marrubium

Summary

Summary: A plant genus of the LAMIACEAE family that contains marrubiin (a labdane diterpene). It is known as a traditional medicinal for sore throat.

Top Publications

  1. Sahpaz S, Hennebelle T, Bailleul F. Marruboside, a new phenylethanoid glycoside from Marrubium vulgare L. Nat Prod Lett. 2002;16:195-9 pubmed
    A new phenylethanoid glycoside, marruboside, has been isolated from the aerial parts of Marrubium vulgare L...
  2. Berrougui H, Isabelle M, Cherki M, Khalil A. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage. Life Sci. 2006;80:105-12 pubmed
    The objective of the present study was to elucidate the beneficial properties of aqueous extracts of Marrubium vulgare (AEM) towards cardiovascular disease by protecting human-LDL against lipid peroxidation and promoting HDL-mediated ..
  3. Herrera Arellano A, Aguilar Santamaría L, García Hernández B, Nicasio Torres P, Tortoriello J. Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics. Phytomedicine. 2004;11:561-6 pubmed
    Cecropia obtusifolia and Marrubium vulgare have been widely used in Mexican traditional medicine for the control of type 2 diabetes...
  4. Sahpaz S, Garbacki N, Tits M, Bailleul F. Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare. J Ethnopharmacol. 2002;79:389-92 pubmed
    The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their anti-inflammatory activity are ..
  5. Kililç M, Yazilcil H, Solak M. A comprehensive study on removal and recovery of copper(II) from aqueous solutions by NaOH-pretreated Marrubium globosum ssp. globosum leaves powder: potential for utilizing the copper(II) condensed desorption solutions in agricultural applications. Bioresour Technol. 2009;100:2130-7 pubmed publisher
    ..ions from aqueous solutions under batch experimental conditions using NaOH-pretreated powdered leaves of Marrubium globosum ssp. globosum plant. Experimental results showed that pH was optimized at the value of 5.5 by 16...
  6. Salama M, Taher E, El Bahy M. Molluscicidal and Mosquitocidal activities of the essential oils of Thymus capitatus Hoff. et Link. and Marrubium vulgare L. Rev Inst Med Trop Sao Paulo. 2012;54:281-6 pubmed
    Steam distillation of essential oils of aerial parts of Thymus capitatus and Marrubium vulgare L. collected at North cost of Egypt yielded 0.5% and 0.2%, respectively...
  7. Sarikurkcu C, Tepe B, Daferera D, Polissiou M, Harmandar M. Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (lamiaceae) by three different chemical assays. Bioresour Technol. 2008;99:4239-46 pubmed
    ..composition and in vitro antioxidant activity of the essential oil and sub-fractions of the methanol extract of Marrubium globosum subsp. globosum...
  8. Rigano D, Formisano C, Basile A, Lavitola A, Senatore F, Rosselli S, et al. Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum. Phytother Res. 2007;21:395-7 pubmed
    b>Marrubium globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae) is a medicinal plant used for the treatment of inflammatory diseases, asthma, coughs and other pulmonary and urinary problems...
  9. Stulzer H, Tagliari M, Zampirolo J, Cechinel Filho V, Schlemper V. Antioedematogenic effect of marrubiin obtained from Marrubium vulgare. J Ethnopharmacol. 2006;108:379-84 pubmed
    This paper describes the antioedematogenic profile of marrubiin (1), the main constituent of Marrubium vulgare, a medicinal plant used in folk medicine of several countries to treat different pathologies...

More Information

Publications63

  1. Zaabat N, Hay A, Michalet S, Darbour N, Bayet C, Skandrani I, et al. Antioxidant and antigenotoxic properties of compounds isolated from Marrubium deserti de Noé. Food Chem Toxicol. 2011;49:3328-35 pubmed publisher
    ..used endemic flora through the analysis of its chemobiodiversity, the phytochemical analysis of aerial parts of Marrubium deserti de Noé was undertaken...
  2. Karioti A, Protopappa A, Megoulas N, Skaltsa H. Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum. Bioorg Med Chem. 2007;15:2708-14 pubmed
    ..Forty-five secondary metabolites isolated from Marrubium velutinum and Marrubium cylleneum belonging to the classes of flavonoids, phenylethanoid glycosides, phenolic ..
