perilla

Summary

Summary: A plant genus of the family LAMIACEAE that is a source of perilla alcohol and the oil is rich in alpha-linolenic acid (alpha-18:3).

Top Publications

  1. Sompornpailin K, Makita Y, Yamazaki M, Saito K. A WD-repeat-containing putative regulatory protein in anthocyanin biosynthesis in Perilla frutescens. Plant Mol Biol. 2002;50:485-95 pubmed
    ..study, we have isolated a cDNA encoding a novel WD-repeat protein, PFWD, from the anthocyanin-pigmented leaves of Perilla frutescens using AN11 cDNA from Petunia hybrida as the probe...
  2. Hoffmann Benning S, Gage D, McIntosh L, Kende H, Zeevaart J. Comparison of peptides in the phloem sap of flowering and non-flowering Perilla and lupine plants using microbore HPLC followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Planta. 2002;216:140-7 pubmed
    ..We detected more than 100 components in the phloem sap of Perilla ocymoides L. and Lupinus albusL. Sequences for 16 peptides in a mass range from 1 to 9 kDa were obtained...
  3. Ohara K, Ujihara T, Endo T, Sato F, Yazaki K. Limonene production in tobacco with Perilla limonene synthase cDNA. J Exp Bot. 2003;54:2635-42 pubmed
    ..In an attempt to engineer monoterpene biosynthesis, three expression constructs of LS cDNA of Perilla frutescens, which were designed to be localized in either the plastid, the cytosol or the endoplasmic reticulum (..
  4. Gulcin I, Berashvili D, Gepdiremen A. Antiradical and antioxidant activity of total anthocyanins from Perilla pankinensis decne. J Ethnopharmacol. 2005;101:287-93 pubmed
    The purpose of this work comprise the assessment of the antioxidant activity of total anthocyanins from Perilla pankinensis samples (TAPP) by different analytical methods: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, ..
  5. Chung K, Hwang S, Hahn B, Kim K, Kim J, Kim Y, et al. Authentic seed-specific activity of the Perilla oleosin 19 gene promoter in transgenic Arabidopsis. Plant Cell Rep. 2008;27:29-37 pubmed
    The Perilla (Perilla frutescens L. cv. Okdong) oleosin gene, PfOle19, produces a 19-kDa protein that is highly expressed only in seeds...
  6. Kim M, Kim H. Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet. Phytother Res. 2009;23:1685-90 pubmed publisher
    The objective of this study was to evaluate the antiobesity effect of perilla leaf extract (PLE) in animal models of high fat diet-induced obesity...
  7. Zhao G, Yao Yue C, Qin G, Guo L. Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons. Neurobiol Aging. 2012;33:176-86 pubmed publisher
    ..The present results showed that luteolin, isolated from the ripe seed of Perilla frutescens (L.) Britt...
  8. Bae J, Lee J, Shin M, Lee S, Hwang I. Effect of wash treatments on reducing human norovirus on iceberg lettuce and perilla leaf. J Food Prot. 2011;74:1908-11 pubmed publisher
    ..This study used artificially contaminated vegetables (iceberg lettuce and perilla leaf), and washing was done with tap water for convenience...
  9. Chen J, Xia Z, Tan R. High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens. J Pharm Biomed Anal. 2003;32:1175-9 pubmed
    b>Perilla frutescens (L.) Britt. (Lamiaceae), a famous traditional Chinese medicine, has been used for the treatment of various diseases. To evaluate the quality of P...

More Information

Publications113 found, 100 shown here

  1. Ito M, Honda G. Geraniol synthases from perilla and their taxonomical significance. Phytochemistry. 2007;68:446-53 pubmed
    Geraniol synthases were isolated from five pure strains of Perilla citriodora and Perilla frutescens which vary in essential oil type, the main compounds of which were citral, elsholtziaketone, perillaketone, and perillene, respectively...
  2. Liao B, Hao Y, Lu J, Bai H, Guan L, Zhang T. Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids. BMC Genomics. 2018;19:213 pubmed publisher
    b>Perilla frutescens is well known for its high ?-linolenic acid (ALA) accumulation in seeds and medicinal values as well as a source of edible and general-purpose oils...
  3. Kim E, Choi H, Chung T, Choi J, Kim H, Jung Y, et al. Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins. J Pharmacol Sci. 2016;131:259-66 pubmed publisher
    The leaves and stems of Perilla frutescens var. acuta Kudo (PF) have been used to prevent threatened abortion in traditional medicine in the East Asian countries...
  4. Bae J, Han M, Shin H, Kim M, Shin C, Lee D, et al. Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin. J Ethnopharmacol. 2017;195:334-342 pubmed publisher
    b>Perilla frutescens (L.) Britt. (Lamiaceae) is a traditional herb that is consumed in East Asian countries as a traditional medicine...
  5. Kim J, Ro E, Yoon K. Comparison of Growth Kinetics of Various Pathogenic E. coli on Fresh Perilla Leaf. Foods. 2013;2:364-373 pubmed publisher
    Growth kinetics for Escherichia coli O157:H7 in perilla leaves were compared to those of pathogenic E...
