zhang Y, Won S, Jiang C, Lee H, Jeong S, Lee E, et al. Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012;29:1595-608 pubmed publisher
    ..To test whether tanshinones inhibit prostate cancer (PCa) growth at least in part through inhibiting androgen receptor (AR) signaling...
  56. Cui G, Feng H, Li W, Wang W, Huang L. [Cloning and polymorphism analysis of SmERF in Salvia miltiorrhiza]. Yao Xue Xue Bao. 2010;45:1188-93 pubmed
    ..An ERF gene from Salvia miltiorrhiza is cloned and divided into ERF gene family group VII of Arabidopsis and Rice...
  57. Shao F, Lu S. Genome-wide identification, molecular cloning, expression profiling and posttranscriptional regulation analysis of the Argonaute gene family in Salvia miltiorrhiza, an emerging model medicinal plant. BMC Genomics. 2013;14:512 pubmed publisher
    ..The AGO gene family has been analyzed in various plant species; however, there is no report about AGOs in the well-known Traditional Chinese Medicine (TCM) plant, Salvia miltiorrhiza.
  58. Wu K, Zhang Q, Liu Q, Tang F, Long Y, Yao S. Ionic liquid surfactant-mediated ultrasonic-assisted extraction coupled to HPLC: application to analysis of tanshinones in Salvia miltiorrhiza bunge. J Sep Sci. 2009;32:4220-6 pubmed publisher
    ..As an example, this method was applied to determine tanshinones in Chinese herbal medicine Salvia miltiorrhiza bunge...
  59. Han B, Zhang X, Zhang Q, Zhao G, Wei J, Ma S, et al. Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion. Arch Cardiovasc Dis. 2011;104:313-24 pubmed publisher
    ..Microvascular reflow is crucial for myocyte survival during ischaemia/reperfusion injury...
  60. Wang D, Yao W, Song Y, Liu W, Wang Z. Molecular characterization and expression of three galactinol synthase genes that confer stress tolerance in Salvia miltiorrhiza. J Plant Physiol. 2012;169:1838-48 pubmed publisher
    ..We cloned and characterized three Gols genes in Salvia miltiorrhiza. Their expression followed three distinct patterns...
  61. Jia X, Li H, Luo J, Lu Q, Peng Y, Shi L, et al. Rational design of core-shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge. Anal Bioanal Chem. 2012;403:2691-703 pubmed publisher
    ..CS-MIP) for use in the highly selective separation of Tanshinone IIA (TSIIA) from the crude extracts of Salvia miltiorrhiza Bunge (SMB)...
  62. Ma Y, Yuan L, Wu B, Li X, Chen S, Lu S. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. J Exp Bot. 2012;63:2809-23 pubmed publisher
    Terpenoids are the largest class of plant secondary metabolites and have attracted widespread interest. Salvia miltiorrhiza, belonging to the largest and most widely distributed genus in the mint family, is a model medicinal plant with ..
  63. Parajuli D, Park E, Che X, Jiang W, Kim Y, Sohn D, et al. PF2401-SF, standardized fraction of Salvia miltiorrhiza, induces apoptosis of activated hepatic stellate cells in vitro and in vivo. Molecules. 2013;18:2122-34 pubmed publisher
    ..Our data suggest that PF2401-SF can mediate HSCs apoptosis induction, and may be a potential herbal medicine for the treatment of liver fibrosis...
  64. Liu S, Sun Y, Chen H, Song S, Xu Y. Magnetic screening of the potential targeted protein of salvianolic acid B using T7 phage display library. Appl Biochem Biotechnol. 2010;162:1206-13 pubmed publisher
    Salvianolic acid B is one of the effective components from the Chinese traditional drug Salvia miltiorrhiza (Danshen), which is widely used as a usual clinic drug for atherosclerosis-related disorder patients in China...
  65. Gu C, Qiao J, Zhu M, Du J, Shang W, Yin W, et al. Preliminary evaluation of the interactions of Panax ginseng and Salvia miltiorrhiza Bunge with 5-fluorouracil on pharmacokinetics in rats and pharmacodynamics in human cells. Am J Chin Med. 2013;41:443-58 pubmed publisher
    ..The effects of extracts from Panax ginseng (PGS) and Salvia miltiorrhiza Bunge (SMB) on the pharmacokinetics of 5-fluorouracil (5-FU) were performed in vivo and detected by high ..