  3. Xue X, Sadeghi H, Honarmand A. Three eriophyoid mite species (Acari: Eriophyoidea: Eriophyidae) from Iran. Zootaxa. 2016;4132:403-12 pubmed publisher
    ..They are: Tegolophus marrubiumer sp. nov. on Marrubium vulgare L. (Lamiaceae); Phyllocoptes sp. cf. balasi Farkas, 1962 on Sanguisorba minor Scop. subsp...
  4. Ibrahim A, Hendawy S, Elsayed A, Omer E. Evaluation of hypolipidemic Marrubium vulgare effect in Triton WR-1339-induced hyperlipidemia in mice. Asian Pac J Trop Med. 2016;9:453-9 pubmed publisher
    ..The findings indicated that Marrubium may contain polar products able to lower plasma lipid concentrations and might be beneficial in treatment of ..
  5. Bouterfas K, Mehdadi Z, Aouad L, Elaoufi M, Khaled M, Latreche A, et al. [Does the sampling locality influence on the antifungal activity of the flavonoids of Marrubium vulgare against Aspergillus niger and Candida albicans?]. J Mycol Med. 2016;26:201-11 pubmed publisher
    ..the effect of the sampling locality on the antifungal activity of the flavonoids extracted from the leaves of Marrubium vulgare L. against two fungal strains; Aspergillus niger ATCC 16404 and Candida albicans ATCC 10231...
  6. Guleryuz G, Erdemir U, Arslan H, Gucer S. Elemental composition of Marrubium astracanicum Jacq. growing in tungsten-contaminated sites. Environ Sci Pollut Res Int. 2016;23:18332-42 pubmed publisher
    This study evaluates the elemental (W, Mo, Zn, Fe, Cu, Cd, Mn, Pb, Cr, Co, B, and Bi) composition of Marrubium astracanicum Jacq...
  7. Yildirim A, Karakaş F, Turker A. In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey. Asian Pac J Trop Med. 2013;6:616-24 pubmed publisher
    ..reptans) L., Phlomis pungens (P. pungens) Willd., Marrubium astracanicum (M. astracanicum) Jacq., Nepeta nuda (N. nuda) L., Stachys annua (S. annua) L., Genista lydia (G...
  8. Rodríguez Villanueva J, Martín Esteban J. An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?. Phytother Res. 2016;30:1551-1558 pubmed publisher
    Aerial parts and the root of Marrubium vulgare L. (white horehound) have been traditionally used in Europe and in southern and eastern Mediterranean countries...
  9. Habibi G, Ajory N. The effect of drought on photosynthetic plasticity in Marrubium vulgare plants growing at low and high altitudes. J Plant Res. 2015;128:987-94 pubmed publisher
    ..We studied the photosynthetic plasticity of C3 plants at water deficit using ecotypes of Marrubium vulgare L. from high (2,200 m) and low (1,100 m) elevation sites in the Mishou-Dagh Mountains of Iran...
  10. Bouterfas K, Mehdadi Z, Elaoufi M, Latreche A, Benchiha W. Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linné) from three geographical origins. Ann Pharm Fr. 2016;74:453-462 pubmed publisher
    To elucidate the effect of the sampling location of Marrubium vulgare L. leaves on phenolic contents and antioxidant proprieties of flavonoids extracts. M. vulgare L...
  11. Barkaoui M, Katiri A, Boubaker H, Msanda F. Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco. J Ethnopharmacol. 2017;198:338-350 pubmed publisher
    ..The most frequently cited plant species are Allium sativum L., Salvia officinalis L., Marrubium vulgare L. and Lavandula dentata L...
  12. Paunovic V, Kosic M, Djordjevic S, Zugić A, Djalinac N, Gašić U, et al. Marrubium vulgare ethanolic extract induces proliferation block, apoptosis, and cytoprotective autophagy in cancer cells in vitro. Cell Mol Biol (Noisy-le-grand). 2016;62:108-114 pubmed
    b>Marrubium vulgare is a European medicinal plant with numerous beneficial effects on human health. The aim of the study was to isolate the plant ethanolic extract (MVE) and to investigate its anti-melanoma and anti-glioma effects...