  6. Feng W, Ishiguro Y, Hotta K, Watanabe H, Suga H, Kageyama K. Simple detection of Pythium irregulare using loop-mediated isothermal amplification assay. FEMS Microbiol Lett. 2015;362: pubmed publisher
    ..A 'Bait-LAMP' method using the supernatant of autoclaved perilla seeds incubated in a soil/water mixture for 1 week at 25°C successfully detected P. irregulare from the soil...
  7. Jeong S, Kim O, Yoo S, Seo C, Kim Y, Shin H. Anti?inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi?san via enhancement of heme oxygenase?1 expression in RAW264.7 macrophages. Mol Med Rep. 2016;13:4365-71 pubmed publisher
    Gwakhyangjeonggi?san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, ..
  8. Abd El Hafeez A, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, et al. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma. Cytotechnology. 2018;70:913-919 pubmed publisher
    ..We have previously shown that a methoxyflavanone derivative from the Asian medicinal herb Perilla frutescens (Perilla-derived methoxyflavanone; PDMF) shows a prominent anti-tumor activity against A549 human lung ..
  9. Xuan T, Gangqiang G, Minh T, Quy T, Khanh T. An Overview of Chemical Profiles, Antioxidant and Antimicrobial Activities of Commercial Vegetable Edible Oils Marketed in Japan. Foods. 2018;7: pubmed publisher
    ..whilst the percentage of lipid peroxidation inhibition (LPI%) in sunflower, canola, cotton, grape, flax, perilla, Inca inchi, perillartine, and rice bran were significantly higher than other oils...
  10. Roellecke K, Jäger V, Gyurov V, Kowalski J, Mielke S, Rettie A, et al. Ligand characterization of CYP4B1 isoforms modified for high-level expression in Escherichia coli and HepG2 cells. Protein Eng Des Sel. 2017;30:205-216 pubmed publisher
    ..of the furan analogs by the purified recombinant CYP4B1 variants were analyzed: the naturally occurring perilla ketone was found to be the tightest binder to CYP4B1, but also the analog that was most extensively metabolized ..
  11. Hwang S, Kwon S, Kang Y, Lee J, Lim S. Rapid High Performance Liquid Chromatography Determination and Optimization of Extraction Parameters of the α-Asarone Isolated from Perilla frutescens L. Molecules. 2017;22: pubmed publisher
    ..mL/g), extraction time (1-3 h), and ethanol concentration (50%-100%) for maximum content of α-asarone from Perilla frutescens (PF) extract. Experimental values of α-asarone were 9.51-46...
  12. Shi H, Luo X, Wu R, Yue X. Production of eicosapentaenoic acid by application of a delta-6 desaturase with the highest ALA catalytic activity in algae. Microb Cell Fact. 2018;17:7 pubmed publisher
    ..12 ± 4.78%. The EPA yield was further increased to 554.3 ± 95.6 mg/L by supplementation with 4 g/L perilla seed meal (PeSM), 500 mg/L MI, and 12% CO2 aeration with glucose/KNO3 at varying ..
  13. Peiretti P. Effects of Dietary Fatty Acids on Lipid Traits in the Muscle and Perirenal Fat of Growing Rabbits Fed Mixed Diets. Animals (Basel). 2012;2:55-67 pubmed publisher
    ..to evaluate the effects of various raw materials (spirulina, curcuma, tomato pomace, false flax, linseed, chia, perilla seeds) as suitable polyunsaturated fatty acid n-3 (n-3 PUFA) sources, on the lipid traits in the longissimus ..
  14. Chen C, Leu Y, Fang Y, Lin C, Kuo L, Sung W, et al. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium. Sci Rep. 2015;5:18204 pubmed publisher
    The leaves of Perilla frutescens (L.) Britt. have been traditionally used as an herbal medicine in East Asian countries to treat a variety diseases. In this present study, we investigated the inhibitory effects of P...
  15. Skowyra M, Falguera V, Azman N, Segovia F, Almajano M. The Effect of Perilla frutescens Extract on the Oxidative Stability of Model Food Emulsions. Antioxidants (Basel). 2014;3:38-54 pubmed publisher
    The polyphenolic profile of leaves and stalks of Perilla frutescens, was assessed as a source of natural antioxidants. The amount of caffeic and rosmarinic acids, determined by high-performance liquid chromatography (HPLC), were 0...
  16. Liao K, Yan J, Li S, Wang T, Xu W, Mai K, et al. Molecular cloning and characterization of unfolded protein response genes from large yellow croaker (Larimichthys crocea) and their expression in response to dietary fatty acids. Comp Biochem Physiol B Biochem Mol Biol. 2017;203:53-64 pubmed publisher
    ..sources (various fatty acids) such as fish oil (FO), palmic acid (PA), olive oil (OO), sunflower oil (SO), and perilla oil (PO), were examined following feeding...