  66. Wenping H, Yuan Z, Jie S, Lijun Z, Zhezhi W. De novo transcriptome sequencing in Salvia miltiorrhiza to identify genes involved in the biosynthesis of active ingredients. Genomics. 2011;98:272-9 pubmed publisher
    Medicinal Salvia miltiorrhiza is a Chinese herb commonly used for treating cardiovascular diseases and neuroasthenic insomnia. However, little is known at the genetics level about how its compounds are synthesized in that plant...
  67. Li Y, Sun C, Luo H, Li X, Niu Y, Chen S. [Transcriptome characterization for Salvia miltiorrhiza using 454 GS FLX]. Yao Xue Xue Bao. 2010;45:524-9 pubmed
    To investigate the profile of gene expression in Salvia miltiorrhiza and elucidate its functional gene, 454 GS FLX platform and Titanium regent were used to produce a substantial expressed sequence tags (ESTs) dataset from the root of S...
  68. Sferra R, Vetuschi A, Catitti V, Ammanniti S, Pompili S, Melideo D, et al. Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation. Eur Rev Med Pharmacol Sci. 2012;16:1484-98 pubmed
    ..Transforming growth factor-beta1 (TGF-beta)/Smad3 signalling plays a major role in tissue fibrogenesis acting as a potent stimulus of ECM accumulation...
  69. Wang W, Jiang X, Zhang L, Chen P, Shen Y, Huang L. [Isolation and characteristic of SmbHLH1 gene in Salvia miltiorrhiza]. Zhongguo Zhong Yao Za Zhi. 2011;36:3416-20 pubmed
    A novel bHLH-like gene, designated SmbHLH1, was isolated from Salvia miltiorrhiza, in order to identify a bHLH gene in related to danshinone biosysnthesis.
  70. Li X, Wang W, Zhou G, Li Y, Xie X, Zhou T. Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process. Molecules. 2012;17:2388-407 pubmed publisher
    ..acid B (SaB), dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA, in roots of Salvia miltiorrhiza (Dashen) during the drying process at different oven temperatures...
  71. Hung Y, Wang P, Pan T. Functional proteomics reveal the effect of Salvia miltiorrhiza aqueous extract against vascular atherosclerotic lesions. Biochim Biophys Acta. 2010;1804:1310-21 pubmed publisher
    b>Salvia miltiorrhiza is a Chinese herb widely used for cardiovascular disorder regimens, yet little is known about the cellular mechanisms that contribute to attenuated growth of smooth muscle cells (SMCs) under oxidative stress such as ..
  72. Jia Y, Huang F, Zhang S, Leung S. Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials. Int J Cardiol. 2012;157:330-40 pubmed publisher
    ..This study aims to provide a comprehensive and PRISMA-compliant systematic review with sensitivity and subgroup analyses...
  73. Ji K, Chai J, Xing C, Nan J, Yang P, Tang J. Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment. J Zhejiang Univ Sci B. 2010;11:618-26 pubmed publisher
    ..72+/-6.10), (17.02+/-6.82), (3.73+/-2.26) vs. (228.71+/-41.53) pg/ml, all P<0.01] in Ox-LDL treated EPCs. These results suggest that Danshen may exert a protective effect through its antioxidant and anti-inflammatory features...
  74. Dai Z, Cui G, Zhou S, Zhang X, Huang L. Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation. J Plant Physiol. 2011;168:148-57 pubmed publisher
    ..FJ747636) was isolated from Salvia miltiorrhiza by rapid amplification of cDNA ends (RACE). The cloned gene was then transformed into the hairy root of S...
  75. Yu H, Subedi R, Nepal P, Kim Y, Choi H. Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza. Arch Pharm Res. 2012;35:1457-64 pubmed publisher
    Cryptotanshinone, tanshinone I and tanshinone IIA are three major components in the extract of Salvia miltiorrhiza with pharmacological significance...
  76. Zhang X, Song Z, Xu J, Ma Z. Improving the NQO1-inducing activities of phenolic acids from radix Salvia miltiorrhiza: a methylation strategy. Chem Biol Drug Des. 2011;78:558-66 pubmed publisher
    ..86 ± 2.34 ?g/mL and 11.97 ± 0.60 ?g/mL, respectively. The findings indicated that methylation is an effective strategy to improve the NQO1-inducing activities of phenolic acids in Danshen. ..
  77. Zhang C, Yi Y, Hao K, Liu G, Wang G. Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa--towards identification of algicidal substance and determination of inhibition mechanism. Chemosphere. 2013;93:997-1004 pubmed publisher
    The present study was to isolate and identify a potent algicidal compound from extract of Salvia miltiorrhiza and study the potential inhibition mechanism on Microcystis aeruginosa...