  13. Garjani A, Tila D, Hamedeyazdan S, Vaez H, Rameshrad M, Pashaii M, et al. An investigation on cardioprotective potential of Marrubium vulgare aqueous fraction against ischaemia-reperfusion injury in isolated rat heart. Folia Morphol (Warsz). 2017;76:361-371 pubmed publisher
    The aim of this study was to evaluate the cardioprotective effects of aqueous fraction of Marrubium vulgare hydroalcoholic extract on cardiac parameters in ischaemic-reperfused isolated rat hearts...
  14. Malik R, Gupta R, Singh V, Bala S, Kumari S. New chromosome reports in Lamiaceae of Kashmir (Northwest Himalaya), India. Protoplasma. 2017;254:971-985 pubmed publisher
    ..Chromosome counts in the five species viz. Dracocephalum nutans (2n?=?10), Lycopus europaeus (2n?=?22), Marrubium vulgare (2n?=?54), Nepeta nervosa (2n?=?18) and Salvia sclarea (2n?=?22) are first time reported from India...
  15. Aouni R, Ben Attia M, Jaafoura M, Bibi Derbel A, Haouari M. Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats. Asian Pac J Trop Med. 2017;10:160-164 pubmed publisher
    To evaluate the effects of ethanol-water (80:20) extract of Marrubium vulgare (M. vulgare) on the hematological parameters, macroscopic and histological aspects of the uterus and fetus in non-pregnant and pregnant rats...
  16. Brahmi N, Scognamiglio M, Pacifico S, Mekhoukhe A, Madani K, Fiorentino A, et al. 1H NMR based metabolic profiling of eleven Algerian aromatic plants and evaluation of their antioxidant and cytotoxic properties. Food Res Int. 2015;76:334-341 pubmed publisher
    ..aromatic plants (Aloysia triphylla, Apium graveolens, Coriandrum sativum, Laurus nobilis, Lavandula officinalis, Marrubium vulgare, Mentha spicata, Inula viscosa, Petroselinum crispum, Salvia officinalis, and Thymus vulgaris) were ..
  17. Rodríguez Villanueva J, Martín Esteban J, Rodríguez Villanueva L. A Reassessment of the Marrubium Vulgare L. Herb's Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons. Medicines (Basel). 2017;4: pubmed publisher
    Despite the wide variety of pharmacological activities described for the Marrubium vulgare L. herb, amazingly, only one clinical trial can be found in scientific literature...
  18. Amri B, Martino E, Vitulo F, Corana F, Kaâb L, Rui M, et al. Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties. Molecules. 2017;22: pubmed publisher
    ..In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities...
  19. Meyre Silva C, Cechinel Filho V. A review of the chemical and pharmacological aspects of the genus marrubium. Curr Pharm Des. 2010;16:3503-18 pubmed
    The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil...
  20. Cigremis Y, Kart A, Karaman M, Erdag D. Attenuation of ischemia-reperfusion injury with Marrubium cordatum treatment in ovarian torsion-detorsion model in rabbits. Fertil Steril. 2010;93:1455-63 pubmed publisher
    To investigate protective effects of Marrubium cordatum extract on ovary torsion-detorsion.
  21. Alkhatib R, Joha S, Cheok M, Roumy V, Idziorek T, Preudhomme C, et al. Activity of ladanein on leukemia cell lines and its occurrence in Marrubium vulgare. Planta Med. 2010;76:86-7 pubmed publisher
    Three methoxylated flavones isolated from Marrubium peregrinum - ladanein, scutellarein-5,7,4'-trimethyl ether, and scutellarein-5,6,7,4'-tetramethyl ether - were assayed for their cytotoxicity towards a recently developed dasatinib-..
  22. El Bardai S, Wibo M, Hamaide M, Lyoussi B, Quetin Leclercq J, Morel N. Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. Br J Pharmacol. 2003;140:1211-6 pubmed
    ..study was to investigate the mechanism of the relaxant activity of marrubenol, a diterpenoid extracted from Marrubium vulgare. In rat aorta, marrubenol was a more potent inhibitor of the contraction evoked by 100 mM KCl (IC50: 11...