  17. Jin C, Park H, So Y, Nam B, Han S, Kim J. Comparison of the Anti-Inflammatory Activities of Supercritical Carbon Dioxide versus Ethanol Extracts from Leaves of Perilla frutescens Britt. Radiation Mutant. Molecules. 2017;22: pubmed publisher
    ..to compare supercritical carbon dioxide extraction and ethanol extraction for isoegomaketone (IK) content in perilla leaf extracts and to identify the optimal method...
  18. Ide T, Tanaka A. ?-Lipoic acid ameliorated oxidative stress induced by perilla oil, but the combination of these dietary factors was ineffective to cause marked deceases in serum lipid levels in rats. Nutr Res. 2017;48:49-64 pubmed publisher
    Dietary perilla oil rich in ?-linolenic acid and ?-lipoic acid lowers the serum lipid level through changes in hepatic fatty acid metabolism...
  19. Flaiz L, Freire M, Cofrades S, Mateos R, Weiss J, Jimenez Colmenero F, et al. Comparison of simple, double and gelled double emulsions as hydroxytyrosol and n-3 fatty acid delivery systems. Food Chem. 2016;213:49-57 pubmed publisher
    ..systems, namely simple emulsion, double emulsion and gelled double emulsion, for delivery of n-3 fatty acids (perilla oil at 300g/kg) and hydroxytyrosol (300mg/kg)...
  20. Kamei R, Fujimura T, Matsuda M, Kakihara K, Hirakawa N, Baba K, et al. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions. Biochem Biophys Res Commun. 2017;483:674-679 pubmed publisher
    b>Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P...
  21. Park S, Kang M, Choi Y, Kim Y, Antika L, Kim D, et al. α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy. Oncotarget. 2017;8:7370-7383 pubmed publisher
    ..This study examined that α-asarone present in purple perilla abrogated macrophage injury caused by oxysterols via ER stress- and autophagy-mediated mechanisms...
  22. Tian H, Qu S, Wang Y, Lu Z, Zhang M, Gan Y, et al. Calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans. Appl Microbiol Biotechnol. 2017;101:3335-3345 pubmed publisher
    ..Perillaldehyde (PAE) is a natural monoterpenoid compound derived from Perilla frutescens. The minimum inhibitory concentration of PAE against C. albicans was 0.4 ?L/mL...
  23. Fujiwara Y, Ito M. Molecular cloning and characterization of a Perilla frutescens cytochrome P450 enzyme that catalyzes the later steps of perillaldehyde biosynthesis. Phytochemistry. 2017;134:26-37 pubmed publisher
    b>Perilla produces the cyclohexanoid monoterpene perillaldehyde as a major constituent of an essential oil that is accumulated in its glandular trichomes...
  24. Li P, Qi Z, Liu L, Ohi Toma T, Lee J, Hsieh T, et al. Molecular phylogenetics and biogeography of the mint tribe Elsholtzieae (Nepetoideae, Lamiaceae), with an emphasis on its diversification in East Asia. Sci Rep. 2017;7:2057 pubmed publisher
    Elsholtzia and its allied genera such as Collinsonia and Perilla (tribe Elsholtzieae, Lamiaceae) are an ecologically and economically important plant group consisting of ~71 species, with most species distributed in East and Southeast ..
  25. Jung S, Lee C, Lee J, Yong H, Yum S, Jeong H, et al. Increase in nitrite content and functionality of ethanolic extracts of Perilla frutescens following treatment with atmospheric pressure plasma. Food Chem. 2017;237:191-197 pubmed publisher
    ..Ethanolic extracts of Perilla frutescens (EEP) were prepared and treated with APP for 60min. Nitrite content increased from 0 to 45...
  26. Freire M, Bou R, Cofrades S, Jimenez Colmenero F. Technological characteristics of cold-set gelled double emulsion enriched with n-3 fatty acids: Effect of hydroxytyrosol addition and chilling storage. Food Res Int. 2017;100:298-305 pubmed publisher
    ..the technological characteristics and microbiological content of gelled double emulsions (GDE) formulated with perilla oil (as lipid phase and source of n-3 fatty acids) combined or not with hydroxytyrosol (Hyt) (in the inner ..
  27. Lee K, Lee Y, Kim E, Lee S, Roh K, Kim J, et al. Functional identification of oleate 12-desaturase and ?-3 fatty acid desaturase genes from Perilla frutescens var. frutescens. Plant Cell Rep. 2016;35:2523-2537 pubmed
    ..expression, subcellular localization, and functions of genes that encode fatty acid desaturase enzymes in Perilla frutescens var. frutescens. Perilla (Perilla frutescens var...
  28. He Y, Nie E, Li C, Ye Q, Wang H. Uptake and subcellular distribution of triclosan in typical hydrophytes under hydroponic conditions. Environ Pollut. 2017;220:400-406 pubmed publisher
    ..triclosan (TCS) to investigate uptake and distribution of TCS in six aquatic plants (water spinach, purple perilla, cress, penny grass, cane shoot, and rice), and the subcellular distribution of 14C-TCS was determined ..
  29. Yu H, Qiu J, Ma L, Hu Y, Li P, Wan J. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol. 2017;108:375-391 pubmed publisher
    b>Perilla frutescens (L.) Britt., a worldwide distributed plant, is an important economic crop and with a long cultivation history in China as well as some other countries in Asia. Except for the edible applications, the plant of P...
  30. Tripathi C, Gupta N, Kumar P, Singh A, Raj V, Parashar P, et al. ?-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation. AAPS PharmSciTech. 2018;19:1205-1218 pubmed publisher
    ..to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier...
  31. Park S, Kang M, Choi Y, Kim Y, Antika L, Lim S, et al. Dietary compound ?-asarone alleviates ER stress-mediated apoptosis in 7?-hydroxycholesterol-challenged macrophages. Mol Nutr Food Res. 2016;60:1033-47 pubmed publisher
    ..This study determined the inhibitory effect of ?-asarone present in purple perilla, on 7?-hydroxycholesterol-induced macrophage apoptosis, targeting against ER stress signaling pathway...
  32. Nam B, So Y, Kim H, Kim J, Jin C, Han A. A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production. Molecules. 2017;22: pubmed publisher
    The leaves of Perilla frutescens var. crispa (Lamiaceae)-known as 'Jureum-soyeop' or 'Cha-jo-ki' in Korean, 'ZI SU YE' in Chinese, and 'Shiso' in Japan-has been used as a medicinal herb...
  33. Xu J, Dong L, Wang R, Niu W, Zhang N, Naoki F, et al. [Soil improvement promoted micro-ecology of farmlands for ginseng cultivation]. Zhongguo Zhong Yao Za Zhi. 2017;42:875-881 pubmed publisher
    ..process of soil improvement was described as follows? soil was sterilized using trichloronitromethane, and then perilla seeds were planted...
  34. Dai L, Zhong L, Cao Y, Chen W, Cheng Y, Lin X, et al. Efficacy and safety of Yirui capsule in patients with hyperlipidemia: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial. Trials. 2016;17:291 pubmed publisher
    ..The main ingredients of the Yirui capsule are perilla oil, Folium Ginkgo (Yinxingye), Radix Salviae miltiorrhizae (Danshen), Fructus Crataegi (Shanzha), Rhizoma ..
  35. Kim Y, Kim A, Jo A, Choi H, Cho S, Choi C. Development of User-Friendly Method to Distinguish Subspecies of the Korean Medicinal Herb Perilla frutescens Using Multiplex-PCR. Molecules. 2017;22: pubmed publisher
    b>Perilla (Perilla frutescens) is an economically and culturally important plant in East Asia...
  36. Ghimire B, Yu C, Chung I. Assessment of the phenolic profile, antimicrobial activity and oxidative stability of transgenic Perilla frutescens L.overexpressing tocopherol methyltransferase (?-tmt) gene. Plant Physiol Biochem. 2017;118:77-87 pubmed publisher
    ..the effects of enhanced concentrations of ?-tocopherol and phenolic compounds on the resistance and stability of Perilla oil in transgenic Perilla frutescens plants against various tested pathogenic bacteria by over-expressing the ?-..
  37. Hobbs C, Taylor S, Beevers C, Lloyd M, Bowen R, Lillford L, et al. Genotoxicity assessment of the flavouring agent, perillaldehyde. Food Chem Toxicol. 2016;97:232-242 pubmed publisher
    Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods...
  38. Kim M, Kim S. Minimization of diauxic growth lag-phase for high-efficiency biogas production. J Environ Manage. 2017;187:456-463 pubmed publisher
    ..and skim milk) showed a single step digestion process and low-carbohydrate and high-fat ABPs (bean curd and perilla seed) showed a two-step digestion process...
  39. Kim H, Choi N, Oh S, Kim Y, Hee Kim B, Kim I. Synthesis of ?-linolenic acid-rich triacylglycerol using a newly prepared immobilized lipase. Food Chem. 2017;237:654-658 pubmed publisher
    An ?-linolenic acid (ALA)-rich triacylglycerol (TAG) was synthesized from an ALA-rich fatty acid (FA) from perilla oil and glycerol, using a newly prepared immobilized lipase under vacuum...
  40. Li J, Li Z, Gu L, Choi K, Kim D, Kim H, et al. The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone. J Nat Med. 2018;72:96-105 pubmed publisher
    This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P...
  41. Zhang T, Song C, Song L, Shang Z, Yang S, Zhang D, et al. RNA Sequencing and Coexpression Analysis Reveal Key Genes Involved in ?-Linolenic Acid Biosynthesis in Perilla frutescens Seed. Int J Mol Sci. 2017;18: pubmed publisher
    i>Perillafrutescen is used as traditional food and medicine in East Asia. Its seeds contain high levels of ?-linolenic acid (ALA), which is important for health, but is scarce in our daily meals...