  23. El Bardai S, Lyoussi B, Wibo M, Morel N. Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat. Clin Exp Hypertens. 2004;26:465-74 pubmed
    Water extract of Marrubium vulgare is widely used as antihypertensive treatment in folk medicine...
  24. Argyropoulou A, Samara P, Tsitsilonis O, Skaltsa H. Polar constituents of Marrubium thessalum Boiss. & Heldr. (Lamiaceae) and their cytotoxic/cytostatic activity. Phytother Res. 2012;26:1800-6 pubmed publisher
    The methanol extract of the aerial parts of Marrubium thessalum Boiss. & Heldr. (Lamiaceae) afforded 30 phenolic metabolites, belonging to the classes of phenylethanoid glycosides, flavonoids and simple phenolic compounds...
  25. Argyropoulou C, Karioti A, Skaltsa H. Labdane diterpenes from Marrubium thessalum. Phytochemistry. 2009;70:635-40 pubmed publisher
    From the aerial parts of Marrubium thessalum, four labdane diterpenes, 13S-preperegrinine, 3alpha-hydroxymarrubiin, 9alpha,13R-15,16-bisepoxy-15beta-methoxy-3-oxo-labdan-6beta,19-olide and 15-methoxyvelutine C, have been isolated ..
  26. Argyropoulou C, Skaltsa H. Identification of essential oil components of Marrubium thessalum Boiss. & Heldr., growing wild in Greece. Nat Prod Res. 2012;26:593-9 pubmed publisher
    The essential oil of the Greek endemic species Marrubium thessalum Boiss. & Heldr. (Lamiaceae) was obtained by the hydrodistillation of its aerial parts during the flowering stage...
  27. Rigano D, Aviello G, Bruno M, Formisano C, Rosselli S, Capasso R, et al. Antispasmodic effects and structure-activity relationships of labdane diterpenoids from Marrubium globosum ssp. libanoticum. J Nat Prod. 2009;72:1477-81 pubmed publisher
    b>Marrubium globosum ssp. libanoticum is a medicinal plant used in Lebanon to reduce pain and smooth muscle spasms. A chloroform extract obtained from M...
  28. Laouer H, Yabrir B, Djeridane A, Yousfi M, Beldovini N, Lamamra M. Composition, antioxidant and antimicrobial activities of the essential oil of Marrubium deserti. Nat Prod Commun. 2009;4:1133-8 pubmed
    The essential oil from aerial part of Marrubium deserti De Noé (Lamiaceae), obtained by hydrodistillation was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), and evaluated for in vitro antimicrobial ..
  29. Hamedeyazdan S, Fathiazad F, Sharifi S, Nazemiyeh H. Antiproliferative activity of Marrubium persicum extract in the MCF-7 human breast cancer cell line. Asian Pac J Cancer Prev. 2012;13:5843-8 pubmed
    ..Developing antitumor drugs from natural products is receiving increasing interest worldwide due to limitations and side effects of therapy strategies for the second leading cause of disease related mortality, cancer...
  30. Carrasco Gil S, Siebner H, Leduc D, Webb S, Millán R, Andrews J, et al. Mercury localization and speciation in plants grown hydroponically or in a natural environment. Environ Sci Technol. 2013;47:3082-90 pubmed publisher
    ..conditions in a hydroponic system (30 ?M HgCl2) was compared with that of naturally occurring Horehound (Marrubium vulgare) plants collected from a mining soil polluted with Hg (Almadenejos, Spain) to characterize common ..
  31. Juárez Vázquez M, Carranza Alvarez C, Alonso Castro A, González Alcaraz V, Bravo Acevedo E, Chamarro Tinajero F, et al. Ethnobotany of medicinal plants used in Xalpatlahuac, Guerrero, México. J Ethnopharmacol. 2013;148:521-7 pubmed publisher
    ..Medicinal plants have been used for centuries for the empirical treatment of many diseases. This study documented the use of plant species in traditional medicine in the municipality of Xalpatlahuac, Guerrero, México...
  32. Yazici H, Kilic M, Solak M. Biosorption of copper(II) by Marrubium globosum subsp. globosum leaves powder: effect of chemical pretreatment. J Hazard Mater. 2008;151:669-75 pubmed
    The study was aimed at determining the effect of chemical pretreatment on copper(II) biosorption by Marrubium globosum subsp. globosum leaves...