  42. Chung M, Bae W, Choi S, Lee K, Jeong H, Bashraheel F, et al. An Asian traditional herbal complex containing Houttuynia cordata Thunb, Perilla frutescens Var. acuta and green tea stimulates hair growth in mice. BMC Complement Altern Med. 2017;17:515 pubmed publisher
    ..used in Asia for the treatment of patients with alopecia, usually in combination with other two herbal medicines (Perilla frutescens var. acuta (PFVA) and green tea (GT))...
  43. Sharifan P, Hosseini M, Sharifan A. The interventional relationship between frequent fish consumption and depression symptoms in aging adults: a randomized controlled trial. Int J Geriatr Psychiatry. 2017;32:e116-e122 pubmed publisher
    ..was intended to test the hypothesis that the elderly provided with the frequent consumption of fishes marinated in essential oil of Perilla frutescens (EOPF) or not would experience fewer depressive symptoms after 6 months.
  44. Alagawany M, Abd El Hack M, Farag M, Gopi M, Karthik K, Malik Y, et al. Rosmarinic acid: modes of action, medicinal values and health benefits. Anim Health Res Rev. 2017;:1-10 pubmed publisher
    ..RA is a natural polyphenol present in several Lamiaceae herbs like Perilla frutescens, and RA is becoming an integral component of animal nutrition as it counters the effect of reactive ..
  45. Deng K, Fan Y, Ma T, Wang Z, TanTai W, Nie H, et al. Carcass traits, meat quality, antioxidant status and antioxidant gene expression in muscle and liver of Hu lambs fed perilla seed. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    The effects of perilla (Perilla frutescens L.) seed on carcass traits, meat quality, antioxidant status and antioxidant gene expression in the liver and muscle of Hu lambs were investigated in this study. Sixty Hu lambs (23.02 ± 1...
  46. Jin C, So Y, Nam B, Han S, Kim J. Isoegomaketone Alleviates the Development of Collagen Antibody-Induced Arthritis in Male Balb/c Mice. Molecules. 2017;22: pubmed publisher
    In this study, we attempted to identify and assess effects of isoegomaketone (IK) isolated from Perilla frutescens var. crispa on the development of rheumatoid arthritis (RA)...
  47. Lee Y, Kim B, Kim S, Kim M, Kim H, Hwang S, et al. Characterization of metabolite profiles from the leaves of green perilla (Perilla frutescens) by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry and screening for their ant. J Food Drug Anal. 2017;25:776-788 pubmed publisher
    ..research was to access the determination of metabolite profiles and antioxidant properties in the leaves of green perilla (Perilla frutescens), where these are considered functional and nutraceutical substances in Korea...
  48. Zhang C, Wei C, Zhang F, Tian J, Chen A, Guo B. [Morphological characteristics of Chinese Perilla fruits]. Zhongguo Zhong Yao Za Zhi. 2017;42:1113-1118 pubmed publisher
    The morphological traits of 55 Chinese Perilla fruit samples (size, 100 grains weight, color, hardness, surface ridge height) are described and the statistically analyzed...
  49. Niazi N, Bibi I, Shahid M, Ok Y, Burton E, Wang H, et al. Arsenic removal by perilla leaf biochar in aqueous solutions and groundwater: An integrated spectroscopic and microscopic examination. Environ Pollut. 2018;232:31-41 pubmed publisher
    In this study, we examined the removal of arsenite (As(III)) and arsenate (As(V)) by perilla leaf-derived biochars produced at 300 and 700 °C (referred as BC300 and BC700) in aqueous environments...
  50. Shen Q, Zhang D, Sun W, Zhang Y, Shang Z, Chen S. [Medicinal plant DNA marker assisted breeding (?) the assistant identification of SNPs assisted identification and breeding research of high yield Perilla frutescens new variety]. Zhongguo Zhong Yao Za Zhi. 2017;42:1668-1672 pubmed publisher
    b>Perilla frutescens is one of 60 kinds of food and medicine plants in the initial directory announced by health ministry of China...
  51. Kang W, Seo M, Shin K, Park J, Oh D. Gene cloning of an efficiency oleate hydratase from Stenotrophomonas nitritireducens for polyunsaturated fatty acids and its application in the conversion of plant oils to 10-hydroxy fatty acids. Biotechnol Bioeng. 2017;114:74-82 pubmed publisher
    ..The enzyme converted soybean oil and perilla seed oil hydrolyzates containing 10?mM total unsaturated fatty acids, including OA, LA, and ALA, to 8.87 and 8...
  52. Abd El Hafeez A, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, et al. A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma. Cytotechnology. 2018;70:899-912 pubmed publisher
    b>Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P...
  53. Ito M. [Research and educational activities through perspective of pharmacognosy]. Yakugaku Zasshi. 2010;130:687-95 pubmed
    ..Some of the results and experiences gathered in these projects are described in this article for discussion of the future image of the pharmacognosial field...
  54. Tian J, Bae Y, Choi N, Kang D, Heu S, Lee S. Survival and growth of foodborne pathogens in minimally processed vegetables at 4 and 15 °C. J Food Sci. 2012;77:M48-50 pubmed publisher
    ..Vegetables (romaine lettuce, iceberg lettuce, perilla leaves, and sprouts) were inoculated with 4 pathogens (Salmonella enterica serovar Typhimurium, Staphylococcus ..