  33. Yousefi K, Soraya H, Fathiazad F, Khorrami A, Hamedeyazdan S, Maleki Dizaji N, et al. Cardioprotective effect of methanolic extract of Marrubium vulgare L. on isoproterenol-induced acute myocardial infarction in rats. Indian J Exp Biol. 2013;51:653-60 pubmed
    ..The results demonstrate that M. vulgare protects myocardium against isoproterenol-induced acute myocardial infarction and suggest that the effects could be related to antioxidant activities...
  34. Petrovic S, Pavlović M, Maksimović Z, Milenkovic M, Couladis M, Tzakouc O, et al. Composition and antimicrobial activity of Marrubium incanum Desr. (Lamiaceae) essential oil. Nat Prod Commun. 2009;4:431-4 pubmed
    The essential oil from the aerial parts of Marrubium incanum Desr. (Lamiaceae), obtained by hydrodistillation, was analyzed by GC and GC-MS. Forty-six compounds were identified, representing 96.3% of the total oil...
  35. Karioti A, Skaltsa H, Heilmann J, Sticher O. Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum. Phytochemistry. 2003;64:655-60 pubmed
    From the aerial parts of Marrubium velutinum, one acylated flavonoid glycoside, chrysoeriol 7-O-(3",6"-di-O-E-p-coumaroyl)-beta-D-glucopyranoside, and two tetrasaccharidic phenylethanoid glycosides, velutinosides I-II, have ..
  36. Karioti A, Heilmann J, Skaltsa H. Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum. Phytochemistry. 2005;66:1060-6 pubmed
    From the aerial parts of Marrubium velutinum and Marrubium cylleneum, seven labdane diterpenes, velutine A, 15-epi-velutine A, velutine B, 15-epi-velutine B, velutine C, cyllenine A and 15-epi-cyllenine A, have been isolated together ..
  37. Rigano D, Grassia A, Bruno M, Rosselli S, Piozzi F, Formisano C, et al. Labdane Diterpenoids from Marrubium globosum ssp. libanoticum. J Nat Prod. 2006;69:836-8 pubmed
    From the aerial parts of Marrubium globosum ssp. libanoticum, seven labdane diterpenoids were isolated...
  38. Ettaya A, Dhibi S, Samout N, Elfeki A, Hfaiedh N. Hepatoprotective activity of white horehound (Marrubium vulgare) extract against cyclophosphamide toxicity in male rats. Can J Physiol Pharmacol. 2016;94:441-7 pubmed publisher
    The hepatoprotective activity of Marrubium vulgare against cyclophosphamide toxicity in Wistar rats was evaluated...
  39. Hayet E, Samia A, Patrick G, Ali M, Maha M, Laurent G, et al. Antimicrobial and cytotoxic activity of Marrubium alysson and Retama raetam grown in Tunisia. Pak J Biol Sci. 2007;10:1759-62 pubmed
    ..raetam showed the best activity against Gram positive organisms with MICs of 128 to 256 microg mL(-1) against methicillin resistant Staphylococcus aureus but low activity against the different Candida species...
  40. Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, et al. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology. 2012;143:213-22.e5 pubmed publisher
    ..We screened a library of plant-derived small molecules to identify HCV inhibitors with novel mechanisms...
  41. Karioti A, Skopeliti M, Tsitsilonis O, Heilmann J, Skaltsa H. Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Phytochemistry. 2007;68:1587-94 pubmed
    From the aerial parts of Marrubium cylleneum, one labdane nor-diterpene has been isolated together with two labdane diterpenes, hitherto not known as natural products...
  42. Paula de Oliveira A, Santin J, Lemos M, Klein Júnior L, Couto A, Meyre da Silva Bittencourt C, et al. Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae). J Pharm Pharmacol. 2011;63:1230-7 pubmed publisher
    ..The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare...