  55. Liu R, Zhang J, Mou Z, Hao S, Zhang Z. Microwave-assisted one-step extraction-derivatization for rapid analysis of fatty acids profile in herbal medicine by gas chromatography-mass spectrometry. Analyst. 2012;137:5135-43 pubmed publisher
    ..The simplicity, speed and practicality of this method indicates great potential for high throughput analysis of fatty acids in natural medicinal samples...
  56. Kurowska E, Dresser G, Deutsch L, Vachon D, Khalil W. Bioavailability of omega-3 essential fatty acids from perilla seed oil. Prostaglandins Leukot Essent Fatty Acids. 2003;68:207-12 pubmed
    ..assess the effect of Entrox coating on the short-term bioavailability of ALA administered in the form of ALA-rich Perilla seed oil, 12 healthy subjects (6 males and 6 females) received in a random order Entrox-coated and non-coated ALA ..
  57. Clark S, Zhong L, Filiault D, Perman S, Ren Z, Gould M, et al. Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. Clin Cancer Res. 2003;9:4494-504 pubmed
    ..Because signaling through Ras is necessary for Bcr/Abl transformation, we examined whether POH induces its anti-leukemia effect by inhibiting Ras signaling...
  58. Cui K, Ding X, Xiao G, Dai J. [Analysis of triacylglycerol composition of perilla oil by combination of non-aqueous reversed-phase high performance liquid chromatography with gas chromatography]. Se Pu. 1997;15:470-3 pubmed
    b>Perilla oil was verified to be a rich source of polyunsaturated fatty acid (PUFA). Its linolenic content is 64.82%, the highest in the plants...
  59. Gu L, Wu T, Zhang Z, Chou G, Wang Z. [Evaluation of antioxidant activity of Radix Linderae and other two Chinese drugs using TLC-bioautography]. Yao Xue Xue Bao. 2006;41:956-62 pubmed
    ..To evaluate the antioxidant capacity and quality of traditional Chinese medicines using TLC-bioautography...
  60. Ito M, Honda G, Sydara K. Perilla frutescens var. frutescens in northern Laos. J Nat Med. 2008;62:251-8 pubmed publisher
    Twenty-eight samples of mericarps of Perilla frutescens var. frutescens were collected through fieldwork performed in Phongsali and Xieng Khouang provinces in northern Laos...
  61. Bumblauskiene L, Jakstas V, Janulis V, Mazdzieriené R, Ragazinskiene O. Preliminary analysis on essential oil composition of Perilla L. cultivated in Lithuania. Acta Pol Pharm. 2009;66:409-13 pubmed
    This study represents the investigation of the essential oil of Perilla frutescens (L.) Britton, Perilla frutescens (L.) Britton var. crispa f. viridis, Perilla ocymoides L. var...
  62. Nakashima Y, Sato A, Saito M. Effect of plant- and fish-oil derived n-3 polyunsaturated fatty acids on counteraction of n-3 fatty acid shortage in adult rats fed a lard diet. J Nutr Sci Vitaminol (Tokyo). 2009;55:346-52 pubmed
    ..1 and 2, two groups of rats received the LD (LD group) and the fish-oil diet (FD; FD group), and the LD and the perilla-oil diet (PD; PD group), respectively (dietary treatment period). After 6 wk, 6 rats per group were sacrificed...
  63. Masumoto N, Korin M, Ito M. Geraniol and linalool synthases from wild species of perilla. Phytochemistry. 2010;71:1068-75 pubmed publisher
    Geraniol and linalool synthases were isolated from three pure strains of Perilla hirtella and Perilla setoyensis, which are wild species of perilla...
  64. Takenaka Y, Arii Y, Masui H. Network structure and forces involved in perilla globulin gelation: comparison with sesame globulin. Biosci Biotechnol Biochem. 2011;75:1198-200 pubmed
    Scanning electron micrographs show that perilla globulin gel had a finer network structure than sesame ?-globulin gel. The effects of various reagents on the gel formation and solubility of perilla and sesame gels were compared...
  65. Liu W, Zhang J, Lu L, Shi F, Niu D, Wang D, et al. Effects of perilla extract on productive performance, serum values and hepatic expression of lipid-related genes in Shaoxing ducks. Br Poult Sci. 2011;52:381-7 pubmed publisher
    1. The aim of this study was to identify the effect of perilla extract, a source of polyunsaturated fatty acids, on lipid metabolism and expression of lipid-related genes in livers of Shaoxing ducks. 2...
  66. Al Mahmud M, Rahman M, Na T, Park J, Yang A, Park K, et al. A QuEChERS-based extraction method for the residual analysis of pyraclofos and tebufenpyrad in perilla leaves using gas chromatography: application to dissipation pattern. Biomed Chromatogr. 2013;27:156-63 pubmed publisher
    ..this work was to establish a simple extraction method for the residual analysis of pyraclofos and tebufenpyrad in Perilla leaves...