  43. Martin Nizard F, Sahpaz S, Kandoussi A, Carpentier M, Fruchart J, Duriez P, et al. Natural phenylpropanoids inhibit lipoprotein-induced endothelin-1 secretion by endothelial cells. J Pharm Pharmacol. 2004;56:1607-11 pubmed
    ..The tested compounds were phenylpropanoid glycosides previously isolated from the aerial parts of Marrubium vulgare L. (acteoside 1, forsythoside B 2, arenarioside 3 and ballotetroside 4)...
  44. Meyre Silva C, Yunes R, Schlemper V, Campos Buzzi F, Cechinel Filho V. Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae). Farmaco. 2005;60:321-6 pubmed
    Marrubiin, a furane labdane diterpene, is the main analgesic compound present in Marrubium vulgare, a medicinal plant used in Brazil and other countries to treat several ailments...
  45. Moreno Jiménez E, Gamarra R, Carpena Ruiz R, Millan R, Peñalosa J, Esteban E. Mercury bioaccumulation and phytotoxicity in two wild plant species of Almadén area. Chemosphere. 2006;63:1969-73 pubmed
    ..Our study focus on two of these plant species, Rumex induratus and Marrubium vulgare and their responses to natural Hg exposure...
  46. Rigano D, Grassia A, Borrelli F, Aviello G, Piozzi F, Bruno M, et al. Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum. Planta Med. 2006;72:575-8 pubmed
    ..globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition...
  47. Menéndez R, Thomas C. Can occupancy patterns be used to predict distributions in widely separated geographic regions?. Oecologia. 2006;149:396-405 pubmed
    ..Our results suggest that it maybe possible to make predictions from one landscape to another, even when the landscapes are widely separated...
  48. Ahmed B, Masoodi M, Siddique A, Khan S. A new monoterpene acid from Marrubium vulgare with potential antihepatotoxic activity. Nat Prod Res. 2010;24:1671-80 pubmed publisher
    The whole plant of Marrubium vulgare L. afforded a new terpenoid, characterised as p-menthane-5,6-dihydroxy-3-carboxylic acid (1), which has been designated as marrubic acid...
  49. Boudjelal A, Henchiri C, Siracusa L, Sari M, Ruberto G. Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion. Fitoterapia. 2012;83:286-92 pubmed publisher
    b>Marrubium vulgare (Lamiaceae) is a plant traditionally used for the treatment of diabetes in Algeria. Compositional analysis of the aqueous infusion revealed the presence of fifteen metabolites, all belonging to the class of polyphenols...
  50. Argyropoulou C, Karioti A, Skaltsa H. Minor labdane diterpenes from Marrubium thessalum. Chem Biodivers. 2011;8:1880-90 pubmed publisher
    ..were isolated from the aerial parts of Marrubium thessalum, along with the known labdane diterpene deacetylvitexilactone (6) and the methoxylated flavones 4',7-..
  51. Zarai Z, Kadri A, Ben Chobba I, Ben Mansour R, Bekir A, Mejdoub H, et al. The in-vitro evaluation of antibacterial, antifungal and cytotoxic properties of Marrubium vulgare L. essential oil grown in Tunisia. Lipids Health Dis. 2011;10:161 pubmed publisher
    ..vulgare L. essential oil against different pathogenic microorganisms and the cytotoxic activity against HeLa cell lines...
  52. Martin Nizard F, Sahpaz S, Furman C, Fruchart J, Duriez P, Bailleul F. Natural phenylpropanoids protect endothelial cells against oxidized LDL-induced cytotoxicity. Planta Med. 2003;69:207-11 pubmed
    ..of this study was to test the protective effect of five natural polyphenols isolated from the aerial parts of Marrubium vulgare L. against mOx-LDL-induced cytotoxicity in BAEC...
  53. El Bardai S, Morel N, Wibo M, Fabre N, Llabres G, Lyoussi B, et al. The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare. Planta Med. 2003;69:75-7 pubmed
    Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta...
  54. Ohtera A, Miyamae Y, Nakai N, Kawachi A, Kawada K, Han J, et al. Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor ? agonist. Biochem Biophys Res Commun. 2013;440:204-9 pubmed publisher
    6-Octadecynoic acid (6-ODA), a fatty acid with a triple bond, was identified in the methanol extract of Marrubium vulgare L. as an agonist of peroxisome proliferator-activated receptor ? (PPAR?)...