  67. Masaki Y, Izumi Y, Matsumura A, Akaike A, Kume T. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. Eur J Pharmacol. 2017;798:26-34 pubmed publisher
    ..Previously, we have isolated 2',3'-dihydroxy-4',6'-dimethoxychalcone (DDC) from green perilla leaves as an activator of the Nrf2-ARE pathway...
  68. Barcelo Coblijn G, Kitajka K, Puskas L, Hogyes E, Zvara A, Hackler L, et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. Biochim Biophys Acta. 2003;1632:72-9 pubmed
    ..2:1 or a rat chow supplemented with a mixture of perilla and soy bean oil giving a ratio of LA to LNA of 4.7:1. Fat content of the feed was 5%...
  69. Kim K, Park S, Choung M. Nondestructive determination of oil content and fatty acid composition in perilla seeds by near-infrared spectroscopy. J Agric Food Chem. 2007;55:1679-85 pubmed
    ..as a rapid and nondestructive method to determine the oil content and fatty acid composition in intact seeds of perilla [Perilla frutescens var. japonica (Hassk.) Hara] germplasms in Korea...
  70. Ukai M, Kameya H, Nakamura H, Shimoyama Y. An electron spin resonance study of dry vegetables before and after irradiation. Spectrochim Acta A Mol Biomol Spectrosc. 2008;69:1417-22 pubmed
    ..0030 of the irradiated DV increased lineally with radiation doses. Progressive saturation behavior of the DV indicates a unique saturation and the signals obeyed various relaxation processes...
  71. Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, et al. Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol Pharm Bull. 2008;31:1376-80 pubmed
    Rosmarinic acid (RA) is one of major polyphenolic ingredients of Perillae Herba (a leaf of Perilla frutescens), and has an antidepressant-like property in animal models of depression...
  72. Jung D, Lee M, Yoon S, Jung M. A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. J Food Sci. 2011;76:C891-9 pubmed publisher
    ..3% and 106.3%, respectively. The total PC contents in the vegetable oils varied from 3.01 to 427.83 mg/kg oil. Perilla seed, grape seed, and rice bran oils were found to be highly rich sources of PCs, containing 427.83, 245...
  73. Chen S, Lv G, Huang M, Su J, Fang H, Mou X. [Effects of three traditional Chinese medicine with pungent-flavor, warm-nature and meridian tropism in lung on lung-yang deficiency rats induced by compound factors]. Zhongguo Zhong Yao Za Zhi. 2011;36:1512-5 pubmed
    ..To observe the effects of three traditional Chinese medicine (TCM) such as Amomi Fructus Rotundus, Perillae Folium and Angelicae Dahuricae Radix on lung-yang deficiency rats induced by compound factors...
  74. Jung D, Yoon S, Jung M. Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. J Food Sci. 2012;77:C1249-55 pubmed publisher
    The chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods (supercritical carbon dioxide [SC-CO(2)], mechanical press, and solvent extraction) were studied...
  75. Sumino M, Saito Y, Ikegami F, Hirasaki Y, Namiki T. Efficient preparation of Hangekobokuto (Banxia-Houpo-Tang) decoction by adding perilla herb before decoction is finished. Nat Prod Commun. 2012;7:1619-22 pubmed
    ..medicine used mostly for anxiety disorder and consists of Pinellia Tuber, Poria Sclerotium, Magnolia Bark, Perilla Herb and Ginger...
  76. Zhao Y, Wang Y, Yang J, Liu D. [A study on the rotation of crops among Panax quinquefolium, Perilla frutescens and Coix lacryma-jobi]. Zhongguo Zhong Yao Za Zhi. 2005;30:12-5 pubmed
    ..To provide evidence for establishing an efficient method of growing Panax quinquefolium by rotation of crops...
  77. Kikuchi J, Hirayama T. Practical aspects of uniform stable isotope labeling of higher plants for heteronuclear NMR-based metabolomics. Methods Mol Biol. 2007;358:273-86 pubmed
    ..In this chapter, we describe the practical aspects of two key NMR technologies: uniform stable labeling of plants and in vitro heteronuclear NMR...
  78. Deng Y, Xie Q, Zhang S, Yao H, Zhang H. Anti-asthmatic effects of Perilla seed oil in the guinea pig in vitro and in vivo. Planta Med. 2007;73:53-8 pubmed
    The aim of this study was to investigate the anti-asthmatic effects of Perilla seed oil in vitro and in vivo in sensitized guinea pigs. Aerosolized antigen caused an immediate bronchoconstriction...
  79. Park M, Seol N, Chang P, Yoon S, Lee J. Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens?var.?japonica). J Food Sci. 2011;76:C808-16 pubmed publisher
    b>Perilla seeds have more than 60% of ?-linolenic acid, one of omega-3 essential fatty acids...
  80. Ha T, Lee M, Kim H, Kwon H, Baek I, Kubo I, et al. Slow-binding inhibition of soybean lipoxygenase-1 by luteolin. Arch Pharm Res. 2012;35:1811-6 pubmed publisher
    Luteolin, isolated from the seeds of Perilla frutescens (perilla seeds), inhibited the peroxidation of linoleic acid catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1) with an IC(50) of 5.0 M (1.43 ?g/mL) noncompetitively...
  81. Zhao T, Hong S, Lee J, Lee J, Kim I. Impact of roasting on the chemical composition and oxidative stability of perilla oil. J Food Sci. 2012;77:C1273-8 pubmed publisher
    ..regard to certain changes in the chemical components and oxidative stability of oil expelled from the roasted perilla seeds. The roasting times were established differently at each roasting temperature of 180, 200, and 220 °C...
  82. Inoue K, Baba E, Hino T, Oka H. A strategy for high-speed countercurrent chromatography purification of specific antioxidants from natural products based on on-line HPLC method with radical scavenging assay. Food Chem. 2012;134:2276-82 pubmed publisher
    ..In this study, the specific antioxidants in red cabbage, perilla and elderberry pigments were evaluated by on-line HPLC with DPPH radical scavenging assay, and purified by HSCCC ..
  83. Mizuno M, Yurimoto H, Iguchi H, Tani A, Sakai Y. Dominant colonization and inheritance of Methylobacterium sp. strain OR01 on perilla plants. Biosci Biotechnol Biochem. 2013;77:1533-8 pubmed
    ..In a preceding study, we found that perilla plants harbor a dominant population of PPFMs on their leaves and seeds, and that the closest relative of PPFMs (..
  84. Bassoli A, Borgonovo G, Morini G, De Petrocellis L, Schiano Moriello A, Di Marzo V. Analogues of perillaketone as highly potent agonists of TRPA1 channel. Food Chem. 2013;141:2044-51 pubmed publisher
    ..perception of many pungent chemesthetic compounds, which are widespread in spices and food plants, including Perilla frutescens. A natural compound from P...
  85. Izumi Y. [Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves]. Yakugaku Zasshi. 2013;133:983-8 pubmed
    ..Using bioactivity-guided fractionation, we identified 2',3'-dihydroxy-4',6'-dimethoxychalcone (DDC) from green perilla leaves as the activator responsible for the increased activation of the ARE pathway...
  86. Asada T, Koi Y, Arakawa R, Zhu F, Sadaoka M, Tamura H. Isolation techniques for anthocyanidin 3,5-diglucosides and their related chemicals using supramolecules technique, and two solid-phase extraction cartridges. J Chromatogr A. 2014;1351:21-8 pubmed publisher
    ..Secondary, artificial Perilla supramolecules (reconstructed from Perilla crude pigment, flavocommelin and Mg(2+)) result in a high purity of a ..
  87. Freire M, Cofrades S, Serrano Casas V, Pintado T, Jimenez M, Jimenez Colmenero F. Gelled double emulsions as delivery systems for hydroxytyrosol and n-3 fatty acids in healthy pork patties. J Food Sci Technol. 2017;54:3959-3968 pubmed publisher
    ..Effect of partial (MF/GDE sample) and total (LF/GDE) replacement of pork backfat with GDE with perilla oil (PO) as lipid phase and Hxt (in W1) on pork patty composition and properties was evaluated...
  88. Ichihara K, Suda Y. Lipid biosynthesis in developing perilla seeds. Phytochemistry. 2003;63:139-43 pubmed
    In developing seeds of Perilla frutescens var. crispa, the triacylglycerol fraction was found to accumulate between 15 and 19 days after flowering...
  89. Chun O, Kang H, Kim M. Multiresidue method for the determination of pesticides in Korean domestic crops by gas chromatography/mass selective detection. J AOAC Int. 2003;86:823-31 pubmed
    ..an acceptable selectivity for most of the pesticides determined in 3 kinds of samples (Chrysanthemum coronarium; Perilla japonica, leaf; and Lactuca savita, which are very popular vegetables eaten raw in Korea), and very minor ..
  90. Simoniene G, Jurkstiene V, Jankauskiene K, Gailys V, Kevelaitis E, Venskutonis P. [The influence of common perilla (Perilla frutescens (L.) Britton) on non-specific cell-mediated immunity--phagocytosis activity]. Medicina (Kaunas). 2005;41:1042-7 pubmed
    To examine the effect of plant preparations, obtained from Perilla frutescens (L.) Britton introduced in Lithuania, on non-specific cell-mediated immunity.
  91. Adhikari P, Hwang K, Park J, Kim C. Policosanol content and composition in perilla seeds. J Agric Food Chem. 2006;54:5359-62 pubmed
    Policosanols, long-chain alcohols, have many beneficial physiological activities. Contents and compositions in perilla seeds (Perilla frutescens) produced in Korea and China were determined...
  92. Tsuji M, Miyagawa K, Takeuchi T, Takeda H. [Pharmacological characterization and mechanisms of the novel antidepressive- and/or anxiolytic-like substances identified from Perillae Herba]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008;28:159-67 pubmed
    The leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba) are commonly found in traditional oriental herbal medicines, which are primarily used to treat depression and anxiety-related disorders...